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22 results on '"Glick-Saar, Efrat"'

7. Small Extracellular Vesicles from Failing Heart Accelerate Tumor Growth

Author

Caller, Tal, primary, Rotem, Itai, additional, Shaihov Teper, Olga, additional, Lendengolts, Daria, additional, Schary, Yeshai, additional, Shai, Ruty, additional, Glick Saar, Efrat, additional, Dominissini, Dan, additional, Motie, Menachem, additional, Katzir, Idan, additional, Popovtzer, Rachela, additional, Nahmoud, Merav, additional, Boomgarden, Alex, additional, DSouza Schorey, Crislyn, additional, Naftali Shani, Nili, additional, and Leor, Jonathan, additional

Published
2023
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8. Abstract P3155: Cardiac Extracellular Vesicles Mediate The Neoplastic Properties Of Heart Failure

Author

Caller, Tal, primary, Rotem, Itai, additional, Shaihov–Teper, Olga, additional, Lendengolts, Daria, additional, Schary, Yeshai, additional, Shai, Ruty, additional, Glick-Saar, Efrat, additional, Dominissini, Dan, additional, Boomgarden, Alex, additional, D’Souza-Schorey, Crislyn, additional, Naftali Shani, Nili, additional, and Leor, Jonathan, additional

Published
2023
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10. Proteomic signature for detection of high‐grade ovarian cancer in germline BRCA mutation carriers

Author

Bahar‐Shany, Keren, primary, Barnabas, Georgina D., additional, Deutsch, Lisa, additional, Deutsch, Netanel, additional, Glick‐Saar, Efrat, additional, Dominissini, Dan, additional, Sapoznik, Stav, additional, Helpman, Limor, additional, Perri, Tamar, additional, Blecher, Anna, additional, Katz, Guy, additional, Yagel, Itai, additional, Rosenblatt, Orgad, additional, Shai, Daniel, additional, Brandt, Benny, additional, Meyer, Raanan, additional, Mohr‐Sasson, Aya, additional, Volodarsky‐Perel, Alexander, additional, Zilberman, Itamar, additional, Armon, Shunit, additional, Jakobson‐Setton, Ariella, additional, Eitan, Ram, additional, Kadan, Yfat, additional, Beiner, Mario, additional, Josephy, Dana, additional, Brodsky, Malka, additional, Friedman, Eitan, additional, Anafi, Liat, additional, Molchanov, Yossef, additional, Korach, Jacob, additional, Geiger, Tamar, additional, and Levanon, Keren, additional

Published
2022
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11. Abstract P3104: Extracellular Vesicles From The Infarcted Heart Facilitate Tumor Growth

Author

Caller, Tal, primary, Shaihov–Teper, Olga, additional, Schary, Yeshai, additional, Lendengolts, Daria, additional, Rotem, Itai, additional, Peled, Racheli, additional, Shai, Ruty, additional, Amit, Uri, additional, Glick-Saar, Efrat, additional, Dominissini, Dan, additional, Boomgarden, Alex, additional, D'Souza-Schorey, Crislyn, additional, Naftali-Shani, Nili, additional, and Leor, Jonathan, additional

Published
2022
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12. Deleterious variants in TRAK1 disrupt mitochondrial movement and cause fatal encephalopathy

Author

Barel, Ortal, Christine V. Malicdan, May, Ben-Zeev, Bruria, Kandel, Judith, Pri-Chen, Hadass, Stephen, Joshi, Castro, Inês G., Metz, Jeremy, Atawa, Osama, Moshkovitz, Sharon, Ganelin, Eti, Barshack, Iris, Polak-Charcon, Sylvie, Nass, Dvora, Marek-Yagel, Dina, Amariglio, Ninette, Shalva, Nechama, Vilboux, Thierry, Ferreira, Carlos, Pode-Shakked, Ben, Heimer, Gali, Hoffmann, Chen, Yardeni, Tal, Nissenkorn, Andreea, Avivi, Camila, Eyal, Eran, Kol, Nitzan, Glick Saar, Efrat, Wallace, Douglas C., Gahl, William A., Rechavi, Gideon, Schrader, Michael, Eckmann, David M., and Anikster, Yair

Published
2017
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13. Proteomic signature for detection of high‐grade ovarian cancer in germline BRCA mutation carriers.

Author

Bahar‐Shany, Keren, Barnabas, Georgina D., Deutsch, Lisa, Deutsch, Netanel, Glick‐Saar, Efrat, Dominissini, Dan, Sapoznik, Stav, Helpman, Limor, Perri, Tamar, Blecher, Anna, Katz, Guy, Yagel, Itai, Rosenblatt, Orgad, Shai, Daniel, Brandt, Benny, Meyer, Raanan, Mohr‐Sasson, Aya, Volodarsky‐Perel, Alexander, Zilberman, Itamar, and Armon, Shunit

Subjects
BRCA genes, PROTEOMICS, GERM cells, SAMPLING (Process), GENETIC mutation, OVARIAN cancer
Abstract

No current screening methods for high‐grade ovarian cancer (HGOC) guarantee effective early detection for high‐risk women such as germline BRCA mutation carriers. Therefore, the standard‐of‐care remains risk‐reducing salpingo‐oophorectomy (RRSO) around age 40. Proximal liquid biopsy is a promising source of biomarkers, but sensitivity has not yet qualified for clinical implementation. We aimed to develop a proteomic assay based on proximal liquid biopsy, as a decision support tool for monitoring high‐risk population. Ninety Israeli BRCA1 or BRCA2 mutation carriers were included in the training set (17 HGOC patients and 73 asymptomatic women), (BEDOCA trial; ClinicalTrials.gov Identifier: NCT03150121). The proteome of the microvesicle fraction of the samples was profiled by mass spectrometry and a classifier was developed using logistic regression. An independent cohort of 98 BRCA mutation carriers was used for validation. Safety information was collected for all women who opted for uterine lavage in a clinic setting. We present a 7‐protein diagnostic signature, with AUC >0.97 and a negative predictive value (NPV) of 100% for detecting HGOC. The AUC of the biomarker in the independent validation set was >0.94 and the NPV >99%. The sampling procedure was clinically acceptable, with favorable pain scores and safety. We conclude that the acquisition of Müllerian tract proximal liquid biopsies in women at high‐risk for HGOC and the application of the BRCA‐specific diagnostic assay demonstrates high sensitivity, specificity, technical feasibility and safety. Similar classifier for an average‐risk population is warranted. [ABSTRACT FROM AUTHOR]

Published
2023
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14. Reduced Function and Diversity of T Cell Repertoire and Distinct Clinical Course in Patients With IL7RA Mutation

Author

Lev, Atar, primary, Simon, Amos J., additional, Barel, Ortal, additional, Eyal, Eran, additional, Glick-Saar, Efrat, additional, Nayshool, Omri, additional, Birk, Ohad, additional, Stauber, Tali, additional, Hochberg, Amit, additional, Broides, Arnon, additional, Almashanu, Shlomo, additional, Hendel, Ayal, additional, Lee, Yu Nee, additional, and Somech, Raz, additional

Published
2019
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15. Pseudouridines on Trypanosoma brucei spliceosomal small nuclear RNAs and their implication for RNA and protein interactions

Author

Rajan, K Shanmugha, primary, Doniger, Tirza, additional, Cohen-Chalamish, Smadar, additional, Chen, Dana, additional, Semo, Oz, additional, Aryal, Saurav, additional, Glick Saar, Efrat, additional, Chikne, Vaibhav, additional, Gerber, Doron, additional, Unger, Ron, additional, Tschudi, Christian, additional, and Michaeli, Shulamit, additional

Published
2019
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16. Individualized Dynamics in the Gut Microbiota Precede Crohn's Disease Flares

Author

Braun, Tzipi, primary, Di Segni, Ayelet, additional, BenShoshan, Marina, additional, Neuman, Sandra, additional, Levhar, Nina, additional, Bubis, Michael, additional, Picard, Orit, additional, Sosnovski, Katya, additional, Efroni, Gilat, additional, Farage Barhom, Sarit, additional, Glick Saar, Efrat, additional, Lahad, Avishay, additional, Weiss, Batia, additional, Yablecovitch, Doron, additional, Lahat, Adi, additional, Eliakim, Rami, additional, Kopylov, Uri, additional, Ben-Horin, Shomron, additional, and Haberman, Yael, additional

Published
2019
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18. RNA editing by ADAR1 leads to context-dependent transcriptome-wide changes in RNA secondary structure

Author

Solomon, Oz, primary, Di Segni, Ayelet, additional, Cesarkas, Karen, additional, Porath, Hagit T., additional, Marcu-Malina, Victoria, additional, Mizrahi, Orel, additional, Stern-Ginossar, Noam, additional, Kol, Nitzan, additional, Farage-Barhom, Sarit, additional, Glick-Saar, Efrat, additional, Lerenthal, Yaniv, additional, Levanon, Erez Y., additional, Amariglio, Ninette, additional, Unger, Ron, additional, Goldstein, Itamar, additional, Eyal, Eran, additional, and Rechavi, Gidi, additional

Published
2017
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19. Fecal microbial characterization of hospitalized patients with suspected infectious diarrhea shows significant dysbiosis

Author

Braun, Tzipi, primary, Di Segni, Ayelet, additional, BenShoshan, Marina, additional, Asaf, Roy, additional, Squires, James E., additional, Farage Barhom, Sarit, additional, Glick Saar, Efrat, additional, Cesarkas, Karen, additional, Smollan, Gill, additional, Weiss, Batia, additional, Amit, Sharon, additional, Keller, Nathan, additional, and Haberman, Yael, additional

Published
2017
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20. Abstract A34: Activation-induced cytidine deaminase links ovulation-induced inflammation and serous carcinogenesis.

Author

Sapoznik, Stav, primary, Bahar-Shany, Keren, additional, Brand, Hadar, additional, Pinto, Yishay, additional, Gabay, Orshay, additional, Glick-Saar, Efrat, additional, Dor, Chen, additional, Zadok, Oranit, additional, Barshack, Iris, additional, Zundelevich, Adi, additional, Gal-Yam, Einav Nili, additional, Yung, Yuval, additional, Hourvitz, Ariel, additional, Korach, Jacob, additional, Beiner, Mario, additional, Jacob, Jasmine, additional, Levanon, Erez Y., additional, Barak, Michal, additional, Aviel-Ronen, Sarit, additional, and Levanon, Keren, additional

Published
2016
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21. RNA editing by ADAR1 leads to context-dependent transcriptome-wide changes in RNA secondary structure.

Author

Di Segni, Ayelet, Cesarkas, Karen, Marcu-Malina, Victoria, Kol, Nitzan, Farage-Barhom, Sarit, Glick-Saar, Efrat, Lerenthal, Yaniv, Eyal, Eran, Solomon, Oz, Amariglio, Ninette, Goldstein, Itamar, Rechavi, Gidi, Porath, Hagit T., Levanon, Erez Y., Unger, Ron, Mizrahi, Orel, and Stern-Ginossar, Noam

Subjects
RNA editing, RNA analysis, ADENOSINE deaminase, INTERFERONS, RNA sequencing
Abstract

Adenosine deaminase acting on RNA 1 (ADAR1) is the master RNA editor, catalyzing the deamination of adenosine to inosine. RNA editing is vital for preventing abnormal activation of cytosolic nucleic acid sensing pathways by self-double-stranded RNAs. Here we determine, by parallel analysis of RNA secondary structure sequencing (PARS-seq), the global RNA secondary structure changes in ADAR1 deficient cells. Surprisingly, ADAR1 silencing resulted in a lower global double-stranded to single-stranded RNA ratio, suggesting that A-to-I editing can stabilize a large subset of imperfect RNA duplexes. The duplexes destabilized by editing are composed of vastly complementary inverted Alus found in untranslated regions of genes performing vital biological processes, including housekeeping functions and type-I interferon responses. They are predominantly cytoplasmic and generally demonstrate higher ribosomal occupancy. Our findings imply that the editing effect on RNA secondary structure is context dependent and underline the intricate regulatory role of ADAR1 on global RNA secondary structure. [ABSTRACT FROM AUTHOR]

Published
2017
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22. GATA6-AS1 Regulates Intestinal Epithelial Mitochondrial Functions, and its Reduced Expression is Linked to Intestinal Inflammation and Less Favourable Disease Course in Ulcerative Colitis.

Author

Sosnovski KE, Braun T, Amir A, Moshel D, BenShoshan M, VanDussen KL, Levhar N, Abbas-Egbariya H, Beider K, Ben-Yishay R, Asad Ali S, Moore SR, Kugathasan S, Abramovich I, Glick Saar E, Weiss B, Barshack I, Gottlieb E, Geiger T, Ben-Horin S, Ulitsky I, Hyams JS, Denson LA, and Haberman Y

Subjects
Humans, Caco-2 Cells, Intestinal Mucosa metabolism, Rectum, Inflammation metabolism, Mitochondria metabolism, GATA6 Transcription Factor metabolism, Colitis, Ulcerative genetics, Colitis, Ulcerative metabolism, Celiac Disease, Crohn Disease metabolism
Abstract

Background and Aims: Widespread dysregulation of long non-coding RNAs [lncRNAs] including a reduction in GATA6-AS1 was noted in inflammatory bowel disease [IBD]. We previously reported a prominent inhibition of epithelial mitochondrial functions in ulcerative colitis [UC]. However, the connection between reduction of GATA6-AS1 expression and attenuated epithelial mitochondrial functions was not defined., Methods: Mucosal transcriptomics was used to conform GATA6-AS1 reduction in several treatment-naïve independent human cohorts [n=673]. RNA pull-down followed by mass spectrometry was used to determine the GATA6-AS1 interactome. Metabolomics and mitochondrial respiration following GATA6-AS1 silencing in Caco-2 cells were used to elaborate on GATA6-AS1 functions., Results: GATA6-AS1 showed predominant expression in gut epithelia using single cell datasets. GATA6-AS1 levels were reduced in Crohn's disease [CD] ileum and UC rectum in independent cohorts. Reduced GATA6-AS1 lncRNA was further linked to a more severe UC form, and to a less favourable UC course. The GATA6-AS1 interactome showed robust enrichment for mitochondrial proteins, and included TGM2, an autoantigen in coeliac disease that is induced in UC, CD and coeliac disease, in contrast to GATA6-AS1 reduction in these cohorts. GATA6-AS1 silencing resulted in induction of TGM2, and this was coupled with a reduction in mitochondrial membrane potential and mitochondrial respiration, as well as in a reduction of metabolites linked to aerobic respiration relevant to mucosal inflammation. TGM2 knockdown in GATA6-AS1-deficient cells rescued mitochondrial respiration., Conclusions: GATA6-AS1 levels are reduced in UC, CD and coeliac disease, and in more severe UC forms. We highlight GATA6-AS1 as a target regulating epithelial mitochondrial functions, potentially through controlling TGM2 levels., (© The Author(s) 2023. Published by Oxford University Press on behalf of European Crohn’s and Colitis Organisation.)

Published
2023
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