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4. Decoding the historical tale: COVID-19 impact on haematological malignancy patients—EPICOVIDEHA insights from 2020 to 2022

Author

Martín-Vallejo, Francisco Javier, Zdziarski, Przemyslaw, Zarrinfer, Hossein, Wittig, Jana, Win, Sein, Wai-Man, Vivien, Víšek, Benjamín, Vinh, Donald C., Vehreschild, Maria, Varricchio, Gina, Tsirigotis, Panagiotis, Torres-Tienza, Ana, Tanase, Alina Daniela, Tafuri, Agostino, Stamouli, Maria, Sramek, Jiří, Soussain, Carole, Shirinova, Ayten, Schubert, Jörg, Schalk, Enrico, Salehi, Mohammad Reza, Saleh, Modar, Rosati, Giorgio, Roldán, Elisa, Reizine, Florian, Rêgo, Mayara, Regalado-Artamendi, Isabel, Popova, Marina, Pinto, Fernando, Philippe, Laure, Orth, Hans Martin, Ommen, Hans-Beier, Obr, Aleš, Núñez-Martín-Buitrago, Lucía, Noël, Nicolas, Neuhann, Julia, Nadali, Gianpaolo, Nacov, Julia A., Munhoz Alburquerque, Ana M., Mitra, Maria Enza, Mikulska, Malgorzata, Mellinghoff, Sibylle, Mechtel, Ben, Martín-González, Juan-Alberto, Malak, Sandra, Loureiro-Amigo, Jorge, Lorenzo De La Peña, Lisset, Liberti, Giulia, Landau, Marianne, Lacej, Ira, Kolditz, Martin, Kho, Chi Shan, Khedr, Reham Abdelaziz, Karthaus, Meinolf, Karlsson, Linda Katharina, Jiménez-Lorenzo, María-Josefa, Izuzquiza, Macarena, Hoell-Neugebauer, Baerbel, Herbrecht, Raoul, Heath, Christopher H., Guolo, Fabio, Grothe, Jan, Giordano, Antonio, Gerasymchuk, Sergey, García-Sanz, Ramón, García-Poutón, Nicole, Funke, Vaneuza Araújo Moreira, Fung, Monica, Flasshove, Charlotte, Fianchi, Luana, Essame, Jenna, Egger, Matthias, Drenou, Bernard, Dragonetti, Giulia, Desole, Maximilian, Della Pepa, Roberta, Deau Fischer, Bénédicte, De Kort, Elizabeth, De Cabo, Erik, Danion, François, Daguindau, Etienne, Cushion, Tania, Cremer, Louise, Criscuolo, Marianna, Cordini, Gregorio, Cingolani, Antonella, Ciceri, Fabio, Chowdhury, Fazle Rabbi, Chelysheva, Ekaterina, Chauchet, Adrien, Chai, Louis Yi Ann, Ceesay, M. Mansour, Busch, Elena, Brehon, Mathias, Borducchi, Davimar M.M., Booth, Stephen, Bologna, Serge, Berg Venemyr, Caroline, Bailén-Almorox, Rebeca, Antoniadou, Anastasia, Anastasopoulou, Amalia N., Altuntaş, Fevzi, Salmanton-García, Jon, Marchesi, Francesco, Farina, Francesca, Weinbergerová, Barbora, Itri, Federico, Dávila-Valls, Julio, Martín-Pérez, Sonia, Glenthøj, Andreas, Hersby, Ditte Stampe, Gomes Da Silva, Maria, Nunes Rodrigues, Raquel, López-García, Alberto, Córdoba, Raúl, Bilgin, Yavuz M., Falces-Romero, Iker, El-Ashwah, Shaimaa, Emarah, Ziad, Besson, Caroline, Kohn, Milena, Van Doesum, Jaap, Ammatuna, Emanuele, Marchetti, Monia, Labrador, Jorge, Zambrotta, Giovanni Paolo Maria, Verga, Luisa, Jaksic, Ozren, Nucci, Marcio, Piukovics, Klára, Cabirta-Touzón, Alba, Jiménez, Moraima, Arellano, Elena, Espigado, Ildefonso, Blennow, Ola, Nordlander, Anna, Meers, Stef, Vian Praet, Jens, Aiello, Tommaso Francesco, Garcia-Vidal, Carolina, Fracchiolla, Nicola S., Sciumè, Mariarita, Seval, Guldane Cengiz, Žák, Pavel, Buquicchio, Caterina, Tascini, Carlo, Gräfe, Stefanie K., Schönlein, Martin, Adžić-VUKIČEVIĆ, Tatjana, Bonuomo, Valentina, Cattaneo, Chiara, Nizamuddin, Summiya, Čerňan, Martin, Plantefeve, Gaëtan, Prin, Romane, Szotkovski, Tomas, Collins, Graham P., Dargenio, Michelina, Petzer, Verena, Wolf, Dominik, Čolović, Natasha, Prezioso, Lucia, Valković, Toni, Passamonti, Francesco, Méndez, Gustavo-Adolfo, Sili, Uluhan, Vena, Antonio, Bavastro, Martina, Limongelli, Alessandro, Duarte, Rafael F., Ledoux, Marie-Pierre, Cvetanoski, Milche, Stojanoski, Zlate, Machado, Marina, Batinić, Josip, Magliano, Gabriele, Biernat, Monika M., Pantić, Nikola, Poulsen, Christian Bjørn, Cuccaro, Annarosa, Del Principe, Maria Ilaria, Kulasekararaj, Austin, Ormazabal-Vélez, Irati, Busca, Alessandro, Demirkan, Fatih, Ijaz, Marriyam, Klimko, Nikolai, Stoma, Igor, Khostelidi, Sofya, Fernández, Noemí, Omrani, Ali S., Bergantim, Rui, De Jonge, Nick, Fouquet, Guillemette, Navrátil, Milan, Abu-Zeinah, Ghaith, Samarkos, Michail, Maertens, Johan, De Ramón, Cristina, Guidetti, Anna, Magyari, Ferenc, González-López, Tomás José, Lahmer, Tobias, Finizio, Olimpia, Ali, Natasha, Pinczés, László Imre, Lavilla-Rubira, Esperanza, Romano, Alessandra, Merelli, Maria, Delia, Mario, Calbacho, Maria, Meletiadis, Joseph, Antić, Darko, Hernández-Rivas, José-Ángel, Marques De Almeida, Joyce, Al-Khabori, Murtadha, Hoenigl, Martin, Tisi, Maria Chiara, Khanna, Nina, Barać, Aleksandra, Eisa, Noha, Di Blasi, Roberta, Liévin, Raphaël, Miranda-Castillo, Carolina, Bahr, Nathan C., Lamure, Sylvain, Papa, Mario Virgilio, Yahya, Ayel, Aujayeb, Avinash, Novák, Jan, Erben, Nurettin, Fernández-Galán, María, Ribera-Santa Susana, José-María, Rinaldi, Ikhwan, Fazzi, Rita, Piedimonte, Monica, Duléry, Rémy, Gonzaga, Yung, Soto-Silva, Andrés, Sapienza, Giuseppe, Serris, Alexandra, Drgoňa, Ľuboš, Groh, Ana, Serrano, Laura, Gavriilaki, Eleni, Tragiannidis, Athanasios, Prattes, Juergen, Coppola, Nicola, Otašević, Vladimir, Mladenović, Miloš, Mitrović, Mirjana, Mišković, Bojana, Jindra, Pavel, Zompi, Sofia, Sacchi, Maria Vittoria, Krekeler, Carolin, Shumilov, Evgenii, Infante, Maria Stefania, García-Bordallo, Daniel, Çolak, Gökçe Melis, Mayer, Jiří, Nygaard, Marietta, Hanáková, Michaela, Ráčil, Zdeněk, Quattrone, Martina, Bonanni, Matteo, Koehler, Philipp, Rahimli, Laman, Cornely, Oliver A., and Pagano, Livio

Published
2024
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5. Diagnosis and management of pyruvate kinase deficiency: international expert guidelines

Author

Al-Samkari, Hanny, Shehata, Nadine, Lang-Robertson, Kelly, Bianchi, Paola, Glenthøj, Andreas, Sheth, Sujit, Neufeld, Ellis J, Rees, David C, Chonat, Satheesh, Kuo, Kevin H M, Rothman, Jennifer A, Barcellini, Wilma, van Beers, Eduard J, Pospíšilová, Dagmar, Shah, Ami J, van Wijk, Richard, Glader, Bertil, Mañú Pereira, Maria Del Mar, Andres, Oliver, Kalfa, Theodosia A, Eber, Stefan W, Gallagher, Patrick G, Kwiatkowski, Janet L, Galacteros, Frédéric, Lander, Carl, Watson, Alejandra, Elbard, Riyad, Peereboom, Dore, and Grace, Rachael F

Published
2024
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7. Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients: EPICOVIDEHA findings

Author

MARQUES DE ALMEIDA, Joyce, HERNÁNDEZ-RIVAS, José-Ángel, GUIDETTI, Anna, FINIZIO, Olimpia, STOJANOSKI, Zlate, CVETANOSKI, Milche, MELETIADIS, Joseph, DE JONGE, Nick, ANTIĆ, Darko, ALI, Natasha, TISI, Maria Chiara, SERRANO, Laura, PLANTEFEVE, Gaëtan, KHANNA, Nina, HOENIGL, Martin, ČERŇAN, Martin, MIRANDA-CASTILLO, Carolina, FERNÁNDEZ-GALÁN, María, SERRIS, Alexandra, ERBEN, Nurettin, DULÉRY, Rémy, AUJAYEB, Avinash, PAPA, Mario Virgilio, NOVÁK, Jan, DELIA, Mario, SAPIENZA, Giuseppe, REIZINE, Florian, OMRANI, Ali S., DI BLASI, Roberta, LAMURE, Sylvain, DRGOŇA, Ľuboš, COPPOLA, Nicola, BATINIĆ, Josip, AL-KHABORI, Murtadha, RIBERA-SANTA SUSANA, José-María, PIEDIMONTE, Monica, LOUREIRO-AMIGO, Jorge, FOUQUET, Guillemette, FAZZI, Rita, DANION, François, SCHUBERT, Jörg, HOELL-NEUGEBAUER, Baerbel, BAHR, Nathan C., YAHIA, Ayel Omar, TORRES-ATIENZA, Ana, RINALDI, Ikhwan, POPOVA, Marina, OMMEN, Hans-Beier, MITRA, Maria Enza, MIKULSKA, Malgorzata, LACEJ, Ira, KHOSTELIDI, Sofya, WIN, Sein, VINH, Donald, SALEH, Modar, PRATTES, Juergen, JINDRA, Pavel, GUOLO, Fabio, DELLA PEPA, Roberta, CHELYSHEVA, Ekaterina, ZDZIARSKI, Przemyslaw, WAI-MAN, Vivien, SOTO-SILVA, Andrés, ORTH, Hans Martin, MALAK, Sandra, LORENZO DE LA PEÑA, Lisset, KOLDITZ, Martin, Shan KHO, Chi, HEATH, Christopher H., GROH, Ana, GAVRIILAKI, Eleni, FUNG, Monica, EGGER, Matthias, DE KORT, Elizabeth, DE CABO, Erik, CUSHION, Tania, CHOWDHURY, Fazle Rabbi, CEESAY, M. Mansour, BREHON, Mathias, VARRICCHIO, Gina, TAFURI, Agostino, JIMÉNEZ-LORENZO, María-Josefa, KLIMKO, Nikolai, TSIRIGOTIS, Panagiotis, ANTONIADOU, Anastasia, VEHRESCHILD, Maria, Rossi, Giuseppe, Salmanton-García, Jon, Cattaneo, Chiara, Marchesi, Francesco, Dávila-Valls, Julio, Martín-Pérez, Sonia, Itri, Federico, López-García, Alberto, Glenthøj, Andreas, Gomes da Silva, Maria, Besson, Caroline, Marchetti, Monia, Weinbergerová, Barbora, Jaksic, Ozren, Jiménez, Moraima, Bilgin, Yavuz M., Van Doesum, Jaap, Farina, Francesca, Žák, Pavel, Verga, Luisa, Collins, Graham P., Bonuomo, Valentina, Van Praet, Jens, Nucci, Marcio, Meers, Stef, Espigado, Ildefonso, Fracchiolla, Nicola S., Valković, Toni, Poulsen, Christian Bjørn, Čolović, Natasha, Dragonetti, Giulia, Ledoux, Marie-Pierre, Tascini, Carlo, Buquicchio, Caterina, Blennow, Ola, Passamonti, Francesco, Machado, Marina, Labrador, Jorge, Duarte, Rafael F., Schönlein, Martin, Prezioso, Lucia, Falces-Romero, Iker, Kulasekararaj, Austin, Garcia-Vidal, Carolina, Fernández, Noemí, Abu-Zeinah, Ghaith, Ormazabal-Vélez, Irati, Adžić-Vukičević, Tatjana, Piukovics, Klára, Stoma, Igor, Cuccaro, Annarosa, Magliano, Gabriele, Szotkowski, Tomáš, González-López, Tomás-José, El-Ashwah, Shaimaa, Bergantim, Rui, Sili, Uluhan, Maertens, Johan, Demirkan, Fatih, De Ramón, Cristina, Petzer, Verena, Del Principe, Maria Ilaria, Navrátil, Milan, Dargenio, Michelina, Seval, Guldane Cengiz, Samarkos, Michail, Ráčil, Zdeněk, Pinczés, László Imre, Lahmer, Tobias, Busca, Alessandro, Méndez, Gustavo-Adolfo, Vena, Antonio, Biernat, Monika M., Merelli, Maria, Calbacho, Maria, Barać, Aleksandra, Bavastro, Martina, Limongelli, Alessandro, Ilhan, Osman, Wolf, Dominik, Çolak, Gökçe Melis, García-Sanz, Ramón, Emarah, Ziad, Mišković, Bojana, Gräfe, Stefanie K., Mladenović, Miloš, Aiello, Tommaso Francesco, Núñez-Martín-Buitrago, Lucía, Nordlander, Anna, Arellano, Elena, Zambrotta, Giovanni Paolo Maria, Ammatuna, Emanuele, Cabirta, Alba, Sacchi, Maria Vittoria, Nunes Rodrigues, Raquel, Hersby, Ditte Stampe, Hanakova, Michaela, Rahimli, Laman, Cordoba, Raul, Cornely, Oliver A., and Pagano, Livio

Published
2023
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8. Molnupiravir compared to nirmatrelvir/ritonavir for COVID-19 in high-risk patients with haematological malignancy in Europe. A matched-paired analysis from the EPICOVIDEHA registry

Author

Salmanton-García, Jon, Marchesi, Francesco, Koehler, Philipp, Weinbergerová, Barbora, Čolović, Natasa, Falces-Romero, Iker, Buquicchio, Caterina, Farina, Francesca, van Praet, Jens, Biernat, Monika M., Itri, Federico, Prezioso, Lucia, Tascini, Carlo, Vena, Antonio, Romano, Alessandra, Delia, Mario, Dávila-Valls, Julio, Martín-Pérez, Sonia, Lavilla-Rubira, Esperanza, Adžić-vukičević, Tatjana, García-Bordallo, Daniel, López-García, Alberto, Criscuolo, Mariana, Petzer, Verena, Fracchiolla, Nicola S., Espigado, Ildefonso, Sili, Uluhan, Meers, Stef, Erben, Nurettin, Cattaneo, Chiara, Tragiannidis, Athanasios, Gavriilaki, Eleni, Schönlein, Martin, Mitrovic, Mirjana, Pantic, Nikola, Merelli, Maria, Labrador, Jorge, Hernández-Rivas, José-Ángel, Glenthøj, Andreas, Fouquet, Guillemette, del Principe, Maria Ilaria, Dargenio, Michelina, Calbacho, María, Besson, Caroline, Kohn, Milena, Gräfe, Stefanie, Hersby, Ditte Stampe, Arellano, Elena, Çolak, Gökçe Melis, Wolf, Dominik, Marchetti, Monia, Nordlander, Anna, Blennow, Ola, Cordoba, Raul, Mišković, Bojana, Mladenović, Miloš, Bavastro, Martina, Limongelli, Alessandro, Rahimli, Laman, Pagano, Livio, and Cornely, Oliver A.

Published
2023
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10. Sickle cell disease landscape and challenges in the EU: the ERN-EuroBloodNet perspective

Author

Mañú Pereira, María del Mar, Colombatti, Raffaella, Alvarez, Federico, Bartolucci, Pablo, Bento, Celeste, Brunetta, Angelo Loris, Cela, Elena, Christou, Soteroula, Collado, Anna, de Montalembert, Mariane, Dedeken, Laurence, Fenaux, Pierre, Galacteros, Frédéric, Glenthøj, Andreas, Gutiérrez Valle, Victoria, Kattamis, Antonis, Kunz, Joachim, Lobitz, Stephan, McMahon, Corrina, Pellegrini, Mariangela, Reidel, Sara, Russo, Giovanna, Santos Freire, Miriam, van Beers, Eduard, Kountouris, Petros, and Gulbis, Béatrice

Published
2023
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11. Nirmatrelvir/ritonavir in COVID-19 patients with haematological malignancies: a report from the EPICOVIDEHA registry

Author

Piukovics, Klára, De Ramón, Cristina, Danion, François, Yahya, Ayel, Guidetti, Anna, Garcia-Vidal, Carolina, Sili, Uluhan, Meletiadis, Joseph, De Kort, Elizabeth, Verga, Luisa, Serrano, Laura, Erben, Nurettin, Di Blasi, Roberta, Tragiannidis, Athanasios, Ribera-Santa Susana, José-María, Ommen, Hans-Beier, Busca, Alessandro, Coppola, Nicola, Bergantim, Rui, Dragonetti, Giulia, Criscuolo, Marianna, Fianchi, Luana, Bonanni, Matteo, Soto-Silva, Andrés, Mikulska, Malgorzata, Machado, Marina, Shan Kho, Chi, Hassan, Nazia, Gavriilaki, Eleni, Cordini, Gregorio, Chi, Louis Yi Ann, Eggerer, Matthias, Hoenigl, Martin, Prattes, Juergen, Jiménez-Lorenzo, María-Josefa, Zompi, Sofia, Zambrotta, Giovanni Paolo Maria, Çolak, Gökçe Melis, García-Poutón, Nicole, Aiello, Tommaso Francesco, Prin, Romane, Stamouli, Maria, Samarkos, Michail, Salmanton-García, Jon, Marchesi, Francesco, Gomes da Silva, Maria, Farina, Francesca, Dávila-Valls, Julio, Bilgin, Yavuz M., Glenthøj, Andreas, Falces-Romero, Iker, Van Doesum, Jaap, Labrador, Jorge, Buquicchio, Caterina, El-Ashwah, Shaimaa, Petzer, Verena, Van Praet, Jens, Schönlein, Martin, Dargenio, Michelina, Méndez, Gustavo-Adolfo, Meers, Stef, Itri, Federico, Giordano, Antonio, Pinczés, László Imre, Espigado, Ildefonso, Stojanoski, Zlate, López-García, Alberto, Prezioso, Lucia, Jaksic, Ozren, Vena, Antonio, Fracchiolla, Nicola S., González-López, Tomás José, Colović, Natasa, Delia, Mario, Weinbergerová, Barbora, Marchetti, Monia, Marques de Almeida, Joyce, Finizio, Olimpia, Besson, Caroline, Biernat, Monika M., Valković, Toni, Lahmer, Tobias, Cuccaro, Annarosa, Ormazabal-Vélez, Irati, Batinić, Josip, Fernández, Noemí, De Jonge, Nick, Tascini, Carlo, Anastasopoulou, Amalia N., Duléry, Rémy, Del Principe, Maria Ilaria, Plantefeve, Gaëtan, Papa, Mario Virgilio, Nucci, Marcio, Jiménez, Moraima, Aujayeb, Avinash, Hernández-Rivas, José-Ángel, Merelli, Maria, Cattaneo, Chiara, Blennow, Ola, Nordlander, Anna, Cabirta, Alba, Varricchio, Gina, Sacchi, Maria Vittoria, Cordoba, Raul, Arellano, Elena, Gräfe, Stefanie K., Wolf, Dominik, Emarah, Ziad, Ammatuna, Emanuele, Hersby, Ditte Stampe, Martín-Pérez, Sonia, Nunes Rodrigues, Raquel, Rahimli, Laman, Pagano, Livio, and Cornely, Oliver A.

Published
2023
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12. Breakthrough COVID-19 in vaccinated patients with hematologic malignancies: results from the EPICOVIDEHA survey

Author

Serrano, Laura, Ribera-Santa Susana, José-María, Meletiadis, Joseph, Tsirigotis, Panagiotis, Coppola, Nicola, Mikulska, Malgorzata, Erben, Nurettin, Besson, Caroline, Merelli, Maria, González-López, Tomás-José, Loureiro-Amigo, Jorge, García-Vidal, Carolina, Kort, Elizabeth de, Cuccaro, Annarosa, Zompi, Sofia, Reizine, Florian, Finizio, Olimpia, Duléry, Rémy, Calbacho, Maria, Abu-Zeinah, Ghaith, Malak, Sandra, Zdziarski, Przemyslaw, Varrichio, Gina, Tragiannidis, Athanasios, Plantefeve, Gaëtan, Duarte, Rafael, Danion, François, Tisi, Maria Chiara, Sakellari, Ioanna, Karthaus, Meinholf, Groh, Ana, Fung, Monica, Emarah, Ziad, Coronel-Ayala, Omar-Francisco, Ann Chai, Louis Yi, Brehon, Mathias, Bonuomo, Valentina, Wolf, Dominik, Wittig, Jana, Vehreschild, Maria, Papa, Mario Virgilio, Neuhann, Julia, Jiménez-Lorenzo, María-Josefa, Grothe, Jan, Gavriilaki, Eleni, García-Sanz, Ramón, García-Poutón, Nicole, El-Ashwah, Shaimaa Saber, Eggerer, Matthias, Cordoba, Raul, Çolak, Gökçe Melis, Arellano, Elena, Pagano, Livio, Salmanton-García, Jon, Marchesi, Francesco, Blennow, Ola, Gomes da Silva, Maria, Glenthøj, Andreas, van Doesum, Jaap, Bilgin, Yavuz M., López-García, Alberto, Itri, Federico, Nunes Rodrigues, Raquel, Weinbergerová, Barbora, Farina, Francesca, Dragonetti, Giulia, Berg Venemyr, Caroline, van Praet, Jens, Jaksic, Ozren, Valković, Toni, Falces-Romero, Iker, Martín-Pérez, Sonia, Jiménez, Moraima, Dávila-Valls, Julio, Schönlein, Martin, Ammatuna, Emanuele, Meers, Stef, Delia, Mario, Stojanoski, Zlate, Nordlander, Anna, Lahmer, Tobias, Imre Pinczés, László, Buquicchio, Caterina, Piukovics, Klára, Ormazabal-Vélez, Irati, Fracchiolla, Nicola, Samarkos, Michail, Méndez, Gustavo-Adolfo, Hernández-Rivas, José-Ángel, Espigado, Ildefonso, Cernan, Martin, Petzer, Verena, Lamure, Sylvain, di Blasi, Roberta, Marques de Almedia, Joyce, Dargenio, Michelina, Biernat, Monika M., Sciumè, Mariarita, de Ramón, Cristina, de Jonge, Nick, Batinić, Josip, Aujayeb, Avinash, Marchetti, Monia, Fouquet, Guillemette, Fernández, Noemí, Zambrotta, Giovanni, Sacchi, Maria Vittoria, Guidetti, Anna, Demirkan, Fatih, Prezioso, Lucia, Ráčil, Zdeněk, Nucci, Marcio, Mladenović, Miloš, Liévin, Raphaël, Hanáková, Michaela, Gräfe, Stefanie, Sili, Uluhan, Machado, Marina, Cattaneo, Chiara, Adžić-Vukičević, Tatjana, Verga, Luisa, Labrador, Jorge, Rahimli, Laman, Bonanni, Matteo, Passamonti, Francesco, Pagliuca, Antonio, Corradini, Paolo, Hoenigl, Martin, Koehler, Philipp, Busca, Alessandro, and Cornely, Oliver A.

Published
2022
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14. Evans syndrome in adults: an observational multicenter study

Author

Fattizzo, Bruno, Michel, Marc, Giannotta, Juri Alessandro, Hansen, Dennis Lund, Arguello, Maria, Sutto, Emanuele, Bianchetti, Nicola, Patriarca, Andrea, Cantoni, Silvia, Mingot-Castellano, María Eva, McDonald, Vickie, Capecchi, Marco, Zaninoni, Anna, Consonni, Dario, Vos, Josephine Mathilde, Vianelli, Nicola, Chen, Frederick, Glenthøj, Andreas, Frederiksen, Henrik, González-López, Tomás José, and Barcellini, Wilma

Published
2021
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17. Classification of Α-Thalassemia Data Using Machine Learning Models

Author

Christensen, Frederik, primary, Kılıç, Deniz Kenan, additional, Nielsen, Izabela Ewa, additional, El-Galaly, Tarec Christoffer, additional, Glenthoj, Andreas, additional, Helby, Jens, additional, Frederiksen, Hendrik, additional, Möller, Sören, additional, and Fuglkjær, Alexander Djupnes, additional

Published
2024
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19. Molnupiravir Compared to Nirmatrelvir/Ritonavir for COVID-19 in High-Risk Patients with Haematological Malignancy in Europe. A Matched-Paired Analysis from the Epicovideha Registry

Author

Salmanton-Garcia, Jon, primary, Marchesi, Francesco, additional, Koehler, Philipp, additional, Weinbergerova, Barbora, additional, Čolovic, Natasa, additional, Falces-Romero, Iker, additional, Buquicchio, Caterina, additional, Farina, Francesca, additional, Van Praet, Jens, additional, Biernat, Monika M., additional, Itri, Federico, additional, Prezioso, Lucia, additional, Tascini, Carlo, additional, Vena, Antonio, additional, Romano, Alessandra, additional, Delia, Mario, additional, Davila-Valls, Julio, additional, Martín-Pérez, Sonia, additional, Lavilla-Rubira, Esperanza, additional, Adzic, Tatjana N., additional, Garcia-Bordado, Daniel, additional, Lopez-Garcia, Alberto, additional, Criscuolo, Mariana, additional, Petzer, Verena, additional, Fracchiolla, Nicola S., additional, Espigado, Ildefonso, additional, Sili, Uluhan, additional, Meers, Stef, additional, Erben, Nurettin, additional, Cattaneo, Chiara, additional, Tragiannidis, Athanasios, additional, Gavriilaki, Eleni, additional, Schönlein, Martin, additional, Mitrovic, Mirjana, additional, Pantic, Nikola, additional, Merelli, Maria, additional, Labrador, Jorge, additional, Hernández-Rivas, Jose Angel, additional, Glenthoj, Andreas, additional, Fouquet, Guillemette, additional, del Principe, Maria Ilaria, additional, Dargenio, Michelina, additional, Calbacho, Maria, additional, Besson, Caroline, additional, Kohn, Milena, additional, Grafe, Stefanie K., additional, Hersby, Ditte Stampe, additional, Arellano, Elena, additional, Çolak, Gökçe Melis, additional, Wolf, Dominik, additional, Marchetti, Monia, additional, Nordlander, Anna, additional, Blennow, Ola, additional, Cordoba, Raul, additional, Miskovic, Bojana, additional, Mladenovic, Miloš, additional, Bavastro, Martina, additional, LIMONGELLI, Alessandro, additional, Rahimli, Laman, additional, Pagano, Livio, additional, and Cornely, Oliver A., additional

Published
2023
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20. Autoimmune hemolytic anemia during pregnancy and puerperium: an international multicenter experience

Author

Fattizzo, Bruno, Bortolotti, Marta, Fantini, Norma N., Glenthøj, Andreas, Michel, Marc, Napolitano, Mariasanta, Raso, Simona, Chen, Frederick, McDonald, Vickie, Murakhovskaya, Irina, Vos, Josephine Mathilde Iris, Patriarca, Andrea, Mingot-Castellano, Maria Eva, Giordano, Giulio, Scarrone, Margherita, González-López, Tomás José, Trespidi, Laura, Prati, Daniele, and Barcellini, Wilma

Published
2023
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24. Long-Term Hemoglobin Response and Reduction in Transfusion Burden Are Maintained in Patients with Pyruvate Kinase Deficiency Treated with Mitapivat

Author

Grace, Rachael F., Glenthøj, Andreas, Barcellini, Wilma, Verhovsek, Madeleine, Rothman, Jennifer A., Morado, Marta, Layton, D. Mark, Andres, Oliver, Galactéros, Frédéric, van Beers, Eduard J., Onodera, Koichi, Viprakasit, Vip, Chonat, Satheesh, Judge, Malia P., Kosinski, Penelope A., Hawkins, Peter, Gheuens, Sarah, Xu, Emily, McGee, Bryan, Beynon, Vanessa, and Al-Samkari, Hanny

Published
2022
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29. Simultaneous Onset of Haematological Malignancy and COVID: An Epicovideha Survey

Author

Cattaneo, Chiara, Salmanton-Garcia, Jon, Marchesi, Francesco, El-Ashwah, Shaimaa, Itri, Federico, Weinbergerova, Barbora, Da Silva, Maria Gomes, Dargenio, Michelina, Davila-Valls, Julio, Martin-Perez, Sonia, Farina, Francesca, Van Doesum, Jaap, Valkovic, Toni, Besson, Caroline, Poulsen, Christian Bjorn, Lopez-Garcia, Alberto, Zak, Pavel, Schonlein, Martin, Piukovics, Klara, Jaksic, Ozren, Cabirta, Alba, Ali, Natasha, Sili, Uluhan, Fracchiolla, Nicola, Dragonetti, Giulia, Adzic-Vukicevic, Tatjana, Marchetti, Monia, Machado, Marina, Glenthoj, Andreas, Finizio, Olimpia, Demirkan, Fatih, Blennow, Ola, Tisi, Maria Chiara, Omrani, Ali S., Navratil, Milan, Racil, Zdenek, Novak, Jan, Magliano, Gabriele, Jimenez, Moraima, Garcia-Vidal, Carolina, Erben, Nurettin, Del Principe, Maria Ilaria, Buquicchio, Caterina, Bergantim, Rui, Batinic, Josip, Al-Khabori, Murtadha, Verga, Luisa, Szotkowski, Tomas, Samarkos, Michail, Ormazabal-Velez, Irati, Meers, Stef, Maertens, Johan, Pinczes, Laszlo Imre, Hoenigl, Martin, Drgona, L'ubos, Cuccaro, Annarosa, Bilgin, Yavuz M., Aujayeb, Avinash, Rahimli, Laman, Grafe, Stefanie, Sciume, Mariarita, Mladenovic, Milos, Colak, Gokce Melis, Sacchi, Maria Vittoria, Nordlander, Anna, Venemyr, Caroline Berg, Hanakova, Michaela, Garcia-Pouton, Nicole, Emarah, Ziad, Zambrotta, Giovanni Paolo Maria, Rodrigues, Raquel Nunes, Cordoba, Raul, Mendez, Gustavo-Adolfo, Biernat, Monika M., Cornely, Oliver A., Pagano, Livio, Cattaneo, Chiara, Salmanton-Garcia, Jon, Marchesi, Francesco, El-Ashwah, Shaimaa, Itri, Federico, Weinbergerova, Barbora, Da Silva, Maria Gomes, Dargenio, Michelina, Davila-Valls, Julio, Martin-Perez, Sonia, Farina, Francesca, Van Doesum, Jaap, Valkovic, Toni, Besson, Caroline, Poulsen, Christian Bjorn, Lopez-Garcia, Alberto, Zak, Pavel, Schonlein, Martin, Piukovics, Klara, Jaksic, Ozren, Cabirta, Alba, Ali, Natasha, Sili, Uluhan, Fracchiolla, Nicola, Dragonetti, Giulia, Adzic-Vukicevic, Tatjana, Marchetti, Monia, Machado, Marina, Glenthoj, Andreas, Finizio, Olimpia, Demirkan, Fatih, Blennow, Ola, Tisi, Maria Chiara, Omrani, Ali S., Navratil, Milan, Racil, Zdenek, Novak, Jan, Magliano, Gabriele, Jimenez, Moraima, Garcia-Vidal, Carolina, Erben, Nurettin, Del Principe, Maria Ilaria, Buquicchio, Caterina, Bergantim, Rui, Batinic, Josip, Al-Khabori, Murtadha, Verga, Luisa, Szotkowski, Tomas, Samarkos, Michail, Ormazabal-Velez, Irati, Meers, Stef, Maertens, Johan, Pinczes, Laszlo Imre, Hoenigl, Martin, Drgona, L'ubos, Cuccaro, Annarosa, Bilgin, Yavuz M., Aujayeb, Avinash, Rahimli, Laman, Grafe, Stefanie, Sciume, Mariarita, Mladenovic, Milos, Colak, Gokce Melis, Sacchi, Maria Vittoria, Nordlander, Anna, Venemyr, Caroline Berg, Hanakova, Michaela, Garcia-Pouton, Nicole, Emarah, Ziad, Zambrotta, Giovanni Paolo Maria, Rodrigues, Raquel Nunes, Cordoba, Raul, Mendez, Gustavo-Adolfo, Biernat, Monika M., Cornely, Oliver A., and Pagano, Livio

Abstract

Simple Summary Patients with simultaneous diagnosis of haematological malignancies (HM) and COVID-19 are an even greater challenge for hematologists. To better clarify their outcome, we describe the clinical features and outcome of a cohort of 450 patients with simultaneous diagnosis of HM and COVID-19 registered in the EPICOVIDEHA registry between March 2020 to February 2022. Overall, 343 (76.2%) patients received treatment for HM, and an overall response rate was observed in 140 (40.8%) patients after the first line of treatment. Thirty-day mortality was significantly higher in patients not receiving HM treatment (42.1%) than in those receiving treatment (27.4%, p = 0.004). Statistical analysis showed that, together with age, severe/critical COVID-19, >= 2 comorbidities, lack of HM treatment was an independent risk factors for mortality. These observations suggest the importance of HM treatment in these patients; therefore, it should be delivered as soon as possible for patients requiring immediate therapy. Background: The outcome of patients with simultaneous diagnosis of haematological malignancies (HM) and COVID-19 is unknown and there are no specific treatment guidelines. Methods: We describe the clinical features and outcome of a cohort of 450 patients with simultaneous diagnosis of HM and COVID-19 registered in the EPICOVIDEHA registry between March 2020 to February 2022. Results: Acute leukaemia and lymphoma were the most frequent HM (35.8% and 35.1%, respectively). Overall, 343 (76.2%) patients received treatment for HM, which was delayed for longer than one month since diagnosis in 57 (16.6%). An overall response rate was observed in 140 (40.8%) patients after the first line of treatment. After a median follow-up of 35 days, overall mortality was 177/450 (39.3%); 30-day mortality was significantly higher in patients not receiving HM treatment (42.1%) than in those receiving treatment (27.4%, p = 0.004), either before and/or after COVID-19, or compared to

Published
2022

30. B-cell malignancies treated with targeted drugs and SARS-CoV-2 infection: A European Hematology Association Survey (EPICOVIDEHA)

Author

Infante, Maria Stefania, Salmanton-Garcia, Jon, Fernandez-Cruz, Ana, Marchesi, Francesco, Jaksic, Ozren, Weinbergerova, Barbora, Besson, Caroline, Duarte, Rafael F., Itri, Federico, Valkovic, Toni, Szotkovski, Tomas, Busca, Alessandro, Guidetti, Anna, Glenthoj, Andreas, Collins, Graham P., Bonuomo, Valentina, Sili, Uluhan, Seval, Guldane Cengiz, Machado, Marina, Cordoba, Raul, Blennow, Ola, Abu-Zeinah, Ghaith, Lamure, Sylvain, Kulasekararaj, Austin, Falces-Romero, Iker, Cattaneo, Chiara, Van Doesum, Jaap, Piukovics, Klara, Omrani, Ali S., Magliano, Gabriele, Ledoux, Marie-Pierre, de Ramon, Cristina, Cabirta, Alba, Verga, Luisa, Lopez-Garcia, Alberto, Da Silva, Maria Gomes, Stojanoski, Zlate, Meers, Stef, Lahmer, Tobias, Martin-Perez, Sonia, Davila-Vals, Julio, Van Praet, Jens, Samarkos, Michail, Bilgin, Yavuz M., Karlsson, Linda Katharina, Batinic, Josip, Nordlander, Anna, Schonlein, Martin, Hoenigl, Martin, Racil, Zdenek, Mladenovic, Milos, Hanakova, Michaela, Zambrotta, Giovanni Paolo Maria, De Jonge, Nick, Adzic-Vukicevic, Tatjana, Nunes-Rodrigues, Raquel, Prezioso, Lucia, Navratil, Milan, Marchetti, Monia, Cuccaro, Annarosa, Calbacho, Maria, Giordano, Antonio, Cornely, Oliver A., Hernandez-Rivas, Jose-Angel, Pagano, Livio, Infante, Maria Stefania, Salmanton-Garcia, Jon, Fernandez-Cruz, Ana, Marchesi, Francesco, Jaksic, Ozren, Weinbergerova, Barbora, Besson, Caroline, Duarte, Rafael F., Itri, Federico, Valkovic, Toni, Szotkovski, Tomas, Busca, Alessandro, Guidetti, Anna, Glenthoj, Andreas, Collins, Graham P., Bonuomo, Valentina, Sili, Uluhan, Seval, Guldane Cengiz, Machado, Marina, Cordoba, Raul, Blennow, Ola, Abu-Zeinah, Ghaith, Lamure, Sylvain, Kulasekararaj, Austin, Falces-Romero, Iker, Cattaneo, Chiara, Van Doesum, Jaap, Piukovics, Klara, Omrani, Ali S., Magliano, Gabriele, Ledoux, Marie-Pierre, de Ramon, Cristina, Cabirta, Alba, Verga, Luisa, Lopez-Garcia, Alberto, Da Silva, Maria Gomes, Stojanoski, Zlate, Meers, Stef, Lahmer, Tobias, Martin-Perez, Sonia, Davila-Vals, Julio, Van Praet, Jens, Samarkos, Michail, Bilgin, Yavuz M., Karlsson, Linda Katharina, Batinic, Josip, Nordlander, Anna, Schonlein, Martin, Hoenigl, Martin, Racil, Zdenek, Mladenovic, Milos, Hanakova, Michaela, Zambrotta, Giovanni Paolo Maria, De Jonge, Nick, Adzic-Vukicevic, Tatjana, Nunes-Rodrigues, Raquel, Prezioso, Lucia, Navratil, Milan, Marchetti, Monia, Cuccaro, Annarosa, Calbacho, Maria, Giordano, Antonio, Cornely, Oliver A., Hernandez-Rivas, Jose-Angel, and Pagano, Livio

Abstract

Patients with lymphoproliferative diseases (LPD) are vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Here, we describe and analyze the outcome of 366 adult patients with chronic lymphocytic leukemia (CLL) or non-Hodgkin Lymphoma (NHL) treated with targeted drugs and laboratory-confirmed COVID-19 diagnosed between February 2020 and January 2022. Median follow-up was 70.5 days (IQR 0-609). Most used targeted drugs were Bruton-kinase inhibitors (BKIs) (N= 201, 55%), anti-CD20 other than rituximab (N=61, 16%), BCL2 inhibitors (N=33, 9%) and lenalidomide (N=28, 8%).Only 16.2% of the patients were vaccinated with 2 or more doses of vaccine at the onset of COVID-19. Mortality was 24% (89/366) on day 30 and 36%(134/366) on the last day of follow-up. Age >75 years (p<0.001, HR 1.036), active malignancy (p<0.001, HR 2.215), severe COVID-19 (p=0.017, HR 2.270) and admission to ICU (p<0.001, HR 5.751) were risk factors for mortality at last day of follow up. There was no difference in OS rates in NHL vs CLL patients (p=0.306), nor in patients treated with or without BKIs (p=0.151). Mortality in ICU was 66% (CLL 61%, NHL 76%). Overall mortality rate decreased according to vaccination status, being 39% in unvaccinated patients, 32% and 26% in those having received one or two doses, respectively, and 20% in patients with a booster dose (p=0.245). Overall mortality rate dropped from 41% during the first semester of 2020 to 25% at the last semester of 2021. These results show increased severity and mortality from COVID-19 in LPDs patients treated with targeted drugs.

Published
2022

31. Breakthrough COVID-19 in vaccinated patients with hematologic malignancies: results from the EPICOVIDEHA survey

Author

Pagano, Livio, Salmanton-Garcia, Jon, Marchesi, Francesco, Blennow, Ola, da Silva, Maria Gomes, Glenthoj, Andreas, van Doesum, Jaap, Bilgin, Yavuz M., Lopez-Garcia, Alberto, Itri, Federico, Rodrigues, Raquel Nunes, Weinbergerova, Barbora, Farina, Francesca, Dragonetti, Giulia, Venemyr, Caroline Berg, van Praet, Jens, Jaksic, Ozren, Valkovic, Toni, Falces-Romero, Iker, Martin-Perez, Sonia, Jimenez, Moraima, Davila-Valls, Julio, Schonlein, Martin, Ammatuna, Emanuele, Meers, Stef, Delia, Mario, Stojanoski, Zlate, Nordlander, Anna, Lahmer, Tobias, Pinczes, Laszlo Imre, Buquicchio, Caterina, Piukovics, Klara, Ormazabal-Velez, Irati, Fracchiolla, Nicola, Samarkos, Michail, Mendez, Gustavo-Adolfo, Hernandez-Rivas, Jose-Angel, Espigado, Ildefonso, Cernan, Martin, Petzer, Verena, Lamure, Sylvain, di Blasi, Roberta, de Almedia, Joyce Marques, Dargenio, Michelina, Biernat, Monika M., Sciume, Mariarita, de Ramon, Cristina, de Jonge, Nick, Batinic, Josip, Aujayeb, Avinash, Marchetti, Monia, Fouquet, Guillemette, Fernandez, Noemi, Zambrotta, Giovanni, Sacchi, Maria Vittoria, Guidetti, Anna, Demirkan, Fatih, Prezioso, Lucia, Racil, Zdenek, Nucci, Marcio, Mladenovic, Milos, Lievin, Raphael, Hanakova, Michaela, Grafe, Stefanie, Sili, Uluhan, Machado, Marina, Cattaneo, Chiara, Adzic-Vukicevic, Tatjana, Verga, Luisa, Labrador, Jorge, Rahimli, Laman, Bonanni, Matteo, Passamonti, Francesco, Pagliuca, Antonio, Corradini, Paolo, Hoenigl, Martin, Koehler, Philipp, Busca, Alessandro, Cornely, Oliver A., Pagano, Livio, Salmanton-Garcia, Jon, Marchesi, Francesco, Blennow, Ola, da Silva, Maria Gomes, Glenthoj, Andreas, van Doesum, Jaap, Bilgin, Yavuz M., Lopez-Garcia, Alberto, Itri, Federico, Rodrigues, Raquel Nunes, Weinbergerova, Barbora, Farina, Francesca, Dragonetti, Giulia, Venemyr, Caroline Berg, van Praet, Jens, Jaksic, Ozren, Valkovic, Toni, Falces-Romero, Iker, Martin-Perez, Sonia, Jimenez, Moraima, Davila-Valls, Julio, Schonlein, Martin, Ammatuna, Emanuele, Meers, Stef, Delia, Mario, Stojanoski, Zlate, Nordlander, Anna, Lahmer, Tobias, Pinczes, Laszlo Imre, Buquicchio, Caterina, Piukovics, Klara, Ormazabal-Velez, Irati, Fracchiolla, Nicola, Samarkos, Michail, Mendez, Gustavo-Adolfo, Hernandez-Rivas, Jose-Angel, Espigado, Ildefonso, Cernan, Martin, Petzer, Verena, Lamure, Sylvain, di Blasi, Roberta, de Almedia, Joyce Marques, Dargenio, Michelina, Biernat, Monika M., Sciume, Mariarita, de Ramon, Cristina, de Jonge, Nick, Batinic, Josip, Aujayeb, Avinash, Marchetti, Monia, Fouquet, Guillemette, Fernandez, Noemi, Zambrotta, Giovanni, Sacchi, Maria Vittoria, Guidetti, Anna, Demirkan, Fatih, Prezioso, Lucia, Racil, Zdenek, Nucci, Marcio, Mladenovic, Milos, Lievin, Raphael, Hanakova, Michaela, Grafe, Stefanie, Sili, Uluhan, Machado, Marina, Cattaneo, Chiara, Adzic-Vukicevic, Tatjana, Verga, Luisa, Labrador, Jorge, Rahimli, Laman, Bonanni, Matteo, Passamonti, Francesco, Pagliuca, Antonio, Corradini, Paolo, Hoenigl, Martin, Koehler, Philipp, Busca, Alessandro, and Cornely, Oliver A.

Abstract

Limited data are available on breakthrough COVID-19 in patients with hematologic malignancy (HM) after anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) vaccination. Adult patients with HM, >= 1 dose of anti-SARS-CoV-2 vaccine, and breakthrough COVID-19 between January 2021 and March 2022 were analyzed. A total of 1548 cases were included, mainly lymphoid malignancies (1181 cases, 76%). After viral sequencing in 753 cases (49%), the Omicron variant was prevalent (517, 68.7%). Most of the patients received <= 2 vaccine doses before COVID-19 (1419, 91%), mostly mRNAbased (1377, 89%). Overall, 906 patients (59%) received COVID-19-specific treatment. After 30-day follow-up from COVID-19 diagnosis, 143 patients (9%) died. The mortality rate in patients with the Omicron variant was 7.9%, comparable to other variants, with a significantly lower 30-day mortality rate than in the prevaccine era (31%). In the univariable analysis, older age (P <.001), active HM (P <.001), and severe and critical COVID-19 (P =.007 and P <.001, respectively) were associated with mortality. Conversely, patients receiving monoclonal antibodies, even for severe or critical COVID-19, had a lower mortality rate (P <.001). In the multivariable model, older age, active disease, critical COVID-19, and 2-3 comorbidities were correlated with a higher mortality, whereas monoclonal antibody administration, alone (P <.001) or combined with antivirals (P =.009), was protective. Although mortality is significantly lower than in the prevaccination era, breakthrough COVID-19 in HM is still associated with considerable mortality. Death rate was lower in patients who received monoclonal antibodies, alone or in combination with antivirals.

Published
2022

32. Improved Clinical Outcome of COVID-19 in Hematologic Malignancy Patients Receiving a Fourth Dose of Anti-SARS-CoV-2 Vaccine: An EPICOVIDEHA Report

Author

Salmanton-Garcia, Jon, Marchesi, Francesco, Glenthoj, Andreas, Bilgin, Yavuz M., van Praet, Jens, Davila-Valls, Julio, Martin-Perez, Sonia, Labrador, Jorge, van Doesum, Jaap, Falces-Romero, Iker, Farina, Francesca, Schoenlein, Martin, Chanut, Mathilde, Petzer, Verena, Espigado, Ildefonso, Dargenio, Michelina, Aujayeb, Avinash, Sili, Uluhan, Serrano, Laura, Pinczes, Laszlo Imre, de Jonge, Nick, Soto-Silva, Andres, Buquicchio, Caterina, Prezioso, Lucia, Marchetti, Monia, Meers, Stef, Busca, Alessandro, Corradini, Paolo, Hoenigl, Martin, Koehler, Philipp, Rahimli, Laman, Colak, Gokce Melis, Arellano, Elena, Wolf, Dominik, Graefe, Stefanie, Ammatuna, Emanuele, Venemyr, Caroline Berg, Cornely, Oliver A., Pagano, Livio, Salmanton-Garcia, Jon, Marchesi, Francesco, Glenthoj, Andreas, Bilgin, Yavuz M., van Praet, Jens, Davila-Valls, Julio, Martin-Perez, Sonia, Labrador, Jorge, van Doesum, Jaap, Falces-Romero, Iker, Farina, Francesca, Schoenlein, Martin, Chanut, Mathilde, Petzer, Verena, Espigado, Ildefonso, Dargenio, Michelina, Aujayeb, Avinash, Sili, Uluhan, Serrano, Laura, Pinczes, Laszlo Imre, de Jonge, Nick, Soto-Silva, Andres, Buquicchio, Caterina, Prezioso, Lucia, Marchetti, Monia, Meers, Stef, Busca, Alessandro, Corradini, Paolo, Hoenigl, Martin, Koehler, Philipp, Rahimli, Laman, Colak, Gokce Melis, Arellano, Elena, Wolf, Dominik, Graefe, Stefanie, Ammatuna, Emanuele, Venemyr, Caroline Berg, Cornely, Oliver A., and Pagano, Livio

Published
2022

33. COVID-19 in vaccinated adult patients with hematological malignancies: preliminary results from EPICOVIDEHA

Author

Pagano, Livio, Salmanton-Garc, Jon, Marchesi, Francesco, Lopez-Garcia, Alberto, Lamure, Sylvain, Itri, Federico, Gomes-Silva, Maria, Dragonetti, Giulia, Falces-Romero, Iker, van Doesum, Jaap, Sili, Uluhan, Labrador, Jorge, Calbacho, Maria, Bilgin, Yavuz M., Weinbergerova, Barbora, Serrano, Laura, Susana, Jose-Maria Ribera-Santa, Malak, Sandra, Loureiro-Amigo, Jose, Glenthoj, Andreas, Cordoba-Mascunano, Raul, Nunes-Rodrigues, Raquel, Gonzalez-Lopez, Tomas-Jose, Karlsson, Linda Katharina, Jimenez-Lorenzo, Maria-Josefa, Hernandez-Rivas, Jose-Angel, Jaksic, Ozren, Racil, Zdenek, Busca, Alessandro, Corradini, Paolo, Hoenigl, Martin, Klimko, Nikolai, Koehler, Philipp, Pagliuca, Antonio, Passamonti, Francesco, Cornely, Oliver A., Pagano, Livio, Salmanton-Garc, Jon, Marchesi, Francesco, Lopez-Garcia, Alberto, Lamure, Sylvain, Itri, Federico, Gomes-Silva, Maria, Dragonetti, Giulia, Falces-Romero, Iker, van Doesum, Jaap, Sili, Uluhan, Labrador, Jorge, Calbacho, Maria, Bilgin, Yavuz M., Weinbergerova, Barbora, Serrano, Laura, Susana, Jose-Maria Ribera-Santa, Malak, Sandra, Loureiro-Amigo, Jose, Glenthoj, Andreas, Cordoba-Mascunano, Raul, Nunes-Rodrigues, Raquel, Gonzalez-Lopez, Tomas-Jose, Karlsson, Linda Katharina, Jimenez-Lorenzo, Maria-Josefa, Hernandez-Rivas, Jose-Angel, Jaksic, Ozren, Racil, Zdenek, Busca, Alessandro, Corradini, Paolo, Hoenigl, Martin, Klimko, Nikolai, Koehler, Philipp, Pagliuca, Antonio, Passamonti, Francesco, and Cornely, Oliver A.

Published
2022

34. Outcome of infection with omicron SARS-CoV-2 variant in patients with hematological malignancies: An EPICOVIDEHA survey report

Author

Blennow, Ola, Salmanton-Garcia, Jon, Nowak, Piotr, Itri, Federico, Van Doesum, Jaap, Lopez-Garcia, Alberto, Farina, Francesca, Jaksic, Ozren, Pinczes, Laszlo Imre, Bilgin, Yavuz M., Falces-Romero, Iker, Jimenez, Moraima, Ormazabal-Velez, Irati, Weinbergerova, Barbora, Dulery, Remy, Stojanoski, Zlate, Lahmer, Tobias, Fernandez, Noemi, Hernandez-Rivas, Jose-angel, Petzer, Verena, De Jonge, Nick, Glenthoj, Andreas, De Ramon, Cristina, Biernat, Monika M., Fracchiolla, Nicola, Aujayeb, Avinash, Van Praet, Jens, Schonlein, Martin, Mendez, Gustavo-Adolfo, Cattaneo, Chiara, Guidetti, Anna, Sciume, Mariarita, Ammatuna, Emanuele, Cordoba, Raul, Garcia-Pouton, Nicole, Graefe, Stefanie, Cabirta, Alba, Wolf, Dominik, Nordlander, Anna, Garcia-Sanz, Ramon, Delia, Mario, Berg Venemyr, Caroline, Brones, Clara, Di Blasi, Roberta, De Kort, Elizabeth, Meers, Stef, Lamure, Sylvain, Serrano, Laura, Merelli, Maria, Coppola, Nicola, Bergantim, Rui, Besson, Caroline, Kohn, Milena, Petiti, Jessica, Garcia-Vidal, Carolina, Dargenio, Michelina, Danion, Francois, Machado, Marina, Bailen-Almorox, Rebeca, Hoenigl, Martin, Dragonetti, Giulia, Chai, Louis Yi Ann, Kho, Chi Shan, Bonanni, Matteo, Lievin, Raphael, Marchesi, Francesco, Cornely, Oliver A., Pagano, Livio, Blennow, Ola, Salmanton-Garcia, Jon, Nowak, Piotr, Itri, Federico, Van Doesum, Jaap, Lopez-Garcia, Alberto, Farina, Francesca, Jaksic, Ozren, Pinczes, Laszlo Imre, Bilgin, Yavuz M., Falces-Romero, Iker, Jimenez, Moraima, Ormazabal-Velez, Irati, Weinbergerova, Barbora, Dulery, Remy, Stojanoski, Zlate, Lahmer, Tobias, Fernandez, Noemi, Hernandez-Rivas, Jose-angel, Petzer, Verena, De Jonge, Nick, Glenthoj, Andreas, De Ramon, Cristina, Biernat, Monika M., Fracchiolla, Nicola, Aujayeb, Avinash, Van Praet, Jens, Schonlein, Martin, Mendez, Gustavo-Adolfo, Cattaneo, Chiara, Guidetti, Anna, Sciume, Mariarita, Ammatuna, Emanuele, Cordoba, Raul, Garcia-Pouton, Nicole, Graefe, Stefanie, Cabirta, Alba, Wolf, Dominik, Nordlander, Anna, Garcia-Sanz, Ramon, Delia, Mario, Berg Venemyr, Caroline, Brones, Clara, Di Blasi, Roberta, De Kort, Elizabeth, Meers, Stef, Lamure, Sylvain, Serrano, Laura, Merelli, Maria, Coppola, Nicola, Bergantim, Rui, Besson, Caroline, Kohn, Milena, Petiti, Jessica, Garcia-Vidal, Carolina, Dargenio, Michelina, Danion, Francois, Machado, Marina, Bailen-Almorox, Rebeca, Hoenigl, Martin, Dragonetti, Giulia, Chai, Louis Yi Ann, Kho, Chi Shan, Bonanni, Matteo, Lievin, Raphael, Marchesi, Francesco, Cornely, Oliver A., and Pagano, Livio

Published
2022

36. Papillon-Lefevre syndrome patient reveals species-dependent requirements for neutrophil defenses

Author

Sorensen, Ole E., Clemmensen, Stine N., Dahl, Sara L., Ostergaard, Ole, Heegaard, Niels H., Glenthoj, Andreas, Nielsen, Finn Cilius, and Borregaard, Niels

Subjects
Gene mutations -- Identification and classification, Papillon-Lefevre disease -- Genetic aspects -- Diagnosis, Cathepsins -- Genetic aspects, Health care industry
Abstract

Papillon-Lefevre syndrome (PLS) results from mutations that inactivate cysteine protease cathepsin C (CTSC), which processes a variety of serine proteases considered essential for antimicrobial defense. Despite serine protease-deficient immune cell populations, PLS patients do not exhibit marked immunodeficiency. Here, we characterized a 24-year-old woman who had suffered from severe juvenile periodontal disease, but was otherwise healthy, and identified a homozygous missense mutation in CTSC indicative of PLS. Proteome analysis of patient neutrophil granules revealed that several proteins that normally localize to azurophil granules, including the major serine proteases, elastase, cathepsin G, and proteinase 3, were absent. Accordingly, neutrophils from this patient were incapable of producing neutrophil extracellular traps (NETs) in response to ROS and were unable to process endogenous cathelicidin hCAP-18 into the antibacterial peptide LL-37 in response to ionomycin. In immature myeloid cells from patient bone marrow, biosynthesis of CTSC and neutrophil serine proteases appeared normal along with initial processing and sorting to cellular storage. In contrast, these proteins were completely absent in mature neutrophils, indicating that CTSC mutation promotes protease degradation in more mature hematopoietic subsets, but does not affect protease production in progenitor cells. Together, these data indicate CTSC protects serine proteases from degradation in mature immune cells and suggest that neutrophil serine proteases are dispensable for human immunoprotection., Introduction Papillon-Lefevre Syndrome (PLS) is a rare autosomal recessive disease caused by mutations in the gene encoding lysosomal cysteine protease cathepsin C (CTSC) (1-3), also known as dipeptidyl peptidase I [...]

Published
2014
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38. COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study

Author

Chatzikonstantinou, Thomas Kapetanakis, Anargyros Scarfo, Lydia and Karakatsoulis, Georgios Allsup, David Alonso Cabrero, Alejandro Andres, Martin Antic, Darko Baile, Monica and Baliakas, Panagiotis Bron, Dominique Capasso, Antonella and Chatzileontiadou, Sofia Cordoba, Raul Correa, Juan-Gonzalo and Cuellar-Garcia, Carolina De Paoli, Lorenzo De Paolis, Maria Rosaria Del Poeta, Giovanni Demosthenous, Christos Dimou, Maria Donaldson, David Doubek, Michael Efstathopoulou, Maria and Eichhorst, Barbara El-Ashwah, Shaimaa Enrico, Alicia and Espinet, Blanca Farina, Lucia Ferrari, Angela Foglietta, Myriam Frederiksen, Henrik Furstenau, Moritz Garcia-Marco, Jose A. Garcia-Serra, Rocio Gentile, Massimo Gimeno, Eva and Glenthoj, Andreas da Silva, Maria Gomes Gutwein, Odit and Hakobyan, Yervand K. Herishanu, Yair Angel Hernandez-Rivas, Jose and Herold, Tobias Innocenti, Idanna Itchaki, Gilad Jaksic, Ozren Janssens, Ann Kalashnikova, Olga B. Kalicinska, Elzbieta Karlsson, Linda Katharina Kater, Arnon P. Kersting, Sabina Labrador, Jorge Lad, Deepesh Laurenti, Luca and Levin, Mark-David Lista, Enrico Lopez-Garcia, Alberto and Malerba, Lara Marasca, Roberto Marchetti, Monia Marquet, Juan Mattsson, Mattias Mauro, Francesca R. Milosevic, Ivana and Miras, Fatima Morawska, Marta Motta, Marina Munir, Talha and Murru, Roberta Niemann, Carsten U. Rodrigues, Raquel Nunes and Olivieri, Jacopo Orsucci, Lorella Papaioannou, Maria and Arturo Pavlovsky, Miguel Piskunova, Inga Popov, Viola Maria and Quaglia, Francesca Maria Quaresmini, Giulia Qvist, Kristian and Reda, Gianluigi Rigolin, Gian Matteo Ruchlemer, Rosa and Saghumyan, Gevorg Shrestha, Amit Simkovic, Martin Spacek, Martin Sportoletti, Paolo Stanca, Oana Stavroyianni, Niki and Tadmor, Tamar Te Raa, Doreen Tonino, Sanne H. Trentin, Livio Van der Spek, Ellen van Gelder, Michel van Kampen, Roel Varettoni, Marzia Visentin, Andrea Vitale, Candida and Wasik-Szczepanek, Ewa Wrobel, Tomasz Yanez San Segundo, Lucrecia and Yassin, Mohamed Coscia, Marta Rambaldi, Alessandro and Montserrat, Emili Foa, Robin Cuneo, Antonio Stamatopoulos, Kostas Ghia, Paolo

Abstract

Patients with chronic lymphocytic leukemia (CLL) may be more susceptible to Coronavirus disease 2019 (COVID-19) due to age, disease, and treatment-related immunosuppression. We aimed to assess risk factors of outcome and elucidate the impact of CLL-directed treatments on the course of COVID-19. We conducted a retrospective, international study, collectively including 941 patients with CLL and confirmed COVID-19. Data from the beginning of the pandemic until March 16, 2021, were collected from 91 centers. The risk factors of case fatality rate (CFR), disease severity, and overall survival (OS) were investigated. OS analysis was restricted to patients with severe COVID-19 (definition: hospitalization with need of oxygen or admission into an intensive care unit). CFR in patients with severe COVID-19 was 38.4%. OS was inferior for patients in all treatment categories compared to untreated (p < 0.001). Untreated patients had a lower risk of death (HR = 0.54, 95% CI:0.41-0.72). The risk of death was higher for older patients and those suffering from cardiac failure (HR = 1.03, 95% CI:1.02-1.04; HR = 1.79, 95% CI:1.04-3.07, respectively). Age, CLL-directed treatment, and cardiac failure were significant risk factors of OS. Untreated patients had a better chance of survival than those on treatment or recently treated.

Published
2021

39. COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study

Author

Chatzikonstantinou, Thomas, Kapetanakis, Anargyros, Scarfo, Lydia, Karakatsoulis, Georgios, Allsup, David, Alonso Cabrero, Alejandro, Andres, Martin, Antic, Darko, Baile, Monica, Baliakas, Panagiotis, Bron, Dominique, Capasso, Antonella, Chatzileontiadou, Sofia, Cordoba, Raul, Correa, Juan-Gonzalo, Cuellar-Garcia, Carolina, De Paoli, Lorenzo, De Paolis, Maria Rosaria, Del Poeta, Giovanni, Demosthenous, Christos, Dimou, Maria, Donaldson, David, Doubek, Michael, Efstathopoulou, Maria, Eichhorst, Barbara, El-Ashwah, Shaimaa, Enrico, Alicia, Espinet, Blanca, Farina, Lucia, Ferrari, Angela, Foglietta, Myriam, Frederiksen, Henrik, Furstenau, Moritz, Garcia-Marco, Jose A., Garcia-Serra, Rocio, Gentile, Massimo, Gimeno, Eva, Glenthoj, Andreas, da Silva, Maria Gomes, Gutwein, Odit, Hakobyan, Yervand K., Herishanu, Yair, Angel Hernandez-Rivas, Jose, Herold, Tobias, Innocenti, Idanna, Itchaki, Gilad, Jaksic, Ozren, Janssens, Ann, Kalashnikova, Olga B., Kalicinska, Elzbieta, Karlsson, Linda Katharina, Kater, Arnon P., Kersting, Sabina, Labrador, Jorge, Lad, Deepesh, Laurenti, Luca, Levin, Mark-David, Lista, Enrico, Lopez-Garcia, Alberto, Malerba, Lara, Marasca, Roberto, Marchetti, Monia, Marquet, Juan, Mattsson, Mattias, Mauro, Francesca R., Milosevic, Ivana, Miras, Fatima, Morawska, Marta, Motta, Marina, Munir, Talha, Murru, Roberta, Niemann, Carsten U., Rodrigues, Raquel Nunes, Olivieri, Jacopo, Orsucci, Lorella, Papaioannou, Maria, Arturo Pavlovsky, Miguel, Piskunova, Inga, Popov, Viola Maria, Quaglia, Francesca Maria, Quaresmini, Giulia, Qvist, Kristian, Reda, Gianluigi, Rigolin, Gian Matteo, Ruchlemer, Rosa, Saghumyan, Gevorg, Shrestha, Amit, Simkovic, Martin, Spacek, Martin, Sportoletti, Paolo, Stanca, Oana, Stavroyianni, Niki, Tadmor, Tamar, Te Raa, Doreen, Tonino, Sanne H., Trentin, Livio, Van der Spek, Ellen, van Gelder, Michel, van Kampen, Roel, Varettoni, Marzia, Visentin, Andrea, Vitale, Candida, Wasik-Szczepanek, Ewa, Wrobel, Tomasz, Yanez San Segundo, Lucrecia, Yassin, Mohamed, Coscia, Marta, Rambaldi, Alessandro, Montserrat, Emili, Foa, Robin, Cuneo, Antonio, Stamatopoulos, Kostas, Ghia, Paolo, Chatzikonstantinou, Thomas, Kapetanakis, Anargyros, Scarfo, Lydia, Karakatsoulis, Georgios, Allsup, David, Alonso Cabrero, Alejandro, Andres, Martin, Antic, Darko, Baile, Monica, Baliakas, Panagiotis, Bron, Dominique, Capasso, Antonella, Chatzileontiadou, Sofia, Cordoba, Raul, Correa, Juan-Gonzalo, Cuellar-Garcia, Carolina, De Paoli, Lorenzo, De Paolis, Maria Rosaria, Del Poeta, Giovanni, Demosthenous, Christos, Dimou, Maria, Donaldson, David, Doubek, Michael, Efstathopoulou, Maria, Eichhorst, Barbara, El-Ashwah, Shaimaa, Enrico, Alicia, Espinet, Blanca, Farina, Lucia, Ferrari, Angela, Foglietta, Myriam, Frederiksen, Henrik, Furstenau, Moritz, Garcia-Marco, Jose A., Garcia-Serra, Rocio, Gentile, Massimo, Gimeno, Eva, Glenthoj, Andreas, da Silva, Maria Gomes, Gutwein, Odit, Hakobyan, Yervand K., Herishanu, Yair, Angel Hernandez-Rivas, Jose, Herold, Tobias, Innocenti, Idanna, Itchaki, Gilad, Jaksic, Ozren, Janssens, Ann, Kalashnikova, Olga B., Kalicinska, Elzbieta, Karlsson, Linda Katharina, Kater, Arnon P., Kersting, Sabina, Labrador, Jorge, Lad, Deepesh, Laurenti, Luca, Levin, Mark-David, Lista, Enrico, Lopez-Garcia, Alberto, Malerba, Lara, Marasca, Roberto, Marchetti, Monia, Marquet, Juan, Mattsson, Mattias, Mauro, Francesca R., Milosevic, Ivana, Miras, Fatima, Morawska, Marta, Motta, Marina, Munir, Talha, Murru, Roberta, Niemann, Carsten U., Rodrigues, Raquel Nunes, Olivieri, Jacopo, Orsucci, Lorella, Papaioannou, Maria, Arturo Pavlovsky, Miguel, Piskunova, Inga, Popov, Viola Maria, Quaglia, Francesca Maria, Quaresmini, Giulia, Qvist, Kristian, Reda, Gianluigi, Rigolin, Gian Matteo, Ruchlemer, Rosa, Saghumyan, Gevorg, Shrestha, Amit, Simkovic, Martin, Spacek, Martin, Sportoletti, Paolo, Stanca, Oana, Stavroyianni, Niki, Tadmor, Tamar, Te Raa, Doreen, Tonino, Sanne H., Trentin, Livio, Van der Spek, Ellen, van Gelder, Michel, van Kampen, Roel, Varettoni, Marzia, Visentin, Andrea, Vitale, Candida, Wasik-Szczepanek, Ewa, Wrobel, Tomasz, Yanez San Segundo, Lucrecia, Yassin, Mohamed, Coscia, Marta, Rambaldi, Alessandro, Montserrat, Emili, Foa, Robin, Cuneo, Antonio, Stamatopoulos, Kostas, and Ghia, Paolo

Abstract

Patients with chronic lymphocytic leukemia (CLL) may be more susceptible to Coronavirus disease 2019 (COVID-19) due to age, disease, and treatment-related immunosuppression. We aimed to assess risk factors of outcome and elucidate the impact of CLL-directed treatments on the course of COVID-19. We conducted a retrospective, international study, collectively including 941 patients with CLL and confirmed COVID-19. Data from the beginning of the pandemic until March 16, 2021, were collected from 91 centers. The risk factors of case fatality rate (CFR), disease severity, and overall survival (OS) were investigated. OS analysis was restricted to patients with severe COVID-19 (definition: hospitalization with need of oxygen or admission into an intensive care unit). CFR in patients with severe COVID-19 was 38.4%. OS was inferior for patients in all treatment categories compared to untreated (p < 0.001). Untreated patients had a lower risk of death (HR = 0.54, 95% CI:0.41-0.72). The risk of death was higher for older patients and those suffering from cardiac failure (HR = 1.03, 95% CI:1.02-1.04; HR = 1.79, 95% CI:1.04-3.07, respectively). Age, CLL-directed treatment, and cardiac failure were significant risk factors of OS. Untreated patients had a better chance of survival than those on treatment or recently treated.

Published
2021

40. COVID-19 infection in adult patients with hematological malignancies: a European Hematology Association Survey (EPICOVIDEHA)

Author

Pagano, Livio, Salmanton-Garcia, Jon, Marchesi, Francesco, Busca, Alessandro, Corradini, Paolo, Hoenigl, Martin, Klimko, Nikolai, Koehler, Philipp, Pagliuca, Antonio, Passamonti, Francesco, Verga, Luisa, Visek, Benjamin, Ilhan, Osman, Nadali, Gianpaolo, Weinbergerova, Barbora, Cordoba-Mascunano, Raul, Marchetti, Monia, Collins, Graham P., Farina, Francesca, Cattaneo, Chiara, Cabirta, Alba, Gomes-Silva, Maria, Itri, Federico, van Doesum, Jaap, Ledoux, Marie-Pierre, Cernan, Martin, Jaksic, Ozren, Duarte, Rafael F., Magliano, Gabriele, Omrani, Ali S., Fracchiolla, Nicola S., Kulasekararaj, Austin, Valkovic, Toni, Poulsen, Christian Bjorn, Machado, Marina, Glenthoj, Andreas, Stoma, Igor, Racil, Zdenek, Piukovics, Klara, Navratil, Milan, Emarah, Ziad, Sili, Uluhan, Maertens, Johan, Blennow, Ola, Bergantim, Rui, Garcia-Vidal, Carolina, Prezioso, Lucia, Guidetti, Anna, del Principe, Maria Ilaria, Popova, Marina, de Jonge, Nick, Ormazabal-Velez, Irati, Fernandez, Noemi, Falces-Romero, Iker, Cuccaro, Annarosa, Meers, Stef, Buquicchio, Caterina, Antic, Darko, Al-Khabori, Murtadha, Garcia-Sanz, Ramon, Biernat, Monika M., Tisi, Maria Chiara, Sal, Ertan, Rahimli, Laman, Colovic, Natasa, Schonlein, Martin, Calbacho, Maria, Tascini, Carlo, Miranda-Castillo, Carolina, Khanna, Nina, Mendez, Gustavo-Adolfo, Petzer, Verena, Novak, Jan, Besson, Caroline, Dulery, Remy, Lamure, Sylvain, Nucci, Marcio, Zambrotta, Giovanni, Zak, Pavel, Seval, Guldane Cengiz, Bonuomo, Valentina, Mayer, Jiri, Lopez-Garcia, Alberto, Sacchi, Maria Vittoria, Booth, Stephen, Ciceri, Fabio, Oberti, Margherita, Salvini, Marco, Izuzquiza, Macarena, Nunes-Rodrigues, Raquel, Ammatuna, Emanuele, Obr, Ales, Herbrecht, Raoul, Nunez-Martin-Buitrago, Lucia, Mancini, Valentina, Shwaylia, Hawraa, Sciume, Mariarita, Essame, Jenna, Nygaard, Marietta, Batinic, Josip, Gonzaga, Yung, Regalado-Artamendi, Isabel, Karlsson, Linda Katharina, Shapetska, Maryia, Hanakova, Michaela, El-Ashwah, Shaimaa, Borbenyi, Zita, Colak, Gokce Melis, Nordlander, Anna, Dragonetti, Giulia, Maraglino, Alessio Maria Edoardo, Rinaldi, Amelia, De Ramon-Sanchez, Cristina, Cornely, Oliver A., Pagano, Livio, Salmanton-Garcia, Jon, Marchesi, Francesco, Busca, Alessandro, Corradini, Paolo, Hoenigl, Martin, Klimko, Nikolai, Koehler, Philipp, Pagliuca, Antonio, Passamonti, Francesco, Verga, Luisa, Visek, Benjamin, Ilhan, Osman, Nadali, Gianpaolo, Weinbergerova, Barbora, Cordoba-Mascunano, Raul, Marchetti, Monia, Collins, Graham P., Farina, Francesca, Cattaneo, Chiara, Cabirta, Alba, Gomes-Silva, Maria, Itri, Federico, van Doesum, Jaap, Ledoux, Marie-Pierre, Cernan, Martin, Jaksic, Ozren, Duarte, Rafael F., Magliano, Gabriele, Omrani, Ali S., Fracchiolla, Nicola S., Kulasekararaj, Austin, Valkovic, Toni, Poulsen, Christian Bjorn, Machado, Marina, Glenthoj, Andreas, Stoma, Igor, Racil, Zdenek, Piukovics, Klara, Navratil, Milan, Emarah, Ziad, Sili, Uluhan, Maertens, Johan, Blennow, Ola, Bergantim, Rui, Garcia-Vidal, Carolina, Prezioso, Lucia, Guidetti, Anna, del Principe, Maria Ilaria, Popova, Marina, de Jonge, Nick, Ormazabal-Velez, Irati, Fernandez, Noemi, Falces-Romero, Iker, Cuccaro, Annarosa, Meers, Stef, Buquicchio, Caterina, Antic, Darko, Al-Khabori, Murtadha, Garcia-Sanz, Ramon, Biernat, Monika M., Tisi, Maria Chiara, Sal, Ertan, Rahimli, Laman, Colovic, Natasa, Schonlein, Martin, Calbacho, Maria, Tascini, Carlo, Miranda-Castillo, Carolina, Khanna, Nina, Mendez, Gustavo-Adolfo, Petzer, Verena, Novak, Jan, Besson, Caroline, Dulery, Remy, Lamure, Sylvain, Nucci, Marcio, Zambrotta, Giovanni, Zak, Pavel, Seval, Guldane Cengiz, Bonuomo, Valentina, Mayer, Jiri, Lopez-Garcia, Alberto, Sacchi, Maria Vittoria, Booth, Stephen, Ciceri, Fabio, Oberti, Margherita, Salvini, Marco, Izuzquiza, Macarena, Nunes-Rodrigues, Raquel, Ammatuna, Emanuele, Obr, Ales, Herbrecht, Raoul, Nunez-Martin-Buitrago, Lucia, Mancini, Valentina, Shwaylia, Hawraa, Sciume, Mariarita, Essame, Jenna, Nygaard, Marietta, Batinic, Josip, Gonzaga, Yung, Regalado-Artamendi, Isabel, Karlsson, Linda Katharina, Shapetska, Maryia, Hanakova, Michaela, El-Ashwah, Shaimaa, Borbenyi, Zita, Colak, Gokce Melis, Nordlander, Anna, Dragonetti, Giulia, Maraglino, Alessio Maria Edoardo, Rinaldi, Amelia, De Ramon-Sanchez, Cristina, and Cornely, Oliver A.

Abstract

Background Patients with hematological malignancies (HM) are at high risk of mortality from SARS-CoV-2 disease 2019 (COVID-19). A better understanding of risk factors for adverse outcomes may improve clinical management in these patients. We therefore studied baseline characteristics of HM patients developing COVID-19 and analyzed predictors of mortality. Methods The survey was supported by the Scientific Working Group Infection in Hematology of the European Hematology Association (EHA). Eligible for the analysis were adult patients with HM and laboratory-confirmed COVID-19 observed between March and December 2020. Results The study sample includes 3801 cases, represented by lymphoproliferative (mainly non-Hodgkin lymphoma n = 1084, myeloma n = 684 and chronic lymphoid leukemia n = 474) and myeloproliferative malignancies (mainly acute myeloid leukemia n = 497 and myelodysplastic syndromes n = 279). Severe/critical COVID-19 was observed in 63.8% of patients (n = 2425). Overall, 2778 (73.1%) of the patients were hospitalized, 689 (18.1%) of whom were admitted to intensive care units (ICUs). Overall, 1185 patients (31.2%) died. The primary cause of death was COVID-19 in 688 patients (58.1%), HM in 173 patients (14.6%), and a combination of both COVID-19 and progressing HM in 155 patients (13.1%). Highest mortality was observed in acute myeloid leukemia (199/497, 40%) and myelodysplastic syndromes (118/279, 42.3%). The mortality rate significantly decreased between the first COVID-19 wave (March-May 2020) and the second wave (October-December 2020) (581/1427, 40.7% vs. 439/1773, 24.8%, p value < 0.0001). In the multivariable analysis, age, active malignancy, chronic cardiac disease, liver disease, renal impairment, smoking history, and ICU stay correlated with mortality. Acute myeloid leukemia was a higher mortality risk than lymphoproliferative diseases. Conclusions This survey confirms that COVID-19 patients with HM are at high risk of lethal complications. However

Published
2021

41. Advances in the laboratory diagnosis of hereditary spherocytosis

Author

Gulbis, Béatrice, Corraza, Francis, De Wilde, Virginie, Wittnebel, Sebastian, Zouaoui Boudjeltia, Karim, Labarque, Veerle, Glenthoj, Andreas, Lazarova, Elena, Gulbis, Béatrice, Corraza, Francis, De Wilde, Virginie, Wittnebel, Sebastian, Zouaoui Boudjeltia, Karim, Labarque, Veerle, Glenthoj, Andreas, and Lazarova, Elena

Abstract

Establishing the diagnosis in a patient with hereditary hemolytic anemia is a complex and laborious procedure that involves a comprehensive evaluation of clinical and laboratory features. Because the group of associated pathologies is very heterogeneous with regard to underlying cause, disease severity, age of onset and clinical course, ascertaining the correct diagnosis can be challenging. Thereby, even cases of typical clinical and biological presentation of hereditary spherocytosis (HS), the main cause of hereditary hemolytic anemia in Northern Europe, need confirmation by specialized screening and diagnostic tests. Unfortunately, with reported sensitivities of 53%-95%, none of those tests alone is able to identify all cases of HS, in particular, mild and moderate forms of HS, and the use of at least two screening tests was suggested. Therefore, the general objective of this research was to investigate and introduce into clinical practice new screening and diagnostic tools for hereditary spherocytosis, in order to improve the laboratory diagnostic algorithm. Based on the pathophysiology of HS, it has been hypothesized that automated reticulocyte parameters could be of great interest as screening tests especially if able to demonstrate the presence of small dehydrated reticulocytes coexistent with spherocytes. Thereby, we were first interested in investigating the new automated reticulocyte parameters as a screening tool for HS. We analyzed the diagnostic performances of these parameters, estimated their efficiency in differentiating HS from other conditions that affect erythropoiesis, and introduced them into a new screening algorithm for HS as a highly efficient first line test. Secondly, we were interested in the osmotic gradient ektacytometry, a diagnostic tool for HS and other membrane pathologies, already known for several decades. However, this method remained with very limited use only in highly specialized laboratories because of the complexity of the equ, Doctorat en Sciences médicales (Médecine), info:eu-repo/semantics/nonPublished

Published
2021

49. ERN-EuroBloodNet European Registry of Patients Affected by Red Blood Cell Disorders and COVID-19

Author

Velasco, Pablo, Longo, Filomena, Piolatto, Andrea, Bardón-Cancho, Eduardo J., Ponce-Salas, Beatriz, Flevari, Pagona, Voskaridou, Ersi, Biemond, Bart J., Nur, Erfan, Delaporta, Polyxeni, Besse-Hammer, Tatiana, Ruiz-Llobet, Anna, Raso, Simona, Spasiano, Anna, Guerzoni, Maria Elena, Beneitez-Pastor, David, Dedeken, Laurence, Pepe, Alessia, Rosso, Rosamaria, Kunz, Joachim B., de Montalembert, Mariane, Campisi, Saveria, Glenthøj, Andreas, Gonzalez Urdiales, Paula, Benghiat, Fleur Samantha, Azerad, Marie-Agnès, Saunders, Christopher J., Ferreira Faria, Teresa, Casini, Tommaso, Bagnato, Sabrina, Van de Velde, Ann, Labarque, Veerle, Bertoni, Elisa, Van Damme, An, Diamantidis, Michael D., Russo, Roberta, Stiakaki, Eftichia, Quota, Alessandra, Christou, Soteroula, Teles, Maria Jose, Lafiatis, Ioannis, Kerkhoffs, Jean-Louis, Argüello Marina, María, Lorite, Mikael, Rodriguez, Alexis, Iolascon, Achille, Taher, Ali T., Colombatti, Raffaella, Roy, Noemi, and Mañú Pereira, Maria Del Mar

Published
2021
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