1. Interactive calculator to estimate insulin sensitivity in type 1 diabetes
- Author
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Andrzej S Januszewski, Pawel Niedzwiecki, Nirupa Sachithanandan, Glenn M Ward, David N O’Neal, Dorota A Zozulinska‐Ziolkiewicz, Aleksandra A Uruska, and Alicia J Jenkins
- Subjects
Insulin sensitivity ,Online calculator ,Type 1 diabetes ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
ABSTRACT The gold standard for measuring insulin sensitivity (IS) is the hyperinsulinemic–euglycemic clamp, a time, costly, and labor‐intensive research tool. A low insulin sensitivity is associated with a complication‐risk in type 1 diabetes. Various formulae using clinical data have been developed and correlated with measured IS in type 1 diabetes. We consolidated multiple formulae into an online calculator (bit.ly/estimated‐GDR), enabling comparison of IS and its probability of IS 6.50 mg/kg/min (high), as measured in a validation set of clamps in 104 adults with type 1 diabetes. Insulin sensitivity calculations using different formulae varied significantly, with correlations (R2) ranging 0.005–0.87 with agreement in detecting low and high glucose disposal rates in the range 49–93% and 89–100%, respectively. We demonstrate that although the calculated IS varies between formulae, their interpretation remains consistent. Our free online calculator offers a user‐friendly tool for individual IS calculations and also offers efficient batch processing of data for research.
- Published
- 2024
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