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6 results on '"Glaus, Lukas"'

1. Development of a Translational Autologous Microthrombi-Induced MINOCA Pig Model

Author

Cesarovic, Nikola, primary, Weisskopf, Miriam, additional, Stolte, Thorald, additional, Trimmel, Nina, additional, Hierweger, Melanie M., additional, Hoh, Tobias, additional, Iske, Jasper, additional, Waschkies, Conny, additional, Chen, Jia Lu, additional, van Gelder, Eva, additional, Leuthardt, Andrea, additional, Glaus, Lukas, additional, Rösch, Yannick, additional, Stoeck, Christian T., additional, Wolint, Petra, additional, Obrist, Dominik, additional, Kozerke, Sebastian, additional, Falk, Volkmar, additional, and Emmert, Maximilian Y., additional

Published
2023
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2. Development of a Translational Autologous Microthrombi-Induced MINOCA Pig Model

Author

Cesarovic, Nikola, Weisskopf, Miriam, Stolte, Thorald, Trimmel, Nina, Hierweger, Melanie M, Hoh, Tobias, Iske, Jasper, Waschkies, Conny, Chen, Jia Lu, van Gelder, Eva, Leuthardt, Andrea, Glaus, Lukas, Rösch, Yannick, Stoeck, Christian T, Wolint, Petra, Obrist, Dominik, Kozerke, Sebastian, Falk, Volkmar, and Emmert, Maximilian Y

Subjects
570 Life sciences, biology, 610 Medicine & health
Published
2023
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3. Dos and don'ts in large animal models of aortic insufficiency

Author

Weisskopf, Miriam, primary, Glaus, Lukas, additional, Trimmel, Nina E., additional, Hierweger, Melanie M., additional, Leuthardt, Andrea S., additional, Kukucka, Marian, additional, Stolte, Thorald, additional, Stoeck, Christian T., additional, Falk, Volkmar, additional, Emmert, Maximilian Y., additional, Kofler, Markus, additional, and Cesarovic, Nikola, additional

Published
2022
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5. Septaly Oriented Mild Aortic Regurgitant Jets Negatively Influence Left Ventricular Blood Flow—Insights From 4D Flow MRI Animal Study

Author

Cesarovic, Nikola, Weisskopf, Miriam, Kron, Mareike, Glaus, Lukas, Peper, Eva S, Buoso, Stefano, Suendermann, Simon, Canic, Marko, Falk, Volkmar, Kozerke, Sebastian, Emmert, Maximilian Y, Stoeck, Christian T, and University of Zurich

Subjects
4D flow MRI, intraventricular hemodynamics, vortex formation, paravalvular leakage, aortic regurgitation, mild regurgitation, translational large animal model, 610 Medicine & health, 11359 Institute for Regenerative Medicine (IREM), Cardiovascular Medicine, cardiovascular system, Cardiology and Cardiovascular Medicine, Original Research
Abstract

Objectives: Paravalvular leakage (PVL) and eccentric aortic regurgitation remain a major clinical concern in patients receiving transcatheter aortic valve replacement (TAVR), and regurgitant volume remains the main readout parameter in clinical assessment. In this work we investigate the effect of jet origin and trajectory of mild aortic regurgitation on left ventricular hemodynamics in a porcine model. Methods: A pig model of mild aortic regurgitation/PVL was established by transcatheter piercing and dilating the non-coronary (NCC) or right coronary cusp (RCC) of the aortic valve close to the valve annulus. The interaction between regurgitant blood and LV hemodynamics was assessed by 4D flow cardiovascular MRI. Results: Six RCC, six NCC, and two control animals were included in the study and with one dropout in the NCC group, the success rate of model creation was 93%. Regurgitant jets originating from NCC were directed along the ventricular side of the anterior mitral leaflet and integrated well into the diastolic vortex forming in the left ventricular outflow tract. However, jets from the RCC were orientated along the septum colliding with flow within the vortex, and progressing down to the apex. As a consequence, the presence as well as the area of the vortex was reduced at the site of impact compared to the NCC group. Impairment of vortex formation was localized to the area of impact and not the entire vortex ring. Blood from the NCC jet was largely ejected during the following systole, whereas ejection of large portion of RCC blood was protracted. Conclusions: Even for mild regurgitation, origin and trajectory of the regurgitant jet does cause a different effect on LV hemodynamics. Septaly oriented jets originating from RCC collide with the diastolic vortex, reduce its size, and reach the apical region of the left ventricle where blood resides extendedly. Hence, RCC jets display hemodynamic features which may have a potential negative impact on the long-term burden to the heart., Frontiers in Cardiovascular Medicine, 8, ISSN:2297-055X

Published
2021

6. Septaly Oriented Mild Aortic Regurgitant Jets Negatively Influence Left Ventricular Blood Flow—Insights From 4D Flow MRI Animal Study

Author

Cesarovic, Nikola; https://orcid.org/0000-0001-6744-2928, Weisskopf, Miriam; https://orcid.org/0000-0001-6012-3051, Kron, Mareike, Glaus, Lukas, Peper, Eva S, Buoso, Stefano; https://orcid.org/0000-0002-1293-3225, Suendermann, Simon, Canic, Marko, Falk, Volkmar; https://orcid.org/0000-0002-7911-8620, Kozerke, Sebastian; https://orcid.org/0000-0003-3725-8884, Emmert, Maximilian Y; https://orcid.org/0000-0002-8837-1716, Stoeck, Christian T; https://orcid.org/0000-0001-8670-0929, Cesarovic, Nikola; https://orcid.org/0000-0001-6744-2928, Weisskopf, Miriam; https://orcid.org/0000-0001-6012-3051, Kron, Mareike, Glaus, Lukas, Peper, Eva S, Buoso, Stefano; https://orcid.org/0000-0002-1293-3225, Suendermann, Simon, Canic, Marko, Falk, Volkmar; https://orcid.org/0000-0002-7911-8620, Kozerke, Sebastian; https://orcid.org/0000-0003-3725-8884, Emmert, Maximilian Y; https://orcid.org/0000-0002-8837-1716, and Stoeck, Christian T; https://orcid.org/0000-0001-8670-0929

Abstract

Objectives: Paravalvular leakage (PVL) and eccentric aortic regurgitation remain a major clinical concern in patients receiving transcatheter aortic valve replacement (TAVR), and regurgitant volume remains the main readout parameter in clinical assessment. In this work we investigate the effect of jet origin and trajectory of mild aortic regurgitation on left ventricular hemodynamics in a porcine model. Methods: A pig model of mild aortic regurgitation/PVL was established by transcatheter piercing and dilating the non-coronary (NCC) or right coronary cusp (RCC) of the aortic valve close to the valve annulus. The interaction between regurgitant blood and LV hemodynamics was assessed by 4D flow cardiovascular MRI. Results: Six RCC, six NCC, and two control animals were included in the study and with one dropout in the NCC group, the success rate of model creation was 93%. Regurgitant jets originating from NCC were directed along the ventricular side of the anterior mitral leaflet and integrated well into the diastolic vortex forming in the left ventricular outflow tract. However, jets from the RCC were orientated along the septum colliding with flow within the vortex, and progressing down to the apex. As a consequence, the presence as well as the area of the vortex was reduced at the site of impact compared to the NCC group. Impairment of vortex formation was localized to the area of impact and not the entire vortex ring. Blood from the NCC jet was largely ejected during the following systole, whereas ejection of large portion of RCC blood was protracted. Conclusions: Even for mild regurgitation, origin and trajectory of the regurgitant jet does cause a different effect on LV hemodynamics. Septaly oriented jets originating from RCC collide with the diastolic vortex, reduce its size, and reach the apical region of the left ventricle where blood resides extendedly. Hence, RCC jets display hemodynamic features which may have a potential negative impact on the long-term b

Published
2021

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