1. Epstein-Barr Virus Keratouveitis-Induced Malignant Glaucoma After Penetrating Keratoplasty: A Case Report and Literature Review.
- Author
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Chuckpaiwong V, Phimpho P, Lekhanont K, Kaewkorn P, and Jongkhajornpong P
- Subjects
- Humans, Female, Aged, Ganciclovir therapeutic use, Aqueous Humor virology, Valacyclovir therapeutic use, Keratitis virology, Keratitis diagnosis, Keratitis etiology, Keratitis drug therapy, Endothelium, Corneal virology, Endothelium, Corneal pathology, Glaucoma etiology, Glaucoma virology, Glaucoma diagnosis, Glaucoma surgery, Polymerase Chain Reaction, Keratoplasty, Penetrating adverse effects, Eye Infections, Viral diagnosis, Eye Infections, Viral virology, Eye Infections, Viral etiology, Eye Infections, Viral drug therapy, Epstein-Barr Virus Infections diagnosis, Epstein-Barr Virus Infections complications, Epstein-Barr Virus Infections virology, Uveitis, Anterior virology, Uveitis, Anterior diagnosis, Uveitis, Anterior etiology, Uveitis, Anterior drug therapy, Herpesvirus 4, Human genetics, Intraocular Pressure, Antiviral Agents therapeutic use, DNA, Viral analysis
- Abstract
Purpose: To report a case of Epstein-Barr virus (EBV) keratouveitis-induced malignant glaucoma after repeat penetrating keratoplasty (PK)., Methods: Retrospective review of the patient's medical records and review of literature on EBV corneal endotheliitis and/or anterior uveitis., Results: A 78-year-old Thai female patient presented with a markedly edematous corneal graft, dense pigmented keratic precipitates, fibrinous anterior chamber reaction, uniformly flat anterior chamber, and ocular hypertension of 55 mmHg in the left eye on the first day after the third PK. An aqueous tap for polymerase chain reaction analysis was positive for EBV DNA but negative for other herpesviruses. The patient was diagnosed with EBV endotheliitis and anterior uveitis-induced malignant glaucoma; and successfully treated with oral valacyclovir and topical 2% ganciclovir eye drops., Conclusions: EBV endotheliitis and anterior uveitis can induce malignant glaucoma following PK. A high index of suspicion is required when a patient has a history of unexplained multiple graft rejections.
- Published
- 2024
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