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1. Data from Threshold Analysis and Biodistribution of Fluorescently Labeled Bevacizumab in Human Breast Cancer

Author

Koch, Maximilian, primary, de Jong, Johannes S., primary, Glatz, Jürgen, primary, Symvoulidis, Panagiotis, primary, Lamberts, Laetitia E., primary, Adams, Arthur L.L., primary, Kranendonk, Mariëtte E.G., primary, Terwisscha van Scheltinga, Anton G.T., primary, Aichler, Michaela, primary, Jansen, Liesbeth, primary, de Vries, Jakob, primary, Lub-de Hooge, Marjolijn N., primary, Schröder, Carolien P., primary, Jorritsma-Smit, Annelies, primary, Linssen, Matthijs D., primary, de Boer, Esther, primary, van der Vegt, Bert, primary, Nagengast, Wouter B., primary, Elias, Sjoerd G., primary, Oliveira, Sabrina, primary, Witkamp, Arjen J., primary, Mali, Willem P.T.M., primary, Van der Wall, Elsken, primary, Garcia-Allende, P. Beatriz, primary, van Diest, Paul J., primary, de Vries, Elisabeth G.E., primary, Walch, Axel, primary, van Dam, Gooitzen M., primary, and Ntziachristos, Vasilis, primary

Published
2023
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2. Supplementary Figure 1 from Tumor-Specific Uptake of Fluorescent Bevacizumab–IRDye800CW Microdosing in Patients with Primary Breast Cancer: A Phase I Feasibility Study

Author

Lamberts, Laetitia E., primary, Koch, Maximillian, primary, de Jong, Johannes S., primary, Adams, Arthur L.L., primary, Glatz, Jürgen, primary, Kranendonk, Mariëtte E.G., primary, Terwisscha van Scheltinga, Anton G.T., primary, Jansen, Liesbeth, primary, de Vries, Jakob, primary, Lub-de Hooge, Marjolijn N., primary, Schröder, Carolien P., primary, Jorritsma-Smit, Annelies, primary, Linssen, Matthijs D., primary, de Boer, Esther, primary, van der Vegt, Bert, primary, Nagengast, Wouter B., primary, Elias, Sjoerd G., primary, Oliveira, Sabrina, primary, Witkamp, Arjen J., primary, Mali, Willem P.Th.M., primary, Van der Wall, Elsken, primary, van Diest, Paul J., primary, de Vries, Elisabeth G.E., primary, Ntziachristos, Vasilis, primary, and van Dam, Gooitzen M., primary

Published
2023
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3. Supplementary Figure 7 from Tumor-Specific Uptake of Fluorescent Bevacizumab–IRDye800CW Microdosing in Patients with Primary Breast Cancer: A Phase I Feasibility Study

Author

Lamberts, Laetitia E., primary, Koch, Maximillian, primary, de Jong, Johannes S., primary, Adams, Arthur L.L., primary, Glatz, Jürgen, primary, Kranendonk, Mariëtte E.G., primary, Terwisscha van Scheltinga, Anton G.T., primary, Jansen, Liesbeth, primary, de Vries, Jakob, primary, Lub-de Hooge, Marjolijn N., primary, Schröder, Carolien P., primary, Jorritsma-Smit, Annelies, primary, Linssen, Matthijs D., primary, de Boer, Esther, primary, van der Vegt, Bert, primary, Nagengast, Wouter B., primary, Elias, Sjoerd G., primary, Oliveira, Sabrina, primary, Witkamp, Arjen J., primary, Mali, Willem P.Th.M., primary, Van der Wall, Elsken, primary, van Diest, Paul J., primary, de Vries, Elisabeth G.E., primary, Ntziachristos, Vasilis, primary, and van Dam, Gooitzen M., primary

Published
2023
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4. Supplementary Figure 6 from Tumor-Specific Uptake of Fluorescent Bevacizumab–IRDye800CW Microdosing in Patients with Primary Breast Cancer: A Phase I Feasibility Study

Author

Lamberts, Laetitia E., primary, Koch, Maximillian, primary, de Jong, Johannes S., primary, Adams, Arthur L.L., primary, Glatz, Jürgen, primary, Kranendonk, Mariëtte E.G., primary, Terwisscha van Scheltinga, Anton G.T., primary, Jansen, Liesbeth, primary, de Vries, Jakob, primary, Lub-de Hooge, Marjolijn N., primary, Schröder, Carolien P., primary, Jorritsma-Smit, Annelies, primary, Linssen, Matthijs D., primary, de Boer, Esther, primary, van der Vegt, Bert, primary, Nagengast, Wouter B., primary, Elias, Sjoerd G., primary, Oliveira, Sabrina, primary, Witkamp, Arjen J., primary, Mali, Willem P.Th.M., primary, Van der Wall, Elsken, primary, van Diest, Paul J., primary, de Vries, Elisabeth G.E., primary, Ntziachristos, Vasilis, primary, and van Dam, Gooitzen M., primary

Published
2023
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5. Supplemental Movie S1. Explanatory Movie of Multiplex Advanced Pathology Imaging (MAPI). from Tumor-Specific Uptake of Fluorescent Bevacizumab–IRDye800CW Microdosing in Patients with Primary Breast Cancer: A Phase I Feasibility Study

Author

Lamberts, Laetitia E., primary, Koch, Maximillian, primary, de Jong, Johannes S., primary, Adams, Arthur L.L., primary, Glatz, Jürgen, primary, Kranendonk, Mariëtte E.G., primary, Terwisscha van Scheltinga, Anton G.T., primary, Jansen, Liesbeth, primary, de Vries, Jakob, primary, Lub-de Hooge, Marjolijn N., primary, Schröder, Carolien P., primary, Jorritsma-Smit, Annelies, primary, Linssen, Matthijs D., primary, de Boer, Esther, primary, van der Vegt, Bert, primary, Nagengast, Wouter B., primary, Elias, Sjoerd G., primary, Oliveira, Sabrina, primary, Witkamp, Arjen J., primary, Mali, Willem P.Th.M., primary, Van der Wall, Elsken, primary, van Diest, Paul J., primary, de Vries, Elisabeth G.E., primary, Ntziachristos, Vasilis, primary, and van Dam, Gooitzen M., primary

Published
2023
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6. Supplementary Figure 4 from Tumor-Specific Uptake of Fluorescent Bevacizumab–IRDye800CW Microdosing in Patients with Primary Breast Cancer: A Phase I Feasibility Study

Author

Lamberts, Laetitia E., primary, Koch, Maximillian, primary, de Jong, Johannes S., primary, Adams, Arthur L.L., primary, Glatz, Jürgen, primary, Kranendonk, Mariëtte E.G., primary, Terwisscha van Scheltinga, Anton G.T., primary, Jansen, Liesbeth, primary, de Vries, Jakob, primary, Lub-de Hooge, Marjolijn N., primary, Schröder, Carolien P., primary, Jorritsma-Smit, Annelies, primary, Linssen, Matthijs D., primary, de Boer, Esther, primary, van der Vegt, Bert, primary, Nagengast, Wouter B., primary, Elias, Sjoerd G., primary, Oliveira, Sabrina, primary, Witkamp, Arjen J., primary, Mali, Willem P.Th.M., primary, Van der Wall, Elsken, primary, van Diest, Paul J., primary, de Vries, Elisabeth G.E., primary, Ntziachristos, Vasilis, primary, and van Dam, Gooitzen M., primary

Published
2023
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7. Supplementary Figure 5 from Tumor-Specific Uptake of Fluorescent Bevacizumab–IRDye800CW Microdosing in Patients with Primary Breast Cancer: A Phase I Feasibility Study

Author

Lamberts, Laetitia E., primary, Koch, Maximillian, primary, de Jong, Johannes S., primary, Adams, Arthur L.L., primary, Glatz, Jürgen, primary, Kranendonk, Mariëtte E.G., primary, Terwisscha van Scheltinga, Anton G.T., primary, Jansen, Liesbeth, primary, de Vries, Jakob, primary, Lub-de Hooge, Marjolijn N., primary, Schröder, Carolien P., primary, Jorritsma-Smit, Annelies, primary, Linssen, Matthijs D., primary, de Boer, Esther, primary, van der Vegt, Bert, primary, Nagengast, Wouter B., primary, Elias, Sjoerd G., primary, Oliveira, Sabrina, primary, Witkamp, Arjen J., primary, Mali, Willem P.Th.M., primary, Van der Wall, Elsken, primary, van Diest, Paul J., primary, de Vries, Elisabeth G.E., primary, Ntziachristos, Vasilis, primary, and van Dam, Gooitzen M., primary

Published
2023
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8. Supplemental Materials and Methods and Supplementary Figures 1 and 2 from Threshold Analysis and Biodistribution of Fluorescently Labeled Bevacizumab in Human Breast Cancer

Author

Koch, Maximilian, primary, de Jong, Johannes S., primary, Glatz, Jürgen, primary, Symvoulidis, Panagiotis, primary, Lamberts, Laetitia E., primary, Adams, Arthur L.L., primary, Kranendonk, Mariëtte E.G., primary, Terwisscha van Scheltinga, Anton G.T., primary, Aichler, Michaela, primary, Jansen, Liesbeth, primary, de Vries, Jakob, primary, Lub-de Hooge, Marjolijn N., primary, Schröder, Carolien P., primary, Jorritsma-Smit, Annelies, primary, Linssen, Matthijs D., primary, de Boer, Esther, primary, van der Vegt, Bert, primary, Nagengast, Wouter B., primary, Elias, Sjoerd G., primary, Oliveira, Sabrina, primary, Witkamp, Arjen J., primary, Mali, Willem P.T.M., primary, Van der Wall, Elsken, primary, Garcia-Allende, P. Beatriz, primary, van Diest, Paul J., primary, de Vries, Elisabeth G.E., primary, Walch, Axel, primary, van Dam, Gooitzen M., primary, and Ntziachristos, Vasilis, primary

Published
2023
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9. Supplementary Figure 3 from Tumor-Specific Uptake of Fluorescent Bevacizumab–IRDye800CW Microdosing in Patients with Primary Breast Cancer: A Phase I Feasibility Study

Author

Lamberts, Laetitia E., primary, Koch, Maximillian, primary, de Jong, Johannes S., primary, Adams, Arthur L.L., primary, Glatz, Jürgen, primary, Kranendonk, Mariëtte E.G., primary, Terwisscha van Scheltinga, Anton G.T., primary, Jansen, Liesbeth, primary, de Vries, Jakob, primary, Lub-de Hooge, Marjolijn N., primary, Schröder, Carolien P., primary, Jorritsma-Smit, Annelies, primary, Linssen, Matthijs D., primary, de Boer, Esther, primary, van der Vegt, Bert, primary, Nagengast, Wouter B., primary, Elias, Sjoerd G., primary, Oliveira, Sabrina, primary, Witkamp, Arjen J., primary, Mali, Willem P.Th.M., primary, Van der Wall, Elsken, primary, van Diest, Paul J., primary, de Vries, Elisabeth G.E., primary, Ntziachristos, Vasilis, primary, and van Dam, Gooitzen M., primary

Published
2023
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10. Supplementary Figure 2 from Tumor-Specific Uptake of Fluorescent Bevacizumab–IRDye800CW Microdosing in Patients with Primary Breast Cancer: A Phase I Feasibility Study

Author

Lamberts, Laetitia E., primary, Koch, Maximillian, primary, de Jong, Johannes S., primary, Adams, Arthur L.L., primary, Glatz, Jürgen, primary, Kranendonk, Mariëtte E.G., primary, Terwisscha van Scheltinga, Anton G.T., primary, Jansen, Liesbeth, primary, de Vries, Jakob, primary, Lub-de Hooge, Marjolijn N., primary, Schröder, Carolien P., primary, Jorritsma-Smit, Annelies, primary, Linssen, Matthijs D., primary, de Boer, Esther, primary, van der Vegt, Bert, primary, Nagengast, Wouter B., primary, Elias, Sjoerd G., primary, Oliveira, Sabrina, primary, Witkamp, Arjen J., primary, Mali, Willem P.Th.M., primary, Van der Wall, Elsken, primary, van Diest, Paul J., primary, de Vries, Elisabeth G.E., primary, Ntziachristos, Vasilis, primary, and van Dam, Gooitzen M., primary

Published
2023
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11. Supplemental Material and Methods from Tumor-Specific Uptake of Fluorescent Bevacizumab–IRDye800CW Microdosing in Patients with Primary Breast Cancer: A Phase I Feasibility Study

Author

Lamberts, Laetitia E., primary, Koch, Maximillian, primary, de Jong, Johannes S., primary, Adams, Arthur L.L., primary, Glatz, Jürgen, primary, Kranendonk, Mariëtte E.G., primary, Terwisscha van Scheltinga, Anton G.T., primary, Jansen, Liesbeth, primary, de Vries, Jakob, primary, Lub-de Hooge, Marjolijn N., primary, Schröder, Carolien P., primary, Jorritsma-Smit, Annelies, primary, Linssen, Matthijs D., primary, de Boer, Esther, primary, van der Vegt, Bert, primary, Nagengast, Wouter B., primary, Elias, Sjoerd G., primary, Oliveira, Sabrina, primary, Witkamp, Arjen J., primary, Mali, Willem P.Th.M., primary, Van der Wall, Elsken, primary, van Diest, Paul J., primary, de Vries, Elisabeth G.E., primary, Ntziachristos, Vasilis, primary, and van Dam, Gooitzen M., primary

Published
2023
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14. Threshold Analysis and Biodistribution of Fluorescently Labeled Bevacizumab in Human Breast Cancer

Author

Koch, Maximillian, de Jong, Johannes S, Glatz, Jürgen, Symvoulidis, Panagiotis, Lamberts, Laetitia E, Adams, Arthur, Kranendonk, Mariëtte E G, Terwisscha van Scheltinga, Anton G T, Aichler, Michaela, Jansen, Liesbeth, de Vries, Jakob, Lub-de Hooge, Marjolijn N, Schröder, Carolina P, Jorritsma-Smit, Annelies, Linssen, Matthijs D, de Boer, Esther, van der Vegt, Bert, Nagengast, Wouter B, Elias, Sjoerd G, Oliveira, Sabrina, Witkamp, Arjen, Mali, Willem P Th M, van der Wall, Elsken, Garcia-Allende, Beatriz P, Van Diest, Paul J, de Vries, Elisabeth G, Walch, Axel, van Dam, Gooitzen M, Ntziachristos, Vasilis, Celbiologie, Sub Cell Biology, Pharmaceutics, Celbiologie, Sub Cell Biology, Pharmaceutics, Guided Treatment in Optimal Selected Cancer Patients (GUTS), Microbes in Health and Disease (MHD), ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), and Damage and Repair in Cancer Development and Cancer Treatment (DARE)

Subjects
0301 basic medicine, Cancer Research, Pathology, medicine.medical_specialty, Fluorescence-lifetime imaging microscopy, Biodistribution, Indoles, Bevacizumab, SURGERY, INDOCYANINE GREEN, Antineoplastic Agents, Breast Neoplasms, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, In vivo, Image Interpretation, Computer-Assisted, Taverne, Journal Article, Medicine, Humans, HEAD, MARGINS, Aged, Fluorescent Dyes, AGENT, business.industry, Benzenesulfonates, Optical Imaging, Cancer, Histology, Middle Aged, medicine.disease, Molecular Imaging, 030104 developmental biology, Oncology, chemistry, 030220 oncology & carcinogenesis, SAFETY, Female, Molecular imaging, business, Indocyanine green, medicine.drug, FOLATE
Abstract

In vivo tumor labeling with fluorescent agents may assist endoscopic and surgical guidance for cancer therapy as well as create opportunities to directly observe cancer biology in patients. However, malignant and nonmalignant tissues are usually distinguished on fluorescence images by applying empirically determined fluorescence intensity thresholds. Here, we report the development of fSTREAM, a set of analytic methods designed to streamline the analysis of surgically excised breast tissues by collecting and statistically processing hybrid multiscale fluorescence, color, and histology readouts toward precision fluorescence imaging. fSTREAM addresses core questions of how to relate fluorescence intensity to tumor tissue and how to quantitatively assign a normalized threshold that sufficiently differentiates tumor tissue from healthy tissue. Using fSTREAM we assessed human breast tumors stained in vivo with fluorescent bevacizumab at microdose levels. Showing that detection of such levels is achievable, we validated fSTREAM for high-resolution mapping of the spatial pattern of labeled antibody and its relation to the underlying cancer pathophysiology and tumor border on a per patient basis. We demonstrated a 98% sensitivity and 79% specificity when using labeled bevacizumab to outline the tumor mass. Overall, our results illustrate a quantitative approach to relate fluorescence signals to malignant tissues and improve the theranostic application of fluorescence molecular imaging. Cancer Res; 77(3); 623–31. ©2016 AACR.

Published
2017

16. Fluorescently labeled bevacizumab in human breast cancer: defining the classification threshold

Author

Koch, Maximilian, additional, de Jong, Johannes S., additional, Glatz, Jürgen, additional, Symvoulidis, Panagiotis, additional, Lamberts, Laetitia E., additional, Adams, Arthur L. L., additional, Kranendonk, Mariëtte E. G., additional, Terwisscha van Scheltinga, Anton G. T., additional, Aichler, Michaela, additional, Jansen, Liesbeth, additional, de Vries, Jakob, additional, Lub-de Hooge, Marjolijn N., additional, Schröder, Carolien P., additional, Jorritsma-Smit, Annelies, additional, Linssen, Matthijs D., additional, de Boer, Esther, additional, van der Vegt, Bert, additional, Nagengast, Wouter B., additional, Elias, Sjoerd G., additional, Oliveira, Sabrina, additional, Witkamp, Arjen J., additional, Mali, Willem P. Th. M., additional, Van der Wall, Elsken, additional, Garcia-Allende, P. Beatriz, additional, van Diest, Paul J., additional, de Vries, Elisabeth G. E., additional, Walch, Axel, additional, van Dam, Gooitzen M., additional, and Ntziachristos, Vasilis, additional

Published
2017
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17. Tumor-Specific Uptake of Fluorescent Bevacizumab–IRDye800CW Microdosing in Patients with Primary Breast Cancer: A Phase I Feasibility Study

Author

Lamberts, Laetitia E., primary, Koch, Maximillian, additional, de Jong, Johannes S., additional, Adams, Arthur L.L., additional, Glatz, Jürgen, additional, Kranendonk, Mariëtte E.G., additional, Terwisscha van Scheltinga, Anton G.T., additional, Jansen, Liesbeth, additional, de Vries, Jakob, additional, Lub-de Hooge, Marjolijn N., additional, Schröder, Carolien P., additional, Jorritsma-Smit, Annelies, additional, Linssen, Matthijs D., additional, de Boer, Esther, additional, van der Vegt, Bert, additional, Nagengast, Wouter B., additional, Elias, Sjoerd G., additional, Oliveira, Sabrina, additional, Witkamp, Arjen J., additional, Mali, Willem P.Th.M., additional, Van der Wall, Elsken, additional, van Diest, Paul J., additional, de Vries, Elisabeth G.E., additional, Ntziachristos, Vasilis, additional, and van Dam, Gooitzen M., additional

Published
2017
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18. Real-time intra-operative and endoscopic molecular fluorescence imaging

Author

Glatz, Jürgen, Ntziachristos, Vasilis (Prof. Dr.), Kleinsteuber, Martin (Prof. Dr.), and Ziegler, Sibylle (Prof. Dr.)

Subjects
Ingenieurwissenschaften, ddc:620
Abstract

A camera system for improved tumor detection during surgical or endoscopic procedures was developed and evaluated in clinical practice. By using optical imaging in conjunction with targeted fluorescent contrast agents molecular structures of malign cells could be visualized. Together with new algorithms for the multispectral acquisition and correction of fluorescence images in biological tissue, the developed system can decisively improve cancer diagnosis and therapy. Ein Kamerasystem zur verbesserten Tumordetektion während chirurgischer oder endoskopischer Eingriffe wurde entwickelt, und in der klinischen Praxis erprobt. Mit Hilfe der optischen Bildgebung, in Verbindung mit spezifischen fluoreszierenden Kontrastmitteln, wurden molekulare Strukturen der erkrankten Zellen visualisiert. Zusammen mit neuen Algorithmen für die multispektrale Aufnahme und Korrektur von Fluoreszenzbildern in biologischem Gewebe kann das entwickelte System die Krebsdiagnose und -therapie entscheidend verbessern.

Published
2015

19. Molecular Fluorescence Endoscopy Targeting Vascular Endothelial Growth Factor A for Improved Colorectal Polyp Detection

Author

Tjalma, Jolien J., primary, Garcia-Allende, P. Beatriz, additional, Hartmans, Elmire, additional, Terwisscha van Scheltinga, Anton G., additional, Boersma-van Ek, Wytske, additional, Glatz, Jürgen, additional, Koch, Maximilian, additional, van Herwaarden, Yasmijn J., additional, Bisseling, Tanya M., additional, Nagtegaal, Iris D., additional, Timmer-Bosscha, Hetty, additional, Koornstra, Jan Jacob, additional, Karrenbeld, Arend, additional, Kleibeuker, Jan H., additional, van Dam, Gooitzen M., additional, Ntziachristos, Vasilis, additional, and Nagengast, Wouter B., additional

Published
2015
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27. 653 Towards Instant Detection of (Pre)Malignant Lesions by Ultrasensitive Near-Infrared Fluorescence Endoscopy, Using Molecular Targeted Fluorescent Antibodies

Author

Tjalma, Jolien J., primary, Garcia-Allende, P. Beatriz, additional, Terwisscha van Scheltinga, Anton, additional, Glatz, Jürgen, additional, Hartmans, Elmire, additional, van Oosten, Marleen, additional, Koornstra, Jan J., additional, Kleibeuker, Jan H., additional, van Dam, Gooitzen M., additional, Ntziachristos, Vasilis, additional, and Nagengast, Wouter B., additional

Published
2013
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30. Molecular Fluorescence Endoscopy Targeting Vascular Endothelial Growth Factor A for Improved Colorectal Polyp Detection.

Author

Tjalma, Jolien J., Garcia-Allende, P. Beatriz, Hartmans, Elmire, van Scheltinga, Anton G. Terwisscha, Boersma-van Ek, Wytske, Glatz, Jürgen, Koch, Maximilian, van Herwaarden, Yasmijn J., Bisseling, Tanya M., Nagtegaal, Iris D., Timmer-Bosscha, Hetty, Koornstra, Jan Jacob, Karrenbeld, Arend, Kleibeuker, Jan H., van Dam, Gooitzen M., Ntziachristos, Vasilis, and Nagengast, Wouter B.

Published
2016
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32. Fluorescently labeled bevacizumab in human breast cancer: defining the classification threshold

Author

Brown, J. Quincy, van Leeuwen, Ton G., Koch, Maximilian, de Jong, Johannes S., Glatz, Jürgen, Symvoulidis, Panagiotis, Lamberts, Laetitia E., Adams, Arthur L. L., Kranendonk, Mariëtte E. G., Terwisscha van Scheltinga, Anton G. T., Aichler, Michaela, Jansen, Liesbeth, de Vries, Jakob, Lub-de Hooge, Marjolijn N., Schröder, Carolien P., Jorritsma-Smit, Annelies, Linssen, Matthijs D., de Boer, Esther, van der Vegt, Bert, Nagengast, Wouter B., Elias, Sjoerd G., Oliveira, Sabrina, Witkamp, Arjen J., Mali, Willem P. Th. M., Van der Wall, Elsken, Garcia-Allende, P. Beatriz, van Diest, Paul J., de Vries, Elisabeth G. E., Walch, Axel, van Dam, Gooitzen M., and Ntziachristos, Vasilis

Published
2017
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39. Spectral unmixing using component analysis in multispectral optoacoustic tomography

Author

Morscher, Stefan, Glatz, Jürgen, Deliolanis, Nikolaos C., Buehler, Andreas, Sarantopoulos, Athanasios, Razansky, Daniel, and Ntziachristos, Vasilis

Abstract

Multispectral optoacoustic (photoacoustic) tomography (MSOT) exploits high resolutions given by ultrasound detection technology combined with deeply penetrating laser illumination in the near infrared. Traces of molecules with different spectral absorption profiles, such as blood (oxy- and de-oxygenated) and biomarkers can be recovered using multiple wavelengths excitation and a set of methods described in this work. Three unmixing methods are examined for their performance in decomposing images into components in order to locate fluorescent contrast agents in deep tissue in mice. Following earlier works we find Independent Component Analysis (ICA), which relies on the strong criterion of statistical independence of components, as the most promising approach, being able to clearly identify concentrations that other approaches fail to see. The results are verified by cryosectioning and fluorescence imaging.

Published
2011
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