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260 results on '"Glassford, Neil J."'

5. Haemodynamic effect of a 20% albumin fluid bolus in postcardiac surgery patients

Author

Cutuli, Salvatore L, Bitker, Laurent, Osawa, Eduardo A, O'Brien, Zachary, Canet, Emmanuel, Yanase, Fumitaka, Ancona, Paolo, Wilson, Anthony, Lucchetta, Luca, Kubicki, Mark, Cronhjort, Maria, Cioccari, Luca, Peck, Lea, Young, Helen, Eastwood, Glenn M, Martensson, Johan, Glassford, Neil J, and Bellomo, Rinaldo

Published
2020

12. Ventilation management in Victorian intensive care unit patients without acute respiratory distress syndrome

Author

Eyeington, Christopher T., Glassford, Neil J., Darvall, Jai, Casamento, Andrew, Haydon, Tim, Taori, Gopal, Knott, Cameron, McGain, Forbes, Vetro, Joseph, Simpson, Nick, Sarode, Vineet, Richardson, Angus, Dunnachie, Charles, Crisman, Marco, Musci, Jason, Woinarski, Nicholas, Lynham, Rohan, Eastwood, Glenn M., Bellomo, Rinaldo, and Karalapillai, Dharshi

Published
2018
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19. Small volume resuscitation with 20% albumin in intensive care: physiological effects

Author

Mårtensson, Johan, Bihari, Shailesh, Bannard-Smith, Jonathan, Glassford, Neil J., Lloyd-Donald, Patryck, Cioccari, Luca, and Luethi, Nora

Subjects
Medical colleges -- Physiological aspects -- Research, Albumin -- Research -- Physiological aspects, Hospital patients -- Physiological aspects -- Research, Health care industry
Abstract

Purpose We set out to assess the resuscitation fluid requirements and physiological and clinical responses of intensive care unit (ICU) patients resuscitated with 20% albumin versus 4-5% albumin. Methods We performed a randomised controlled trial in 321 adult patients requiring fluid resuscitation within 48 h of admission to three ICUs in Australia and the UK. Results The cumulative volume of resuscitation fluid at 48 h (primary outcome) was lower in the 20% albumin group than in the 4-5% albumin group [median difference - 600 ml, 95% confidence interval (CI) - 800 to - 400; P < 0.001]. The 20% albumin group had lower cumulative fluid balance at 48 h (mean difference - 576 ml, 95% CI - 1033 to - 119; P = 0.01). Peak albumin levels were higher but sodium and chloride levels lower in the 20% albumin group. Median (interquartile range) duration of mechanical ventilation was 12.0 h (7.6, 33.1) in the 20% albumin group and 15.3 h (7.7, 58.1) in the 4-5% albumin group (P = 0.13); the proportion of patients commenced on renal replacement therapy after randomization was 3.3% and 4.2% (P = 0.67), respectively, and the proportion discharged alive from ICU was 97.4% and 91.1% (P = 0.02). Conclusions Resuscitation with 20% albumin decreased resuscitation fluid requirements, minimized positive early fluid balance and was not associated with any evidence of harm compared with 4-5% albumin. These findings support the safety of further exploration of resuscitation with 20% albumin in larger randomised trials. Trial registration http://www.anzctr.org.au. Identifier ACTRN12615000349549., Author(s): Johan Mårtensson [sup.1] [sup.2] [sup.13], Shailesh Bihari [sup.3] [sup.4], Jonathan Bannard-Smith [sup.5], Neil J. Glassford [sup.1], Patryck Lloyd-Donald [sup.1], Luca Cioccari [sup.1] [sup.6], Nora Luethi [sup.1], Aiko Tanaka [sup.1] [...]

Published
2018
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20. Defining the characteristics and expectations of fluid bolus therapy: A worldwide perspective

Author

Arabi, Yaseen, Bagshaw, Sean M., Bannard-Smith, Jonathan, Bin, Du, Dubin, Arnaldo, Duranteau, Jacques, Echeverri, Jorge, Hoste, Eric, Joannidis, Michael, Kashani, Kianoush, Kellum, John, Kulkarni, Atul P., Landoni, Giovanni, Candal, Christina Lluch, Matejovic, Martin, Yunos, Nor'azim Modh, Nichol, Alistair, van Straaten, Heleen Oudemans, Perner, Anders, Pettila, Ville, Phua, Jason, Hernandez, Glenn, Puxty, Alex, Reinhart, Konrad, Richards, Guy, Schneider, Antoine, Tsuji, Isabella, Uchino, Shigehiko, Glassford, Neil J., Mårtensson, Johan, Eastwood, Glenn M., Jones, Sarah L., Tanaka, Aiko, Wilkman, Erica, Bailey, Michael, and Bellomo, Rinaldo

Published
2016
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36. The nature and discriminatory value of urinary neutrophil gelatinase-associated lipocalin in critically ill patients at risk of acute kidney injury

Author

Glassford, Neil J., Schneider, Antoine G., Xu, Shengyuan, Eastwood, Glenn M., Young, Helen, Peck, Leah, and Venge, Per

Subjects
Ethylenediaminetetraacetic acid, Enzymes, Health care industry
Abstract

Background Different molecular forms of urinary neutrophil gelatinase-associated lipocalin (NGAL) have recently been discovered. We aimed to explore the nature, source and discriminatory value of urinary NGAL in intensive care unit (ICU) patients. Methods We simultaneously measured plasma NGAL (pNGAL), urinary NGAL (uNGAL), and estimated monomeric and homodimeric uNGAL contribution using Western blotting-validated enzyme-linked immunosorbent assays [uNGAL.sub.E1 and uNGAL.sub.E2] and their calculated ratio in 102 patients with the systemic inflammatory response syndrome and oliguria, and/or a creatinine rise of >25 [mu]mol/L. Measurements and main results Bland-Altman analysis demonstrated that, despite correlating well (r = 0.988), uNGAL and uNGAL.sub.E1 were clinically distinct, lacking both accuracy and precision (bias: 266.23; 95 % CI 82.03-450.44 ng/mg creatinine; limits of agreement: -1,573.86 to 2,106.32 ng/mg creatinine). At best, urinary forms of NGAL are fair (area under the receiver operating characteristic [AUROC] [less than or equal to]0.799) predictors of renal or patient outcome; most perform significantly worse. The 44 patients with a primarily monomeric source of uNGAL had higher pNGAL (118.5 ng/ml vs. 72.5 ng/ml; p < 0.001), remaining significant following Bonferroni correction. Conclusions uNGAL is not a useful predictor of outcome in this ICU population. uNGAL patterns may predict distinct clinical phenotypes. The nature and source of uNGAL are complex and challenge the utility of NGAL as a uniform biomarker., Author(s): Neil J. Glassford [sup.1], Antoine G. Schneider [sup.1], Shengyuan Xu [sup.2], Glenn M. Eastwood [sup.1], Helen Young [sup.1], Leah Peck [sup.1], Per Venge [sup.2], Rinaldo Bellomo [sup.1] [sup.3] Author [...]

Published
2013
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37. Choice of renal replacement therapy modality and dialysis dependence after acute kidney injury: a systematic review and meta-analysis

Author

Schneider, Antoine G., Bellomo, Rinaldo, Bagshaw, Sean M., Glassford, Neil J., Lo, Serigne, Jun, Min, and Cass, Alan

Subjects
Chronic kidney failure -- Analysis, Health care industry
Abstract

Purpose Choice of renal replacement therapy (RRT) modality may affect renal recovery after acute kidney injury (AKI). We sought to compare the rate of dialysis dependence among severe AKI survivors according to the choice of initial renal replacement therapy (RRT) modality applied [continuous (CRRT) or intermittent (IRRT)]. Methods Systematic searches of peer-reviewed publications in MEDLINE and EMBASE were performed (last update July 2012). All studies published after 2000 reporting dialysis dependence among survivors from severe AKI requiring RRT were included. Data on follow-up duration, sex, age, chronic kidney disease, illness severity score, vasopressors, and mechanical ventilation were extracted when available. Results were pooled using a random-effects model. Results We identified 23 studies: seven randomized controlled trials (RCTs) and 16 observational studies involving 472 and 3,499 survivors, respectively. Pooled analyses of RCTs showed no difference in the rate of dialysis dependence among survivors (relative risk, RR 1.15 [95 % confidence interval (CI) 0.78-1.68], I.sup.2 = 0 %). However, pooled analyses of observational studies suggested a higher rate of dialysis dependence among survivors who initially received IRRT as compared with CRRT (RR 1.99 [95 % CI 1.53-2.59], I.sup.2 = 42 %). These findings were consistent with adjusted analyses (performed in 7/16 studies), which found a higher rate of dialysis dependence in IRRT-treated patients [odds ratio (OR) 2.2-25 (5 studies)] or no difference (2 studies). Conclusions Among AKI survivors, initial treatment with IRRT might be associated with higher rates of dialysis dependence than CRRT. However, this finding largely relies on data from observational trials, potentially subject to allocation bias, hence further high-quality studies are necessary., Author(s): Antoine G. Schneider [sup.1] [sup.2], Rinaldo Bellomo [sup.1] [sup.2], Sean M. Bagshaw [sup.3], Neil J. Glassford [sup.1] [sup.2], Serigne Lo [sup.4], Min Jun [sup.4], Alan Cass [sup.4], Martin Gallagher [...]

Published
2013
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43. Acute kidney injury in sepsis

Author

Bellomo, Rinaldo, Kellum, John A., Ronco, Claudio, Wald, Ron, Martensson, Johan, Maiden, Matthew, Bagshaw, Sean M., Glassford, Neil J., Lankadeva, Yugeesh, Vaara, Suvi, Schneider, Antoine, Department of Diagnostics and Therapeutics, Anestesiologian yksikkö, Clinicum, and HUS Perioperative, Intensive Care and Pain Medicine

Subjects
INTENSIVE-CARE-UNIT, GOAL-DIRECTED RESUSCITATION, BLOOD-FLOW, Renal replacement therapy, SEPTIC SHOCK, RANDOMIZED CONTROLLED-TRIAL, urologic and male genital diseases, female genital diseases and pregnancy complications, Acute kidney injury, CLINICAL-TRIAL, CONSENSUS CONFERENCE, REPLACEMENT THERAPY, Recovery, Sepsis, Creatinine, 3121 General medicine, internal medicine and other clinical medicine, CRITICALLY-ILL PATIENTS, Biomarkers, ACUTE-RENAL-FAILURE
Abstract

Acute kidney injury (AKI) and sepsis carry consensus definitions. The simultaneous presence of both identifies septic AKI. Septic AKI is the most common AKI syndrome in ICU and accounts for approximately half of all such AKI. Its pathophysiology remains poorly understood, but animal models and lack of histological changes suggest that, at least initially, septic AKI may be a functional phenomenon with combined microvascular shunting and tubular cell stress. The diagnosis remains based on clinical assessment and measurement of urinary output and serum creatinine. However, multiple biomarkers and especially cell cycle arrest biomarkers are gaining acceptance. Prevention of septic AKI remains based on the treatment of sepsis and on early resuscitation. Such resuscitation relies on the judicious use of both fluids and vasoactive drugs. In particular, there is strong evidence that starch-containing fluids are nephrotoxic and decrease renal function and suggestive evidence that chloride-rich fluid may also adversely affect renal function. Vasoactive drugs have variable effects on renal function in septic AKI. At this time, norepinephrine is the dominant agent, but vasopressin may also have a role. Despite supportive therapies, renal function may be temporarily or completely lost. In such patients, renal replacement therapy (RRT) becomes necessary. The optimal intensity of this therapy has been established, while the timing of when to commence RRT is now a focus of investigation. If sepsis resolves, the majority of patients recover renal function. Yet, even a single episode of septic AKI is associated with increased subsequent risk of chronic kidney disease.

Published
2017

46. Acute kidney injury in sepsis

Author

Bellomo, Rinaldo, primary, Kellum, John A., additional, Ronco, Claudio, additional, Wald, Ron, additional, Martensson, Johan, additional, Maiden, Matthew, additional, Bagshaw, Sean M., additional, Glassford, Neil J., additional, Lankadeva, Yugeesh, additional, Vaara, Suvi T., additional, and Schneider, Antoine, additional

Published
2017
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48. Defining the characteristics and expectations of fluid bolus therapy: A worldwide perspective

Author

Glassford, Neil J., primary, Mårtensson, Johan, additional, Eastwood, Glenn M., additional, Jones, Sarah L., additional, Tanaka, Aiko, additional, Wilkman, Erica, additional, Bailey, Michael, additional, Bellomo, Rinaldo, additional, Arabi, Yaseen, additional, Bagshaw, Sean M., additional, Bannard-Smith, Jonathan, additional, Bin, Du, additional, Dubin, Arnaldo, additional, Duranteau, Jacques, additional, Echeverri, Jorge, additional, Hoste, Eric, additional, Joannidis, Michael, additional, Kashani, Kianoush, additional, Kellum, John, additional, Kulkarni, Atul P., additional, Landoni, Giovanni, additional, Candal, Christina Lluch, additional, Matejovic, Martin, additional, Yunos, Nor'azim Modh, additional, Nichol, Alistair, additional, van Straaten, Heleen Oudemans, additional, Perner, Anders, additional, Pettila, Ville, additional, Phua, Jason, additional, Hernandez, Glenn, additional, Puxty, Alex, additional, Reinhart, Konrad, additional, Richards, Guy, additional, Schneider, Antoine, additional, Tsuji, Isabella, additional, and Uchino, Shigehiko, additional

Published
2016
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