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Background Laser treatments for facial rejuvenation are common, with ablative modalities being of more common use for this indication. Efficient nonablative modalities are of rising demand. Aim Our aim was to determine the safety and efficacy of high-fluence, nonablative 1540-nm fractional Erbium:glass laser for facial rejuvenation. Patients and methods A retrospective study of patients treated with 3-4 treatments using the 1540-nm fractional Erbium:glass laser for facial rejuvenation, using 2500-3000 mJ/stacked pulses (51-61 mJ per pixel). Patients were followed-up for 3 months following their last treatment. Before and after photos were independently blindly evaluated by 2 dermatologists, who graded them using a scale from 0 (exacerbation) to 4 (76%-100% improvement) for 2 different facial regions (frontal face region and lateral canthal region). Pain perception and adverse effects as well as patient satisfaction were documented throughout the study. Results Sixteen patients completed both treatment and follow-up period. At the 3-months posttreatment follow-up visit, moderate-to-significant improvement in rhytids appearance (mean grade of improvement: 2.93 for frontal face and 3 for lateral canthal region) was observed. Patients' satisfaction was high (4.25). Patients reported mild and transient erythema posttreatment with no other adverse effects. Conclusion The high-fluence 1540-nm fractional Erbium:glass laser is a safe and effective nonablative modality for facial rejuvenation.

We present the results of an experimental study of soft X-ray (SXR) and extreme ultraviolet emission spectra of the plasma produced by exposing a plane solid beryllium target to laser radiation with broad frequency and angular spectra. SXR lines up to 1s – 9p of Be IV as well as the plasma continuum are recorded for a laser focal-spot intensity of 5.3 × 1013 W cm−2. To model the SXR beryllium plasma spectra, simulations are carried out using the INDHAUS programme and the FLYCHK code in the framework of local thermodynamic equilibrium model, which agree nicely with experimentally obtained results.

Background Androgenic alopecia is common, chronic dermatologic disorder. A variety of lasers and light sources appear to be safe and effective in the treatment of AGA. Aims To evaluate the efficacy and safety of 1540-nm fractional erbium glass laser in the treatment of AGA. Patients/methods This was an interventional therapeutic study for the treatment of patients with AGA. The patients received 10 sessions with 1540-nm fractional erbium glass laser at 2-week intervals. The assessment of the response was done before and at the end of follow-up period, both objectively (the change in the density of terminal hair and the diameter of the hair shaft) and subjectively (patient satisfaction). Any adverse effects were documented during the study. Results Forty-seven out of 51 patients completed the study. After 5 months of laser treatment, the density of hair and hair thickness was significantly increased in both males and females (P value .001). Conclusion The 1540-nm fractional erbium-glass laser seems to be an effective and safe option for treatment of patients with AGA. The improvement was accomplished in a short period.

Background and objectives Varieties of laser and light sources have been tried for treatment of alopecia areata (AA) and some success has been reported. To assess the effectiveness of 1,540 nm fractional erbium-glass laser in treatment of AA. Study design/materials and methods The patches of AA were divided into two groups, the study group (I) underwent six sessions of laser therapy at weekly interval with topical minoxidil solution applied twice daily for 6 weeks, while group (II), the control group was received only topical minoxidil solution. The patches were evaluated objectively (hair count and percentage of regrowth) and subjectively (patient satisfaction) at the end of follow-up period (another 6 weeks). Results The percentage of hair increment between pre-treatment and follow-up period was 30% for study patches versus 6.45% for control patches. Regarding the percentage of growth, the response rate for study patches was 60% versus 16% for the control. Conclusions Erbium-glass laser seems to be effective in regrowing hair in AA. The durability of the response is unknown. Possible mechanisms of improvement include the induction of a thermal effect on papillary dermis, which stimulates hair regrowth, or an immunological effect on the follicle. In addition, the erbium-glass laser may enhance the delivery of minoxidil solution. Lasers Surg. Med. © 2019 Wiley Periodicals, Inc.

Ultralow phase-noise mode-locked lasers are crucial for real-world applications. We present two accomplishments: (1) short-term FF CEP stabilization of a SESAM mode-locked Er:Yb:glass laser at 1.55 um with timing jitter below 3 as (1-3 MHz) and (2) a hybrid solution adding a FB technique addressing slowly varying sources of interference to the FF system that demonstrates 75 hours of stabilization with a minimally detrimental effect amounting to a timing jitter of 11 as.

The National Ignition Facility (NIF) at Lawrence Livermore National Laboratory contains a 192-beam 4.2 MJ neodymium glass laser (around 1053 nm or 1w) that is frequency converted to 351nm light or 3w. It has been designed to support the study of Inertial Confinement Fusion (ICF) and High Energy Density Physics (HEDP). The NIF Precision Diagnostic System (PDS) was reactivated and new diagnostic packages were designed and fielded that offer a more comprehensive suite of high-resolution measurements. The current NIF laser performance will be presented as well as the preliminary results obtained with the various laser experimental campaigns using the new diagnostic tool suites.

We report the first (to the best of our knowledge) high-power, low-coherence Nd:glass laser delivering kilojoule pulses with a coherent time of 249 fs and a bandwidth of 13 nm, achieving the 63%-efficiency second-harmonic conversion of the large-aperture low-coherence pulse and good beam smoothing effect. It provides a new type of laser driver for laser plasma interaction and high energy density physics research.

BACKGROUND Novel picosecond lasers using a diffractive optical element (P-DOE) have been available for skin resurfacing with distinct mechanisms. However, there are limited data directly comparing P-DOE and conventional fractional lasers for the treatment of atrophic acne scarring. OBJECTIVES We sought to compare the efficacy and safety of a 1064-nm neodymium-doped yttrium aluminium garnet P-DOE and a non-ablative fractional laser (NAFL) in the treatment of acne scarring. METHODS A prospective, randomized, split-face, controlled trial was performed. One randomly assigned half-side of each patient's face (n = 25) was treated with four consecutive sessions of P-DOE at 3-week intervals and the other side with NAFL, with subsequent follow-up for 8 weeks after the final sessions. The efficacy and safety of the two lasers were determined by the Echelle d'Evaluation Clinique des Cicatrices d'acne (Scale of Clinical Evaluation of Acne Scars; ECCA) grading scale, Investigator's Global Assessment (IGA) score and patients' reports at the final visit. Histologic analysis was also performed. RESULTS The P-DOE-treated side achieved a significantly better improvement in acne appearance (ECCA per cent reduction: 55% vs. 42%) with less severe pain (4.3 vs. 5.6) (P

We present carrier-envelope phase stabilization of an Er:Yb:glass laser at 1.55 pm via the feed-forward method with 2.9 as (1 Hz - 3 MHz) timing jitter and continuous stabilization over 24 hours.

BACKGROUND AND OBJECTIVE Striae distensae (SD) represent therapeutically challenging forms of dermal atrophic scarring. In addition to topical ointments, medical needling and various energy-based devices, non-ablative fractional lasers have been suggested for their improvement. However, objective evaluations of their efficacy are widely missing. In this study, we aimed to assess the clinical improvement of SD albae after three treatments with a non-ablative fractional 1565 nm Er: glass laser by employing three-dimensional analysis and several questionnaires. METHODS A total of 16 Caucasians suffering from SD albae were included in this prospective study. Every patient received three treatments - one every 4 weeks - using a non-ablative, fractional 1565 nm laser (two passes: 300 μbeams/cm2 , 40 mJ inside the SD; 150 μbeams/cm2 , 50 mJ inside the SD and within the surrounding area). Questionnaires (DLQI, POSAS), digital photography and three-dimensional analysis employing PRIMOS® software and VECTRA® camera system were taken at baseline, 1 and 6 months after the last treatment. RESULTS Evaluation of objective measurements at 6-month follow-up (FU) showed a significant reduction in depth of atrophic lesions by 31.7% and less skin irregularities with Smax at baseline of 621.2 μm decreasing to 411.6 μm (P

The impact of spectral phase noise on the temporal pulse contrast is explored experimentally by using two zero-dispersion stretchers (Offner stretcher and two-lens stretcher). The results show clearly that a long temporal pedestal appears when there exists far-field spectral phase noise, which greatly degrades the pulse contrast. In our proof-of-principle experiment, by using a two-lens stretcher, the far-field spectral phase noise is avoided and the noise pedestal of the amplified pulse in a Nd:glass laser system is reduced, with the contrast reaching a level of 10 –11 in the 60-ps time window before the main pulse. This simple method may pave the way in a PW-level Nd:glass laser by directly using pre-cleaning techniques.

Schamberg's disease is one of the pigmented purpuric dermatoses (PPD). PPD encompass a large and heterogeneous group of dermatologic disorders featuring purpuric lesions often located on the lower limbs. The various forms of PPD are notoriously known to be resistant to treatment. Fractional photothermolysis has been described as a successful and safe method to induce dermal remodeling. We report three patients with Schamberg's disease who were successfully treated with 4 monthly sessions of fractional non-ablative 1540 nm erbium:glass laser, with resolution of their purpuric pigmented rash lasting up to 9 months after the last treatment session.

Glass paste for laser bonding is composed of low melting point glass powder, organic carrier and additives. As the particle size of glass powder is increasing, the crack defects of glass frit film ...

An optimized therapeutic regimen involving a non-ablative fractionated laser or radiofrequency therapy for acne scars has not yet been established. To evaluate whether the combination of a non-ablative fractional laser (NAF) and fractional micro-needling radiofrequency (FMR) has clinical advantages for the treatment of atrophic acne scars compared with NAF alone, a 16-week prospective, randomized split-face study was performed. Each facial side of a patient was treated with 3 sessions of either NAF with FMR or NAF alone, with a 4-week interval between each session. Although both sides demonstrated significant decreases in the échelle d’évaluation clinique des cicatrices d’acné (ECCA) score, the facial side treated using the combination regimen demonstrated greater improvement in ECCA score regarding degree and onset time than the NAF-treated side. Histopathological and immunohistochemical results confirmed the clinical findings. This study demonstrated that a combination regimen involving NAF and FMR could be a viable option with satisfactory efficacy.

The aim of this work was to investigate the utilization of Co:Spinel as saturable absorber for eye-safe Er:YAG laser generating at 1645 nm wavelength. Co:Spinel (Co:MgAl 2 O 4 , Co:MALO) absorber is used to Q-switching for laser systems generating about 1.5 μm wavelength, for example for Er:glass laser. Due to lower radiation absorption above the 1.55 μm wavelength of Co:spinel, the another passive absorbers were investigated, e.g. U:SrF 2 [1], Co:GSGG [2], and Cr:ZnSe [3]. However, the advantage of Co:Spinel is its high damage threshold and therefore, the research of its utilization would be prolonged, especially for 1.6 μm Er:YAG laser.

Fractional 1550-nm erbium-glass (Er:Glass) laser therapy is effective in inducing hair regrowth. Combining fractional Er:Glass laser therapy with topical minoxidil may yield therapeutic benefits for patients with androgenetic alopecia (AGA). To compare the efficacy and safety of fractional Er:Glass laser used in combination with topical 5% minoxidil versus 5% minoxidil alone for the treatment of male AGA, 30 men with AGA were randomized to 24 weeks of split-scalp treatment using fractional Er:Glass laser and 5% minoxidil on one side (combined therapy) or 5% minoxidil alone on the other side (monotherapy). The primary outcome was the difference in hair density and diameter, from baseline, between two treatment sides, at week 24. The secondary outcome was a global photographic assessment, evaluated by two dermatologists and the participants. Adverse events were evaluated. Twenty-nine participants completed the 24-week study period. Combination therapy provided significantly superior results for both the primary and secondary outcomes (all p

The possibility of using bursts of microsecond pulses of an Yb,Er : glass laser (λ = 1.54 μm) for cataract destruction was investigated experimentally in vitro for the first time. The energy in a laser pulse was limited from below by the eye lens destruction threshold and from above by the radiation resistance of the input end face of the radiation-supplying fibre. The energy of a burst consisting of three microsecond laser pulses, separated by time intervals of 850 μs, was 255 ± 15 mJ, and the burst repetition rate was 15 Hz. The hydroacoustic signal, generated after each burst pulse in the water around the lens, contained two components. The first occurred immediately after the laser pulse transmission, and the second was delayed by 250 to 350 μs. The amplitude of the second component of the hydroacoustic signal exceeded the amplitude of the first component and was maximum (50.0 ± 8.0 MPa) for the signal induced by the second pulse in the burst. The efficiency of cataract destruction by microsecond-pulse bursts generated by an Yb,Er : glass laser was found to depend on the lens nucleus density, to exceed significantly the efficiency of cataract destruction by single microsecond pulses of this laser, and to be comparable with the efficiency of eye lens destruction by a 1.44-μm Nd : YAG laser.