74 results on '"Glaeser D"'
Search Results
2. Properties of Highly Conducting Polyacetylene
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Schimmel, Th., Gläser, D., Schwoerer, M., Naarmann, H., Brédas, J. L., editor, and Silbey, R., editor
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- 1991
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- View/download PDF
Catalog
3. Successful stem cell transplantation in a patient with primary cutaneous aggressive cytotoxic epidermotropic CD8+ T-cell lymphoma
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Wehkamp, U., Glaeser, D., Oschlies, I., Hilgendorf, I., Klapper, W., and Weichenthal, M.
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- 2015
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- View/download PDF
4. Generation of a human iPSC line (HIMRi001-A) from a patient with filaminopathy
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Daya, N.M., Mavrommatis, L., Zhuge, H., Athamneh, M., Roos, A., Gläser, D., Doering, K., Zaehres, H., Vorgerd, M., and Güttsches, A.K.
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- 2023
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5. CYCLOSPORINE A IN COMBINATION WITH MYCOPHENOLATE MOFETIL OR METHOTREXATE FOR PROPHYLAXIS OF GVHD: PH-P387
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Dübbers, M., Borchert, K., Glaeser, D., Schmitt, M., Junghanss, C., and Hilgendorf, I.
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- 2014
6. Juvenile autophagic vacuolar myopathy – a new entity or variant?
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Stenzel, W., Nishino, I., von Moers, A., Kadry, M. A., Glaeser, D., Heppner, F. L., and Goebel, H.-H.
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- 2013
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7. Liberação do parasitoide Cotesia flavipes (Hymenoptera: Braconidae) em Diatraea saccharalis (Lepidoptera: Crambidae) na cana-de-açúcar
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RÔDAS, P. L., OLIVEIRA, H. N. de, GLAESER, D. F., PRISCILA LARANJEIRA RÔDAS, BIÓLOGA, HARLEY NONATO DE OLIVEIRA, CPAO, and DANIELE FABIANA GLAESER, BOLSISTA PÓS-DOUTORANDA FUNDECT/CAPES.
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Broca ,Emergência ,Pests ,Biological control ,Natural enemies ,Inimigo Natural ,Controle Biológico ,Drills ,Praga ,Sugarcane - Abstract
Made available in DSpace on 2019-11-20T00:43:18Z (GMT). No. of bitstreams: 1 36923.pdf: 340862 bytes, checksum: d6899b07800ae1ba982c852474293a4b (MD5) Previous issue date: 2019
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- 2019
8. Conventional heart rate variability analysis of ambulatory electrocardiographic recordings fails to predict imminent ventricular fibrillation
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Vybiral, T, Glaeser, D. H, Goldberger, A. L, Rigney, D. R, Hess, K. R, Mietus, J, Skinner, J. E, Francis, M, and Pratt, C. M
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Life Sciences (General) - Abstract
OBJECTIVES. The purpose of this report was to study heart rate variability in Holter recordings of patients who experienced ventricular fibrillation during the recording. BACKGROUND. Decreased heart rate variability is recognized as a long-term predictor of overall and arrhythmic death after myocardial infarction. It was therefore postulated that heart rate variability would be lowest when measured immediately before ventricular fibrillation. METHODS. Conventional indexes of heart rate variability were calculated from Holter recordings of 24 patients with structural heart disease who had ventricular fibrillation during monitoring. The control group consisted of 19 patients with coronary artery disease, of comparable age and left ventricular ejection fraction, who had nonsustained ventricular tachycardia but no ventricular fibrillation. RESULTS. Heart rate variability did not differ between the two groups, and no consistent trends in heart rate variability were observed before ventricular fibrillation occurred. CONCLUSIONS. Although conventional heart rate variability is an independent long-term predictor of adverse outcome after myocardial infarction, its clinical utility as a short-term predictor of life-threatening arrhythmias remains to be elucidated. more...
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- 1993
9. Teste de vôo como critério de avaliação da qualidade de Palmistichus elaeisis Delvare & LaSalle (Hymenoptera: eulophidae)
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FELTRIN-CAMPOS, E., RÔDAS, P. L., GLAESER, D. F., PEREIRA, F. F., OLIVEIRA, H. N. de, ELIDIANE FELTRIN-CAMPOS, PÓS GRADUAÇÃO EM ENTOMOLOGIA E CONSERVAÇÃO DA BIODIVERSIDADE - UNIVERSIDADE FEDERAL DA GRANDE DOURADOS, DOURADOS, PRISCILA LARANJEIRA RÔDAS, PÓS GRADUAÇÃO EM ENTOMOLOGIA E CONSERVAÇÃO DA BIODIVERSIDADE, UNIVERSIDADE FEDERAL DA GRANDE DOURADOS, dOURADOS, DANIELE FABIANA GLAESER, BOLSISTA PÓS-DOC PNPD/FUNDECT, FABRÍCIO FAGUNDES PEREIRA, DOCENTE - UNIVERSIDADE FEDERAL DA GRANDE DOURADOS - DOURADOS, and HARLEY NONATO DE OLIVEIRA, CPAO. more...
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Praga ,Inimigos naturais ,Pest ,biological control ,Controle Biológico ,Parasitoide ,natural enemies ,Laboratório ,Laboratory ,Parasitoid - Published
- 2016
10. Genetic and neurodevelopmental spectrum of SYNGAP1-associated intellectual disability and epilepsy
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Mignot, C., von Stulpnage, C., Nava, C., Ville, D., Sanlaville, D., Lesca, G., Rastetter, A., Gachet, B., Marie, Y., Korenke, G. C., Borggraefe, I., Hoffmann-Zacharska, D., Szczepanik, E., Rudzka-Dybala, M., Uluc, Yis, Caglayan, H., Isapof, A., Marey, I., Panagiotakaki, E., Korff, C., Rossier, E., Riess, A., Beck-Woedl, S., Rauch, A., Zweier, C., Hoyer, J., Reis, A., Mironov, M., Bobylova, M., Mukhin, K., Hernandez-Hernandez, L., Maher, B., Sisodiya, S., Kuhn, M., Glaeser, D., Wechuysen, S., Myers, C. T., Mefford, H. C., Hortnagel, K., Biskup, S., Lemke, J. R., Heron, D., Kluger, G., Depienne, C., Craiu, D., De Jonghe, P., Helbig, I., Guerrini, R., Lehesjoki, A. -E., Marini, C., Muhle, H., Moller, R. S., Neubauer, B., Pal, D., Selmer, K., Stephani, U., Sterbova, K., Striano, P., Talvik, T., von Spiczak, S., Service de génétique, cytogénétique, embryologie [Pitié-Salpétrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Pierre et Marie Curie - Paris 6 (UPMC), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Groupe de Recherche Clinique : Déficience Intellectuelle et Autisme (GRC), Université Pierre et Marie Curie - Paris 6 (UPMC), Paracelsus Medizinische Privatuniversität = Paracelsus Medical University (PMU), Hospital for Neuropediatrics and Neurological Rehabilitation, Epilepsy Center for Children and Adolescents, Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Neurologie Pédiatrique [CHU Lyon], Hôpital Femme Mère Enfant [CHU - HCL] (HFME), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Centre de recherche en neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de Génétique [HCL Groupement Hospitalier Est], Groupement hospitalier Lyon-Est, Université de Lyon, Klinikum Oldenburg [Oldenburg], Zentrum für Kinder- und Jugendmedizin, Dpt of Pediatric Neurology and Developmental Medicine and Epilepsy Center [Munich], University of Munich, Department of Medical Genetics, Institute of Mother and Child, Division of Child Neurology, Dokuz Eylül Üniversitesi = Dokuz Eylül University [Izmir] (DEÜ), Dpt of Molecular Biology and Genetics Istanbul, Boǧaziçi üniversitesi = Boğaziçi University [Istanbul], Service de Neuropédiatrie [CHU Trousseau], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Epilepsie, sommeil et explorations fonctionnelles neuropédiatriques, Hospices Civils de Lyon (HCL)-Hôpital Femme Mère Enfant, Dpt de l'Enfant et de l'Adolescent, Neuropédiatrie [Genève], Hôpitaux Universitaires de Genève (HUG), Institute of Human Genetics [Tuebingen], University of Tuebingen, Institute of Medical Genetics and Applied Genomics [Tübingen], University of Tübingen, Institute of Medical Genetics, Universität Zürich [Zürich] = University of Zurich (UZH), Institute of Human Genetics [Erlangen, Allemagne], Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Svt. Luka's Institute of Child Neurology and Epilepsy, Department of Clinical and Experimental Epilepsy, University College of London [London] (UCL), Genetikum, Neurogenetics Group, Division of Genetic Medicine [Seattle], University of Washington [Seattle], CeGaT GmbH, Institut für Humangenetik, Universität Heidelberg [Heidelberg], Mignot, Cyril, von Stülpnagel, Celina, Korff, Christian, EuroEPINOMICS-RES MAE Working Grp, HAL-UPMC, Gestionnaire, Service de génétique, cytogénétique, embryologie [CHU Pitié-Salpétrière], Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Groupement Hospitalier Lyon-Est (GHE), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Université Pierre et Marie Curie - Paris 6 (UPMC), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Boğaziçi University [Istanbul], CHU Trousseau [APHP], and Universität Heidelberg [Heidelberg] = Heidelberg University more...
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0301 basic medicine ,Pediatrics ,medicine.medical_specialty ,Encephalopathy ,Myoclonic Jerk ,SYNGAP1 ,03 medical and health sciences ,Epilepsy ,0302 clinical medicine ,fluids and secretions ,Medizinische Fakultät ,Intellectual disability ,mental disorders ,Genetics ,medicine ,ddc:610 ,[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Exome ,Genetics (clinical) ,reproductive and urinary physiology ,ddc:618 ,business.industry ,medicine.disease ,Hypotonia ,3. Good health ,030104 developmental biology ,Autism ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Human medicine ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
Mae Euroepinomics-Res Mae; International audience; Objective We aimed to delineate the neurodevelopmental spectrum associated with SYNGAP1 mutations and to investigate genotype–phenotype correlations.Methods We sequenced the exome or screened the exons of SYNGAP1 in a total of 251 patients with neurodevelopmental disorders. Molecular and clinical data from patients with SYNGAP1 mutations from other centres were also collected, focusing on developmental aspects and the associated epilepsy phenotype. A review of SYNGAP1 mutations published in the literature was also performed.Results We describe 17 unrelated affected individuals carrying 13 different novel loss-of-function SYNGAP1 mutations. Developmental delay was the first manifestation of SYNGAP1-related encephalopathy; intellectual disability became progressively obvious and was associated with autistic behaviours in eight patients. Hypotonia and unstable gait were frequent associated neurological features. With the exception of one patient who experienced a single seizure, all patients had epilepsy, characterised by falls or head drops due to atonic or myoclonic seizures, (myoclonic) absences and/or eyelid myoclonia. Triggers of seizures were frequent (n=7). Seizures were pharmacoresistant in half of the patients. The severity of the epilepsy did not correlate with the presence of autistic features or with the severity of cognitive impairment. Mutations were distributed throughout the gene, but spared spliced 3′ and 5′ exons. Seizures in patients with mutations in exons 4–5 were more pharmacoresponsive than in patients with mutations in exons 8–15.Conclusions SYNGAP1 encephalopathy is characterised by early neurodevelopmental delay typically preceding the onset of a relatively recognisable epilepsy comprising generalised seizures (absences, myoclonic jerks) and frequent triggers. more...
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- 2016
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11. P.211Pilot study of genetic newborn screening for spinal muscular atrophy in Germany: clinical results after more than a year
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Mueller-Felber, W., Kölbel, H., Schwartz, O., Blaschek, A., Olgemüller, B., Harms, E., Röschinger, W., Durner, J., Gläser, D., Burggraf, S., Nennstiel, U., Wirth, B., Schara, U., Becker, M., and Vill, K. more...
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- 2019
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12. Compound heterozygosity for FGFR3 gene mutations in a family with hypochondroplasia
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Winterpacht, A., Steglich, C., Salzgeber, K., and Glaeser, D.
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Genetic disorders -- Research ,Dysplasia -- Genetic aspects ,Fibroblast growth factors -- Abnormalities ,Human genetics -- Research ,Biological sciences - Published
- 2001
13. Basic Knowledge of Healthy People 2010 by Emergency Physicians at Emergency Medicine Residency Training Programs
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Irvin, CB, Glaeser, D, and Wheaton, DJ
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Health promotion -- Evaluation ,Physician and patient -- Communication ,Emergency physicians -- Surveys ,Health - Published
- 2001
14. Pathological non-response to chemotherapy in a neoadjuvant setting of breast cancer: an inter-institutional study
- Author
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Balmativola, D., Marchio, C., Maule, M., Chiusa, L., Annaratone, L., Maletta, F., Montemurro, F., Kulka, J., Figueiredo, P., Varga, Z., Liepniece-Karele, I., Cserni, G., Arkoumani, E., Amendoeira, I., Callagy, G., Reiner-Concin, A., Cordoba, A., Bianchi, S., Decker, T., Glaeser, D., Focke, C., van Diest, P., Grabau, Dorthe, Lips, E., Wesseling, J., Arisio, R., Medico, E., Wells, C., Sapino, A., Balmativola, D., Marchio, C., Maule, M., Chiusa, L., Annaratone, L., Maletta, F., Montemurro, F., Kulka, J., Figueiredo, P., Varga, Z., Liepniece-Karele, I., Cserni, G., Arkoumani, E., Amendoeira, I., Callagy, G., Reiner-Concin, A., Cordoba, A., Bianchi, S., Decker, T., Glaeser, D., Focke, C., van Diest, P., Grabau, Dorthe, Lips, E., Wesseling, J., Arisio, R., Medico, E., Wells, C., and Sapino, A. more...
- Abstract
To identify markers of non-response to neoadjuvant chemotherapy (NAC) that could be used in the adjuvant setting. Sixteen pathologists of the European Working Group for Breast Screening Pathology reviewed the core biopsies of breast cancers treated with NAC and recorded the clinico-pathological findings (histological type and grade; estrogen, progesterone receptors, and HER2 status; Ki67; mitotic count; tumor-infiltrating lymphocytes; necrosis) and data regarding the pathological response in corresponding surgical resection specimens. Analyses were carried out in a cohort of 490 cases by comparing the groups of patients showing pathological complete response (pCR) and partial response (pPR) with the group of non-responders (pathological non-response: pNR). Among other parameters, the lobular histotype and the absence of inflammation were significantly more common in pNR (p < 0.001). By ROC curve analyses, cut-off values of 9 mitosis/2 mm(2) and 18 % of Ki67-positive cells best discriminated the pNR and pCR + pPR categories (p = 0.018 and < 0.001, respectively). By multivariable analysis, only the cut-off value of 9 mitosis discriminated the different response categories (p = 0.036) in the entire cohort. In the Luminal B/HER2- subgroup, a mitotic count < 9, although not statistically significant, showed an OR of 2.7 of pNR. A lobular histotype and the absence of inflammation were independent predictors of pNR (p = 0.024 and < 0.001, respectively). Classical morphological parameters, such as lobular histotype and inflammation, confirmed their predictive value in response to NAC, particularly in the Luminal B/HER2- subgroup, which is a challenging breast cancer subtype from a therapeutic point of view. Mitotic count could represent an additional marker but has a poor positive predictive value. more...
- Published
- 2014
15. P044 Interlaboratory variability of Ki67-labelling index in breast cancer tissue microarrays
- Author
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Focke, C.M., Bürger, H., Korsching, E., Gläser, D., Finsterbusch, K., and Decker, T.
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- 2015
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16. P030 Impact of different Ki67 assessment methods on St.Gallen subtyping of breast cancer
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Focke, C.M., Gläser, D., Finsterbusch, K., and Decker, T.
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- 2015
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17. Successful stem cell transplantation in a patient with primary cutaneous aggressive cytotoxic epidermotropic CD8+ T-cell lymphoma.
- Author
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Wehkamp, U., Glaeser, D., Oschlies, I., Hilgendorf, I., Klapper, W., and Weichenthal, M.
- Subjects
- *
STEM cell transplantation , *T-cell lymphoma , *HISTOPATHOLOGY , *SKIN disease treatment , *CYTOTOXIC T cells - Abstract
The article discusses the case of a 48-year-old man who have undergone stem cell transplantation (SCT) after he has been diagnosed of cutaneous T-cell lymphoma (CTCL). Topics covered include histopathological examination of the patient's skin prior the treatment, T-cell receptor (TCR) rearrangement due to CTCL, and incidence of primary cutaneous aggressive cytotoxic epidermotropic CD8+ TCL (PCAE-TCL). The outcome of SCT procedure is also mentioned. more...
- Published
- 2015
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18. Left ventricular volume reduction and reconstruction in ischemic cardiomyopathy.
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García-Rinaldi, Raúl, Soltero, Ernesto R., Carballido, Jorge, Mojica, Joaquín, González-Cruz, Juan, Cosme, Octavio, Glaeser, Donald H., García-Rinaldi, R, Soltero, E R, Carballido, J, Mojica, J, González-Cruz, J, Cosme, O, and Glaeser, D H more...
- Published
- 1999
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19. Computer Monitoring in Patient Care.
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Glaeser, D H and Thomas, L J
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- 1975
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20. A Quantising Encoder.
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Cox, J. R. and Glaeser, D. H.
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- 1964
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21. Hemodynamic Effects of Different Pacing Ratios in Chronic Dynamic Double Cardiomyoplasty
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Soltero, E. R., Glaeser, D. H., Michael, L. H., Hartley, C. J., Earle, N. R., Li, Z., and Lawrie, G. M.
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- 1996
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22. Bolted Field Repair of Composite Structures.
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MCDONNELL AIRCRAFT CO ST LOUIS MO, Watson,James B, Glaeser,D A, Harvey,F L, Fukimoto,W T, Padilla,V E, MCDONNELL AIRCRAFT CO ST LOUIS MO, Watson,James B, Glaeser,D A, Harvey,F L, Fukimoto,W T, and Padilla,V E more...
- Abstract
Mechanically fastened, field repairs for graphite/epoxy laminates 3/16 and 1/2 inch thick with through-the-thickness hole damage have been successfully demonstrated. These repairs (titanium alloy patches and backing plates), were developed for application on fuel cell composite wing surfaces and can be installed by maintenance personnel in the field using available equipment, materials, and methods. A total of 28 specimens were fabricated and tested statically to evaluate effectiveness of selected repair designs. more...
- Published
- 1979
23. Alteration of diastolic filling rate during exercise radionuclide angiography: a highly sensitive technique for detection of coronary artery disease.
- Author
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Poliner, L R, primary, Farber, S H, additional, Glaeser, D H, additional, Nylaan, L, additional, Verani, M S, additional, and Roberts, R, additional
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- 1984
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24. Infrarenal Abdominal Aortic Aneurysm
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CRAWFORD, E. S., primary, SALEH, S. A., additional, BABB, J. W., additional, GLAESER, D. H., additional, VACCARO, P S., additional, and SILVERS, A., additional
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- 1982
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25. Left ventricular diastolic performance at rest and during exercise in patients with coronary artery disease. Assessment with first-pass radionuclide angiography.
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Reduto, L A, primary, Wickemeyer, W J, additional, Young, J B, additional, Del Ventura, L A, additional, Reid, J W, additional, Glaeser, D H, additional, Quinones, M A, additional, and Miller, R R, additional more...
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- 1981
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26. The influence of residual disease after coronary bypass on the 5-year survival rate of 1274 men with coronary artery disease.
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Lawrie, G M, primary, Morris, G C, additional, Silvers, A, additional, Wagner, W F, additional, Baron, A E, additional, Beltangady, S S, additional, Glaeser, D H, additional, and Chapman, D W, additional more...
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- 1982
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27. Patterns of atherosclerosis: effect of risk factors on recurrence and survival-analysis of 11,890 cases with more than 25-year follow-up.
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DeBakey, Michael E., Glaeser, Donald H., DeBakey, M E, and Glaeser, D H
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ATHEROSCLEROSIS , *DISEASE relapse - Abstract
A series of 11,890 patients from the senior investigator's surgical service between 1949 and 1998 is analyzed for the significance of distinct risk factors for recurrence of, and survival from, atherosclerotic occlusive disease. Eight risk factors have been assessed for their importance in 4 defined arterial categories (the coronary arterial bed, the branches of the aorta, the abdominal visceral [celiac, superior mesenteric, and renal] arteries, and the terminal abdominal aorta and its major branches) in determining survival rate of the entire group and their impact on rate of recurrence of atherosclerosis in a subgroup of 5,568 patients who had > or =1 postoperative arteriogram, permitting precise identification of changes in the atherosclerotic process. Patients in these 2 groups were followed for > or =25 years; univariate and multivariate analyses were used. On admission all patients had symptomatic atherosclerotic occlusive disease in a single vascular category. Each patient was treated surgically for alleviation of the disease. Two primary outcomes are included: (1) survival, by atherosclerosis category, in all 11,890 patients; and (2) recurrence, also by category, in the subset of 5,568 patients. Multivariate results for recurrence showed little consistency across categories. Only 1 risk factor, diabetes, appeared in 2 of the 3 categories fully analyzed. Other variables that are significant in only a single category are male sex, cholesterol, hypertension, and smoking. Survival showed much greater consistency, with age, diabetes, and hypertension significant in all 3 categories, male sex and smoking in 2, and cholesterol in only Category I. Univariate results followed much the same trend. For recurrence and survival, the response of the arterial bed to the risk factors in each of the 4 categories is distinctly different, an observation that we have not found to be previously reported. [ABSTRACT FROM AUTHOR] more...
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- 2000
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28. Longitudinal observation of anxiety and depression among palliative care cancer patients.
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Sewtz C, Muscheites W, Grosse-Thie C, Kriesen U, Leithaeuser M, Glaeser D, Hansen P, Kundt G, Fuellen G, and Junghanss C
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- Aged, Anxiety etiology, Depression epidemiology, Depression etiology, Humans, Prospective Studies, Neoplasms, Palliative Care
- Abstract
Background: Anxiety and depressive symptoms are commonly reported to have a high prevalence in advanced cancer patients. However, whether the severity of the symptoms change during a stay in a palliative care unit (PCU) and after discharge home has not been studied thus far. This prospective, longitudinal, single-center study screened for anxiety and depression as measured on the German version of Hospital Anxiety and Depression Scale (HADS-D) in a palliative care (PC) cancer cohort at three different time points., Methods: Consecutive patients (N=206) admitted to a PCU were evaluated of whom N=102 could be enrolled. Patients were screened for anxiety and depression using the HADS-D questionnaire: 24 h after admittance (P1), within 24 h before discharge (P2) and 2 weeks after discharge (P3). Longitudinal changes and influencing factors were determined., Results: Nearly 80% of all patients had at least at one time point a HADS score ≥8 indicating a clinically meaningful symptom burden. The P1 mean scores were 7.1±3.3 (anxiety) and 8.9±4.6 (depression). Depression was associated with underlying cancer type (P<0.05). Anxiety and depression stabilized during hospitalization (P2). However, a significant deterioration after discharge (P3) was observed (anxiety P=0.046; depression P=0.003), in particular in older patients (>65 years) and higher ECOG status (≥3). Patients with a short time since first diagnosis (<1 year) had significantly higher symptom burden compared to patients with a longer disease course. Participation was 50% emphasizing the difficulty to study PC patients. Most patients had advanced cancers (99%). Underlying cancer types consisted of a broad variety of solid tumors including 15% hematological cases. Median survival was 1.1 months., Conclusions: The high prevalence of anxiety and depressive symptoms points to the need for psychological support. All PC patients should be screened for psychological distress to identify those in need of further assessment and treatment. The deterioration at home suggests the need for improved outpatient management, including home-based psychological support. Caregivers should be aware of the psychological vulnerability of newly diagnosed cancer patients, patients with lower functional status and higher age. more...
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- 2021
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29. MPV17 mutations in juvenile- and adult-onset axonal sensorimotor polyneuropathy.
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Baumann M, Schreiber H, Schlotter-Weigel B, Löscher WN, Stucka R, Karall D, Strom TM, Bauer P, Krabichler B, Fauth C, Glaeser D, and Senderek J
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- Adolescent, Adult, Age of Onset, Axons pathology, Child, Failure to Thrive genetics, Failure to Thrive physiopathology, Female, Heredodegenerative Disorders, Nervous System genetics, Heredodegenerative Disorders, Nervous System physiopathology, Humans, Liver Diseases genetics, Liver Diseases physiopathology, Liver Failure genetics, Liver Failure physiopathology, Male, Mitochondrial Diseases genetics, Mitochondrial Diseases physiopathology, Peripheral Nervous System Diseases physiopathology, Polyneuropathies physiopathology, Sensorimotor Cortex physiopathology, Young Adult, Genetic Predisposition to Disease, Membrane Proteins genetics, Mitochondrial Proteins genetics, Peripheral Nervous System Diseases genetics, Polyneuropathies genetics
- Abstract
MPV17 encodes a putative channel-forming protein of the inner mitochondrial membrane and is involved in mitochondrial deoxynucleotide homeostasis. MPV17 mutations were first reported in patients with Navajo neurohepatopathy, an autosomal recessive mitochondrial DNA depletion syndrome, characterized by early-onset liver failure, failure to thrive as well as central and peripheral neurological involvement. Recently, two patients with juvenile-onset peripheral sensorimotor neuropathy associated with an MVP17 c.122G>A (p.Arg41Gln) variant have been reported. Here, we describe five additional patients from two unrelated families with sensorimotor axonal neuropathy without hepatocerebral affection caused by homozygous MPV17 variants. Patients of the first family carried the known c.122G>A variant and affected individuals of the second family had a novel c.376-9T>G near-splice variant, which was shown to result in an in-frame deletion of 11 amino acids. This report provides further evidence that MPV17 mutations should be considered in patients with pure, non-syndromic axonal neuropathy., (© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.) more...
- Published
- 2019
- Full Text
- View/download PDF
30. Genetic and neurodevelopmental spectrum of SYNGAP1-associated intellectual disability and epilepsy.
- Author
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Mignot C, von Stülpnagel C, Nava C, Ville D, Sanlaville D, Lesca G, Rastetter A, Gachet B, Marie Y, Korenke GC, Borggraefe I, Hoffmann-Zacharska D, Szczepanik E, Rudzka-Dybała M, Yiş U, Çağlayan H, Isapof A, Marey I, Panagiotakaki E, Korff C, Rossier E, Riess A, Beck-Woedl S, Rauch A, Zweier C, Hoyer J, Reis A, Mironov M, Bobylova M, Mukhin K, Hernandez-Hernandez L, Maher B, Sisodiya S, Kuhn M, Glaeser D, Weckhuysen S, Myers CT, Mefford HC, Hörtnagel K, Biskup S, Lemke JR, Héron D, Kluger G, and Depienne C more...
- Abstract
Objective: We aimed to delineate the neurodevelopmental spectrum associated with SYNGAP1 mutations and to investigate genotype-phenotype correlations., Methods: We sequenced the exome or screened the exons of SYNGAP1 in a total of 251 patients with neurodevelopmental disorders. Molecular and clinical data from patients with SYNGAP1 mutations from other centres were also collected, focusing on developmental aspects and the associated epilepsy phenotype. A review of SYNGAP1 mutations published in the literature was also performed., Results: We describe 17 unrelated affected individuals carrying 13 different novel loss-of-function SYNGAP1 mutations. Developmental delay was the first manifestation of SYNGAP1-related encephalopathy; intellectual disability became progressively obvious and was associated with autistic behaviours in eight patients. Hypotonia and unstable gait were frequent associated neurological features. With the exception of one patient who experienced a single seizure, all patients had epilepsy, characterised by falls or head drops due to atonic or myoclonic seizures, (myoclonic) absences and/or eyelid myoclonia. Triggers of seizures were frequent (n=7). Seizures were pharmacoresistant in half of the patients. The severity of the epilepsy did not correlate with the presence of autistic features or with the severity of cognitive impairment. Mutations were distributed throughout the gene, but spared spliced 3' and 5' exons. Seizures in patients with mutations in exons 4-5 were more pharmacoresponsive than in patients with mutations in exons 8-15., Conclusions: SYNGAP1 encephalopathy is characterised by early neurodevelopmental delay typically preceding the onset of a relatively recognisable epilepsy comprising generalised seizures (absences, myoclonic jerks) and frequent triggers., (Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/) more...
- Published
- 2016
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31. EMQN best practice guidelines for the molecular genetic testing and reporting of fragile X syndrome and other fragile X-associated disorders.
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Biancalana V, Glaeser D, McQuaid S, and Steinbach P
- Subjects
- 5' Untranslated Regions, Alleles, Ataxia genetics, DNA Methylation, Female, Fragile X Syndrome genetics, Humans, Male, Mutation, Phenotype, Primary Ovarian Insufficiency genetics, Promoter Regions, Genetic, RNA, Messenger metabolism, Tremor genetics, Ataxia diagnosis, Fragile X Mental Retardation Protein genetics, Fragile X Syndrome diagnosis, Genetic Testing standards, Practice Guidelines as Topic, Primary Ovarian Insufficiency diagnosis, Tremor diagnosis
- Abstract
Different mutations occurring in the unstable CGG repeat in 5' untranslated region of FMR1 gene are responsible for three fragile X-associated disorders. An expansion of over ∼200 CGG repeats when associated with abnormal methylation and inactivation of the promoter is the mutation termed 'full mutation' and is responsible for fragile X syndrome (FXS), a neurodevelopmental disorder described as the most common cause of inherited intellectual impairment. The term 'abnormal methylation' is used here to distinguish the DNA methylation induced by the expanded repeat from the 'normal methylation' occurring on the inactive X chromosomes in females with normal, premutation, and full mutation alleles. All male and roughly half of the female full mutation carriers have FXS. Another anomaly termed 'premutation' is characterized by the presence of 55 to ∼200 CGGs without abnormal methylation, and is the cause of two other diseases with incomplete penetrance. One is fragile X-associated primary ovarian insufficiency (FXPOI), which is characterized by a large spectrum of ovarian dysfunction phenotypes and possible early menopause as the end stage. The other is fragile X-associated tremor/ataxia syndrome (FXTAS), which is a late onset neurodegenerative disorder affecting males and females. Because of the particular pattern and transmission of the CGG repeat, appropriate molecular testing and reporting is very important for the optimal genetic counselling in the three fragile X-associated disorders. Here, we describe best practice guidelines for genetic analysis and reporting in FXS, FXPOI, and FXTAS, including carrier and prenatal testing. more...
- Published
- 2015
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32. The effect of an instant hand sanitizer on blood glucose monitoring results.
- Author
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Mahoney JJ, Ellison JM, Glaeser D, and Price D
- Subjects
- Adult, Aged, Blood Glucose analysis, Female, Humans, Male, Middle Aged, Anti-Infective Agents, Local therapeutic use, Blood Glucose drug effects, Blood Glucose Self-Monitoring methods, Diabetes Mellitus blood, Ethanol therapeutic use, Hand Disinfection methods
- Abstract
Background: People with diabetes mellitus are instructed to clean their skin prior to self-monitoring of blood glucose to remove any dirt or food residue that might affect the reading. Alcohol-based hand sanitizers have become popular when soap and water are not available. The aim of this study was to determine whether a hand sanitizer is compatible with glucose meter testing and effective for the removal of exogenous glucose., Methods: We enrolled 34 nonfasting subjects [14 male/20 female, mean ages 45 (standard deviation, 9.4)] years, 2 with diagnosed diabetes/32 without known diabetes]. Laboratory personnel prepared four separate fingers on one hand of each subject by (1) cleaning the second finger with soap and water and towel drying (i.e., control finger), (2) cleaning the third finger with an alcohol-based hand sanitizer, (3) coating the fourth finger with cola and allowing it to air dry, and (4) coating the fifth finger with cola and then cleaning it with the instant hand sanitizer after the cola had dried. Finger sticks were performed on each prepared finger and blood glucose was measured. Several in vitro studies were also performed to investigate the effectiveness of the hand sanitizer for removal of exogenous glucose.z, Results: Mean blood glucose values from fingers cleaned with instant hand sanitizer did not differ significantly from the control finger (p = .07 and .08, respectively) and resulted in 100% accurate results. Blood glucose data from the fourth (cola-coated) finger were substantially higher on average compared with the other finger conditions, but glucose data from the fifth finger (cola-coated then cleaned with hand sanitizer) was similar to the control finger. The data from in vitro experiments showed that the hand sanitizer did not adversely affect glucose meter results, but when an exogenous glucose interference was present, the effectiveness of the hand sanitizer on glucose bias (range: 6% to 212%) depended on the surface area and degree of dilution., Conclusions: In our study, use of an instant hand sanitizer was compatible with the results of a blood glucose monitor and did not affect finger stick blood glucose results. However, depending on surface area, hand sanitizers may not be adequate for cleaning the skin prior to glucose meter testing., (© 2011 Diabetes Technology Society.) more...
- Published
- 2011
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33. Unique occurrence of Brachmann-de Lange syndrome in a fetus whose mother presented with a diffuse large B-cell lymphoma.
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Schiffer C, Schiesser M, Lehr J, Tariverdian G, Glaeser D, Gabriel H, Mikuz G, and Sergi C
- Subjects
- Adult, Antineoplastic Agents therapeutic use, De Lange Syndrome genetics, Female, Fetal Diseases genetics, Genetic Testing, Humans, Lymphoma, Large B-Cell, Diffuse drug therapy, Male, Pregnancy, Pregnancy Trimester, Second, De Lange Syndrome diagnosis, Fetal Diseases diagnosis, Lymphoma, Large B-Cell, Diffuse diagnosis
- Abstract
Brachmann-De Lange Syndrome (BDLS, MIM 122470) is a rare multiple congenital anomaly/mental retardation syndrome characterized by a variable phenotype including intrauterine fetal growth retardation, limb reduction and distinctive facial and skull features (low frontal hairline, synophrys, anteverted nostrils, long philtrum, downturned corners of the mouth, micro- and retrognathia, low-set ears and micro-/brachycephaly), as well as a significant psychological developmental delay. A proposed classification system for BDLS include a classic type with characteristic facial and skull changes, a mild type where similar changes may develop with time or may be partially expressed, and a third type including phenocopies, where phenotypic changes are casually related to chromosomal aneuploidies or teratogenic exposures. We report on a 22-week gestation fetus with BDLS, showing intrauterine fetal growth retardation, brachycephaly, micro-/retrognathia and monolateral single bone of the forearm, in a woman harboring diffuse large B-cell lymphoma. Meticulous family history was negative for malformations, syndromes, congenital anomalies or psychiatric disorders. There are very few reports of BDLS at early gestation, but to the best of our knowledge, this is the first case occurring simultaneously with a hematological neoplastic disease of the mother. more...
- Published
- 2007
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34. Acute impairment of coronary blood flow by dynamic cardiomyoplasty.
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Soltero ER, Glaeser DH, Michael LH, Hartley CJ, Earle NR, and Lawrie GM
- Subjects
- Animals, Assisted Circulation adverse effects, Dogs, Myocardial Contraction physiology, Assisted Circulation methods, Coronary Circulation physiology, Electric Stimulation Therapy, Muscles transplantation, Myocardial Ischemia etiology, Surgical Flaps
- Abstract
The aim of this study was to quantify the effects of three different configurations of cardiomyoplasty on coronary blood flow in an acute dog model. Thirteen dogs had both latissimus dorsi muscles harvested and transposed to the chest. Coronary blood flow was measured using Doppler cuff probes on the left anterior descending and circumflex coronary arteries during each of three cardiomyoplasty configurations: left posterior, right anterior, and double. Multiple beat measures were made of systolic and diastolic flow during a control protocol and a subsequent protocol with the muscle(s) paced. Significant flow reductions during pacing were observed in the left anterior descending coronary artery during left posterior (17%, p = 0.003), right anterior (29%, p < 0.0001), and double (35%, p = 0.0001) myoplasty. Similar reductions occurred in the circumflex artery (14%, p = 0.0009; 20%, p = 0.001; 27%, p = 0.0053). The net flow over an entire pacing cycle also was reduced significantly: left anterior descending artery (11%, p = 0.0035; 23%, p = 0.0001; 23%, p = 0.0047) and circumflex artery (10%, p = 0.0025; 17%, p = 0.0018; 21%, p = 0.0091). Thus, in the acute setting cardiomyoplasty depresses coronary blood flow. A chronic setting will be needed to determine the ultimate significance of these results. more...
- Published
- 1994
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35. Effects of low dose transdermal scopolamine on heart rate variability in acute myocardial infarction.
- Author
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Vybiral T, Glaeser DH, Morris G, Hess KR, Yang K, Francis M, and Pratt CM
- Subjects
- Administration, Cutaneous, Aged, Double-Blind Method, Electrocardiography, Ambulatory, Humans, Male, Middle Aged, Myocardial Infarction diagnosis, Myocardial Infarction mortality, Parasympathetic Nervous System drug effects, Scopolamine administration & dosage, Scopolamine pharmacology, Stimulation, Chemical, Stroke Volume, Time Factors, Heart Rate drug effects, Myocardial Infarction drug therapy, Myocardial Infarction physiopathology, Scopolamine therapeutic use
- Abstract
Objectives: We hypothesized that by enhancing parasympathetic activity, low dose transdermal scopolamine would increase heart rate variability after myocardial infarction., Background: Low heart rate variability is associated with increased mortality after acute myocardial infarction., Methods: Conventional time domain heart rate variability was measured from 24-h Holter recordings of 61 consecutive male patients (mean age 58 +/- 10 years, left ventricular ejection fraction 44.7 +/- 15.5%) 6 days (median) after acute myocardial infarction. Patients were then randomly assigned to wear one patch of transdermal scopolamine or a matching placebo patch for 24 h, during which their 24-h heart rate variability was remeasured., Results: Compared with placebo, transdermal scopolamine caused a significant increase in time domain measures of 24-h heart rate variability by 26% to 35% above baseline. Transdermal scopolamine was well tolerated., Conclusions: Low dose transdermal scopolamine safely increases cardiac parasympathetic activity and short-term heart rate variability after acute myocardial infarction. Whether the effect of transdermal scopolamine on heart rate variability is a reasonable surrogate for improvement of long-term morbidity and mortality requires an appropriate designed investigation. more...
- Published
- 1993
- Full Text
- View/download PDF
36. New configuration of double cardiomyoplasty based on studies of the length-tension properties of the latissimus dorsi muscle.
- Author
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Soltero ER, Michael LH, Glaeser DH, Hartley CJ, Earle NR, and Lawrie GM
- Subjects
- Acute Disease, Animals, Back, Dogs, Heart Failure physiopathology, Heart Failure surgery, Hemodynamics, Muscles transplantation, Cardiac Surgical Procedures methods, Muscle Contraction physiology, Muscles physiology, Surgical Flaps methods, Ventricular Function, Left physiology
- Abstract
A new configuration of double cardiomyoplasty was designed according to studies of the length-tension properties of the linear latissimus dorsi muscle. Four dogs had both their right and left latissimus dorsi muscles dissected from the chest wall and attached to a tensiometer to measure force of contraction. The maximum active tension obtained with stimulation of the linear latissimus dorsi muscle was observed when the muscle was at its resting anatomic length and up to 5% above this length. Eight dogs had a double cardiomyoplasty in which the resting anatomic length of both muscles was maintained. Control hemodynamic parameters obtained with the muscles at rest were compared with stimulated muscle protocols. In a normal heart state, stimulation of the double cardiomyoplasty increased the cardiac output 32% (p < 0.05), the stroke volume 39% (p < 0.05), and the left ventricular pressure 42% (p < 0.05). When acute heart failure was induced with high-dose intravenous propranolol (5 mg/kg), stimulation of the double cardiomyoplasty increased the cardiac output 32% (p = 0.01), the stroke volume 32% (p < 0.05), rate of pressure rise 39% (p < 0.01), and myocardial thickening 39% (p < 0.01). The study demonstrated that this configuration of double cardiomyoplasty provides significant hemodynamic assistance in the normal and acutely failing canine heart. more...
- Published
- 1993
37. Influence of diabetes mellitus on the results of coronary bypass surgery. Follow-up of 212 diabetic patients ten to 15 years after surgery.
- Author
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Lawrie GM, Morris GC Jr, and Glaeser DH
- Subjects
- Coronary Angiography, Diabetes Complications, Diabetes Mellitus therapy, Female, Follow-Up Studies, Heart Diseases mortality, Humans, Hypoglycemic Agents therapeutic use, Insulin therapeutic use, Male, Middle Aged, Probability, Coronary Artery Bypass, Diabetes Mellitus mortality
- Abstract
To determine the long-term influence of the severity of preoperative diabetes mellitus on the results of coronary bypass, a review was made of 212 diabetics operated on between 1968 and 1973, of whom 87 patients (41%) were receiving no drugs, 108 patients (50.9%) were receiving oral hypoglycemic agents, and 17 patients (8%) were receiving insulin. They were compared with 1,222 nondiabetic patients operated on over the same period. Perioperative mortality was similar in the diabetics and nondiabetics: 7.1% vs 4.5%. Improvement in anginal symptoms was similar in all patient groups: 85.9% to 92.7%. Overall 15-year survival probability was .53 for the nondiabetic group, .43 for the diabetics not receiving drugs, .33 for those receiving oral agents, and .19 for the insulin-treated patients. Late graft patency ranged from 78% to 90% and was comparable in all groups. The preoperative blood glucose level was an important predictor of late mortality in all diabetic patients. Thus, coronary bypass surgery was effective in all groups of diabetic patients in long-term relief of anginal symptoms. Intermediate-term survival rates were good in all groups, but the initial severity of the diabetes was an important determinant of long-term survival rates. more...
- Published
- 1986
38. A hierarchical minicomputer system for continuous post-surgical monitoring.
- Author
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Glaeser DH, Trost RF, Brown DB, Kyle AC, Lenahan MS, Walker CK, Wilson CS, and DeBakey ME
- Subjects
- Analog-Digital Conversion, Blood Pressure, Body Temperature, Cardiac Output, Data Display, Electrocardiography, Heart Rate, Online Systems, Vascular Resistance, Venous Pressure, Computers, Monitoring, Physiologic, Postoperative Care
- Published
- 1975
- Full Text
- View/download PDF
39. A semiautomated technique for the rapid evaluation of left ventricular regional wall motion.
- Author
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Cole JS, Holland PA, and Glaeser DH
- Subjects
- Computers, Coronary Disease diagnostic imaging, Coronary Disease physiopathology, Humans, Male, Ventricular Function, Angiocardiography methods, Cineangiography methods
- Abstract
A semiautomated system for the rapid evaluation of left ventricular regional wall motion is described. The system includes direct projection of the cineangiogram film on an X-Y digitizer which is interfaced with a PDP-9 computer. The ventricular model used to evaluate regional wall motion and the methods of data analysis are described. Validation of the accuracy of the technique and specific clinical applications are presented. It is concluded that this technique provides a rapid means of evaluating left ventricular regional wall motion and that the accuracy of the technique is acceptable for clinical application. more...
- Published
- 1976
- Full Text
- View/download PDF
40. Infrarenal abdominal aortic aneurysm: factors influencing survival after operation performed over a 25-year period.
- Author
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Crawford ES, Saleh SA, Babb JW 3rd, Glaeser DH, Vaccaro PS, and Silvers A
- Subjects
- Adolescent, Adult, Age Factors, Aged, Aortic Aneurysm mortality, Aortic Rupture mortality, Aortic Rupture surgery, Coronary Disease complications, Female, Humans, Hypertension complications, Male, Middle Aged, Retrospective Studies, Risk, Smoking, Aorta, Abdominal surgery, Aortic Aneurysm surgery, Kidney surgery
- Abstract
This report is concerned with the factors influencing survival in 920 consecutive patients submitted to operation for infrarenal abdominal aortic aneurysm during the past 25 years. Rupture had occurred in 60 patients (6.5%) and survival was 77%, which did not vary during the period of study. Of the 860 patients (93.5%) treated for nonrupture, 819 (95%) survived operation. The mortality rate in this group varied from 18%, in the earlier period to 1.43% , in recent years. Risk factors including heart disease, hypertension, and advanced age accounted for 95% of the deaths that occurred within 30 days however, the mortality rate in patients with these problems decreased from 19.2% to 1.9% during the period of study although the average number of patients treated each year with these risk factors increased tenfold. Improvements in operative techniques and experience were responsible for decreasing mortality up to about 1971. Subsequent decrease in mortality was due to improvements in anesthesia, monitoring, and other supportive measures during operation and the early recovery period. Complete survival information was obtained in 816 (99.6%) patients, 191 of whom had been treated for periods over 15 years. Factors influencing long-term survival were associated disease and age at time of operation. Survival in percentage in patients without associated heart disease of hypertension for 5, 10, and 15 years was 84, 49, and 21; with heart disease, it was 54, 34, and 17. The median age of patients in the series was 65.5 years and survival at above intervals according to quartile was less than or equal to 60; 71, 53, and 24; 60 less than age less than or equal to 71; 66, 38, and 18; less greater than 71; 43, 13, and 11. more...
- Published
- 1981
- Full Text
- View/download PDF
41. Determinants of survival 10 to 14 years after coronary bypass: analysis of preoperative variables in 1,448 patients.
- Author
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Lawrie GM, Morris GC Jr, Baron A, Norton J, and Glaeser DH
- Subjects
- Coronary Disease diagnosis, Follow-Up Studies, Heart Function Tests, Humans, Middle Aged, Preoperative Care, Prognosis, Risk, Statistics as Topic, Time Factors, Coronary Artery Bypass mortality
- Abstract
To determine which preoperative variables were most predictive of long-term survival after coronary bypass surgery, the status of 1,448 consecutive patients was determined 10 to 14 years after operation. All patients were operated on at least 10 years ago and follow-up at 10 years was 93.8% complete. The overall 14-year survival probabilities were: for one-vessel disease, 73.3%; for two-vessel disease, 45.9%; for three-vessel disease, 34.2%; and for left main coronary artery disease, 41.9%. Patients with good left ventricular function had an overall survival rate of 53.3%, and patients with poor ventricular function had a survival rate of 31.9%. Preoperative variables predictive of greater risk of total mortality were: digoxin usage, multivessel disease, poor quality of left ventricular function, age at operation, electrocardiographic evidence of myocardial infarction, previous stroke, diabetes, heart failure, diuretic usage, cigarette smoking, and residual ungrafted coronary artery disease. The major determinants of long-term survival were variables associated with preoperative left ventricular function. Diabetes was the only important metabolic risk factor identified. This study suggests that unfavorable preoperative conventional risk factors should not be considered a contraindication to operation in patients with adequate coronary anatomy and left ventricular function. more...
- Published
- 1987
- Full Text
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42. Late results of reconstructive surgery for renovascular disease.
- Author
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Lawrie GM, Morris GC Jr, Soussou ID, Starr DS, Silvers A, Glaeser DH, and DeBakey ME
- Subjects
- Adolescent, Adult, Age Factors, Aged, Blood Pressure, Cerebrovascular Disorders complications, Child, Child, Preschool, Female, Follow-Up Studies, Humans, Hypertension, Renovascular complications, Hypertension, Renovascular mortality, Male, Middle Aged, Myocardial Infarction complications, Neoplasms complications, Sex Factors, Thrombosis surgery, Arteriosclerosis surgery, Hypertension, Renal surgery, Hypertension, Renovascular surgery, Renal Artery Obstruction surgery
- Abstract
In order to determine the late results of reconstructive surgery for renovascular disease, a review was made of a series of 505 consecutive patients who underwent operation over a 20-year period. There were 257 males (50.9%) with an age range of 3-80 years. Renal artery bypass grafts were used in 75.4% (471/625) and thromboendarterectomy and/or patch angioplasty in 15.0% (94/625) of reconstructions. Associated vascular procedures were performed in 38.0% (186/489) of patients. Operative mortality (30-day) was 1.8% (9/489) overall, and 4.8% (9/186) with associated procedures but there was no operative mortality in 303 consecutive isolated renal artery reconstructions. The blood pressure was normal or improved in 65% of patients at a mean follow-up interval of 49.3 months, range 1-240 months. The best response rate was obtained in younger patients with isolated renal lesions. Linear regression analysis showed age at operation to be the most important determinant of blood pressure response (p < 0.003) with the presence or absence of diffuse atherosclerosis as another but less powerful determinant of responsiveness (p < 0.07). Crude 15-year survival was 70% (340/489). The overall five- and ten-year actuarial survival probabilities were 80 and 62% respectively. The most common causes of death were myocardial infarction, stroke, and cancer. Cox regression analysis for variables influencing survival indicated that age at operation (p < 0.001), sex (p < 0.01) and the presence or absence of fibromuscular disease (p < 0.002) were the major determinants of late survival with persistent severe hypertension exerting an important but lesser influence. The results of this study indicate that about two-thirds of patients will experience long-term relief of hypertension after operation and that the best long-term survival and blood pressure relief will be obtained in patients less than 50 years of age. Because hypertension in females is better tolerated, younger, male patients appear to have the most to gain from successful renovascular reconstruction. more...
- Published
- 1980
- Full Text
- View/download PDF
43. Membrane vs bubble oxygenator: clinical comparison.
- Author
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Liddicoat JE, Bekassy SM, Beall AC Jr, Glaeser DH, and DeBakey ME
- Subjects
- Adult, Aged, Blood Pressure, Blood Urea Nitrogen, Coronary Artery Bypass, Creatinine blood, Female, Heart Valve Prosthesis, Hemoglobins analysis, Hemostasis, Humans, Male, Middle Aged, Postoperative Complications, Prothrombin analysis, Time Factors, Water-Electrolyte Balance, Cardiopulmonary Bypass, Disposable Equipment, Extracorporeal Circulation, Oxygenators instrumentation, Oxygenators, Membrane instrumentation
- Abstract
Numerous studies have demonstrated the superiority of membrane oxygenators (MO) over the bubble oxygenators (BO) when used for prolonged cardiopulmonary support. However, there is little information available evaluating the MO for routine, short-term cardiopulmonary bypass. In this study the 5MO314 Modulung-Teflo (MO) was compared to 5M30314 Miniprime Variflo (BO). The data of 91 patients (46 MO and 45 BO) were analyzed according to the duration of cardiopulmonary bypass (Group I less than 60 min., Group II 60-90 min. and Group III greater than 90 min.). Hemodynamic parameters, fluid and blood balance, as well as hematologic and blood gas studies were used for comparing the two oxygentors. The hemodynamic parameters were better, and the arterial blood gases were more physilogic with the MO. The postoperative blood loss was significantly less when using the MO. The other measurements documented the stability of the MO. All statements were based on statistical analysis with a DEC PDP-9 computer, using the MIIS language and operating system. Consequently, we are now using this MO for routine cardiopulmonary bypass. more...
- Published
- 1975
- Full Text
- View/download PDF
44. The St. Jude valve prosthesis: analysis of the clinical results in 815 implants and the need for systemic anticoagulation.
- Author
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Myers ML, Lawrie GM, Crawford ES, Howell JF, Morris GC Jr, Glaeser DH, and DeBakey ME
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Anticoagulants adverse effects, Evaluation Studies as Topic, Female, Hemorrhage chemically induced, Humans, Male, Middle Aged, Reoperation, Thromboembolism etiology, Thromboembolism prevention & control, Warfarin therapeutic use, Anticoagulants therapeutic use, Heart Valve Prosthesis adverse effects, Heart Valve Prosthesis mortality
- Abstract
Between July 1979 and December 1984, 785 patients received 815 St. Jude Medical valve prostheses. Valve-related mortality in the follow-up period was due to thromboembolism in seven cases, anticoagulant-related hemorrhage in three and perivalvular leak in two. Freedom from valve-related death or reoperation at 3 years was 96.4% for aortic valve replacement and 98.3% for mitral valve replacement. The overall rate of thromboembolism was 2.6%/patient-year with warfarin, 9.2%/patient-year with antiplatelet medication and 15.6%/patient-year in patients with no anticoagulant therapy. One episode of thrombotic obstruction of a mitral valve, in a patient receiving no anticoagulant therapy, resulted in an occurrence rate of such obstruction of 0.22%/patient-year. Valve replacement with the St. Jude valve produced excellent clinical results, but long-term anticoagulation with warfarin was required to minimize thromboembolic complications. The use of antiplatelet agents alone provided inadequate protection. more...
- Published
- 1989
- Full Text
- View/download PDF
45. Thoracoabdominal aortic aneurysms: preoperative and intraoperative factors determining immediate and long-term results of operations in 605 patients.
- Author
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Crawford ES, Crawford JL, Safi HJ, Coselli JS, Hess KR, Brooks B, Norton HJ, and Glaeser DH
- Subjects
- Adolescent, Adult, Aged, Analysis of Variance, Aorta, Abdominal, Aorta, Thoracic, Aortic Aneurysm mortality, Female, Humans, Intraoperative Complications, Kidney Diseases complications, Male, Middle Aged, Preoperative Care, Prognosis, Aortic Aneurysm surgery
- Abstract
Graft inclusion and vessel reattachment to openings made in the graft were employed in the treatment of 605 patients with thoracoabdominal aortic aneurysms. These patients were divided into four groups on the basis of the extent of aneurysm. Group I consisted of those patients with involvement of most of the descending thoracic and upper abdominal aorta; group II involved most of the descending thoracic aorta and most or all of the abdominal aorta; group III involved the distal descending thoracic aorta and varying segments of abdominal aorta; and group IV involved most or all of the abdominal aorta including the segment from which the visceral vessels arose. The cause of aneurysm formation was medial degenerative disease in 80%, and dissection in 17%; other causes were responsible in the remaining 3%. The median age was 65 years and associated diseases including aneurysms involving other segments, atherosclerotic occlusive disease, heart disease, chronic obstructive pulmonary disease (COPD), hypertension, and renal insufficiency were frequent. The aneurysm was symptomatic in 70% of cases and rupture had occurred in 4% of cases. There were 54 (8.9%) early (30-day) deaths and 151 late deaths; 400 (66%) patients were still alive 3 months to 20 years after operation, including 60% at 5 years. Statistically significant pre- and intraoperative variables by univariate analysis that were predictive of increased risk of early death were advancing age, associated diseases that included COPD, renal artery occlusive disease, atherosclerotic heart disease, renal insufficiency, and long aortic clamp time. Three of these (age, clamp time, and the presence of COPD) retained significance by multivariate analysis. Variables predictive of risk of late death were age, dissection, extent of aneurysm, rupture, heart disease, cerebrovascular disease, COPD, hypertension, and poor renal function. Age, rupture, renal dysfunction, extent of aneurysm, and dissection retained their significance by multivariate analysis. Variables predictive of neurologic disturbances of the lower extremities included rupture, reattachment of intercostal and lumbar arteries, clamp time, dissection, extent and age. Rupture, reattachment of vessels, dissection, and extent of aneurysm retained significance by multivariate analysis. Thus, the risk of this complication was greatest in patients with extensive lesions (group II) with aortic dissection. The greatest risk of renal failure after operation that required dialysis was in patients who had impaired renal function before operation. Methods employed did not prevent these complications. more...
- Published
- 1986
- Full Text
- View/download PDF
46. A semiautomated technique for the rapid determination of left ventricular volume from left ventricular cineangiograms.
- Author
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Cole JS, Brown DD, and Glaeser DH
- Subjects
- Adult, Automation, Computers, Female, Heart Ventricles, Humans, Information Systems, Male, Medical Laboratory Science, Methods, Middle Aged, Blood Volume Determination, Cineangiography
- Published
- 1974
- Full Text
- View/download PDF
47. Patterns of atherosclerosis and their surgical significance.
- Author
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DeBakey ME, Lawrie GM, and Glaeser DH
- Subjects
- Analysis of Variance, Angioplasty, Balloon, Aorta, Abdominal pathology, Aorta, Thoracic pathology, Arteriosclerosis surgery, Arteriosclerosis therapy, Coronary Artery Bypass, Coronary Vessels pathology, Endarterectomy, Female, Follow-Up Studies, Humans, Male, Recurrence, Retrospective Studies, Arteriosclerosis classification
- Abstract
The records of 13,827 patients admitted on one or more occasions to The Methodist Hospital in Houston on the service of the senior author for the treatment of arterial atherosclerotic occlusive disease from 1948 to 1983 were analyzed. The data derived from this analysis are believed to support the concept that atherosclerotic occlusive disease tends to assume characteristic patterns that may be classified, by predominant site or distribution of the disease, into five major categories: (I) the coronary arterial bed, (II) the major branches of the aortic arch, (III) the visceral arterial branches of the abdominal aorta, (IV) the terminal abdominal aorta and its major branches, and (V) a combination of two or more of these categories occurring simultaneously. Category IV had the highest proportion of patients (about two-fifths), Category I the second highest (almost one-third), and Category III had the lowest percentage (3%). Atherosclerotic occlusive disease in all categories tends to be well localized and usually occurs in the proximal or midproximal portions of the arterial bed. Such lesions are amenable to effective surgical treatment directed toward restoration of normal circulation. Less commonly, however, the occlusive disease in all categories occurs predominantly in the distal portions of the arterial bed, and such lesions are usually not amenable to effective surgical treatment. Patients in Categories I and III were significantly younger than those in the other categories and, although males predominated in all categories, Categories II and III contained significantly more female patients than did the other categories. In general, however, female patients behaved like male patients in virtually all aspects of the study. The rates of progression of the disease may be classified into: rapid (0 to 36 months), moderate (37 to 120 months), and slow (more than 120 months). The rapid and moderate rates of progression occurred most frequently in Categories II and IV, and the moderate and slow rates occurred most frequently in Category I. The possibility for development of recurrence or progression of disease in the same category and in a new category was significantly greater in younger patients. The patient's sex had no significant influence in this regard. Among the various categories, patients in Category IV had the highest incidence of development of disease in a new category, and Category I had the lowest incidence. Patients originally in Category II had a somewhat greater tendency to development of disease in Category IV, and patients originally in Category IV, for development of disease in Category II.(ABSTRACT TRUNCATED AT 400 WORDS) more...
- Published
- 1985
- Full Text
- View/download PDF
48. Late repair of coarctation of the descending thoracic aorta in 190 patients. Results up to 30 years after operation.
- Author
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Lawrie GM, DeBakey ME, Morris GC Jr, Crawford ES, Wagner WF, and Glaeser DH
- Subjects
- Adolescent, Adult, Age Factors, Aortic Coarctation physiopathology, Blood Pressure, Child, Child, Preschool, Female, Follow-Up Studies, Humans, Hypertension complications, Infant, Male, Middle Aged, Polyethylene Terephthalates, Postoperative Complications, Aortic Coarctation surgery, Blood Vessel Prosthesis
- Abstract
Over a 30-year period, 190 consecutive patients had repair of coarctation of the descending thoracic aorta at a mean age of 25 years (range, 1 to 60 years); 130 were male. Median preoperative blood pressure (BP) was as follows: systolic, 160 mm Hg (range, 94 to 300 mm Hg) and diastolic, 90 mm Hg (range, 50 to 160 mm Hg). Dacron grafts were used in 64.7% of patients. Follow-up was obtained at a mean interval of 84.9 months, range, one to 360 months. Survival status was established for 86.1% (163/190) of patients. Postoperatively, the median BP was 133 mm Hg systolic (range, 90 to 195 mm Hg) and 80 mm Hg diastolic (range, 50 to 120 mm Hg). Overall, 80% of patients were either normotensive or had mild hypertension after operation. The best BP response and late survival were in patients operated on under 13 years of age. This study further confirms that early operation (below 5 years of age) is desirable. However, contrary to some previous reports, patients operated on as adolescents, despite some mild residual hypertension, had an excellent long-term prognosis. Patients over 21 years of age at operation had a high rate of persistent hypertension and experienced other serious cardiovascular complications. more...
- Published
- 1981
- Full Text
- View/download PDF
49. Aortoiliac occlusive disease: factors influencing survival and function following reconstructive operation over a twenty-five-year period.
- Author
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Crawford ES, Bomberger RA, Glaeser DH, Saleh SA, and Russell WL
- Subjects
- Adult, Aged, Amputation, Surgical, Arteriosclerosis mortality, Arteriosclerosis physiopathology, Blood Vessel Prosthesis, Endarterectomy, Female, Follow-Up Studies, Humans, Intermittent Claudication surgery, Leg blood supply, Male, Middle Aged, Pulse, Time Factors, Aortic Diseases surgery, Arteriosclerosis surgery, Iliac Artery surgery
- Abstract
During a period of slightly over 25 years, 949 new patients with aortoiliac atherosclerotic occlusive disease--409 (43%) with associated distal disease--were submitted to various reconstructive operations for claudication in 719 and rest ischemic problems in 230 patients. The ages ranged from 21 to 91 years with a medial age of 59. Men outnumbered women 2.5 to 1. Associated diseases were present in 695 (75%); heart disease and diabetes were most common. The mortality rate from operation--50% of which was from heart disease--8% in first 5 years and 3% during the last 15 years. Good function, i.e., restoration of femoral pulses, leg salvage, and relief of symptoms, was achieved in 95% of cases early after treatment. Early results were best in patients with claudication and those without associated distal disease. The long-term survival rates were significant--50%, 30%, and 15% at 10, 15, and 20 years, respectively--and successful function was maintained in survivors in 79%, 70%, and 56% at the same intervals. Amputation was performed in only 23 (3%) patients with claudication and 33 (14%) with rest ischemia during the period of study. Survival, functional results, and incidence of amputation varied with the numerous factors described in detail herein. more...
- Published
- 1981
50. Pacemaker follow-up: its role in the detection and correction of pacemaker system malfunction.
- Author
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Griffin JC, Schuenemeyer TD, Hess KR, Glaeser D, Anderson BJ, Romans E, Jenkins MA, and Nielsen AP
- Subjects
- Equipment Failure, Follow-Up Studies, Humans, Outpatient Clinics, Hospital, Risk, Time Factors, Pacemaker, Artificial
- Abstract
The goal of pacemaker follow-up is not only to detect battery depletion but also to detect all malfunctions of the pacing system and, when possible, to correct such problems using programming. During one year, we discovered 61 such malfunctions in a clinic of 1065 patients (5.7%). These were more frequent in the first year (7.7%) than in the third to fifth years of follow-up (range 3.1-4.8%). The incidence rose again in the sixth and subsequent years (7-7.7%). Despite a significant occurrence of malfunctions (5.2%) among multiprogrammable pacemakers, the necessity for operative intervention for their correction was low (1.2%). Sensing problems were the most common (57%) and the most likely to be corrected by reprogramming (85%); problems involving loss of capture were less likely to be corrected by programming (38.5%). Battery depletion accounted for only 18% of malfunctions, occurring earliest in the forty-third month of follow-up. Pulse generator longevity of those devices reaching end of battery life during the study period was 68.6 +/- 16.7 months (mean + SD). We conclude that specialized pacemaker follow-up continues to be necessary despite improved pulse generator reliability and longevity. Indeed, with reprogramming, it presently plays an even more important role than in the past. Follow-up should be oriented not only to the detection of battery depletion but also toward a comprehensive surveillance of pacemaker system function. more...
- Published
- 1986
- Full Text
- View/download PDF
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