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9 results on '"Gkizas, Vasileios"'

4. Ticagrelor vs clopidogrel followed by ticagrelor re-loading in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: A randomized, pharmacodynamic comparison

Author

Alexopoulos, Dimitrios, primary, Kontoprias, Kosmas, additional, Gkizas, Vasileios, additional, Karanikas, Stavros, additional, Ziakas, Antonios, additional, Barampoutis, Nikolaos, additional, Tsigkas, Grigorios, additional, Koutsogiannis, Nikolaos, additional, Davlouros, Periklis, additional, Patsilinakos, Sotirios, additional, Karvounis, Haralambos, additional, Hahalis, George, additional, and Xanthopoulou, Ioanna, additional

Published
2016
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6. Crushed Versus Integral Tablets of Ticagrelor in ST-Segment Elevation Myocardial Infarction Patients: A Randomized Pharmacokinetic/Pharmacodynamic Study

Author

Alexopoulos, Dimitrios, primary, Barampoutis, Nikolaos, additional, Gkizas, Vasileios, additional, Vogiatzi, Chrysoula, additional, Tsigkas, Grigorios, additional, Koutsogiannis, Nikolaos, additional, Davlouros, Periklis, additional, Hahalis, George, additional, Nylander, Sven, additional, Parodi, Guido, additional, and Xanthopoulou, Ioanna, additional

Published
2015
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7. Diagnostic Accuracy of Electrocardiographic ST-Segment Depression in Patients With Rapid Atrial Fibrillation for the Prediction of Coronary Artery Disease

Author

Tsigkas, Grigorios, primary, Kopsida, Georgia, additional, Xanthopoulou, Ioanna, additional, Davlouros, Periklis, additional, Koutsogiannis, Nikolaos, additional, Makris, Georgios, additional, Theodoropoulos, Konstantinos, additional, Kassimis, George, additional, Gkizas, Vasileios, additional, Hahalis, George, additional, and Alexopoulos, Dimitrios, additional

Published
2014
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9. Calcium Homeostasis and Kinetics in Heart Failure.

Author

Davlouros PA, Gkizas V, Vogiatzi C, Giannopoulos G, Alexopoulos D, and Deftereos S

Subjects
Animals, Calcium-Binding Proteins metabolism, Cardiovascular Agents pharmacology, Energy Metabolism, Heart Failure drug therapy, Homeostasis, Humans, Kinetics, Molecular Targeted Therapy, Myocytes, Cardiac drug effects, Myocytes, Cardiac metabolism, Ryanodine Receptor Calcium Release Channel metabolism, Sarcoplasmic Reticulum Calcium-Transporting ATPases metabolism, Calcium metabolism, Heart Failure metabolism
Abstract

Although HF has multiple causes amongst which coronary artery disease, hypertension and non-ischemic dilated cardiomyopathy are the most common, it results in the same final common pathway of neurohormonal activation and multiorgan dysfunction in the context of a salt-avid state. Contemporary pharmacologic HF therapy targets neurohormonal activation at multiple levels with β- blockers, angiotensin converting enzyme inhibitors, and aldosterone inhibitors, aiming in reversing both its systemic consequences, and the adverse heart remodeling, however is frequently hampered by side effects of the drugs, limiting its benefit. During the last 40 years studies of the gross and molecular aspects of the pathophysiology of HF convincingly converge to the conclusion that deranged calcium (Ca(2+)) handling in the cardiomyocytes plays a cardinal role in HF initiation and progression. The delicate and precise regulation of Ca(2+) cycling i.e. movement into and out of the cell, as well as into and out of the sarcoplasmic reticulum (SR), is finely tuned by numerous macromolecular proteins and regulatory processes like phosphorylation and dephosphorylation, and is severely deranged in HF. The common denominator in this scenario is Ca(2+) depletion of the SR, however loading of cardiomyocytes with Ca(2+) as a result of classic inotropic therapy has proved to be detrimental in the long term. Therefore, the mediator and/or regulatory components of the Ca(2+) cycling apparatus have been the focus of extensive research involving targeted pharmacologic and gene interventions aiming to a restoration of Ca(2+) cycling processes, thus improving inotropy and lucitropy in a more "physiologic" way in the failing myocardium.

Published
2016
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