Author: "Gjørup, I" - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"Gjørup, I"' showing total 49 results

Start Over Author "Gjørup, I"

49 results on '"Gjørup, I"'

1. Twenty-year Survey of the Epidemiology of Hepatitis B in Denmark: Effect of Immigration

Author: Gjørup, I. E., Smith, E., Borgwardt, L., and Skinhøj, P.
Published: 2003

2. Epidemiology and clinical features of vivax malaria imported to Europe: Sentinel surveillance data from TropNetEurop

Author: Malvy DJM, Kotlowski A, Iversen J, Knobloch J, Kapaun A, Kollaritsch H, Hatz C, Holthoff-Stich ML, Laferl H, Myrvang B, Schmid ML, Puente S, Hellgren U, Bisoffi Z, Lopez-Velez R, Matteelli A, McWhinney P, Björkman A, Clerinx J, Behrens RH, Gjørup I, Beran J, Schunk M, Zoller T, Probst M, Gascon J, Jelinek T, Mühlberger N, Kern P, Fry G, Siikamaki H, Schulze MH, Soula G, Paul M, Prat J Gómez i, Lehmann V, Bouchaud O, Cunha S da, Atouguia J, and Boecken G
Subjects: Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216
Abstract: Abstract Background Plasmodium vivax is the second most common species among malaria patients diagnosed in Europe, but epidemiological and clinical data on imported P. vivax malaria are limited. The TropNetEurop surveillance network has monitored the importation of vivax malaria into Europe since 1999. Objectives To present epidemiological and clinical data on imported P. vivax malaria collected at European level. Material and methods Data of primary cases of P. vivax malaria reported between January 1999 and September 2003 were analysed, focusing on disease frequency, patient characteristics, place of infection, course of disease, treatment and differences between network-member countries. Results Within the surveillance period 4,801 cases of imported malaria were reported. 618 (12.9%) were attributed to P. vivax. European travellers and immigrants were the largest patient groups, but their proportion varied among the reporting countries. The main regions of infection in descending order were the Indian subcontinent, Indonesia, South America and Western and Eastern Africa, as a group accounting for more than 60% of the cases. Regular use of malaria chemoprophylaxis was reported by 118 patients. With 86 (inter-quartile range 41–158) versus 31 days (inter-quartile range 4–133) the median symptom onset was significantly delayed in patients with chemoprophylaxis (p < 0.0001). Common complaints were fever, headache, fatigue, and musculo-skeletal symptoms. All patients survived and severe clinical complications were rare. Hospitalization was provided for 60% and primaquine treatment administered to 83.8% of the patients, but frequencies varied strongly among reporting countries. Conclusions TropNetEurop data can contribute to the harmonization of European treatment policies.
Published: 2004
Full Text: View/download PDF

3. Age as a Risk Factor for Severe Manifestations and Fatal Outcome of Falciparum Malaria in European Patients: Observations from TropNetEurop and SIMPID Surveillance Data

Author: Mühlberger, N., Jelinek, T., Behrens, R. H., Gjørup, I., Coulaud, J. P., Clerinx, J., Puente, S., Burchard, G., Gascon, J., Grobusch, M. P., Weitzel, T., Zoller, T., Kollaritsch, H., Beran, J., Iversen, J., Hatz, C., Schmid, M. L., Björkman, A., Fleischer, K., Bisoffi, Z., Guggemos, W., Knobloch, J., Matteelli, A., Schulze, M. H., Laferl, H., Kapaun, A., McWhinney, P., Lopez-Velez, R., Fôtkenheuer, G., Kern, P., Zieger, B. W., Kotlowski, A., Fry, G., Cuadros, J., Myrvang, B., Mühlberger, N., Jelinek, T., Behrens, R. H., Gjørup, I., Coulaud, J. P., Clerinx, J., Puente, S., Burchard, G., Gascon, J., Grobusch, M. P., Weitzel, T., Zoller, T., Kollaritsch, H., Beran, J., Iversen, J., Hatz, C., Schmid, M. L., Björkman, A., Fleischer, K., Bisoffi, Z., Guggemos, W., Knobloch, J., Matteelli, A., Schulze, M. H., Laferl, H., Kapaun, A., McWhinney, P., Lopez-Velez, R., Fôtkenheuer, G., Kern, P., Zieger, B. W., Kotlowski, A., Fry, G., Cuadros, J., and Myrvang, B.
Abstract: Previous studies have indicated that age is a risk factor for severe falciparum malaria in nonimmune patients. The objectives of this study were to reevaluate previous findings with a larger sample and to find out how strongly clinical outcomes for elderly patients differ from those for younger patients. Results of adjusted analyses indicated that the risks of death due to falciparum malaria, of experiencing cerebral or severe disease in general, and of hospitalization increased significantly with each decade of life. The case-fatality rate was almost 6 times greater among elderly patients than among younger patients, and cerebral complications occurred 3 times more often among elderly patients. Antimalarial chemoprophylaxis was significantly associated with a lower case-fatality rate and a lower frequency of cerebral complications. Women were more susceptible to cerebral complications than were men. Our study provides evidence that falciparum malaria is more serious in older patients and demonstrates that clinical surveillance networks are capable of providing quality data for investigation of rare events or diseases
Published: 2017

4. Epidemiology and Clinical Features of Imported Dengue Fever in Europe: Sentinel Surveillance Data from TropNetEurop

Author: Jelinek, T., Mühlberger, N., Harms, G., Corachán, M., Grobusch, M. P., Knobloch, J., Bronner, U., Laferl, H., Kapaun, A., Bisoffi, Z., Clerinx, J., Puente, S., Fry, G., Schulze, M., Hellgren, U., Gjørup, I., Chalupa, P., Hatz, C., Matteelli, A., Schmid, M., Nielsen, L. N., da Cunha, S., Atouguia, J., Myrvang, B., Fleischer, K., Jelinek, T., Mühlberger, N., Harms, G., Corachán, M., Grobusch, M. P., Knobloch, J., Bronner, U., Laferl, H., Kapaun, A., Bisoffi, Z., Clerinx, J., Puente, S., Fry, G., Schulze, M., Hellgren, U., Gjørup, I., Chalupa, P., Hatz, C., Matteelli, A., Schmid, M., Nielsen, L. N., da Cunha, S., Atouguia, J., Myrvang, B., and Fleischer, K.
Abstract: Travelers have the potential both to acquire and to spread dengue virus infection. The incidence of dengue fever (DF) among European travelers certainly is underestimated, because few centers use standardized diagnostic procedures for febrile patients. In addition, DF is currently not reported in most European public health systems. Surveillance has commenced within the framework of a European Network on Imported Infectious Disease Surveillance (TropNetEurop) to gain information on the quantity and severity of cases of dengue imported into Europe. Descriptions of 294 patients with DF were analyzed for epidemiological information and clinical features. By far the most infections were imported from Asia, which suggests a high risk of DF for travelers to that region. Dengue hemorrhagic fever occurred in 7 patients (2.4%) all of whom recovered. Data reported by member sites of the TropNetEurop can contribute to understanding the epidemiology and clinical characteristics of imported DF
Published: 2017

5. Imported Falciparum Malaria in Europe: Sentinel Surveillance Data from the European Network on Surveillance of Imported Infectious Diseases

Author: Jelinek, T., Schulte, C., Behrens, R., Grobusch, M. P., Coulaud, J. P., Bisoffi, Z., Matteelli, A., Clerinx, J., Corachán, M., Puente, S., Gjørup, I., Harms, G., Kollaritsch, H., Kotlowski, A., Björkmann, A., Delmont, J. P., Knobloch, J., Nielsen, L. N., Cuadros, J., Hatz, C., Beran, J., Schmid, M. L., Schulze, M., Lopez-Velez, R., Fleischer, K., Kapaun, A., McWhinney, P., Kern, P., Atougia, J., Fry, G., da Cunha, S., Boecken, G., Jelinek, T., Schulte, C., Behrens, R., Grobusch, M. P., Coulaud, J. P., Bisoffi, Z., Matteelli, A., Clerinx, J., Corachán, M., Puente, S., Gjørup, I., Harms, G., Kollaritsch, H., Kotlowski, A., Björkmann, A., Delmont, J. P., Knobloch, J., Nielsen, L. N., Cuadros, J., Hatz, C., Beran, J., Schmid, M. L., Schulze, M., Lopez-Velez, R., Fleischer, K., Kapaun, A., McWhinney, P., Kern, P., Atougia, J., Fry, G., da Cunha, S., and Boecken, G.
Abstract: Malaria continues to have a high morbidity rate associated among European travelers. Thorough recording of epidemiological and clinical aspects of imported malaria has been helpful in the detection of new outbreaks and areas of developing drug resistance. Sentinel surveillance of data collected prospectively since 1999 has begun within TropNetEurop, a European network focusing on imported infectious diseases. TropNetEurop appears to cover ∼10% of all patients with malaria seen in Europe. Reports of 1659 immigrants and European patients with Plasmodium falciparum malaria were analyzed for epidemiological information and data on clinical features. Regional data were quite diverse, reflecting local patterns of immigration and international travel. By far, the most infections were imported from West Africa. Europeans had more clinical complications; consequently, all deaths occurred in this group. Compared with European standards, the mortality rate was low (0.6% in Europeans). Data from TropNetEurop member sites can contribute to our understanding of the epidemiological and clinical findings regarding imported falciparum malaria
Published: 2017

6. Does short-term virologic failure translate to clinical events in antiretroviral-naïve patients initiating antiretroviral therapy in clinical practice?

Author: Antiretroviral Therapy Cohort Collaboration, Mugavero, Mj, May, M, Harris, R, Saag, Ms, Costagliola, D, Egger, M, Phillips, A, Günthard, Hf, Dabis, F, Hogg, R, de Wolf, F, Fatkenheuer, G, Gill, Mj, Justice, A, D'Arminio Monforte, A, Lampe, F, Miró, Jm, Staszewski, S, Collaborators: Casabona J, Sterne J. A., Geneviè, C, del Amo, J, Fätkenheuer, G, Gill, J, Guest, J, Kitahata, M, Ledergerber, B, Mocroft, A, Reiss, P, Saag, M, Sterne, J, Sterne, Ja, Abgrall, S, Barin, F, Bentata, M, Billaud, E, Boué, F, Burty, C, Cabié, A, Cotte, L, De Truchis, P, Duval, X, Duvivier, C, Enel, P, Fredouille Heripret, L, Gasnault, J, Gaud, C, Gilquin, J, Grabar, S, Katlama, C, Khuong, Ma, Lang, Jm, Lascaux, As, Launay, O, Mahamat, A, Mary Krause, M, Matheron, S, Meynard, Jl, Pavie, J, Pialoux, G, Pilorgé, F, Poizot Martin, I, Pradier, C, Reynes, J, Rouveix, E, Simon, A, Tattevin, P, Tissot Dupon, H, Viard, Jp, Viget, N, Pariente Khayat, A, Salomon, V, Jacquemet, N, Rivet, A, Abgral, S, Guiguet, M, Kousignian, I, Lanoy, E, Lièvre, L, Potard, V, Selinger Leneman, H, Bouvet, E, Crickx, B, Ecobichon, Jl, Leport, C, Picard Dahan, C, Yeni, P, Tisne Dessus, D, Weiss, L, Salmon, D, Sicard, D, Auperin, I, Roudière, L, Fior, R, Delfraissy, Jf, Goujard, C, Jung, C, Lesprit, P, Desplanque, N, Meyohas, Mc, Picard, O, Cadranel, J, Mayaud, C, Bricaire, F, Herson, S, Clauvel, Jp, Decazes, Jm, Gerard, L, Molina, Jm, Diemer, M, Sellier, P, Berthé, H, Dupont, C, Chandemerle, C, Mortier, E, de Truchis, P, Honoré, P, Jeantils, V, Tassi, S, Mechali, D, Taverne, B, Gourdon, F, Laurichesse, H, Fresard, A, Lucht, F, Eglinger, P, Faller, Jp, Bazin, C, Verdon, R, Boibieux, A, Peyramond, D, Livroze, Jm, Touraine, Jl, Trepo, C, Ravaux, I, Tissot Dupont, H, Delmont, Jp, Moreau, J, Gastaut, Ja, Retornaz, F, Soubeyrand, J, Allegre, T, Blanc, Pa, Galinier, A, Ruiz, Jm, Lepeu, G, Granet Brunello, P, Esterni, Jp, Pelissier, L, Cohen Valensi, R, Nezri, M, Chadapaud, S, Laffeuillade, A, Laffeuillade, J, May, T, Rabaud, C, Raffi, F, Pugliese, P, Arvieux, C, Michelet, C, Borsa Lebas, F, Caron, F, Fraisse, P, Rey, D, Arlet Suau, E, Cuzin, L, Massip, P, Thiercelin Legrand MF, Yasdanpanah, Y, Pradinaud, R, Sobesky, M, Contant, M, Montroni, M, Scalise, G, Braschi, Mc, Riva, A, Tirelli, U, Cinelli, R, Pastore, G, Ladisa, N, Suter, F, Arici, C, Chiodo, F, Colangeli, V, Fiorini, C, Carosi, Giampiero, Cristini, G, Torti, Carlo, Minardi, C, Bertelli, D, Quirino, T, Manconi, Pe, Piano, P, Cosco, L, Scerbo, A, Vecchiet, J, D'Alessandro, M, Santoro, D, Pusterla, L, Carnevale, G, Zoncada, A, Viganò, P, Mena, M, Ghinelli, F, Sighinolfi, L, Leoncini, F, Mazzotta, F, Pozzi, M, Lo Caputo, S, Angarano, G, Grisorio, B, Saracino, A, Ferrara, S, Grima, P, Grima, F, Pagano, G, Cassola, G, Alessandrini, A, Piscopo, R, Toti, M, Trezzi, M, Soscia, F, Tacconi, L, Orani, A, Perini, P, Scasso, A, Vincenti, A, Chiodera, F, Castelli, P, Scalzini, A, Palvarini, L, Moroni, M, Lazzarin, A, Rizzardini, G, d'Arminio Monforte, A, Galli, A, Merli, S, Pastecchia, C, Moioli, Mc, Esposito, R, Mussini, C, Abresci, N, Chirianni, A, Izzo, Cm, Piazza, M, De Marco, M, Viglietti, R, Manzillo, E, Nappa, S, Colomba, A, Abbadessa, V, Prestileo, T, Mancuso, S, Ferrari, C, Pizzaferri, P, Filice, G, Minoli, L, Bruno, R, Novati, S, Baldelli, F, Tinca, M, Petrelli, E, Cioppi, A, Cioppi, F, Ruggieri, A, Menichetti, F, Martinelli, C, De Stefano, C, La Gala, A, Ballardini, G, Rizzo, E, Magnani, G, Ursitti, Ma, Arlotti, M, Ortolani, P, Cauda, R, Dianzani, F, Ippolito, G, Antinori, A, Antonucci, G, Ciardi, M, Narciso, P, Petrosillo, N, Vullo, V, De Luca, A, Zaccarelli, M, Acinapura, R, De Longis, P, Brandi, A, Trotta, Mp, Noto, P, Lichtne, M, Capobianch, Mr, Carletti, F, Girardi, E, Pezzotti, P, Rezza, G, Mura, Ms, Mannazzu, M, Caramello, P, Di Perri, G, Sciandra, M, Orofino, Gc, Grossi, Pa, Basilico, C, Poggio, A, Bottari, G, Raise, E, Ebo, F, Pellizzer, G, Buonfrate, D, Resta, F, Loso, K, Cozzi Lepri, A, Battegay, M, Bernasconi, E, Böni, J, Bucher, Hc, Bürgisser, P, Calmy, A, Cattacin, S, Cavassini, M, Dubs, R, Elzi, L, Fischer, M, Flepp, M, Fontana, A, Francioli, P, Furrer, H, Fux, C, Gorgievski, M, Günthard, H, Hirsch, H, Hirschel, B, Hösli, I, Kahlert, Ch, Kaiser, L, Karrer, U, Kind, C, Klimkait, T, Martinetti, G, Martinez, B, Martinez, N, Nadal, D, Opravil, M, Paccaud, F, Pantaleo, G, Rauch, A, Regenass, S, Rickenbach, M, Rudin, C, Schmid, P, Schultze, D, Schüpbach, J, Speck, R, Taffé, P, Telenti, A, Trkola, A, Vernazza, P, Weber, R, Yerly, S, Gras, La, van Sighem AI, Smit, C, Prins, Jm, Branger, J, Eeftinck Schattenkerk JK, Gisolf, J, Godfried, Mh, Lange, Jm, Lettinga, Kd, van der Meer JT, Nellen, Fj, van der Poll, T, Ruys, Ta, Steingrover, R, Vermeulen, Jn, Vrouenraets, Sm, van Vugt, M, Wit, Fw, Kuijpers, Tw, Pajkrt, D, Scherpbier, Hj, van Eeden, A, Brinkman, K, van den Berk GE, Blok, Wl, Frissen, Ph, Roos, Jc, Schouten, We, Mulder, Jw, van Gorp EC, Wagenaar, J, Veenstra, J, Danner, Sa, Van Agtmael MA, Claessen, Fa, Perenboom, Rm, Rijkeboer, A, van Vonderen MG, Richter, C, van der Berg, J, Vriesendorp, R, Jeurissen, Fj, Kauffmann, Rh, Pogány, K, Bravenboer, B, Sprenger, Hg, van Assen, S, van Leeuwen JT, Doedens, R, Scholvinck, Eh, ten Kate RW, Soetekouw, R, van Houte, D, Polée, Mb, Kroon, Fp, van den Broek PJ, van Dissel JT, Schippers, Ef, Schreij, G, van der Geest, S, Lowe, S, Verbon, A, Koopmans, Pp, Van Crevel, R, de Groot, R, Keuter, M, Post, F, van der Ven AJ, Warris, A, van der Ende ME, Gyssens, Ic, van der Feltz, M, Nouwen, Jl, Rijnders, Bj, de Vries TE, Driessen, G, van der Flier, M, Hartwig, Ng, Juttman, Jr, van Kasteren ME, Van de Heul, C, Hoepelman, Im, Schneider, Mm, Bonten, Mj, Borleffs, Jc, Ellerbroek, Pm, Jaspers, Ca, Mudrikove, T, Schurink, Ca, Gisolf, Eh, Geelen, Sp, Wolfs, Tf, Faber, T, Tanis, Aa, Groeneveld, Ph, den Hollander JG, Duits, Aj, Winkel, K, Back, Nk, Bakker, Me, Berkhout, B, Jurriaans, S, Zaaijer, Hl, Cuijpers, T, Rietra, Pj, Roozendaal, Kj, Pauw, W, van Zanten AP, Smits, Ph, von Blomberg BM, Savelkoul, P, Pettersson, A, Swanink, Cm, Franck, Pf, Lampe, As, Jansen, Cl, Hendriks, R, Benne, Ca, Veenendaal, D, Storm, H, Weel, J, van Zeijl JH, Kroes, Ac, Claas, Hc, Bruggeman, Ca, Goossens, Vj, Galama, Jm, Melchers, Wj, Poort, Ya, Doornum, Gj, Niesters, Mg, Osterhaus, Ad, Schutten, M, Buiting, Ag, Swaans, Ca, Boucher, Ca, Schuurman, R, Boel, E, Jansz, Af, Veldkamp, A, Beijnen, Jh, Huitema, Ad, Burger, Dm, Hugen, Pw, van Kan HJ, Losso, M, Duran, A, Vetter, N, Karpov, I, Vassilenko, A, Clumeck, N, De Wit, S, Poll, B, Colebunders, R, Machala, L, Rozsypal, H, Sedlacek, D, Nielsen, J, Lundgren, J, Benfield, T, Kirk, O, Gerstoft, J, Katzenstein, T, Hansen, Ab, Skinhøj, P, Pedersen, C, Zilmer, K, Girard, Pm, Saint Marc, T, Vanhems, P, Dietrich, M, Manegold, C, van Lunzen, J, Stellbrink, Hj, Staszewsk, S, Bickel, M, Goebel, Fd, Rockstroh, J, Schmidt, R, Kosmidis, J, Gargalianos, P, Sambatakou, H, Perdios, J, Panos, G, Filandras, A, Karabatsaki, E, Banhegyi, D, Mulcahy, F, Yust, I, Turner, D, Burke, M, Pollack, S, Hassoun, G, Sthoeger, Z, Maayan, S, Chiesi, A, Borghi, R, Pristera, R, Mazzott, F, Gabbuti, A, Vullo, Lichtner, M, Montesarchio, E, Iacomi, F, Finazzi, R, Viksna, L, Chaplinskas, S, Hemmer, R, Staub, T, Bruun, J, Maeland, A, Ormaasen, V, Knysz, B, Gasiorowski, J, Horban, A, Prokopowicz, D, Wiercinska Drapalo, A, Boron Kaczmarska, A, Pynka, M, Beniowski, M, Mularska, E, Trocha, H, Antunes, F, Valadas, E, Mansinho, K, Matez, F, Duiculescu, D, Babes, V, Streinu Cercel, A, Vinogradova, E, Rakhmanova, A, Jevtovic, D, Mokrás, M, Staneková, D, González Lahoz, J, Sánchez Conde, M, García Benayas, T, Martin Carbonero, L, Soriano, V, Clotet, B, Jou, A, Conejero, J, Tural, C, Gatell, Jm, Blaxhult, A, Karlsson, A, Pehrson, P, Soravia Dunand, V, Kravchenko, E, Chentsova, N, Barton, S, Johnson, Am, Mercey, D, Johnson, Ma, Murphy, M, Weber, J, Scullard, G, Fisher, M, Brettle, R, Loveday, C, Gatell, J, Johnson, A, Vella, S, Gjørup, I, Friis Moeller, N, Bannister, W, Mollerup, D, Podlevkareva, D, Holkmann Olsen, C, Kjaer, J, Raffanti, S, Dieterch, D, Becker, S, Scarsella, A, Fusco, G, Most, B, Balu, R, Rana, R, Beckerman, R, Ising, T, Fusco, J, Irek, R, Johnson, B, Hirani, A, Dejesus, E, Pierone, G, Lackey, P, Irek, C, Burdick, J, Leon, S, Arch, J, Helm, Eb, Carlebach, A, Müller, A, Haberl, A, Nisius, G, Lennemann, T, Stephan, C, Mösch, M, Gute, P, Locher, L, Lutz, T, Klauke, S, Knecht, G, Khaykin, P, Doerr, Hw, Stürmer, M, Babacan, E, von Hentig, N, Beylot, J, Chêne, G, Dupon, M, Longy Boursier, M, Pellegrin, Jl, Ragnaud, Jm, Salamon, R, Thiébaut, R, Lewden, C, Lawson Ayayi, S, Mercié, P, Moreau, Jf, Morlat, P, Bernard, N, Lacoste, D, Malvy, D, Neau, D, Blaizeau, Mj, Decoin, M, Delveaux, S, Hannapier, C, Labarrère, S, Lavignolle Aurillac, V, Uwamaliya Nziyumvira, B, Palmer, G, Touchard, D, Balestre, E, Alioum, A, Jacqmin Gadda, H, Bonarek, M, Bonnet, F, Coadou, B, Gellie, P, Nouts, C, Bocquentin, F, Dutronc, H, Lafarie, S, Aslan, A, Pistonne, T, Thibaut, P, Vatan, R, Chambon, D, De La Taille, C, Cazorla, C, Ocho, A, Viallard, Jf, Caubet, O, Cipriano, C, Lazaro, E, Couzigou, P, Castera, L, Fleury, H, Lafon, Me, Masquelier, B, Pellegrin, I, Breilh, D, Blanco, P, Loste, P, Caunègre, L, Bonna, F, Farbos, S, Ferrand, M, Ceccaldi, J, Tchamgoué, S, De Witte, S, Buy, E, Akagi, L, Brandson, E, Druyts, E, Gataric, Kf, Harrigan, Pr, Harris, M, Hayden, A, Lima, V, Montaner, J, Moore, D, Wood, E, Yip, B, Zhang, W, Bhagani, S, Byrne, P, Carroll, A, Cuthbertson, Z, Dunleavy, A, Geretti, Am, Heelan, B, Johnson, M, Kinloch de Loes, S, Lipman, M, Madge, S, Marshall, N, Nair, D, Nebbia, G, Prinz, B, Swaden, L, Tyrer, M, Youle, M, Chaloner, C, Grabowska, H, Holloway, J, Puradiredja, J, Ransom, D, Tsintas, R, Bansi, L, Fox, Z, Harris, E, Hill, T, Lodwick, R, Reekie, J, Sabin, C, Smith, C, Amoah, E, Booth, C, Clewley, G, Garcia Diaz, A, Gregory, B, Labbett, W, Tahami, F, Thomas, M, Read, R, Krentz, H, Beckthold, B, Faetkenheuer, G, Casabona, J, Miró, Jl, Alquézar, A, Esteve, A, Podzamczer, D, Murillas, J, Romero, A, Agustí, C, Agüero, F, Ferrer, E, Riera, M, Segura, F, Segura, G, Force, L, Vilaró, J, Masabeu, A, García, I, Guadarrama, M, Montoliu, A, Ortega, N, Lazzari, E, Puchol, E, Sanchez, M, Blanco, Jl, Garcia Alcaide, F, Martinez, E, Mallolas, J, López Dieguez, M, García Goez JF, Sirera, G, Romeu, J, Negredo, E, Miranda, C, Capitan, Mc, Olmo, M, Barragan, P, Saumoy, M, Bolaof, F, Cabellos, C, Peña, C, Sala, M, Cervantes, M, Amengual, Mj, Navarro, M, Penelo, E, Barrufet, P, Willig, Jh, Raper, Jl, Allison, Jj, Kempf, Mc, Schumacher, Je, Wes, Ao, Lin, Hy, Pisu, M, Moneyham, L, Vance, D, Bachmann, L, Davies, Sl, Berner, E, Acosta, E, King, J, Savage, K, Nevin, C, Walton, Fb, Marler, Ml, Lawrence, S, Files Kennedy, B, Batey, Ds, Patil, Ma, Patil, U, Varshney, M, Gibson, E, Guzman, A, Rinehart, D, Justice, Ac, Fiellin, Da, Bryant, K, Rimland, D, Jones Taylor, C, Oursler, Ka, Titanji, R, Brown, S, Garrison, S, Rodriguez Barradas, M, Masozera, N, Goetz, M, Leaf, D, Simberkoff, M, Blumenthal, D, Leung, J, Butt, A, Hoffman, E, Gibert, C, Peck, R, Mattocks, K, Braithwaite, S, Brandt, C, Cook, R, Conigliaro, J, Crothers, K, Chang, J, Crystal, S, Day, N, Erdos, J, Freiberg, M, Kozal, M, Gaziano, M, Gerschenson, M, Good, B, Gordon, A, Goulet, J, Kraemer, K, Lim, J, Maisto, S, Miller, P, O'Connor, P, Papas, R, Rinaldo, C, Roberts, M, Samet, J, Cohen, D, Consorte, A, Gordon, K, Kidwai, F, Levin, F, Mcginnis, K, Rambo, M, Rogers, J, Skanderson, M, and Whitsett, F.
Published: 2008

7. Importance of baseline prognostic factors with increasing time since initiation of highly active antiretroviral therapy: collaborative analysis of cohorts of HIV-1-infected patients

Author: Sterne, Jonathan A. C., May, Margaret, Sabin, Caroline, Phillips, Andrew, Costagliola, Dominique, Chêne, Geneviève, Justice, Amy C., De Wolf, Frank, Hogg, Robert, Battegay, Manuel, Monforte, Antonella D'Arminio, Gerdtkenheuer, Fa, Staszewski, Schlomo, Gill, John, Egger, Matthias, Casabona, Jordi, Dabis, Francxois, Kitahata, Mari, Leport, Catherine, Lundgren, Jens, Reiss, Peter, Saag, Michael, Weller, Ian, Beckthold, Brenda, Yip, Benita, Dauer, Brenda, Fusco, Jenifer, Lanoy, Emilie, Rickenbach, Martin, Lavignolle, Valerie, Van Sighem, Ard, Pereira, Edwige, Pezzotti, Patrizio, Schmeisser, Norbert, Billaud, E., Boué, F., Costagliola, D., Duval, X., Duvivier, C., Enel, P., Fournier, S., Gasnault, J., Gaud, C., Gilquin, J., Grabar, S., Khuong, M. A., Lang, J. M., Mary Krause, M., Matheron, S., Meyohas, M. C., Pialoux, G., Poizot Martin, I., Pradier, C., Rouveix, E., Salmon Ceron, D., Sobel, A., Tattevin, P., Tissot Dupont, H., Yasdanpanah, Y., Aronica, E, Tirard Fleury, V., Tortay, I., Abgrall, S., Guiguet, M., Lanoy, E., Leneman, H., Lièvre, L., Potard, V., Saidi, S., Vildé, J. L., Leport, C., Yeni, P., Bouvet, E., Gaudebout, C., Crickx, B., Picard Dahan, C., Weiss, L., Tisne Dessus, D., Sicard, D., Salmon, D., Auperin, I., Viard, J. P., Roudière, L., Fior, R., Delfraissy, J. F., Goujard, C., Lesprit, P. h., Jung, C., Meynard, J. L., Picard, O., Desplanque, N., Cadranel, J., Mayaud, C., Rozenbaum, W., Bricaire, F., Katlama, C., Herson, S., Simon, A., Decazes, J. M., Molina, J. M., Clauvel, J. P., Gerard, L., Sellier, P., Diemer, M., Dupont, C., Berthé, H., Saïag, P., Mortier, E., Chandemerle, C., De Truchis, P., Bentata, M., Honoré, P., Tassi, S., Jeantils, V., Mechali, D., Taverne, B., Laurichesse, H., Gourdon, F., Lucht, F., Fresard, A., Faller, J. P., Eglinger, P., Bazin, C., Verdon, R., Peyramond, D., Boibieux, A., Touraine, J. L., Livrozet, J. M., Trepo, C., Cotte, L., Ravaux, I., Delmont, J. P., Moreau, J., Gastaut, J. A., Soubeyrand, J., Retornaz, F., Blanc, P. A., Allegre, T., Galinier, A., Ruiz, J. M., Lepeu, G., Granet Brunello, P., Pelissier, L., Esterni, J. P., Nezri, M., Cohen Valensi, R., Laffeuillade, A., Chadapaud, S., Reynes, J., May, T., Rabaud, C., Raffi, F., Pugliese, P., Michelet, C., Arvieux, C., Caron, F., Borsa Lebas, F., Rey, D., Fraisse, P., Massip, P., Cuzin, L., Arlet Suau, E., Thiercelin Legrand, M. F., Sobesky, M., Pradinaud, R., Contant, M., Montroni, M., Scalise, G., Braschi, M. C., Riva, A., Tirelli, U., Cinelli, R., Pastore, G., Ladisa, N., Minafra, G., Suter, F., Arici, C., Pristera, R., Chiodo, F., Colangeli, V., Fiorini, C., Coronado, O., Carosi, G., Cadeo, G. P., Torti, C., Minardi, C., Bertelli, D., Rizzardini, G., Melzi, S., Manconi, P. E., Piano, P., Cosco, L., Scerbo, A., Vecchiet, J., D'Alessandro, M., Santoro, D., Pusterla, L., Carnevale, G., Citterio, P., Viganò, P., Mena, M., Ghinelli, F., Sighinolfi, L., Leoncini, F., Mazzotta, F., Pozzi, M., Lo Caputo, S., Vullo, Vincenzo, Lichtner, Miriam, Angarano, G., Grisorio, B., Saracino, A., Ferrara, S., Grima, P., Tundo, P., Pagano, G., Cassola, G., Alessandrini, A., Piscopo, R., Toti, M., Chigiotti, S., Soscia, F., Tacconi, L., Orani, A., Perini, P., Scasso, A., Vincenti, A., Chiodera, F., Castelli, P., Scalzini, A., Palvarini, L., Moroni, M., Lazzarin, A., Cargnel, A., Vigevani, G. M., Caggese, L., d'Arminio Monforte, A., Repetto, D., Galli, A., Merli, S., Pastecchia, C., Moioli, M. C., Esposito, R., Mussini, C., Abrescia, N., Chirianni, A., Izzo, C. M., Piazza, M., De Marco, M., Viglietti, R., Manzillo, E., Nappa, S., Antonucci, G., Iacomi, F., Narciso, P., Zaccarelli, M., Colomba, A., Abbadessa, V., Prestileo, T., Mancuso, S., Ferrari, C., Pizzaferri, P., Filice, G., Minoli, L., Bruno, R., Novati, S., Baldelli, F., Tinca, M., Petrelli, E., Cioppi, A., Alberici, F., Ruggieri, A., Menichetti, F., Martinelli, C., De Stefano, C., La Gala, A., Ballardini, G., Rizzo, E., Magnani, G., Ursitti, M. A., Arlotti, M., Ortolani, P., Cauda, R., Dianzani, F., Ippolito, G., Antinori, A., D'Elia, S., Petrosillo, N., De Luca, A., Bacarelli, A., Acinapura, R., De Longis, P., Brandi, A., Trotta, M. P., Noto, P., Capobianchi, M. R., Carletti, F., Girardi, E., Pezzotti, P., Rezza, G., Mura, M. S., Mannazzu, M., Caramello, P., Di Perri, G., Soranzo, M. L., Orofino, G. C., Arnaudo, I., Bonasso, M., Grossi, P. A., Basilico, C., Poggio, A., Bottari, G., Raise, E., Ebo, F., De Lalla, F., Tositti, G., Resta, F., Loso, K., Cozzi Lepri, A., Johnson, A. M., Mercey, D., Phillips, A., Johnson, M. A., Mocroft, A., Murphy, M., Weber, J., Scullard, G., Fisher, M., Battegay, M., Bernasconi, E., Böni, J., Bucher, H., Bürgisser, P. h., Cattacin, S., Cavassini, M., Dubs, R., Egger, M., Elzi, L., Erb, P., Fantelli, K., Fischer, M., Flepp, M., Fontana, A., Francioli, P., Hirschel, B., Soravia Dunand, V., Furrer, H., Gorgievski, M., Günthard, H., Kaiser, L., Kind, C., Klimkait, T. h., Lauper, U., Ledergerber, B., Opravil, M., Paccaud, F., Pantaleo, G., Perrin, L., Piffaretti, J. C., Rickenbach, M., Rudin, C., Schmid, P., Schüpbach, J., Speck, R., Telenti, A., Trkola, A., Vernazza, P., Buy, E., Bronsveld, W., Hillebrand Haverkort, M. E., Reiss, P., Back, N. K. T., Bakker, M. E. G., Berkhout, B., Jurriaans, S., Cuijpers, T. h., Rietra, P. J. G. M., Roozendaal, K. J., Pauw, W., Van Zanten, A. P., Smits, P. H. M., Von Blomberg, B. M. E., Savelkoul, P., Danner, S. A., Van Agtmael, M. A., Claessen, F. A. P., Perenboom, R. M., Rijkeboer, A., Van Vonderen, M., Kuijpers, T. W., Pajkrt, D., Scherpbier, H. J., Prins, J. M., Bos, J. C., Eeftinck Schattenkerk, J. K. M., Geerlings, S. E., Godfried, M. H., Lange, J. M. A., Van Leth, F. C., Lowe, S. H., Van Der Meer, J. T. M., Nellen, F. J. B., Pogány, K., Van Der Poll, T., Ruys, T. h. A., Sankatsing, S., Steingrover, R., Van Twillert, G., Van Der Valk, M., Van Vonderen, M. G. A., Vrouenraets, S. M. E., Van Vugt, M., Wit, F. W. M. N., Veenstra, J., Van Eeden, A., Veen, J. H., Van Dam, P. S., Roos, J. C., Brinkman, K., Frissen, P. H. J., Weigel, H. M., Mulder, J. W., Van Gorp, E. C. M., Meenhorst, P. L., Mairuhu, A. T. A., Richter, C., Van Der Berg, J., Van Leusen, R., Swanink, C. M. A., Vriesendorp, R., Jeurissen, F. J. F., Franck, P. F. H., Lampe, A. S., Kauffmann, R. H., Koger, E. L. W., Bravenboer, B., Ten Napel, C. H. H., Kootstra, G. J., Schirm, J., Bennw, C. A., Sprenger, H. G., Miesen, W. M. A. J., Doedens, R., Scholvinck, E. H., Ten Kate, R. W., Van Houte, D. P. F., Polee, M., Kroes, A. C. M., Claas, H. C. J., Kroon, F. P., Van Den, Broek, Van Dissel, J. T., Schippers, E. F., Bruggeman, C. A. M. V. A., Goossens, V. J., Schreij, G., Van De Geest, S., Verbon, A., Galama, J. M. D., Melchers, W. J. G., Poort, Y. A. G., Koopmans, P. P., Keuter, M., Post, F., Van Der Ven, A. J. A. M., Doornum, G. J. J., Niesters, M. G., Osterhaus, A. D. M. E., Schutten, M., Driessen, G., De Groot, R., Hartwig, N., Van Der Ende, M. E., Gyssens, I. C., Van Der Feltz, M., Den Hollander, J. G., De Marie, S., L. Nouwen, J., Rijnders, B. J. A., De Vries, T. E. M. S., Juttmann, J. R., Van De Heul, C., Van Kasteren, M. E. E., Boucher, C. A. B., Schuurman, R., Geelen, S. P. M., Wolfs, T. F. W., Schneider, M. M. E., Bonten, M. J. M., Borleffs, J. C. C., Ellerbroek, P. M., Hoepelman, I. M., Jaspers, C. A. J. J., Schouten, I., Schurink, C. A. M., Blok, W. L., Tanis, A. A., Groeneveld, P. H. P., Jansen, C. L., Hendriks, R., Veenendaal, D., Storm, H., Weel, J., Van Zeijl, J. H., Buiting, A. G. M., Swaans, C. A. M., Boel, E., Jansz, A. F., Losso, M., Duran, A., Vetter, N., Karpov, I., Vassilenko, A., Clumeck, N., Dewit, S., Poll, B., Colebunders, R., Machala, L., Rozsypal, H., Sedlacek, D., Gerstoft, J., Katzenstein, T., Hansen, A. B. E., Skinhøj, P., Nielsen, J., Lundgren, J., Benfield, T., Kirk, O., Pedersen, C., Zilmer, K., Girard, P. M., Saint Marc, T., Vanhems, P., Dabis, F., Dietrich, M., Manegold, C., Van Lunzen, J., Stellbrink, H. J., Staszewski, S., Bickel, M., Goebel, F. D., Fätkenheuer, G., Rockstroh, J., Schmidt, R., Kosmidis, J., Gargalianos, P., Sambatakou, H., Perdios, J., Panos, G., Filandras, A., Karabatsaki, E., Banhegyi, D., Mulcahy, F., Yust, I., Turner, D., Burke, M., Pollack, S., Hassoun, G., Sthoeger, Z., Maayan, S., Borghi, R., Cotugno, A. D., Gabbuti, A., Chiesi, A., Montesarchio, E., Finazzi, R., D'Arminio Monforte, A., Viksna, L., Chaplinskas, S., Hemmer, R., Staub, T., Bruun, J., Maeland, A., Ormaasen, V., Knysz, B., Gasiorowski, J., Horban, A., Prokopowicz, D., Wiercinska Drapalo, A., Boron Kaczmarska, A., Pynka, M., Beniowski, M., Mularska, E., Trocha, H., Antunes, F., Valadas, E., Mansinho, K., Matez, F., Duiculescu, D., Babes, Victor, Streinu Cercel, A., Vinogradova, E., Rakhmanova, A., Jevtovic, D., Mokráš, M., Staneková, D., González Lahoz, J., Sánchez Conde, M., García Benayas, T., Martin Carbonero, L., Soriano, V., Clotet, B., Jou, A., Conejero, J., Tural, C., Gatell, J. M., Miró, J. M., Blaxhult, A., Karlsson, A., Pehrson, P., Weber, R., Kravchenko, E., Chentsova, N., Barton, S., Brettle, R., Loveday, C., Antunes, Francisco, Blaxhult, Anders, Clumeck, Nathan, Gatell, Jose, Horban, Andrzej, Johnson, Anne, Katlama, Christine, Ledergerber, Bruno, Loveday, Clive, Vella, Stefano, Gjørup, I., Friis Moeller, N., Bannister, W., Mollerup, D., Podlevkareva, D., Holkmann Olsen, C., Kjær, J., Raffanti, Stephen, Dieterch, Douglas, Becker, Stephen, Scarsella, Anthony, Fusco, Gregory, Most, Bernard, Balu, Rukmini, Rana, Rashida, Beckerman, Robin, Ising, Theodore, Fusco, Jennifer, Irek, Renae, Johnson, Bernadette, Hirani, Ashwin, Edwinjesus, De, Pierone, Gerald, Lackey, Philip, Irek, Chip, Johnson, Alison, Burdick, John, Leon, Saul, Arch, Joseph, Helm, Eilke B., Carlebach, Amina, Axelller, Mu, Haberl, Annette, Nisius, Gabi, Lennemann, Tessa, Rottmann, Carsten, Wolf, Timo, Stephan, Christoph, Bickel, Markus, Manfredsch, Mo, Gute, Peter, Locher, Leo, Lutz, Thomas, Klauke, Stephan, Knecht, Gabi, Doerr, Hans W., Stu, Martinrmer, Von Hentig, Nils, Jennings, Beverly, Beylot, J., Chêne, G., Dupon, M., Longy Boursier, M., Pellegrin, J. L., Ragnaud, J. M., Salamon, R., Thiébaut, R., Lewden, C., Lawson Ayayi, S., Mercié, P., Moreau, J. F., Morlat, P., Bernard, N., Lacoste, D., Malvy, D., Neau, D., Blaizeau, M. J., Decoin, M., Delveaux, S., Hannapier, C., Labarrère, S., Lavignolle Aurillac, V., Uwamaliya Nziyumvira, B., Palmer, G., Touchard, D., Balestre, E., Alioum, A., Jacqmin Gadda, H., Bonarek, M., Bonnet, F., Coadou, B., Gellie, P., Nouts, C., Bocquentin, F., Dutronc, H., Lafarie, S., Aslan, A., Pistonne, T., Thibaut, P., Vatan, R., Chambon, D., De La Taille, C., Cazorla, C., Ocho, A., Viallard, J. F., Caubet, O., Cipriano, C., Lazaro, E., Couzigou, P., Castera, L., Fleury, H., Lafon, M. E., Masquelier, B., Pellegrin, I., Breilh, D., Blanco, P., Loste, P., Caunègre, L., Bonnal, F., Farbos, S., Ferrand, M., Ceccaldi, J., Tchamgoué, S., De Witte, S., Alexander, Chris, Barrios, Rolando, Braitstein, Paula, Brumme, Zabrina, Chan, Keith, Cote, Helen, Gataric, Nada, Geller, Josie, Guillemi, Silvia, Richard Harrigan, P., Harris, Marrianne, Joy, Ruth, Levy, Adrian, Montaner, Julio, Montessori, Val, Palepu, Anita, Phillips, Elizabeth, Phillips, Peter, Press, Natasha, Tyndall, Mark, Wood, Evan, Bhagani, S., Byrne, P., Carroll, A., Cuthbertson, Z., Dunleavy, A., Geretti, A. M., Heelan, B., Johnson, M., Kinloch de Loes, S., Lipman, M., Madge, S., Marshall, N., Nair, D., Nebbia, G., Prinz, B., Swaden, L., Tyrer, M., Youle, M., Chaloner, C., Grabowska, H., Holloway, J., Puradiredja, J., Ransom, D., Tsintas, R., Bansi, L., Fox, Z., Harris, E., Hill, T., Lampe, F., Lodwick, R., Reekie, J., Sabin, C., Smith, C., Amoah, E., Booth, C., Clewley, G., Garcia Diaz, A., Gregory, B., Labbett, W., Tahami, F., Thomas, M., Read, Ron, Fatkenheuer, G., Schmeisser, N., Voigt, K., Wasmuth, J. C., Wohrmann, A., Infectious diseases, AII - Amsterdam institute for Infection and Immunity, APH - Amsterdam Public Health, Medical Microbiology and Infection Prevention, Paediatric Infectious Diseases / Rheumatology / Immunology, Landsteiner Laboratory, ARD - Amsterdam Reproduction and Development, Graduate School, Cardiology, APH - Global Health, APH - Quality of Care, AII - Infectious diseases, AII - Inflammatory diseases, and Global Health
Subjects: Adult, medicine.medical_specialty, AIDS, CD4 counts, Highly active antiretroviral therapy, HIV, Prognosis, Substance abuse (intravenous), Adolescent, Anti-HIV Agents, Antiretroviral Therapy, Highly Active, CD4 Lymphocyte Count, Europe, HIV Infections, HIV-1, Humans, Middle Aged, North America, Risk Factors, Substance Abuse, Intravenous, Survival Analysis, Pharmacology (medical), Infectious Diseases, Cost effectiveness, Antiretroviral Therapy, Article, Acquired immunodeficiency syndrome (AIDS), Internal medicine, medicine, Highly Active, Survival analysis, Immunodeficiency, business.industry, Transmission (medicine), Hazard ratio, Substance Abuse, medicine.disease, Confidence interval, Physical therapy, Intravenous, business, Cohort study
Abstract: Background: The extent to which the prognosis for AIDS and death of patients initiating highly active antiretroviral therapy (HAART) continues to be affected by their characteristics at the time of initiation (baseline) is unclear. Methods: We analyzed data on 20,379 treatment-naive HIV-1- infected adults who started HAART in 1 of 12 cohort studies in Europe and North America (61,798 person-years of follow-up, 1844 AIDS events, and 1005 deaths). Results: Although baseline CD4 cell count became less prognostic with time, individuals with a baseline CD4 count 350 cells/μL (hazard ratio for AIDS = 2.3, 95% confidence interval [CI]: 1.0 to 2.3; mortality hazard ratio = 2.5, 95% CI: 1.2 to 5.5, 4 to 6 years after starting HAART). Rates of AIDS were persistently higher in individuals who had experienced an AIDS event before starting HAART. Individuals with presumed transmission by means of injection drug use experienced substantially higher rates of AIDS and death than other individuals throughout follow-up (AIDS hazard ratio = 1.6, 95% CI: 0.8 to 3.0; mortality hazard ratio = 3.5, 95% CI: 2.2 to 5.5, 4 to 6 years after starting HAART). Conclusions: Compared with other patient groups, injection drug users and patients with advanced immunodeficiency at baseline experience substantially increased rates of AIDS and death up to 6 years after starting HAART.
Published: 2007

8. Epidemiology and clinical features of vivax malaria imported to Europe: Sentinel surveillance data from TropNetEurop

Author: Mühlberger, N, Jelinek, T, Gascon, J, Probst, M, Zoller, T, Schunk, M, Beran, J, Gjørup, I, Behrens, Rh, Clerinx, J, Björkman, A, Mcwhinney, P, Matteelli, A, Lopez-Velez, R, Bisoffi, Z, Hellgren, U, Puente, S, Schmid, Ml, Myrvang, B, Holthoff-Stich, Ml, Laferl, H, Hatz, C, Kollaritsch, H, Kapaun, A, Knobloch, J, Iversen, J, Kotlowski, A, Malvy, Dj, Kern, P, Fry, G, Siikamaki, H, Schulze, Mh, Soula, G, Paul, M, i Prat J, Gómez, Lehmann, V, Bouchaud, O, da Cunha, S, Atouguia, J, and Boecken, G
Subjects: Adult, Male, Travel, lcsh:Arctic medicine. Tropical medicine, lcsh:RC955-962, Research, imported, Animals, Europe, Female, Humans, Malaria, Vivax, Plasmodium vivax, Sentinel Surveillance, Vivax, Malaria, lcsh:Infectious and parasitic diseases, parasitic diseases, lcsh:RC109-216
Abstract: Background Plasmodium vivax is the second most common species among malaria patients diagnosed in Europe, but epidemiological and clinical data on imported P. vivax malaria are limited. The TropNetEurop surveillance network has monitored the importation of vivax malaria into Europe since 1999. Objectives To present epidemiological and clinical data on imported P. vivax malaria collected at European level. Material and methods Data of primary cases of P. vivax malaria reported between January 1999 and September 2003 were analysed, focusing on disease frequency, patient characteristics, place of infection, course of disease, treatment and differences between network-member countries. Results Within the surveillance period 4,801 cases of imported malaria were reported. 618 (12.9%) were attributed to P. vivax. European travellers and immigrants were the largest patient groups, but their proportion varied among the reporting countries. The main regions of infection in descending order were the Indian subcontinent, Indonesia, South America and Western and Eastern Africa, as a group accounting for more than 60% of the cases. Regular use of malaria chemoprophylaxis was reported by 118 patients. With 86 (inter-quartile range 41–158) versus 31 days (inter-quartile range 4–133) the median symptom onset was significantly delayed in patients with chemoprophylaxis (p < 0.0001). Common complaints were fever, headache, fatigue, and musculo-skeletal symptoms. All patients survived and severe clinical complications were rare. Hospitalization was provided for 60% and primaquine treatment administered to 83.8% of the patients, but frequencies varied strongly among reporting countries. Conclusions TropNetEurop data can contribute to the harmonization of European treatment policies.
Published: 2004

9. Imported Schistosomiasis in Europe: Sentinel Surveillance Data from TropNetEurop

Author: Grobusch, M. P., primary, Mühlberger, N., additional, Jelinek, T., additional, Bisoffi, Z., additional, Corachán, M., additional, Harms, G., additional, Matteelli, A., additional, Fry, G., additional, Hatz, C., additional, Gjørup, I., additional, Schmid, M. L., additional, Knobloch, J., additional, Puente, S., additional, Bronner, U., additional, Kapaun, A., additional, Clerinx, J., additional, Nielsen, L. N., additional, Fleischer, K., additional, Beran, J., additional, Cunha, S., additional, Schulze, M., additional, Myrvang, B., additional, and Hellgren, U., additional
Published: 2006
Full Text: View/download PDF

10. Changing epidemiology of HBV infection in Danish children

Author: Gjørup, I, primary
Published: 2003
Full Text: View/download PDF

11. Development of stress ulcers assessed by gastric electrical potential difference, pH of gastric juice, and endoscopy in patients in the intensive care unit

Author: Rubinstein, E, Gjørup, I, Schulze, S, Jonsson, T, Højgaard, L, Rubinstein, E, Gjørup, I, Schulze, S, Jonsson, T, and Højgaard, L
Abstract: OBJECTIVE: To assess measurement of gastric electrical potential difference, pH of gastric mucosa, and endoscopic findings in patients in intensive care units who are at risk of developing stress ulcers.DESIGN: Open comparison with age- and sex-matched control subjects.SETTING: Herlev Hospital, Denmark.SUBJECTS: Sixteen consecutive patients with no history of gastrointestinal haemorrhage, coagulopathy, or ulcer disease who had been admitted to the intensive care unit, and 16 age- and sex-matched outpatients with normal endoscopic findings.INTERVENTIONS: Upper gastrointestinal endoscopy, during which any lesions that were found were scored according to severity, the gastric potential difference, and the pH of gastric juice were measured.OUTCOME MEASURES: Correlation between the incidence of stress ulceration found at endoscopy, gastric potential difference, and gastric pH.RESULTS: Gastric potential difference was significantly reduced and gastric pH significantly increased in the patients in the intensive care unit (p less than 0.05 in both cases), all of whom had stress ulcers in more than one gastric segment. Nine of the patients had gastric pH readings of greater than 4.CONCLUSION: Gastric electrical potential difference may be useful measurement for the assessment of stress ulceration in patients in intensive care units.
Published: 1992

12. Pancreatic Secretion of Zinc and Copper in Normal Subjects and in Patients with Chronic Pancreatitis

Author: Gjørup, I., primary, Petronijevic, L., additional, Rubinstein, E., additional, Andersen, B., additional, Worning, H., additional, and Burcharth, F., additional
Published: 1991
Full Text: View/download PDF

13. The Effect of the Benzodiazepine Antagonist Flumazenil on the Sequels of Diazepam Given before Upper Gastrointestinal Endoscopy a Double-Blind Randomized Trial

Author: Gjørup, I., primary, Forrest, M., additional, Vilien, M., additional, and Andersen, B., additional
Published: 1991
Full Text: View/download PDF

14. Imported Schistosomiasis in Europe: Sentinel Surveillance Data from TropNetEurop.

Author: Grobusch, M. P., Mühlberger, N., Jelinek, T., Bisoffi, Z., Corachán, M., Harms, G., Matteelli, A., Fry, G., Hatz, C., Gjørup, I., Schmid, M. L., Knobloch, J., Puente, S., Bronner, U., Kapaun, A., Clerinx, J., Nielsen, L. N., Fleischer, K., Beran, J., and da Cunha, S.
Subjects: SCHISTOSOMIASIS, DISEASE prevalence, COMMUNICABLE diseases, TRAVEL hygiene, PUBLIC health
Abstract: The article presents data from the first 3 years of sentinel surveillance for imported schistosomiasis in Europe from the European Network on Imported Infectious Diseases Surveillance (TropNetEurop). An analysis of reports for epidemiologic and clinical features to generate valid data on imported infectious diseases is tackled. It reveals the difference of the pattern of regions where immigrants contracted schistosomiasis from the spatial distribution of schistosomiasis foci in endemic areas.
Published: 2003
Full Text: View/download PDF

15. Age as a Risk Factor for Severe Manifestations and Fatal Outcome of Falciparum Malaria in European Patients: Observations from TropNetEurop and SIMPID Surveillance Data.

Author: Mühlberger, N., Jelinek, T., Behrens, R.H., Gjørup, I., Coulaud, J.P., Clerinx, J., Puente, S., Burchard, G., Gascon, J., Grobusch, M.P., Weitzel, T., Zoller, T., Kollaritsch, H., Beran, J., Iversen, J., Hatz, C., Schmid, M.L., Björkman, A., and Fleischer, K.
Subjects: RISK of malaria, AGE factors in disease
Abstract: Reevaluates previous findings indicating that age is a risk factor for severe falciparum malaria in nonimmune patients. Association of antimalarial chemoprophylaxis with a lower-case-fatality rate and a lower frequency of cerebral complications; Evidence that falciparum malaria is more serious in older patients.
Published: 2003

16. Epidemiology and Clinical Features of Imported Dengue Fever in Europe: Sentinel Surveillance Data from TropNetEurop.

Author: Jelinek, T., Mühlberger, N., Harms, G., Corachán, M., Grobusch, M.P., Knobloch, J., Bronner, U., Laferl, H., Kapaun, A., Bisoffi, Z., Clerinx, J., Puente, S., Fry, G., Schulze, M., Hellgren, U., Gjørup, I., Chalupa, P., Hatz, C., and Matteelli, A.
Subjects: DENGUE, DENGUE viruses, TRAVEL hygiene, PUBLIC health, HEMORRHAGIC fever
Abstract: Travelers have the potential both to acquire and to spread dengue virus infection. The incidence of dengue fever (DF) among European travelers certainly is underestimated, because few centers use standardized diagnostic procedures for febrile patients. In addition, DF is currently not reported in most European public health systems. Surveillance has commenced within the framework of a European Network on Imported Infectious Disease Surveillance (TropNetEurop) to gain information on the quantity and severity of cases of dengue imported into Europe. Descriptions of 294 patients with DF were analyzed for epidemiological information and clinical features. By far the most infections were imported from Asia, which suggests a high risk of DF for travelers to that region. Dengue hemorrhagic fever occurred in 7 patients (2.4%) all of whom recovered. Data reported by member sites of the TropNetEurop can contribute to understanding the epidemiology and clinical characteristics of imported DF. [ABSTRACT FROM AUTHOR]
Published: 2002

17. Are Specific Antiretrovirals associated with an Increased Risk of Discontinuation due to Toxicities or Patient/Physician Choice in patients with Hepatitis C Virus Coinfection?

Author: Mocroft, Amanda, Rockstroh, Jurgen, Soriano, Vincent, Ledergerber, Bruno, Kirk, Ole, Vinogradova, Elena, Reiss, Peter, Katlama, Christine, Phillips, Andrew N, Lundgren, Jens D, Losso, M, Duran, A, Vetter, N, Karpov, I, Vassilenko, A, Clumeck, N, De Wit, S, Poll, B, Machala, L, Rozsypal, H, Sedlacek, D, Nielsen, J, Lundgren, J, Benfield, T, Kirk, O, Gerstoft, J, Katzenstein, T, Hansen, A-B E, Skinhøj, P, Pedersen, C, Zilmer, K, Katlama, C, Viard, J-P, Girard, P-M, Marc, T Saint, Vanhems, P, Pradier, C, Dabis, F, Dietrich, M, Manegold, C, Van Lunzen, J, Stellbrink, H-J, Staszewski, S, Bickel, M, Goebel, F-D, Fätkenheuer, G., Rockstroh, J, Schmidt, R, Kosmidis, J, Gargalianos, P, Sambatakou, H, Perdios, J, Panos, G, Banhegyi, D, Mulcahy, F, Yust, I, Turner, D, Burke, M, Pollack, S, Hassoun, G, Sthoeger, Z, Maayan, S, Vella, S, Chiesi, A, Arici, C, Pristerá, R, Mazzotta, F, Gabbuti, A, Esposito, R, Bedini, A, Chirianni, A, Montesarchio, E, Vullo, V, Santopadre, P, Narciso, P, Antinori, A, Franci, P, Zaccarelli, M, Lazzarin, A, Finazzi, R, Monforte, A D'Arminio, Viksna, L, Chaplinskas, S, Hemmer, R, Staub, T, Reiss, P, Bruun, J, Maeland, A, Ormaasen, V, Knysz, B, Gasiorowski, J, Horban, A, Prokopowicz, D, Wiercinska-Drapalo, A, Boron-Kaczmarska, A, Pynka, M, Beniowski, M, Mularska, E, Trocha, H, Antunes, F, Valadas, E, Mansinho, K, Matez, F, Duiculescu, D, Streinu-Cercel, A, Vinogradova, E, Rakhmanova, A, Jevtovic, D, Mokrás, M, Staneková, D, González-Lahoz, J, Sánchez-Conde, M, García-Benayas, T, Martin-Carbonero, L, Soriano, V, Clotet, B, Jou, A, Conejero, J, Tural, C, Gatell, JM, Miró, JM, Blaxhult, A, Karlsson, A, Pehrson, P, Ledergerber, B, Weber, R, Francioli, P, Telenti, A, Hirschel, B, Soravia-Dunand, V, Furrer, H, Chentsova, N, Barton, S, Johnson, AM, Mercey, D, Phillips, A, Johnson, MA, Mocroft, A, Murphy, M, Weber, J, Scullard, G, Fisher, M, Brettle, R, Loveday, C, Clotet, B, Antunes, Francisco, Blaxhult, Anders, Clumeck, Nathan, Gatell, Jose, Horban, Andrzej, Johnson, Anne, Katlama, Christine, Ledergerber, Bruno, Loveday, Clive, Phillips, Andrew, Reiss, Peter, Vella, Stefano, Lundgren, J, Gjørup, I, Kirk, O, Friis-Moeller, N, Mocroft, A, Cozzi-Lepri, A, Bannister, W, Mollerup, D, Podlevkareva, D, Olsen, C Holkmann, and Kjær, J
Abstract: Background Liver damage associated with hepatitis C (HCV) may influence the likelihood of experiencing discontinuation due to toxicities or patient/physician choice (TOXPC) in patients taking combination antiretroviral therapy (cART). Little information to address this concern is available from clinical trials as patients with HCV are often excluded.Aims To compare incidence rates of discontinuation due to TOXPC associated with specific antiretrovial drugs in patients with or without HCV.Patients/methods A total of 4929 patients from EuroSIDA under follow-up from January 1999 on a specific nucleoside pair (zidovudine/lamivudine, didanosine/stavudine, stavudine/lamivudine, or other) with a third drug (abacavir, nelfinavir, indinavir, nevirapine, efavirenz, lopinavir/ ritonavir or other boosted-protease inhibitor (PI)-containing regimen) and with known HCV serostatus were studied for the incidence of discontinuation of any nucleoside pair or third drug due to TOXPC. Incidence rate ratios were derived from Poisson regression models.Results In total 1358 patients had HCV (27.5%). During 12 799 person-years of follow-up there were 2141 discontinuations due to TOXPC for nucleoside pairs and 2501 for third drugs. The incidence of discontinuation due to TOXPC was consistently higher in patients with HCV after stratification by nucleoside pair or third drug. After adjustment for CD4+count, gender, exposure group, time on HAART, region and treatment regimen, there were few differences in the rate of discontinuation due to TOXPC in those with HCV compared with those without for any nucleoside pairs or third drugs. Similar results were seen when concentrating on discontinuation due to toxicities alone.Conclusions Although patients with HCV generally had higher rates of discontinuation due to TOXPC compared with patients without HCV, there was little evidence to suggest that this was associated with any specific nucleoside pair or third drug used as part of cART. Our results do not suggest that any specific component of cART is more poorly tolerated in patients with HCV or that the presence of HCV should influence the choice between antiretrovirals used as part of a cART regimen.
Published: 2005
Full Text: View/download PDF

18. Thymidine Analogue Mutation Profiles: Factors Associated with Acquiring Specific Profiles and their Impact on the Virological Response to Therapy

Author: Cozzi-Lepri, Alessandro, Ruiz, Lidia, Loveday, Clive, Phillips, Andrew N, Clotet, Bonaventura, Reiss, Peter, Ledergerber, Bruno, Holkmann, Christian, Staszewski, Schlomo, Lundgren, Jens D, Losso, M, Duran, A., Vetter, N, Clumeck, N, De Wit, S, Poll, B, Colebunders, R, Machala, L, Rozsypal, H, Nielsen, J, Lundgren, J, Kirk, O, Olsen, CH, Gerstoft, J, Katzenstein, T, Hansen, ABE, Skinhøj, P, Pedersen, C, Zilmer, K, Rauka, M, Katlama, C, De Sa, M, Viard, J-P, Marc, T Saint, Vanhems, P, Pradier, C, Dietrich, M, Manegold, C, Van Lunzen, J, Stellbrink, H-J, Miller, V, Staszewski, S, Goebel, FD, Salzberger, B, Rockstroh, J, Schmidt, RE, Stoll, M, Kosmidis, J, Gargalianos, P, Sambatakou, H, Perdios, J, Panos, G, Banhegyi, D, Mulcahy, F, Yust, I, Burke, M, Pollack, S, Hassoun, J, Sthoeger, Z, Maayan, S, Vella, S, Chiesi, A, Arici, C, Pristerá, R, Mazzotta, F, Gabbuti, A, Esposito, R, Bedini, A, Chirianni, A, Montesarchio, E, Vullo, V, Santopadre, P, Narciso, P, Antinori, A, Franci, P, Zaccarelli, M, Lazzarin, A, Castagna, A, Monforte, D'Arminio, Viksna, L, Rozentale, B, Chaplinskas, S, Hemmer, R, Staub, T, Reiss, P, Bruun, J, Maeland, A, Ormaasen, V, Knysz, B, Gasiorowski, J, Horban, A, Prokopowicz, D, Drapalo, A Wiercinska, Kaczmarska, A Boron, Pynka, M, Beniowski, M, Trocha, H, Smiatacz, T, Antunes, F, Mansinho, K, Maltez, F, Duiculescu, D, Babes, V, Cercel, A Streinu, Mokrás, M, Staneková, D, González-Lahoz, J, Diaz, B, García-Benayas, T, Carbonero, L Martin, Soriano, V, Clotet, B, Jou, A, Conejero, J, Tural, C, Gatell, JM, Miró, JM, Zamora, L, Blaxhult, A, Karlsson, A, Pehrson, P, Ledergerber, B, Weber, R, Francioli, P, Hirschel, B, Schiffer, V, Furrer, H, Chentsova, N, Barton, S, Johnson, AM, Mercey, D, Youle, M, Phillips, A, Johnson, MA, Mocroft, A, Murphy, M, Weber, J, Scullard, G, Fisher, M, Brettle, R, Loveday, C, Clotet, B, Ruiz, L, Antunes, F, Blaxhult, A, Clumeck, N, Gatell, J, Horban, A, Johnson, A, Katlama, C, Ledergerber, B, Loveday, C, Phillips, A, Reiss, P, Vella, S, Lundgren, J, Gjørup, I, Kirk, O, Moeller, N Friis, Mocroft, A, Lepri, A Cozzi, Bannister, W, Mollerup, D, Nielsen, M, Hansen, A, Kristensen, D, Kolte, L, Hansen, L, and Kjær, J
Abstract: Background Studies have suggested that HIV-1 may develop thymidine analogue mutations (TAMs) by one of two distinct pathways – the TAM1 pathway (including mutations 41L, 210W and 215Y) or the TAM2 pathway (including mutations 67N, 70R and 219E/Q) – under the pressure of a not fully suppressive thymidine-analogue-containing regimen.Methods Frozen plasma samples stored in the EuroSIDA repository were selected and sent to two central laboratories for genotypic analysis. We considered 733 patients with at least one genotypic test showing =1 TAMs (the first of these tests in chronological order was used). TAM1 and TAM2 genotypic profiles were defined in accordance with previous literature. Statistical modelling involved logistic regression and linear regression analysis for censored data.Results The observed frequencies of patterns classifiable as TAM1 or TAM2 profiles were markedly higher than the probabilities of falling into these classifications by chance alone. The chance of detecting a TAM2 profile increased by 25% per additional year of exposure to zidovudine. We found that mutations 67N and 184V were not associated with a particular TAM profile. In the presence of TAM2 profiles, the adjusted mean difference in the 6-month viral reduction was 0.96 log10copies/ml (95% confidence interval: 0.20; 1.73) higher in patients who started stavudine-containing regimens instead of zidovudine-containing regimens.Conclusions This study provides evidence that the suggested TAM clustering is a real phenomenon and that it may be driven by which thymidine analogue the patients has used. In patients with TAM2-resistant viruses, stavudine appears to retain greater viral activity than zidovudine.
Published: 2005
Full Text: View/download PDF

19. Response to Antiretroviral Therapy among Patients Exposed to Three Classes of Antiretrovirals: Results from the Eurosida Study

Author: Mocroft, A, Phillips, AN, Friis-Møller, N, Colebunders, R, Johnson, AM, Hirschel, B, Saint-Marc, T, Staub, T, Clotet, B, Lundgren, JD, Ledergerber, B, Antunes, F, Blaxhult, A, Clumeck, N, Gatell, JM, Horban, A, Johnson, AM, Katlama, C, Loveday, C, Phillips, A, Reiss, P, Vella, S, Vetter, N, Clumeck, N, Hermans, P, Sommereijns, B, Colebunders, R, Machala, L, Rozsypal, H, Nielsen, J, Lundgren, J, Benfield, T, Kirk, O, Gerstoft, J, Katzenstein, T, Røge, B, Skinhøj, P, Pedersen, C, Katlama, C, Rivière, C, Viard, J-P, Saint-Marc, T, Vanhems, P, Pradier, C, Dietrich, M, Manegold, C, van Lunzen, J, Miller, V, Staszewski, S, Goebel, F-D, Salzberger, Bernd, Rockstroh, J, Kosmidis, J, Gargalianos, P, Sambatakou, H, Perdios, J, Panos, G, Karydis, I, Filandras, A, Banhegyi, D, Mulcahy, F, Yust, I, Turner, D, Pollack, S, Ben-Ishai, Z, Bentwich, Z, Maayan, S, Vella, S, Chiesi, A, Arici, C, Pristerá, R, Mazzotta, F, Gabbuti, A, Esposito, R, Bedini, A, Chirianni, A, Montesarchio, E, Vullo, V, Santopadre, P, Narciso, P, Antinori, A, Franci, P, Zaccarelli, M, Lazzarin, A, Finazzi, R, Monforte, A D'Arminio, Hemmer, R, Staub, T, Reiss, P, Bruun, J, Maeland, A, Ormaasen, V, Knysz, B, Gasiorowski, J, Horban, A, Prokopowicz, D, Wiercinska-Drapalo, A, Boron-Kaczmarska, A, Pynka, M, Beniowski, M, Trocha, H, Antunes, F, Mansinho, K, Proenca, R, González-Lahoz, J, Diaz, B, García-Benayas, T, Martin-Carbonero, L, Soriano, V, Clotet, B, Jou, A, Conejero, J, Tural, C, Gatell, JM, Miró, JM, Blaxhult, A, Heidemann, B, Pehrson, P, Ledergerber, B, Weber, R, Francioli, P, Telenti, A, Hirschel, B, Soravia-Dunand, V, Barton, S, Johnson, AM, Mercey, D, Phillips, A, Loveday, C, Johnson, MA, Mocroft, A, Pinching, A, Parkin, J, Weber, J, Scullard, G, Fisher, M, Brettle, R, Lundgren, J, Gjørup, I, Kirk, O, Friis-Moeller, N, Mocroft, A, Cozzi-Lepri, A, Mollerup, D, Nielsen, M, Hansen, A, Kristensen, D, Aabolt, S, Cimposeu, P, Hansen, L, and Kjær, J
Abstract: There is an increasing proportion of HIV-positive patients exposed to all licensed classes of antiretrovirals, and the response to salvage regimens may be poor. Among over 8500 patients in EuroSIDA, the proportion of treated patients exposed to nucleosides, protease inhibitors (PIs) and non-nucleoside reverse transcriptase inhibitor (NNRTI) increased from 0% in 1996 to 47% in 2001. Four-hundred-and-thirteen patients, who had failed virologically two highly active antiretroviral therapy (HAART) regimens and experienced all three main drug classes, started a salvage regimen of at least three drugs, in which at least one new PI or NNRTI was included. Median viral load was 4.7 log copies/ml [Interquartile range (IQR) 4.2–5.2], CD4 lymphocyte count 150/mm3(IQR 60–274/mm3) and follow-up 14 months. Of these patients, 283 (69%) subsequently experienced at least a 1 log decline in viral load and 202 (49%) achieved a viral load <500 copies/ml. Conversely, the CD4 count halved from the baseline value in 88 (21%), and 45 (11%) experienced a new AIDS-defining disease. In multivariable analyses, a 1 log viral load reduction was related to baseline viral load [relative hazard (RH) 1.27 per 1 log higher; P=0.008], a previous viral load of less than 500 copies/ml (RH 1.69; P=0.002), more recent initiation of the regimen (RH 1.36 per year more recent; P=0.02), number of new drugs in the regimen (RH 1.20 per drug; P=0.02), time since start of antiretroviral therapy (RH 0.94 per extra year; P=0.035) and time spent on HAART with viral load >1000 copies/ml (RH 0.96 per extra month; P=0.0001). Analysis of factors associated with CD4 count decline and new AIDS disease also indicated improved outcomes in more recent times and a tendency for a better response in those starting more new drugs, but no relationship with the total number of drugs. Outcomes in people starting salvage regimens appear to depend on the number of new drugs started but not on the total number of drugs being used.
Published: 2002
Full Text: View/download PDF

20. Serum Selenium and Zinc Concentrations in Morbid Obesity: Comparison of Controls and Patients with Jejunoileal Bypass.

Author: Gjørup, I., Gjørup, T., and Andersen, B.
Published: 1988
Full Text: View/download PDF

21. Ethanol in pancreatic juice after oral and intravenous administration.

Author: Gjørup, I, Dueholm, S, Andersen, B, and Burcharth, F
Abstract: Six patients with a drain in the main pancreatic duct were studied. Ethanol was given orally with individually adjusted doses aiming at a blood value of 0.8/1000 (17.6 mmol/l). Concentrations of ethanol in venous blood and pancreatic juice were recorded for three hours. Similar studies were made when ethanol was administered as an intravenous priming dose followed by a maintenance infusion. After orally administered ethanol, pancreatic juice values were higher than those in blood for a short period of time. The relations between median concentrations and time were incongruous curves consistent with a significant treatment by time interaction. Intravenous administration resulted in a similar pattern, but the interaction was not statistically significant. These findings indicate that the human pancreas may secrete ethanol. [ABSTRACT FROM PUBLISHER]
Published: 1990

22. Epidemiology of cryptosporidiosis among European AIDS patients

Author: Pedersen, C., Danner, S., Lazzarin, A., Glauser, M. P., Weber, R., Katlama, C., Barton, S., Lundgren, J. D., Clumeck, N., Dewit, S., Sommereijns, B., Nielsen, J. O., Nielsen, T., Jensen, G., Skinhøj, P., Bentsen, K., Gerstoft, J., Melbye, M., Ranki, A., Valle, S. L., Berlureau, P., Dietrich, M., Schwander, S., Goebel, F. D., Kosmidis, J., Stergiou, G., Gouzia, T., Papadopoulos, A., Banhegyi, D., Mulcahy, F., Yust, I., Ben-Ishai, Z., Bentwich, Z., Sacks, T., Maayan, S., Velia, S., Chiesi, A., Ancarani, F., Scalise, G., Bertaggia, A., Francavilla, E., Calonghi, G., Cargnel, A., Arlotti, M., Ciammarughi, R., Colomba, A., Delalla, F., Fassio, P., Ferlini, A., Fiaccadori, F., Pasetti, G., Giannelli, F., Grillone, W., D'arminio Monforte, A., Mignani, E., Nunnari, A., Ortona, L., Panichi, G., Pauluzzi, S., Piersantelli, N., Ranieri, S., Ricciardiello, P., Roscioli, B., Soranzo, M., Hemmer, R., Reiss, Peter, Antunes, F., Proenca, R., Gonzilez-Lahoz, J., Polo, Rosa, Clotet, B., Gatell, J., Buira, E., Miro, J., Pehrson, P., Liithy, R., Ledergerber, B., Olsson, C., Glauser, M., Hirschel, B., Johnson, A., Hawkes, S., Phillips, A., Morcinek, J., Pinching, A., Coleman, D., Gjørup, I., Nielsen, J., Nieport, C., Teglbjaerg, L., Thomval, A., and Internal medicine
Subjects: Adult, Male, Pediatrics, medicine.medical_specialty, Cryptosporidiosis, Dermatology, Acquired immunodeficiency syndrome (AIDS), Risk Factors, Epidemiology, medicine, Humans, Homosexuality, Male, Risk factor, Substance Abuse, Intravenous, Sida, Retrospective Studies, Acquired Immunodeficiency Syndrome, AIDS-Related Opportunistic Infections, biology, Transmission (medicine), business.industry, biology.organism_classification, medicine.disease, CD4 Lymphocyte Count, Europe, Log-rank test, Diarrhea, Infectious Diseases, Multivariate Analysis, Immunology, Female, Viral disease, medicine.symptom, business, Research Article
Abstract: Objective: To study epidemiology and possible risk factors associated with the development of cryptosporidiosis among European patients with AIDS. Methods: An inception cohort of 6548 patients with AIDS, consecutively diagnosed from 1979 to 1989, from 52 centres in 17 European countries was studied. Data on all AIDS defining events were collected retrospectively from patients' clinical records. Kaplan-Meier estimates, log rank tests and Cox proportional hazard models were used to examine for possible risk factors associated with cryptosporidiosis. Results: Cryptosporidiosis was diagnosed in 432 (6.6%) patients, 216 at time of the AIDS diagnosis and 216 during follow-up. The probability of being diagnosed with cryptosporidiosis at AIDS diagnosis was significantly lower for intravenous drug users (1.3%) than for homosexual men (4.1%) and for patients belonging to other transmission categories (4.0%) (p < 0.001). The probability was also higher for patients from Central Europe compared with patients from South Europe (4.1% versus 2.5%, p = 0.005). The rate of developing cryptosporidiosis after the diagnosis of AIDS was 3 per 100 patient years of follow-up. The rate was significantly lower for intravenous' drug users than for homosexual men (relative risk 0.34, 95% confidence limits 0.22-0.54) and for women compared with men (RR 0.43 (0.21-0.87)). The risk was higher in North Europe than in South and Central Europe. In a multivariate analysis only transmission category remained a significant predictor for the development of cryptosporidiosis. Conclusion: The development of cryptosporidiosis in AIDS patients may be associated with sexual risk behaviour.
Full Text: View/download PDF

23. Molecular surveillance of the antifolate-resistant mutation I164L in imported African isolates of Plasmodium falciparum in Europe: sentinel data from TropNetEurop

Author: Wichmann, O., Jelinek, T., Peyerl-Hoffmann, G., Mühlberger, N., Grobusch, M. P., Joaquim Gascon, Matteelli, A., Hatz, C., Laferl, H., Schulze, M., Burchard, G., Da Cunha, S., Beran, J., Mcwhinney, P., Kollaritsch, H., Kern, P., Cuadros, J., Alifrangis, M., Gjørup, I., and Infectious diseases
Subjects: Falciparum, lcsh:Arctic medicine. Tropical medicine, lcsh:RC955-962, Research, Plasmodium falciparum, Drug Resistance, Drug Resistance, Multiple, lcsh:Infectious and parasitic diseases, Amino Acid Substitution, Animals, Folic Acid Antagonists, Humans, Isoleucine, Leucine, Malaria, Falciparum, Population Surveillance, Malaria, parasitic diseases, lcsh:RC109-216, Multiple
Abstract: Background Malaria parasites that carry the DHFR-mutation I164L are not only highly resistant to sulfadoxine-pyrimethamine but also to the new antimalarial drug chlorproguanil-dapsone. The spread of this mutation in Africa would result in a public health disaster since there is a lack of effective alternatives that are both affordable and safe. Up to now, this mutation has only been described in Asian and Latin-American countries. The objective of this study was to assess the prevalence of this mutation in African isolates of Plasmodium falciparum that have been imported into Europe through travellers. Methods TropNetEurop is a network for the surveillance of travel-associated diseases and seems to cover approximately 12% of all malaria cases imported into Europe. Within this network we screened 277 imported African isolates of P. falciparum with the help of PCR- and enzyme-digestion-methods for the antifolate-resistant mutation I164L. Results The I164L mutation was not detected in any of the isolates tested. Discussion Continuous molecular surveillance of mutations in P. falciparum, as it is practised within TropNetEurop, is an essential tool for the understanding and early detection of the spread of antimalarial drug resistance in Africa.

24. Age as a Risk Factor for Severe Manifestations and Fatal Outcome of Falciparum Malaria in European Patients: Observations from TropNetEurop and SIMPID Surveillance Data

Author: Mühlberger, N., Jelinek, T., Behrens, R. H., Gjørup, I., Coulaud, J. P., Clerinx, J., Puente, S., Burchard, G., Gascon, J., Grobusch, M. P., Weitzel, T., Zoller, T., Kollaritsch, H., Beran, J., Iversen, J., Hatz, C., Schmid, M. L., Björkman, A., Fleischer, K., Bisoffi, Z., Guggemos, W., Knobloch, J., Matteelli, A., Schulze, M. H., Laferl, H., Kapaun, A., McWhinney, P., Lopez-Velez, R., Fôtkenheuer, G., Kern, P., Zieger, B. W., Kotlowski, A., Fry, G., Cuadros, J., Myrvang, B., Mühlberger, N., Jelinek, T., Behrens, R. H., Gjørup, I., Coulaud, J. P., Clerinx, J., Puente, S., Burchard, G., Gascon, J., Grobusch, M. P., Weitzel, T., Zoller, T., Kollaritsch, H., Beran, J., Iversen, J., Hatz, C., Schmid, M. L., Björkman, A., Fleischer, K., Bisoffi, Z., Guggemos, W., Knobloch, J., Matteelli, A., Schulze, M. H., Laferl, H., Kapaun, A., McWhinney, P., Lopez-Velez, R., Fôtkenheuer, G., Kern, P., Zieger, B. W., Kotlowski, A., Fry, G., Cuadros, J., and Myrvang, B.
Abstract: Previous studies have indicated that age is a risk factor for severe falciparum malaria in nonimmune patients. The objectives of this study were to reevaluate previous findings with a larger sample and to find out how strongly clinical outcomes for elderly patients differ from those for younger patients. Results of adjusted analyses indicated that the risks of death due to falciparum malaria, of experiencing cerebral or severe disease in general, and of hospitalization increased significantly with each decade of life. The case-fatality rate was almost 6 times greater among elderly patients than among younger patients, and cerebral complications occurred 3 times more often among elderly patients. Antimalarial chemoprophylaxis was significantly associated with a lower case-fatality rate and a lower frequency of cerebral complications. Women were more susceptible to cerebral complications than were men. Our study provides evidence that falciparum malaria is more serious in older patients and demonstrates that clinical surveillance networks are capable of providing quality data for investigation of rare events or diseases

25. Epidemiology and Clinical Features of Imported Dengue Fever in Europe: Sentinel Surveillance Data from TropNetEurop

Author: Jelinek, T., Mühlberger, N., Harms, G., Corachán, M., Grobusch, M. P., Knobloch, J., Bronner, U., Laferl, H., Kapaun, A., Bisoffi, Z., Clerinx, J., Puente, S., Fry, G., Schulze, M., Hellgren, U., Gjørup, I., Chalupa, P., Hatz, C., Matteelli, A., Schmid, M., Nielsen, L. N., da Cunha, S., Atouguia, J., Myrvang, B., Fleischer, K., Jelinek, T., Mühlberger, N., Harms, G., Corachán, M., Grobusch, M. P., Knobloch, J., Bronner, U., Laferl, H., Kapaun, A., Bisoffi, Z., Clerinx, J., Puente, S., Fry, G., Schulze, M., Hellgren, U., Gjørup, I., Chalupa, P., Hatz, C., Matteelli, A., Schmid, M., Nielsen, L. N., da Cunha, S., Atouguia, J., Myrvang, B., and Fleischer, K.
Abstract: Travelers have the potential both to acquire and to spread dengue virus infection. The incidence of dengue fever (DF) among European travelers certainly is underestimated, because few centers use standardized diagnostic procedures for febrile patients. In addition, DF is currently not reported in most European public health systems. Surveillance has commenced within the framework of a European Network on Imported Infectious Disease Surveillance (TropNetEurop) to gain information on the quantity and severity of cases of dengue imported into Europe. Descriptions of 294 patients with DF were analyzed for epidemiological information and clinical features. By far the most infections were imported from Asia, which suggests a high risk of DF for travelers to that region. Dengue hemorrhagic fever occurred in 7 patients (2.4%) all of whom recovered. Data reported by member sites of the TropNetEurop can contribute to understanding the epidemiology and clinical characteristics of imported DF

26. Imported Falciparum Malaria in Europe: Sentinel Surveillance Data from the European Network on Surveillance of Imported Infectious Diseases

Author: Jelinek, T., Schulte, C., Behrens, R., Grobusch, M. P., Coulaud, J. P., Bisoffi, Z., Matteelli, A., Clerinx, J., Corachán, M., Puente, S., Gjørup, I., Harms, G., Kollaritsch, H., Kotlowski, A., Björkmann, A., Delmont, J. P., Knobloch, J., Nielsen, L. N., Cuadros, J., Hatz, C., Beran, J., Schmid, M. L., Schulze, M., Lopez-Velez, R., Fleischer, K., Kapaun, A., McWhinney, P., Kern, P., Atougia, J., Fry, G., da Cunha, S., Boecken, G., Jelinek, T., Schulte, C., Behrens, R., Grobusch, M. P., Coulaud, J. P., Bisoffi, Z., Matteelli, A., Clerinx, J., Corachán, M., Puente, S., Gjørup, I., Harms, G., Kollaritsch, H., Kotlowski, A., Björkmann, A., Delmont, J. P., Knobloch, J., Nielsen, L. N., Cuadros, J., Hatz, C., Beran, J., Schmid, M. L., Schulze, M., Lopez-Velez, R., Fleischer, K., Kapaun, A., McWhinney, P., Kern, P., Atougia, J., Fry, G., da Cunha, S., and Boecken, G.
Abstract: Malaria continues to have a high morbidity rate associated among European travelers. Thorough recording of epidemiological and clinical aspects of imported malaria has been helpful in the detection of new outbreaks and areas of developing drug resistance. Sentinel surveillance of data collected prospectively since 1999 has begun within TropNetEurop, a European network focusing on imported infectious diseases. TropNetEurop appears to cover ∼10% of all patients with malaria seen in Europe. Reports of 1659 immigrants and European patients with Plasmodium falciparum malaria were analyzed for epidemiological information and data on clinical features. Regional data were quite diverse, reflecting local patterns of immigration and international travel. By far, the most infections were imported from West Africa. Europeans had more clinical complications; consequently, all deaths occurred in this group. Compared with European standards, the mortality rate was low (0.6% in Europeans). Data from TropNetEurop member sites can contribute to our understanding of the epidemiological and clinical findings regarding imported falciparum malaria

27. The effect of short-course gentamicin therapy on kidney function in patients with bacteraemia-a retrospective cohort study.

Author: Carlsen S, Boel J, Jarløv JO, Gjørup I, Søborg C, and Arpi M
Subjects: Acute Kidney Injury etiology, Acute Kidney Injury mortality, Adolescent, Adult, Aged, Aged, 80 and over, Bacteremia complications, Bacteremia mortality, Denmark epidemiology, Female, Gentamicins adverse effects, Humans, Incidence, Kidney physiology, Logistic Models, Male, Middle Aged, Odds Ratio, Proportional Hazards Models, Renal Insufficiency etiology, Retrospective Studies, Risk Factors, Young Adult, Bacteremia drug therapy, Gentamicins therapeutic use, Kidney drug effects, Kidney Function Tests
Abstract: The nephrotoxic potential of aminoglycosides is primarily correlated to the duration of therapy. However, there are discrepancies between previous studies regarding the effect of short course treatment. The aim of this study was to compare renal function, renal recovery and mortality in a large cohort of patients with bacteraemia, who were empirically treated with regimens with and without a short course (≤ 3 days) of once daily dosing of gentamicin. This was a retrospective propensity score-matched cohort study based on all patients with bacteraemia in a Danish hospital in the period 2010-2013. We included 702 patients who received gentamicin, and 702 who did not receive gentamicin. To determine the impact of gentamicin on renal function, we used a modified version of the Kidney Disease: Improving Global Outcomes (KDIGO) criteria for acute kidney injury (AKI), and the resulting data were analyzed by logistic regression. We used Cox regression analysis to compare the adjusted mortality rates between the two groups. According to the KDIGO criteria, we found no significant difference in the occurrence of AKI between the two groups (odds ratio (OR) 0.90 (95% CI 0.68-1.20)). We found that recovery of renal function was similar in the two groups, OR 1.00 (95% CI 0.63-1.60). The hazard ratio for 90-day all-cause mortality was 1.02 (95% CI 0.84-1.25). Short-course empirical gentamicin treatment of patients with bacteraemia was not associated with an increased incidence of AKI nor all-cause mortality in this study, and we observed similar reversibility of renal function.
Published: 2018
Full Text: View/download PDF

28. Impact of antibiotic restriction on resistance levels of Escherichia coli: a controlled interrupted time series study of a hospital-wide antibiotic stewardship programme.

Author: Boel J, Andreasen V, Jarløv JO, Østergaard C, Gjørup I, Bøggild N, and Arpi M
Subjects: Hospitals, University, Humans, Interrupted Time Series Analysis, Retrospective Studies, Anti-Bacterial Agents therapeutic use, Drug Resistance, Bacterial, Drug Utilization, Escherichia coli drug effects, Health Policy
Abstract: Objectives: We evaluated the effect of an antibiotic stewardship programme (ASP) on the use of antibiotics and resistance levels of Escherichia coli using a method that allowed direct comparison between an intervention hospital and a control hospital., Methods: The study was conducted as a retrospective controlled interrupted time series (ITS) at two university teaching hospitals, intervention and control, with 736 and 552 beds, respectively. The study period was between January 2008 and September 2014. We used ITS analysis to determine significant changes in antibiotic use and resistance levels of E. coli. Results were directly compared with data from the control hospital utilizing a subtracted time series (STS)., Results: Direct comparison with the control hospital showed that the ASP was associated with a significant change in the level of use of cephalosporins [-151 DDDs/1000 bed-days (95% CI -177, -126)] and fluoroquinolones [-44.5 DDDs/1000 bed-days (95% CI -58.9, -30.1)]. Resistance of E. coli showed a significant change in slope for cefuroxime [-0.13 percentage points/month (95% CI -0.21, -0.057)] and ciprofloxacin [-0.15 percentage points/month (95% CI -0.26, -0.038)]., Conclusions: The ASP significantly reduced the use of cephalosporins and fluoroquinolones, with concomitant decreasing levels of E. coli resistance to cefuroxime and ciprofloxacin. The same development was not observed at the control hospital., (© The Author 2016. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.)
Published: 2016
Full Text: View/download PDF

29. [Antibiotic stewardship has been established at Herlev Hospital].

Author: Arpi M, Gjørup I, Boel JB, Bøggild N, Hansen SW, and Jarløv JO
Subjects: Anti-Bacterial Agents therapeutic use, Cephalosporins administration & dosage, Cephalosporins therapeutic use, Clostridium Infections epidemiology, Clostridium Infections prevention & control, Cross Infection prevention & control, Drug Utilization Review, Hospitals standards, Humans, Medical Audit, Practice Guidelines as Topic, Practice Patterns, Physicians', Quinolones administration & dosage, Quinolones therapeutic use, Anti-Bacterial Agents administration & dosage, Antimicrobial Stewardship, Drug Prescriptions standards, Drug Prescriptions statistics & numerical data
Abstract: A high incidence of Clostridium difficile and multiresistant organisms and increasing consumption of cephalosporins and quinolones have required an antibiotic stewardship programme, and antibiotic audits with feedback, revised guidelines and stringent prescription rules have been successful. The hospital intervention was managed by an antibiotic team combined with contact persons in all departments, a pocket edition of the guideline was available, and monthly commented reports about antibiotic consumption in each department were presented on the intranet. Significant declining use of restricted antibiotics was observed.
Published: 2014

30. [Clostridium difficile ribotype 027 is a challenge].

Author: Sommer TN, Ravn P, and Gjørup I
Subjects: Aged, Aged, 80 and over, Anti-Bacterial Agents therapeutic use, Cross Infection epidemiology, Denmark epidemiology, Diarrhea microbiology, Disease Outbreaks, Feces microbiology, Female, Hospitals statistics & numerical data, Humans, Male, Middle Aged, Recurrence, Retrospective Studies, Ribotyping, Clostridioides difficile isolation & purification, Clostridium Infections epidemiology
Abstract: Infection with Clostridium difficile is the primary infective cause of antibiotic-associated diarrhoea. In 2008, a major outbreak of CD027 took place in North Zealand, Denmark. We described this infection in a single medical department. Patients positive for C. difficile enlisted at Medical Department O, Herlev Hospital, in 2009 were included and demographic data were recorded. In total, 69 patients were included, average age 83 years, Charlson Comorbidity Score 4. Of all patients 24 died. Further studies are needed in order to treat and minimize infection with C. difficile.
Published: 2014

31. [Picture of the month: tuberculosis].

Author: Glintborg B, Hvidberg S, Gjørup I, and Grossmann E
Subjects: Antibodies, Monoclonal administration & dosage, Antibodies, Monoclonal adverse effects, Antirheumatic Agents administration & dosage, Antirheumatic Agents adverse effects, Humans, Immunocompromised Host, Infliximab, Male, Middle Aged, Opportunistic Infections complications, Radiography, Tuberculosis, Pulmonary complications, Tuberculosis, Pulmonary immunology, Tuberculosis, Pulmonary diagnostic imaging
Published: 2009

32. [Severe Haemophilus influenzae b infection in healthy male adult].

Author: Vilmar AC, Gjørup I, and David K
Subjects: Acute Kidney Injury diagnosis, Acute Kidney Injury etiology, Amputation, Surgical, Disseminated Intravascular Coagulation diagnosis, Disseminated Intravascular Coagulation etiology, Haemophilus Infections complications, Haemophilus Infections drug therapy, Haemophilus influenzae type b isolation & purification, Humans, Leg surgery, Male, Meningitis, Haemophilus complications, Meningitis, Haemophilus diagnosis, Meningitis, Haemophilus drug therapy, Middle Aged, Risk Factors, Haemophilus Infections diagnosis
Abstract: Haemophilus influenzae b (Hib) can be the cause of serious infections, and is mainly observed affecting children and immuno-compromised patients. We report a case of a healthy 49-year old male with a severe Hib infection complicated by septicaemia, meningitis and anuria. The risk of invasive Hib infections in adults is reviewed.
Published: 2008

33. Should hepatitis B vaccination be introduced into childhood immunisation programmes in northern Europe?

Author: Zuckerman J, van Hattum J, Cafferkey M, Gjørup I, Hoel T, Rummukainen ML, and Weiland O
Subjects: Child, Europe epidemiology, Health Policy, Hepatitis B epidemiology, Hepatitis B immunology, Humans, Incidence, Risk Assessment, Hepatitis B prevention & control, Mass Vaccination legislation & jurisprudence, Mass Vaccination statistics & numerical data, National Health Programs
Abstract: Infection with hepatitis B causes between 500,000 and 1.2 million deaths per year worldwide, and is the leading cause of liver cancer. Over 12 years ago, WHO recommended that universal childhood hepatitis B vaccination be implemented globally. Despite this, Denmark, Finland, Iceland, Ireland, the Netherlands, Norway, Sweden, and the UK have yet to implement such a policy and instead currently adopt an "at-risk" strategy. Although all eight countries are classed as having low endemicity, factors such as increased travel and integration of immigrant communities are increasing the number of at-risk individuals in these countries. Considering the difficulty in identifying all at-risk individuals, and the lack of effectiveness of at-risk vaccination on reducing the overall incidence of hepatitis B, we recommend that these countries reassess their hepatitis B prevention strategies. Universal vaccination against hepatitis B is the only way to eliminate the major public-health impact of this disease.
Published: 2007
Full Text: View/download PDF

34. Severe dengue virus infection in travelers: risk factors and laboratory indicators.

Author: Wichmann O, Gascon J, Schunk M, Puente S, Siikamaki H, Gjørup I, Lopez-Velez R, Clerinx J, Peyerl-Hoffmann G, Sundøy A, Genton B, Kern P, Calleri G, de Górgolas M, Mühlberger N, and Jelinek T
Subjects: Adolescent, Adult, Aged, Antibodies, Viral blood, Blood Chemical Analysis, Child, Dengue blood, Dengue diagnosis, Dengue Virus genetics, Dengue Virus immunology, Dengue Virus isolation & purification, Europe epidemiology, Female, Geography, Hemorrhage virology, Hospitalization, Humans, Immunoglobulin G blood, Immunoglobulin M blood, Male, Middle Aged, Risk Factors, Severe Dengue epidemiology, Severe Dengue physiopathology, Dengue epidemiology, Dengue physiopathology, Population Surveillance, Travel
Abstract: Background: Dengue fever is the most common arboviral disease in travelers. In countries where dengue virus is endemic, sequential (secondary) infections with different dengue virus serotypes are associated with disease severity. Data on severity and secondary infection rates in a population of travelers are lacking., Methods: Intensified surveillance of dengue fever in travelers was performed within the European Network on Surveillance of Imported Infectious Diseases. Data were collected at 14 European clinical referral centers between 2003 and 2005., Results: A total of 219 dengue virus infections imported from various regions of endemicity were reported. Serological analysis revealed a secondary immune response in 17%. Spontaneous bleeding was observed in 17 (8%) patients and was associated with increased serum alanine and aspartate aminotransferase levels and lower median platelet counts. Two (0.9%) patients fulfilled the World Health Organization (WHO) case definition for dengue hemorrhagic fever. However, 23 (11%) travelers had severe clinical manifestations (internal hemorrhage, plasma leakage, shock, or marked thrombocytopenia). A secondary immune response was significantly associated with both spontaneous bleeding and other severe clinical manifestations., Conclusions: In travelers, severe dengue virus infections are not uncommon but may be missed if the WHO classification is strictly applied. High liver enzyme levels and low platelet counts could serve as indicators of disease severity.
Published: 2007
Full Text: View/download PDF

35. Molecular surveillance of the antifolate-resistant mutation I164L in imported African isolates of Plasmodium falciparum in Europe: sentinel data from TropNetEurop.

Author: Wichmann O, Jelinek T, Peyerl-Hoffmann G, Mühlberger N, Grobusch MP, Gascon J, Matteelli A, Hatz C, Laferl H, Schulze M, Burchard G, da Cunha S, Beran J, McWhinney P, Kollaritsch H, Kern P, Cuadros J, Alifrangis M, and Gjørup I
Subjects: Amino Acid Substitution genetics, Animals, Humans, Isoleucine genetics, Leucine genetics, Malaria, Falciparum diagnosis, Malaria, Falciparum epidemiology, Malaria, Falciparum genetics, Malaria, Falciparum metabolism, Plasmodium falciparum isolation & purification, Drug Resistance, Multiple genetics, Folic Acid Antagonists metabolism, Plasmodium falciparum drug effects, Plasmodium falciparum genetics, Population Surveillance
Abstract: Background: Malaria parasites that carry the DHFR-mutation I164L are not only highly resistant to sulfadoxine-pyrimethamine but also to the new antimalarial drug chlorproguanil-dapsone. The spread of this mutation in Africa would result in a public health disaster since there is a lack of effective alternatives that are both affordable and safe. Up to now, this mutation has only been described in Asian and Latin-American countries. The objective of this study was to assess the prevalence of this mutation in African isolates of Plasmodium falciparum that have been imported into Europe through travellers., Methods: TropNetEurop is a network for the surveillance of travel-associated diseases and seems to cover approximately 12% of all malaria cases imported into Europe. Within this network we screened 277 imported African isolates of P. falciparum with the help of PCR- and enzyme-digestion-methods for the antifolate-resistant mutation I164L., Results: The I164L mutation was not detected in any of the isolates tested., Discussion: Continuous molecular surveillance of mutations in P. falciparum, as it is practised within TropNetEurop, is an essential tool for the understanding and early detection of the spread of antimalarial drug resistance in Africa.
Published: 2003
Full Text: View/download PDF

36. Molecular surveillance of drug resistance through imported isolates of Plasmodium falciparum in Europe.

Author: Jelinek T, Peyerl-Hoffmann G, Mühlberger N, Wichmann O, Wilhelm M, Schmider N, Grobusch MP, von Sonnenburg F, Gascon J, Laferl H, Hatz C, Alifrangis M, Burchard G, McWhinney P, Schulze M, Kollaritsch H, da Cunha S, Beran J, Kern P, Gjørup I, and Cuadros J
Subjects: Animals, Chloroquine pharmacology, Codon, Dihydropteroate Synthase genetics, Drug Resistance, Multiple genetics, Europe, Folic Acid Antagonists pharmacology, Humans, Malaria, Falciparum parasitology, Membrane Transport Proteins, Plasmodium falciparum genetics, Plasmodium falciparum isolation & purification, Point Mutation, Tetrahydrofolate Dehydrogenase genetics, Travel, ATP-Binding Cassette Transporters genetics, Antimalarials pharmacology, Drug Resistance genetics, Membrane Proteins genetics, Plasmodium falciparum drug effects, Protozoan Proteins genetics
Abstract: Background: Results from numerous studies point convincingly to correlations between mutations at selected genes and phenotypic resistance to antimalarials in Plasmodium falciparum isolates. In order to move molecular assays for point mutations on resistance-related genes into the realm of applied tools for surveillance, we investigated a selection of P. falciparum isolates that were imported during the year 2001 into Europe to study the prevalence of resistance-associated point mutations at relevant codons. In particular, we tested for parasites which were developing resistance to antifolates and chloroquine. The screening results were used to map the prevalence of mutations and, thus, levels of potential drug resistance in endemic areas world-wide., Results: 337 isolates have been tested so far. Prevalence of mutations that are associated with resistance to chloroquine on the pfcrt and pfmdr genes of P. falciparum was demonstrated at high levels. However, the prevalence of mutations associated with resistance to antifolates at the DHFR and DHPS genes was unexpectedly low, rarely exceeding 60% in endemic areas., Conclusions: Constant screening of imported isolates will enable TropNetEurop to establish a screening tool for emerging resistance in endemic areas.
Published: 2002
Full Text: View/download PDF

37. Imported Falciparum malaria in Europe: sentinel surveillance data from the European network on surveillance of imported infectious diseases.

Author: Jelinek T, Schulte C, Behrens R, Grobusch MP, Coulaud JP, Bisoffi Z, Matteelli A, Clerinx J, Corachán M, Puente S, Gjørup I, Harms G, Kollaritsch H, Kotlowski A, Björkmann A, Delmont JP, Knobloch J, Nielsen LN, Cuadros J, Hatz C, Beran J, Schmid ML, Schulze M, Lopez-Velez R, Fleischer K, Kapaun A, McWhinney P, Kern P, Atougia J, Fry G, da Cunha S, and Boecken G
Subjects: Adolescent, Adult, Africa epidemiology, Aged, Aged, 80 and over, Child, Child, Preschool, Communicable Diseases epidemiology, Communicable Diseases transmission, Europe epidemiology, Humans, Infant, Malaria, Falciparum mortality, Malaria, Falciparum transmission, Middle Aged, Morbidity, Travel, Malaria, Falciparum epidemiology, Sentinel Surveillance
Abstract: Malaria continues to have a high morbidity rate associated among European travelers. Thorough recording of epidemiological and clinical aspects of imported malaria has been helpful in the detection of new outbreaks and areas of developing drug resistance. Sentinel surveillance of data collected prospectively since 1999 has begun within TropNetEurop, a European network focusing on imported infectious diseases. TropNetEurop appears to cover approximately 10% of all patients with malaria seen in Europe. Reports of 1659 immigrants and European patients with Plasmodium falciparum malaria were analyzed for epidemiological information and data on clinical features. Regional data were quite diverse, reflecting local patterns of immigration and international travel. By far, the most infections were imported from West Africa. Europeans had more clinical complications; consequently, all deaths occurred in this group. Compared with European standards, the mortality rate was low (0.6% in Europeans). Data from TropNetEurop member sites can contribute to our understanding of the epidemiological and clinical findings regarding imported falciparum malaria.
Published: 2002
Full Text: View/download PDF

38. [Malaria. An evaluation of 127 patients treated in Rigshospitalet in 1999 and 2000].

Author: Gjørup IE
Subjects: Adult, Antimalarials administration & dosage, Denmark epidemiology, Denmark ethnology, Female, Humans, Malaria drug therapy, Malaria ethnology, Malaria, Falciparum drug therapy, Malaria, Falciparum epidemiology, Malaria, Falciparum ethnology, Malaria, Vivax drug therapy, Malaria, Vivax epidemiology, Malaria, Vivax ethnology, Male, Middle Aged, Retrospective Studies, Travel, Malaria epidemiology
Abstract: Introduction: The incidence of malaria has increased globally to 500 million cases a year. Imported malaria in travellers comprises only a small fraction, but the disease has become a serious problem in Europe and the United States. The aim of the present study was to elucidate the epidemiological and clinical aspects of patients with imported malaria in Denmark., Material and Methods: All patients treated for malaria at the Department of Infectious Diseases, Rigshospitalet, in 1999-2000 were evaluated retrospectively. Age, sex, nationality, destination, chemoprophylaxis, symptoms, duration of symptoms, parasitaemia, treatment, and complications were registered., Results: Seventy per cent of the patients had falciparum malaria. Of these, 95% had been infected in Africa and 46% of these patients were Africans living in Denmark. Only 50% of all patients had been taking chemoprophylaxis and of these only half had been compliant. Chloroquine and proguanile were most commonly used. Seven patients had parasitaemia above 5%, but only one of these developed complicated malaria., Discussion: The risk of complicated malaria in this series was low and seems to be related to lack of chemoprophylaxis, advanced age, and duration of symptoms.
Published: 2001

39. [Eosinophilia among immigrants].

Author: Gjørup IE
Subjects: Denmark epidemiology, Diagnosis, Differential, Eosinophilia diagnosis, Eosinophilia ethnology, Eosinophilia etiology, Humans, Parasitic Diseases diagnosis, Parasitic Diseases ethnology, Emigration and Immigration, Eosinophilia epidemiology, Parasitic Diseases epidemiology, Refugees
Published: 2000

40. [Travel prophylaxis among immigrants].

Author: Gjørup IE
Subjects: Adult, Antimalarials administration & dosage, Denmark, Female, Humans, Infant, Malaria, Falciparum prevention & control, Malaria, Falciparum transmission, Preventive Health Services, Emigration and Immigration, Endemic Diseases prevention & control, Travel
Abstract: A female immigrant and her child acquired Plasmodium falciparum infection during a visit to her home country. They did not receive chemoprophylaxis during or after the journey. Immigrants comprise a high risk group for malaria as well as typhoid fever and hepatitis A. Increased attention towards this group of travellers is recommended.
Published: 2000

41. Dependency of cerebral blood flow on mean arterial pressure in patients with acute bacterial meningitis.

Author: Møller K, Larsen FS, Qvist J, Wandall JH, Knudsen GM, Gjørup IE, and Skinhøj P
Subjects: Acute Disease, Adult, Aged, Aged, 80 and over, Blood Pressure drug effects, Cerebrovascular Circulation drug effects, Combined Modality Therapy, Female, Homeostasis drug effects, Homeostasis physiology, Humans, Linear Models, Male, Meningitis, Bacterial therapy, Middle Aged, Norepinephrine, Prospective Studies, Statistics, Nonparametric, Treatment Outcome, Vasoconstrictor Agents, Blood Pressure physiology, Cerebrovascular Circulation physiology, Meningitis, Bacterial physiopathology
Abstract: Objective: Patients with acute bacterial meningitis are often treated with sympathomimetics to maintain an adequate mean arterial pressure (MAP). We studied the influence of such therapy on cerebral blood flow (CBF)., Design: Prospective physiologic trial., Setting: The Department of Infectious Diseases, Copenhagen University Hospital, Denmark., Patients: Sixteen adult patients with acute bacterial meningitis., Intervention: Infusion of norepinephrine to increase MAP., Measurements: During a rise in MAP induced by norepinephrine infusion, we measured relative changes in CBF by transcranial Doppler ultrasonography of the middle cerebral artery, recording mean flow velocity (Vmean), and by the arterial to jugular oxygen saturation difference. In 10 out of 16 patients, serial measurements were performed until recovery or death. Individual autoregulation curves were analyzed by a computer program. Autoregulation was classified as impaired if Vmean increased by >10% per 30 mm Hg increase in MAP and if no lower limit of autoregulation was identified by the computer program; otherwise, autoregulation was classified as preserved., Main Results: Initially, Vmean increased from a median value of 46 cm/sec (range, 30-87 cm/sec) to 63 cm/sec (33-105 cm/sec) (p < .0001), and arterial to jugular oxygen saturation difference decreased from 0.28 (0.16-0.51) to 0.21 (0.08-0.39) (p < .001) when MAP was raised from 69 mm Hg (55-102 mm Hg) to 110 mm Hg (93-129 mm Hg). CBF autoregulation was restored in eight of ten patients undergoing serial examination after 7 (range, 2-10) days. Six of these patients had an uncomplicated course, one had a protracted recovery, and one died. Autoregulation was not restored in two patients; one died and one had a protracted recovery., Conclusion: In patients in the early phase of acute bacterial meningitis, CBF autoregulation is impaired. With recovery from meningitis, the cerebral vasculature regains the ability to maintain cerebral perfusion at a constant level despite variations in MAP.
Published: 2000
Full Text: View/download PDF

42. [Randomized trial and meta-analysis of somatostatin versus placebo in bleeding esophageal varices].

Author: Gøtzsche PC, Gjørup IE, Bonnén H, Brahe NE, Becker PU, and Burcharth F
Subjects: Aged, Female, Gastrointestinal Agents therapeutic use, Humans, Male, Middle Aged, Octreotide therapeutic use, Esophageal and Gastric Varices drug therapy, Gastrointestinal Hemorrhage drug therapy, Hormone Antagonists therapeutic use, Neurotransmitter Agents therapeutic use, Somatostatin therapeutic use
Abstract: We studied whether somatostatin or its derivative, octreotide, is more effective than placebo in the treatment of bleeding oesophageal varices in a randomised, double-blind trial and a meta-analysis with blinded data analysis and manuscript writing. Patients suspected of bleeding from oesophageal varices and of having cirrhosis of the liver were eligible. Eighty-six patients were randomised; 16 died in each group within six weeks (95% confidence interval (CI) for difference in mortality -19% to 22%). There were no differences between somatostatin and placebo in median number of blood transfusions (8 vs 5, p = 0.07, CI 0 to 4 transfusions) or in numbers of patients who needed balloon tamponade (16 vs 13, p = 0.54, CI -11% to 28%). In a meta-analysis of three trials, involving 290 patients, somatostatin had no effect on survival compared with placebo (p = 0.59, odds ratio 1.16, CI 0.67 to 2.01). For blood transfusions and use of balloon tamponade there was heterogeneity between the trials with no convincing evidence in favour of somatostatin.
Published: 1996

43. Somatostatin v placebo in bleeding oesophageal varices: randomised trial and meta-analysis.

Author: Gøtzsche PC, Gjørup I, Bonnén H, Brahe NE, Becker U, and Burcharth F
Subjects: Aged, Balloon Occlusion, Blood Transfusion, Catheterization, Double-Blind Method, Emergencies, Esophageal and Gastric Varices therapy, Female, Gastrointestinal Hemorrhage therapy, Humans, Male, Middle Aged, Placebos, Survival Analysis, Esophageal and Gastric Varices drug therapy, Gastrointestinal Hemorrhage drug therapy, Octreotide therapeutic use, Somatostatin therapeutic use
Abstract: Objective: To study whether somatostatin or its derivative octreotide is more effective than placebo for treating bleeding oesophageal varices., Methods: Randomised, double blind trial and meta-analysis with blinded analysis of data and writing of manuscripts., Setting: Departments of medical and surgical gastroenterology in Copenhagen., Subjects: Patients suspected of bleeding from oesophageal varices and of having cirrhosis of the liver., Main Outcome Measures: Survival, number of blood transfusions, and use of Sengstaken-Blakemore tube., Results: 86 patients were randomised; in each group 16 died within six weeks (95% confidence interval for difference in mortality--19% to 22%). There were no differences between those treated with somatostatin or placebo in median number of blood transfusions (8 v 5, P = 0.07, 0 to 4 transfusions) or in numbers of patients who needed balloon tamponade (16 v 13, P = 0.54, -11% to 28%). In a meta-analysis of three trials involving 290 patients somatostatin had no effect on survival compared with placebo (P = 0.59, odds ratio 1.16; 0.67 to 2.01). For blood transfusions and use of balloon tamponade there was heterogeneity between the trials with no convincing evidence in favour of somatostatin. No placebo controlled trials have been performed with octreotide., Conclusion: Within the limited power of this study and meta-analysis we were unable to show a clinical benefit of somatostatin in the emergency treatment of bleeding oesophageal varices.
Published: 1995
Full Text: View/download PDF

44. [Collagenous colitis].

Author: Jarløv AE, Gjørup IE, and Thomsen OO
Subjects: Aged, Chronic Disease, Colitis complications, Colitis metabolism, Diagnosis, Differential, Diarrhea diagnosis, Diarrhea etiology, Female, Humans, Intestinal Mucosa pathology, Middle Aged, Colitis pathology, Collagen metabolism
Abstract: Collagenous colitis was first described in 1976 by Lindström as an unusual cause of persistent, watery diarrhea. He noted a large subepithelial band of collagen deposited in the rectum and the colon. Collagenous colitis occurs predominantly in females and is more frequent in the elderly. Radiographic examination of the colon is unremarkable, and the patients show no signs of malabsorption. The diagnosis requires biopsy specimens from the colon, as the disease is focal and less frequently affects the rectum. Biopsies taken only from the rectum cannot exclude the diagnosis. For the time being there is no consensus as to the treatment of the disease. We describe two patients with collagenous colitis successfully treated with prednisolone. The diagnostic importance of total colonoscopy with multiple biopsies in a normal-appearing colon in patients with unexplained chronic watery diarrhea is stressed.
Published: 1994

45. A double-blinded multicenter trial of somatostatin in the treatment of acute pancreatitis.

Author: Gjørup I, Roikjaer O, Andersen B, Burcharth F, Hovendal C, Pedersen SA, Christiansen P, Wara P, Andersen JC, and Balslev I
Subjects: Acute Disease, Adult, Amylases blood, Amylases drug effects, Double-Blind Method, Female, Humans, Male, Middle Aged, Pancreatitis blood, Somatostatin pharmacology, Pancreatitis drug therapy, Somatostatin therapeutic use
Abstract: To evaluate the effect of somatostatin in the treatment of acute pancreatitis, 63 patients were randomly allocated to continuous intravenous infusion for three days of 250 micrograms of somatostatin (Dura Scan, Odense, Denmark) per hour (n = 33), or placebo (n = 30). Patients with a first attack of pancreatitis, serum amylase level of more than 450 units per liter and symptoms for less than 24 hours were eligible for participation in the study. Apart from a slightly significant faster decrease in serum amylase concentrations, we were unable to demonstrate any significant benefit from somatostatin with regard to paraclinical values and clinical course.
Published: 1992

46. Development of stress ulcers assessed by gastric electrical potential difference, pH of gastric juice, and endoscopy in patients in the intensive care unit.

Author: Rubinstein E, Gjørup I, Schulze S, Jonsson T, and Højgaard L
Subjects: Adult, Aged, Case-Control Studies, Female, Gastric Acidity Determination, Gastroscopy, Humans, Hydrogen-Ion Concentration, Intensive Care Units, Male, Membrane Potentials physiology, Middle Aged, Stomach Ulcer etiology, Stress, Physiological complications, Gastric Acid physiology, Stomach Ulcer physiopathology, Stress, Physiological physiopathology
Abstract: Objective: To assess measurement of gastric electrical potential difference, pH of gastric mucosa, and endoscopic findings in patients in intensive care units who are at risk of developing stress ulcers., Design: Open comparison with age- and sex-matched control subjects., Setting: Herlev Hospital, Denmark., Subjects: Sixteen consecutive patients with no history of gastrointestinal haemorrhage, coagulopathy, or ulcer disease who had been admitted to the intensive care unit, and 16 age- and sex-matched outpatients with normal endoscopic findings., Interventions: Upper gastrointestinal endoscopy, during which any lesions that were found were scored according to severity, the gastric potential difference, and the pH of gastric juice were measured., Outcome Measures: Correlation between the incidence of stress ulceration found at endoscopy, gastric potential difference, and gastric pH., Results: Gastric potential difference was significantly reduced and gastric pH significantly increased in the patients in the intensive care unit (p less than 0.05 in both cases), all of whom had stress ulcers in more than one gastric segment. Nine of the patients had gastric pH readings of greater than 4., Conclusion: Gastric electrical potential difference may be useful measurement for the assessment of stress ulceration in patients in intensive care units.
Published: 1992

47. Surgical treatment of morbid obesity. A survey of overall outcome 1968-1989.

Author: Gjørup IE, Gøtzsche PC, Baden H, and Andersen B
Subjects: Female, Follow-Up Studies, Gastric Bypass adverse effects, Gastroplasty adverse effects, Humans, Jejunoileal Bypass adverse effects, Male, Patient Satisfaction, Weight Loss, Obesity, Morbid surgery
Abstract: This survey evaluates benefits and costs from a policy of employing surgical treatment in selected cases of morbid obesity. Between 1968 and 1978, we used end-to-side jejunoileal bypass. Despite many satisfied patients, complications were frequent and severe. For the next decade, we employed various types of gastric surgery. We eventually assessed a gastric balloon, but without success. Median duration of follow-up was 132 months in 145 patients with jejunoileostomy, 103 months in seven gastric bypass patients, and 36 months in 108 gastroplasty patients. Three patients were lost to follow-up. There have been four deaths after intestinal shunt and one after gastroplasty. The median re-admission rate was 1.6 per patient, while the median number of re-operations was 2.0 after intestinal shunt and 0.8 after gastric interventions. The median weight loss in our 260 patients was 32.1% of the preoperative weight. Outcome was good in 38.8%, acceptable in 40.4% and poor in 11.5% while there were 9.2% failures. Truly satisfactory outcomes, however, were rare, owing possibly to a negative relationship between weight loss and complications. Only 8.8% have obtained a stable normal weight without any side-effects.
Published: 1991

48. [Are prescribed cloth corsets used by patients? A questionnaire study].

Author: Bugge PM, Gjørup IE, and Gjørup L
Subjects: Adult, Aged, Denmark, Follow-Up Studies, Humans, Middle Aged, Surveys and Questionnaires, Braces standards, Orthopedic Equipment statistics & numerical data
Published: 1984

49. [The effects of ingestion of moderate quantities of liquorice].

Author: Gøtzsche PC and Gjørup IE
Subjects: Adult, Clinical Trials as Topic, Edema etiology, Female, Gastrointestinal Diseases etiology, Headache etiology, Humans, Male, Middle Aged, Species Specificity, Glycyrrhiza, Plants, Medicinal
Published: 1983

Catalog

Books, media, physical & digital resources

See catalog results

Searchworks

Select search scope, currently: Articles Catalog books, media & more in Jio Institute collections Articles journal articles & other e-resources

Search

Search Constraints

Refine your results

Search Limiters

Topic

Publication Year Range

Language

Publication Type

Journal

Region

Database

Publisher

49 results on '"Gjørup, I"'

Search Results

Catalog

Select search scope, currently: Articles

Catalog

books, media & more in Jio Institute collections

Articles

journal articles & other e-resources