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Rahel Dereje,1,2 Kalkidan Hassen,1 Getu Gizaw1 1Department of Nutrition and Dietetics, Institute of Health Science, Faculty of Public Health, Jimma University, Jimma, Ethiopia; 2School of Public Health, College of Medicine and Health Science, Mizan Tepi University, Mizan Aman, EthiopiaCorrespondence: Rahel Dereje Email raheldereje3@gmail.comBackground: Globally, hypertension is becoming a serious problem affecting the health and wellbeing of the adult population. Anthropometric indices like body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR) have long been utilized to screen hypertension; in contrast, other evidence indicates the superior utility of waist-to-height ratio (WHtR) to screen hypertension. There are inconclusive results from different studies done in different settings regarding the best screening index for hypertension. In addition, there is a paucity of information on the evaluation of anthropometric indices for screening hypertension in the study area. Therefore, this study evaluates the utility of anthropometric indices for screening hypertension among Mizan Tepi University employees, southwestern Ethiopia.Methods: An institution-based cross-sectional study was conducted among Mizan Tepi University employees. A gender-based stratified simple random sampling technique was used to select 585 employees. Logistic regression analysis was conducted to assess the association between anthropometric indices and hypertension. Receiver operating characteristic curve (ROC) was employed to evaluate anthropometric indices for screening hypertension, and optimal cutoff points were also developed based on Youden index (sensitivity + specificity – 1) and presented with sensitivity, specificity, positive predictive value (PPV), and negative predictive values (NPV).Results: The overall prevalence of hypertension was 20.9%, which was 22.5% in males and 18.7% in females. Among males, WHtR, WHR, and BMI were significantly associated with hypertension, while, in females, only BMI was associated with hypertension. WHtR had a higher screening ability for hypertension followed by WC in both sexes. For males, the cutoff point for WHR, WC, BMI, and WHtR for screening hypertension was 0.897, 85.17cm, 24.6kg/m2, and 0.51, respectively. In females, the cutoff point developed for screening hypertension for WHR, WC, BMI, and WHtR were 0.92, 85.67cm, 24.8kg/m2, and 0.52, respectively.Conclusion: The waist-to-height ratio was found to be the best obesity index to screen hypertension than BMI, WC, and WHR. The finding supports the use of WHtR for screening hypertension in resource-limited settings.Keywords: obesity, WHtR, BMI, WHR, WC

Robel Hussen Kabthymer,1 Getu Gizaw,2 Tefera Belachew2 1Human Nutrition Unit, School of Public Health, Dilla University, Dilla, Ethiopia; 2Department of Population and Family Health, College of Health Sciences, Jimma University, Jimma, EthiopiaCorrespondence: Robel Hussen Kabthymer Tel +251913575702Email robelhussen@rocketmail.comPurpose: Treatment at a stabilization center is an important intervention to avert the huge burden of mortality for children with complicated severe acute malnutrition (SAM). Despite the improvement in hospital coverage and the development of standardized WHO treatment guidelines, recent reviews indicated a wide range in recovery rate (34– 88%) due to several context-specific factors. This study aimed to estimate time to recovery and to determine predictors of time to recovery among children aged 6– 59 months with severe acute malnutrition.Patients and Methods: An institution-based retrospective cohort study design was used among 375 children aged 6– 59 months admitted to Jimma University Medical Center, Jimma, Ethiopia from September 2015 to September 2017. All eligible children were enrolled and assessed using a pretested questionnaire. Kaplan–Meir estimates and survival curves were used to compare the time to recovery using log rank test among different characteristics. Cox proportional hazard model was used to identify significant predictors of time to recovery. A p-value less than 0.05 was declared statistically significant.Results: The rate of recovery was 4.06 per 100 person days. Median time of recovery for our cohort of SAM children’s was 19 days (95% CI: 17.95– 20.05). Independent predictors of time to recovery were play stimulation (AHR=1.93, 95% CI: 1.23– 3.03), vaccination status (AHR=2.26, 95% CI: 1.12– 4.57), tuberculosis (AHR= 0.48, 95% CI: 0.27– 0.87), malaria (AHR=0.34,95% CI:0.13– 0.88), use of amoxicillin (AHR=1.54, 95% CI: 0.008– 2.34), deworming (AHR=1.8, 95% CI: 1.18– 2.73), and shock (AHR=0.18, 95% CI: 0.05– 0.59).Conclusion: The findings of this study showed that the average length of stay on treatment and median time for recovery are within the sphere standard. Psychosocial stimulation, appropriate provision of routine medication and management of medical co-morbidity are needed to promote fast recovery.Keywords: retrospective cohort, predictors, recovery, severe acute malnutrition, Jimma

Abstract Lamb morbidity and mortality cause significant loss in a smallholder production system. A longitudinal prospective survey was conducted on 408 randomly selected farmers located in six purposefully selected kebeles in Gewata woreda from June 2020 to July 2021 to determine the incidence of morbidity and mortality in lambs and to identify risk factors. For this purpose, 408 lambs from the Gewata district’s mixed crop-livestock production system were examined every day from birth to three months of age. The data was analyzed using the Kaplan-Meier (K-M) method, the log-rank test, and Cox proportional hazards regression. Results showed that the cumulative incidence of all-cause of morbidity and mortality at the end of three month was 12.86% (95% CI: 10.26–16.13%), and 6.86% (95% CI: 5.03–9.35%), respectively. Diarrhea was the leading cause of morbidity and mortality, accounting for 49.33 and 50% morbidity and mortality, respectively. Pneumonia was the second most frequent cause of morbidity and death. In the K-M hazard analysis, the greatest risk of lamb morbidity and mortality was observed during the first month of life, and then the risk decreased significantly as the lamb grew. Of the 17 potential risk factors studied, the multivariable Cox proportional hazards regression model showed that lamb sex, birth weight, umbilical care, time and method of colostrum feeding were the five predictors that were significantly associated with a higher risk of morbidity, whereas birth weight, lambing difficulty, dams’ parity, method and time of colostrum feeding were the five predictors that were significantly associated with a higher risk of mortality. Moreover, a higher risk of morbidity was observed in lambs with methods of colostrum feeding after birth (HR = 3.158; p = 0.000) and with variations in birth weight (HR = 1.418; p = 0.003). Similarly, the mortality risk was 4.926 (p = 0.047), 4.023 (p = 0.012), and 3.206 (p = 0.000) times higher in lambs with lambing difficulties, at the time of colostrum feeding, and by the method of colostrum feeding, respectively. According to this research, lamb morbidity and mortality rates in the study area are significantly high which has a great impact on the replacement stock and production. Hence, awareness should be created among farmers concerning improved lamb management practices.

Abstracts Background Tele-pharmacy is a subset of telemedicine in which pharmacies use telecommunication technology to provide patient care. Tele-pharmacy can improve pharmaceutical care service delivery by reducing medication errors, improving access to health professionals and facilities in remote and rural areas, and minimizing adverse drug events. However, there is limited evidence regarding future pharmacists' knowledge and perceptions of the Tele-pharmacy system in Ethiopia. As a result, this study aimed to assess tele-Pharmacy perception, knowledge and associated factors among pharmacy students in Northwest Ethiopia. Methods An institutional-based cross-sectional study was conducted among 376 pharmacy students in Northwest Ethiopia between July 15 and August 27, 2022. A pre-tested self-administered questionnaire was used to collect data. The data were entered using Epi info version 7.0 and analyzed using SPSS version 25. Descriptive statistics, bivariable and multivariable logistic regression analysis were used to describe pharmacy students' knowledge and perceptions of Tele-pharmacy and identify associated factors. An adjusted odds ratio (OR) and a p-value with a 95% confidence interval (CI) were calculated to declare statistical significance. Results From a total of 352 participants, about 32.4% with [95% CI (27%-37%)] and 48.6% with [95% CI (43%—54%)] had good knowledge and a positive perception toward Tele-pharmacy, respectively. Being age group of 26–30 (AOR = 0.35, 95% CI: 0.17–0.68), being male (AOR = 2.38, 95% CI: 1.26–4.49), Having a CPGA of > 3.5 (AOR = 2.28, 95% CI: 1.24–4.19), Taking basic computer training (AOR = 2.00, 95% CI: 1.17–3.39), Management support (AOR = 1.84, 95% CI: 1.06–3.19) were found to be significantly associated with pharmacy students' knowledge of Tele-pharmacy. Similarly, having access to electronic devices (AOR = 3.80, 95% CI: 1.81–7.97), training related to pharmacy information systems (AOR = 6.66, 95% CI: 3.34–13.29), availability of guidelines (AOR = 2.99, 95% CI: 1.62–5.50) were found to be significantly associated with pharmacy students' perceptions of Tele-pharmacy. Conclusion This study found that pharmacy students have limited knowledge and perceptions of the Tele-pharmacy system. A continuing Tele-pharmacy training package, incorporating pharmacy information system guidelines as part of their education, and providing managerial support could be recommended to improve pharmacy students' knowledge and perception of Tele-pharmacy.

Background: Digital health is a new health field initiative. Health professionals require security in digital places because cybercriminals target health care professionals. Therefore, millions of medical records have been breached for money. Regarding digital security, there is a gap in studies in limited-resource countries. Therefore, surveying health professionals' attitudes toward digital health data security has a significant purpose for interventions., Objective: This study aimed to assess the attitudes of health professionals toward digital health data security and their associated factors in a resource-limited country., Methods: A cross-sectional study was conducted to measure health professionals' attitudes toward digital health data security. The sample size was calculated using a single population. A pretest was conducted to measure consistency. Binary logistic regression was used to identify associated factors. For multivariable logistic analysis, a P value ≤.20 was selected using Stata software (version 16; StataCorp LP)., Results: Of the total sample, 95% (402/423) of health professionals participated in the study. Of all participants, 63.2% (254/402) were male, and the mean age of the respondents was 34.5 (SD 5.87) years. The proportion of health professionals who had a favorable attitude toward digital health data security at specialized teaching hospitals was 60.9% (95% CI 56.0%-65.6%). Educational status (adjusted odds ratio [AOR] 3.292, 95% CI 1.16-9.34), basic computer skills (AOR 1.807, 95% CI 1.11-2.938), knowledge (AOR 3.238, 95% CI 2.0-5.218), and perceived usefulness (AOR 1.965, 95% CI 1.063-3.632) were factors associated with attitudes toward digital health data security., Conclusions: This study aimed to assess health professionals' attitudes toward digital health data security. Interventions on educational status, basic computer skills, knowledge, and perceived usefulness are important for improving health professionals' attitudes. Improving the attitudes of health professionals related to digital data security is necessary for digitalization in the health care arena., (© Ayenew Sisay Gebeyew, Zegeye Regasa Wordofa, Ayana Alebachew Muluneh, Adamu Ambachew Shibabaw, Agmasie Damtew Walle, Sefefe Birhanu Tizie, Muluken Belachew Mengistie, Mitiku Kassaw Takillo, Bayou Tilahun Assaye, Adualem Fentahun Senishaw, Gizaw Hailye, Aynadis Worku Shimie, Fikadu Wake Butta. Originally published in the Online Journal of Public Health Informatics (https://ojphi.jmir.org/).)

Good hand-washing practice is the most important preventive measure to reduce the spread of communicable disease to under-five children. Prior studies on good handwashing practice at critical times among mothers of children under-five age in Ethiopia were extremely varied. Therefore, this meta-analysis aimed to assess the overall proportion of good handwashing practice at critical times and identify the associated factors in Ethiopia. A comprehensive search of relevant studies was performed using distinct databases. Data were extracted using Microsoft Excel spreadsheet, and exported to Stata-MPv-17 for analysis. A random-effect model was used to estimate the overall proportion of good hand-washing practice at critical times. A random or fixed effects model was used to compute the pooled AORs with their 95% Cis, which were presented on a forest plot. I 2 test statistics was used for assessing heterogeneity among the included studies. The funnel plot and Egger's test were used to assess the publication bias. Ten studies were included in this systematic review and meta-analysis. The overall pooled proportion of good hand-washing practice at critical times among mothers of children under-five age in Ethiopia was 43.18% (95% CI = 31.05, 55.31). Insufficient water (AOR = 0.33, 95% CI: 0.13, 0.52), good knowledge (AOR = 1.35, 95% CI = 1.09, 1.61), desirable attitude (AOR = 4.34, 95% CI = 1.84, 6.84) and higher educational level (AOR = 0.17, 95% CI = 0.08, 0.25) were significantly associated with good practice of hand-washing at critical times. The national level of good practice of hand-washing at critical times was low. Hence, to promote good practice of hand-washing, it is essential to increase the accessibility of water and provide hygiene health education and training programs to improve knowledge and desirable attitudes of mothers., (© 2024. The Author(s).)

Background: Big health data is a large and complex dataset that the health sector has collected and stored continuously to generate healthcare evidence for intervening the future healthcare uncertainty. However, data use for decision-making practices has been significantly low in developing countries, especially in Ethiopia. Hence, it is critical to ascertain which elements influence the health sector's decision to adopt big health data analytics in health sectors. The aim of this study was to identify the level of readiness for big health data analytics and its associated factors in healthcare sectors., Methods: A cross-sectional study design was conducted among 845 target employees using the structural equation modeling approach by using technological, organizational, and environmental (TOE) frameworks. The target population of the study was health sector managers, directors, team leaders, healthcare planning officers, ICT/IT managers, and health professionals. For data analysis, exploratory factor analysis using SPSS 20.0 and structural equation modeling using AMOS software were used., Result: 58.85 % of the study participants had big health data analytics readiness. Complexity (CX), Top management support (TMS), training (TR) and government law policies and legislation (GLAL) and government IT policies (GITP) had positive direct effect, compatibility (CT), and optimism (OP) had negative direct effect on BD readiness (BDR)., Conclusion: The technological, organizational, and environmental factors significantly contributed to big health data readiness in the healthcare sector. The Complexity, compatibility, optimism, Top management support, training (TR) and government law and IT policies (GITP) had effect on big health data analytics readiness. Formulating efficient reform in healthcare sectors, especially for evidence-based decision-making and jointly working with stakeholders will be more relevant for effective implementation of big health data analytics in healthcare sectors., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Authors.)

Ethiopia's sub-humid highlands face a critical challenge in balancing agricultural productivity with land degradation. This study explores the effectiveness of soil and water conservation practices (SWCPs) in addressing this challenge. We investigated the interaction effects of types of SWCPs, landscape positions, and location on Teff ( Eragrostis teff ) and wheat ( Triticum aestivum ) yield. In addition, we assessed the economic viability of SWCPs using cost-benefit analysis with farmer-funded and cost-sharing scenarios. The results indicated that yield was significantly affected by the interactions between factors like SWCP type and landscape position. Soil bunds consistently increased crop yield across diverse locations and landscapes, indicating superior erosion control benefits. Lower landscape positions on foot slopes benefited most from SWCP implementation. Teff yield increased by 188 % and wheat yield by 181 % under soil bunds. The cost-benefit analysis confirmed the financial viability of SWCPs, particularly for Teff (NPV = 4499.35 USD, IRR = 50 %, and BCR = 1.51) and wheat (NPV = 544.35 USD, IRR = 16 %, and BCR = 1.06) grown on lower landscapes with farmer-funded investment scenarios. Positive return on investment was observed in both scenarios, with cost-sharing offering greater economic benefits for farmers. These findings highlight the importance of an integrated approach to SWC implementation for achieving multiple Sustainable Development Goals (SDGs) by enhancing food security, improving farmer incomes, and promoting sustainable and productive landscape management practices. Future research should explore the long-term sustainability of SWCPs, their adaptation across diverse agroecological zones and landscapes, the incorporation of various crops, the broader socioeconomic impacts, and the development of effective extension programs for wider adoption by farmers., Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Aschalew Kassie Tebeje reports a relationship with Lihiket Design and Supervision Corporation that includes: employment. Aschalew K. Tebeje, and Yonas L. Tsegaw, were employed by Lihiket Design and Supervision Corporation. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Authors.)

Background: Teenage pregnancy remains one of the major reproductive health problems, especially in sub-Saharan African countries. It can lead to maternal and neonatal complications and social consequences. The proportion of teenage pregnancy differs across regions of Ethiopia. Thus, this study aimed to determine the spatial variation in determinants of teenage pregnancy among adolescents aged 15-19 years in Ethiopia using the 2019 Demographic and Health Survey (DHS)., Methods: This study included a total weighted sample of 2165 teenage girls aged 15 to 19 years. A mixed-effect binary logistic regression model was employed to consider the hierarchical nature of the DHS data using STATA version 17. Adjusted odds ratios with 95% confidence intervals are reported, and a p-value less than 0.05 was used to identify significant predictors. The spatial analysis was conducted with ArcGIS version 10.7 and Python 3. To identify factors associated with the hotspots of teenage pregnancy, a multiscale geographically weighted regression (MGWR) was performed. Spatial regression models were compared using adjusted R2, the corrected Akaike information criterion (AICc), and the residual sum of squares (RSS)., Results: The prevalence of teenage pregnancy among adolescents aged 15 to 19 years was 12.98% (95% CI: 11.6%, 14.5%). It was spatially clustered throughout the country with a significant Moran's I value. Significant hotspot areas were detected in central and southern Afar; northern, central, and western Gambela; northeastern and southern central Oromia; and the eastern Somali region. The MGWR analysis revealed that the significant predictors of spatial variations in teenage pregnancy were being illiterate and being married. Based on the multivariable multilevel analysis, age 17 (AOR = 3.54; 95% CI: 1.60, 7.81), 18 (AOR = 8.21; 95% CI: 3.96, 17.0), 19 (AOR = 15.0; 95% CI: 6.84, 32.9), being literate (AOR = 0.57; 95% CI: 0.35, 0.92), being married (AOR = 22.8; 95% CI: 14.1, 37.0), age of household head (AOR = 0.98; 95% CI: 0.98, 0.99) and residing in the Gambela region (AOR = 3.27; 95% CI: 1.21, 8.86) were significantly associated with teenage pregnancy among adolescents aged 15 to 19., Conclusion: Teenage pregnancy is a public health problem in Ethiopia. Policymakers should prioritize addressing early marriage and improving teenage literacy rates, with a focus on the Gambela region and other hotspot areas. It is crucial to implement policies aimed at transforming the traditional practice of early marriage and to take measures to enhance literacy levels and promote awareness about sexual and reproductive health at the family and school levels. This will help ensure that young people have the opportunity to pursue education and make informed decisions about their reproductive health., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2024 Tebeje et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)

Background: The COVID-19 pandemic is one of the most devastating public health emergencies of international concern to have occurred in the past century. To ensure a safe, scalable, and sustainable response, it is imperative to understand the burden of disease, epidemiological trends, and responses to activities that have already been implemented. We aimed to analyze how COVID-19 tests, cases, and deaths varied by time and region in the general population and healthcare workers (HCWs) in Ethiopia., Methods: COVID-19 data were captured between October 01, 2021, and September 30, 2022, in 64 systematically selected health facilities throughout Ethiopia. The number of health facilities included in the study was proportionally allocated to the regional states of Ethiopia. Data were captured by standardized tools and formats. Analysis of COVID-19 testing performed, cases detected, and deaths registered by region and time was carried out., Results: We analyzed 215,024 individuals' data that were captured through COVID-19 surveillance in Ethiopia. Of the 215,024 total tests, 18,964 COVID-19 cases (8.8%, 95% CI: 8.7%- 9.0%) were identified and 534 (2.8%, 95% CI: 2.6%- 3.1%) were deceased. The positivity rate ranged from 1% in the Afar region to 15% in the Sidama region. Eight (1.2%, 95% CI: 0.4%- 2.0%) HCWs died out of 664 infected HCWs, of which 81.5% were from Addis Ababa. Three waves of outbreaks were detected during the analysis period, with the highest positivity rate of 35% during the Omicron period and the highest rate of ICU beds and mechanical ventilators (38%) occupied by COVID-19 patients during the Delta period., Conclusions: The temporal and regional variations in COVID-19 cases and deaths in Ethiopia underscore the need for concerted efforts to address the disparities in the COVID-19 surveillance and response system. These lessons should be critically considered during the integration of the COVID-19 surveillance system into the routine surveillance system., Competing Interests: The authors have declared that no competing interests exist., (Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.)

SARS-CoV-2 co-infection with the influenza virus or human respiratory syncytial virus (RSV) may complicate its progress and clinical outcomes. However, data on the co-detection of SARS-CoV-2 with other respiratory viruses are limited in Ethiopia and other parts of Africa to inform evidence-based response and decision-making. We analyzed 4,989 patients' data captured from the national severe acute respiratory illness (SARI) and influenza-like illness (ILI) sentinel surveillance sites over 18 months period from January 01, 2021, to June 30, 2022. Laboratory specimens were collected from the patients and tested for viral respiratory pathogens by real-time, reverse transcription polymerase chain reaction (RT-PCR) at the national influenza center. The median age of the patients was 14 years (IQR: 1-35 years), with a slight preponderance of them being at the age of 15 to less than 50 years. SARS-CoV-2 was detected among 459 (9.2%, 95% CI: 8.4-10.0) patients, and 64 (1.3%, 95% CI: 1.0-1.6) of SARS-CoV-2 were co-detected either with Influenza virus (54.7%) or RSV (32.8%) and 12.5% were detected with both of the viruses. A substantial proportion (54.7%) of SARS-CoV-2 co-detection with other respiratory viruses was identified among patients in the age group from 15 to less than 50 years. The multivariable analysis found that the odds of SARS-CoV-2 co-detection was higher among individuals with the age category of 20 to 39 years as compared to those less than 20 years old (AOR: 1.98, 95%CI:1.15-3.42) while the odds of SARS-CoV-2 co-detection was lower among cases from other regions of the country as compared to those from Addis Ababa (AOR:0.16 95%CI:0.07-0.34). Although the SARS-CoV-2 co-detection with other respiratory viral pathogens was minimal, the findings of this study underscore that it is critical to continuously monitor the co-infections to reduce transmission and improve patient outcomes, particularly among the youth and patients with ILI., Competing Interests: The authors have declared that no competing interests exist., (Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.)

This study assessed the economic sustainability and contribution of tomato farming ventures to Addis Ababa's resilience. Using a project-based evaluation method, the profitability of tomato production was analyzed with and without the cost of water. The results showed that including the cost of water, the venture had a negative net present value (NPV) of 30100 USD/hectare/annum, an internal rate of return (IRR) of 0.2%, a payback period (PBP) of over ten years, and a cost-benefit ratio (CBR) of 0.83. However, without the cost of water, the venture showed a subtle profit, with an NPV of 15100 USD/hectare/annum, an IRR of 21%, a PBP of 2.9 years, and a CBR of 1.02. Sensitivity analysis revealed that an increase in sales price and yield positively affected profitability, while an increase in operating cost had a negative effect. The study concluded that when water costs are considered, the tomato venture in Addis Ababa is not profitable or sustainable, and does not contribute to the city's resilience. However, without water cost accounting, the venture's contribution to the city's resilience is minimal. The study recommends policy interventions to enhance farmers' access to the market, establish agro-industries, and improve their bargaining power., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Authors. Published by Elsevier Ltd.)

TEAD4 is a transcription factor that plays a crucial role in the Hippo pathway by regulating the expression of genes related to proliferation and apoptosis. It is also involved in the maintenance and differentiation of the trophectoderm during pre- and post-implantation embryonic development. An alternative promoter for the TEAD4 gene was identified through epigenetic profile analysis, and a new transcript from the intronic region of TEAD4 was discovered using the 5'RACE method. The transcript of the novel promoter encodes a TEAD4 isoform (TEAD4-ΔN) that lacks the DNA-binding domain but retains the C-terminal protein-protein interaction domain. Gene expression studies, including end-point PCR and Western blotting, showed that full-length TEAD4 was present in all investigated tissues. However, TEAD4-ΔN was only detectable in certain cell types. The TEAD4-ΔN promoter is conserved throughout evolution and demonstrates transcriptional activity in transient-expression experiments. Our study reveals that TEAD4 interacts with the alternative promoter and increases the expression of the truncated isoform. DNA methylation plays a crucial function in the restricted expression of the TEAD4-ΔN isoform in specific tissues, including the umbilical cord and the placenta. The data presented indicate that the DNA-methylation status of the TEAD4-ΔN promoter plays a critical role in regulating organ size, cancer development, and placenta differentiation.

This study aimed to assess the concentrations of major and trace metals (Na, Ca, Fe, Zn, Ni, Mn, Cu, Cd, and Pb) in date palm fruit samples collected from diverse regions, including Afar (Ethiopia), Iraq, and Saudi Arabia, utilizing flame atomic absorption spectrometry (FAAS). The wet acid digestion method was employed for sample treatment, with optimization of the key parameters such as reagent volume ratio, oven temperature, and digestion time for analytical applications. Under the optimized parameters, average metal concentrations in date palm fruit samples ranged from 205-299, 134-320, 38.8-115, 25.1-42.2, 9.27-27.9, 7.11-16.3, and 0.002-1.15 mg/kg for Ca, Na, Fe, Ni, Zn, Mn, and Cu, respectively. Cd and Pb levels were below detection limits within the linear range. Generally, date palm samples exhibited higher Ca and Na contents and lower concentrations of Cu and Mn than other metals. Pearson correlation analysis revealed very strong positive correlations between Fe and Na, Na and Zn, Na and Mn, Ca and Zn, Fe and Ni, Fe and Mn, and Mn and Ni. Strong negative correlations were observed for Ni and Na, Fe and Cu, and Cu and Ni. Weak correlations were noted among Na and Cu, Ca and Fe, Ca and Ni, Ca and Mn, Ca and Cu, Fe and Zn, Ni and Zn, Zn and Mn, and Zn and Cu. A recovery study using the spiking method demonstrated acceptable percentage recoveries ranging from 91.6% to 97.8%. Health risk assessment, including chronic daily intake (CDI), hazard quotient (HQ), total exposure hazard index (HI), and carcinogenic risk (CR), indicated CDI, HQ, and HI values below 1.0, except for the HI value for Ni. This suggests that the metals pose no probable public health risk, with the absence of Cd and Pb in date palm samples affirming no carcinogenic threats associated with their consumption., Competing Interests: The authors declare that they have no conflicts of interest., (Copyright © 2024 Feven Tamirat et al.)

Objectives: Acute respiratory infections because of respiratory syncytial viruses (RSVs) are among the major leading causes of morbidity and mortality in children worldwide. RSV prevalence and its contributing factors among children aged under 5 years in Ethiopia are not well studied. To assess the prevalence and associated factors of RSV infection in children aged under 5 years using influenza sentinel surveillance sites in Ethiopia., Methods: A cross-sectional study design was used utilizing influenza-like illness/sever acute respiratory illness surveillance data from January 2021 to December 2022 at the Ethiopian Public Health Institute., Results: In total, 2234 cases were included, with an overall RSV positivity rate of 16.2%. The RSV positivity rate was high in children aged under 1 year (22.8%) and during fall season (24.8%). The RSV positivity rate was significantly associated with ages under 1 year (adjusted odds ratio [AOR] 2.8, 95% confidence interval [CI]: 1.89-4.15) and 1-2 years (AOR 1.9, 95% CI: 1.26-2.73) and the fall season (AOR 1.67, 95% CI: 1.17-2.38)., Conclusion: The study revealed that a considerably high RSV positivity rate was detected in children aged under 5 years. The age of children and season have a significant association with RSV positivity rate. Further studies of RSV viral genotype, clinical characteristics, and disease outcome need to be conducted for a better understanding of the virus and disease outcome., Competing Interests: The authors have no competing interests to declare., (© 2024 The Author(s).)

In this study, for the first time, the levels of thirteen micro- and macromineral nutrients in the leaves, seeds, and supportive soil of Moringa stenopetala ( M. stenopetala ) were simultaneously determined using microwave plasma atomic emission spectroscopy (MP-AES). The samples were collected during the arid season, in 2019 from the three main M. stenopetala growing areas in southern Ethiopia (Chano Mile Kebele, Nechisar Kebele, and Konso Special Woreda). A novel digestion method for leaf and seed samples was developed using an optimized acid mixture (2.5 : 0.75 : 0.5 of HNO 3 , HClO 4 , and H 2 O 2 ) at 240°C for 2 hrs and 30 min, resulting in clear and colorless solutions. The method makes the digestion process more efficient by minimizing the reagent volume, reducing digestion temperature and time, and simplifying the overall procedure. The efficiency of the optimized procedure was validated by spiking experiments, and the percentage recovery ranged between 94 and 110%. Under optimized experimental conditions, higher concentrations of essential minerals (K, Na, Ca, and Mg) were observed in the plant leaf and seed samples from the three areas. In addition, significant amounts of trace elements (Fe, Mn, Zn, and Cu) were also found. Importantly, no traces of the toxic elements (Cd and Pb) were detected in any of the analyzed samples, suggesting that the leaves and seeds of M. stenopetala are valuable sources of both micro- and macromineral nutrients and are safe from toxic metals. From a dietary perspective, the seed contains almost comparable concentrations of minerals as the leaves. As a result, the seeds of M. stenopetala can serve as an alternative source of minerals and play a role in overcoming the current global food crisis, particularly in the dry season. Analysis of variance at a 95% confidence level revealed significant differences in the levels of all mineral nutrients between the three sample means except K, Ca, Co, and Cu. Generally, the developed method includes an innovative digestion procedure that minimizes reagent consumption, operates at lower temperatures, and requires shorter digestion times, thereby optimizing resource utilization and maintaining analytical accuracy. Notably, the absence of toxic elements in the MP-AES procedure highlights the safety and reliability of M. stenopetala leaves and seeds as valuable, contamination-free sources of essential nutrients., Competing Interests: The authors declare that they have no conflicts of interest or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Ashenafi Shemnsa et al.)

Background: Short-term anthropometric outcomes are well documented for children treated for severe acute malnutrition (SAM). However, anthropometric recovery may not indicate restoration of healthy body composition., Objectives: This study aimed to evaluate long-term associations of SAM with growth and body composition of children 5 y after discharge from community-based management of acute malnutrition (CMAM)., Methods: We conducted a 5-y prospective cohort study, enrolling children aged 6 to 59 mo discharged from CMAM (post-SAM) (n = 203) and nonmalnourished matched controls (n = 202) from Jimma Zone, Ethiopia in 2013. Anthropometry and body composition (bioelectrical impedance) were assessed. Multiple linear regression models tested differences in height-for-age (HAZ), weight-for-age (WAZ), and body mass index-for-age (BAZ) z-scores; height-adjusted fat-free mass index (FFMI); and FM index (FMI) between groups., Results: Post-SAM children had higher stunting prevalence than controls at discharge (82.2% compared with 36.0%; P < 0.001), 1 y (80.2% compared with 53.7%; P < 0.001), and 5 y postdischarge (74.2% compared with 40.8%; P < 0.001). Post-SAM children remained 5 cm shorter throughout follow-up, indicating no HAZ catch-up. No catch-up in WAZ or BAZ was observed. Post-SAM children had lower hip (-2.05 cm; 95% CI: -2.73, -1.36), waist (-0.92 cm; CI: -1.59, -0.23) and mid-upper arm (-0.64 cm; CI: -0.90, -0.42) circumferences and lower-limb length (-1.57 cm; 95% CI: -2.21, -0.94) at 5 y postdischarge. They had larger waist-hip (0.02 cm; 95% CI: 0.008, 0.033) and waist-height (0.013 cm; 95% CI: 0.004, 0.021) ratios, and persistent deficits in FFMI at discharge and 6 mo and 5 y postdischarge (P < 0.001 for all). No difference was detected in head circumference, sitting height, or FMI., Conclusions: Five y after SAM treatment, children maintained deficits in HAZ, WAZ, BAZ, and FFMI, with preservation of FMI, sitting height, and head circumference at the expense of lower-limb length, indicating a "thrifty growth" pattern. Research is urgently needed to identify effective clinical and public health interventions to mitigate these consequences of malnutrition., (Copyright © 2023 American Society for Nutrition. All rights reserved.)

Background: High penetration of smartphones and ownership among the young generation increased the utilization of mobile health applications for health management among university students more than ever. Compared to other health service provision mechanisms mobile health service has higher advantages in promoting a healthy lifestyle since it is not limited to time and space. Even though there are numerous studies conducted in the area of mobile health utilization, this phenomenon is not well studied among university students in Ethiopia, Hence this study aims to determine the level of mobile health applications utilization among health science students., Method: A cross-sectional study was carried out at Debre Markos University from April 05 to June 25, 2022 among health science students. For this study, 423 students were recruited from health Science College using a systematic sampling method. The data was gathered using a self-administered questionnaire. Using SPSS version 26 software descriptive analysis, bivariate and multivariable logistic regressions were performed. A P-value of .05 at a 95% confidence interval was considered statistically significant. The questionnaire's validity was determined by expert opinion, and by calculating its reliability using cronbach alpha (α = .78)., Result: This study revealed that more than half 59% (144/244) of the study participants have installed and utilized 1-3 health-related apps. Among the students who have mobile health applications 38.6% utilize mobile health application several times a day while only 2.1% utilized rarely. Usage history shows that 40% of the study participants utilized the applications for a year, while 15.4% of the students utilized them for more than 2 years. Easiness of applications (AOR = 4.8, 95%CI: [2.1-11.2]), skill AOR = 4.2, 95%CI: [3.8-12]) and trust (AOR = 2.8, 95%CI: [1.6-4.8]) were among the factors that were associated with mobile health applications utilization. Students were asked about the barriers that limit the use mobile health applications and self-reported barriers includes Lack of knowledge and awareness of application benefits, and Lack of adequate time to use applications., Conclusion: The study shows that mobile health applications utilization is moderate relative to previous studies. Mobile health application developers for the young generation should consider healthy lifestyle related applications like fitness and weight loss apps., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2023 Hailiye Teferi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)

Nutrient management research was conducted across locations to investigate the influence of landscape position (hill, mid-, and foot slope) in teff ( Eragrostis tef ) and wheat ( Triticum aestivum ) yield response to fertilizer application and liming in the 2018 and 2019 cropping seasons. The treatments included 1) NPS fertilizer as a control treatment (42 N + 10P + 4.2S kg ha -1 for teff and 65 N + 20P + 8.5S kg ha -1 for wheat); 2) NPS and potassium (73 N + 17P + 7.2S + 24 K kg ha -1 for teff and 103 N + 30P + 12.7S + 24 K kg ha -1 for wheat) and 3) NPSK and zinc (73 N + 17P + 7.2S + 24K + 5.3Zn kg ha -1 for teff and 103 N + 30P + 12.7S + 24K + 5,3Zn kg ha -1 for wheat) in acid soils with and without liming. Results showed that the highest teff and wheat grain yields of 1512 and 4252 kg ha -1 were obtained at the foot slope position, with the respective yield increments of 71% and 57% over the hillslope position. Yield response to fertilizer application significantly decreased with increasing slope owing to the decrease in soil organic carbon and soil water content and the increase in soil acidity. The application of lime with NPSK and NPSKZn fertilizer increased teff and wheat yields by 43-54% and 32-35%, respectively compared to the application of NPS fertilizer without liming where yield increments were associated with the application of N and P nutrients. Orthogonal contrasts revealed that landscape position, fertilizer application, and their interaction effects were significant on teff and wheat yields. Soil properties including soil pH, organic carbon, total N, and soil water content were increased down the slope, which might be attributed to sedimentation down the slope. However, available P is yet very low both in acidic and non-acidic soils. We conclude that crop response to applied nutrients could be enhanced by targeting nutrient management practices to agricultural landscape features and addressing other yield-limiting factors such as soil acidity and nutrient availability by conducting further research., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper, (© 2023 The Authors.)

Land degradation is one of the contemporary environmental challenges affecting regions inhabited by over one-third of the global population. In response to land degradation, restoration of degraded landscapes through area closure has been implemented through government and bilateral organizations for the last three decades in Ethiopia. Objectives of this study were to: i) explore the effects of landscape restoration on vegetation cover; ii) identify the perceived benefits to local communities; and 3) synthesize the lessons learnt on communities' willingness to sustain the restored landscapes. The study was conducted in project-supported restoration areas including the Dimitu and Kelisa watersheds representing the central rift valley dry lands and the Gola Gagura watershed representing the eastern dry land areas around Dire Dawa. The temporal changes in land use and land cover due to area closure integrated with physical and biological soil and water conservation measures were detected using GIS/Remote sensing techniques. Moreover, eighty-eight rural households were interviewed. The results of the study revealed that landscape restoration activities such as area closure integrated with physical soil and water conservation, and planting of trees and shrubs contributed to the significant changes in land covers of the watersheds in 3-5 years. Hence, barren lands were reduced by 35-100% while there were significant increases in forest lands (15%), woody grasslands (247-785%), and bushlands (78-140%). More than 90% of the respondents in the Dimitu and Gola Gagura watersheds verified that the landscape restoration activities improved vegetation cover and ecosystem services, reduced erosion, and increased incomes. A great majority of farm households (63-100%) expressed their willingness to contribute to different forms of landscape restoration interventions. Encroachment of livestock to closed area, shortage of finance, and the growing number of wild animals in closed area were the perceived challenges. Proper planning and implementation of integrated interventions, creating local watershed user associations, ensuring appropriate benefit-sharing and implementing innovative pathways to reconcile the tradeoffs could be considered to scale up interventions and address potential conflicts of interest., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Ltd. All rights reserved.)

Early discontinuation of breastfeeding is known to be associated with avoidable childhood morbidity and mortality. The effect of maternal employment on the duration of exclusive breastfeeding and its determinants has not been addressed adequately in in Ethiopia in general and in the stud area in particular. Hence, this study was aimed to compare the time to stop exclusive breastfeeding and its determinants among employed and unemployed mothers of infants 6-12 months of age. A community-based comparative cross-sectional study was conducted from March 1 to 30, 2019. A total of 426 mothers were recruited using a simple random sampling technique. The Kaplan-Meier curve with log-rank test was used to compare the difference in cessation of exclusive breastfeeding before 6 months. Bivariate and Cox proportional hazards model were computed. Hazard ratios and their 95% confidence intervals were computed to determine the level of significance. Four hundred twenty-six (213 employed and 213 un-employed) mothers were included in the final analysis. The median duration of exclusive breastfeeding was 4 months and 6 months for infants of employed and unemployed mothers, respectively. The likelihood of ceasing of exclusive breastfeeding before 6 months of age was significantly associated with family support of exclusive breastfeeding [AHR = 3.99, 95% CI (1.9, 8.3)], and lack of exclusive breastfeeding counseling during postnatal care [AHR = 7.76, 95% CI (2.99, 20.1)], primipara mothers [AHR = 1.5, 95% CI (1.14, 2.04)], maternity leave of 4 months [AHR = 7, 95% CI 2.2, 22.2)] and employed mothers [AHR = 3.77, 95% CI (2.4, 5.9)]. The median duration of exclusive breastfeeding was shorter among employed mothers than un-employed mothers. It is clear from this study that cessation of exclusive breastfeeding was associated with the duration of paid maternity leave for employed mothers. Family support and perceived adequacy of breast milk were associated with cessation of exclusive breastfeeding before 6 months among unemployed mothers., (© 2023. The Author(s).)

Community-based organizations (CBOs) and individuals primarily engaged in forest management dedicated to carbon credit run both at national and regional levels. After a span of time elapsed in the same, CBOs and individuals aspired to shift the carbon-dedicated forest either into log or timber production based on an informed decision. However, there is no study done so which of these projects is financially more useful to them to make an informed decision. The objective of the study is, therefore, to make comparative analyses of plantation forests for carbon credit, round log and timber. The result has revealed that plantation forest managed for timber production is most attractive and rewarding in year 10 and year 15 both with and without discounting at 3%. Plantation forest managed for timber production enables the creation of a fixed asset than both carbon credit and log production. Plantation forests managed for the carbon credit, log production and timber production have externalities both positive and negative which must be considered while calculating the costs and benefits accrued thereof. There are existing and emerging risks associated with the carbon credit project which shifts from natural (forest) to technological abatement of climate change. The study is critical to understanding the benefits of future plantation forest investment. We, thus, conclude forest managed for timber production is financially more useful for CBOs and individuals than round log and carbon credit. We recommend CBOs and individuals to have adequate information on benefits and risks associated with plantation forests managed for carbon credit, round log and timber production before engaging in the investment., Competing Interests: The authors declare no conflict of interest., (© 2023 The Authors.)

Introduction: Tuberculosis (TB) was one of the top causes of ill health and the leading cause of deaths worldwide until the coronavirus (COVID-19) pandemic. Hence, this study is aimed at assessing the prevalence of sputum smear-positive TB and associated factors among TB-suspected patients attending in Gedeo Zone health facilities, Southern Ethiopia., Methods: A facility-based cross-sectional study was conducted among 220 TB-suspected patients in Gedeo Zone health facilities from July 01 to Sep 30, 2021. Patients were grouped as smear positive if one sputum out of two was positive or two sputum smears became positive. Various descriptive statistics were computed using the SPSS-25, and factors to smear positivity were identified by multivariable logistic regression analysis. Odds ratio at 95% CI and p values < 0.05 were considered as indicators of statistical association., Results: The overall prevalence of smear-positive TB in Gedeo Zone health facilities was 18.2%, which is significantly high, and the MTB detection rate of GeneXpert was 29.5%. Contact with a TB patient, cigarette smoking, and previously treatment for TB were factors significantly associated with smear-positive TB., Conclusion: The prevalence rate of smear-positive PTB in the study area was 18.2% and 29.5% by direct sputum AFB and sputum GeneXpert, respectively. As a result, we recommend intervention on the identified associated risk factors and further studies to ascertain risk factors and their magnitude at the community level., Competing Interests: The authors declare that they have no competing interests., (Copyright © 2023 Bahru Mantefardo et al.)

Background: The prevalence and determinants of antenatal care (ANC) dropout in Ethiopia were studied. However, the results were inconsistent and showed considerable variation. Hence, this meta-analysis aimed at estimating the overall prevalence of ANC dropout and its predictors in Ethiopia., Methods: A comprehensive search of published studies was done using different international databases such as such as PubMed, DOJA, Embase, Cochrane Library, Google Scholar, and the institutional repository of Ethiopian universities were used to search for relevant studies. Data were extracted using Microsoft Excel spreadsheet, and exported to STATA v17 for analysis. A random effect model was used to estimate the overall national prevalence of ANC dropout. Fixed effects model were used to compute the pooled adjusted odd ratios (AOR) with the corresponding 95% confidence intervals (CIs). I 2  test was used to assess heterogeneity of the included studies. Egger's tests was used to check for the presence of publication bias., Results: A total of 7 studies were included in this systematic review and meta-analysis with 11,839 study participants. The overall pooled prevalence of ANC in Ethiopia was found to be 41.37% (95% CI =35.04, 47.70). Distance from the health care facility (AOR = 2.93, 95% CI = 2.75, 3.11), pregnancy complication signs (AOR = 2.97, 95% CI = 2.77, 3.16), place of residence (AOR =  1.79, 95% CI = 1.31, 2.26), educational level (AOR = 1.79, 95%CI = 1.37, 2.21), and age group (30-49) (AOR = 0.61, 95% CI = 0.45, 0.78) were significantly associated with ANC dropout., Conclusion: Based on this review and meta-analysis, 41% of Ethiopian women dropped out of ANC visits before the minimum recommended visit (4 times). Hence, to reduce the number of ANC dropouts, it is important to counsel and educate women during their first prenatal care. Issues of urban-rural disparities and noted hotspot areas for ANC dropout should be given further attention., Competing Interests: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article., (© The Author(s) 2023.)

This paper demonstrates a highly sensitive Voltammetric sensor for determination of brucine (BRU) in artificial urine sample based on choline chloride modified glassy carbon electrode (ChCl/GCE). The simple and cost effective modification was performed by electrodeposition of choline chloride on glassy carbon electrode surface using cyclic voltammetry technique. The modified electrode surface was characterized by electrochemical, spectroscopic and microscopic imaging. The electrode yields a well-resolved peak current for the irreversible oxidation of brucine in the first scan and a pair of quasi-reversible peaks during the second scan. The CV study indicates that brucine undergoes an adsorption controlled electrochemical process with equal number of electrons and protons transfer on the ChCl/GCE. The SWV result shows that the reduction peak current of BRU at the ChCl/GCE was linear in the range of 0.001 μM-10 μM with limit of detection 8 × 10 -5  μM, limit of quantification 2.6 × 10 -4  μM and sensitivity of 116.4 μA/μM. The ChCl/GCE also showed an excellent selectivity, reproducibility and long-time stability towards the electrochemical reduction of Brucine. Moreover, the practical applicability of the fabricated ChCl/GCE was examined in order to determine BRU in artificial urine samples with recovery ranging from 95.5 to 102.7%. The validity of the developed method was confirmed by chromatographic techniques, high-performance liquid chromatography (HPLC) and the results obtained are consistent the HPLC method., (© 2023 The Authors.)

Background: Due to the scarcity of intervention trials, especially in Ethiopia, the effect of nutrition education and counseling intervention on pregnancy outcomes is not well studied. Aim: To assess the effect of nutrition education and counseling on the outcomes of pregnancy among pregnant mothers in public health care institutions of Gedeo Zone, Southern, Ethiopia. Methods: A cluster randomized control trial study design was undertaken. Simple random sampling followed by cluster sampling was used to reach eligible study participants. A total sample of 235 (115 intervention vs.120 control group) pregnant women who followed anti-natal care service in public health facilities of Gedeo Zone was included in the study. Independent t -test was used to analyze the group difference for continuous variable and chi-square test for categorical variables. The post-intervention values between the two groups were compared using analysis of covariance by adjusting to baseline variable. Results: After nutrition education, pregnant women in the control group had less weight gain than in the intervention. The proportion of LBW neonate was 17.8% in the intervention group and 38.2% in the control group ( P  < 0.001). Multivariable logistic regression analysis showed that the risk of LBW in the control group was 2.43 more likely than in the intervention group (AOR = 2.43; 95% CI: (1.2, 4.92)). Conclusion: Nutrition education delivered to pregnant women during pregnancy could reduce maternal malnutrition and low birth weight. Recommendation: The intervention is easy to implement in the health facilities of Gedeo zone and would be implemented without delay to achieve the sustainable development goals.

Objectives: This study aimed to assess the prevalence of, and factors associated with, early initiation of antenatal care (ANC) follow-up among pregnant women attending ANC services at Bahir Dar Zuria zone public health centres (HCs), Bahir Dar, Northwest Ethiopia., Design: An institution-based, cross-sectional study was conducted from 15 December 2020 to 1 March 2021. A systematic random sampling technique was applied to select the study participants., Setting: Five public HCs (Han HC, Shimbit HC, Dagmawi Minilik HC, Shumabo HC and Meshentie HC) in Bahir Dar Zuria zone., Participants: Pregnant mothers who were attending their ANC service during the data collection period were enrolled in this study. A total of 592 mothers were interviewed for the study., Outcome Measure: Early initiation of ANC services (within 16 weeks of gestation)., Results: 48.6% (95% CI 41.6% to 53.5%) of participants began their first ANC service before 16 weeks of gestation. Family size less than five (adjusted OR 2.0, 95% CI 1.25 to 3.25), urban residence (3.0, 1.48 to 6.17), secondary education (2.1, 1.3 to 3.6), college-level education and above (3.5, 1.8 to 6.8), primigravida (2.6, 1.65 to 4.14), planned pregnancy (3.5, 1.5 to 8.1) and knowledge about early initiation of ANC (1.7, 1.14 to 2.55) were significantly associated with early initiation of ANC., Conclusion: A substantial number of participants had not received ANC services in a timely manner. Sociodemographic and obstetric characteristics of the respondents were associated with timely booking of ANC services. Dissemination of information about recommended time to initiate ANC services and efforts to improve women's educational status to increase knowledge about early initiation of ANC are needed in the region., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)

Environmental impact statement (EIS) is rarely assessed for its quality and thus, poses challenges for rectifying the compromised qualities at earlier time. The objective of the study was to evaluate the quality of the Environmental Impact Statement (EIS) submitted to Addis Ababa Environmental Protection and Green Development Commission (AAEPGDC) in year 2020 and 2021. The article has evaluated the quality of 16 EIS for the year 2020 and 15 for the year 2021 using the modified Lee and Colley review package. The findings revealed that each of the evaluation criteria has shown various degrees of qualities with overall assessment that falls under satisfactory score of 66% (sum of grade A-C). Impact identification & description, monitoring plan and project setting and description were the most described sections of the EIS while baseline assessment and establishment, scoping, alternate consideration were otherwise. Inadequate baseline description was found resulting in compromising impact prediction. Though adverse impact identification and description was the best dealt with section of the EIS, it overlooked describing how impacts affect receptors, undermined occupation health & safety and disregarded project affected people by luring them with job opportunity. In terms of magnitude, positive impacts were presented pretty well than adverse impacts. How long the duration of the impacts last were not dealt by 39%, as to whether the impact were reversible or not were not dealt by 42% and the extent of coverage of the impacts were not discussed by 39% of the reviewed EIS. Energy use was one of the least described EIS section (64.5% score) with gaps of failing to recommend renewable energy for best energy use practices. Comparisons of the EIS quality for 2020 and 2021 using Mann-Whitney U-test had shown that there was no quality difference between them. We thus, generally recommend multi-stage review processes at least every five years to enhance the overall quality of the EIS., Competing Interests: The authors declare no competing interests., (© 2022 Published by Elsevier Ltd.)

Background: Husbands' involvement strategies are employed to support their wives to access care, address the influence of gender inequality on maternal and newborn health, and promote husbands' positive involvement as fathers. Yet, evidence of the husbands' involvement in skilled birth attendant service utilization in Ethiopia is scarce, which limits the facility to improve institutional delivery services. Therefore, this study aimed to assess the magnitude of husbands' involvement in skilled birth attendant service utilization among fathers of children of less than one year in Deder town, Oromiya, Ethiopia., Methods: A community-based cross-sectional study was conducted using a structured questionnaire among 399 fathers selected by a simple random sampling technique. Data were collected through face-to-face interview from March 24 to April 20, 2021. Data entry was done by Epi-data version-4.2 and analyzed with SPSS version-21. Descriptive statistics used frequency, mean and median and presented by tables and figures. The level of significance was set at p-value ≤0.05 for multivariable logistic regression and an adjusted odds ratio with a 95% confidence interval was used to measure the degree of statistical significance of dependent and independent variables., Result: The prevalence of husbands' involvement in skilled birth attendant service utilization was 84.2%. The age group of 25 to 29 years (AOR = 2.63, CI: 1.124-6.142), prior knowledge of skilled-delivery attendants (AOR = 2.75, CI: 1.456-5.205) and good attitude towards skilled birth attendants (AOR =2.46, CI: 1.227-4.948) were statistically significant determinants of husbands' involvement in skilled birth attendants service utilization., Conclusion and Recommendation: This study revealed that the husbands' involvement in skilled birth attendants was high. Age, level of knowledge and attitude were the significant determinants of husbands' involvement in promoting skilled-delivery attendants. Therefore, improving husbands' level of knowledge and attitude towards skilled birth attendants is needed., (© 2022. The Author(s).)

Background: Corona Virus Disease 2019 is a novel respiratory disease commonly transmitted through respiratory droplets. The disease has currently expanded all over the world with differing epidemiologic trajectories. This investigation was conducted to determine the basic clinical and epidemiological characteristics of the disease in Ethiopia., Methods: A prospective case-ascertained study of laboratory-confirmed COVID-19 cases and their close contacts were conducted. The study included 100 COVID-19 laboratory-confirmed cases reported from May 15, 2020 to June 15, 2020 and 300 close contacts. Epidemiological and clinical information were collected using the WHO standard data collection tool developed first-few cases and contacts investigation. Nasopharyngeal and Oropharyngeal samples were collected by using polystyrene tipped swab and transported to the laboratory by viral transport media maintaining an optimal temperature. Clinical and epidemiological parameters were calculated in terms of ratios, proportions, and rates with 95% CI., Result: A total of 400 participants were investigated, 100 confirmed COVID-19 cases and 300 close contacts of the cases. The symptomatic proportion of cases was 23% (23) (95% CI: 15.2%-32.5%), the proportion of cases required hospitalization were 8% (8) (95%CI: 3.5%-15.2%) and 2% (95%CI: 0.24% - 7.04%) required mechanical ventilation. The secondary infection rate, secondary clinical attack rate, median incubation period and median serial interval were 42% (126) (95% CI: 36.4%-47.8%), 11.7% (35) (95% CI: 8.3%-15.9%), 7 days (IQR: 4-13.8) and 11 days (IQR: 8-11.8) respectively. The basic reproduction number (RO) was 1.26 (95% CI: 1.0-1.5)., Conclusion: The proportion of asymptomatic infection, as well as secondary infection rate among close contacts, are higher compared to other studies. The long serial interval and low basic reproduction number might contribute to the observed slow progression of the pandemic, which gives a wide window of opportunities and time to control the spread. Testing, prevention, and control measures should be intensified., Competing Interests: All authors declared that they have no competing interests.

Background: The deficiency of vitamin B2 can lead to many health problems. Therefore, it is necessary to develop a sensitive, selective and fast method for the determination of vitamin B2 in food samples. In this work, a sensitive, selective and low-cost electrochemical sensor was developed using poly (glutamic acid) and Zinc oxide nanoparticles (ZnO NPs) for vitamin B2 in non-alcoholic beverage and milk samples., Methods: The modification of the electrode surface was carried out by electropolymerization of glutamic acid on ZnO NPs-carbon paste electrode (ZnO NPS-CPE). The prepared electrodes were characterized by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), scanning electron microscopy (SEM) and X-Ray diffraction (XRD). CV and square wave voltammetry (SWV) were used to investigate the electrochemical behavior of vitamin B2 at the modified electrode. The effect of various parameters such as amount of ZnO NPs, polymerization cycle, concentration of the monomer, pH, scan rate and accumulation time were optimized to obtain maximum sensitivity at the modified electrode., Results: The developed sensor showed high electrocatalytic activity towards vitamin B2. Under the optimized conditions, the developed sensor showed a linear response in the range 0.005-10 µM with a low detection limit of (LOD) 0.0007 ± 0.00001 µM and high sensitivity of 21.53 µA/µM., Conclusions: A reproducible, repeatable, stable and selective sensor was successfully applied for the quantification of vitamin B2 in beverage and milk samples with acceptable recoveries in the range of 88-101%., (© 2022. The Author(s).)

Objective: This study aimed to assess the time to severe coronavirus disease 2019 (COVID-19) and risk factors among confirmed COVID-19 cases in Southern Ethiopia., Method: This two-center retrospective cohort study involved patients with confirmed COVID-19 from 1 October 2020 to 30 September 2021. Kaplan-Meier graphs and log-rank tests were used to determine the pattern of COVID-19 severity among categories of variables. Bivariable and multivariable Cox proportional regression models were used to identify the risk factors of severe COVID-19., Results: Four hundred thirteen patients with COVID-19 with a mean age of 41.9 ± 15.3 years were involved in the study. There were 194 severe cases (46.9.1%), including 77 (39.6%) deaths. The median time from symptom onset to severe COVID-19 was 8 days (interquartile range: 7-12 days). The risk factors for severe COVID-19 were age >65 (adjusted hazard ratio [AHR] = 2.65, 95% confidence interval [95%CI]: 1.02, 3.72), cough (AHR = 1.59, 95%CI: 1.39, 2.84), chest pain (AHR = 1.47, 95%CI: 1.34, 2.66), headache (AHR = 2.04, 95%CI: 1.43, 2.88), comorbidity (AHR = 1.3, 95%CI: 1.01, 2.04), asthma (AHR = 1.6. 95%CI: 1.04, 2.24), and symptom onset to admission more than 5 days (AHR = 0.48, 95%CI: 0.34, 0.68)., Conclusion: Patients with symptoms and comorbidities should be closely monitored.

Background: Balanced and adequate nutritious food during pregnancy helps to improve maternal weight and for the healthy growth of the fetus. There has been little progress in reducing pregnant undernutrition in Ethiopia; it has been too slow., Objective: The objective of this study was to assess the prevalence of undernutrition and associated factors among pregnant women in public health care hospitals of Gedeo Zone, Southern Ethiopia., Method: A cross-sectional study design was used in public hospitals of Gedeo Zone, Southern Ethiopia from February 01 to March 01, 2019. Pretested structure questionnaire was used to collect data on the socio-economic and demographic characteristics of the study participants. Epi-data was used to code and enter the data and SPSS-25 was used to analyse and interpret the data. To assess the relationship between the dependent and the independent variables, bi-variable and multivariable logistic regression analysis was done., Results: In this study, the prevalence of undernutrition among pregnant women was 21% (95% CI: 20.8-21.2). After controlling other co-variables, the multivariable logistic regression model revealed that average monthly income, women's educational status, nutrition education and counseling, and parity were found to have a significant association with pregnant women's nutritional status. The odds of under-nutrition among pregnant women whose monthly income is <800 ETB were 2.8 times higher than those whose monthly incomes were >1500 (AOR: 2.89; 95%CI: 1.49-5.6)., Conclusion: In this study the magnitude of undernutrition among pregnant women was found to be higher than the previously reported findings. Average household monthly income, family size, mother's educational status, nutrition education and counseling, current health condition of the mother, and parity were factors significantly associated with undernutrition of pregnant mothers. Therefore, Interventions should be initiated in earlier stages of pregnancy to prevent the high level of undernutrition during the second and third trimester in this study area., Competing Interests: The authors declare no conflict of interest., (© 2022 The Author(s).)

Background: Outpatient therapeutic program (OTP) brings the services for the management of Severe Acute Malnutrition (SAM) closer to the community by making services available at decentralized treatment points within the primary health care setting. Despite the available interventions to tackle nutritional problems, there is scarce information on time to recovery and its predictors. Therefore, the aim of this study was to estimate time to recovery and identify its predictors among children aged 6-59 month with SAM admitted to OTP in Bench Sheko zone Southwest Ethiopia., Methods: A retrospective cohort study was conducted on 588 children who had been managed for SAM under OTP, from September 01, 2018, to August 30, 2019, in 4 public health centers in Bench Sheko zone. A total of 1301 children's card were eligible from them 588 children's cards were selected by simple random sampling methods. Data was entered into EPI- data version 4.4.2 and exported to SPSS version 20 for analysis. Kaplan Meir estimate median time to recovery and survival curve was used to compare the time to recovery using a log-rank test among different characteristics. Cox Proportional Hazard Model was used to identify significant predictors of time to recovery. Association was summarized by using adjusted hazard ratio (AHR) and statistical significance was declared at 95% CI, and P-value < 0.05., Result: Recovery rate was 54.4% with the median recovery time 49 days with an Interquartile range of 21 days. The independent predictors of nutritional recovery time were: newly admitted (AHR = 1.52, 95% CI: 1.17, 2.98),had no diarrhea (AHR = 1.9, 95% CI: 1.52, 2.42), had no cough (AHR = 1.4, 95% CI: 1.13, 1.74) had no blood stool (AHR = 1.55, 95% CI: 1.14, 2.10) had no malaria (AHR = 1.75, 95% CI: 1.32, 2.32), and took deworming (AHR = 1.4, 95% CI: 1.01-1.61)., Conclusion and Recommendation: In the current study recovery rate and the median time of recovery is by far below the standard. Cough, diarrhea, malaria, deworming and admission status were independently associated with recovery time. Health professionals should give attention for early detection and management of co-morbidities. Minster of health should give refreshment community based management of acute malnutrition training for health workers to follow the national guideline strictly., (© 2022. The Author(s).)

Introduction: The healthcare industry is increasingly concerned about medical errors, which are the leading cause of death worldwide and also compromise patient safety. This medical error is even more serious in developing countries where healthcare is not supported by technology. Because of the traditional paper-based prescription system, Ethiopia has an overall medication prescribing error rate of 58.07% that could be avoided if an electronic prescription system was in place. Therefore, this study aims to assess physicians' perceptions towards electronic prescription implementation., Methods: From February 1 to April 5, 2021, an institution-based cross-sectional study was conducted among physicians working in public hospitals in the Amhara region. 384 physicians were selected using a simple random sampling method. The data was collected using a self-administered questionnaire and analysed using SPSS, version 21. To assess factors associated with perception among physicians, a binary and multivariable logistic regression analysis were performed. A P.05 value, at a 95% confidence interval, was considered statistically significant. The validity of the questionnaire was determined based on expert opinion, as well as its reliability was determined by calculating the value of Cronbach alpha (α = .78)., Results: In this study, 231 (76.5%) of study participants had a positive perception of electronic prescription. Around 70.8% had more than 5 years of computer usage experience. Nearly 90% of participants claimed that their prescriptions were legible; however, 89% believe that paper-based prescriptions are prone to error. According to multivariable logistic regression analysis, technical skill [AOR] 4.7, 95% confidence interval [CI] (1.27-17.41), good internet access (AOR 2.82, % CI 1.75-4.54), and perceived usefulness of e-prescription system (AOR 3.31, 95% CI 1.01-12.12) were significantly associated with perception., Conclusions: The majority of respondents have a positive perception of electronic prescription. The most notable factors associated with physician perception were organizational factors, internet access, perceived usefulness of the system, and technical skill., Competing Interests: The authors have declared that no competing interests exist.

Background: Occupational injury is any personal injury, disease or death resulting from an occupational accident sustained on worker in connection with the performance of his or her work. Studies conducted in Ethiopia indicated variable findings ranging from 30% to 84.7% prevalence of occupational injury among construction workers. Therefore, the main aim of this systematic and meta-analysis was to pool the estimates and find the reasons for variability of the findings., Methods: The review has been registered at PROSPERO with registration identification number CRD42020222785 . PubMed, Advanced Google search and Google Scholar databases were searched up to June 20, 2020 to identify relevant articles. Stata v14 (StataCorp, College Station, Texas, USA) was used for meta-analysis. Publication bias was assessed by the funnel plot and more objectively by Egger's regression test. I-squared statistics was used to check the heterogeneity of the studies., Result: This research searched a total of, 1241articles, from these articles 1189 from PubMed, 21 from advanced Google search and 31 from Google scholar databases. A total of 12 studies were included in the analysis and all of them were institutional based cross-sectional studies. All studies were conducted from 2004 to 2018 but published from 2007 to 2019. The prevalence of occupational injury among included studies ranges from 30% to 84.7% while the pooled prevalence of occupational injury among construction workers was 45.64% with 95%CI (33.54-57.74). The effect of each variables against occupational injury was pooled and PPE use [AOR = 1.75, 95%CI (1.46, 2.1)], occupational safety training [AOR = 1.63, 95%CI (1.13, 2.34)] and existence of regular supervision [AOR = 1.4, 95%CI (1.16, 1.68)] were significantly associated to occupational injury among construction workers at p-value ≤ 0.05 with 95% CI., Conclusion: The prevalence of occupational injury among construction workers is still very high and variables such as PPE use, occupational safety training and existence of regular supervision were factors affecting occupational injury among construction workers. Supply and use of PPE, provision of occupational safety training and regular supervision of workers has to be in place in order to reduce or remove occupational injury among construction workers in Ethiopia.

Background: Ethiopia reported the first case of COVID-19 on 13 th March, 2020 with community transmission ensuing by mid-May. A national, population-based serosurvey against anti-SARS-CoV-2 IgG was conducted to measure the prevalence of prior COVID-19 infections and better approximate the burden across major towns in Ethiopia., Methods: We conducted a cross-sectional, population-based serosurvey from June 24 to July 8, 2020 in 14 major urban areas. Two-stage cluster sampling was used to randomly select enumeration areas and households. All persons aged ≥15 years were enrolled. Serum samples were tested by Abbott™ ARCHITECT™ assay for SARS-CoV-2 IgG antibodies. National COVID-19 surveillance data on the median date of the serosurvey is analyzed for comparison., Findings: Adjusted seroprevalence was 3.5% (95% CI: 3.2%-3.8%) after controlling for age, sex and test kit performance. Males (3.7%) and females (3.3%) were nearly equally infected, while middle-aged adults '40-65 years' had the highest (4.0%) prevalence. Gambella (7.5%), Dire Dawa (6.2%) and Jigjiga (6.1%) were the most affected towns. About 6.7% and 8.0% of seropositives had symptoms and chronic underlying illness, respectively. A surveillance system had identified 4,416 RT-PCR confirmed cases in Addis Ababa., Interpretation: This serosurvey shows that a majority of urban Ethiopians remain uninfected with SARS-CoV-2. Most anti-SARS-CoV-2 IgG positive cases were asymptomatic with no underlying illness, keeping case detection to a minimum., (Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.)

Background: Coronaviruses are known as a large family of viruses known to cause respiratory infections which are considered as a pandemic by WHO and widely distributed all over the globe; causing several damages to all aspects of human being's life., Objective: To assess and identify the determinants of government intervention effectiveness in scrubbing COVID-19 and its pros and cons on educational activity in Dire Dawa City., Methods: Stratified random sampling was hired to draw a sample of teachers from a list of teachers that were taught at both selected private and public educational institutes., Results: A 57.6% of educators responded as the government was effective in mitigating the pandemic. Out of 250 educators, 9.6%, 10.8%, 8.4%, 38.4%, and 32.8% were reported that they have very poor, poor, neutral, good, and very good level of knowledge about COVID-19, respectively. The respondents' perceptions about the pandemic were rated as not very fear inducing, not fear inducing, neutral, fear inducing, and very fear inducing 3.2%, 6.4%, 6.8%, 55.2% and 28.4%, respectively. Logistic regression indicates nine predictors were significant: avoiding touching one's body with unwashed hands, disinfecting surfaces, fatigue, getting flu vaccine, individual limitation in cooperating to cease the disease, how to maintain one's mental health during the isolation, and washing for at least 20 seconds, family care, and self-isolation., Pros: Reading, family care, watching movies and physical exercise were importance brought by the pandemic to the educators., Cons: Teachers are obligated to stay at home, unemployment, stress, unable to conduct professional activities, cancellation of training, and loss of motivation., Conclusion: The results implied us eighty-four variables were significantly associated with government intervention effectiveness, and nine predictors were significantly related with the government's intervention effectiveness in halting the pandemic from logistic regression model., Competing Interests: The authors declare that they have no conflicts of interest in this study., (© 2021 Tesfaye Yifru et al.)

This study was conducted in Somodo Watershed to investigate the land-use practices and its effect on species diversity and selected soil properties. Field observation was carried out to identify existing land-use practices following a transect line. A total of 20 plots (10 × 10) m2 were sampled from plots exhibiting different land-use practices found in the watershed in order to evaluate species richness and diversity. Soil samples were also collected from each plot. The soil samples were analyzed following standard laboratory procedures. The result of the analysis showed that there was a significant difference (p<0.05) in species diversity and richness among different land-use practices. Coffea arabica was dominant in homestead gardens and natural forests while Grevillea robusta showed had maximum richness in plantations and farm forests in the Watershed. Furthermore, home garden agroforestry practice was significantly (p<0.05) affected soil pH compared to other land-use systems (cultivated land, natural forest, and plantation forest. While Organic carbon (OC), Total nitrogen (TN), and Carbon to Nitrogen ratio (C: N) did not show significance difference among land-use systems in the watershed. The study has concluded that different land-use practices had a positive impact on sustaining species diversity, richness, and improve soil properties. Therefore, the study suggests that improving and expanding home garden agroforestry practices in the area are indispensable for environmental protection and soil fertility enhancement., Competing Interests: The authors have declared that no competing interests exist.

Background: Sub-Saharan Africa shares a disproportionately large ratio of the global acute disease burden, however epidemiological data specific to the burden of emergency conditions are lacking. This study aimed to determine the morbidity burden of emergency conditions in Jimma city, Southwest Ethiopia., Methods: A cross-sectional study was conducted using emergency case registries of three years from 2014 to 2017, at Jimma Medical Center and Shenen Gibe Hospital. 39,537 emergency visits were included in the study. The data were exported to SPSS V.23.0 for statistical analysis, descriptive analysis was used to summarize demographic characteristics, causes of visit, and morbidity rates. Findings were integrated with population-based health demographic reports quantifying the morbidity burden. Outcome measures were overall number of emergency visits and morbidity rates for the population groups., Results: From a total of 39,537 visits, those between 15 and 29 years of age accounted for 42.1% (n = 16615), and 50.6% (n = 20004) were females. Communicable, Maternal, Neonatal and Nutritional (CMNNs) conditions accounted for 57.2%(n = 22597), followed by injuries (22.9%, n = 9055). Top five conditions were non-specific trauma (2.3%, n = 4861), complicated labor (8.4%, n = 3320), lower respiratory infections (8.1%, n = 3213), acute febrile illness (6.6%, n = 2600), and neonatal infections (3.7%, n = 1444)., Conclusion: The burden of acute conditions presented to public hospitals in Jimma city is high. Traumatic injuries, obstetric emergencies, lower respiratory infections, and neonatal emergencies were the most frequent causes of acute visits. An appropriate emergency care system that addresses this high burden of acute emergencies should be established in the study area., (Copyright © 2020 Elsevier Ltd. All rights reserved.)

Background: Anemia defined as a low blood hemoglobin concentration is public health importance. The adolescence age group is the most neglected in public health and nutrition research as priorities are usually given to pregnant women, lactating mothers, and their children less than 2 years. Current Ethiopian Food and Nutrition policy included adolescent girls in the most at-risk group for nutritional demands; however, only a few published studies have assessed a deficiency of anemia and associated factors to tackle the intergenerational cycle of malnutrition., Objective: To assess the prevalence of anemia and associated factors among high school adolescent girls in Jimma town., Methods: Data were collected from 528 secondary school adolescent girls by a school-based cross-sectional study design in Jimma town from 1/1/2019 to 1/2/2019, southwest Ethiopia. A multistage sampling technique was used to select the study participants. A portable battery-operated HemoCue Hb 301+ analyzer was used to measure the hemoglobin level, and then reading was classified as normal Hb ≥ 12 g\dl and anemic if the hemoglobin value <12 g/dl based on the WHO 2011 recommended cutoff points after adjustments to altitude was made. Bivariate analysis at p value ≤0.25 was considered as a candidate for multivariable logistic regression. Multivariable logistic regression was done to control for confounders and to identify factors independently associated with anemia. Level of statistical significance was declared at p < 0.05., Results: A total of 528 adolescent girls were included in the study yielding a response rate of 95.8%. The prevalence of anemia was found to be 26.7%, 95% CI (22.7, 30.50). In multivariate logistic regression analysis, those living separately from their family (AOR = 4.430, 95% CI (2.20, 8.90)), low dietary diversity score (AOR = 3.57, 95% CI (1.88, 6.75)), menstrual bleeding more than 5 days (AOR = 2.25, 95% CI (1.17, 4.33)), and low economic status (AOR = 2.16, 95% CI (1.17, 4.33)) were positively associated factors with anemia and only having at least a secondary school in mother's educational status AOR = 0.43, 95% CI (0.18, 0.97) was negatively associated with anemia in the study area., Conclusion: Prevalence of anemia among school adolescent girls was moderate public health importance according to the World Health Organization prevalence estimation of anemia. The living condition of the adolescent girls, dietary diversity score, duration of menses, and low economic status were positive predictor variables, whereas mothers who are being secondary school and above was a protective factor for anemia. Therefore, iron-rich and diversified food consumption should be given attention., Competing Interests: The authors report no conflicts of interest in this work., (Copyright © 2020 Kelemu Fentie et al.)

Background: Salmonella and Shigella infections are a common public health problem throughout the world. The risk of getting infections is high, where asymptomatic street food vendors are preparing foods and vending. Current knowledge of antimicrobial susceptibility pattern is essential for appropriate treatment and management of these infections., Objective: This study was aimed to determine the prevalence, antimicrobial susceptibility pattern, and associated factors of Salmonella and Shigella among asymptomatic street food vendors in the Dire Dawa city, Eastern Ethiopia., Methods: A cross-sectional study was conducted among 218 randomly selected asymptomatic street food vendors in the Dire Dawa city, Eastern Ethiopia from May to July 2017. Data on the sociodemographic and associated factors were collected using a pretested structured questionnaire. The stool specimens collected were examined for Salmonella and Shigella using recommended culture methods. The antimicrobial susceptibility test was done using the disk diffusion technique. Data were described using descriptive statistical tools. Logistic regression models were used to identify the factors associated with Salmonella and Shigella infections. A P -value ⩽ .05 was considered statistically significant., Results: The overall prevalence of Salmonella and Shigella was 8.7% (95% confidence interval: 5.6, 10.3). The most common isolates were Salmonella (6%). Most of the isolates were resistant to amoxicillin (97.7%), ampicillin (89.5%), and tetracycline (68.4%). Almost half (47.4%) of Salmonella isolates were multidrug resistant. Food vendors who did not wash hands with soap after the use of the toilet (adjusted odds ratio: 3.3, 95% confidence interval: 1.2, 7.9), and who had untrimmed fingernails (adjusted odds ratio: 4.4, 95% confidence interval: 1.5, 9.3) had higher odds of Salmonella and Shigella compared with their counterparts., Conclusions: The carrier rate of Salmonella and Shigella was relatively low. Most isolates have developed resistance to amoxicillin, ampicillin, and tetracycline. The odds of Salmonella and Shigella was high among those who lack a habit of hand washing with soap after the use of the toilet and with untrimmed fingernails. Regular screening and appropriate hygienic control measures are needed in place to reduce the risk of infections., Competing Interests: Declaration of conflicting interests:The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Objective: S. pneumoniae responsible for a range of respiratory infections from uncomplicated to severe invasive pneumococcal disease. Nasopharyngeal specimens were collected from children attending kindergarten and aged ≤ 6 years from February, 2017 to June, 2017 to assess the nasopharyngeal carriage and antimicrobial susceptibility pattern of S. pneumoniae. Parents of children interviewed using questionnaire and check list to identify associated factors. An antimicrobial susceptibility test performed using disk diffusion method., Results: Overall pneumococcal carriage were 18.4% (88/477). No significant variation in colonization based on sex and age of children. Children living with siblings (1-2) < 6 years in household (adjusted odd ratio = 16.06; 95% confidence interval 6.21-41.55) and > 5 person per household (adjusted odd ratio = 3.27; 95% confidence interval 1.50-7.14) were associated with higher S. pneumoniae carriage. Non- exclusive breast feeding (adjust odd ratio = 6.00; 95% confidence interval 3.33-10.80) and horse cart transportation (adjusted odd ratio = 2.75; 95% confidence interval 1.05-7.22) increases carriage. S. pneumoniae showed 21 (23.9%) resistance to erythromycin, 18 (20.4%) to amoxicillin, 13 (15.0%) to penicillin, and the least 1 (1.1%) to augmentin.

Background: Substantial evidence is emerging on the coexistence of double burden of malnutrition on adolescents of low-income countries, shaping the health challenges of the upcoming adult generation for the worst. Whether nutritional status markers of adolescents in the cash crop setting are on par with economic gains remains uncertain. Thus, we investigated the nutritional outcomes of adolescents and their determinants in coffee farming households., Methods: The survey was carried out in 3 top coffee-producing districts of Jimma Zone, Ethiopia. Five hundred fifty mothers/caregivers and their respective adolescents were selected using multistage random sampling. Anthropometric data were converted into height-for-age and body-mass-index-for-age Z scores using WHO Anthroplus software and analyzed by SPSS for windows., Results: Prevalence of thinness, stunting, and overweight/obesity were 11.6%, 15.6%, and 7.1%, respectively. The odds of stunting among adolescents in households in the lowest wealth tertile was nearly 6-fold higher compared to the highest tertile (adjusted odds ratio [AOR] = 5.6 [2.6-12]). Conversely, the odds of overweight/obesity was higher among adolescents in the households in the middle wealth tertile (AOR = 2.72 [1.08-6.86]) compared to the highest tertile. Adolescents living in households with low-dependent age-groups were more than twice likely to be overweight/obese (AOR = 2.58 [1.06-6.24])., Conclusion: The current study revealed the presence of substantial dual burden of malnutrition. In such a setting, it is critical to draw a fine line and trade-off for eliminating morbidity and mortality of undernutrition, without triggering the risk of overweight/obesity.

Background: The global incidence of breast cancer (BC) is rising, especially in low- and middle-income countries. The purpose of this review is to summarize existing publications on BC care in Africa., Patients and Methods: A systematic search in MEDLINE and smaller databases was carried out to identify African studies on BC treatment, and an additional PubMed search was performed for relevant topics on BC care., Results: A total of 219 publications, mainly from North and West Africa, were found by systematic search. We also selected articles on BC epidemiology, risk factors, clinical presentation, and cancer control in Africa., Conclusions: Publications on BC treatment are mostly from hospital case series. Evidence on treatment from prospective randomized trials that address the specific characteristics of African patients is lacking. The epidemiologic data shows rising incidences in Africa. The prevalence of risk factors is changing by age group, geographic region, and over time. The clinical picture of BC differs from that of Western countries due to the high proportion of young patients (on account of the African population with a high proportion of young people) and late presentation. Global collaborative efforts are needed to address the rising need for improved BC care in Africa.

Background: Tuberculosis is the leading causes of mortality among infectious diseases worldwide. The risk of transmission from patients to health workers is doubles that of the general population. The close contact to the infectious case before diagnosis is the major risk for tuberculosis infection. The aim of the study was to assess knowledge and practice of health professionals towards tuberculosis infection control and its associated factors in health facilities of Addis Ababa, Ethiopia., Methods: A cross-sectional study was conducted from February 29 to April 15/2014 in selected health facilities in Addis Ababa. Five hundred ninety health workers were included in the study. The sample size was assigned to each health facility proportional to their number of health workers. Study subjects were selected from each stratum by simple random sampling technique. Interviewer administered structured questionnaire was used to collect information. Logistic regression was used to identify factors associated with knowledge and practice of health workers towards tuberculosis infection control., Result: Five hundred eighty two participants with 98.6% response rate were involved in the study. Of these, 36.1% had poor knowledge and 51.7% unsatisfactory practice score towards tuberculosis infection control. Having more than six years working experience in health facility (AOR = 2.51; 95% CI: 1.5-4.1) and tuberculosis related training (AOR = 2.51 95% CI; 1.5, 4.1) were significantly associated with knowledge on tuberculosis infection control. Having experience in tuberculosis clinic (AOR =1.93; 95% CI: 1.12, 3.34) and tuberculosis related training (AOR = 1.48; 95% CI: 1.87, 2.51) were significantly associated with practice on tuberculosis infection control., Conclusion: One third of health workers had relatively poor knowledge and nearly half of them had unsatisfactory practice on tuberculosis infection control. Tuberculosis training and work experiences in health facility are determinant factor to knowledge. Whereas tuberculosis related training and experience in tuberculosis clinic are predictor to practice. So, training of the health professionals, on job orientations of junior health workers, and farther study including private health workers are recommended.