30 results on '"Giusti, Sebastian A."'
Search Results
2. A brain-enriched circular RNA controls excitatory neurotransmission and restricts sensitivity to aversive stimuli
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Giusti, Sebastian A., primary, Pino, Natalia S., additional, Pannunzio, Camila, additional, Ogando, Mora B., additional, Armando, Natalia G., additional, Garrett, Lillian, additional, Zimprich, Annemarie, additional, Becker, Lore, additional, Gimeno, Maria L., additional, Lukin, Jeronimo, additional, Merino, Florencia L., additional, Pardi, M. Belen, additional, Pedroncini, Olivia, additional, Di Mauro, Giuliana C., additional, Durner, Valerie Gailus, additional, Fuchs, Helmut, additional, de Angelis, Martin Hrabe, additional, Patop, Ines L., additional, Turck, Christoph W., additional, Deussing, Jan M., additional, Vogt Weisenhorn, Daniela M., additional, Jahn, Olaf, additional, Kadener, Sebastian, additional, Hölter, Sabine M., additional, Brose, Nils, additional, Giesert, Florian, additional, Wurst, Wolfgang, additional, Marin-Burgin, Antonia, additional, and Refojo, Damian, additional
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- 2024
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3. Optimal Topological Design of a Thermal Isolator for a Monopropellant Space Thruster
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Giusti, Sebastián Miguel, Romero, Augusto Alejandro, Salomone, Javier Eduardo, Pardalos, Panos M., Managing Editor, Du, Ding-Zhu, Honorary Editor, Birge, John, Advisory Editor, Butenko, Sergiy, Advisory Editor, Giannessi, Franco, Advisory Editor, Rebennack, Steffen, Advisory Editor, Terlaky, Tamás, Advisory Editor, Ye, Yinyu, Advisory Editor, Fasano, Giorgio, editor, and Pintér, János D., editor
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- 2019
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4. Global site-specific neddylation profiling reveals that NEDDylated cofilin regulates actin dynamics
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Vogl, Annette M., Phu, Lilian, Becerra, Raquel, Giusti, Sebastian A., Verschueren, Erik, Hinkle, Trent B., Bordenave, Martín D., Adrian, Max, Heidersbach, Amy, Yankilevich, Patricio, Stefani, Fernando D., Wurst, Wolfgang, Hoogenraad, Casper C., Kirkpatrick, Donald S., Refojo, Damian, and Sheng, Morgan
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- 2020
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5. Guest editorial
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Novotny, Antonio Andre, Giusti, Sebastian Miguel, and Amstutz, Samuel
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- 2022
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6. An objective multi-scale model with hybrid injection
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Labanda, Nicolás A., Giusti, Sebastián M., and Luccioni, Bibiana M.
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- 2018
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7. A path-following technique implemented in a Lagrangian formulation to model quasi-brittle fracture
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Labanda, Nicolás A., Giusti, Sebastián M., and Luccioni, Bibiana M.
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- 2018
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8. Multi-objective Topology Optimization Design of Micro-structures
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Giusti, Sebastián Miguel, Novotny, Antonio André, Öchsner, Andreas, Series editor, da Silva, Lucas F. M., Series editor, Altenbach, Holm, Series editor, and Muñoz-Rojas, Pablo Andrés, editor
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- 2016
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9. Behavioral phenotyping of Nestin-Cre mice: Implications for genetic mouse models of psychiatric disorders
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Giusti, Sebastian A., Vercelli, Claudia A., Vogl, Annette M., Kolarz, Adam W., Pino, Natalia S., Deussing, Jan M., and Refojo, Damian
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- 2014
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10. Topology design of plates considering different volume control methods
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Esteves Campeão, Diego, Miguel Giusti, Sebastian, and Antonio Novotny, Andre
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- 2014
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11. Sensitivity of the macroscopic response of elastic microstructures to the insertion of inclusions
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Giusti, Sebastián M., Novotny, Antonio A., and de Souza Neto, Eduardo A.
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- 2010
12. Inverse homogenization using the topological derivative
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Universitat Politècnica de Catalunya. Departament de Física, Universitat Politècnica de Catalunya. ANiComp - Anàlisi numèrica i computació científica, Ferrer Ferré, Àlex, Giusti, Sebastian Miguel, Universitat Politècnica de Catalunya. Departament de Física, Universitat Politècnica de Catalunya. ANiComp - Anàlisi numèrica i computació científica, Ferrer Ferré, Àlex, and Giusti, Sebastian Miguel
- Abstract
Purpose: The purpose of this study is to solve the inverse homogenization problem, or so-called material design problem, using the topological derivative concept. Design/methodology/approach : The optimal topology is obtained through a relaxed formulation of the problem by replacing the characteristic function with a continuous design variable, so-called density variable. The constitutive tensor is then parametrized with the density variable through an analytical interpolation scheme that is based on the topological derivative concept. The intermediate values that may appear in the optimal topologies are removed by penalizing the perimeter functional. Findings: The optimization process benefits from the intermediate values that provide the proposed method reaching to solutions that the topological derivative had not been able to find before. In addition, the presented theory opens the path to propose a new framework of research where the topological derivative uses classical optimization algorithms. Originality/value: The proposed methodology allows us to use the topological derivative concept for solving the inverse homogenization problem and to fulfil the optimality conditions of the problem with the use of classical optimization algorithms. The authors solved several material design examples through a projected gradient algorithm to show the advantages of the proposed method., This research was partially supported by Serra Húnter Research Program (Spain), PID-UTN (Research and Development Program of the National Technological University, Argentina) and CONICET (National Council for Scientific and Technical Research, Argentina). The supports of these agencies are gratefully acknowledged., Peer Reviewed, Postprint (author's final draft)
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- 2021
13. Global site-specific neddylation profiling reveals that NEDDylated cofilin regulates actin dynamics
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Celbiologie, Sub Cell Biology, Vogl, Annette M., Phu, Lilian, Becerra, Raquel, Giusti, Sebastian A., Verschueren, Erik, Hinkle, Trent B., Bordenave, Martín D., Adrian, Max, Heidersbach, Amy, Yankilevich, Patricio, Stefani, Fernando D., Wurst, Wolfgang, Hoogenraad, Casper C., Kirkpatrick, Donald S., Refojo, Damian, Sheng, Morgan, Celbiologie, Sub Cell Biology, Vogl, Annette M., Phu, Lilian, Becerra, Raquel, Giusti, Sebastian A., Verschueren, Erik, Hinkle, Trent B., Bordenave, Martín D., Adrian, Max, Heidersbach, Amy, Yankilevich, Patricio, Stefani, Fernando D., Wurst, Wolfgang, Hoogenraad, Casper C., Kirkpatrick, Donald S., Refojo, Damian, and Sheng, Morgan
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- 2020
14. Publisher Correction: Global site-specific neddylation profiling reveals that NEDDylated cofilin regulates actin dynamics
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Vogl, Annette M., primary, Phu, Lilian, additional, Becerra, Raquel, additional, Giusti, Sebastian A., additional, Verschueren, Erik, additional, Hinkle, Trent B., additional, Bordenave, Martín D., additional, Adrian, Max, additional, Heidersbach, Amy, additional, Yankilevich, Patricio, additional, Stefani, Fernando D., additional, Wurst, Wolfgang, additional, Hoogenraad, Casper C., additional, Kirkpatrick, Donald S., additional, Refojo, Damian, additional, and Sheng, Morgan, additional
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- 2020
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15. On multi-scale computational design of structural materials using the topological derivative
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Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. Departament de Física, Universitat Politècnica de Catalunya. RMEE - Grup de Resistència de Materials i Estructures en l'Enginyeria, Oliver Olivella, Xavier, Ferrer Ferré, Àlex, Cante Terán, Juan Carlos, Giusti, Sebastian Miguel, Lloberas Valls, Oriol, Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. Departament de Física, Universitat Politècnica de Catalunya. RMEE - Grup de Resistència de Materials i Estructures en l'Enginyeria, Oliver Olivella, Xavier, Ferrer Ferré, Àlex, Cante Terán, Juan Carlos, Giusti, Sebastian Miguel, and Lloberas Valls, Oriol
- Abstract
This book brings together some 20 chapters on state-of-the-art research in the broad field of computational plasticity with applications in civil and mechanical engineering, metal forming processes, geomechanics, nonlinear structural analysis, composites, biomechanics and multi-scale analysis of materials, among others. The chapters are written by world leaders in the different fields of computational plasticity., Peer Reviewed, Postprint (author's final draft)
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- 2017
16. Topological sensitivity analysis in heterogeneous anisotropic elasticity problem: theoretical and computational aspects
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Universitat Politècnica de Catalunya. Departament de Física, Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. RMEE - Grup de Resistència de Materials i Estructures en l'Enginyeria, Giusti, Sebastian Miguel, Ferrer Ferré, Àlex, Oliver Olivella, Xavier, Universitat Politècnica de Catalunya. Departament de Física, Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. RMEE - Grup de Resistència de Materials i Estructures en l'Enginyeria, Giusti, Sebastian Miguel, Ferrer Ferré, Àlex, and Oliver Olivella, Xavier
- Abstract
The topological sensitivity analysis for the heterogeneous and anisotropic elasticity problem in two-dimensions is performed in this work. The main result of the paper is an analytical closed-form of the topological derivative for the total potential energy of the problem. This derivative displays the sensitivity of the cost functional (the energy in this case) when a small singular perturbation is introduced in an arbitrary point of the domain. In this case, we consider a small disc with a completely different elastic material. Full mathematical justification for the derived formula, and derivations of precise estimates for the remainders of the topological asymptotic expansion are provided. Finally, the influence of the heterogeneity and anisotropy is shown through some numerical examples of structural topology optimization., Peer Reviewed, Postprint (author's final draft)
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- 2016
17. A two-scale failure model for heterogeneous materials: Numerical implementation based on the finite element method
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Toro, Sebastian, Sánchez, Pablo Javier, Huespe, Alfredo Edmundo, Giusti, Sebastian Miguel, Blanco, Pablo Antonio, and Feijóo, Raúl Antonino
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COHESIVE MODELS ,FAILURE MODELING OF HETEROGENEOUS MATERIALS ,REPRESENTATIVE VOLUME ELEMENT (RVE) ,MULTISCALE FORMULATIONS ,COMPUTATIONAL HOMOGENIZATION - Abstract
In the first part of this contribution, a brief theoretical revision of the mechanical and variational foundations of a Failure-Oriented Multiscale Formulation devised for modeling failure in heterogeneous materials is described. The proposed model considers two well separated physical length scales, namely: (i) the macroscale where nucleation and evolution of a cohesive surface is considered as a medium to characterize the degradation phenomenon occurring at the lower length scale, and (ii) the microscale where some mechanical processes that lead to the material failure are taking place, such as strain localization, damage, shear band formation, and so on. These processes are modeled using the concept of Representative Volume Element (RVE). On the macroscale, the traction separation response, characterizing the mechanical behavior of the cohesive interface, is a result of the failure processes simulated in the microscale. The traction separation response is obtained by a particular homogenization technique applied on specific RVE sub-domains. Standard, as well as, Non-Standard boundary conditions are consistently derived in order to preserve objectivity of the homogenized response with respect to the micro-cell size. In the second part of the paper, and as an original contribution, the detailed numerical implementation of the two-scale model based on the finite element method is presented. Special attention is devoted to the topics, which are distinctive of the Failure-Oriented Multiscale Formulation, such as: (i) the finite element technologies adopted in each scale along with their corresponding algorithmic expressions, (ii) the generalized treatment given to the kinematical boundary conditions in the RVE, and (iii) how these kinematical restrictions affect the capturing of macroscopic material instability modes and the posterior evolution of failure at the RVE level. Finally, a set of numerical simulations is performed in order to show the potentialities of the proposed methodology, as well as, to compare and validate the numerical solutions furnished by the two-scale model with respect to a direct numerical simulation approach. Fil: Toro, Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones en Métodos Computacionales. Universidad Nacional del Litoral. Centro de Investigaciones en Métodos Computacionales; Argentina Fil: Sánchez, Pablo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones en Métodos Computacionales. Universidad Nacional del Litoral. Centro de Investigaciones en Métodos Computacionales; Argentina Fil: Huespe, Alfredo Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones en Métodos Computacionales. Universidad Nacional del Litoral. Centro de Investigaciones en Métodos Computacionales; Argentina Fil: Giusti, Sebastian Miguel. Universidad Tecnológica Nacional. Facultad Regional Córdoba; Argentina Fil: Blanco, Pablo Antonio. Laboratorio Nacional de Computacao Cientifica; Brasil Fil: Feijóo, Raúl Antonino. Laboratorio Nacional de Computacao Cientifica; Brasil
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- 2014
18. Topology design of elastic structures for a contact model
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Giusti, Sebastian M., Sokolowski, Jan, Stebel, Jan, Universidad Nacional de Córdoba [Argentina], Institut Élie Cartan de Lorraine (IECL), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Mathematical Institute [Praha] - Academy of Sciences, and Czech Academy of Sciences [Prague] (CAS)
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Topological optimization ,[MATH.MATH-GM]Mathematics [math]/General Mathematics [math.GM] ,Frictionless contact problem ,Asymptotic analysis ,Topological derivative ,Optimum design problems - Abstract
International audience; Contact problems are very important in the engineering design and the correct interpretation of the physical phenomena, and its influence in this process, is of paramount importance for the engineers. In this paper we employ the topological derivative concept for optimum design problems in contact solid mechanics. A nonlinear contact model governed by a variational inequality is considered. Beside the theoretical developments, some computational examples are included. The influence of the parameters of the contact model in the optimal results for the structures is studied. The numerical results show that the proposed method of optimum design can be applied to a broad class of engineering problems.
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- 2014
19. Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed
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Rybak-Wolf, Agnieszka, Stottmeister, Christin, Glazar, Petar, Jens, Marvin, Pino, Natalia, Giusti, Sebastian, Hanan, Mor, Behm, Mikaela, Bartok, Osnat, Ashwal-Fluss, Reut, Herzog, Margareta, Schreyer, Luisa, Papavasileiou, Panagiotis, Ivanov, Andranik, Öhman, Marie, Refojo, Damian, Kadener, Sebastian, Rajewsky, Nikolaus, Rybak-Wolf, Agnieszka, Stottmeister, Christin, Glazar, Petar, Jens, Marvin, Pino, Natalia, Giusti, Sebastian, Hanan, Mor, Behm, Mikaela, Bartok, Osnat, Ashwal-Fluss, Reut, Herzog, Margareta, Schreyer, Luisa, Papavasileiou, Panagiotis, Ivanov, Andranik, Öhman, Marie, Refojo, Damian, Kadener, Sebastian, and Rajewsky, Nikolaus
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Circular RNAs (circRNAs) are an endogenous class of animal RNAs. Despite their abundance, their function and expression in the nervous system are unknown. Therefore, we sequenced RNA from different brain regions, primary neurons, isolated synapses, as well as during neuronal differentiation. Using these and other available data, we discovered and analyzed thousands of neuronal human and mouse circRNAs. circRNAs were extraordinarily enriched in the mammalian brain, well conserved in sequence, often expressed as circRNAs in both human and mouse, and sometimes even detected in Drosophila brains. circRNAs were overall upregulated during neuronal differentiation, highly enriched in synapses, and often differentially expressed compared to their mRNA isoforms. circRNA expression correlated negatively with expression of the RNA-editing enzyme ADAR1. Knockdown of ADAR1 induced elevated circRNA expression. Together, we provide a circRNA brain expression atlas and evidence for important circRNA functions and values as biomarkers.
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- 2015
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20. On topological derivative for contact problem in elasticity
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Giusti, Sebastian, Sokolowski, Jan, Stebel, Jan, Sokolowski, Jan, Universidad Tecnologica Nacional [Cordoba] (UTN-FRC), Institut Élie Cartan de Nancy (IECN), Institut National de Recherche en Informatique et en Automatique (Inria)-Université Henri Poincaré - Nancy 1 (UHP)-Université Nancy 2-Institut National Polytechnique de Lorraine (INPL)-Centre National de la Recherche Scientifique (CNRS), Mathematical Institute [Praha] - Academy of Sciences, Czech Academy of Sciences [Prague] (CAS), and LabEx CARMIN--CIMPA SMV, ESF grant Optimization with PDE Constraints
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asymptotic analysis ,domain decomposition ,static frictionless contact problem ,41A60, 49J52, 49Q10, 35J50, 35Q93 ,[MATH.MATH-AP]Mathematics [math]/Analysis of PDEs [math.AP] ,Topological derivative ,Steklov-Poincaré operator ,[MATH.MATH-AP] Mathematics [math]/Analysis of PDEs [math.AP] - Abstract
In the paper the general method for shape-topology sensitivity analysis of contact problems is proposed. The method uses the domain decomposition method combined with the specific properties of minimizers for the energy functional. The method is applied to the static problem of an elastic body in frictionless contact with an rigid foundation. The contact model allows a finite interpenetration of the bodies on the contact region. This interpenetration is modeled by means of a scalar function that depends on the normal component of the displacement field on the potential contact zone. We present the asymptotic behavior of the energy shape functional when a spheroidal void is introduced in an arbitrary point of the elastic body. For the asymptotic analysis, we use the domain decomposition technique and the associated Steklov-Poincaré pseudodifferential operator. The differentiability of the energy with respect to the non-smooth perturbation is established. A closed form for the topological derivative is also presented.
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- 2012
21. Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed
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Rybak-Wolf, Agnieszka, primary, Stottmeister, Christin, additional, Glažar, Petar, additional, Jens, Marvin, additional, Pino, Natalia, additional, Giusti, Sebastian, additional, Hanan, Mor, additional, Behm, Mikaela, additional, Bartok, Osnat, additional, Ashwal-Fluss, Reut, additional, Herzog, Margareta, additional, Schreyer, Luisa, additional, Papavasileiou, Panagiotis, additional, Ivanov, Andranik, additional, Öhman, Marie, additional, Refojo, Damian, additional, Kadener, Sebastian, additional, and Rajewsky, Nikolaus, additional
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- 2015
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22. Neddylation inhibition impairs spine development, destabilizes synapses and deteriorates cognition
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Vogl, Annette M, primary, Brockmann, Marisa M, additional, Giusti, Sebastian A, additional, Maccarrone, Giuseppina, additional, Vercelli, Claudia A, additional, Bauder, Corinna A, additional, Richter, Julia S, additional, Roselli, Francesco, additional, Hafner, Anne-Sophie, additional, Dedic, Nina, additional, Wotjak, Carsten T, additional, Vogt-Weisenhorn, Daniela M, additional, Choquet, Daniel, additional, Turck, Christoph W, additional, Stein, Valentin, additional, Deussing, Jan M, additional, and Refojo, Damian, additional
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- 2015
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23. Topological derivative-based optimization of micro-structures considering different multi-scale models
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De Souza Neto, Eduardo Alberto, Amstutz, Samuel, Giusti, Sebastian Miguel, and Novotny, Antonio André
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purl.org/becyt/ford/1 [https] ,purl.org/becyt/ford/2 [https] ,OTIMIZATION OF MICRO-STRUCTURES ,MULTI-SCALE MODELLING ,purl.org/becyt/ford/1.1 [https] ,SYNTHESIS OF MICRO-STRUCTURES ,SENSITIVITY ANALYSIS ,purl.org/becyt/ford/2.1 [https] ,TOPOLOGICAL DERIVATIVE ,purl.org/becyt/ford/2.5 [https] - Abstract
A recently proposed algorithm for micro-structural optimization, based on the concept of topological derivative and a level-set domain representation, is applied to the synthesis of elastic and heat conducting bi-material micro-structures. The macroscopic properties are estimated by means of a family of multi-scale constitutive theories where the macroscopic strain and stress tensors (temperature gradient and heat flux vector in the heat conducting case) are defined as volume averages of their microscopic counterparts over a Representative Volume Element (RVE). Several finite element-based examples of micro-structural optimization are presented. Three multi-scale models, providing an upper and a lower bound for the macroscopic properties as well as the classical periodic medium solution, are considered in the optimization process. These models differ only in the kinematical constraints (thermal constraints in the heat conducting case) imposed on the RVE. The examples show that, in general, the obtained optimum micro-structure topology depends on the particular model adopted. Fil: De Souza Neto, Eduardo Alberto. Swansea University; Reino Unido Fil: Amstutz, Samuel. No especifíca; Fil: Giusti, Sebastian Miguel. Laboratório Nacional de Computação Científica; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina Fil: Novotny, Antonio André. Laboratório Nacional de Computação Científica; Brasil
- Published
- 2010
24. A two-scale failure model for heterogeneous materials: numerical implementation based on the finite element method
- Author
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Universitat Politècnica de Catalunya. Departament de Resistència de Materials i Estructures a l'Enginyeria, Universitat Politècnica de Catalunya. RMEE - Grup de Resistència de Materials i Estructures en l'Enginyeria, Toro, Sebastian, Sánchez, Pablo J., Huespe, Alfredo Edmundo, Giusti, Sebastian Miguel, Blanco, Pedro J., Feijóo, R.A., Universitat Politècnica de Catalunya. Departament de Resistència de Materials i Estructures a l'Enginyeria, Universitat Politècnica de Catalunya. RMEE - Grup de Resistència de Materials i Estructures en l'Enginyeria, Toro, Sebastian, Sánchez, Pablo J., Huespe, Alfredo Edmundo, Giusti, Sebastian Miguel, Blanco, Pedro J., and Feijóo, R.A.
- Abstract
This is the accepted version of the following article: Toro, S., Sánchez, P.J., Huespe, A.E., Giusti, S.M., Blanco, P.J. and Feijóo, R.A. (2014), A two-scale failure model for heterogeneous materials: numerical implementation based on the finite element method. Int. J. Numer. Meth. Engng., 97: 313–351. doi: 10.1002/nme.4576, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/nme.4576/abstract, In the first part of this contribution, a brief theoretical revision of the mechanical and variational foundations of a Failure-Oriented Multiscale Formulation (FOMF) devised for modeling failure in heterogeneous materials is described. The proposed model considers two well separated physical length scales, namely: (i) the “macro” scale where nucleation and evolution of a cohesive surface is considered as a medium to characterize the degradation phenomenon occurring at the lower length scale, and (ii) the “micro” scale where some mechanical processes that lead to the material failure are taking place, such as strain localization, damage, shear band formation, etc. These processes are modeled using the concept of Representative Volume Element (RVE). On the macro scale, the traction separation response, characterizing the mechanical behavior of the cohesive interface, is a result of the failure processes simulated in the micro scale. The traction separation response is obtained by a particular homogenization technique applied on specific RVE subdomains. Standard, as well as, Non-Standard boundary conditions are consistently derived in order to preserve “objectivity” of the homogenized response with respect to the micro-cell size. In the second part of the paper, and as an original contribution, the detailed numerical implementation of the two-scale model based on the Finite Element Method is presented. Special attention is devoted to the topics which are distinctive of the FOMF, such as: (i) the finite element technologies adopted in each scale along with their corresponding algorithmic expressions, (ii) the generalized treatment given to the kinematical boundary conditions in the RVE and (iii) how these kinematical restrictions affect the capturing of macroscopic material instability modes and the posterior evolution of failure at the RVE level. Finally, a set of numerical simulations is performed., Peer Reviewed, Postprint (author’s final draft)
- Published
- 2014
25. MicroRNA-9 controls dendritic development by targeting REST
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Giusti, Sebastian A, primary, Vogl, Annette M, additional, Brockmann, Marisa M, additional, Vercelli, Claudia A, additional, Rein, Martin L, additional, Trümbach, Dietrich, additional, Wurst, Wolfgang, additional, Cazalla, Demian, additional, Stein, Valentin, additional, Deussing, Jan M, additional, and Refojo, Damian, additional
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- 2014
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26. Author response: MicroRNA-9 controls dendritic development by targeting REST
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Giusti, Sebastian A, primary, Vogl, Annette M, additional, Brockmann, Marisa M, additional, Vercelli, Claudia A, additional, Rein, Martin L, additional, Trümbach, Dietrich, additional, Wurst, Wolfgang, additional, Cazalla, Demian, additional, Stein, Valentin, additional, Deussing, Jan M, additional, and Refojo, Damian, additional
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- 2014
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27. MicroRNA-9 promotes the switch from early-born to late-born motor neuron populations by regulating Onecut transcription factor expression
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Luxenhofer, Georg, primary, Helmbrecht, Michaela S., additional, Langhoff, Jana, additional, Giusti, Sebastian A., additional, Refojo, Damian, additional, and Huber, Andrea B., additional
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- 2014
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28. Topology design of plates considering different volume control methods.
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Campeão, Diego Esteves, Giusti, Sebastian Miguel, and Novotny, Andre Antonio
- Subjects
- *
PLATES (Engineering) design & construction , *STRUCTURAL optimization , *KIRCHHOFF'S theory of diffraction , *COMPUTER-aided design , *LAGRANGIAN mechanics - Abstract
Purpose – The purpose of this paper is to compare between two methods of volume control in the context of topological derivative-based structural optimization of Kirchhoff plates. Design/methodology/approach – The compliance topology optimization of Kirchhoff plates subjected to volume constraint is considered. In order to impose the volume constraint, two methods are presented. The first one is done by means of a linear penalization method. In this case, the penalty parameter is the coefficient of a linear term used to control the amount of material to be removed. The second approach is based on the Augmented Lagrangian method which has both, linear and quadratic terms. The coefficient of the quadratic part controls the Lagrange multiplier update of the linear part. The associated topological sensitivity is used to devise a structural design algorithm based on the topological derivative and a level-set domain representation method. Finally, some numerical experiments are presented allowing for a comparative analysis between the two methods of volume control from a qualitative point of view. Findings – The linear penalization method does not provide direct control over the required volume fraction. In contrast, through the Augmented Lagrangian method it is possible to specify the final amount of material in the optimized structure. Originality/value – A strictly simple topology design algorithm is devised and used in the context of compliance structural optimization of Kirchhoff plates under volume constraint. The proposed computational framework is quite general and can be applied in different engineering problems. [ABSTRACT FROM AUTHOR]
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- 2014
- Full Text
- View/download PDF
29. On multi-scale computational design of structural materials using the topological derivative
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Oliver Olivella, Xavier, Ferrer Ferré, Àlex, Cante Terán, Juan Carlos, Giusti, Sebastian Miguel, Lloberas Valls, Oriol, Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. Departament de Física, and Universitat Politècnica de Catalunya. RMEE - Grup de Resistència de Materials i Estructures en l'Enginyeria
- Subjects
Topological optimization ,Structural optimization--Mathematics ,COMP-DES-MAT Project ,COMPDESMAT Project ,Enginyeria dels materials::Disseny i selecció de materials [Àrees temàtiques de la UPC] ,Topological derivative ,Optimització d'estructures ,Computational vademecum ,Matemàtiques i estadística::Topologia [Àrees temàtiques de la UPC] ,Multi-scale material design - Abstract
This book brings together some 20 chapters on state-of-the-art research in the broad field of computational plasticity with applications in civil and mechanical engineering, metal forming processes, geomechanics, nonlinear structural analysis, composites, biomechanics and multi-scale analysis of materials, among others. The chapters are written by world leaders in the different fields of computational plasticity.
30. Topological sensitive analisys of the Reissner-Mindlin plate bending model
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Rosa, Vitor Sales Dias da, Novotny, Antonio André, Munoz Rivera, Jaime Edilberto, Giusti, Sebastian Miguel, Perla Menzala, Gustavo Alberto, Fancello, Eduardo Alberto, and Duda, Fernando Pereira
- Subjects
Análise assintótica ,Asymptotic analysis ,Derivada topológica ,Topological derivatives ,CIENCIAS EXATAS E DA TERRA::MATEMATICA::ANALISE::EQUACOES DIFERENCIAIS PARCIAIS [CNPQ] ,Equações diferencias parciais ,Partial differential equations - Abstract
Submitted by Maria Cristina (library@lncc.br) on 2015-11-25T12:00:01Z No. of bitstreams: 1 Tese - Análise de Sensibilidade Topológica.pdf: 447139 bytes, checksum: d7d9c80ad59acb3e3cf12ae2d457887f (MD5) Approved for entry into archive by Maria Cristina (library@lncc.br) on 2015-11-25T12:00:22Z (GMT) No. of bitstreams: 1 Tese - Análise de Sensibilidade Topológica.pdf: 447139 bytes, checksum: d7d9c80ad59acb3e3cf12ae2d457887f (MD5) Made available in DSpace on 2015-11-25T12:00:35Z (GMT). No. of bitstreams: 1 Tese - Análise de Sensibilidade Topológica.pdf: 447139 bytes, checksum: d7d9c80ad59acb3e3cf12ae2d457887f (MD5) Previous issue date: 2015-11-03 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Capes) The topological derivative concept has been proved to be useful in many relevant applications such as topology optimization, inverse problems, image processing, multi-scale constitutive modeling, fracture mechanics and damage evolution modeling. The topological asymptotic analysis has been fully developed for a wide range of problems modeled by partial di erential equations. On the other hand, the topological derivatives associated with coupled problems have been derived only in their abstract forms. In this paper, therefore, we deal with the Reissner-Mindlin plate bending model, which is written in the form of a coupled system of partial di erential equations. In particular, the topological asymptotic analysis of the associated total potential energy is developed and the topological derivative with respect to the nucleation of a circular inclusion is derived in its closed form.Finally, we provide the estimates for the remainders of the topological asymptotic expansion and perform a complete mathematical justi cation for the derived formulas. O conceito de derivada topológica tem se mostrado útil em muitas aplicações, tais como otimização topológica, problemas inversos, processamento de imagens, modelagem constitutiva multi-escala, mecânica da fratura e modelagem da evolução de dano. A análise assintótica topológica foi amplamente desenvolvida para uma grande variedade de problemas modelados por equações diferenciais parciais. Por outro lado, a derivada topológica associada a problemas acoplados é conhecida apenas em sua forma abstrata. Neste trabalho, portanto, considera-se o modelo de flexão de placa de Reissner-Mindlin, que é escrito na forma de um sistema acoplado de equações diferenciais parciais. Em particular, a análise assintótica topológica da energia potencial total associada é desenvolvida e a derivada topológica com relação a nucleação de uma inclusão circular é obtida na sua forma fechada. Finalmente, os resíduos da expansão assintótica topológica são estimados e uma justificativa matemática completa para a derivada topológica é apresentada.
- Published
- 2015
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