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9 results on '"Giusepponi, M"'

9. Modulation of pain sensitivity by chronic consumption of highly palatable food followed by abstinence: emerging role of fatty acid amide hydrolase

Author

Giovanna La Rana, Adele Romano, Carlo Cifani, Emanuela Micioni Di Bonaventura, Maria Vittoria Micioni Di Bonaventura, Roberto Russo, Luca Botticelli, Claudia Cristiano, Silvana Gaetani, Antonio Calignano, Carmen De Caro, Carmen Avagliano, Maria Elena Giusepponi, Cifani, C., Avagliano, C., Micioni Di Bonaventura, E., Giusepponi, M. E., De Caro, C., Cristiano, C., La Rana, G., Botticelli, L., Romano, A., Calignano, A., Gaetani, S., Micioni Di Bonaventura, M. V., and Russo, R.

Subjects
0301 basic medicine, medicine.medical_specialty, obesity, Cannabinoid receptor, medicine.medical_treatment, media_common.quotation_subject, brain, Cafeteria, 03 medical and health sciences, 0302 clinical medicine, Fatty acid amide hydrolase, Internal medicine, Threshold of pain, Medicine, Pharmacology (medical), pain, Receptor, media_common, Original Research, Pharmacology, biology, business.industry, animal model, lcsh:RM1-950, Abstinence, biology.organism_classification, animal models, lcsh:Therapeutics. Pharmacology, 030104 developmental biology, Endocrinology, high-fat diet, Opioid, 030220 oncology & carcinogenesis, Cannabinoid, business, medicine.drug
Abstract

There is a strong relationship between palatable diet and pain sensitivity, and the cannabinoid and opioid systems might play an important role in this correlation. The palatable diet used in many animal models of obesity is the cafeteria (CAF) diet, based on human food with high sugar, salt, and fat content. In this study, we investigated whether long-term exposure to a CAF diet could modify pain sensitivity and explored the role of the cannabinergic system in this modification. Male Sprague–Dawley rats were divided into two groups: one fed with standard chow only (CO) and the other with extended access (EA) to a CAF diet. Hot plate and tail flick tests were used to evaluate pain sensitivity. At the end of a 40-day CAF exposure, EA rats showed a significant increase in the pain threshold compared to CO rats, finding probably due to up-regulation of CB1 and mu-opioid receptors. Instead, during abstinence from palatable foods, EA animals showed a significant increase in pain sensibility, which was ameliorated by repeated treatment with a fatty acid amide hydrolase inhibitor, PF-3845 (10 mg/kg, intraperitoneally), every other day for 28 days. Ex vivo analysis of the brains of these rats clearly showed that this effect was mediated by mu-opioid receptors, which were up-regulated following repeated treatment of PF-3845. Our data add to the knowledge about changes in pain perception in obese subjects, revealing a key role of CB1 and mu-opioid receptors and their possible pharmacological crosstalk and reinforcing the need to consider this modulation in planning effective pain management for obese patients.

Published
2020

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