1. Comparative Histopathologic Analysis of Granulomatous Tissue of Endodontic and Periodontal Origin
- Author
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Giampiero Rossi-Fedele, Luigi Canullo, Antonio Scarano, Esma J. Doğramacı, Francesca Camodeca, and Giuseppe Marucchella
- Subjects
business.industry ,Granulation tissue ,Dentistry ,Connective tissue ,030206 dentistry ,General Medicine ,Epithelium ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Periodontal disease ,Statistical significance ,medicine ,Humans ,Tissue type ,Oral Surgery ,business ,Semi quantitative ,Periodontal Diseases - Abstract
PURPOSE The aim of this study was to compare the percentage of tissue types and assess the presence/absence of odontoblasts or preodontoblasts in granulation tissue harvested from lesions associated with teeth extracted due to endodontic and periodontal reasons. MATERIALS AND METHODS Histologic reports of cases with a confirmed diagnosis (ie, endodontic or periodontal diseases) were included. These should include a semiquantitative analysis of the percentage of tissue types per sample (ie, epithelium, subepithelial connective tissue, bone or chronic inflammation/deep connective tissue). The overall percentage of tissue type per diagnosis was calculated. Quantitative variables were summarized with means and standard deviations. Normal distribution was tested by the D'Agostino-Pearson omnibus normality test. The level of P < .05 was adopted for statistical significance. Finally, an analysis of the salient findings was summarized. RESULTS The reports from 19 patients were included, 9 of endodontic and 10 of periodontal origins. The granulomatous tissue of endodontic and periodontal disease origin was similar, and consisted mainly of chronic inflammation (endodontic 40%, periodontal 41.7%), followed by epithelium (endodontic 25.7%, periodontal 29.2%), subepithelial connective tissue (endodontic 18.6%, periodontal 20.8%), and bone (endodontic 15.7%, periodontal 8.3%). No significant differences were found when comparing the groups regarding the percentage of tissue types (P ≥ .05). No osteoblasts or preosteoblasts were reported. CONCLUSION Within the limitations of the study, the granulomatous tissues associated with chronic infection of endodontic or periodontal origin are comparable and consist primarily of chronic inflammatory cells.
- Published
- 2020