231 results on '"Giuseppe Cicero"'
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2. Portal hypertensive enteropathy: multimodality assessment through computed tomography and magnetic resonance enterography
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Giuseppe Cicero, MD, PhD, Francesco Marcello Aricò, MD, Anna Viola, MD, PhD, Velio Ascenti, MD, and Silvio Mazziotti, MD
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Portal hypertensive enteropathy ,Computed Tomography ,Magnetic Resonance Enterography ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Portal hypertension consists in an increased portal vein pressure due to prehepatic, hepatic, or posthepatic conditions, with cirrhosis representing the most common cause. The gastrointestinal tract can be secondarily affected not only with varices formation, whose rupture is one of the most dangerous complications, but also with small and large bowel involvement which can predispose to chronic intestinal bleeding. These conditions respectively take the name of portal hypertensive enteropathy and portal colonopathy and their assessment are of almost exclusive pertinence of endoscopic techniques. Up to now, only few reports have described this condition from the radiological point of view. Nevertheless, imaging modalities are not burdened by the invasiveness of endoscopic procedures and are also capable in providing useful information about the intestinal tract as well as the surrounding tissues. This is the first case reporting a diffuse involvement of the small bowel and the right colon in a patient suffering of portal hypertension due to cirrhosis evaluated through the performance of computed tomography and magnetic resonance enterography.
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- 2022
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3. Unique coexistence of chronic midgut malrotation, mesenteric cyst, and pancreas divisum in a Crohn's disease patient: MR-enterography assessment
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Giuseppe Cicero, MD, PhD and Silvio Mazziotti, MD
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Midgut malrotation ,Mesenteric cyst ,Pancreas divisum ,Crohn's disease ,Magnetic resonance enterography ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Chronic midgut malrotation is a rare condition found in the adult age that predisposes to severe complications. It derives from an incomplete rotation of the mesentery around the superior mesenteric artery during embryogenic development. This results in intestinal loops displacement and mesenteric malfixation. Nevertheless, other congenital abnormalities can be also associated, such as mesenteric cysts and biliopancreatic malformations. Imaging modalities employed in the evaluation of chronic midgut malrotation include contrast radiography, which permits to visualize the localization of the intestinal loops, and ultrasound, that can detect a twist of superior mesenteric vessels. Computed tomography is however considered the modality of choice, owing to its wide field of view and the rapid scan times. The role of magnetic resonance imaging in this field has been barely explored. In particular, magnetic resonance enterography has a consolidated role in the assessment of intestinal loops and allows detecting extra-intestinal findings as well. Moreover, the lack of radiation exposure makes this technique suitable for nonemergency cases, especially in young patients. This is the first description of simultaneous chronic midgut malrotation, mesenteric cyst and pancreas divisum discovered in a Crohn's disease patient. The performance of magnetic resonance enterography allowed to properly interpret this multifaceted clinical picture.
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- 2022
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4. Congenital Infiltrating Lipomatosis of the Face: Multimodality Assessment through CT-Scan and Magnetic Resonance Imaging
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Giuseppe Cicero, Francesco Marcello Arico, and Silvio Mazziotti
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congenital infiltrating lipomatosis of the face ,computed tomography ,magnetic resonance imaging ,Medicine (General) ,R5-920 - Abstract
Congenital infiltrating lipomatosis of the face is a rare and benign condition involving a hamartomatous proliferation of mature adipose cells. The final diagnosis derives from a combination of clinical data, histology, and imaging features and affects the treatment decision. This report describes the clinical case of a young patient suffering from facial lipomatosis with particular emphasis on radiological findings detected at CT-scan and magnetic resonance imaging.
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- 2024
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5. Crohn’s disease at radiological imaging: focus on techniques and intestinal tract
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Giuseppe Cicero and Silvio Mazziotti
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crohn disease ,fluoroscopy ,ultrasound ,computed tomography ,magnetic resonance imaging ,Medicine ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Over recent years, inflammatory bowel diseases have become an issue of increased attention in daily clinical practice, due to both a rising incidence and improved imaging capability in detection. In particular, the diagnosis of Crohn’s disease is based on clinical picture, laboratory tests and colonoscopy with biopsy. However, colonoscopic evaluation is limited to the mucosal layer. Thus, imaging modalities play a pivotal role in enriching the clinical picture, delivering information on intestinal and extraintestinal involvement. All the imaging modalities can be employed in evaluation of Crohn’s disease patients, each of them with specific strengths as well as limitations. In this wide selection, the choice of a proper diagnostic framework can be challenging for the clinician. Therefore, the aim of this work is to offer an overview of the different imaging techniques, with brief technical details and diagnostic potential related to each intestinal tract.
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- 2021
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6. Simultaneous pneumothorax and pneumoperitoneum as a late consequence of traumatic injury of the diaphragm: Multimodality imaging approach with surgical correlation and treatment
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Antonio Solazzo, MD, Mario Barone, MD, Dora Bonanno, MD, Carmelo Sofia, MD, Antonio Bottari, MD, Velio Ascenti, MD, Dario Familiari, MD, Silvio Mazziotti, MD, Giuseppe Cicero, MD, and Francesco Monaco, MD
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Computed Tomography ,Diaphragmatic injury ,Pneumothorax ,Pneumoperitoneum ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Simultaneous occurrence of pneumothorax and pneumoperitoneum is a rare event, usually related to traumas or surgical procedures involving the diaphragm.However, clinicians should be aware of the possible onset of these two clinical conditions even in patients without a recent clinical history that can clearly explain them.Cross-sectional imaging techniques are of great importance, providing crucial information about the patient's clinical status and guiding the following patient management.This work describes a unique case of a sudden occurrence of simultaneous pneumothorax and pneumoperitoneum in a previous asymptomatic man with a solely clinical history of minor trauma during childhood, evaluated through a multimodality imaging approach and treated with video-assisted thoracoscopy surgery.
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- 2021
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7. Virtual non-calcium dual-energy CT: clinical applications
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Tommaso D’Angelo, Moritz H. Albrecht, Danilo Caudo, Silvio Mazziotti, Thomas J. Vogl, Julian L. Wichmann, Simon Martin, Ibrahim Yel, Giorgio Ascenti, Vitali Koch, Giuseppe Cicero, Alfredo Blandino, and Christian Booz
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Algorithms ,Bone marrow ,Calcium ,Edema ,Tomography (x-ray ,computed) ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abstract Dual-energy CT (DECT) has emerged into clinical routine as an imaging technique with unique postprocessing utilities that improve the evaluation of different body areas. The virtual non-calcium (VNCa) reconstruction algorithm has shown beneficial effects on the depiction of bone marrow pathologies such as bone marrow edema. Its main advantage is the ability to substantially increase the image contrast of structures that are usually covered with calcium mineral, such as calcified vessels or bone marrow, and to depict a large number of traumatic, inflammatory, infiltrative, and degenerative disorders affecting either the spine or the appendicular skeleton. Therefore, VNCa imaging represents another step forward for DECT to image conditions and disorders that usually require the use of more expensive and time-consuming techniques such as magnetic resonance imaging, positron emission tomography/CT, or bone scintigraphy. The aim of this review article is to explain the technical background of VNCa imaging, showcase its applicability in the different body regions, and provide an updated outlook on the clinical impact of this technique, which goes beyond the sole improvement in image quality.
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- 2021
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8. High-risk lesions of the breast: concurrent diagnostic tools and management recommendations
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Francesca Catanzariti, Daly Avendano, Giuseppe Cicero, Margarita Garza-Montemayor, Carmelo Sofia, Emmanuele Venanzi Rullo, Giorgio Ascenti, Katja Pinker-Domenig, and Maria Adele Marino
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High-risk lesions ,Ultrasound ,Mammography ,B3 lesions ,Breast imaging ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abstract Breast lesions with uncertain malignant behavior, also known as high-risk or B3 lesions, are composed of a variety of pathologies with differing risks of associated malignancy. While open excision was previously preferred to manage all high-risk lesions, tailored management has been increasingly favored to reduce overtreatment and spare patients from unnecessary anxiety or high healthcare costs associated with surgical excision. The purpose of this work is to provide the reader with an accurate overview focused on the main high-risk lesions of the breast: atypical intraductal epithelial proliferation (atypical ductal hyperplasia), lobular neoplasia (including the subcategories lobular carcinoma in situ and atypical lobular hyperplasia), flat epithelial atypia, radial scar and papillary lesions, and phyllodes tumor. Beyond merely presenting the radiological aspects of these lesions and the recent literature, information about their potential upgrade rates is discussed in order to provide a useful guide for appropriate clinical management while avoiding the risks of unnecessary surgical intervention (overtreatment).
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- 2021
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9. Minimal Fat Content in Papillary Renal Cell Carcinoma Diagnosed with Dual-Layer Dual-Energy CT
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Velio Ascenti, Francesco M. Arico, Renato Trimarchi, Giuseppe Cicero, Antonio Ieni, Marta Rossanese, and Giorgio Ascenti
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papillary renal cell carcinoma ,angiomyolipoma ,dual-energy CT ,spectral CT ,computed tomography ,spiral ,Medicine (General) ,R5-920 - Abstract
A 56-year-old man with a previous right nephrectomy for multiple papillary renal cell carcinomas (pRCC) underwent a follow-up CT scan. Using a dual-layer dual-energy CT (dlDECT), we demonstrated the presence of a small amount of fat in a 2.5 cm pRCC that mimicked the diagnosis of angiomyolipoma (AML). Histological examination demonstrated the absence of macroscopic intratumoral adipose tissue, showing a fair amount of enlarged foam macrophages loaded with intracytoplasmic lipids. The presence of fat density in an RCC is an extremely rare occurrence in the literature. To our knowledge, this is the first description using dlDECT of a minimal amount of fat tissue in a small RCC due to the presence of tumor-associated foam macrophages. Radiologists should be aware of this possibility when characterizing a renal mass with DECT. The option of RCCs must be considered, especially in the case of masses with an aggressive character or a positive history of RCC.
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- 2023
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10. TAS-102 in metastatic colorectal cancer (mCRC): efficacy, tolerability, and quality of life in heavily pretreated elderly patients: a real-life study
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Giuseppe Cicero, Raffaele Addeo, Rossella De Luca, Giuseppe Lo Re, Leonardo Gulotta, Pierenrico Marchesa, and Gaspare Gulotta
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chemotherapy ,elderly patients ,lonsurf ,metastatic colorectal cancer ,quality of life ,tas-102 ,trifluridine/ tipiracil ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Background: TAS-102 is an oral monotherapy, combining trifluridine and tipiracil hydrochloride, indicated for the treatment of pretreated metastatic colorectal cancer (mCRC). The aim of this real-life study is to evaluate the efficacy and safety of TAS-102 in heavily pretreated elderly patients with mCRC whose disease has progressed with standard therapies. Methods: In this retrospective observational study, we enrolled 50 elderly patients >70 years of age (median age 78 years) with a diagnosis of mCRC who were previously treated or were not considered candidates for treatment with other available therapies. Patients aged >70 years with advanced colorectal cancer and with an ECOG performance status of grade 0 (n=18) or grade 1 (n=32) were included. Overall survival and progression-free survival were the primary endpoints, whereas objective response rate, tolerability, and quality of life were the secondary endpoints. Results: Treatment with TAS-102 appeared to be well tolerated and side effects were generally mild, achieving disease control and a benefit on quality of life. The median overall survival was 6.7 (95% CI 5.7–11.3) and the median progression-free survival was 2.1 months (95% CI 1.2–3.2), estimated using the Kaplan– Meier method. Conclusion: TAS-102 represents a manageable and effective therapeutic opportunity and appeared to be well tolerated with generally mild side effects in elderly patients with mCRC who were heavily pretreated with standard therapies.
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- 2020
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11. Pulmonary barotrauma in patient suffering from COVID-19
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Maria Ludovica Carerj, Giuseppe M. Bucolo, Silvio Mazziotti, Alfredo Blandino, Christian Booz, Giuseppe Cicero, and Tommaso D'Angelo
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COVID-19 ,SARS-CoV-2 ,Pandemic ,Pneumomediastinum ,Pneumothorax ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Pneumothorax and pneumomediastinum are life-threatening conditions especially in critically ill patients. One of the most common situations in which they occur is prolonged invasive and non-invasive mechanical ventilation with high end-expiratory pressure. Probably due to the high number of patients with SARS-CoV-2 respiratory infection being treated with mechanical ventilation, increasing number of pulmonary barotrauma cases have been reported.
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- 2022
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12. Diagnosis and Management of Button Battery Ingestion Complicated by Tracheo-Esophageal and Aorto-Esophageal Fistulas
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Ludovica R. M. Lanzafame, Alfredo Blandino, Giuseppe Cicero, Placido Romeo, Salvatore Agati, Rosanna Zanai, Antonio Celona, Christian Booz, Vitali Koch, Silvio Mazziotti, and Tommaso D’Angelo
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foreign bodies ,endoscopy ,computed tomography ,X-ray ,esophageal fistula ,pediatric emergency medicine ,Medicine (General) ,R5-920 - Abstract
Button battery ingestion (BBI) is common in children and its prevalence has increased in the last decades. BBI can be responsible for very severe and potentially fatal complications if not promptly detected. We describe the successful management of two cases of BBI that occurred in two previously healthy infants. Both patients presented with vague symptoms and no witness of foreign body ingestion. The prolonged time of exposure to the corrosive effects of disk batteries was responsible for the development of tracheo-esophageal fistula (TEF) and aorto-esophageal fistula (AEF). We demonstrate how prompt diagnosis and management are crucial for the infants’ survival.
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- 2022
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13. Spontaneous reduction of a minimally complex cyst mimicking a renal cancer
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Giuseppe Cicero, Alfredo Blandino, Fabio Italiano, Martina Francesca Micalizzi, and Silvio Mazziotti
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computed tomography ,magnetic resonance imaging ,renal cyst reduction ,Medicine ,Medicine (General) ,R5-920 - Abstract
Abstract Renal cyst shrinkage is a rare finding. Since the collapsed cystic walls may mimic soft tissue components, this scenario has to be taken into account in the differential diagnosis of benign and malignant renal cysts.
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- 2019
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14. Lipomatosis of the ileocecal valve: A not to miss diagnosis when performing magnetic resonance enterography
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Giuseppe Cicero, Socrate Pallio, Tommaso D’Angelo, and Silvio Mazziotti
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ileocecal valve ,lipomatosis ,magnetic resonance enterography ,Medicine ,Medicine (General) ,R5-920 - Abstract
Abstract Lipomatosis of ileocecal valve is a rare condition that can be missed using the standard protocol of Magnetic Resonance Enterography. Additional T1‐weighted scans without fat saturation can be helpful when adipose lesions of the bowel are suspected.
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- 2021
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15. Magnetic resonance enterography appraisal of lupus enteritis: A case report
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Giuseppe Cicero, MD, Alfredo Blandino, MD, Tommaso D'Angelo, MD, Antonio Bottari, MD, Marco Cavallaro, MD, Giorgio Ascenti, MD, and Silvio Mazziotti, MD
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Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a multisystemic involvement. Usually, radiological imaging does not play a central role in evaluating SLE patients, although it may be helpful in assessing complications, allowing a more accurate evaluation of the patient. Lupus enteritis is one of the most common and potentially lethal manifestations of the gastrointestinal involvement of SLE. Among the imaging modalities, computed tomography scan is now considered the gold standard in evaluating lupus enteritis, although it is impaired by the radiation exposure. On the other hand, during the last decade magnetic resonance enterography has achieved a remarkable importance in evaluating small bowel lesions in patients affected by Crohn's disease. We describe the first case report of lupus enteritis evaluated with magnetic resonance enterography, putting forward the proposal of a reliable and radiation-free alternative to computed tomography scan in evaluating the intestinal involvement of SLE. Keywords: Magnetic resonance enterography, Lupus enteritis
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- 2018
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16. Stroke and Systemic Lupus Erythematosus: A Review
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Marco Cavallaro, Ugo Barbaro, Antonio Caragliano, Marcello Longo, Giuseppe Cicero, Francesca Granata, and Sergio Racchiusa
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Endothelium ,inflammation ,intracerebral haemorrhage (IH) ,stroke ,subarachnoid haemorrhage (SAH) ,systemic lupus erythematosus (SLE) ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease that involves collagen tissue throughout the body. Several previous studies have shown that the risk of ischaemic and haemorrhagic stroke is significantly higher in SLE when compared to the general population, particularly in young individuals, representing one of the principal causes of death in these patients. Though the precise pathophysiology behind this increased risk is still poorly understood, several mechanisms are suggested to play a role. The high burden of cerebral small vessel disease features noted on brain neuroimaging studies, as well as the accelerated process of atherosclerosis identified in these patients, are likely to be responsible for at least some of the ischaemic strokes occurring in the SLE population. Repeated episodes of arterial and venous thrombosis secondary to antiphospholipid syndrome are likewise important. Less is known regarding the exact pathophysiological relationship between SLE and the high incidence of haemorrhagic stroke, though thrombocytopenia and a greater susceptibility to form typical and atypical brain aneurysms, which may then rupture, are thought to be the main mechanisms responsible for the occurrence of intracerebral and subarachnoid haemorrhage, respectively. Both inflammatory and noninflammatory events, all involving the immune system, are responsible for several pathological changes affecting cerebral vessels of every calibre in SLE, as confirmed by histopathology. In this context, endothelial activation and dysfunction play a critical role. This review will briefly analyse the most important factors responsible for the higher ischaemic and haemorrhagic stroke risk in the SLE population, with a particular focus on brain vascular changes.
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- 2018
17. Clinical and biochemical markers of visceral adipose tissue activity: Body mass index, visceral adiposity index, leptin, adiponectin, and matrix metalloproteinase-3. Correlation with Gleason patterns 4 and 5 at prostate biopsy
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Vincenzo Serretta, Alberto Abrate, Simone Siracusano, Cristina Scalici Gesolfo, Marco Vella, Fabrizio Di Maida, Antonina Cangemi, Giuseppe Cicero, Elisabetta Barresi, and Chiara Sanfilippo
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Adiponectin ,body mass index ,Gleason pattern ,leptin ,matrix metalloproteinase-3 ,obesity ,prostate cancer ,visceral adiposity index ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Context: The correlation between aggressive prostate cancer and obesity mainly based on body mass index (BMI) and pathology after surgery remains controversial. Aims: The aim of the study was to correlate BMI, visceral adiposity index (VAI), and the plasmatic levels of leptin, adiponectin, and matrix metalloproteinase-3 (MMP-3), and biomarkers of adipose tissue function, with the detection of Gleason patterns 4 and 5 at biopsy. Subjects and Methods: Consecutive patients with prostate cancer at 12-core transrectal biopsy were enrolled. BMI, waist circumference (WC), blood samples to evaluate the plasmatic levels of triglycerides (TG) and high-density lipoproteins (HDL), adiponectin, leptin, and MMP-3 were obtained immediately before biopsy. The VAI was calculated according to the formula: WC/(39.68 + [1.88 × BMI]) × TG/1.03 × 1.31/HDL. Results: One hundred and forty-nine patients were entered. The median PSA, BMI, and VAI were 10.0 ng/ml, 27.6 kg/m2, and 4.6, respectively. Gleason patterns 4 or 5 were detected in 68 (45.6%) patients; in 15 (41.7%), 31 (44.9%), and 22 (50.0%) among normal weight, overweight, and obese patients, respectively (P = 0.55). The statistical analysis did not show any significant correlation between BMI, VAI, the plasmatic levels of leptin, adiponectin, MMP-3, and the detection of Gleason patterns 4 and 5 at biopsy. A statistically significant association emerged with older age (P = 0.017) and higher PSA values (P = 0.02). Conclusion: We did not find any association between BMI, VAI, the plasmatic levels of adiponectin, leptin, and MMP-3 and the detection of Gleason patterns 4 and 5 at prostate biopsy.
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- 2018
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18. Prognostic Relevance of Neutrophil to Lymphocyte Ratio (NLR) in Luminal Breast Cancer: A Retrospective Analysis in the Neoadjuvant Setting
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Antonino Grassadonia, Vincenzo Graziano, Laura Iezzi, Patrizia Vici, Maddalena Barba, Laura Pizzuti, Giuseppe Cicero, Eriseld Krasniqi, Marco Mazzotta, Daniele Marinelli, Antonella Amodio, Clara Natoli, and Nicola Tinari
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luminal breast cancer ,neoadjuvant chemotherapy ,neutrophil to lymphocyte ratio (NLR) ,predictive/prognostic biomarkers ,Cytology ,QH573-671 - Abstract
The neutrophil to lymphocyte ratio (NLR) is a promising predictive and prognostic factor in breast cancer. We investigated its ability to predict disease-free survival (DFS) and overall survival (OS) in patients with luminal A- or luminal B-HER2-negative breast cancer who received neoadjuvant chemotherapy (NACT). Pre-treatment complete blood cell counts from 168 consecutive patients with luminal breast cancer were evaluated to assess NLR. The study population was stratified into NLRlow or NLRhigh according to a cut-off value established by receiving operator curve (ROC) analysis. Data on additional pre- and post-treatment clinical-pathological characteristics were also collected. Kaplan–Meier curves, log-rank tests, and Cox proportional hazards models were used for statistical analyses. Patients with pre-treatment NLRlow showed a significantly shorter DFS (HR: 6.97, 95% CI: 1.65–10.55, p = 0.002) and OS (HR: 7.79, 95% CI: 1.25–15.07, p = 0.021) compared to those with NLRhigh. Non-ductal histology, luminal B subtype, and post-treatment Ki67 ≥ 14% were also associated with worse DFS (p = 0.016, p = 0.002, and p = 0.001, respectively). In a multivariate analysis, luminal B subtype, post-treatment Ki67 ≥ 14%, and NLRlow remained independent prognostic factors for DFS, while only post-treatment Ki67 ≥ 14% and NLRlow affected OS. The present study provides evidence that pre-treatment NLRlow helps identify women at higher risk of recurrence and death among patients affected by luminal breast cancer treated with NACT.
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- 2021
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19. Monodisperse magnetite nanoparticles with high sensitivity as MRI contrast agents
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Ernesto Amato, Paola Lanzafame, Antonio Italiano, Giuseppe Cicero, Georgia Papanikolaou, Siglinda Perathoner, Gabriele Centi, and Fabio Minutoli
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Science (General) ,Q1-390 - Abstract
The preparation of monodisperse and biocompatible water-soluble super-paramagnetic iron oxide nanoparticles (SPIONs) with high sensitivity in Magnetic Resonance Imaging (MRI) represents a challenge for the development of contrast agents. Here we report the synthesis of highly monodisperse citric acid (CA) coated SPIONs with an average diameter of 9 nm and spherical shape, prepared through a suitably optimized coprecipitation method. CA-SPIONs show a high solubility and stability in aqueous medium. Imaging of CA-SPIONs aqueous suspensions was performed in a clinical 1.5-T MRI scanner and different clinical acquisition sequences were exploited. Results show that image contrast can be effectively improved when concentrations of SPIONs lower than 1 ppm are present, and that the echo time is the main parameter influencing the image contrast of SPION-loaded solutions. Moreover, we found that CA-SPIONs show a high value of transverse relaxivity of 128 L mmol^(-1) s^(-1) (higher than the commercial contrast agents). Our results are encouraging for the further development of clinical application of SPIONs in MRI, and can represent a starting point for the optimization of clinical imaging exploiting the contrast enhancement of such agents. Namely, it seems possible to achieve an optimal image contrast with low concentration of SPIONs; this could lead to a lower probability of side effects.
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- 2018
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20. Recurrent acute pancreatitis caused by duodenal duplication cyst in a young patient
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Giuseppe Cicero, Francesca Catanzariti, Ugo Barbaro, Velio Ascenti, and Silvio Mazziotti
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duodenum ,duplication cyst ,magnetic resonance cholangiopancreatography ,magnetic resonance imaging ,Medicine ,Medicine (General) ,R5-920 - Abstract
Abstract Duodenal duplication cyst is a rare congenital anomaly that develops during the embryonic stage and could remain unknown until the adult age. Although often asymptomatic, duodenal duplication cysts can lead to various clinical scenarios with different degree of severity, from nonspecific abdominal pain up to cholestasis, intussusception or pancreatitis.
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- 2019
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21. Intravesical chemotherapy for intermediate risk non-muscle invasive bladder cancer recurring after a first cycle of intravesical adjuvant therapy
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Vincenzo Serretta, Francesco Sommatino, Cristina Scalici Gesolfo, Vito Franco, Giuseppe Cicero, and Rosalinda Allegro
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Bacillus Calmette-Guerin ,intermediate risk ,intravesical chemotherapy ,non muscle invasive bladder cancer ,recurrence ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Context: The therapeutic strategy in intermediate risk (IR) non-muscle invasive bladder cancer (NMIBC) recurring after intravesical therapy (IT) is not well defined. Most patients are usually retreated by Bacillus Calmette-Guerin (BCG). Aims: To evaluate the efficacy of intravesical chemotherapy (ICH) given at recurrence after the first cycle of ICH in IR-NMIBC recurring 6 months or later. Settings and Design: Retrospective analysis of the efficacy of ICH given after previous IT. Materials and Methods: The clinical files of IR-NMIBC patients recurring later than 6 months after transurethral resection (TUR) and IT and retreated by IT were reviewed. The patients should be at intermediate risk both initially and at the first recurrence. BCG should have been given at full dose. Cytology and cystoscopy were performed 3 monthly for 2 years and then 6 monthly. Statistical Analysis: The RFS was estimated by the Kaplan-Meier method and the differences between treatment groups were compared by log-rank test. Mann Whitney U-test was used to compare the parameters′ distribution for median time to recurrence. Multivariate Cox proportional hazards models were used. Results: The study included 179 patients. The first IT was ICH in 146 (81.6%) and BCG in 33 (18.4%), re-IT was ICH in 112 (62.6%) and BCG in 67 (37.4%) patients. Median time to recurrence was 18 and 16 months after first and second IT (P = 0.32). At 3 years, 24 (35.8%) and 49 (43.8%) patients recurred after BCG and ICH, respectively (P = 0.90). No difference in RFS was found between BCG and ICH given after a first cycle of ICH (P = 0.23). Conclusions: Re-treatment with ICH could represent a legitimate option to BCG in patients harboring IR-NMIBC recurring after TUR and previous ICH. Prospective trials are needed.
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- 2015
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22. Magnetic Resonance Enterography Findings of Intestinal Behçet Disease in a Child
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Tommaso D’Angelo, Romina Gallizzi, Claudio Romano, Giuseppe Cicero, and Silvio Mazziotti
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Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Behçet’s disease (BD) is a multisystem disorder of unknown aetiology, characterized by recurrent oral ulcers, genital ulcers, uveitis, skin lesions, and pathergy. Gastrointestinal disease outside the oral cavity is well recognized and usually takes the form of small intestinal ulcers, with the most significant lesions frequently occurring in the ileocaecal region. Symptoms usually include nausea, vomiting, colicky abdominal pain, and change in bowel habit and it is not unusual that patients may present late, with life-threatening complications requiring surgery. Diagnosis has been hindered for many years by limitations in imaging the small bowel and it is usually achieved by means of endoscopy and CT of the abdomen. Magnetic resonance enterography (MRE) is a relatively new technique, which has a high diagnostic rate in patients with Crohn’s disease (CD). Although many similarities between CD and intestinal BD have already been described in literature, the role of MRE in the evaluation of intestinal BD has never been defined up to now. We report a case of a 12-year-old female patient with diagnosis of BD who presented at our institution for recurrent colicky abdominal pain and diarrhoea. The patient underwent MRE that demonstrated the gastrointestinal involvement.
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- 2017
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23. Superinfection of a Dead Hepatic Echinococcal Cyst with a Cutaneous Fistulization
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Giuseppe Cicero, Alfredo Blandino, Giorgio Ascenti, Tommaso D’Angelo, Luciano Frosina, Carmela Visalli, Ignazio Salamone, Maria Adele Marino, Marco Cavallaro, and Silvio Mazziotti
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Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Cystic echinococcosis (CE), also known as “hydatid disease” (HD), is a zoonotic infection caused by the larval stage of Echinococcus granulosus, which infects humans as intermediate hosts through the orofecal route. Carried by the intestinal venous blood, the embryos released by the eggs of the tapeworms can reach every organ, especially the liver, turning into a hydatid cyst. Usually asymptomatic, the cysts can be incidentally detected through radiological examinations performed for other reasons. We show an unusual case of superinfection of a hydatid cyst with typical radiological features of inactivity (WHO-type CE5) with an even rarer skin fistulization passing through a subcutaneous-abdominal abscess involving the right iliac muscle.
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- 2017
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24. Primary Non-Hodgkins lymphoma of the parotid gland Linfomas malignos primários nas glandulas salivares
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Francesco Dispenza, Giuseppe Cicero, Gianluca Mortellaro, Donatella Marchese, Gautham Kulamarva, and Carlo Dispenza
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glândulas salivares ,linfoma ,linfoma não hodgkin ,neoplasias parotídeas ,radioterapia ,lymphoma ,non-hodgkin ,parotid neoplasms ,radiotherapy ,salivary glands ,Otorhinolaryngology ,RF1-547 - Abstract
Primary malignant lymphomas in the salivary glands are relatively rare. Clinical presentation is not characteristic and the disease is often overlooked resulting in diagnosis and treatment delays. AIM: To stress the importance of the diagnostic process and combined management, we present a series of eight patients with malignant lymphoma of the parotid who were diagnosed only after surgery and managed with radiation and chemotherapy. METHODS: Retrospective series of patients with primary malignant lymphoma of the parotid gland managed with radiotherapy and diagnostic surgical partial resection. RESULTS: After treatment completion we achieved a loco-regional control rate of 87.5%. Toxicity was charted according to the Common Toxicity Criteria and it was seen in six patients (75%). Six patients are still alive without evidence of recurrent disease in their last follow-up. CONCLUSION: Our study confirms that primary early stage Non-Hodgkin Lymphoma of the parotid gland is a disease with an excellent prognosis and a good local control rate, with minimal morbidity.Linfomas primários das glândulas salivares são relativamente raros. Sua apresentação clínica não écaracterística e, frequentemente, a doença passa despercebida, resultando em atrasos no diagnóstico e tratamento. OBJETIVO: Enfatizar a importância do diagnóstico e tratamento combinado. Apresentamos uma casuística de oito pacientes com linfoma maligno da parótida, que foram diagnosticados somente após a cirurgia e tratados com radio e quimioterapia. MÉTODOS: Estudo retrospectivo de pacientes com linfoma maligno primário da glândula parótida, tratados com radioterapia e ressecção cirúrgica parcial diagnóstica. RESULTADOS: Após a conclusão do tratamento, atingimos uma taxa de controle loco-regional de 87,5%. A toxicidade foi classificada de acordo com os Critérios Comuns de Toxicidade e afetou seis pacientes (75%). Seis pacientes ainda estão vivos, sem evidência de doença na mais recente consulta de acompanhamento. CONCLUSÃO: Nosso estudo confirma que o Linfoma primário Não-Hodgkin em estágios iniciais da glândula parótida é uma doença com excelente prognóstico e boa taxa de controle local, com mínima morbidade.
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- 2011
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25. Stabilizing versus Destabilizing the Microtubules: A Double-Edge Sword for an Effective Cancer Treatment Option?
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Daniele Fanale, Giuseppe Bronte, Francesco Passiglia, Valentina Calò, Marta Castiglia, Florinda Di Piazza, Nadia Barraco, Antonina Cangemi, Maria Teresa Catarella, Lavinia Insalaco, Angela Listì, Rossella Maragliano, Daniela Massihnia, Alessandro Perez, Francesca Toia, Giuseppe Cicero, and Viviana Bazan
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 ,Cytology ,QH573-671 - Abstract
Microtubules are dynamic and structural cellular components involved in several cell functions, including cell shape, motility, and intracellular trafficking. In proliferating cells, they are essential components in the division process through the formation of the mitotic spindle. As a result of these functions, tubulin and microtubules are targets for anticancer agents. Microtubule-targeting agents can be divided into two groups: microtubule-stabilizing, and microtubule-destabilizing agents. The former bind to the tubulin polymer and stabilize microtubules, while the latter bind to the tubulin dimers and destabilize microtubules. Alteration of tubulin-microtubule equilibrium determines the disruption of the mitotic spindle, halting the cell cycle at the metaphase-anaphase transition and, eventually, resulting in cell death. Clinical application of earlier microtubule inhibitors, however, unfortunately showed several limits, such as neurological and bone marrow toxicity and the emergence of drug-resistant tumor cells. Here we review several natural and synthetic microtubule-targeting agents, which showed antitumor activity and increased efficacy in comparison to traditional drugs in various preclinical and clinical studies. Cryptophycins, combretastatins, ombrabulin, soblidotin, D-24851, epothilones and discodermolide were used in clinical trials. Some of them showed antiangiogenic and antivascular activity and others showed the ability to overcome multidrug resistance, supporting their possible use in chemotherapy.
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- 2015
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26. Chemotherapy sensitizes colon cancer initiating cells to Vγ9Vδ2 T cell-mediated cytotoxicity.
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Matilde Todaro, Valentina Orlando, Giuseppe Cicero, Nadia Caccamo, Serena Meraviglia, Giorgio Stassi, and Francesco Dieli
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Medicine ,Science - Abstract
Colon cancer comprises a small population of cancer initiating stem cells (CIC) that is responsible for tumor maintenance and resistance to anti-cancer therapies, possibly allowing for tumor recapitulation once treatment stops. Combinations of immune-based therapies with chemotherapy and other anti-tumor agents may be of significant clinical benefit in the treatment of colon cancer. However, cellular immune-based therapies have not been experimented yet in the population of colon CICs. Here, we demonstrate that treatment with low concentrations of commonly used chemotherapeutic agents, 5-fluorouracyl and doxorubicin, sensitize colon CICs to Vγ9Vδ2 T cell cytotoxicity. Vγ9Vδ2 T cell cytotoxicity was largely mediated by TRAIL interaction with DR5, following NKG2D-dependent recognition of colon CIC targets. We conclude that in vivo activation of Vγ9Vδ2 T cells or adoptive administration of ex-vivo expanded Vγ9Vδ2 T cells at suitable intervals after chemotherapy may substantially increase anti-tumor activities and represent a novel strategy for colon cancer immunotherapy.
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- 2013
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27. Characterization of human γδ T lymphocytes infiltrating primary malignant melanomas.
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Adriana Cordova, Francesca Toia, Carmela La Mendola, Valentina Orlando, Serena Meraviglia, Gaetana Rinaldi, Matilde Todaro, Giuseppe Cicero, Leonardo Zichichi, Paolo Li Donni, Nadia Caccamo, Giorgio Stassi, Francesco Dieli, and Francesco Moschella
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Medicine ,Science - Abstract
T lymphocytes are often induced naturally in melanoma patients and infiltrate tumors. Given that γδ T cells mediate antigen-specific killing of tumor cells, we studied the representation and the in vitro cytokine production and cytotoxic activity of tumor infiltrating γδ T cells from 74 patients with primary melanoma. We found that γδ T cells represent the major lymphocyte population infiltrating melanoma, and both Vδ1(+) and Vδ2(+) cells are involved. The majority of melanoma-infiltrating γδ cells showed effector memory and terminally-differentiated phenotypes and, accordingly, polyclonal γδ T cell lines obtained from tumor-infiltrating immune cells produced IFN-γ and TNF-α and were capable of killing melanoma cell lines in vitro. The cytotoxic capability of Vδ2 cell lines was further improved by pre-treatment of tumor target cells with zoledronate. Moreover, higher rate of γδ T cells isolation and percentages of Vδ2 cells correlate with early stage of development of melanoma and absence of metastasis. Altogether, our results suggest that a natural immune response mediated by γδ T lymphocytes may contribute to the immunosurveillance of melanoma.
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- 2012
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28. Vγ9Vδ2 T cells as a promising innovative tool for immunotherapy of hematologic malignancies
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Serena Meraviglia, Carmela La Mendola, Valentina Orlando, Francesco Scarpa, Giuseppe Cicero, and Francesco Dieli
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Vc9Vd2 T cells - Hematologic malignancies - Immunotherapy - Cytokines - CytotoxicityVc9Vd2 T cells - Hematologic malignancies - Immunotherapy - Cytokines - Cytotoxicity ,Other systems of medicine ,RZ201-999 ,Internal medicine ,RC31-1245 - Abstract
The potent anti-tumor activities of γδ T cells, their ability to produce pro-inflammatory cytokines, and their strong cytolytic activity have prompted the development of protocols in which γδ agonists or ex vivo-expanded γδ cells are administered to tumor patients. γδ T cells can be selectively activated by either synthetic phosphoantigens or by drugs that enhance their accumulation into stressed cells as aminobisphosphonates, thus offering new avenues for the development of γδ T cell-based immunotherapies. The recent development of small drugs selectively activating Vγ9Vδ2 T lymphocytes, which upregulate the endogenous phosphoantigens, has enabled the investigators to design the experimental approaches of cancer immunotherapies; several ongoing phase I and II clinical trials are focused on the role of the direct bioactivity of drugs and of adoptive cell therapies involving phosphoantigen- or aminobisphosphonate-activated Vγ9Vδ2 T lymphocytes in humans. In this review, we focus on the recent advances in the activation/expansion of γδ T cells in vitro and in vivo that may represent a promising target for the design of novel and highly innovative immunotherapy in patients with hematologic malignancies.
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- 2011
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29. Global Burden of Cardiovascular Diseases and Risks, 1990-2022
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Mensah, George A., primary, Fuster, Valentin, additional, Murray, Christopher J.L., additional, Roth, Gregory A., additional, Mensah, George A., additional, Abate, Yohannes Habtegiorgis, additional, Abbasian, Mohammadreza, additional, Abd-Allah, Foad, additional, Abdollahi, Ashkan, additional, Abdollahi, Mohammad, additional, Abdulah, Deldar Morad, additional, Abdullahi, Auwal, additional, Abebe, Ayele Mamo, additional, Abedi, Aidin, additional, Abedi, Armita, additional, Abiodun, Olugbenga Olusola, additional, Ali, Hiwa Abubaker, additional, Abu-Gharbieh, Eman, additional, Abu-Rmeileh, Niveen M.E., additional, Aburuz, Salahdein, additional, Abushouk, Abdelrahman I., additional, Abu-Zaid, Ahmed, additional, Adane, Tigist Demssew, additional, Adderley, Nicola J., additional, Adebayo, Oladimeji M., additional, Aden, Bashir, additional, Adeyeoluwa, Temitayo Esther, additional, Adeyomoye, Olorunsola Israel, additional, Sakilah Adnani, Qorinah Estiningtyas, additional, Afrashteh, Fatemeh, additional, Afyouni, Shadi, additional, Afzal, Saira, additional, Agasthi, Pradyumna, additional, Agodi, Antonella, additional, Aguilera Arriagada, Constanza Elizabeth, additional, Agyemang-Duah, Williams, additional, Ahinkorah, Bright Opoku, additional, Ahmad, Aqeel, additional, Ahmad, Danish, additional, Ahmad, Firdos, additional, Ahmad, Muayyad M., additional, Ahmed, Ayman, additional, Ahmed, Haroon, additional, Ahmed, Muktar Beshir, additional, Ahmed, Syed Anees, additional, Ajami, Marjan, additional, Akinosoglou, Karolina, additional, Ala, Moein, additional, Ali AL-Ahdal, Tareq Mohammed, additional, Alalalmeh, Samer O., additional, Al-Aly, Ziyad, additional, Alam, Nazmul, additional, Al-amer, Rasmieh Mustafa, additional, Alashi, Alaa, additional, Albashtawy, Mohammed, additional, AlBataineh, Mohammad T., additional, Alema, Haileselasie Berhane, additional, Alemi, Sharifullah, additional, Alemu, Yihun Mulugeta, additional, Saeed Al-Gheethi, Adel Ali, additional, Alhabib, Khalid F., additional, Naji Alhalaiqa, Fadwa Alhalaiqa, additional, Ali, Mohammed Usman, additional, Ali, Rafat, additional, pursuing, PhD., additional, Shujait Ali, Syed Shujait, additional, Alicandro, Gianfranco, additional, Alikhani, Reyhaneh, additional, Aljunid, Syed Mohamed, additional, Alla, François, additional, Almahmeed, Wael, additional, Al-Marwani, Sabah, additional, Alonso, Jordi, additional, Al-Raddadi, Rajaa M., additional, Alvi, Farrukh Jawad, additional, Alvis-Guzman, Nelson, additional, Alvis-Zakzuk, Nelson J., additional, Alwafi, Hassan, additional, Aly, Hany, additional, Amegbor, Prince M., additional, Amin, Tarek Tawfik, additional, Amindarolzarbi, Alireza, additional, Amini-Rarani, Mostafa, additional, Amiri, Sohrab, additional, Ammirati, Enrico, additional, Anand, Tanu, additional, Ancuceanu, Robert, additional, Anderlini, Deanna, additional, Anil, Abhishek, additional, Ansari, Golnoosh, additional, Anyanwu, Philip Emeka, additional, Anyasodor, Anayochukwu Edward, additional, Carace Apostol, Geminn Louis, additional, Arabloo, Jalal, additional, Arafat, Mosab, additional, Aravkin, Aleksandr Y., additional, Aremu, Olatunde, additional, Armocida, Benedetta, additional, Ärnlöv, Johan, additional, Arowosegbe, Oluwaseyi Olalekan, additional, Artamonov, Anton A., additional, Artanti, Kurnia Dwi, additional, Arulappan, Judie, additional, Aruleba, Idowu Thomas, additional, Arumugam, Ashokan, additional, Aryan, Zahra, additional, Asghari-Jafarabadi, Mohammad, additional, Astell-Burt, Thomas, additional, Ataei, Mahshid, additional, Athar, Mohammad, additional, Atreya, Alok, additional, Aujayeb, Avinash, additional, Awotidebe, Adedapo Wasiu, additional, Aynalem, Amdehiwot A., additional, Azizi, Zahra, additional, Azzam, Ahmed Y., additional, Babu, Abraham Samuel, additional, Badar, Muhammad, additional, Bader, Feras, additional, Badiye, Ashish D., additional, Bagga, Arvind, additional, Bagherieh, Sara, additional, Asl, Farshad Bahrami, additional, Bai, Ruhai, additional, Baker, Jennifer L., additional, Bakkannavar, Shankar M., additional, Bako, Abdulaziz T., additional, Bakshi, Ravleen Kaur, additional, Balogun, Saliu A., additional, Baltatu, Ovidiu Constantin, additional, Bam, Kiran, additional, Banach, Maciej, additional, Bandyopadhyay, Soham, additional, Banik, Biswajit, additional, Chandra Banik, Palash, additional, Bansal, Kannu, additional, Baradaran, Hamid Reza, additional, Barbic, Franca, additional, Barchitta, Martina, additional, Bardhan, Mainak, additional, Barker-Collo, Suzanne Lyn, additional, Bärnighausen, Till Winfried, additional, Barone-Adesi, Francesco, additional, Barteit, Sandra, additional, Barua, Lingkan, additional, Bashiri, Azadeh, additional, Bayati, Mohsen, additional, Bayileyegn, Nebiyou Simegnew, additional, Behboudi, Emad, additional, Behnoush, Amir Hossein, additional, Béjot, Yannick, additional, Belay, Sefealem Assefa, additional, Belete, Melaku Ashagrie, additional, Belgaumi, Uzma Iqbal, additional, Bell, Michelle L., additional, Belo, Luis, additional, Bendak, Salaheddine, additional, Benfor, Bright, additional, Bennett, Derrick A., additional, Bensenor, Isabela M., additional, Benziger, Catherine P., additional, Beran, Azizullah, additional, Berman, Adam E., additional, Bermudez, Amiel Nazer C., additional, Bertolacci, Gregory J., additional, Beyene, Habtamu B., additional, Beyene, Kebede A., additional, Srikanth Bhagavathula, Akshaya Srikanth, additional, Bhardwaj, Nikha, additional, Bhardwaj, Pankaj, additional, Bhardwaj, Prarthna V., additional, Bhat, Vivek, additional, Bhatti, Gurjit Kaur, additional, Bhatti, Jasvinder Singh, additional, Bikbov, Boris, additional, Bikov, Andras, additional, Birck, Marina G., additional, Biswas, Bijit, additional, Bitaraf, Saeid, additional, Bodunrin, Aadam Olalekan, additional, Bogale, Eyob Ketema, additional, Bogale, Kassawmar Angaw, additional, Boloor, Archith, additional, Hashemi, Milad Bonakdar, additional, Borhany, Hamed, additional, Boyko, Edward J., additional, Braithwaite, Dejana, additional, Brant, Luisa C., additional, Brauer, Michael, additional, Breitner, Susanne, additional, Briko, Andrey, additional, Bulto, Lemma N., additional, Bustanji, Yasser, additional, Butt, Zahid A., additional, Calina, Daniela, additional, Cao, Fan, additional, Cárdenas, Rosario, additional, Carr, Sinclair, additional, Carreras, Giulia, additional, Carrero, Juan J., additional, Carvalho, Márcia, additional, Castaldelli-Maia, Joao Mauricio, additional, Castañeda-Orjuela, Carlos A., additional, Cattaruzza Luca Cegolon, Maria Sofia, additional, Cerin, Ester, additional, Chahine, Yaacoub, additional, Kai Chan, Jeffrey Shi, additional, Chan, Mei Yen, additional, Chan, Raymond N.C., additional, Charalampous, Periklis, additional, Charan, Jaykaran, additional, Chattu, Vijay Kumar, additional, Chen, An-Tian, additional, Chen, Catherine S., additional, Chen, Haowei, additional, Chennapragada, Suma Sri, additional, Chew, Derek S., additional, Chi, Gerald, additional, Ching, Patrick R., additional, Chitheer, Abdulaal, additional, Jemma Cho, So Mi, additional, Cho, William C.S., additional, Chong, Bryan, additional, Chopra, Hitesh, additional, Choudhary, Rahul, additional, Chowdhury, Enayet Karim, additional, Chowdhury, Rajiv, additional, Chu, Dinh-Toi, additional, Chukwu, Isaac Sunday, additional, Giuseppe Cicero, Arrigo Francesco, additional, Cindi, Zinhle, additional, Cioffi, Iolanda, additional, Coberly, Kaleb, additional, Coffey, Sean, additional, Columbus, Alyssa, additional, Conde, Joao, additional, Conti, Sara, additional, Corso, Barbara, additional, Cortés, Sandra, additional, Cortesi, Paolo Angelo, additional, Costa, Vera Marisa, additional, Couto, Rosa A.S., additional, Cowart, Emma Johnson, additional, Criqui, Michael H., additional, Cruz, Jessica A., additional, Dadana, Sriharsha, additional, Dadras, Omid, additional, Dai, Xiaochen, additional, Dai, Zhaoli, additional, Dalaba, Maxwell Ayindenaba, additional, Moura Damasceno, Albertino Antonio, additional, Damiani, Giovanni, additional, D'Amico, Emanuele, additional, Das, Saswati, additional, Das, Subasish, additional, Dashti, Mohsen, additional, Dashtkoohi, Mohammad, additional, Dastmardi, Maedeh, additional, Davletov, Kairat, additional, Debele, Aklilu Tamire, additional, Debopadhaya, Shayom, additional, DeCleene, Nicole K., additional, Delgado-Enciso, Ivan, additional, Delgado-Saborit, Juana Maria, additional, Demessa, Berecha Hundessa, additional, Demetriades, Andreas K., additional, Deng, Xinlei, additional, Denova-Gutiérrez, Edgar, additional, Dereje, Nebiyu Dereje, additional, Asrat Derese, Awoke Masrie, additional, Desai, Hardik Dineshbhai, additional, Desai, Rupak, additional, Chellaiyan Devanbu, Vinoth Gnana, additional, Rahman Dewan, Syed Masudur, additional, Dey, Sourav, additional, Dhulipala, Vishal R., additional, Diaz, Daniel, additional, Diaz, Michael J., additional, Ding, Delaney D., additional, Dinis-Oliveira, Ricardo Jorge, additional, Do, Thanh Chi, additional, Phuong Do, Thao Huynh, additional, Doaei, Saeid, additional, Dohare, Sushil, additional, Dong, Wanyue, additional, D'Oria, Mario, additional, Mombaque dos Santos, Wendel, additional, Douiri, Abdel, additional, Dowou, Robert Kokou, additional, Dsouza, Ashel Chelsea, additional, Dsouza, Haneil Larson, additional, Dsouza, Viola, additional, Du, Mi, additional, Duraes, Andre Rodrigues, additional, Durojaiye, Oyewole Christopher, additional, Dutta, Sulagna, additional, Dziedzic, Arkadiusz Marian, additional, Ebrahimi, Alireza, additional, Efendi, Defi, additional, Efendi, Ferry, additional, Effendi, Diyan Ermawan, additional, Eini, Ebrahim, additional, Ekholuenetale, Michael, additional, Ekundayo, Temitope Cyrus, additional, El Sayed, Iman, additional, El Tantawi, Maha, additional, Elbarazi, Iffat, additional, Elgar, Frank J., additional, Elgendy, Islam Y., additional, Elhadi, Muhammed, additional, El-Huneidi, Waseem, additional, Emamverdi, Mehdi, additional, Emeto, Theophilus I., additional, Erkhembayar, Ryenchindorj, additional, Eshetie, Tesfahun C., additional, Espinosa-Montero, Juan, additional, Etaee, Farshid, additional, Fabin, Natalia, additional, Fadhil, Ibtihal, additional, Fagbamigbe, Adeniyi Francis, additional, Falzone, Luca, additional, Sofia e Sá Farinha, Carla, additional, Faris, MoezAlIslam Ezzat Mahmoud, additional, Faro, Andre, additional, Faruque, Mithila, additional, Farwati, Medhat, additional, Fasanmi, Abidemi Omolara, additional, Fatehizadeh, Ali, additional, Fazeli, Pooria, additional, Feigin, Valery L., additional, Feng, Xiaoqi, additional, Fereshtehnejad, Seyed-Mohammad, additional, Feroze, Abdullah Hamid, additional, Ferrara, Pietro, additional, Ferreira, Nuno, additional, Filip, Irina, additional, Fleszar, Laura, additional, Flood, David, additional, Folayan, Morenike Oluwatoyin, additional, Fomenkov, Artem Alekseevich, additional, Fonseca, Diogo A., additional, Fornari, Carla, additional, Foschi, Matteo, additional, Franklin, Richard Charles, additional, Fukumoto, Takeshi, additional, BlimaFux, PhD., additional, Gaal, Peter Andras, additional, Gadanya, Muktar A., additional, Gaidhane, Shilpa, additional, Gaipov, Abduzhappar, additional, Gakidou, Emmanuela, additional, Galali, Yaseen, additional, Gallus, Silvano, additional, Gandhi, Aravind P., additional, Ganesan, Balasankar, additional, Gautam, Rupesh K., additional, Gebregergis, Miglas W.W., additional, Gebrekidan, Kahsu Gebrekirstos, additional, Geleijnse, Johanna M., additional, Gerema, Urge, additional, Ghajar, Alireza, additional, Ghamari, Seyyed-Hadi, additional, Ghasemi, MohammadReza, additional, Dabaghi, Ghazal Ghasempour, additional, Ghasemzadeh, Afsaneh, additional, Ghazy, Ramy Mohamed, additional, Gholamalizadeh, Maryam, additional, Ghuge, Arun Digambarrao, additional, Gill, Paramjit Singh, additional, Gill, Tiffany K., additional, Gillum, Richard F., additional, Gnedovskaya, Elena V., additional, Golchin, Ali, additional, Goleij, Pouya, additional, Gorini, Giuseppe, additional, Goulart, Alessandra C., additional, Goyal, Anmol, additional, Goyal, Kashish, additional, Guan, Shi-Yang, additional, Guarducci, Giovanni, additional, Gudeta, Mesay Dechasa, additional, Guha, Avirup, additional, Guicciardi, Stefano, additional, Gulisashvili, David, additional, Gunawardane, Damitha Asanga, additional, Guo, Cui, additional, Gupta, Anish Kumar, additional, Gupta, Bhawna, additional, Gupta, Indarchand Ratanlal, additional, Gupta, Kartik, additional, Gupta, Mohak, additional, Gupta, Rajat Das, additional, Gupta, Rajeev, additional, Gupta, Renu, additional, Gupta, Sapna, additional, Gupta, Veer Bala, additional, Gupta, Vijai Kumar, additional, Gupta, Vivek Kumar, additional, Gurmessa, Lami, additional, Gutiérrez, Reyna Alma, additional, Habibzadeh, Farrokh, additional, Hadei, Mostafa, additional, Haeri Boroojeni, Helia Sadat, additional, Halimi, Aram, additional, Haller, Sebastian, additional, Halwani, Rabih, additional, Hamadeh, Randah R., additional, Hamdy, Nadia M., additional, Hamidi, Samer, additional, Han, Chieh, additional, Han, Qiuxia, additional, Hankey, Graeme J., additional, Hannan, Md. Abdul, additional, Hargono, Arief, additional, Haro, Josep Maria, additional, Hasan, Faizul, additional, Hasan, Ikramul, additional, Hasani, Hamidreza, additional, Hashemian, Maryam, additional, Hasnain, Md Saquib, additional, Hassan, Amr, additional, Hassan, Ikrama, additional, Haubold, Johannes, additional, Havmoeller, Rasmus J., additional, Hay, Simon I., additional, Hayat, Khezar, additional, Hbid, Youssef, additional, Hegazi, Omar E., additional, Hegena, Tadele Yohannes, additional, Heidari, Mohammad, additional, Helfer, Bartosz, additional, Herrera-Serna, Brenda Yuliana, additional, Herteliu, Claudiu, additional, Hesami, Hamed, additional, Hessami, Kamran, additional, Heydari, Keyvan, additional, Hezam, Kamal, additional, Hiraike, Yuta, additional, Hoan, Nguyen Quoc, additional, Holla, Ramesh, additional, Hossain, Md Mahbub, additional, Hossain, Md. Belal, additional, Hosseinzadeh, Hassan, additional, Hosseinzadeh, Mehdi, additional, Hostiuc, Mihaela, additional, Hostiuc, Sorin, additional, Hsairi, Mohamed, additional, Huang, Junjie, additional, Hultström, Michael, additional, Huynh, Hong-Han, additional, Hwang, Bing-Fang, additional, Ibrahim, Khalid S., additional, Idowu, Oluwatope Olaniyi, additional, Ilesanmi, Olayinka Stephen, additional, Ilic, Irena M., additional, Ilic, Milena D., additional, Immurana, Mustapha, additional, Inbaraj, Leeberk Raja, additional, Iqhrammullah, Muhammad, additional, Shariful Islam, Sheikh Mohammed, additional, Ismail, Faisal, additional, Ismail, Nahlah Elkudssiah, additional, Isola, Gaetano, additional, Iwagami, Masao, additional, J, Linda Merin, additional, Jaafari, Jalil, additional, Jacob, Louis, additional, Jafarzadeh, Abdollah, additional, Jaggi, Khushleen, additional, Jahrami, Haitham, additional, Jain, Akhil, additional, Jain, Nityanand, additional, Jairoun, Ammar Abdulrahman, additional, Jakovljevic, Mihajlo, additional, Jamora, Roland Dominic G., additional, Javadi, Nilofer, additional, Jayapal, Sathish Kumar, additional, Jayaram, Shubha, additional, Jebai, Rime, additional, Jeben, Rebuma Sorsa, additional, Jee, Sun Ha, additional, Jha, Anil K., additional, Jha, Ravi Prakash, additional, Jha, Vivekanand, additional, Jiang, Heng, additional, Jin, Yinzi, additional, Jobanputra, Yash B., additional, Johnson, Catherine Owens, additional, Jokar, Mohammad, additional, Joo, Tamas, additional, Joseph, Abel, additional, Joseph, Nitin, additional, Joshua, Charity Ehimwenma, additional, Jozwiak, Jacek Jerzy, additional, Jürisson, Mikk, additional, Kabir, Ali, additional, Kabir, Zubair, additional, Kadashetti, Vidya, additional, Kahe, Farima, additional, Kalani, Rizwan, additional, Kalankesh, Laleh R., additional, Kalantar, Farnaz, additional, Kalkonde, Yogeshwar, additional, Kalra, Sanjay, additional, Kamath, Ashwin, additional, Kamath, Sagarika, additional, Kamireddy, Arun, additional, Kanchan, Tanuj, additional, Kandel, Himal, additional, Kanmanthareddy, Arun R., additional, Kanmodi, Kehinde Kazeem, additional, Kansal, Sushil Kumar, additional, Kapner, Daniel John, additional, Kar, Sitanshu Sekhar, additional, Karakasis, Paschalis, additional, Karki, Prabin, additional, Kashoo, Faizan Zaffar, additional, Kasraei, Hengameh, additional, Kassahun, Eskeziaw Abebe, additional, Kassebaum, Nicholas J., additional, Katoto, Patrick D.M. 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30. Global Burden of Cardiovascular Diseases and Risks, 1990-2022
- Author
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Mensah, G, Fuster, V, Murray, C, Roth, G, Abate, Y, Abbasian, M, Abd-Allah, F, Abdollahi, A, Abdollahi, M, Abdulah, D, Abdullahi, A, Abebe, A, Abedi, A, Abiodun, O, Ali, H, Abu-Gharbieh, E, Abu-Rmeileh, N, Aburuz, S, Abushouk, A, Abu-Zaid, A, Adane, T, Adderley, N, Adebayo, O, Aden, B, Adeyeoluwa, T, Adeyomoye, O, Sakilah Adnani, Q, Afrashteh, F, Afyouni, S, Afzal, S, Agasthi, P, Agodi, A, Aguilera Arriagada, C, Agyemang-Duah, W, Ahinkorah, B, Ahmad, A, Ahmad, D, Ahmad, F, Ahmad, M, Ahmed, A, Ahmed, H, Ahmed, M, Ahmed, S, Ajami, M, Akinosoglou, K, Ala, M, Ali AL-Ahdal, T, Alalalmeh, S, Al-Aly, Z, Alam, N, Al-amer, R, Alashi, A, Albashtawy, M, Albataineh, M, Alema, H, Alemi, S, Alemu, Y, Saeed Al-Gheethi, A, Alhabib, K, Naji Alhalaiqa, F, Ali, M, Ali, R, Pursuing, P, Shujait Ali, S, Alicandro, G, Alikhani, R, Aljunid, S, Alla, F, Almahmeed, W, Al-Marwani, S, Alonso, J, Al-Raddadi, R, Alvi, F, Alvis-Guzman, N, Alvis-Zakzuk, N, Alwafi, H, Aly, H, Amegbor, P, Amin, T, Amindarolzarbi, A, Amini-Rarani, M, Amiri, S, Ammirati, E, Anand, T, Ancuceanu, R, Anderlini, D, Anil, A, Ansari, G, Anyanwu, P, Anyasodor, A, Carace Apostol, G, Arabloo, J, Arafat, M, Aravkin, A, Aremu, O, Armocida, B, Arnlov, J, Arowosegbe, O, Artamonov, A, Artanti, K, Arulappan, J, Aruleba, I, Arumugam, A, Aryan, Z, Asghari-Jafarabadi, M, Astell-Burt, T, Ataei, M, Athar, M, Atreya, A, Aujayeb, A, Awotidebe, A, Aynalem, A, Azizi, Z, Azzam, A, Babu, A, Badar, M, Bader, F, Badiye, A, Bagga, A, Bagherieh, S, Asl, F, Bai, R, Baker, J, Bakkannavar, S, Bako, A, Bakshi, R, Balogun, S, Baltatu, O, Bam, K, Banach, M, Bandyopadhyay, S, Banik, B, Chandra Banik, P, Bansal, K, Baradaran, H, Barbic, F, Barchitta, M, Bardhan, M, Barker-Collo, S, Barnighausen, T, Barone-Adesi, F, Barteit, S, Barua, L, Bashiri, A, Bayati, M, Bayileyegn, N, Behboudi, E, Behnoush, A, Bejot, Y, Belay, S, Belete, M, Belgaumi, U, Bell, M, Belo, L, Bendak, S, Benfor, B, Bennett, D, Bensenor, I, Benziger, C, Beran, A, Berman, A, Bermudez, A, Bertolacci, G, Beyene, H, Beyene, K, Srikanth Bhagavathula, A, Bhardwaj, N, Bhardwaj, P, Bhat, V, Bhatti, G, Bhatti, J, Bikbov, B, Bikov, A, Birck, M, Biswas, B, Bitaraf, S, Bodunrin, A, Bogale, E, Bogale, K, Boloor, A, Hashemi, M, Borhany, H, Boyko, E, Braithwaite, D, Brant, L, Brauer, M, Breitner, S, Briko, A, Bulto, L, Bustanji, Y, Butt, Z, Calina, D, Cao, F, Cardenas, R, Carr, S, Carreras, G, Carrero, J, Carvalho, M, Castaldelli-Maia, J, Castaneda-Orjuela, C, Cattaruzza Luca Cegolon, M, Cerin, E, Chahine, Y, Kai Chan, J, Chan, M, Chan, R, Charalampous, P, Charan, J, Chattu, V, Chen, A, Chen, C, Chen, H, Chennapragada, S, Chew, D, Chi, G, Ching, P, Chitheer, A, Jemma Cho, S, Cho, W, Chong, B, Chopra, H, Choudhary, R, Chowdhury, E, Chowdhury, R, Chu, D, Chukwu, I, Giuseppe Cicero, A, Cindi, Z, Cioffi, I, Coberly, K, Coffey, S, Columbus, A, Conde, J, Conti, S, Corso, B, Cortes, S, Cortesi, P, Costa, V, Couto, R, Cowart, E, Criqui, M, Cruz, J, Dadana, S, Dadras, O, Dai, X, Dai, Z, Dalaba, M, Moura Damasceno, A, Damiani, G, D'Amico, E, Das, S, Dashti, M, Dashtkoohi, M, Dastmardi, M, Davletov, K, Debele, A, Debopadhaya, S, Decleene, N, Delgado-Enciso, I, Delgado-Saborit, J, Demessa, B, Demetriades, A, Deng, X, Denova-Gutierrez, E, Dereje, N, Asrat Derese, A, Desai, H, Desai, R, Chellaiyan Devanbu, V, Rahman Dewan, S, Dey, S, Dhulipala, V, Diaz, D, Diaz, M, Ding, D, Dinis-Oliveira, R, Do, T, Phuong Do, T, Doaei, S, Dohare, S, Dong, W, D'Oria, M, Mombaque dos Santos, W, Douiri, A, Dowou, R, Dsouza, A, Dsouza, H, Dsouza, V, Du, M, Duraes, A, Durojaiye, O, Dutta, S, Dziedzic, A, Ebrahimi, A, Efendi, D, Efendi, F, Effendi, D, Eini, E, Ekholuenetale, M, Ekundayo, T, El Sayed, I, El Tantawi, M, Elbarazi, I, Elgar, F, Elgendy, I, Elhadi, M, El-Huneidi, W, Emamverdi, M, Emeto, T, Erkhembayar, R, Eshetie, T, Espinosa-Montero, J, Etaee, F, Fabin, N, Fadhil, I, Fagbamigbe, A, Falzone, L, Sofia e Sa Farinha, C, Faris, M, Faro, A, Faruque, M, Farwati, M, Fasanmi, A, Fatehizadeh, A, Fazeli, P, Feigin, V, Feng, X, Fereshtehnejad, S, Feroze, A, Ferrara, P, Ferreira, N, Filip, I, Fleszar, L, Flood, D, Folayan, M, Fomenkov, A, Fonseca, D, Fornari, C, Foschi, M, Franklin, R, Fukumoto, T, Blimafux, P, Gaal, P, Gadanya, M, Gaidhane, S, Gaipov, A, Gakidou, E, Galali, Y, Gallus, S, Gandhi, A, Ganesan, B, Gautam, R, Gebregergis, M, Gebrekidan, K, Geleijnse, J, Gerema, U, Ghajar, A, Ghamari, S, Ghasemi, M, Dabaghi, G, Ghasemzadeh, A, Ghazy, R, Gholamalizadeh, M, Ghuge, A, Gill, P, Gill, T, Gillum, R, Gnedovskaya, E, Golchin, A, Goleij, P, Gorini, G, Goulart, A, Goyal, A, Goyal, K, Guan, S, Guarducci, G, Gudeta, M, Guha, A, Guicciardi, S, Gulisashvili, D, Gunawardane, D, Guo, C, Gupta, A, Gupta, B, Gupta, I, Gupta, K, Gupta, M, Gupta, R, Gupta, S, Gupta, V, Gurmessa, L, Gutierrez, R, Habibzadeh, F, Hadei, M, Haeri Boroojeni, H, Halimi, A, Haller, S, Halwani, R, Hamadeh, R, Hamdy, N, Hamidi, S, Han, C, Han, Q, Hankey, G, Hannan, M, Hargono, A, Haro, J, Hasan, F, Hasan, I, Hasani, H, Hashemian, M, Hasnain, M, Hassan, A, Hassan, I, Haubold, J, Havmoeller, R, Hay, S, Hayat, K, Hbid, Y, Hegazi, O, Hegena, T, Heidari, M, Helfer, B, Herrera-Serna, B, Herteliu, C, Hesami, H, Hessami, K, Heydari, K, Hezam, K, Hiraike, Y, Hoan, N, Holla, R, Hossain, M, Hosseinzadeh, H, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Hsairi, M, Huang, J, Hultstrom, M, Huynh, H, Hwang, B, Ibrahim, K, Idowu, O, Ilesanmi, O, Ilic, I, Ilic, M, Immurana, M, Inbaraj, L, Iqhrammullah, M, Shariful Islam, S, Ismail, F, Ismail, N, Isola, G, Iwagami, M, J, L, Jaafari, J, Jacob, L, Jafarzadeh, A, Jaggi, K, Jahrami, H, Jain, A, Jain, N, Jairoun, A, Jakovljevic, M, Jamora, R, Javadi, N, Jayapal, S, Jayaram, S, Jebai, R, Jeben, R, Jee, S, Jha, A, Jha, R, Jha, V, Jiang, H, Jin, Y, Jobanputra, Y, Johnson, C, Jokar, M, Joo, T, Joseph, A, Joseph, N, Joshua, C, Jozwiak, J, Jurisson, M, Kabir, A, Kabir, Z, Kadashetti, V, Kahe, F, Kalani, R, Kalankesh, L, Kalantar, F, Kalkonde, Y, Kalra, S, Kamath, A, Kamath, S, Kamireddy, A, Kanchan, T, Kandel, H, Kanmanthareddy, A, Kanmodi, K, Kansal, S, Kapner, D, Kar, S, Karakasis, P, Karki, P, Kashoo, F, Kasraei, H, Kassahun, E, Kassebaum, N, Katoto, P, Kaydi, N, Kazemi, F, Kazemian, S, Kazeminia, S, Kerr, J, Kesse-Guyot, E, Keykhaei, M, Khadembashiri, M, Khafaie, M, Khajuria, H, Khalaji, A, Khalid, N, Khalilian, A, Khalilov, R, Khan, A, Khan, E, Khan, J, Khan, M, Khan, Y, Khan suheb, M, Khanmohammadi, S, Khatab, K, Khateri, S, Khayat Kashani, H, Kheirallah, K, Khidri, F, Kian, S, Kifle, Z, Kimokoti, R, Kisa, A, Kisa, S, Kolahi, A, Kompani, F, Koren, G, Kotnis, A, Koul, P, Koyanagi, A, Krishan, K, Krishna, H, Krishnamoorthy, V, Krishnamoorthy, Y, Kuddus, M, Kulimbet, M, Kulkarni, V, Kumar, A, Kumar, N, Kumar, R, Kumsa, N, Kunle, K, Kusuma, D, Kyriopoulos, I, La Vecchia, C, Lacey, B, Ladan, M, Laflamme, L, Lahariya, C, Lahiri, A, Ching Lai, D, Lallukka, T, Lan, Q, Landires, I, Lanfranchi, F, Larijani, B, Larsson, A, Lasrado, S, Latief Epidemiology, K, Latifinaibin, K, Lau, J, Lauriola, P, Le, K, Dao Le, L, Hanh Le, N, Thu Le, T, Thanh Le, T, Bich Le, T, Ledda, C, Lee, M, Lee, P, Lee, S, Lee, W, Lee, Y, Legrand, K, Leinsalu, M, Leonardi, M, Lerango, T, Li, A, Li, M, Li, W, Li, X, Li, Y, Lim, L, Lim, S, Lin, R, Lindstrom, M, Linn, S, Liu, G, Liu, S, Liu, X, Livingstone, K, Llanaj, E, Lopukhov, P, Sci (Med), C, Loreche, A, Lorenzovici, L, Lorkowski, S, Lotufo, P, Lucchetti, G, Lugo, A, Ma, Z, Madadizadeh, F, Maddison, R, Magana Gomez, J, Magne, J, Prasad, D, Mahalleh, M, Mahmoud, M, Mahmoudi, E, Mahmoudvand, B, Makram, O, Rad, E, Malekzadeh, R, Malhotra, K, Malik, I, Ahmed Malik, M, Mallhi, T, Malta, D, Manilal, A, Manla, Y, Mansoori, Y, Mansouri, B, Mansouri, P, Mansournia, M, Marateb, H, Marino, M, Martini, D, Martini, S, Maryam, S, Marzo, R, Masoudi, A, Masoudi, S, Matei, C, Mathangasinghe, Y, Mathews, E, Mathur, M, Mattumpuram, J, Maude, R, Maugeri, A, Mayeli, M, Mazidi, M, Mcgrath, J, Mcphail, S, Mechili, E, Carabeo Medina, J, Meena, J, Mehrabani-Zeinabad, K, Mendez Mendez-Lopez, M, Mendoza, W, Menezes, R, Mengist, B, Meo, S, Meresa, H, Meretoja, A, Meretoja, T, Mestrovic, T, Dinushi Mettananda, K, Mettananda, S, Mhlanga, L, Mi, T, Jonasson, J, Miazgowski, T, Michalek, I, Miller, T, Nhat Minh, L, Minja, N, Mohammad Sadeghi, P, Mirdamadi, N, Mirica, A, Mirrakhimov, E, Mirza, M, Mirza-Aghazadeh-Attari, M, Mithra, P, Moghimi, Z, Mohamed, J, Mohamed, M, Mohamed, N, Mohammadi, S, Mohammed, H, Mohammed, M, Mohammed, S, Moka, N, Mokdad, A, Vardanjani, H, Momtazmanesh, S, Monasta, L, Montazeri, F, Ghalibaf, A, Moradi, Y, Moraga, P, Morawska, L, Morovatdar, N, Morrison, S, Morze, J, Mostafavi, E, Mostofinejad, A, Mougin, V, Mousavi, P, Mousavi, S, Mozaffarian, D, Msherghi, A, Muccioli, L, Mueller, U, Mukherjee, S, Munjal, K, Murillo-Zamora, E, Mustafa, G, Muthu, S, Mwita, J, Myung, W, Nagarajan, A, Nagaraju, S, Naik, G, Nair, T, Najafi, M, Ansari, N, Nangia, V, Swamy, S, Nargus, S, Nascimento, B, Nascimento, G, Nasoori, H, Natto, Z, Nauman, J, Naveed, M, Nayak, B, Nayak, V, Negash, H, Negoi, I, Negoi, R, Shahrokh Abadi, R, Nejadghaderi, S, Nejjari, C, Nematollahi, M, Nepal, S, Ng, N, Nguyen, D, Nguyen, P, Nguyen, V, Niazi, R, Nijjar, S, Nizam, M, Noman, E, Nomura, S, Noreen, M, Norrving, B, Noubiap, J, Nri-Ezedi, C, Ntsekhe, M, Nurrika, D, Nzoputam, C, Nzoputam, O, Obamiro, K, O'Donnell, M, Oghenetega, O, Oguntade, A, Oguta, J, Okeke, S, Okekunle, A, Okidi, L, Okonji, O, Okwute, P, Olagunju, A, Olaiya, M, Olana, M, Olatubi, M, Moraes Oliveira, G, Olorukooba, A, Olufadewa, I, Oluwafemi, Y, Oluwatunase, G, Omer, G, Ommati, M, Ong, K, Ong, S, Onyedibe, K, Ordak, M, Ortega-Altamirano, D, Ortiz, A, Ortiz-Prado, E, Osman, W, Osuagwu, U, Otoiu, A, Otstavnov, S, Owolabi, M, Padukudru P A, M, Padron-Monedero, A, Padubidri, J, Varnosfaderani, M, Palicz, T, Palladino, R, Pan, F, Pan, H, Pandi-Perumal, S, Papadopoulou, P, Park, S, Passera, R, Patel, J, Patil, S, Patoulias, D, Patthipati, V, Pawar, S, Peden, A, Pedersini, P, Peng, M, Filipino Pepito, V, Peprah, E, Pereira, M, Peres, M, Perianayagam, A, Perico, N, Petermann-Rocha, F, Pham, H, Philip, A, Pigott, D, Pilgrim, T, Piradov, M, Plotnikov, E, Poddighe, D, Polibin, R, Poluru, R, Pourali, G, Pourshams, A, Singh Pradhan, P, Prasad, M, Sady Prates, E, Purohit, B, Puvvula, J, Qattea, I, Qian, G, Qureshi, M, Rabiee rad, M, Radfar, A, Rafiei Alavi, S, Rafique, I, Raggi, A, Rahim, F, Rahim, M, Rahimi, M, Rahman, M, Rahmani, A, Rahmani, B, Rahmani, S, Rahmanian, V, Rai, P, Rajaa, S, Rajabpour-Sanati, A, Rajput, P, Ram, P, Ramalingam, S, Ramasamy, S, Ramazanu, S, Ramesh, P, Rana, J, Rana, K, Ranabhat, C, Rancic, N, Rane, A, Ranjan, S, Ranta, A, Rao, I, Rao, M, Rao, S, Rashedi, S, Rashedi, V, Rashid, A, Rasul, A, Ratan, Z, Babu, G, Ravikumar, N, Rawaf, S, Razeghian-Jahromi, I, Razo, C, Rama Krishna Reddy, M, Mohamed Redwan, E, Remuzzi, G, Reyes, L, Rezaei, N, Rezaeian, M, Ribeiro, A, Ribeiro, D, Rikhtegar, R, Roever, L, Romadlon, D, Ronfani, L, Sekhar Rout, H, Roy, N, Roy, P, Rynkiewicz, A, Saad, A, Saadatian, Z, Sabour, S, Sacco, S, Sachdeva, R, Saddik, B, Sadeghi, E, Saeed, U, Safaeinejad, F, Sharif-Askari, F, Sharif-Askari, N, Sahebkar, A, Sahoo, S, Sajedi, S, Sajid, M, Sakshaug, J, Salam, N, Salami, A, Saleh, M, Salehi, S, Salem, M, Samadzadeh, S, Samargandy, S, Samuel, V, Samy, A, Sanabria, J, Sanjeev, R, Santric-Milicevic, M, Nadeem Saqib, M, Sarasmita, M, Saravanan, A, Sarikhani, Y, Sarkar, T, Sarmiento-Suarez, R, Sarode, G, Sarode, S, Sathish, T, Sathyanarayan, A, Sawhney, M, Sayyah, M, Scarmeas, N, Schaarschmidt, B, Schuermans, A, Schumacher, A, Schutte, A, Schwebel, D, Sedighi, M, Seidu, A, Semnani, F, Senapati, S, Sengupta, P, Senthilkumaran, S, Sepanlou, S, Sethi, Y, Seyedi, S, Seylani, A, Shabany, M, Shafeghat, M, Shafie, M, Shah, P, Shahbandi, A, Shahid, I, Shahid, S, Shahid, W, Shahwan, M, Shaikh, M, Sham, S, Shamim, M, Shanawaz, M, Sharfaei, S, Sharifan, A, Sharifi-Rad, J, Sharma, P, Sharma, S, Sharma, U, Sharma, V, Sheikh, A, Shiferaw, D, Shigematsu, M, Shin, M, Shiri, R, Shishani, K, Shittu, A, Shiue, I, Shivakumar, K, Shrestha, S, Shuval, K, Sibhat, M, Sigfusdottir, I, Simpson, C, Singh, A, Singh, J, Singh, P, Singh, R, Singh, S, Siraj, M, Skryabin, V, Skryabina, A, Sleet, D, Soleimani, H, Solikhah, S, Soliman, S, Son, J, Song, S, Song, Y, Soriano, J, Spartalis, M, Sreeramareddy, C, Stafford, L, Stark, B, Steiropoulos, P, Stortecky, S, Abdulkader, R, Sultana, A, Sundstrom, J, Swain, C, Damavandi, P, Tabatabaei, S, Malazy, O, Tabatabaeizadeh, S, Tabatabai, S, Tabb, K, Tabish, M, Tabuchi, T, Tadese, F, Abkenar, Y, Taiba, J, Talaat, I, Tampa, M, Lukenze Tamuzi, J, Tan, K, Tang, H, Tarkang, E, Tat, N, Tavangar, S, Tehrani, H, Teimoori, M, Temsah, M, Hani Temsah, R, Teramoto, M, Thangaraju, P, Thankappan, K, Thapa, R, Thapar, R, Thavamani, A, Thayakaran, R, Thomas, N, Tian, J, Tichopad, A, Tillawi, T, Tonelli, M, Topor-Madry, R, Touvier, M, Tovani-Palone, M, Tran, J, Tran, N, Van Tran, P, Trihandini, I, Tripathi, A, Tromans, S, Truong, V, Tri Tai Truyen, T, Tsatsakis, A, Tsegay, G, Tsermpini, E, Tumurkhuu, M, Tung, K, Ubah, C, Udoakang, A, Udoh, A, Ullah, A, Ullah, S, Umair, M, Umar, T, Unim, B, Unnikrishnan, B, Upadhyay, E, Usman, J, Vahabi, S, Vaithinathan, A, Valizadeh, R, Van den Eynde, J, Varga, O, Varma, S, Vart, P, Varthya, S, Vasankari, T, Vellingiri, B, Vervoort, D, Villafane, J, Violante, F, Viskadourou, M, Volovat, S, Vos, T, Vujcic, I, Wafa, H, Wahab, F, Wang, C, Wang, F, Wang, N, Wang, S, Wang, Y, Wei, M, Werdecker, A, Wickramasinghe, N, Wijeratne, T, Wilandika, A, Wilson, S, Wolfe, C, Wongsin, U, Wu, Z, Xiao, H, Xu, S, Xu, X, Yadav, L, Yano, Y, Yaribeygi, H, Yasufuku, Y, Nia, I, Ye, P, Yesuf, S, Yezli, S, Yigit, A, Yigit, V, Yilma, M, Yon, D, Yonemoto, N, Yousefi, Z, Yperzeele, L, Yu, C, Yunusa, I, Zafari, N, Tajrishi, F, Zakham, F, Zastrozhin, M, Zeineddine, M, Zemedikun, D, Zeng, Y, Zhai, C, Zhang, C, Zhang, H, Zhang, L, Zhang, N, Zhang, Y, Zhao, H, Zheng, P, Zhong, C, Zhou, S, Zhu, B, Zhu, L, Zielinska, M, Zikarg, Y, Zmaili, M, Zoeckler, L, Zou, Z, Zumla, A, Zweck, E, Zyoud, S, Mensah G. A., Fuster V., Murray C. J. L., Roth G. A., Abate Y. H., Abbasian M., Abd-Allah F., Abdollahi A., Abdollahi M., Abdulah D. M., Abdullahi A., Abebe A. M., Abedi A., Abiodun O. O., Ali H. A., Abu-Gharbieh E., Abu-Rmeileh N. M. E., Aburuz S., Abushouk A. I., Abu-Zaid A., Adane T. D., Adderley N. J., Adebayo O. M., Aden B., Adeyeoluwa T. E., Adeyomoye O. I., Sakilah Adnani Q. E., Afrashteh F., Afyouni S., Afzal S., Agasthi P., Agodi A., Aguilera Arriagada C. E., Agyemang-Duah W., Ahinkorah B. O., Ahmad A., Ahmad D., Ahmad F., Ahmad M. M., Ahmed A., Ahmed H., Ahmed M. B., Ahmed S. A., Ajami M., Akinosoglou K., Ala M., Ali AL-Ahdal T. M., Alalalmeh S. O., Al-Aly Z., Alam N., Al-amer R. M., Alashi A., Albashtawy M., AlBataineh M. T., Alema H. B., Alemi S., Alemu Y. M., Saeed Al-Gheethi A. A., Alhabib K. F., Naji Alhalaiqa F. A., Ali M. U., Ali R., pursuing P., Shujait Ali S. S., Alicandro G., Alikhani R., Aljunid S. M., Alla F., Almahmeed W., Al-Marwani S., Alonso J., Al-Raddadi R. M., Alvi F. J., Alvis-Guzman N., Alvis-Zakzuk N. J., Alwafi H., Aly H., Amegbor P. M., Amin T. T., Amindarolzarbi A., Amini-Rarani M., Amiri S., Ammirati E., Anand T., Ancuceanu R., Anderlini D., Anil A., Ansari G., Anyanwu P. E., Anyasodor A. E., Carace Apostol G. L., Arabloo J., Arafat M., Aravkin A. Y., Aremu O., Armocida B., Arnlov J., Arowosegbe O. O., Artamonov A. A., Artanti K. D., Arulappan J., Aruleba I. T., Arumugam A., Aryan Z., Asghari-Jafarabadi M., Astell-Burt T., Ataei M., Athar M., Atreya A., Aujayeb A., Awotidebe A. W., Aynalem A. A., Azizi Z., Azzam A. Y., Babu A. S., Badar M., Bader F., Badiye A. D., Bagga A., Bagherieh S., Asl F. B., Bai R., Baker J. L., Bakkannavar S. M., Bako A. T., Bakshi R. K., Balogun S. A., Baltatu O. C., Bam K., Banach M., Bandyopadhyay S., Banik B., Chandra Banik P., Bansal K., Baradaran H. R., Barbic F., Barchitta M., Bardhan M., Barker-Collo S. L., Barnighausen T. W., Barone-Adesi F., Barteit S., Barua L., Bashiri A., Bayati M., Bayileyegn N. S., Behboudi E., Behnoush A. H., Bejot Y., Belay S. A., Belete M. A., Belgaumi U. I., Bell M. L., Belo L., Bendak S., Benfor B., Bennett D. A., Bensenor I. M., Benziger C. P., Beran A., Berman A. E., Bermudez A. N. C., Bertolacci G. J., Beyene H. B., Beyene K. A., Srikanth Bhagavathula A. S., Bhardwaj N., Bhardwaj P., Bhardwaj P. V., Bhat V., Bhatti G. K., Bhatti J. S., Bikbov B., Bikov A., Birck M. G., Biswas B., Bitaraf S., Bodunrin A. O., Bogale E. K., Bogale K. A., Boloor A., Hashemi M. B., Borhany H., Boyko E. J., Braithwaite D., Brant L. C., Brauer M., Breitner S., Briko A., Bulto L. N., Bustanji Y., Butt Z. A., Calina D., Cao F., Cardenas R., Carr S., Carreras G., Carrero J. J., Carvalho M., Castaldelli-Maia J. M., Castaneda-Orjuela C. A., Cattaruzza Luca Cegolon M. S., Cerin E., Chahine Y., Kai Chan J. S., Chan M. Y., Chan R. N. C., Charalampous P., Charan J., Chattu V. K., Chen A. -T., Chen C. 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Y., Herteliu C., Hesami H., Hessami K., Heydari K., Hezam K., Hiraike Y., Hoan N. Q., Holla R., Hossain M. M., Hossain M. B., Hosseinzadeh H., Hosseinzadeh M., Hostiuc M., Hostiuc S., Hsairi M., Huang J., Hultstrom M., Huynh H. -H., Hwang B. -F., Ibrahim K. S., Idowu O. O., Ilesanmi O. S., Ilic I. M., Ilic M. D., Immurana M., Inbaraj L. R., Iqhrammullah M., Shariful Islam S. M., Ismail F., Ismail N. E., Isola G., Iwagami M., J L. M., Jaafari J., Jacob L., Jafarzadeh A., Jaggi K., Jahrami H., Jain A., Jain N., Jairoun A. A., Jakovljevic M., Jamora R. D. G., Javadi N., Jayapal S. K., Jayaram S., Jebai R., Jeben R. S., Jee S. H., Jha A. K., Jha R. P., Jha V., Jiang H., Jin Y., Jobanputra Y. B., Johnson C. O., Jokar M., Joo T., Joseph A., Joseph N., Joshua C. E., Jozwiak J. J., Jurisson M., Kabir A., Kabir Z., Kadashetti V., Kahe F., Kalani R., Kalankesh L. R., Kalantar F., Kalkonde Y., Kalra S., Kamath A., Kamath S., Kamireddy A., Kanchan T., Kandel H., Kanmanthareddy A. R., Kanmodi K. K., Kansal S. K., Kapner D. J., Kar S. S., Karakasis P., Karki P., Kashoo F. Z., Kasraei H., Kassahun E. A., Kassebaum N. J., Katoto P. D. M. C., Kaydi N., Kazemi F., Kazemian S., Kazeminia S., Kerr J. A., Kesse-Guyot E., Keykhaei M., Khadembashiri M. M., Khadembashiri M. A., Khafaie M. A., Khajuria H., Khalaji A., Khalid N., Khalilian A., Khalilov R., Khan A., Khan E. A., Khan J., Khan M. N., Khan M., Khan M. J., Khan M. S., Khan Y. H., Khan suheb M. Z., Khanmohammadi S., Khatab K., Khateri S., Khayat Kashani H. R., Kheirallah K. A., Khidri F. F., Kian S., Kifle Z. D., Kimokoti R. W., Kisa A., Kisa S., Kolahi A. -A., Kompani F., Koren G., Kotnis A. L., Koul P. A., Koyanagi A., Krishan K., Krishna H., Krishnamoorthy V., Krishnamoorthy Y., Kuddus M. A., Kuddus M., Kulimbet M., Kulkarni V., Kumar A., Kumar N., Kumar R., Kumsa N. B., Kunle K. R., Kusuma D., Kyriopoulos I., La Vecchia C., Lacey B., Ladan M. A., Laflamme L., Lahariya C., Lahiri A., Ching Lai D. T., Lallukka T., Lan Q., Landires I., Lanfranchi F., Larijani B., Larsson A. O., Lasrado S., Latief Epidemiology K., Latifinaibin K., Lau J., Lauriola P., Le K., Dao Le L. K., Hanh Le N. H., Thu Le T. T., Thanh Le T. D., Bich Le T. T., Ledda C., Lee M., Lee P. H., Lee S. W., Lee W. -C., Lee Y. H., LeGrand K. E., Leinsalu M., Leonardi M., Lerango T. L., Li A., Li M. -C., Li W., Li X., Li Y., Lim L. -L., Lim S. S., Lin R. -T., Lindstrom M., Linn S., Liu G., Liu S., Liu X., Livingstone K. M., Llanaj E., Lopukhov P. D., Sci (Med) C. O., Loreche A. M., Lorenzovici L., Lorkowski S., Lotufo P. A., Lucchetti G., Lugo A., Ma Z. F., Madadizadeh F., Maddison R., Magana Gomez J. A., Magne J., Prasad D. R. M., Mahalleh M., Mahmoud M. A., Mahmoudi E., Mahmoudvand B., Makram O. M., Rad E. M., Malekzadeh R., Malhotra K., Malik I., Ahmed Malik M. S., Mallhi T. H., Malta D. C., Manilal A., Manla Y., Mansoori Y., Mansouri B., Mansouri P., Mansournia M. A., Marateb H. R., Marino M., Martini D., Martini S., Maryam S., Marzo R. R., Masoudi A., Masoudi S., Matei C. N., Mathangasinghe Y., Mathews E., Mathur M. R., Mattumpuram J., Maude R. J., Maugeri A., Mayeli M., Mazidi M., McGrath J. J., McPhail S. M., Mechili E. A., Carabeo Medina J. R., Meena J. K., Mehrabani-Zeinabad K., Mendez Mendez-Lopez M. A., Mendoza W., Menezes R. G., Mengist B., Meo S. A., Meresa H. A., Meretoja A., Meretoja T. J., Mestrovic T., Dinushi Mettananda K. C., Mettananda S., Mhlanga L., Mi T., Jonasson J. M., Miazgowski T., Michalek I. M., Miller T. R., Nhat Minh L. H., Minja N. W., Mohammad Sadeghi P. M., Mirdamadi N., Mirica A., Mirrakhimov E. M., Mirza M., Mirza-Aghazadeh-Attari M., Mithra P., Moghimi Z., Mohamed J., Mohamed M. F. H., Mohamed N. S., Mohammadi S., Mohammed H., Mohammed M., Mohammed S., Moka N., Mokdad A. H., Vardanjani H. M., Momtazmanesh S., Monasta L., Montazeri F., Ghalibaf A. M., Moradi Y., Moraga P., Morawska L., Morovatdar N., Morrison S. D., Morze J., Mostafavi E., Mostofinejad A., Mougin V., Mousavi P., Mousavi S. E., Mozaffarian D., Msherghi A., Muccioli L., Mueller U. O., Mukherjee S., Munjal K., Murillo-Zamora E., Mustafa G., Muthu S., Mwita J. C., Myung W., Nagarajan A. J., Nagaraju S. P., Naik G. R., Naik G., Nair T. S., Najafi M. S., Ansari N. N., Nangia V., Swamy S. N., Nargus S., Nascimento B. R., Nascimento G. G., Nasoori H., Natto Z. S., Nauman J., Naveed M., Nayak B. P., Nayak V. C., Negash H., Negoi I., Negoi R. I., Shahrokh Abadi R. N., Nejadghaderi S. A., Nejjari C., Nematollahi M. H., Nepal S., Ng N., Nguyen D. H., Nguyen P. T., Nguyen V. T., Niazi R. K., Nijjar S. S., Nizam M. A., Noman E. A., Nomura S., Noreen M., Norrving B., Noubiap J. J., Nri-Ezedi C. A., Ntsekhe M., Nurrika D., Nzoputam C. I., Nzoputam O. J., Obamiro K. O., O'Donnell M. J., Oghenetega O. B., Oguntade A. S., Oguta J. O., Okeke S. R., Okekunle A. P., Okidi L., Okonji O. C., Okwute P. G., Olagunju A. T., Olaiya M. T., Olana M. D., Olatubi M. I., Moraes Oliveira G. M., Olorukooba A. A., Olufadewa I. I., Oluwafemi Y. D., Oluwatunase G. O., Omer G. L., Ommati M. M., Ong K. L., Ong S., Onyedibe K. I., Ordak M., Ortega-Altamirano D. V., Ortiz A., Ortiz-Prado E., Osman W. M. S., Osuagwu U. L., Otoiu A., Otstavnov S. S., Owolabi M. O., Padukudru P A M., Padron-Monedero A., Padubidri J. R., Varnosfaderani M. P., Palicz T., Palladino R., Pan F., Pan H. -F., Pandi-Perumal S. R., Papadopoulou P., Park S., Passera R., Patel J., Patil S., Patoulias D., Patthipati V. S., Pawar S., Peden A. E., Pedersini P., Peng M., Filipino Pepito V. C., Peprah E. K., Pereira M., Pereira M. O., Peres M. F. P., Perianayagam A., Perico N., Petermann-Rocha F. E., Pham H. T., Philip A. K., Pigott D. M., Pilgrim T., Piradov M. A., Plotnikov E., Poddighe D., Polibin R. V., Poluru R., Pourali G., Pourshams A., Singh Pradhan P. M., Prasad M., Sady Prates E. J., Purohit B. M., Puvvula J., Qattea I., Qian G., Qureshi M. F., Rabiee rad M., Radfar A., Rafiei Alavi S. N., Rafique I., Raggi A., Rahim F., Rahim M. J., Rahimi M., Rahman M., Rahman M. A., Rahmani A. M., Rahmani B., Rahmani S., Rahmanian V., Rai P., Rajaa S., Rajabpour-Sanati A., Rajput P., Ram P., Ramalingam S., Ramasamy S. K., Ramazanu S., Ramesh P. S., Rana J., Rana K., Ranabhat C. L., Rancic N., Rane A., Ranjan S., Ranta A., Rao I. R., Rao M., Rao S. J., Rashedi S., Rashedi V., Rashid A. M., Rasul A., Ratan Z. A., Babu G. R., Ravikumar N., Rawaf S., Razeghian-Jahromi I., Razo C., Rama Krishna Reddy M. M., Mohamed Redwan E. M., Remuzzi G., Reyes L. F., Rezaei N., Rezaeian M., Ribeiro A. L. P., Ribeiro D., Rikhtegar R., Roever L., Romadlon D. S., Ronfani L., Sekhar Rout H. S., Roy N., Roy P., Rynkiewicz A., Saad A. M. A., Saadatian Z., Sabour S., Sacco S., Sachdeva R., Saddik B., Sadeghi E., Saeed U., Safaeinejad F., Sharif-Askari F. S., Sharif-Askari N. S., Sahebkar A., Sahoo S. S., Sajedi S. A., Sajid M. R., Sakshaug J. W., Salam N., Salami A. A., Saleh M. A., Salehi S., Salem M. R., Salem M. Z. Y., Samadzadeh S., Samargandy S., Samuel V. P., Samy A. M., Sanabria J., Sanjeev R. K., Santric-Milicevic M. M., Nadeem Saqib M. A., Sarasmita M. A., Saravanan A., Sarikhani Y., Sarkar T., Sarmiento-Suarez R., Sarode G. S., Sarode S. C., Sathish T., Sathyanarayan A., Sawhney M., Sayyah M., Scarmeas N., Schaarschmidt B. M., Schuermans A., Schumacher A. E., Schutte A. E., Schwebel D. C., Sedighi M., Seidu A. -A., Semnani F., Senapati S., Sengupta P., Senthilkumaran S., Sepanlou S. G., Sethi Y., Seyedi S. A., Seylani A., Shabany M., Shafeghat M., Shafie M., Shah P. A., Shahbandi A., Shahid I., Shahid S., Shahid W., Shahwan M. J., Shaikh M. A., Sham S., Shamim M. A., Shanawaz M., Sharfaei S., Sharifan A., Sharifi-Rad J., Sharma P., Sharma S., Sharma U., Sharma V., Sheikh A., Shiferaw D. S., Shigematsu M., Shin M. -J., Shiri R., Shishani K., Shittu A., Shiue I., Shivakumar K. M., Shrestha S., Shuval K., Sibhat M. M., Sigfusdottir I. D., Simpson C. R., Singh A., Singh J. A., Singh P., Singh R., Singh S., Siraj M. S., Skryabin V. Y., Skryabina A. A., Sleet D. A., Soleimani H., Solikhah S., Soliman S. S. M., Son J., Song S., Song Y., Soriano J. B., Spartalis M., Sreeramareddy C. T., Stafford L. K., Stark B. A., Steiropoulos P., Stortecky S., Abdulkader R. S., Sultana A., Sundstrom J., Swain C. K., Damavandi P. T., Tabatabaei S. M., Malazy O. T., Tabatabaeizadeh S. -A., Tabatabai S., Tabb K. M., Tabish M., Tabuchi T., Tadese F., Abkenar Y. T., Taiba J., Talaat I. M., Tampa M., Lukenze Tamuzi J. J. L., Tan K. -K., Tang H., Tarkang E. E., Tat N. Y., Tavangar S. M., Tehrani H., Teimoori M., Temsah M. -H., Hani Temsah R. M., Teramoto M., Thangaraju P., Thankappan K. R., Thapa R., Thapar R., Thavamani A., Thayakaran R., Thomas N. K., Tian J., Tichopad A., Tillawi T., Tonelli M., Topor-Madry R., Touvier M., Tovani-Palone M. R., Tran J. T., Tran N. M., Van Tran P., Trihandini I., Tripathi A., Tromans S. J., Truong V. T., Tri Tai Truyen T. T., Tsatsakis A., Tsegay G. M., Tsermpini E. E., Tumurkhuu M., Tung K., Ubah C. S., Udoakang A. J., Udoh A., Ullah A., Ullah S., Umair M., Umar T. P., Unim B., Unnikrishnan B., Upadhyay E., Usman J. S., Vahabi S. M., Vaithinathan A. G., Valizadeh R., Van den Eynde J., Varga O., Varma S. A., Vart P., Varthya S. B., Vasankari T. J., Vellingiri B., Vervoort D., Villafane J. H., Violante F. S., Viskadourou M., Volovat S. R., Vos T., Vujcic I. S., Wafa H. A., Wahab F., Wang C., Wang F., Wang N., Wang S., Wang Y., Wang Y. -P., Wei M. Y., Werdecker A., Wickramasinghe N. D., Wijeratne T., Wilandika A., Wilson S., Wolfe C. D. A., Wongsin U., Wu Z., Xiao H., Xu S., Xu X., Yadav L., Yano Y., Yaribeygi H., Yasufuku Y., Nia I. Y., Ye P., Yesuf S. A., Yezli S., Yigit A., Yigit V., Yilma M. T., Yon D. K., Yonemoto N., Yousefi Z., Yperzeele L., Yu C., Yunusa I., Zafari N., Tajrishi F. Z., Zakham F., Zastrozhin M. S., Zeineddine M. A., Zemedikun D. T., Zeng Y., Zhai C., Zhang C., Zhang H., Zhang L., Zhang N., Zhang Y., Zhao H., Zheng P., Zhong C., Zhou S., Zhu B., Zhu L., Zielinska M., Zikarg Y. T., Zmaili M., Zoeckler L. Z., Zou Z., Zumla A., Zweck E., and Zyoud S. H.
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- 2023
31. An Expert Opinion on the Role of the Rosuvastatin/Amlodipine Single Pill Fixed Dose Combination in Cardiovascular Prevention
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Giovanna Gallo, Riccardo Sarzani, Arrigo Francesco Giuseppe Cicero, Stefano Genovese, Matteo Pirro, Luca Gallelli, Andrea Faggiano, and Massimo Volpe
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Rosuvastatin/Amlodipine ,Cardiovascular prevention ,Dyslipidaemia ,Hypertension ,Fixed dose combination ,Internal Medicine ,Cardiology and Cardiovascular Medicine - Published
- 2023
32. Relationships between diuretic-related hyperuricemia and cardiovascular events: data from the URic acid Right for heArt Health study
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Maloberti, Alessandro, Bombelli, Michele, Facchetti, Rita, Barbagallo, Carlo Maria, Bernardino, Bruno, Rosei, Enrico Agabiti, Casiglia, Edoardo, Giuseppe Cicero, Arrigo Francesco, Cirillo, Massimo, Cirillo, Pietro, Desideri, Giovambattista, D’elia, Lanfranco, Dell’Oro, Raffaella, Ferri, Claudio, Galletti, Ferruccio, Giannattasio, Cristina, Loreto, Gesualdo, Iaccarino, Guido, Lippa, Luciano, Mallamaci, Francesca, Masi, Stefano, Mazza, Alberto, Muiesan, Maria Lorenza, Nazzaro, Pietro, Parati, Gianfranco, Palatini, Paolo, Pauletto, Paolo, Pontremoli, Roberto, Quarti-Trevano, Fosca, Rattazzi, Marcello, Rivasi, Giulia, Salvetti, Massimo, Tikhonoff, Valerie, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, Virdis, Agostino, Grassi, Guido, and Borghi, Claudio
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- 2020
- Full Text
- View/download PDF
33. Reduced-dose of doublet chemotherapy combined with anti-EGFR antibodies in vulnerable older patients with metastatic colorectal cancer: Data from the REVOLT study
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Emanuela Dell'Aquila, Chiara Carlomagno, Carmine Pinto, Giorgio Reggiardo, Domenico Corsi, Alfredo Colombo, Gerardo Rosati, Giuseppe Cicero, Domenico Bilancia, Antonio Avallone, Giuseppe Aprile, Stefania Rapisardi, Marika Cinausero, Silvia Brugnatelli, Rosati, Gerardo, Corsi, Domenico, Avallone, Antonio, Brugnatelli, Silvia, Dell'Aquila, Emanuela, Cinausero, Marika, Aprile, Giuseppe, Cicero, Giuseppe, Carlomagno, Chiara, Colombo, Alfredo, Rapisardi, Stefania, Pinto, Carmine, Reggiardo, Giorgio, Bilancia, Domenico, and Gerardo Rosati, Domenico Corsi, Antonio Avallone, Silvia Brugnatelli, Emanuela Dell'Aquila, Marika Cinausero, Giuseppe Aprile, Giuseppe Cicero, Chiara Carlomagno, Alfredo Colombo, Stefania Rapisardi, Carmine Pinto, Giorgio Reggiardo, Domenico Bilancia
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medicine.medical_specialty ,Reduced dose ,Colorectal cancer ,Leucovorin ,Cetuximab ,Neutropenia ,Gastroenterology ,FOLFOX ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Clinical endpoint ,Humans ,Panitumumab ,Doublet chemotherapy ,Anti-EGFR ,Aged ,Metastatic colorectal cancer ,Rectal Neoplasms ,business.industry ,Anti-EGFRs Doublet chemotherapy Metastatic colorectal cancer Reduced doses Vulnerable older patients ,Exanthema ,medicine.disease ,Rash ,Vulnerable older patients ,Oncology ,Colonic Neoplasms ,FOLFIRI ,Fluorouracil ,Geriatrics and Gerontology ,medicine.symptom ,Colorectal Neoplasms ,business ,medicine.drug - Abstract
Objectives To assess the toxicity patterns and effectiveness of doublet chemotherapy when administered at reduced doses of 20% (FOLFOX or FOLFIRI) in combination with anti-EGFR antibodies (cetuximab or panitumumab) in old, vulnerable patients with metastatic colorectal cancer (mCRC). Patients and methods We performed a retrospective observational study of RAS and BRAF wild-type, vulnerable patients aged ≥70 years with previously untreated mCRC. The primary endpoint was safety, and secondary endpoints were overall response rate (ORR), progression-free survival (PFS), and overall survival (OS). Results One hundred and eighteen patients were collected from 14 selected Italian centres. The median age was 75 (range, 70–85). Geriatric screening by G8 tool gave a score ≤ 14 in all patients. In total, 75 and 43 patients received FOLFOX or FOLFIRI, respectively, in combination with panitumumab (53%) or cetuximab (47%). The overall incidence of grade (G) 3–4 neutropenia was 11.8%, and for skin rash 11%. The most frequent adverse events were G1–2 skin rash (49.1%), G1–2 diarrhea (21.1%) and G1–2 nausea (17.7%). The ORR was 57.3%. Stable disease was observed in 29.1% of patients, with a disease control rate of 86.4%. With a median follow-up of 18 months, the median PFS was 10.0 months (95% confidence interval [CI]: 8.5–11.4), while the median OS was 18.0 months (95% CI: 16.0–19.9). No statistically significant difference was observed between the regimens in terms of ORR, PFS (p = 0.908), and OS (p = 0.832). Conclusion This study shows that with an appropriate design, including reduced doses, vulnerable older patients best tolerate chemotherapy when combined with anti-EGFR antibodies.
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- 2022
34. Uric Acid and Hypertension: a Review of Evidence and Future Perspectives for the Management of Cardiovascular Risk
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Claudio Borghi, Davide Agnoletti, Arrigo Francesco Giuseppe Cicero, Empar Lurbe, and Agostino Virdis
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Adolescent ,Cardiovascular Diseases ,Heart Disease Risk Factors ,Risk Factors ,Hypertension ,Internal Medicine ,Animals ,Humans ,Hyperuricemia ,Uric Acid - Abstract
Uric acid is the final product of purine metabolism, and its increased serum levels have been directly involved in the pathogenesis and natural history of hypertension. The relationship between elevated uric acid and hypertension has been proven in both animals and humans, and its relevance is already evident in childhood and adolescent population. The mechanism responsible for blood pressure increase in hyperuricemic subjects is implicating both oxidative stress and intracellular urate activity with a primary involvement of XOR (xanthine-oxidoreductase activity). An increase in the relative risk of hypertension has been confirmed by genetic data and by large meta-analyses of epidemiological data. The effects of urate-lowering treatment on blood pressure control in patients with elevated serum uric acid has been investigated in a small number of reliable studies with a large heterogeneity of patient populations and study designs. However, 2 large meta-analyses suggest a significant effect of urate-lowering treatment on blood pressure, thus confirming the significant relationship between high serum urate and blood pressure. The future research should be focused on a more appropriate identification of patients with cardiovascular hyperuricemia by considering the correct cardiovascular threshold of serum urate, the time-course of uricemia fluctuations, and the identification of reliable markers of urate overproduction that could significantly clarify the clinical and therapeutic implications of the interaction between serum uric acid and hypertension.
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- 2022
35. Supplementary Figures 1-4, Tables 1-2 from Targeting Human γδ T Cells with Zoledronate and Interleukin-2 for Immunotherapy of Hormone-Refractory Prostate Cancer
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Adrian C. Hayday, Matthias Eberl, Alfredo Salerno, Nicola Gebbia, Matilde D'Asaro, Simona Buccheri, Andrew Roberts, Giuseppe Cicero, Serena Meraviglia, Nadia Caccamo, Fabio Fulfaro, David Vermijlen, and Francesco Dieli
- Abstract
Supplementary Figures 1-4, Tables 1-2 from Targeting Human γδ T Cells with Zoledronate and Interleukin-2 for Immunotherapy of Hormone-Refractory Prostate Cancer
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- 2023
36. Data from Targeting Human γδ T Cells with Zoledronate and Interleukin-2 for Immunotherapy of Hormone-Refractory Prostate Cancer
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Adrian C. Hayday, Matthias Eberl, Alfredo Salerno, Nicola Gebbia, Matilde D'Asaro, Simona Buccheri, Andrew Roberts, Giuseppe Cicero, Serena Meraviglia, Nadia Caccamo, Fabio Fulfaro, David Vermijlen, and Francesco Dieli
- Abstract
The increasing evidence that γδ T cells have potent antitumor activity suggests their value in immunotherapy, particularly in areas of unmet need such as metastatic carcinoma. To this end, we initiated a phase I clinical trial in metastatic hormone-refractory prostate cancer to examine the feasibility and consequences of using the γδ T-cell agonist zoledronate, either alone or in combination with low-dose interleukin 2 (IL-2), to activate peripheral blood γδ cells. Nine patients were enlisted to each arm. Neither treatment showed appreciable toxicity. Most patients were treated with zoledronate + IL-2, but conversely only two treated with zoledronate displayed a significant long-term shift of peripheral γδ cells toward an activated effector-memory–like state (TEM), producing IFN-γ and perforin. These patients also maintained serum levels of tumor necrosis factor–related apoptosis inducing ligand (TRAIL), consistent with a parallel microarray analysis showing that TRAIL is produced by γδ cells activated via the T-cell receptor and IL-2. Moreover, the numbers of TEM γδ cells showed a statistically significant correlation with declining prostate-specific antigen levels and objective clinical outcomes that comprised three instances of partial remission and five of stable disease. By contrast, most patients treated only with zoledronate failed to sustain either γδ cell numbers or serum TRAIL, and showed progressive clinical deterioration. Thus, zoledronate + IL-2 represents a novel, safe, and feasible approach to induce immunologic and clinical responses in patients with metastatic carcinomas, potentially providing a substantially increased window for specific approaches to be administered. Moreover, γδ cell phenotypes and possibly serum TRAIL may constitute novel biomarkers of prognosis upon therapy with zoledronate + IL-2 in metastatic carcinoma. [Cancer Res 2007;67(15):7450–7]
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- 2023
37. Natural Course of COVID-19 and Independent Predictors of Mortality
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Luana Orlando, Gianluca Bagnato, Carmelo Ioppolo, Maria Stella Franzè, Maria Perticone, Antonio Giovanni Versace, Angela Sciacqua, Vincenzo Russo, Arrigo Francesco Giuseppe Cicero, Alberta De Gaetano, Giuseppe Dattilo, Federica Fogacci, Maria Concetta Tringali, Pierpaolo Di Micco, Giovanni Squadrito, and Egidio Imbalzano
- Subjects
Medicine (miscellaneous) ,NT-pro-BNP ,prothrombin time ,PaO2/FiO2 ,COVID-19 ,biomarkers ,SARS-CoV-2 ,coronavirus disease ,General Biochemistry, Genetics and Molecular Biology - Abstract
Background: During the SARS-CoV-2 pandemic, several biomarkers were shown to be helpful in determining the prognosis of COVID-19 patients. The aim of our study was to evaluate the prognostic value of N-terminal pro-Brain Natriuretic Peptide (NT-pro-BNP) in a cohort of patients with COVID-19. Methods: One-hundred and seven patients admitted to the Covid Hospital of Messina University between June 2022 and January 2023 were enrolled in our study. The demographic, clinical, biochemical, instrumental, and therapeutic parameters were recorded. The primary outcome was in-hospital mortality. A comparison between patients who recovered and were discharged and those who died during the hospitalization was performed. The independent parameters associated with in-hospital death were assessed by multivariable analysis and a stepwise regression logistic model. Results: A total of 27 events with an in-hospital mortality rate of 25.2% occurred during our study. Those who died during hospitalization were older, with lower GCS and PaO2/FiO2 ratio, elevated D-dimer values, INR, creatinine values and shorter PT (prothrombin time). They had an increased frequency of diagnosis of heart failure (p < 0.0001) and higher NT-pro-BNP values. A multivariate logistic regression analysis showed that higher NT-pro-BNP values and lower PT and PaO2/FiO2 at admission were independent predictors of mortality during hospitalization. Conclusions: This study shows that NT-pro-BNP levels, PT, and PaO2/FiO2 ratio are independently associated with in-hospital mortality in subjects with COVID-19 pneumonia. Further longitudinal studies are warranted to confirm the results of this study.
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- 2023
- Full Text
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38. Nutraceutical approaches to non-alcoholic fatty liver disease (NAFLD): A position paper from the International Lipid Expert Panel (ILEP)
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Manfredi Rizzo, Alessandro Colletti, Peter E. Penson, Niki Katsiki, Dimitri P. Mikhailidis, Peter P. Toth, Ioanna Gouni-Berthold, John Mancini, David Marais, Patrick Moriarty, Massimiliano Ruscica, Amirhossein Sahebkar, Dragos Vinereanu, Arrigo Francesco Giuseppe Cicero, Maciej Banach, Julio Acosta, Mutaz Al-Khnifsawi, Fahad Alnouri, Fahma Amar, Atanas G. Atanasov, Gani Bajraktari, Sonu Bhaskar, Agata Bielecka-Dąbrowa, Bojko Bjelakovic, Eric Bruckert, Ibadete Bytyçi, Alberto Cafferata, Richard Ceska, Arrigo F.G. Cicero, Krzysztof Chlebus, Xavier Collet, Magdalena Daccord, Olivier Descamps, Dragan Djuric, Ronen Durst, Marat V. Ezhov, Zlatko Fras, Dan Gaita, Adrian V. Hernandez, Steven R. Jones, Jacek Jozwiak, Nona Kakauridze, Amani Kallel, Amit Khera, Karam Kostner, Raimondas Kubilius, Gustavs Latkovskis, G.B. John Mancini, A. David Marais, Seth S. Martin, Julio Acosta Martinez, Mohsen Mazidi, Erkin Mirrakhimov, Andre R. Miserez, Olena Mitchenko, Natalya P. Mitkovskaya, Patrick M. Moriarty, Seyed Mohammad Nabavi, Devaki Nair, Demosthenes B. Panagiotakos, György Paragh, Daniel Pella, Zaneta Petrulioniene, Matteo Pirro, Arman Postadzhiyan, Raman Puri, Ashraf Reda, Željko Reiner, Dina Radenkovic, Michał Rakowski, Jemaa Riadh, Dimitri Richter, Maria-Corina Serban, Abdullah M.A Shehab, Aleksandr B. Shek, Cesare R. Sirtori, Claudia Stefanutti, Tomasz Tomasik, Margus Viigimaa, Pedro Valdivielso, Branislav Vohnout, Stephan von Haehling, Michal Vrablik, Nathan D. Wong, Hung-I Yeh, Jiang Zhisheng, and Andreas Zirlik
- Subjects
Pharmacology ,Settore MED/04 - Patologia Generale ,NAFLD ,Liver steatosis ,Position paper ,Dietary supplements ,Nutraceuticals - Abstract
Non-Alcoholic Fatty Liver Disease (NAFLD) is a common condition affecting around 10–25% of the general adult population, 15% of children, and even > 50% of individuals who have type 2 diabetes mellitus. It is a major cause of liver-related morbidity, and cardiovascular (CV) mortality is a common cause of death. In addition to being the initial step of irreversible alterations of the liver parenchyma causing cirrhosis, about 1/6 of those who develop NASH are at risk also developing CV disease (CVD). More recently the acronym MAFLD (Metabolic Associated Fatty Liver Disease) has been preferred by many European and US specialists, providing a clearer message on the metabolic etiology of the disease. The suggestions for the management of NAFLD are like those recommended by guidelines for CVD prevention. In this context, the general approach is to prescribe physical activity and dietary changes the effect weight loss. Lifestyle change in the NAFLD patient has been supplemented in some by the use of nutraceuticals, but the evidence based for these remains uncertain. The aim of this Position Paper was to summarize the clinical evidence relating to the effect of nutraceuticals on NAFLD-related parameters. Our reading of the data is that whilst many nutraceuticals have been studied in relation to NAFLD, none have sufficient evidence to recommend their routine use; robust trials are required to appropriately address efficacy and safety.
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- 2023
39. An Update on the Role of Anti-EGFR in the Treatment of Older Patients with Metastatic Colorectal Cancer
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Gerardo Rosati, Michele Montrone, Carmen Pacilio, Alfredo Colombo, Giuseppe Cicero, Fernando Paragliola, Angelo Vaia, Luigi Annunziata, Domenico Bilancia, and Gerardo Rosati, Michele Montrone, Carmen Pacilio, Alfredo Colombo, Giuseppe Cicero, Fernando Paragliola, Angelo Vaia, Luigi Annunziata, Domenico Bilancia
- Subjects
older patient ,metastatic colorectal cancer ,cetuximab ,panitumumab ,General Medicine - Abstract
Although colorectal cancer is increasingly being diagnosed in older patients, their number is largely underrepresented in phase II or III clinical trials. Consequently, guidelines and the SIOG recommendations are not sufficiently clear regarding the treatment of these patients, particularly when chemotherapy is combined with monoclonal antibodies (bevacizumab, cetuximab, and panitumumab). Targeted therapy based on the use of anti-epidermal growth factor receptors (EGFRs) is conditioned by the potential for increased toxicity, making it more difficult to treat an older, rat sarcoma virus (RAS) and B rapidly accelerated fibrosarcoma (BRAF) wild-type patient. In light of a more detailed characterization of the older population, modernly differentiable between fit, vulnerable, or frail patients on the basis of the comprehensive geriatric assessment, and of the analysis of more recent studies, this review fully collects data from the literature, differentiating the results on functional status patients.
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- 2022
40. Optimizing the Choice for Adjuvant Chemotherapy in Gastric Cancer
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Antonino Grassadonia, Antonella De Luca, Erminia Carletti, Patrizia Vici, Francesca Sofia Di Lisa, Lorena Filomeno, Giuseppe Cicero, Laura De Lellis, Serena Veschi, Rosalba Florio, Davide Brocco, Saverio Alberti, Alessandro Cama, Nicola Tinari, and Antonino Grassadonia, Antonella De Luca, Erminia Carletti, Patrizia Vici, Francesca Sofia Di Lisa, Lorena Filomeno, Giuseppe Cicero, Laura De Lellis, Serena Veschi, Rosalba Florio, Davide Brocco, Saverio Alberti, Alessandro Cama, Nicola Tinari
- Subjects
adjuvant chemotherapy ,predictive factor ,Cancer Research ,Oncology ,gastric cancer ,prognostic factors - Abstract
Advances in the management of gastric cancer have improved patient survival in the last decade. Nonetheless, the number of patients relapsing and dying after a diagnosis of localized gastric cancer is still too high, even in early stages (10% in stage I). Adjuvant systemic chemotherapy has been proven to significantly improve outcomes. In the present article we have critically reviewed the clinical trials that guide the current clinical practice in the adjuvant treatment of patients affected by resectable gastric cancer, focusing on the different approaches worldwide, i.e., adjuvant chemotherapy, adjuvant chemoradiotherapy, and perioperative chemotherapy. We also delineate the clinical–pathological characteristics that are commonly taken into account to identify patients at a higher risk of recurrence and requiring adjuvant chemotherapy, and also describe novel biomarkers and therapeutic agents that might allow personalization of the treatment.
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- 2022
41. CT-urography: a nationwide survey by the Italian Board of Urogenital Radiology
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Giorgio Ascenti, Giuseppe Cicero, Elena Bertelli, Maurizio Papa, Francesco Gentili, Vincenzo Ciccone, Rosa Manetta, Nicoletta Gandolfo, Gianpiero Cardone, and Vittorio Miele
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Contrast Media ,Humans ,Urography ,Radiology, Nuclear Medicine and imaging ,General Medicine ,Radiology ,Tomography, X-Ray Computed ,Urinary Tract - Abstract
Computed tomography-urography is currently the imaging modality of choice for the assessment of the whole urinary tract, giving the possibility to detect and characterize benign and malignant conditions. In particular, computed tomography-urography takes advantage from an improved visualization of the urinary collecting system due to acquisition of delayed scan obtained after excretion of intravenous contrast medium from the kidneys. Nevertheless, the remaining scans are of great help for identification, characterization, and staging of urological tumors. Considering the high number of diseases, urinary segment potentially involved and patients' features, scanning protocols of computed tomography-urography largely vary from one clinical case to another as well as selection and previous preparation of the patient. According to the supramentioned considerations, radiation exposure is also of particular concern. Italian radiologists were asked to express their opinions about computed tomography-urography performance and about its role in their daily practice through an online survey. This paper collects and summarizes the results.
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- 2022
42. Serum Uric Acid, Vascular Aging, and Endocrine Comorbidities
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Giuseppe Cicero, Arrigo Francesco, primary and Hu, Yijun, additional
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- 2023
- Full Text
- View/download PDF
43. DWI ratios: New indexes for Crohn’s disease activity at magnetic resonance enterography?
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Giuseppe Cicero, Angela Alibrandi, Alfredo Blandino, Velio Ascenti, Walter Fries, Anna Viola, and Silvio Mazziotti
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Radiology, Nuclear Medicine and imaging ,General Medicine - Published
- 2022
44. A case of liver injury during lipid‐lowering therapy
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Davide Agnoletti, Federica Fogacci, Antonio Di Micoli, Claudio Borghi, and Arrigo Francesco Giuseppe Cicero
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Pharmacology - Published
- 2022
45. Mimicking conditions of intestinal Crohn’s disease: magnetic resonance enterography findings
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Silvio Mazziotti, Christian Booz, Alfredo Blandino, Tommaso D'Angelo, Giuseppe Cicero, Thomas J. Vogl, and Giorgio Ascenti
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Crohn's disease ,medicine.medical_specialty ,Magnetic Resonance Spectroscopy ,medicine.diagnostic_test ,business.industry ,Intestinal Neoplasm ,medicine.medical_treatment ,Magnetic resonance imaging ,Disease ,medicine.disease ,Magnetic resonance enterography ,Magnetic Resonance Imaging ,Crohn’s disease ,Inflammatory bowel diseases ,Intestinal inflammation ,Intestinal neoplasms ,Magnetic Resonance Enterography ,Endoscopy ,Intestines ,Radiation therapy ,Crohn Disease ,Intestine, Small ,Biopsy ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Radiology ,business - Abstract
Crohn's disease is a chronic inflammatory condition characterized by a transmural involvement of intestinal walls. Its diagnosis comes from a combination of clinical data, imaging findings and, above all, endoscopy with biopsy results, which are mandatory for achieving a definitive diagnosis. Even so, endoscopy information may be unavailable, for instance due to technical impairments or patient intolerance. On the radiological side, Magnetic Resonance Enterography is currently considered the imaging technique of choice for Crohn's disease assessment, either at first diagnosis or follow-up. Nevertheless, the lack of radiation exposure as well as invasiveness has made this imaging approach suitable also for the evaluation of a number of small and large bowel diseases over recent years. However, it is important to remember that Magnetic Resonance Imaging findings are non-specific and that a wide overlap exists among Crohn's disease and other intestinal conditions. The aim of this work was to provide a series of intestinal affections evaluated through Magnetic Resonance Enterography that resemble Crohn's disease and that can be helpful in avoiding misinterpretation, especially when endoscopy data are missing.
- Published
- 2021
46. Diagnosis of Giant Cell Tumor of the Tendon Sheath Using Multiecho Gradient-Echo Sequence: the 'Superblooming Artifact'
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Michele Gaeta, Alfredo Blandino, Gabriele Cervino, Luca Fiorillo, Fabio Minutoli, Giuseppe Cicero, Sergio Vinci, and Marco Cicciù
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030222 orthopedics ,Artifact (error) ,Article Subject ,General Immunology and Microbiology ,medicine.diagnostic_test ,business.industry ,Mean age ,Magnetic resonance imaging ,General Medicine ,medicine.disease ,General Biochemistry, Genetics and Molecular Biology ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Giant-cell tumor of the tendon sheath ,0302 clinical medicine ,Hemosiderin ,Medicine ,business ,Nuclear medicine ,Sequence (medicine) ,Gradient echo - Abstract
Giant cell tumor of the tendon sheath is a tumor, which affects mainly the hands of people aged 30 to 50 years with a female prevalence. Magnetic resonance imaging (MRI) is essential for diagnosis and treatment planning. The aim of this study is to evaluate the efficacy of multiecho gradient-echoes (MeGE) sequence in detecting hemosiderin which is the hallmark of this tumor. MRIs were performed in a sample of 11 patients with a mean age of 45. With the proposed protocol, all readers were able to detect the susceptibility artifacts due to the presence of hemosiderin. MeGE sequence allows to highlight the presence of hemosiderin, and the use of 3 echo times (ET) (8, 16, and 24 ms) is suggested.
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- 2021
47. Incremental diagnostic value of color-coded virtual non-calcium dual-energy CT for the assessment of traumatic bone marrow edema of the scaphoid
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Christian Booz, Thomas J. Vogl, Marco Cavallaro, Tommaso D'Angelo, Felix C. Müller, Vitali Koch, Lukas Lenga, Ibrahim Yel, Christoph Mader, Moritz H. Albrecht, Giuseppe Cicero, Silvio Mazziotti, Kasper Kjærulf Gosvig, Julian L. Wichmann, and Simon S. Martin
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Adult ,Male ,medicine.medical_specialty ,Wrist ,Sensitivity and Specificity ,030218 nuclear medicine & medical imaging ,Multidetector computed tomography ,Young Adult ,03 medical and health sciences ,Magnetic resonance imaging ,0302 clinical medicine ,Bone Marrow ,Hounsfield scale ,Scaphoid ,medicine ,Edema ,Humans ,Radiology, Nuclear Medicine and imaging ,Aged ,Retrospective Studies ,Neuroradiology ,Aged, 80 and over ,Scaphoid Bone ,medicine.diagnostic_test ,Receiver operating characteristic ,business.industry ,Ultrasound ,Interventional radiology ,Retrospective cohort study ,General Medicine ,Middle Aged ,Fracture ,medicine.anatomical_structure ,Bone marrow edema ,030220 oncology & carcinogenesis ,Calcium ,Female ,Radiology ,Tomography, X-Ray Computed ,business - Abstract
To investigate the diagnostic accuracy of color-coded dual-energy CT virtual non-calcium (VNCa) reconstructions for the assessment of bone marrow edema (BME) of the scaphoid in patients with acute wrist trauma. Our retrospective study included data from 141 patients (67 women, 74 men; mean age 43 years, range 19–80 years) with acute wrist trauma who had undergone third-generation dual-source dual-energy CT and 3-T MRI within 7 days. Eight weeks after assessment of conventional grayscale dual-energy CT scans for the presence of fractures, corresponding color-coded VNCa reconstructions were independently analyzed by the same six radiologists for the presence of BME. CT numbers on VNCa reconstructions were evaluated by a seventh radiologist. Consensus reading of MRI series by two additional radiologists served as the reference standard. MRI depicted 103 scaphoideal zones with BME in 76 patients. On qualitative analysis, VNCa images yielded high overall sensitivity (580/618 [94%]), specificity (1880/1920 [98%]), and accuracy (2460/2538 [97%]) for assessing BME as compared with MRI as reference standard. The interobserver agreement was excellent (κ = 0.98). CT numbers derived from VNCa images were significantly different in zones with and without edema (p
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- 2021
48. Vitamin D Supplementation and COVID-19 Outcomes: Mounting Evidence and Fewer Doubts
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Arrigo Francesco Giuseppe Cicero, CLAUDIO BORGHI, Federica Fogacci, and Cicero AFG, Fogacci F, Borghi C
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Nutrition and Dietetics ,SARS-CoV-2 ,Dietary Supplements ,mortality ,Humans ,COVID-19 ,Vitamins ,Vitamin D ,Vitamin D Deficiency ,Food Science ,Cholecalciferol ,immune function - Abstract
The coronavirus disease 2019 (COVID-19) has already killed more than 6 million people around the world. A growing body of epidemiological evidence suggests that low 25-hydroxy vitamin D (25-OH-vitamin D) plasma levels are associated with an increased risk of developing COVID-19 and —most importantly—with a higher risk of developing more severe COVID-19 and dying. On the other hand, vitamin D supplementation during the early phases of COVID-19 has been related to a decreased length of hospital stay, less frequent need for oxygen, and a reduced mortality rate in inpatients. This seems to be particularly true when high dosages are used. In light of this evidence, further studies are needed to define the best timing for vitamin D supplementation and the most effective dosage schedule.
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- 2022
49. Inter-reader agreement of the Prostate Imaging Quality (PI-QUAL) score: A bicentric study
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Rossano Girometti, Alfredo Blandino, Clara Zichichi, Giuseppe Cicero, Lorenzo Cereser, Maria De Martino, Miriam Isola, Chiara Zuiani, Vincenzo Ficarra, Claudio Valotto, Michele Bertolotto, Gianluca Giannarini, Girometti, Rossano, Blandino, Alfredo, Zichichi, Clara, Cicero, Giuseppe, Cereser, Lorenzo, De Martino, Maria, Isola, Miriam, Zuiani, Chiara, Ficarra, Vincenzo, Valotto, Claudio, Bertolotto, Michele, and Giannarini, Gianluca
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Male ,Prostate ,Reproducibility of Results ,Reproducibility of Result ,Prostatic Neoplasms ,General Medicine ,Multiparametric Magnetic Resonance Imaging ,Prostatic neoplasms ,Magnetic Resonance Imaging ,Retrospective Studie ,Humans ,Radiology, Nuclear Medicine and imaging ,Retrospective Studies ,Prostatic neoplasm ,Human - Abstract
Purpose: To investigate the inter-reader agreement of the Prostate imaging quality (PI-QUAL) for multiparametric magnetic resonance imaging (mpMRI).Methods: We included 66 men who underwent 1.5 T mpMRI in June 2020-July 2020 in center 1, with no exclusion criteria. mpMRI included multiplanar T2-weighted imaging (T2WI), Diffusion-weighted imaging (DWI), and dynamic contrast-enhanced imaging (DCE). Two readers from center 2 (experience < 1000 to > 1500 examinations), blinded to clinical history but not to acquisition parameters, independently assessed PI-QUAL qualitative/anatomical items of each mpMRI sequence, final PI-QUAL score (1-5), and the Prostate imaging reporting and data system version 2.1 (PI-RADSv2.1) category of the index lesion. Cohen's kappa statistics (k) or prevalence-adjusted-bias-adjusted kappa (PABAK) were used to calculate the inter-reader agreement in assessing the PI-QUAL (1-to-5 scale and 1-2 versus 3 versus 4-5), the diagnostic quality of each mpMRI sequence, qualitative/anatomical items, and PI-RADSv2.1 category.Results: The inter-reader agreement for PI-QUAL category was moderate upon 1-5 scale (k = 0.55; 95%CI 0.39-0.71) or 1-3 scale (k = 0.51; 95%CI 0.29-0.72), with 90.9% examinations categorized PI-QUAL > 3 by readers. The agreement in assessing a sequence as diagnostic was higher for T2WI (k = 0.76) than DCE (PABAK = 0.61) and DWI (k = 0.46), ranging moderate-to-substantial for most of the items. Readers provided comparable PI-RADSv2.1 categorization (k = 0.88 [excellent agreement]; 95%CI 0.81-0.96), with most PI-RADSv2.1 > 3 assignments found in PI-QUAL > 3 examinations (43/46 by reader 1, and 47/47 by reader 2).Conclusions: The reproducibility of PI-QUAL was moderate. Higher PI-QUAL scores were associated with excellent inter-reader agreement for PI-RADSv2.1 categorization.
- Published
- 2022
50. MR-Enterography Pitfalls
- Author
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Giuseppe Cicero, Tommaso D’Angelo, Giorgio Ascenti, and Silvio Mazziotti
- Published
- 2022
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