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1. Clinical presentation and prognosis of COVID-19 in older adults with hypothyroidism: data from the GeroCovid observational study

Author

Bagala, V, Sala, A, Trevisan, C, Okoye, C, Incalzi, R, Monzani, F, Volpato, S, Antognoli, R, Antonietti, M, Bandini, G, Bellelli, G, Benvenuti, E, Bergamin, M, Bertolotti, M, Biagini, C, Bianchetti, A, Bianchi, A, Bianchi, M, Bignamini, S, Blandini, D, Boffelli, S, Bugada, M, Calsolaro, V, Calvani, D, Carpagnano, E, Carrieri, B, Castaldo, V, Cavarape, A, Cazzulani, I, Celesti, C, Ceolin, C, Ceresini, M, Cherubini, A, Chizzoli, A, Ciarrocchi, E, Cicciomessere, P, Coin, A, Corsi, A, Custodero, C, D'Agostino, F, D'Errico, M, De Iorio, A, De Marchi, A, Desideri, G, Di Matteo, E, Espinosa, E, Esposito, L, Fazio, C, Filippini, C, Fiore, L, Fontana, C, Forte, L, Montorzi, R, Fumagalli, C, Fumagalli, S, Gareri, P, Giordano, A, Giuliani, E, Greco, A, Herbst, A, Ielo, G, La Marca, A, Porta, U, Lazzari, I, Lelli, D, Longobucco, Y, Lucchini, F, Lucente, D, Maestri, L, Maggio, M, Mainqua, P, Marengoni, A, Martin, B, Massa, V, Mazza, L, Mazzoccoli, C, Mossello, E, Morellini, F, Mussi, C, Orio, G, Paglia, A, Pelagalli, G, Pelizzoni, L, Picci, A, Ranhoff, A, Remelli, F, Resta, O, Riccardi, A, Rinaldi, D, Rozzini, R, Sabba, C, Sacco, L, Santoliquido, M, Savino, M, Scarso, F, Sergi, G, Serviddio, G, Sidoli, C, Solfrizzi, V, Soli, B, Tafaro, L, Tedde, A, Testa, G, Tinti, M, Tonarelli, F, Tonon, E, Vitali, A, Zoccarato, F, Zotti, S, Bagala V., Sala A., Trevisan C., Okoye C., Incalzi R. A., Monzani F., Volpato S., Antognoli R., Antonietti M. P., Bandini G., Bellelli G., Benvenuti E., Bergamin M., Bertolotti M., Biagini C. A., Bianchetti A., Bianchi A., Bianchi M., Bignamini S., Blandini D., Boffelli S., Bugada M., Calsolaro V., Calvani D., Carpagnano E., Carrieri B., Castaldo V., Cavarape A., Cazzulani I., Celesti C., Ceolin C., Ceresini M. G., Cherubini A., Chizzoli A., Ciarrocchi E., Cicciomessere P., Coin A., Corsi A., Custodero C., D'Agostino F., D'Errico M. M., De Iorio A., De Marchi A., Desideri G., Di Matteo E., Espinosa E., Esposito L., Fazio C., Filippini C., Fiore L., Fontana C., Forte L., Montorzi R. F., Fumagalli C., Fumagalli S., Gareri P., Giordano A., Giuliani E., Greco A., Herbst A., Ielo G., La Marca A., Porta U., Lazzari I., Lelli D., Longobucco Y., Lucchini F., Lucente D., Maestri L., Maggio M., Mainqua P., Marengoni A., Martin B., Massa V., Mazza L., Mazzoccoli C., Mossello E., Morellini F., Mussi C., Orio G., Paglia A., Pelagalli G., Pelizzoni L., Picci A., Ranhoff A. H., Remelli F., Resta O., Riccardi A., Rinaldi D., Rozzini R., Sabba C., Sacco L., Santoliquido M., Savino M., Scarso F., Sergi G., Serviddio G., Sidoli C., Solfrizzi V., Soli B., Tafaro L., Tedde A., Testa G. D., Tinti M. G., Tonarelli F., Tonon E., Vitali A., Zoccarato F., Zotti S., Bagala, V, Sala, A, Trevisan, C, Okoye, C, Incalzi, R, Monzani, F, Volpato, S, Antognoli, R, Antonietti, M, Bandini, G, Bellelli, G, Benvenuti, E, Bergamin, M, Bertolotti, M, Biagini, C, Bianchetti, A, Bianchi, A, Bianchi, M, Bignamini, S, Blandini, D, Boffelli, S, Bugada, M, Calsolaro, V, Calvani, D, Carpagnano, E, Carrieri, B, Castaldo, V, Cavarape, A, Cazzulani, I, Celesti, C, Ceolin, C, Ceresini, M, Cherubini, A, Chizzoli, A, Ciarrocchi, E, Cicciomessere, P, Coin, A, Corsi, A, Custodero, C, D'Agostino, F, D'Errico, M, De Iorio, A, De Marchi, A, Desideri, G, Di Matteo, E, Espinosa, E, Esposito, L, Fazio, C, Filippini, C, Fiore, L, Fontana, C, Forte, L, Montorzi, R, Fumagalli, C, Fumagalli, S, Gareri, P, Giordano, A, Giuliani, E, Greco, A, Herbst, A, Ielo, G, La Marca, A, Porta, U, Lazzari, I, Lelli, D, Longobucco, Y, Lucchini, F, Lucente, D, Maestri, L, Maggio, M, Mainqua, P, Marengoni, A, Martin, B, Massa, V, Mazza, L, Mazzoccoli, C, Mossello, E, Morellini, F, Mussi, C, Orio, G, Paglia, A, Pelagalli, G, Pelizzoni, L, Picci, A, Ranhoff, A, Remelli, F, Resta, O, Riccardi, A, Rinaldi, D, Rozzini, R, Sabba, C, Sacco, L, Santoliquido, M, Savino, M, Scarso, F, Sergi, G, Serviddio, G, Sidoli, C, Solfrizzi, V, Soli, B, Tafaro, L, Tedde, A, Testa, G, Tinti, M, Tonarelli, F, Tonon, E, Vitali, A, Zoccarato, F, Zotti, S, Bagala V., Sala A., Trevisan C., Okoye C., Incalzi R. A., Monzani F., Volpato S., Antognoli R., Antonietti M. P., Bandini G., Bellelli G., Benvenuti E., Bergamin M., Bertolotti M., Biagini C. A., Bianchetti A., Bianchi A., Bianchi M., Bignamini S., Blandini D., Boffelli S., Bugada M., Calsolaro V., Calvani D., Carpagnano E., Carrieri B., Castaldo V., Cavarape A., Cazzulani I., Celesti C., Ceolin C., Ceresini M. G., Cherubini A., Chizzoli A., Ciarrocchi E., Cicciomessere P., Coin A., Corsi A., Custodero C., D'Agostino F., D'Errico M. M., De Iorio A., De Marchi A., Desideri G., Di Matteo E., Espinosa E., Esposito L., Fazio C., Filippini C., Fiore L., Fontana C., Forte L., Montorzi R. F., Fumagalli C., Fumagalli S., Gareri P., Giordano A., Giuliani E., Greco A., Herbst A., Ielo G., La Marca A., Porta U., Lazzari I., Lelli D., Longobucco Y., Lucchini F., Lucente D., Maestri L., Maggio M., Mainqua P., Marengoni A., Martin B., Massa V., Mazza L., Mazzoccoli C., Mossello E., Morellini F., Mussi C., Orio G., Paglia A., Pelagalli G., Pelizzoni L., Picci A., Ranhoff A. H., Remelli F., Resta O., Riccardi A., Rinaldi D., Rozzini R., Sabba C., Sacco L., Santoliquido M., Savino M., Scarso F., Sergi G., Serviddio G., Sidoli C., Solfrizzi V., Soli B., Tafaro L., Tedde A., Testa G. D., Tinti M. G., Tonarelli F., Tonon E., Vitali A., Zoccarato F., and Zotti S.

Abstract

Background: The prevalence of hypothyroidism among older patients hospitalized for COVID-19 and its association with mortality is unclear. This study aims to investigate the prevalence of hypothyroidism in older COVID-19 inpatients and verify if this comorbidity is associated with a specific pattern of onset symptoms and a worse prognosis. Methods: COVID-19 inpatients aged ≥ 60 years, participating in the GeroCovid acute wards cohort, were included. The history of hypothyroidism was derived from medical records and the use of thyroid hormones. Sociodemographic data, comorbidities, symptoms/signs at the disease onset and inflammatory markers at ward admission were compared between people with vs without history of hypothyroidism. The association between hypothyroidism and in-hospital mortality was tested through Cox regression. Results: Of the 1245 patients included, 8.5% had a history of hypothyroidism. These patients were more likely to present arterial hypertension and obesity compared with those without an history of hypothyroidism. Concerning COVID-19 clinical presentation, patients with hypothyroidism had less frequently low oxygen saturation and anorexia but reported muscle pain and loss of smell more commonly than those without hypothyroidism. Among the inflammatory markers, patients with hypothyroidism had higher lymphocytes values. At Cox regression, hypothyroidism was associated with reduced in-hospital mortality only in the univariable model (HR = 0.66, 95% CI 0.45–0.96, p = 0.03); conversely, no significant result were observed after adjusting for potential confounders (HR = 0.69, 95% CI 0.47–1.03, p = 0.07). Conclusions: Hypothyroidism does not seem to substantially influence the prognosis of COVID-19 in older people, although it may be associated with peculiar clinical and biochemical features at the disease onset.

Published
2023

2. Clinical profile of trazodone users in a multisetting older population: data from the Italian GeroCovid Observational study

Author

Coin, A, Noale, M, Gareri, P, Trevisan, C, Bellio, A, Fini, F, Abbatecola, A, Del Signore, S, Malara, A, Mossello, E, Fumagalli, S, Volpato, S, Monzani, F, Bellelli, G, Zia, G, Incalzi, R, Andrieri, D, Antognoli, R, Antonietti, M, Bagalà, V, Bandini, G, Bazzano, S, Bellotti, F, Benvenuti, E, Bergamin, M, Bertolotti, M, Biagini, C, Bianchetti, A, Bianchi, A, Bianchi, M, Bianchi, P, Biasin, F, Bignamini, S, Blandini, D, Boffelli, S, Bontempi, C, Bordignon, A, Bracchitta, L, Bugada, M, Cafariello, C, Caleri, V, Calsolaro, V, Calvani, D, Campagna, F, Capasso, A, Capurso, S, Carino, S, Carpagnano, E, Carrieri, B, Castaldo, V, Castelli, M, Castellino, M, Cavarape, A, Cazzulani, I, Celesti, C, Ceolin, C, Ceresini, M, Ceretti, A, Cherubini, A, Chizzoli, A, Ciarrocchi, E, Cicciomessere, P, Colombo, M, Corsi, A, Crispino, A, Cucunato, R, Custodero, C, D’Agostino, F, D’Errico, M, D’Amico, F, De Iorio, A, De Marchi, A, Dell’Armi, A, Delmonte, M, Desideri, G, Devita, M, Di Matteo, E, Espinosa, E, Esposito, L, Fazio, C, Ferro, C, Filippini, C, Fiore, L, Fiorillo, S, Fontana, C, Forte, L, Montorzi, R, Fumagalli, C, Gasbarri, P, Giordano, A, Giuliani, E, Granata, R, Coin A., Noale M., Gareri P., Trevisan C., Bellio A., Fini F., Abbatecola A. M., Del Signore S., Malara A., Mossello E., Fumagalli S., Volpato S., Monzani F., Bellelli G., Zia G., Incalzi R. A., Andrieri D., Antognoli R., Antonietti M. P., Bagalà V., Bandini G., Bazzano S., Bellotti F., Benvenuti E., Bergamin M., Bertolotti M., Biagini C. A., Bianchetti A., Bianchi A., Bianchi M., Bianchi P., Biasin F., Bignamini S., Blandini D., Boffelli S., Bontempi C., Bordignon A., Bracchitta L. M., Bugada M., Cafariello C., Caleri V., Calsolaro V., Calvani D., Campagna F. A., Capasso A., Capurso S., Carino S., Carpagnano E., Carrieri B., Castaldo V., Castelli M., Castellino M., Cavarape A., Cazzulani I., Celesti C., Ceolin C., Ceresini M. G., Ceretti A., Cherubini A., Chizzoli A., Ciarrocchi E., Cicciomessere P., Colombo M., Corsi A., Crispino A., Cucunato R., Custodero C., D’Agostino F., D’Errico M. M., D’Amico F., De Iorio A., De Marchi A., Dell’Armi A., Delmonte M., Desideri G., Devita M., Di Matteo E., Espinosa E., Esposito L., Fazio C., Ferro C., Filippini C., Fiore L., Fiorillo S., Fontana C., Forte L., Montorzi R. F., Fumagalli C., Gasbarri P. P., Giordano A., Giuliani E., Granata R., Coin, A, Noale, M, Gareri, P, Trevisan, C, Bellio, A, Fini, F, Abbatecola, A, Del Signore, S, Malara, A, Mossello, E, Fumagalli, S, Volpato, S, Monzani, F, Bellelli, G, Zia, G, Incalzi, R, Andrieri, D, Antognoli, R, Antonietti, M, Bagalà, V, Bandini, G, Bazzano, S, Bellotti, F, Benvenuti, E, Bergamin, M, Bertolotti, M, Biagini, C, Bianchetti, A, Bianchi, A, Bianchi, M, Bianchi, P, Biasin, F, Bignamini, S, Blandini, D, Boffelli, S, Bontempi, C, Bordignon, A, Bracchitta, L, Bugada, M, Cafariello, C, Caleri, V, Calsolaro, V, Calvani, D, Campagna, F, Capasso, A, Capurso, S, Carino, S, Carpagnano, E, Carrieri, B, Castaldo, V, Castelli, M, Castellino, M, Cavarape, A, Cazzulani, I, Celesti, C, Ceolin, C, Ceresini, M, Ceretti, A, Cherubini, A, Chizzoli, A, Ciarrocchi, E, Cicciomessere, P, Colombo, M, Corsi, A, Crispino, A, Cucunato, R, Custodero, C, D’Agostino, F, D’Errico, M, D’Amico, F, De Iorio, A, De Marchi, A, Dell’Armi, A, Delmonte, M, Desideri, G, Devita, M, Di Matteo, E, Espinosa, E, Esposito, L, Fazio, C, Ferro, C, Filippini, C, Fiore, L, Fiorillo, S, Fontana, C, Forte, L, Montorzi, R, Fumagalli, C, Gasbarri, P, Giordano, A, Giuliani, E, Granata, R, Coin A., Noale M., Gareri P., Trevisan C., Bellio A., Fini F., Abbatecola A. M., Del Signore S., Malara A., Mossello E., Fumagalli S., Volpato S., Monzani F., Bellelli G., Zia G., Incalzi R. A., Andrieri D., Antognoli R., Antonietti M. P., Bagalà V., Bandini G., Bazzano S., Bellotti F., Benvenuti E., Bergamin M., Bertolotti M., Biagini C. A., Bianchetti A., Bianchi A., Bianchi M., Bianchi P., Biasin F., Bignamini S., Blandini D., Boffelli S., Bontempi C., Bordignon A., Bracchitta L. M., Bugada M., Cafariello C., Caleri V., Calsolaro V., Calvani D., Campagna F. A., Capasso A., Capurso S., Carino S., Carpagnano E., Carrieri B., Castaldo V., Castelli M., Castellino M., Cavarape A., Cazzulani I., Celesti C., Ceolin C., Ceresini M. G., Ceretti A., Cherubini A., Chizzoli A., Ciarrocchi E., Cicciomessere P., Colombo M., Corsi A., Crispino A., Cucunato R., Custodero C., D’Agostino F., D’Errico M. M., D’Amico F., De Iorio A., De Marchi A., Dell’Armi A., Delmonte M., Desideri G., Devita M., Di Matteo E., Espinosa E., Esposito L., Fazio C., Ferro C., Filippini C., Fiore L., Fiorillo S., Fontana C., Forte L., Montorzi R. F., Fumagalli C., Gasbarri P. P., Giordano A., Giuliani E., and Granata R.

Abstract

Background and objectives: Depression is highly prevalent in older adults, especially in those with dementia. Trazodone, an antidepressant, has shown to be effective in older patients with moderate anxiolytic and hypnotic activity; and a common off-label use is rising for managing behavioral and psychological symptoms of dementia (BPSD). The aim of the study is to comparatively assess the clinical profiles of older patients treated with trazodone or other antidepressants. Methods: This cross-sectional study involved adults aged ≥ 60 years at risk of or affected with COVID-19 enrolled in the GeroCovid Observational study from acute wards, geriatric and dementia-specific outpatient clinics, as well as long-term care facilities (LTCF). Participants were grouped according to the use of trazodone, other antidepressants, or no antidepressant use. Results: Of the 3396 study participants (mean age 80.6 ± 9.1 years; 57.1% females), 10.8% used trazodone and 8.5% others antidepressants. Individuals treated with trazodone were older, more functionally dependent, and had a higher prevalence of dementia and BPSD than those using other antidepressants or no antidepressant use. Logistic regression analyses found that the presence of BPSD was associated with trazodone use (odds ratio (OR) 28.4, 95% confidence interval (CI) 18-44.7 for the outcome trazodone vs no antidepressants use, among participants without depression; OR 2.17, 95% CI 1.05-4.49 for the outcome trazodone vs no antidepressants use, among participants with depression). A cluster analysis of trazodone use identified three clusters: cluster 1 included mainly women, living at home with assistance, multimorbidity, dementia, BPSD, and depression; cluster 2 included mainly institutionalized women, with disabilities, depression, and dementia; cluster 3 included mostly men, often living at home unassisted, with better mobility performance, fewer chronic diseases, dementia, BPSD, and depression. Discussion: The use of trazodo

Published
2023

4. Clinical profile of trazodone users in a multisetting older population: data from the Italian GeroCovid Observational study

Author

Coin A., Noale M., Gareri P., Trevisan C., Bellio A., Fini F., Abbatecola A. M., Del Signore S., Malara A., Mossello E., Fumagalli S., Volpato S., Monzani F., Bellelli G., Zia G., Incalzi R. A., Andrieri D., Antognoli R., Antonietti M. P., Bagalà V., Bandini G., Bazzano S., Bellotti F., Benvenuti E., Bergamin M., Bertolotti M., Biagini C. A., Bianchetti A., Bianchi A., Bianchi M., Bianchi P., Biasin F., Bignamini S., Blandini D., Boffelli S., Bontempi C., Bordignon A., Bracchitta L. M., Bugada M., Cafariello C., Caleri V., Calsolaro V., Calvani D., Campagna F. A., Capasso A., Capurso S., Carino S., Carpagnano E., Carrieri B., Castaldo V., Castelli M., Castellino M., Cavarape A., Cazzulani I., Celesti C., Ceolin C., Ceresini M. G., Ceretti A., Cherubini A., Chizzoli A., Ciarrocchi E., Cicciomessere P., Colombo M., Corsi A., Crispino A., Cucunato R., Custodero C., D’Agostino F., D’Errico M. M., D’Amico F., De Iorio A., De Marchi A., Dell’Armi A., Delmonte M., Desideri G., Devita M., Di Matteo E., Espinosa E., Esposito L., Fazio C., Ferro C., Filippini C., Fiore L., Fiorillo S., Fontana C., Forte L., Montorzi R. F., Fumagalli C., Gasbarri P. P., Giordano A., Giuliani E., Granata R., Coin, A, Noale, M, Gareri, P, Trevisan, C, Bellio, A, Fini, F, Abbatecola, A, Del Signore, S, Malara, A, Mossello, E, Fumagalli, S, Volpato, S, Monzani, F, Bellelli, G, Zia, G, Incalzi, R, Andrieri, D, Antognoli, R, Antonietti, M, Bagalà, V, Bandini, G, Bazzano, S, Bellotti, F, Benvenuti, E, Bergamin, M, Bertolotti, M, Biagini, C, Bianchetti, A, Bianchi, A, Bianchi, M, Bianchi, P, Biasin, F, Bignamini, S, Blandini, D, Boffelli, S, Bontempi, C, Bordignon, A, Bracchitta, L, Bugada, M, Cafariello, C, Caleri, V, Calsolaro, V, Calvani, D, Campagna, F, Capasso, A, Capurso, S, Carino, S, Carpagnano, E, Carrieri, B, Castaldo, V, Castelli, M, Castellino, M, Cavarape, A, Cazzulani, I, Celesti, C, Ceolin, C, Ceresini, M, Ceretti, A, Cherubini, A, Chizzoli, A, Ciarrocchi, E, Cicciomessere, P, Colombo, M, Corsi, A, Crispino, A, Cucunato, R, Custodero, C, D’Agostino, F, D’Errico, M, D’Amico, F, De Iorio, A, De Marchi, A, Dell’Armi, A, Delmonte, M, Desideri, G, Devita, M, Di Matteo, E, Espinosa, E, Esposito, L, Fazio, C, Ferro, C, Filippini, C, Fiore, L, Fiorillo, S, Fontana, C, Forte, L, Montorzi, R, Fumagalli, C, Gasbarri, P, Giordano, A, Giuliani, E, and Granata, R

Subjects
BPSD, Profile, Clinical characteristic, Depression, Trazodone, Dementia
Abstract

Background and objectives: Depression is highly prevalent in older adults, especially in those with dementia. Trazodone, an antidepressant, has shown to be effective in older patients with moderate anxiolytic and hypnotic activity; and a common off-label use is rising for managing behavioral and psychological symptoms of dementia (BPSD). The aim of the study is to comparatively assess the clinical profiles of older patients treated with trazodone or other antidepressants. Methods: This cross-sectional study involved adults aged ≥ 60 years at risk of or affected with COVID-19 enrolled in the GeroCovid Observational study from acute wards, geriatric and dementia-specific outpatient clinics, as well as long-term care facilities (LTCF). Participants were grouped according to the use of trazodone, other antidepressants, or no antidepressant use. Results: Of the 3396 study participants (mean age 80.6 ± 9.1 years; 57.1% females), 10.8% used trazodone and 8.5% others antidepressants. Individuals treated with trazodone were older, more functionally dependent, and had a higher prevalence of dementia and BPSD than those using other antidepressants or no antidepressant use. Logistic regression analyses found that the presence of BPSD was associated with trazodone use (odds ratio (OR) 28.4, 95% confidence interval (CI) 18-44.7 for the outcome trazodone vs no antidepressants use, among participants without depression; OR 2.17, 95% CI 1.05-4.49 for the outcome trazodone vs no antidepressants use, among participants with depression). A cluster analysis of trazodone use identified three clusters: cluster 1 included mainly women, living at home with assistance, multimorbidity, dementia, BPSD, and depression; cluster 2 included mainly institutionalized women, with disabilities, depression, and dementia; cluster 3 included mostly men, often living at home unassisted, with better mobility performance, fewer chronic diseases, dementia, BPSD, and depression. Discussion: The use of trazodone was highly prevalent in functionally dependent and comorbid older adults admitted to LTCF or living at home. Clinical conditions associated with its prescription included depression as well as BPSD.

Published
2023

5. Monkeypox: an Italian, multicenter study of 104 cases

Author

Maronese, C, Ramoni, S, Avallone, G, Giacalone, S, Quattri, E, Gaspari, V, Rapparini, L, Robuffo, S, Delmonte, S, Merli, M, Tutone, M, Facci, G, Carugno, A, Parietti, M, Latini, A, Giuliani, E, Sena, P, Ribero, S, Quaglino, P, Piraccini, B, Marzano, A, Maronese, Carlo Alberto, Ramoni, Stefano, Avallone, Gianluca, Giacalone, Serena, Quattri, Eleonora, Gaspari, Valeria, Rapparini, Luca, Robuffo, Silvia, Delmonte, Sergio, Merli, Martina, Tutone, Marco, Facci, Giulia, Carugno, Andrea, Parietti, Michele, Latini, Alessandra, Giuliani, Eugenia, Sena, Paolo, Ribero, Simone, Quaglino, Pietro, Piraccini, Bianca Maria, Marzano, Angelo Valerio, Maronese, C, Ramoni, S, Avallone, G, Giacalone, S, Quattri, E, Gaspari, V, Rapparini, L, Robuffo, S, Delmonte, S, Merli, M, Tutone, M, Facci, G, Carugno, A, Parietti, M, Latini, A, Giuliani, E, Sena, P, Ribero, S, Quaglino, P, Piraccini, B, Marzano, A, Maronese, Carlo Alberto, Ramoni, Stefano, Avallone, Gianluca, Giacalone, Serena, Quattri, Eleonora, Gaspari, Valeria, Rapparini, Luca, Robuffo, Silvia, Delmonte, Sergio, Merli, Martina, Tutone, Marco, Facci, Giulia, Carugno, Andrea, Parietti, Michele, Latini, Alessandra, Giuliani, Eugenia, Sena, Paolo, Ribero, Simone, Quaglino, Pietro, Piraccini, Bianca Maria, and Marzano, Angelo Valerio

Published
2023

10. List of contributors

Author

Akaike, Toshihiro, primary, Ben-Nissan, B., additional, Cho, Chong-Su, additional, Choi, Yun-Jaie, additional, Colliec-Jouault, S., additional, Giuliani, E., additional, Jiang, Tao, additional, Kim, S.-K., additional, Lowe, B., additional, Müller, Werner E.G., additional, Parravicini, R., additional, Parravicini, V., additional, Reis, R.L., additional, Schröder, Heinz C., additional, Şenel, S., additional, Sharma, C.P., additional, Silva, T.H., additional, Singh, Bijay, additional, Venkatesan, J., additional, Victor, S.P., additional, and Wang, Xiaohong, additional

Published
2015
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15. The ocular effects of erythropoietin

Author

Twersky, Laura H., Generoso, August J., Flores, Wendy, and Giuliani, E. Regina

Subjects
Eye diseases -- Risk factors -- Development and progression -- Care and treatment, Erythropoietin -- Physiological aspects -- Health aspects, Neovascularization -- Physiological aspects, Science and technology
Abstract

ABTRACT: Erythropoietin (EPO) is a hormone with hematopoietic functions, controlling red blood cell production in response to hypoxia. It stimulates erythropoiesis by preventing apoptosis of erythrocyte progenitors. In addition to [...]

Published
2010

16. From the Aosta Valley to Sicily: Differences in Clinico-Pathologic Features and Distribution of Risk Factors in Italian Melanoma Patients: A Multicenter Survey from the GIPME: P-013

Author

Fava, P., Crocetti, E., Pimpinelli, N., Chiarugi, A., Fargnoli, M. C., Maurichi, A., Rubegni, P., Manganoni, M. A., Bottoni, U., Catricalá, C., Cavicchini, S., Santinami, M., Alaibac, M., Annetta, A., Astrua, C., Borghi, A., Bressy, S., Calzavara Pinton, P., Capizzi, R., Clerico, R., Colombo, E., Corradin, M. T., De Simone, P., Fantini, F., Ferreli, C., Filosa, G., Girgenti, V., Giuliani, E., Guarneri, C., Lamberti, A., Lisi, P., Nardini, P., Papini, M., Peris, K., Pizzichetta, M. A., Salvini, C., Savoia, P., Strippoli, D., Tolomio, E., Tomassini, M. A., Vena, G. A., Zichichi, L., and Quaglino, P.

Published
2013

17. Features of fragile people with SARS-CoV-2 infection in isolation in a COVID-19 hotel in Rome, Italy.

Author

STINGONE, C., LATINI, A., GIANSERRA, L., SALVI, M., DONÀ, M. G., GIULIANI, E., LA PAROLA, I. LESNONI, MUSSI, A., CAMELI, N., GARELLI, V., GIULIANI, M., BUONOMINI, A. R., VUJOVIC, B., CERIMELE, M., and MORRONE, A.

Abstract

OBJECTIVE: Temporary COVID-19 hotels have been established in Italy to assist the homeless people that test positive for SARSCoV-2 and require isolation. This observational study aimed to investigate the characteristics of the subjects who were isolated at the Casa tra Noi COVID-19 hotel in Rome between October 2020 and May 2021 and to estimate the duration of SARSCoV-2 positivity according to their main socio-demographic, behavioural and clinical features. SUBJECTS AND METHODS: Socio-demographic data, clinical history, and anamnestic data of guests were collected by the clinicians reviewing the medical documentation and face-to-face interviewing. Nasopharyngeal swabs were performed every 7 days and the presence of SARS-CoV-2 was assessed by RT-PCR. Median duration of SARSCoV-2 positivity according to socio-demographic, behavioral factors and clinical condition was calculated. RESULTS: The 196 guests (161 males, 82.1%) had a median age of 41 years (IQR: 30-53), and were mostly African (87, 44.4%). Only asymptomatic/paucisymptomatic infections were observed. Almost half of the individuals (84, 42.9%) were affected by at least one co-morbidity, the frequency of which was higher among women (57.1% vs. 39.8%, p=0.06). The date of the negative SARS-CoV-2 molecular test was known for 144 guests (73.5%). Among these, the median duration of positivity was 21 days (IQR: 14-26) and did not significantly vary with age, country of origin, smoking status, alcohol or drug abuse. Among the co-morbidities, only infectious diseases significantly modified the duration of positivity, which increased from 21 to 34 days (p=0.013). CONCLUSIONS: Hotel guests were frequently affected by physical/mental co-morbidities. Duration of SARS-CoV-2 positivity was significantly prolonged only in individuals affected by an infectious disease. [ABSTRACT FROM AUTHOR]

Published
2022

22. Special issue on business conduct and human rights in global value chains

Author

Karin Buhmann, Taylor, M., and Giuliani, E.

Subjects
Human rights, media_common.quotation_subject, 05 social sciences, 010501 environmental sciences, 01 natural sciences, General Business, Management and Accounting, Market economy, 0502 economics and business, Value (economics), Business, Economic system, 050203 business & management, 0105 earth and related environmental sciences, media_common
Published
2017
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29. Propofol: a safe anaesthetic drug in experimental cardiac surgery in rabbits

Author

Giuliani, E., Manenti, A., Barbieri, A., Farinetti, A., and Anna Vittoria Mattioli

Subjects
Male, Midazolam, Hemodynamics, Arrhythmias, Cardiac, Myocardial Reperfusion Injury, Mesenchymal Stem Cell Transplantation, Species Specificity, Adrenergic alpha-2 Receptor Agonists, Anesthesia, Intravenous, Bradycardia, Animals, Hypnotics and Sedatives, Drug Interactions, Rabbits, Cardiac Surgical Procedures, Intraoperative Complications, Propofol, Anesthetics, Intravenous
Abstract

Experimental surgery needs a pharmacological approach that can interfere with cardiac function.In a animal model of regenerative medicine of myocardium we use an anaesthesiological protocol that included Propofol, a benzodiazepine (Midazolam) and an alpha-2 adrenergic agent.In a group of 15 rabbits undergoing cardiac surgery we reported 1 arrhythmic complication during stem cell injection.The functional cardio- respiratory depressor activity of Propofol was compensated by alpha-2 adrenergic drugs, avoiding serious complications. We hypothesize that the functional cardio-respiratory depressor of different anaesthesiological drugs can be reversed by the contemporary administration of with adrenergic agents.Arrhythmias, Cardiac ischemia, Cardiovascular toxicity, Propofol.La chirurgia sperimentale richiede un approccio farmacologico che può interferire con la funzione cardiaca.In un modello animale di chirurgia rigenerativa del miocardio abbiamo utilizzato un protocollo anestesiologico che includeva Propofol, una benzodiazepina (Midazolam) e un alfa2-adrenergico.In un gruppo di 15 conigli sottoposti a chirurgia cardiaca abbiamo osservato 1 complicanza aritmica letale durante la somministrazione intramiocardica di cellule staminali. DISCUSSIONE. L’azione di depressione della funzione cardio respiratoria del Propofol è stata compensate da farmaci con attività alfa2-adrenergica che hanno ridotto notevolmente le complicanze aritmiche. Ipotizziamo che l’azione di depressione della funzionalità cardio respiratoria di farmaci anestesiologici utilizzati nella chirurgia sperimentale cardiaca nel coniglio possa essere controllata dalla somministrazione contemporanea di agenti adrenergici.

Published
2018

37. Gestational age of pregnancy loss in women with unexplained recurrent miscarriage

Author

Ticconi, C, Giuliani, E, Sorge, Rp, Patrizi, L, Piccione, E, and Pietropolli, A

Subjects
Adult, Abortion, Habitual, obstetrics, recurrent pregnancy loss, epidemiology and statistics, obstetric complications, pregnancy loss, Pregnancy, Humans, Settore MED/40 - Ginecologia e Ostetricia, Female, Gestational Age
Abstract

The aim of this study was to investigate the gestational age (GA) of pregnancy loss in women with unexplained recurrent miscarriage (RM) and to determine whether the miscarriages occur at similar GA in RM women.This retrospective study was carried out in a university hospital and included 288 women with unexplained RM. The GA at which each miscarriage occurred was carefully determined. Overall, 739 miscarriages were analyzed.RM women had miscarriages at a median GA of 7 weeks (range: 3-20). In RM women, 47.2% (n = 136) experienced miscarriages within a 1-week range of GA and 53.4% (n = 154) had miscarriages in the same period of fetal development (pre-embryonic, embryonic or fetal).Women with unexplained RM tend to have miscarriages at the same GA, which is characteristic for each patient.

Published
2015

38. Local innovation and global value chains in developing countries

Author

De Marchi, V., Giuliani, E., Rabellotti, R., RS: UNU-MERIT Theme 3, and RS: UNU-MERIT Theme 1

Abstract

The GVC approach has stressed that inter-firm linkages within GVCs can play a crucial role in transferring technological knowledge and promoting innovation. However, the exact nature of these GVC inter-firms relationships, and their impact on the learning and innovative processes of firms involved in such GVCs in developing countries is still controversial and rather understudied. In this paper we argue that to investigate whether and how firms involved in GVCs (as well as industrial clusters, regions and countries) innovate, scholars should not focus entirely on GVC characteristics and the role of lead firms, but they also should take into account domestic technological capabilities at the firm, industrial cluster/regional and local innovation system-levels. In this study we undertake a systematic review of the literature on GVCs in developing countries to investigate if and how innovation has been undertaken at the local level. With cluster analysis, we have identified three types of GVCs, defined as (a) GVC-led Innovators, consisting of innovative local firms, which intensively use knowledge sources from within the GVC; (b) Independent Innovators also consisting of innovative firms, but whose learning sources mainly come from outside the GVC; c) Weak Innovators, including a large group of scarcely innovative firms, drawing selectively on some of the knowledge sources available within the GVC but poorly using other forms of learning.

Published
2015

39. Stem Cells Transplantation in Myocardial Tissue Induces Pro-arrhythmic Effects and Promotes Reperfusion. Comparison between Intramyocardial and Intravenous Approach

Author

Manenti A, Mario Migaldi, Reggiani Bonetti L, Mattioli Av, A. Farinetti, Panini F, Pennella S, Lonardi R, and Giuliani E

Subjects
medicine.medical_specialty, business.industry, medicine.medical_treatment, Mesenchymal stem cell, Ischemia, medicine.disease, Transplantation, Route of administration, medicine.anatomical_structure, Internal medicine, medicine, Cardiology, Stem cell, business, Reperfusion injury, Saline, Artery
Abstract

Background: The aim of study was to evaluate the histologic changes and pro-arrhythmic features of intramyocardial stem cells transplantation after myocardial ischemia. Methods: In 21 New Zealand rabbits an ischemia/reperfusion injury was induced by temporary ligation of anterior coronary artery during cardiac surgical procedure. Mesenchymal bone marrow stem cells (BMSCs) were isolated, cultured and re-suspended for injection. BMSCs were injected at the peri-infarcted area and side effects were evaluated and correlated with histological changes. Ventricular premature contractions (VPCs) were recorded during surgery and after 7 and 21 days. Results: Frequent VPCs were observed before and after cells administration. The 7th day after the surgery, the episodes of VPC are more frequent in the group that received i.m. BMSCs and in the group that received i.m. administration of saline, compared to animals treated with BMSCs i.v. (135 ± 23; 52 ± 12; and 38 ± 9, respectively, P

Published
2014
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40. Plasminogen activator inhibitor-1, factor V, factor II and methylenetetrahydrofolate reductase polymorphisms in women with recurrent miscarriage

Author

Emilio Piccione, Lodovico Patrizi, Bruno, Adalgisa Pietropolli, Carlo Ticconi, and Giuliani E

Subjects
Adult, Abortion, Habitual, medicine.medical_specialty, Hyperhomocysteinemia, Case-Control Studies, Factor V, Female, Humans, Methylenetetrahydrofolate Reductase (NADPH2), Middle Aged, Plasminogen Activator Inhibitor 1, Polymorphism, Genetic, Pregnancy, Prothrombin, Thrombophilia, Gastroenterology, Loss of heterozygosity, chemistry.chemical_compound, Genetic, Internal medicine, Recurrent miscarriage, medicine, Factor V Leiden, Polymorphism, Gynecology, biology, business.industry, Abortion, Obstetrics and Gynecology, medicine.disease, Habitual, chemistry, Plasminogen activator inhibitor-1, Methylenetetrahydrofolate reductase, biology.protein, Settore MED/40 - Ginecologia e Ostetricia, business, Plasminogen activator
Abstract

The present study investigated the association between genetic polymorphisms of selected thrombophilic factors with recurrent miscarriage (RM). The genetic polymorphisms for plasminogen activator inhibitor-1 4G/5G (PAI-1), Factor V Leiden (FVL), Factor II G20210A (FII) and methylenetetrahydrofolate reductase MTHFR C677T were determined in 186 RM women and 129 healthy women. In RM women, the frequency of heterozygosity for PAI-1 5G/4G (31%) was significantly higher than in controls (5G/4G: 22%) whereas no difference was found in the case of homozygosity 4G/4G and 5G/5G. The frequencies of genotype G/A for FVL and FII were significantly higher in RM women (FVL, 10%; FII, 8%) than in controls (FVL, 3%; FII, 2%). No difference was found in the case of MTHFR C677T. The polymorphisms of FVL and FII should be screened in RM women, whereas PAI-1 seems to be weakly associated with RM. The role of MTHFR C677T polymorphisms without hyperhomocysteinemia appears negligible.

Published
2014

41. [OP.3C.02] LOOKING FOR THE OPTIMAL BLOOD PRESSURE VALUES IN OLD PEOPLE WITH COGNITIVE DECLINE

Author

Lorenzi, C., primary, Mossello, E., additional, Giuliani, E., additional, Nesti, N., additional, Bulgaresi, M., additional, Caleri, V., additional, Pieraccioli, M., additional, Tonon, E., additional, Cavallini, M.C., additional, Baroncini, C., additional, Di Bari, M., additional, Biagini, C.A., additional, Marchionni, N., additional, and Ungar, A., additional

Published
2016
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42. Clinical severity of ischemic stroke and neural damage biomarkers in the acute setting: the STROke MArkers (STROMA) study

Author

Barbieri, A., Giuliani, E., Carone, C., Pederzoli, F., Mascheroni, G., Greco, G., Stucchi, C., and Susanna Genedani

Subjects
Aged, 80 and over, Male, S100 Calcium Binding Protein beta Subunit, Severity of Illness Index, Peptide Fragments, Brain Ischemia, Fibrin Fibrinogen Degradation Products, Stroke, Biological markers, Fibrin fragment D, Matrix Metalloproteinase 9, Pro-brain natriuretic peptide (1-76), S-100 calcium-binding protein beta subunit, Acute Disease, Natriuretic Peptide, Brain, Humans, Female, Prospective Studies, Biomarkers, Aged
Abstract

Stroke is a leading cause of long-term morbidity and mortality affecting several hundred-thousand people annually in the Western Countries. Various panels of biomarkers of neural damage have been developed and validated. The primary objective of this investigation was to measure the correlation between the clinical severity of stroke and the serum/plasma concentrations of neural damage biomarkers.A prospective investigation was conducted on a panel of biomarkers composed of S100β, matrix metalloproteinase-9 (MMP-9), N-terminal pro-B-type natriuretic peptide (NT pro-BNP) and D-dimer at admission and after 24 hours, in a cohort patients with a confirmed diagnosis of stroke in an emergency setting (STROke-MArkers STROMA).A total of 58 consecutive patients were enrolled, no participant was excluded; according to clinical severity measured by National Institute of Health Stroke Scale (NIHSS) there were 29 minor strokes, 24 moderate, 3 moderate-severe, 2 severe. The Spearman's rank correlation test was used to assess the relationship between the baseline NIHSS value and the concentrations of the four biomarkers: all the studied biomarkers showed a statistically significant correlation with baseline NIHSS at 24 hours. A multivariate ordinal regression model was used to analyze the correlation of markers with stroke severity, stratified, according to NIHSS score: MMP-9 and S100β showed a statistically significant correlation after 24 hours.MMP-9, S100β, NT pro-BNP and D-dimer showed a good correlation with the clinical severity of stroke which may become an additional resource in the acute patient evaluation and potentially follow-up.

Published
2013

43. Thyroid autoimmunity and recurrent miscarriage

Author

Ticconi, C, Giuliani, E, Veglia, Manuela, Pietropolli, A, Piccione, E, and Di Simone, Nicoletta

Subjects
Adult, Abortion, Habitual, Thyroid Hormones, autoimmunity, Thyroid Gland, thyroid autoantibodies, Iodide Peroxidase, Thyroglobulin, recurrent miscarriage, Pregnancy, thyroid autoimmunity, Case-Control Studies, Humans, Female, Settore MED/40 - Ginecologia e Ostetricia, Autoantibodies
Abstract

To investigate the role of antithyroid autoantibodies (ATA) in recurrent miscarriage (RM).In this case-control study, a total of 160 women with RM and 100 healthy women were investigated for the presence of serum ATA directed against thyreoglobulin (TG-Ab), thyroid peroxidase (TPO-Ab) and TSH receptor (TSHr-Ab), which were determined by either chemiluminescence or radioimmunoassay.Antithyroid autoantibodies were detected in 46 (28.75%) women with RM and in 13 (13%) women of the control group (P0.05). The frequencies for TG-Ab and TPO-Ab were higher in RM than in control women. Among the women of RM group, 91.3% of ATA+ women were positive also for other autoantibodies. The majority of study women were euthyroid.Antithyroid autoantibodies, particularly TG-Ab, are associated with RM and could be an expression of a more general maternal immune system abnormality leading to RM. ATA could have a role in RM irrespective of thyroid hormone status.

Published
2011

44. Immobilization of lutetium bisphthalocyanine in nanostructured biomimetic sensors using the LbL technique for phenol detection

Author

Rodríguez Méndez, María Luz, Giuliani, E., Saja Sáez, José Antonio de, Zucolotto, V., C. Brazaca, Laís, and Ramos Fernandes, Edson Giuliani

Subjects
Materials science, Indoles, Metalloporphyrins, Inorganic chemistry, Biomedical Engineering, Biophysics, Catechols, chemistry.chemical_compound, Phenols, Biomimetic Materials, Limit of Detection, Electrochemistry, Polyamines, Voltammetry, Electrodes, Detection limit, Catechol, General Medicine, Electrochemical Techniques, Chronoamperometry, Amperometry, CATÁLISE (PROPRIEDADES), Nanostructures, chemistry, Linear range, Saturated calomel electrode, Electrode, Biotechnology
Abstract

Producción Científica, This study describes the development of amperometric sensors based on poly(allylamine hydrochloride) (PAH) and lutetium bisphthalocyanine (LuPc2) films assembled using the Layer-by-Layer (LbL) technique. The films have been used as modified electrodes for catechol quantification. Electrochemical measurements have been employed to investigate the catalytic properties of the LuPc2 immobilized in the LbL films. By chronoamperometry, the sensors present excellent sensitivity (20 nA μM−1) in a wide linear range (R2 = 0.994) up to 900 μM and limit of detection (s/n = 3) of 37.5 × 10−8 M for catechol. The sensors have good reproducibility and can be used at least for ten times. The work potential is +0.3 V vs. saturated calomel electrode (SCE). In voltammetry measurements, the calibration curve shows a good linearity (R2 = 0.992) in the range of catechol up to 500 μM with a sensitivity of 90 nA μM−1 and LD of 8 μM., 2022-07-6, 2022-07-06

Published
2011

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