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16 results on '"Giugni, Juan C."'

1. Cerliponase alfa in the treatment of patients with classic and atypical late infantile neuronal ceroid lipofuscinosis in Latin America

Author

Guelbert, Norberto, primary, Segura, Oscar M Espitia, additional, Amoretti, Carolina, additional, Arteaga, Angélica Arteaga, additional, Atanacio, Nora G, additional, Bazan, Natacha S, additional, Carvalho, Ellaine D.F, additional, de Andrade, María D. F Carvalho, additional, Denzler, Inés M, additional, Durand, Consuelo, additional, Ribeiro, Erlane M, additional, Giugni, Juan C, additional, González, Gabriel, additional, Moron, Dolores González, additional, Guelbert, Guillermo, additional, Rodriguez, Zulma J Hernández, additional, Embiruçu, Emilia K, additional, Kauffman, Marcelo A, additional, Mancilla, Nury I, additional, Marcon, Laureano, additional, Pereira, Alessandra Marques, additional, de Souza, Carolina F Fischinger Moura, additional, Muñoz, Victor A, additional, Florez, Ricardo A Naranjo, additional, Pessoa, André L, additional, Ruiz, Maria V, additional, Villareal, Martha M Solano, additional, Spécola, Norma, additional, Tavera, Lina M, additional, Tello, Javiera, additional, Schifferli, Mónica Troncoso, additional, Urgrina, Sonia, additional, Vaccarezza, María M, additional, Vergara, Diane, additional, and Villanueva, María M, additional

Published
2022
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3. Ventral Intermediate Nucleus Versus Zona Incerta Region Deep Brain Stimulation in Essential Tremor

Author

Eisinger, Robert S., primary, Wong, Joshua, additional, Almeida, Leonardo, additional, Ramirez-Zamora, Adolfo, additional, Cagle, Jackson N., additional, Giugni, Juan C., additional, Ahmed, Bilal, additional, Bona, Alberto R., additional, Monari, Erin, additional, Wagle Shukla, Aparna, additional, Hess, Christopher W., additional, Hilliard, Justin D., additional, Foote, Kelly D., additional, Gunduz, Aysegul, additional, Okun, Michael S., additional, and Martinez-Ramirez, Daniel, additional

Published
2017
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4. Holmes tremor

Author

Raina, Gabriela B., primary, Cersosimo, Maria G., additional, Folgar, Silvia S., additional, Giugni, Juan C., additional, Calandra, Cristian, additional, Paviolo, Juan P., additional, Tkachuk, Veronica A., additional, Zuñiga Ramirez, Carlos, additional, Tschopp, Andrea L., additional, Calvo, Daniela S., additional, Pellene, Luis A., additional, Uribe Roca, Marcela C., additional, Velez, Miriam, additional, Giannaula, Rolando J., additional, Fernandez Pardal, Manuel M., additional, and Micheli, Federico E., additional

Published
2016
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5. Ventral Intermediate Nucleus Versus Zona Incerta Region Deep Brain Stimulation in Essential Tremor.

Author

Eisinger, Robert S., Wong, Joshua, Almeida, Leonardo, Ramirez‐Zamora, Adolfo, Cagle, Jackson N., Giugni, Juan C., Ahmed, Bilal, Bona, Alberto R., Monari, Erin, Wagle Shukla, Aparna, Hess, Christopher W., Hilliard, Justin D., Foote, Kelly D., Gunduz, Aysegul, Okun, Michael S., and Martinez‐Ramirez, Daniel

Subjects
DEEP brain stimulation, VENTRAL hernia, ESSENTIAL tremor, NEUROSCIENCES, MEDICAL sciences
Abstract

Abstract: Background: The ventral intermediate nucleus (VIM) is the target of choice for Essential Tremor (ET) deep brain stimulation (DBS). Renewed interest in caudal zona incerta (cZI) stimulation for tremor control has recently emerged and some groups believe this approach may address long‐term reduction of benefit seen with VIM‐DBS. Objectives: To compare clinical outcomes and DBS programming in the long‐term between VIM and cZI neurostimulation in ET‐DBS patients. Materials and Methods: A retrospective review of 53 DBS leads from 47 patients was performed. Patients were classified into VIM or cZI groups according to the location of the activated DBS contact. Demographics, DBS settings, and Tremor Rating Scale scores were compared between groups at baseline and yearly follow‐up to 4 years after DBS. Student t‐tests and analysis of variance (ANOVA) were used to compare variables between groups. Results: Relative to baseline, an improvement in ON‐DBS tremor scores was observed in both groups from 6 months to 4 years post‐DBS (p < 0.05). Although improvement was still significant at 4 years, scores from month 6 to 2 years were comparable between groups but at 3 and 4 years post‐DBS the outcome was better in the VIM group (p < 0.01). Stimulation settings were similar across groups, although we found a lower voltage in the VIM group at 3 years post‐DBS. Conclusions: More ventral DBS contacts in the cZI region do improve tremor, however, VIM‐DBS provided better long‐term outcomes. Randomized controlled trials comparing cZI vs VIM targets should confirm these results. [ABSTRACT FROM AUTHOR]

Published
2018
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6. Association between antidepressants and falls in Parkinson’s disease

Author

Martinez-Ramirez, Daniel, primary, Giugni, Juan C., additional, Almeida, Leonardo, additional, Walz, Roger, additional, Ahmed, Bilal, additional, Chai, Fiona A., additional, Rundle-Gonzalez, Valerie, additional, Bona, Alberto R., additional, Monari, Erin, additional, Wagle Shukla, Aparna, additional, Hess, Christopher W., additional, Hass, Chris J., additional, and Okun, Michael S., additional

Published
2015
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7. Deep Brain Stimulation in a Case of Mitochondrial Disease

Author

Martinez-Ramirez, Daniel, primary, Hack, Nawaz, additional, Vasquez, Matthew L., additional, Morita, Hokuto, additional, Giugni, Juan C., additional, Wolf, Janine M., additional, Romrell, Janet, additional, Zeilman, Pamela R., additional, Hess, Christopher W., additional, Foote, Kelly D., additional, Okun, Michael S., additional, and Wagle Shukla, Aparna, additional

Published
2015
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8. Rate of aspiration pneumonia in hospitalized Parkinson’s disease patients: a cross-sectional study

Author

Martinez-Ramirez, Daniel, primary, Almeida, Leonardo, additional, Giugni, Juan C., additional, Ahmed, Bilal, additional, Higuchi, Masa-aki, additional, Little, Christopher S., additional, Chapman, John P., additional, Mignacca, Caroline, additional, Shukla, Aparna Wagle, additional, Hess, Christopher W., additional, Hegland, Karen Wheeler, additional, and Okun, Michael S., additional

Published
2015
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15. Holmes tremor: Clinical description, lesion localization, and treatment in a series of 29 cases.

Author

Raina, Gabriela B., Cersosimo, Maria G., Folgar, Silvia S., Giugni, Juan C., Calandra, Cristian, Paviolo, Juan P., Tkachuk, Veronica A., Ramirez, Carlos Zuñiga, Tschopp, Andrea L., Calvo, Daniela S., Pellene, Luis A., Roca, Marcela C. Uribe, Velez, Miriam, Giannaula, Rolando J., Pardal, Manuel M. Fernandez, Micheli, Federico E., Zuñiga Ramirez, Carlos, Uribe Roca, Marcela C, and Fernandez Pardal, Manuel M

Published
2016
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16. Deep Brain Stimulation in a Case of Mitochondrial Disease.

Author

Martinez‐Ramirez, Daniel, Hack, Nawaz, Vasquez, Matthew L., Morita, Hokuto, Giugni, Juan C., Wolf, Janine M., Romrell, Janet, Zeilman, Pamela R., Hess, Christopher W., Foote, Kelly D., Okun, Michael S., and Wagle Shukla, Aparna

Subjects
MITOCHONDRIAL pathology, DEEP brain stimulation, BRAIN stimulation, MOVEMENT disorder treatments, PARKINSON'S disease, DYSTONIA
Abstract

Background DBS has proven to be an effective therapy for Parkinson's disease, essential tremor, and primary dystonia. Mixed results have been reported in case series for other hyperkinetic disorders, and sparse data are available regarding secondary movement disorders. We report on the clinical effects of bilateral globus pallidus internus ( GPi) DBS, a progressive mitochondrial cytopathy. Methods A single patient with myoclonus and dystonia syndrome secondary to a mitochondrial cytopathy with history of perinatal hypoxia was identified from our University of Florida DBS database. Demographics, clinical, surgical, and DBS data were documented. Results At 6 months post- DBS, we observed a 32% (361 to 527) improvement on quality of life (36-item Medical Outcome Study Short-Form Health Survey; SF-36). Objective clinical scales revealed a 33% (143 to 96) improvement in the Unified Myoclonus Rating Scale ( UMRS) total score. The UMRS action myoclonus subsection revealed a 29% (69 to 46) improvement. No significant changes were observed in the Burke-Fahn-Mardsen Dystonia Rating Scale ( BFMDRS). After 1-year follow-up, a worsening of 59% (527 to 215) was observed in the SF-36 scale, of 19% (28.5 to 35) in the BFMDRS, and of 23% (96 to 124) in the UMRS. However, the frequency and intensity of action myoclonus scores remained lower when compared to baseline scores. Conclusions Although we observed a loss of benefit in the long term for most quality-of-life and clinical outcomes, the DBS effects on action myoclonus seemed to remain stable. Longer follow-up studies are necessary to confirm our short-term and unblinded findings. [ABSTRACT FROM AUTHOR]

Published
2016
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