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2. “Full-plastic jacket” with everolimus-eluting Absorb bioresorbable vascular scaffolds: Clinical outcomes in the multicenter prospective RAI registry (ClinicalTrials.gov Identifier: NCT02298413)

Author

Tarantini, Giuseppe, Masiero, Giulia, Fovino, Luca Nai, Mojoli, Marco, Varricchio, Attilio, Loi, Bruno, Gistri, Roberto, Misuraca, Leonardo, Gabrielli, Gabriele, Cortese, Bernardo, Pisano, Francesco, Moretti, Luciano, Tumminello, Gabriele, Olivari, Zoran, Mazzarotto, Pietro, Colombo, Alessandro, Calabrò, Paolo, Nicolino, Annamaria, Tellaroli, Paola, Corrado, Donatella, Durante, Alessandro, and Steffenino, Giuseppe

Published
2018
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3. Clinical findings after bioresorbable vascular scaffold implantation in an unrestricted cohort of patients with ST-segment elevation myocardial infarction (from the RAI registry)

Author

Moscarella, Elisabetta, Ielasi, Alfonso, Varricchio, Attilio, De Angelis, Maria Carmen, Loi, Bruno, Tarantini, Giuseppe, Calabrò, Paolo, Cortese, Bernardo, Mazzarotto, Pietro, Gabrielli, Gabriele, Pisano, Francesco, Facchin, Michela, Misuraca, Leonardo, Lucci, Valerio, Gistri, Roberto, Tumminello, Gabriele, Moretti, Luciano, Colombo, Alessandro, Durante, Alessandro, Fineschi, Massimo, Piraino, Davide, Ferrario, Maurizio, Coscarelli, Sebastian, Nicolino, Annamaria, Tespili, Maurizio, Corrado, Donatella, and Steffenino, Giuseppe

Published
2018
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4. Registro Absorb Italiano (BVS-RAI): an investigators-owned and -directed, open, prospective registry of consecutive patients treated with the Absorb™ BVS: study design

Author

Cortese, Bernardo, Ielasi, Alfonso, Varricchio, Attilio, Tarantini, Giuseppe, LaVecchia, Luigi, Pisano, Francesco, Facchin, Michela, Gistri, Roberto, D’Urbano, Maurizio, Lucci, Valerio, Loi, Bruno, Tumminello, Gabriele, Colombo, Alessandro, Limbruno, Ugo, Nicolino, Annamaria, Calzolari, Diego, Tognoni, Gianni, Defilippi, Gianfranco, Buccheri, Dario, Tespili, Maurizio, Corrado, Donatella, and Steffenino, Giuseppe

Published
2015
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5. Clinical outcomes of overlapping versus non‐overlapping everolimus‐eluting absorb bioresorbable vascular scaffolds: An analysis from the multicentre prospective RAI registry (ClinicalTrials.gov identifier: NCT02298413)

Author

Tarantini, Giuseppe, Mojoli, Marco, Masiero, Giulia, Cortese, Bernardo, Loi, Bruno, Varricchio, Attilio, Gabrielli, Gabriele, Durante, Alessandro, Pasquetto, Giampaolo, Calabrò, Paolo, Gistri, Roberto, Tumminello, Gabriele, Misuraca, Leonardo, Pisano, Francesco, Ielasi, Alfonso, Mazzarotto, Pietro, Coscarelli, Sebastian, Lucci, Valerio, Moretti, Luciano, Nicolino, Annamaria, Colombo, Alessandro, Olivari, Zoran, Fineschi, Massimo, Piraino, Davide, Piatti, Luigi, Canosi, Umberto, Tellaroli, Paola, Corrado, Donatella, Rovera, Chiara, and Steffenino, Giuseppe

Published
2018
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10. Coronary microvascular dysfunction and prognosis in hypertrophic cardiomyopathy

Author

Cecchi, Franco, Olivotto, Iacopo, Gistri, Roberto, Lorenzoni, Roberto, Chiriatti, Giampaolo, and Camici, Paolo G.

Subjects
Cardiomyopathy, Hypertrophic -- Prognosis, Dipyridamole -- Physiological aspects
Abstract

An infusion of the drug dipyridamole can identify patients with hypertrophic cardiomyopathy who have a poor prognosis, according to a study of 51 patients. Dipyridamole makes blood vessels relax, which normally causes blood flow to increase. If it does not, this is a sign that the patient has dysfunctional blood vessels. A PET scan can be used to measure blood flow through the coronary arteries while the patient receives dipyridamole.

Published
2003

18. TCT-425 Bioresorbable vascular scaffold technology for small vessel coronary artery disease: results from the Italian multicenter RAI Registry

Author

Masiero, Giulia, primary, Tarantini, Giuseppe, additional, Mojoli, Marco, additional, Loi, Bruno, additional, Cortese, Bernardo, additional, Varricchio, Attilio, additional, Ielasi, Alfonso, additional, Pisano, Francesco, additional, Mazzarotto, Pietro, additional, Calabro', Paolo, additional, Gistri, Roberto, additional, Durante, Alessandro, additional, Piraino, Davide, additional, Tumminello, Gabriele, additional, Lucci, Valerio, additional, Moretti, Luciano, additional, Misuraca, Leonardo, additional, Pasquetto, Giampaolo, additional, Colombo, Alessandro, additional, Ferrario, Maurizio, additional, Coscarelli, Sebastian, additional, Olivari, Zoran, additional, Nicolino, Annamaria, additional, Piatti, Luigi, additional, Tellaroli, Paola, additional, Corrado, Donatella, additional, and Steffenino, Giuseppe, additional

Published
2016
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19. TCT-408 Thirty-day Outcome Following Polymeric Bioresorbable Scaffold Implantation in 347 STEMI Patients Enrolled in the Multicenter “Registro Absorb Italiano” (RAI Registry)

Author

Ielasi, Alfonso, primary, Moscarella, Elisabetta, additional, Loi, Bruno, additional, Cortese, Bernardo, additional, Calabro', Paolo, additional, Tarantini, Giuseppe, additional, Gistri, Roberto, additional, Pisano, Francesco, additional, Mazzarotto, Pietro, additional, Gabrielli, Gabriele, additional, Pasquetto, Giampaolo, additional, Misuraca, Leonardo, additional, Lucci, Valerio, additional, Tumminello, Gabriele, additional, Moretti, Luciano, additional, Ferrario, Maurizio, additional, Colombo, Alessandro, additional, Durante, Alessandro, additional, Fineschi, Massimo, additional, Nicolino, Annamaria, additional, Piraino, Davide, additional, Varricchio, Attilio, additional, Tespili, Maurizio, additional, Corrado, Donatella, additional, and Steffenino, Giuseppe, additional

Published
2016
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20. Post‐procedural hemodiafiltration in acute coronary syndrome patients with associated renal and cardiac dysfunction undergoing urgent and emergency coronary angiography

Author

Marenzi, Giancarlo, primary, Mazzotta, Gianfranco, additional, Londrino, Francesco, additional, Gistri, Roberto, additional, Moltrasio, Marco, additional, Cabiati, Angelo, additional, Assanelli, Emilio, additional, Veglia, Fabrizio, additional, and Rombolà, Giuseppe, additional

Published
2014
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31. Coronary vasodilation is impaired in both hypertrophied and nonhypertrophied myocardium of patients with hypertrophic cardiomyopathy: A study with nitrogen-13 ammonia and positron emission tomography

Author

Camici, Paolo, primary, Chiriatti, Giampaolo, additional, Lorenzoni, Roberto, additional, Bellina, Riccardo C., additional, Gistri, Roberto, additional, Italiani, Gessica, additional, Parodi, Oberdan, additional, Salvadori, Piero A., additional, Nista, Nicola, additional, Papi, Lauro, additional, and L'abbate, Antonio, additional

Published
1991
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38. Clinical findings after bioresorbable vascular scaffold implantation in an unrestricted cohort of patients with ST-segment elevation myocardial infarction (from the RAI registry)

Author

Gabriele Gabrielli, Massimo Fineschi, Donatella Corrado, Leonardo Misuraca, Maurizio Ferrario, Bruno Loi, Elisabetta Moscarella, Sebastian Coscarelli, Maria Carmen De Angelis, Gabriele Tumminello, Francesco Pisano, Paolo Calabrò, Bernardo Cortese, Alfonso Ielasi, Michela Facchin, Attilio Varricchio, Roberto Gistri, Maurizio Tespili, Pietro Mazzarotto, Alessandro Colombo, Giuseppe Tarantini, Davide Piraino, Alessandro Durante, Valerio Lucci, Giuseppe Steffenino, Luciano Moretti, Annamaria Nicolino, Moscarella, Elisabetta, Ielasi, Alfonso, Varricchio, Attilio, De Angelis, Maria Carmen, Loi, Bruno, Tarantini, Giuseppe, Calabro', Paolo, Cortese, Bernardo, Mazzarotto, Pietro, Gabrielli, Gabriele, Pisano, Francesco, Facchin, Michela, Misuraca, Leonardo, Lucci, Valerio, Gistri, Roberto, Tumminello, Gabriele, Moretti, Luciano, Colombo, Alessandro, Durante, Alessandro, Fineschi, Massimo, Piraino, Davide, Ferrario, Maurizio, Coscarelli, Sebastian, Nicolino, Annamaria, Tespili, Maurizio, Corrado, Donatella, and Steffenino, Giuseppe

Subjects
Male, medicine.medical_specialty, medicine.medical_treatment, Percutaneous coronary interventions, Population, 030204 cardiovascular system & hematology, Cohort Studies, STEMI, 03 medical and health sciences, 0302 clinical medicine, Percutaneous Coronary Intervention, Internal medicine, Bioresorbable vascular scaffolds, Cardiology and Cardiovascular Medicine, Absorbable Implants, medicine, ST segment, Humans, cardiovascular diseases, 030212 general & internal medicine, Myocardial infarction, Prospective Studies, Registries, education, Aged, education.field_of_study, Tissue Scaffolds, business.industry, Percutaneous coronary intervention, Thrombolysis, Middle Aged, medicine.disease, Thrombosis, Blood Vessel Prosthesis, Bioresorbable vascular scaffold, surgical procedures, operative, Italy, Conventional PCI, Cohort, Cardiology, ST Elevation Myocardial Infarction, Female, Vascular Grafting, business
Abstract

Background The bioresorbable vascular scaffold (BVS) technology may be an appealing option in ST-segment elevation myocardial infarction (STEMI) patients. However, the available evidence on its use in this challenging subset is limited. Methods Registro Absorb Italiano (RAI) is a multicenter, prospective registry that aims to assess BVS performance through a 5-year follow-up of all consecutive patients who undergone at least 1 successful BVS implantation. As a part of it, a subgroup analysis in STEMI patients was performed and the outcomes of this cohort compared to the remaining population (defined as "non-STEMI") are reported here. Results Among the 1505 patients enrolled, 317 (21.1%) had STEMI on admission. Among those, 232 (73.2%) underwent primary percutaneous coronary intervention (PCI) within 12 h from symptom onset; 64 (20.2%) were late-comers (>12 h); 16 (5%) underwent PCI after successful thrombolysis while 5 (1.6%) underwent rescue-PCI. At a median follow-up time of 12 months (IQR 6–20 months) no differences were noticed between STEMI and "non-STEMI" groups in terms of device-oriented composite endpoint (4.1% vs. 5.6%; p = 0.3) and its singular components: ischemia-driven target lesion revascularization (3.2% vs. 3.6%; p = 0.7), target-vessel myocardial infarction (3.2% vs. 2.8%; p = 0.7) and cardiac death (0.6% vs. 0.6%; p = 0.9). The rate of definite/probable scaffold thrombosis (ScT) was numerically higher but not significant in the STEMI group (2.5% vs. 1.3%; p = 0.1). Conclusions BVS implantation in an unrestricted cohort of STEMI patients is associated with a numerically higher rate of ScT compared to the non-STEMI group. Further studies exploring the potential clinical impact of a pre-specified BVS implantation strategy in this high-risk clinical setting are needed.

Published
2018

39. 'Full-plastic jacket' with everolimus-eluting Absorb bioresorbable vascular scaffolds: Clinical outcomes in the multicenter prospective RAI registry (ClinicalTrials.gov Identifier: NCT02298413)

Author

Gabriele Gabrielli, Paolo Calabrò, Leonardo Misuraca, all Rai investigators, Donatella Corrado, Giuseppe Tarantini, Francesco Pisano, Alessandro Colombo, Bernardo Cortese, Annamaria Nicolino, Gabriele Tumminello, Giuseppe Steffenino, Giulia Masiero, Pietro Mazzarotto, Bruno Loi, Attilio Varricchio, Paola Tellaroli, Roberto Gistri, Marco Mojoli, Alessandro Durante, Luciano Moretti, Luca Nai Fovino, Zoran Olivari, Tarantini, Giuseppe, Masiero, Giulia, Fovino, Luca Nai, Mojoli, Marco, Varricchio, Attilio, Loi, Bruno, Gistri, Roberto, Misuraca, Leonardo, Gabrielli, Gabriele, Cortese, Bernardo, Pisano, Francesco, Moretti, Luciano, Tumminello, Gabriele, Olivari, Zoran, Mazzarotto, Pietro, Colombo, Alessandro, Calabrò, Paolo, Nicolino, Annamaria, Tellaroli, Paola, Corrado, Donatella, Durante, Alessandro, and Steffenino, Giuseppe

Subjects
Male, medicine.medical_specialty, Target vessel, Coronary Artery Disease, 030204 cardiovascular system & hematology, Repeat revascularization, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Absorbable Implants, Medicine, Humans, 030212 general & internal medicine, Stent thrombosis, Everolimus, Prospective Studies, Registries, Full-plastic jacket, Bioresorbable vascular scaffold, Absorb BVS, BRS, Diffuse coronary disease, Cardiology and Cardiovascular Medicine, Aged, Tissue Scaffolds, business.industry, Drug-Eluting Stents, Middle Aged, medicine.disease, Blood Vessel Prosthesis, Treatment Outcome, Conventional PCI, Cardiology, Female, business, medicine.drug, Follow-Up Studies
Abstract

Objectives The objective of this study was to investigate mid-term clinical outcomes of patients treated with ‘full-plastic jacket’ (FPJ) everolimus-eluting Absorb bioresorbable vascular scaffold (BRS) implantation. Background FPJ with BRS may represent an interesting option for patient with diffuse coronary artery disease (CAD), but data on the clinical impact of FPJ using the Absorb BRS are scant. Methods FPJ was defined as the implantation of >56 mm of overlapping BRS in at least one vessel. We compared outcomes of patients receiving Absorb FPJ vs. non-FPJ within the multicenter prospective RAI Registry. Results Out of 1505 consecutive patients enrolled in the RAI registry, 1384 were eligible for this analysis. Of these, 143 (10.3%) were treated with BRS FPJ. At a median follow-up of 649 days, no differences were observed between FPJ and non-FPJ groups in terms of the device-oriented composite endpoint (DoCE) (5.6% vs. 4.4%, p = 0.675) or the patient-related composite endpoint (PoCE) (20.9% vs. 15.9%, p = 0.149). Patients receiving FPJ had higher rates of target vessel repeat revascularization (TVR) (11.2% vs. 6.3%, p = 0.042). In the FPJ group, there was no cardiac death and only one (very late) stent thrombosis (ST) (0.7%). Conclusions Mid-term outcomes of a FPJ PCI strategy in the setting of diffuse CAD did not show a significant increase in composite device- and patient-related events, with rates of cardiac death and ST comparable to non-FPJ Absorb BRS implantation. However, these findings are hypothesis generating and requiring further validation.

Published
2018

40. Clinical outcomes of overlapping versus non-overlapping everolimus-eluting absorb bioresorbable vascular scaffolds: An analysis from the multicentre prospective RAI registry (ClinicalTrials.gov identifier: NCT02298413)

Author

Giuseppe, Tarantini, Marco, Mojoli, Giulia, Masiero, Bernardo, Cortese, Bruno, Loi, Attilio, Varricchio, Gabriele, Gabrielli, Alessandro, Durante, Giampaolo, Pasquetto, Paolo, Calabrò, Roberto, Gistri, Gabriele, Tumminello, Leonardo, Misuraca, Francesco, Pisano, Alfonso, Ielasi, Pietro, Mazzarotto, Sebastian, Coscarelli, Valerio, Lucci, Luciano, Moretti, Annamaria, Nicolino, Alessandro, Colombo, Zoran, Olivari, Massimo, Fineschi, Davide, Piraino, Luigi, Piatti, Umberto, Canosi, Paola, Tellaroli, Donatella, Corrado, Chiara, Rovera, Giuseppe, Steffenino, Tarantini, Giuseppe, Mojoli, Marco, Masiero, Giulia, Cortese, Bernardo, Loi, Bruno, Varricchio, Attilio, Gabrielli, Gabriele, Durante, Alessandro, Pasquetto, Giampaolo, Calabro', Paolo, Gistri, Roberto, Tumminello, Gabriele, Misuraca, Leonardo, Pisano, Francesco, Ielasi, Alfonso, Mazzarotto, Pietro, Coscarelli, Sebastian, Lucci, Valerio, Moretti, Luciano, Nicolino, Annamaria, Colombo, Alessandro, Olivari, Zoran, Fineschi, Massimo, Piraino, Davide, Piatti, Luigi, Canosi, Umberto, Tellaroli, Paola, Corrado, Donatella, Rovera, Chiara, and Steffenino, Giuseppe

Subjects
Male, Bioresorbable stents, Time Factors, Myocardial Ischemia, long lesion, Coronary Angiography, Prosthesis Design, Percutaneous Coronary Intervention, Coated Materials, Biocompatible, Recurrence, Risk Factors, Nuclear Medicine and Imaging, Absorbable Implants, Humans, overlap, Everolimus, Prospective Studies, Registries, Ultrasonography, Interventional, Aged, complex lesion, Cardiovascular Agents, Complex lesions, Long lesions, Overlap, Radiology, Nuclear Medicine and Imaging, Cardiology and Cardiovascular Medicine, Middle Aged, Treatment Outcome, Italy, bioresorbable stent, Female, Radiology, Tomography, Optical Coherence
Abstract

ObjectivesTo compare clinical outcomes of patients treated with overlapping versus non-overlapping Absorb BVS. Background: Limited data are available on the clinical impact of stent overlap with the Absorb BVS bioresorbable stent. Methods: We compared outcomes of patients receiving overlapping or non-overlapping Absorb BVS in the multicenter prospective RAI Registry. Results: Out of 1,505 consecutive patients treated with Absorb BVS, 1,384 were eligible for this analysis. Of these, 377 (27%) were in the overlap group, and 1,007 (73%) in the non-overlap group. The most frequent overlap configuration was the marker-to-marker type (48%), followed by marker-over-marker (46%) and marker-inside-marker (6%) types. Patients of the overlap group had higher prevalence of multivessel disease and higher SYNTAX score, and required more frequently the use of intravascular imaging. At a median follow-up of 368 days, no difference was observed between overlap and non-overlap groups in terms of a device-related composite endpoint (cardiac death, TV-MI, ID-TLR) (5.8% vs. 4.1%, P=0.20) or of a patient-related composite endpoint (any death, any MI, any revascularization) (15.4% vs. 12.5%, P=0.18). Cardiac death (1.0% vs. 1.3%, P=0.54), MI (4.5% vs. 3.6%, P=0.51), TVR (4.5% vs. 3.6%, P=0.51) and stent thrombosis (1.1 vs. 1.5%, P=1.00) were also comparable between groups. When assessing outcomes of the overlap population according to overlap configurations used, no difference was observed in terms of the device- or patient-related composite endpoints. Conclusions: Outcomes of patients with or without overlapping BVS were comparable at mid-term follow-up despite higher angiographic complexity of the overlap subset. (c) 2017 Wiley Periodicals, Inc.

Published
2018

41. [Right ventricular involvement in hypertrophic cardiomyopathy. A case report and brief review of the literature].

Author

Comella A, Magnacca M, Gistri R, Lombardi M, Neglia D, Poddighe R, and Pesola A

Subjects
Adrenergic beta-Antagonists therapeutic use, Adult, Angina Pectoris etiology, Atenolol therapeutic use, Cardiomyopathy, Hypertrophic complications, Cardiomyopathy, Hypertrophic diagnostic imaging, Cardiomyopathy, Hypertrophic drug therapy, Cardiomyopathy, Hypertrophic epidemiology, Echocardiography, Electrocardiography, Ambulatory, Exercise Test, Heart Septum diagnostic imaging, Heart Septum pathology, Hemodynamics, Humans, Hypertrophy, Right Ventricular complications, Hypertrophy, Right Ventricular diagnostic imaging, Hypertrophy, Right Ventricular drug therapy, Male, Physical Exertion, Prevalence, Tricuspid Valve diagnostic imaging, Tricuspid Valve pathology, Cardiomyopathy, Hypertrophic pathology, Hypertrophy, Right Ventricular pathology
Abstract

A clinical case of non-obstructive hypertrophic cardiomyopathy with involvement of the right ventricle is reported. The patient was a 42-year-old male with symptoms suggesting an effort angina of recent onset. The diagnosis was established by echocardiography, which showed asymmetric hypertrophy of the interventricular septum (20 mm), hypertrophy of the right ventricular free wall, and severe hypertrophy of the septal papillary muscle of the tricuspid valve. The patient underwent a complete diagnostic evaluation, including exercise stress test, Holter monitoring, magnetic resonance, myocardial tomoscintigraphy and complete hemodynamic assessment. Medical treatment with atenolol 50 mg day was started; at 1-year follow-up the patient's clinical conditions are good, with decrease of anginal episodes. The literature review elicits the paucity of information about this condition, despite a frequent involvement of both ventricles in hypertrophic obstructive cardiomyopathy. The case reported shows two atypical aspects: a) the involvement of the right ventricle in non-obstructive hypertrophic cardiomyopathy is anecdotal; b) this pattern of hypertrophy (right ventricular free wall/septal papillary muscle) has never been previously reported. Right ventricular involvement in patients with hypertrophic cardiomyopathy must be carefully investigated, because it may be more frequent than conventionally deemed.

Published
2004

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