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7. Factor Xa Inhibition Reduces Coagulation Activity but Not Inflammation Among People With HIV: A Randomized Clinical Trial

Author

Baker, Jason V, primary, Wolfson, Julian, additional, Peterson, Tess, additional, Mooberry, Micah, additional, Gissel, Matthew, additional, Mystakelis, Harry, additional, Henderson, Michael W, additional, Garcia-Myers, Kelly, additional, Rhame, Frank S, additional, Schacker, Timothy W, additional, Brummel-Ziedins, Kathleen E, additional, Sereti, Irini, additional, Key, Nigel S, additional, and Tracy, Russell P, additional

Published
2020
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9. Factor X Inhibition Reduces Coagulation Activity But Not Inflammation Among Persons Living with HIV: A Randomized Clinical Trial

Author

Baker, Jason, primary, Wolfson, Julian, additional, Peterson, Tess, additional, Mooberry, Micah, additional, Gissel, Matthew, additional, Mystakelis, Harry, additional, Henderson, Michael W., additional, Garcia-Myers, Kelly, additional, Rhame, Frank S., additional, Schacker, Timothy W., additional, Brummel-Ziedins, Kathleen E., additional, Sereti, Irini, additional, Key, Nigel S., additional, Tracy, Russell P., additional, and Study, TACTICAL-HIV, additional

Published
2019
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15. The influence of prophylactic factor VIII in severe hemophilia A

Author

Gissel, Matthew, Whelihan, Matthew F, Ferris, Lauren A, Mann, Kenneth G, Rivard, Georges E, and Brummel-Ziedins, Kathleen E

Subjects
Adult, Cohort Studies, Young Adult, Factor VIII, Adolescent, Blotting, Western, Thrombin, Humans, Regression Analysis, Computer Simulation, Hemophilia A, Blood Coagulation, Article
Abstract

Haemophilia A individuals displaying a similar genetic defect have heterogeneous clinical phenotypes. Our objective was to evaluate the underlying effect of exogenous factor (f)VIII on tissue factor (Tf)-initiated blood coagulation in severe haemophilia utilizing both empirical and computational models. We investigated twenty-five clinically severe haemophilia A patients. All individuals were on fVIII prophylaxis and had not received fVIII from 0.25 to 4 days prior to phlebotomy. Coagulation was initiated by the addition of Tf to contact-pathway inhibited whole blood ± an anti-fVIII antibody. Aliquots were quenched over 20 min and analyzed for thrombin generation and fibrin formation. Coagulation factor levels were obtained and used to computationally predict thrombin generation with fVIII set to either zero or its value at the time of the draw. As a result of prophylactic fVIII, at the time of the blood draw, the individuals had fVIII levels that ranged from1% to 22%. Thrombin generation (maximum level and rate) in both empirical and computational systems increased as the level of fVIII increased. FXIII activation rates also increased as the fVIII level increased. Upon suppression of fVIII, thrombin generation became comparable in both systems. Plasma composition analysis showed a negative correlation between bleeding history and computational thrombin generation in the absence of fVIII. Residual prophylactic fVIII directly causes an increase in thrombin generation and fibrin cross-linking in individuals with clinically severe haemophilia A. The combination of each individual's coagulation factors (outside of fVIII) determine each individual's baseline thrombin potential and may affect bleeding risk.

Published
2011

16. Active tissue factor and activated factor XI in patients with acute ischemic cerebrovascular events

Author

Undas, Anetta, Slowik, Agnieszka, Gissel, Matthew, Mann, Kenneth G., and Butenas, Saulius

Subjects
Male, Time Factors, Middle Aged, Prognosis, Severity of Illness Index, Article, Factor XIa, Thromboplastin, Ischemic Attack, Transient, Predictive Value of Tests, Humans, Female, Blood Coagulation Tests, Blood Coagulation, Aged
Abstract

Elevated factor (F)XI and tissue factor (TF) have been reported to occur in patients with acute ischemic stroke (AIS). We sought to investigate whether circulating activated FXI (FXIa) and TF on admission can predict clinical outcomes in patients with acute cerebrovascular events. In the observational study, we evaluated 205 consecutive patients aged 70 years or less within the first 72 h of acute event, including 140 with AIS and 65 with transient ischemic attack (TIA). Plasma TF and FXIa activity were determined on admission in clotting assays by measuring the response to inhibitory monoclonal antibodies.Active TF and FXIa activity were detected in 58 (28·9%) and 132 (64·4%) patients on admission, respectively. Active TF was detected in 45 of the 136 AIS patients with available TF levels (33·1%) and 13 of the 65 patients with acute TIA (20%; 0·05). Corresponding values for FXIa were 99 of the 140 (70·7%) and 33 of the 65 (50·8%; P= 0·006), respectively. Patients with detectable TF were more frequently women and hypertensive, while subjects with detectable FXIa had more often diabetes and higher levels of fibrinogen, C-reactive protein and interleukin-6 (all P0·05). Patients with detectable FXIa but not TF had higher National Institutes of Health Stroke Scale score, higher modified Rankin scale score and lower Barthel Index at discharge (all P0·05).Circulating active TF and FXIa occur frequently in acute cerebrovascular ischemic events. Active FXIa in plasma might be useful as a novel risk marker of worse functional outcomes in patients with acute cerebrovascular events.

Published
2011

36. Demystifying Tissue Factor.

Author

Butenas, Saulius, primary, Gissel, Matthew T., additional, Bouchard, Beth A., additional, Brummel, Kathleen E., additional, Parhami-Seren, Behnaz, additional, and Mann, Kenneth G., additional

Published
2004
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