6 results on '"Giseg"'
Search Results
2. Gender oncology: recommendations and consensus of the Italian Association of Medical Oncology (AIOM).
- Author
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Berardi R, Rossi F, Papa R, Appetecchia M, Baggio G, Bianchini M, Mazzei T, Maria Moretti A, Ortona E, Pietrantonio F, Tarantino V, Vavalà T, and Cinieri S
- Subjects
- Humans, Italy epidemiology, Medical Oncology, Neoplasms epidemiology, Neoplasms therapy
- Abstract
Background: Following the development of gender medicine in the past 20 years, more recently in the field of oncology an increasing amount of evidence suggests gender differences in the epidemiology of cancers, as well as in the response and toxicity associated with therapies. In a gender approach, critical issues related to sexual and gender minority (SGM) populations must also be considered., Materials and Methods: A working group of opinion leaders approved by the Italian Association of Medical Oncology (AIOM) has been set up with the aim of drafting a shared document on gender oncology. Through the 'consensus conference' method of the RAND/University of California Los Angeles (UCLA) variant, the members of the group evaluated statements partly from the scientific literature and partly produced by the experts themselves [good practice points (GPPs)], on the following topics: (i) Healthcare organisation, (ii) Therapy, (iii) Host factors, (iv) Cancer biology, and (v) Communication and social interventions. Finally, in support of each specific topic, they considered it appropriate to present some successful case studies., Results: A total of 42 articles met the inclusion criteria, from which 50 recommendations were extracted. Panel participants were given the opportunity to propose additional evidence from studies not included in the research results, from which 32 statements were extracted, and to make recommendations not derived from literature such as GPPs, four of which have been developed. After an evaluation of relevance by the panel, it was found that 81 recommendations scored >7, while 3 scored between 4 and 6.9, and 2 scored below 4., Conclusions: This consensus and the document compiled thereafter represent an attempt to evaluate the available scientific evidence on the theme of gender oncology and to suggest standard criteria both for scientific research and for the care of patients in clinical practice that should take gender into account., Competing Interests: Disclosure RB grants or contracts from any entity: Roche, Pfizer, AZ, to institution; payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events: Gilead, Seagen, GSK, Eisai, BMS, Lilly, MSD, Boeringher. TV reports payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events: Helaglobe/Recordati, Astrazeneca; support for attending meetings and/or travel: Sanofi-Regeneron; participation on a Data Safety Monitoring Board or Advisory Board: Takeda; leadership or fiduciary role in other board, society, committee or advocacy group, paid or unpaid: Regional Referent for GISEG (Italian Group Health and Gender). FP reports institutional research grants from: BMS, Incyte, Agenus, Amgen, Lilly and AstraZeneca; personal fees from: BMS, MSD, Amgen, Merck-Serono, Pierre-Fabre, Servier, Bayer, Takeda, Astellas, Johnson & Johnson, Rottapharm, Ipsen, AstraZeneca, GSK, Daiichi-Sankyo, Seagen. SC is the President of AIOM Foundation (Italian Association of Medical Oncology). The remaining authors have no conflicts of interest to declare., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2024
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3. Sex and Gender-Related Differences in the Outcome of Total Hip Arthroplasty: A Current Concepts Review.
- Author
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Solarino G, Bizzoca D, Moretti AM, D'Apolito R, Moretti B, and Zagra L
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- Male, Humans, Female, Postoperative Complications prevention & control, Postoperative Complications etiology, Patient Satisfaction, Sexual Behavior, Treatment Outcome, Arthroplasty, Replacement, Hip adverse effects
- Abstract
Background and Objectives: Sex and gender-related differences may influence the outcome of patients undergoing total hip arthroplasty (THA). The present paper aims to depict the importance of sex and gender-related issues in the perioperative management of patients undergoing THA to improve clinical outcomes and prevent postoperative complications. Materials and Methods: From January 2002 to August 2022, OVID-MEDLINE, EMBASE, SCOPU S, Web of Science, Google Scholar, and PubMed were searched to identify relevant studies for further analysis. The search strategy included the following terms: (("gender-related differences" [MeSH Terms] OR "sex-related differences" [All Fields]) OR ("gender indicators" [MeSH Terms] OR "sex" [All Fields])) AND ("total hip arthroplasty" [MeSH Terms] OR (total hip replacement [All Fields])). Results: Twenty-eight papers were included in this current concepts review. Sex and gender-related differences were analyzed with regard to the following points: (1) surgical approach, robotic surgery, scar cosmesis, and implant choice; (2) postoperative clinical outcome and complications; (3) sexual activity after THA; and (4) psychological status and daily functional requirements. The data analysis showed that female patients need more specific attention in the preoperative, intraoperative, and postoperative phases to improve clinical and functional outcomes, reduce complications risk, and manage patient satisfaction. Conclusions: THA outcomes may be influenced by sex and gender-related factors which should be carefully assessed and addressed in patients undergoing surgery to improve the postoperative outcomes of patients' satisfaction and reduce postoperative complications that can differ between the two sexes.
- Published
- 2022
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4. Gender differences in vaccine therapy: where are we in COVID-19 pandemic?
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Ciarambino T, Barbagelata E, Corbi G, Ambrosino I, Politi C, Lavalle F, Ruggieri A, and Moretti A
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- Adolescent, Adult, Aged, Child, Female, Humans, Immunotherapy, Active, Male, Middle Aged, Pandemics prevention & control, Pregnancy, Prospective Studies, Retrospective Studies, SARS-CoV-2, Sex Factors, Young Adult, COVID-19, Vaccines
- Abstract
Vaccination is one of the greatest achievements of public health. Vaccination programs have contributed to the decline in mortality and morbidity of various infectious diseases. This review aims to investigate the impact of sex/gender on the vaccine acceptance, responses, and outcomes. The studies were identified by using PubMed, until 30th June 2020. The search was performed by using the following keywords: SARS-CoV-2, COVID-19, gender, sex, vaccine, adverse reaction. Clinical trials, retrospective and prospective studies were included. Studies written in languages other than English were excluded. Studies were included if gender differences in response to vaccination trials were reported. All selected studies were qualitatively analyzed. Innate recognition and response to viruses, as well as, adaptive immune responses during viral infections, differ between females and males. Unfortunately, a majority of vaccine trials have focused on healthy people, with ages between 18 to 65 years, excluding the elderly, pregnant women, post-menopausal female and children. In conclusion, it is apparent that the design of vaccines and vaccine strategies should be sex-specific, to reduce adverse reactions in females and increase immunogenicity in males. It should be mandatory to examine sex-related variables in pre-clinical and clinical vaccine trials, such as their crucial role for successful prevention of pandemic COVID-19.
- Published
- 2021
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5. Gender differences in treatment of Coronavirus Disease-2019.
- Author
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Ambrosino I, Barbagelata E, Corbi G, Ciarambino T, Politi C, and Moretti AM
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- Adenosine Monophosphate analogs & derivatives, Adenosine Monophosphate therapeutic use, Adult, Aged, Alanine analogs & derivatives, Alanine therapeutic use, Amides therapeutic use, Antimalarials therapeutic use, Antiviral Agents therapeutic use, COVID-19 mortality, COVID-19 therapy, COVID-19 virology, Cardiovascular Diseases complications, Cardiovascular Diseases epidemiology, Chloroquine therapeutic use, Clinical Trials as Topic, Combined Modality Therapy, Diabetes Complications epidemiology, Female, Humans, Hypertension complications, Hypertension epidemiology, Immunity genetics, Immunization, Passive methods, Immunoglobulins therapeutic use, Lopinavir therapeutic use, Male, Middle Aged, Mortality trends, Pandemics prevention & control, Pandemics statistics & numerical data, Pyrazines therapeutic use, Ritonavir therapeutic use, COVID-19 Serotherapy, COVID-19 epidemiology, SARS-CoV-2 genetics, Sex Characteristics, COVID-19 Drug Treatment
- Abstract
Coronavirus Disease-2019 (COVID-19) is the worst worldwide pandemic with more than 12,000,000 cases and 560,000 deaths until 14th July 2020. Men were more infected by COVID-19 than women, and male subjects with underlying conditions, including diabetes, hypertension, and cardiovascular diseases developed a severe form of the affection, with increased mortality rate. Many factors can contribute to the disparity in disease outcomes, such as hormone-specific reaction and activity of X-linked genes, which modulate the innate and adaptive immune response to virus infection. Until now, only the Remdesivir was approved by FDA (Food Drug Administration) for COVID-19 treatment, although several clinical trials are ongoing worldwide also on other drugs. In this review, we analyzed published studies on several drugs (chloroquine or hydroxychloroquine, remdesivir, favipiravir, lopinavir-ritonavir in combination, tocilizumab, plasma, and immunoglobulins) with some efficacy to COVID-19 in humans, and evaluated if there were a gender analysis of the available data. In our opinion, it is essential to report data about COVID-19 disaggregated by sex, age, and race, because the knowledge of gender differences is fundamental to identify effective and customized treatments to reduce hospitalizations, admissions to intensive care units, and mortality.
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- 2020
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6. Gender differences in patients with COVID-19: a narrative review.
- Author
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Ambrosino I, Barbagelata E, Ortona E, Ruggieri A, Massiah G, Giannico OV, Politi C, and Moretti AM
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- Angiotensin-Converting Enzyme 2, Animals, Betacoronavirus genetics, COVID-19, Comorbidity, Coronavirus Infections diagnosis, Coronavirus Infections mortality, Humans, Immunity, Innate, Pandemics, Peptidyl-Dipeptidase A metabolism, Pneumonia, Viral diagnosis, Pneumonia, Viral mortality, Prevalence, Prognosis, Risk Factors, SARS-CoV-2, Serine Endopeptidases metabolism, Sex Factors, Virus Attachment, Betacoronavirus physiology, Coronavirus Infections epidemiology, Coronavirus Infections physiopathology, Pneumonia, Viral epidemiology, Pneumonia, Viral physiopathology
- Abstract
In December 2019 a novel coronavirus emerged in Wuhan, China causing many cases of severe pneumonia. World Health Organization (WHO) named this disease Coronavirus Disease 2019 (COVID-19). The infection has rapidly spread across China to many other countries, and on March 12, 2020 the WHO declared pandemic outbreak of COVID-19. As of May 16, 2020, COVID-19 has been diagnosed in more than 4,490,000 patients, associated to 305,976 deaths worldwide; in Italy 224,760 COVID-19 cases have been reported with 31,763 deaths. The main routes of transmission are respiratory droplets and direct contact with infected people, so numerous prevention strategies are employed to mitigate the spread of disease, including social distancing and isolation. The aim of this narrative review is to underline gender differences in epidemiology, etiopathogenesis, risk factors, clinical presentation, diagnosis, prognosis and mortality of patients infected with SARS-CoV-2. Currently data on the sex indicators for admitted or deceased patients are only available, but there is no analysis about other gender indicators. The data considered in our study are the only currently available in the literature, but it is appropriate to implement a specific analysis with all gender indicators to identify appropriate strategies. Moreover, the evaluation of a health service efficiency is a key element to define gender outcomes. Knowing the gender differences in COVID-19 outbreak would be a fundamental tool to understand the effects of a health emergency on individuals and communities as well as to carry out effective and equitable policies, public health measures and targeted solutions.
- Published
- 2020
- Full Text
- View/download PDF
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