Search

Your search keyword '"Giry, Marine"' showing total 41 results
Start Over Author "Giry, Marine"
41 results on '"Giry, Marine"'

1. Initial surgical resection and long time to occurrence from initial diagnosis are independent prognostic factors in resected recurrent IDH wild-type glioblastoma

Author

Seyve, Antoine, Lozano-Sanchez, Fernando, Thomas, Alice, Mathon, Bertrand, Tran, Suzanne, Mokhtari, Karima, Giry, Marine, Marie, Yannick, Capelle, Laurent, Peyre, Matthieu, Carpentier, Alexandre, Feuvret, Loic, Sanson, Marc, Hoang-Xuan, Khê, Honnorat, Jérome, Delattre, Jean-Yves, Ducray, François, and Idbaih, Ahmed

Published
2020
Full Text
View/download PDF

2. Mechanisms and therapeutic implications of hypermutation in gliomas

Author

Touat, Mehdi, Li, Yvonne Y., Boynton, Adam N., Spurr, Liam F., Iorgulescu, J. Bryan, Bohrson, Craig L., Cortes-Ciriano, Isidro, Birzu, Cristina, Geduldig, Jack E., Pelton, Kristine, Lim-Fat, Mary Jane, Pal, Sangita, Ferrer-Luna, Ruben, Ramkissoon, Shakti H., Dubois, Frank, Bellamy, Charlotte, Currimjee, Naomi, Bonardi, Juliana, Qian, Kenin, Ho, Patricia, Malinowski, Seth, Taquet, Leon, Jones, Robert E., Shetty, Aniket, Chow, Kin-Hoe, Sharaf, Radwa, Pavlick, Dean, Albacker, Lee A., Younan, Nadia, Baldini, Capucine, Verreault, Maïté, Giry, Marine, Guillerm, Erell, Ammari, Samy, Beuvon, Frédéric, Mokhtari, Karima, Alentorn, Agusti, Dehais, Caroline, Houillier, Caroline, Laigle-Donadey, Florence, Psimaras, Dimitri, Lee, Eudocia Q., Nayak, Lakshmi, McFaline-Figueroa, J. Ricardo, Carpentier, Alexandre, Cornu, Philippe, Capelle, Laurent, Mathon, Bertrand, Barnholtz-Sloan, Jill S., Chakravarti, Arnab, Bi, Wenya Linda, Chiocca, E. Antonio, Fehnel, Katie Pricola, Alexandrescu, Sanda, Chi, Susan N., Haas-Kogan, Daphne, Batchelor, Tracy T., Frampton, Garrett M., Alexander, Brian M., Huang, Raymond Y., Ligon, Azra H., Coulet, Florence, Delattre, Jean-Yves, Hoang-Xuan, Khê, Meredith, David M., Santagata, Sandro, Duval, Alex, Sanson, Marc, Cherniack, Andrew D., Wen, Patrick Y., Reardon, David A., Marabelle, Aurélien, Park, Peter J., Idbaih, Ahmed, Beroukhim, Rameen, Bandopadhayay, Pratiti, Bielle, Franck, and Ligon, Keith L.

Published
2020
Full Text
View/download PDF

4. A threshold for mitotic activity and post‐surgical residual volume defines distinct prognostic groups for astrocytoma IDH‐mutant

Author

Tran, Suzanne, primary, Thomas, Alice, additional, Aliouat, Ilyes, additional, Karachi, Carine, additional, Lozano, Fernando, additional, Mokhtari, Karima, additional, Dehais, Caroline, additional, Feuvret, Loïc, additional, Carpentier, Catherine, additional, Giry, Marine, additional, Doukani, Abiba, additional, Lerond, Julie, additional, Marie, Yannick, additional, Sanson, Marc, additional, Idbaih, Ahmed, additional, Carpentier, Alexandre, additional, Hoang‐Xuan, Khê, additional, Touat, Mehdi, additional, Capelle, Laurent, additional, and Bielle, Franck, additional

Published
2023
Full Text
View/download PDF

5. Hypersomnia in anti‐glutamic acid decarboxylase 65 (GAD65) associated neurological syndromes: A pilot study.

Author

Jeantin, Lina, Gales, Ana, Berzero, Giulia, Leu, Smaranda, Proust, Jérémy, Giry, Marine, Valyraki, Nefeli Eirini, Birzu, Cristina, Alentorn, Agusti, Vidailhet, Marie, Psimaras, Dimitri, and Arnulf, Isabelle

Subjects
HYPERSOMNIA, SLEEP duration, SLEEP latency, STIFF-person syndrome, SLEEP disorders, SYNDROMES
Abstract

Background and purpose: Despite their detrimental impact on the quality of life in autoimmune encephalitis, sleep disorders have not been investigated in anti‐glutamic acid decarboxylase (GAD65) associated neurological syndromes. Methods: Six consecutive adult patients diagnosed with anti‐GAD65‐associated neurological syndromes (four with limbic encephalitis and two with stiff‐person syndrome) and 12 healthy controls were enrolled. Participants underwent sleep interviews and sleep studies including night‐time video‐polysomnography, followed by five daytime multiple sleep latency tests (MSLTs, to assess propensity to fall asleep) and an 18 h bed rest polysomnography (to assess excessive sleep need). Results: Patients reported the need for daily naps and that their cognition and quality of life were altered by sleepiness, but they had normal scores on the Epworth sleepiness scale. Compared with controls, sleep latencies during the MSLT were shorter in the patient group (median 5.8 min, interquartile range [IQR] 4.5, 6.0 vs. 17.7 min, IQR 16.3, 19.7, p = 0.001), and the arousal index was reduced (2.5/h, IQR 2.3, 3.0 vs. 22.3/h, IQR 13.8, 30.0, p = 0.002), although total sleep time was similar between groups (621 min, IQR 464, 651 vs. 542.5 min, IQR 499, 582, p = 0.51). Remarkably, all six patients had MSLT latencies ≤8 min, indicating severe sleepiness. No parasomnia or sleep‐disordered breathing was detected. Conclusion: Central hypersomnia is a relevant characteristic of anti‐GAD65‐associated neurological syndromes. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

7. Spatial and Ecological Factors Modulate the Incidence of Anti-NMDAR Encephalitis—A Systematic Review

Author

Alentorn, Agustí, primary, Berzero, Giulia, additional, Alexopoulos, Harry, additional, Tzartos, John, additional, Botero, Germán Reyes, additional, Martínez, Andrea Morales, additional, Muñiz-Castrillo, Sergio, additional, Vogrig, Alberto, additional, Joubert, Bastien, additional, Jiménez, Francisco A. García, additional, Cabrera, Dagoberto, additional, Tobon, José Vladimir, additional, Delgado, Carolina, additional, Sandoval, Patricio, additional, Troncoso, Mónica, additional, Galleguillos, Lorna, additional, Giry, Marine, additional, Benazra, Marion, additional, Verdin, Isaias Hernández, additional, Dade, Maëlle, additional, Picard, Géraldine, additional, Rogemond, Véronique, additional, Weiss, Nicolas, additional, Dalakas, Marinos C., additional, Boëlle, Pierre-Yves, additional, Delattre, Jean-Yves, additional, Honnorat, Jérôme, additional, and Psimaras, Dimitri, additional

Published
2023
Full Text
View/download PDF

8. Supplementary Figure 5 from Detection, Characterization, and Inhibition of FGFR–TACC Fusions in IDH Wild-type Glioma

Author

Di Stefano, Anna Luisa, primary, Fucci, Alessandra, primary, Frattini, Veronique, primary, Labussiere, Marianne, primary, Mokhtari, Karima, primary, Zoppoli, Pietro, primary, Marie, Yannick, primary, Bruno, Aurelie, primary, Boisselier, Blandine, primary, Giry, Marine, primary, Savatovsky, Julien, primary, Touat, Mehdi, primary, Belaid, Hayat, primary, Kamoun, Aurelie, primary, Idbaih, Ahmed, primary, Houillier, Caroline, primary, Luo, Feng R., primary, Soria, Jean-Charles, primary, Tabernero, Josep, primary, Eoli, Marica, primary, Paterra, Rosina, primary, Yip, Stephen, primary, Petrecca, Kevin, primary, Chan, Jennifer A., primary, Finocchiaro, Gaetano, primary, Lasorella, Anna, primary, Sanson, Marc, primary, and Iavarone, Antonio, primary

Published
2023
Full Text
View/download PDF

9. Supplementary Figure 2 from Detection, Characterization, and Inhibition of FGFR–TACC Fusions in IDH Wild-type Glioma

Author

Di Stefano, Anna Luisa, primary, Fucci, Alessandra, primary, Frattini, Veronique, primary, Labussiere, Marianne, primary, Mokhtari, Karima, primary, Zoppoli, Pietro, primary, Marie, Yannick, primary, Bruno, Aurelie, primary, Boisselier, Blandine, primary, Giry, Marine, primary, Savatovsky, Julien, primary, Touat, Mehdi, primary, Belaid, Hayat, primary, Kamoun, Aurelie, primary, Idbaih, Ahmed, primary, Houillier, Caroline, primary, Luo, Feng R., primary, Soria, Jean-Charles, primary, Tabernero, Josep, primary, Eoli, Marica, primary, Paterra, Rosina, primary, Yip, Stephen, primary, Petrecca, Kevin, primary, Chan, Jennifer A., primary, Finocchiaro, Gaetano, primary, Lasorella, Anna, primary, Sanson, Marc, primary, and Iavarone, Antonio, primary

Published
2023
Full Text
View/download PDF

10. Supplementary Figure 1 from Detection, Characterization, and Inhibition of FGFR–TACC Fusions in IDH Wild-type Glioma

Author

Di Stefano, Anna Luisa, primary, Fucci, Alessandra, primary, Frattini, Veronique, primary, Labussiere, Marianne, primary, Mokhtari, Karima, primary, Zoppoli, Pietro, primary, Marie, Yannick, primary, Bruno, Aurelie, primary, Boisselier, Blandine, primary, Giry, Marine, primary, Savatovsky, Julien, primary, Touat, Mehdi, primary, Belaid, Hayat, primary, Kamoun, Aurelie, primary, Idbaih, Ahmed, primary, Houillier, Caroline, primary, Luo, Feng R., primary, Soria, Jean-Charles, primary, Tabernero, Josep, primary, Eoli, Marica, primary, Paterra, Rosina, primary, Yip, Stephen, primary, Petrecca, Kevin, primary, Chan, Jennifer A., primary, Finocchiaro, Gaetano, primary, Lasorella, Anna, primary, Sanson, Marc, primary, and Iavarone, Antonio, primary

Published
2023
Full Text
View/download PDF

11. Supplementary Figure 6 from Detection, Characterization, and Inhibition of FGFR–TACC Fusions in IDH Wild-type Glioma

Author

Di Stefano, Anna Luisa, primary, Fucci, Alessandra, primary, Frattini, Veronique, primary, Labussiere, Marianne, primary, Mokhtari, Karima, primary, Zoppoli, Pietro, primary, Marie, Yannick, primary, Bruno, Aurelie, primary, Boisselier, Blandine, primary, Giry, Marine, primary, Savatovsky, Julien, primary, Touat, Mehdi, primary, Belaid, Hayat, primary, Kamoun, Aurelie, primary, Idbaih, Ahmed, primary, Houillier, Caroline, primary, Luo, Feng R., primary, Soria, Jean-Charles, primary, Tabernero, Josep, primary, Eoli, Marica, primary, Paterra, Rosina, primary, Yip, Stephen, primary, Petrecca, Kevin, primary, Chan, Jennifer A., primary, Finocchiaro, Gaetano, primary, Lasorella, Anna, primary, Sanson, Marc, primary, and Iavarone, Antonio, primary

Published
2023
Full Text
View/download PDF

12. Supplementary Figure Legends from Detection, Characterization, and Inhibition of FGFR–TACC Fusions in IDH Wild-type Glioma

Author

Di Stefano, Anna Luisa, primary, Fucci, Alessandra, primary, Frattini, Veronique, primary, Labussiere, Marianne, primary, Mokhtari, Karima, primary, Zoppoli, Pietro, primary, Marie, Yannick, primary, Bruno, Aurelie, primary, Boisselier, Blandine, primary, Giry, Marine, primary, Savatovsky, Julien, primary, Touat, Mehdi, primary, Belaid, Hayat, primary, Kamoun, Aurelie, primary, Idbaih, Ahmed, primary, Houillier, Caroline, primary, Luo, Feng R., primary, Soria, Jean-Charles, primary, Tabernero, Josep, primary, Eoli, Marica, primary, Paterra, Rosina, primary, Yip, Stephen, primary, Petrecca, Kevin, primary, Chan, Jennifer A., primary, Finocchiaro, Gaetano, primary, Lasorella, Anna, primary, Sanson, Marc, primary, and Iavarone, Antonio, primary

Published
2023
Full Text
View/download PDF

13. Supplementary Figure 3 from Detection, Characterization, and Inhibition of FGFR–TACC Fusions in IDH Wild-type Glioma

Author

Di Stefano, Anna Luisa, primary, Fucci, Alessandra, primary, Frattini, Veronique, primary, Labussiere, Marianne, primary, Mokhtari, Karima, primary, Zoppoli, Pietro, primary, Marie, Yannick, primary, Bruno, Aurelie, primary, Boisselier, Blandine, primary, Giry, Marine, primary, Savatovsky, Julien, primary, Touat, Mehdi, primary, Belaid, Hayat, primary, Kamoun, Aurelie, primary, Idbaih, Ahmed, primary, Houillier, Caroline, primary, Luo, Feng R., primary, Soria, Jean-Charles, primary, Tabernero, Josep, primary, Eoli, Marica, primary, Paterra, Rosina, primary, Yip, Stephen, primary, Petrecca, Kevin, primary, Chan, Jennifer A., primary, Finocchiaro, Gaetano, primary, Lasorella, Anna, primary, Sanson, Marc, primary, and Iavarone, Antonio, primary

Published
2023
Full Text
View/download PDF

14. Supplementary Figure 4 from Detection, Characterization, and Inhibition of FGFR–TACC Fusions in IDH Wild-type Glioma

Author

Di Stefano, Anna Luisa, primary, Fucci, Alessandra, primary, Frattini, Veronique, primary, Labussiere, Marianne, primary, Mokhtari, Karima, primary, Zoppoli, Pietro, primary, Marie, Yannick, primary, Bruno, Aurelie, primary, Boisselier, Blandine, primary, Giry, Marine, primary, Savatovsky, Julien, primary, Touat, Mehdi, primary, Belaid, Hayat, primary, Kamoun, Aurelie, primary, Idbaih, Ahmed, primary, Houillier, Caroline, primary, Luo, Feng R., primary, Soria, Jean-Charles, primary, Tabernero, Josep, primary, Eoli, Marica, primary, Paterra, Rosina, primary, Yip, Stephen, primary, Petrecca, Kevin, primary, Chan, Jennifer A., primary, Finocchiaro, Gaetano, primary, Lasorella, Anna, primary, Sanson, Marc, primary, and Iavarone, Antonio, primary

Published
2023
Full Text
View/download PDF

15. Supplementary Table 1 from Detection, Characterization, and Inhibition of FGFR–TACC Fusions in IDH Wild-type Glioma

Author

Di Stefano, Anna Luisa, primary, Fucci, Alessandra, primary, Frattini, Veronique, primary, Labussiere, Marianne, primary, Mokhtari, Karima, primary, Zoppoli, Pietro, primary, Marie, Yannick, primary, Bruno, Aurelie, primary, Boisselier, Blandine, primary, Giry, Marine, primary, Savatovsky, Julien, primary, Touat, Mehdi, primary, Belaid, Hayat, primary, Kamoun, Aurelie, primary, Idbaih, Ahmed, primary, Houillier, Caroline, primary, Luo, Feng R., primary, Soria, Jean-Charles, primary, Tabernero, Josep, primary, Eoli, Marica, primary, Paterra, Rosina, primary, Yip, Stephen, primary, Petrecca, Kevin, primary, Chan, Jennifer A., primary, Finocchiaro, Gaetano, primary, Lasorella, Anna, primary, Sanson, Marc, primary, and Iavarone, Antonio, primary

Published
2023
Full Text
View/download PDF

16. Revisiting anti-Hu paraneoplastic autoimmunity: phenotypic characterization and cancer diagnosis.

Author

Villagrán-García, Macarena, Farina, Antonio, Muñiz-Castrillo, Sergio, Wucher, Valentin, Dhairi, Maroua, Timestit, Noémie, Ciano-Petersen, Nicolás Lundahl, Vogrig, Alberto, Picard, Géraldine, Benaiteau, Marie, Psimaras, Dimitri, Petrova, Ani Valentinova, Alberto, Tifanie, Aupy, Jérôme, Giry, Marine, Rogemond, Véronique, Desestret, Virginie, Joubert, Bastien, and Honnorat, Jérôme

Published
2023
Full Text
View/download PDF

17. In Vivo 2-Hydroxyglutarate Monitoring With Edited MR Spectroscopy for the Follow-up of IDH-Mutant Diffuse Gliomas

Author

Di Stefano, Anna Luisa, primary, Nichelli, Lucia, additional, Berzero, Giulia, additional, Valabregue, Romain, additional, Touat, Mehdi, additional, Capelle, Laurent, additional, Pontoizeau, Clément, additional, Bielle, Franck, additional, Lerond, Julie, additional, Giry, Marine, additional, Villa, Chiara, additional, Baussart, Bertrand, additional, Dehais, Caroline, additional, Galanaud, Damien, additional, Baldini, Capucine, additional, Savatovsky, Julien, additional, Dhermain, Frédéric, additional, Deelchand, Dinesh K., additional, Ottolenghi, Chris, additional, Lehéricy, Stéphane, additional, Marjańska, Małgorzata, additional, Branzoli, Francesca, additional, and Sanson, Marc, additional

Published
2023
Full Text
View/download PDF

19. Tumor cells with neuronal intermediate progenitor features define a subgroup of 1p/19q co‐deleted anaplastic gliomas

Author

Bielle, Franck, Ducray, François, Mokhtari, Karima, Dehais, Caroline, Adle‐Biassette, Homa, Carpentier, Catherine, Chanut, Anaïs, Polivka, Marc, Poggioli, Sylvie, Rosenberg, Shai, Giry, Marine, Marie, Yannick, Duyckaerts, Charles, Sanson, Marc, Figarella‐Branger, Dominique, Idbaih, Ahmed, Desenclos, Christine, Sevestre, Henri, Menei, Philippe, Rousseau, Audrey, Godard, Joel, Viennet, Gabriel, Carpentier, Antoine, Eimer, Sandrine, Loiseau, Hugues, Dam‐Hieu, Phong, Quintin‐Roué, Isabelle, Guillamo, Jean‐Sebastien, Lechapt‐Zalcman, Emmanuelle, Kemeny, Jean‐Louis, Khallil, Toufik, Cazals‐Hatem, Dominique, Faillot, Thierry, Carpiuc, Ioana, Richard, Pomone, Le Guerinel, Caroline, Gaultier, Claude, Tortel, Marie‐Christine, Aubriot‐Lorton, Marie‐Hélène, Ghiringhelli, François, Adam, Clovis, Parker, Fabrice, Maurage, Claude‐Alain, Ramirez, Carole, Marcel Gueye, Edouard, Labrousse, François, Jouvet, Anne, Chinot, Olivier, Bauchet, Luc, Rigau, Valérie, Beauchesne, Patrick, Gauchotte, Guillaume, Campone, Mario, Loussouarn, Delphine, Fontaine, Denys, Vandenbos, Fanny, Blechet, Claire, Fesneau, Mélanie, Yves Delattre, Jean, Elouadhani‐Hamdi, Selma, Ricard, Damien, Larrieu‐Ciron, Delphine, Levillain, Pierre‐Marie, Colin, Philippe, Diebold, Marie‐Danièle, Chiforeanu, Danchristian, Vauléon, Elodie, Langlois, Olivier, Laquerrière, Annie, Motsuo Fotso, Marie Janette, Peocʼh, Michel, Andraud, Marie, Runavot, Gwenaelle, Chenard, Marie‐Pierre, Noel, Georges, Gaillard, Stéphane, Villa, Chiara, Desse, Nicolas, Cohen‐Moyal, Elisabeth, Uro‐Coste, Emmanuelle, and Dhermain, Frédéric

Published
2017
Full Text
View/download PDF

23. IDH-wildtype lower-grade diffuse gliomas: the importance of histological grade and molecular assessment for prognostic stratification

Author

Berzero, Giulia, primary, Di Stefano, Anna Luisa, additional, Ronchi, Susanna, additional, Bielle, Franck, additional, Villa, Chiara, additional, Guillerm, Erell, additional, Capelle, Laurent, additional, Mathon, Bertrand, additional, Laurenge, Alice, additional, Giry, Marine, additional, Schmitt, Yohann, additional, Marie, Yannick, additional, Idbaih, Ahmed, additional, Hoang-Xuan, Khe, additional, Delattre, Jean-Yves, additional, Mokhtari, Karima, additional, and Sanson, Marc, additional

Published
2020
Full Text
View/download PDF

26. PATH-16. MOLECULAR PATHOLOGY AND CLINICAL CHARACTERISTICS OF MMR DEFICIENCY (MMRd) IN DIFFUSE GLIOMAS

Author

Touat, Mehdi, primary, Santagata, Sandro, additional, Guillerm, Erell, additional, Bi, Wenya, additional, Beuvon, Frédéric, additional, Mokhtari, Karima, additional, Giry, Marine, additional, Guegan, Justine, additional, Block, Shannon, additional, Carpentier, Alexandre, additional, Delattre, Jean-Yves, additional, Sanson, Marc, additional, Duval, Alex, additional, Beroukhim, Rameen, additional, Bandopadhayay, Pratiti, additional, Reardon, David, additional, Wen, Patrick, additional, Idbaih, Ahmed, additional, Coulet, Florence, additional, Ligon, Keith, additional, and Bielle, Franck, additional

Published
2018
Full Text
View/download PDF

27. A recurrent point mutation in PRKCA is a hallmark of chordoid gliomas

Author

Rosenberg, Shai, primary, Simeonova, Iva, additional, Bielle, Franck, additional, Verreault, Maite, additional, Bance, Bertille, additional, Le Roux, Isabelle, additional, Daniau, Mailys, additional, Nadaradjane, Arun, additional, Gleize, Vincent, additional, Paris, Sophie, additional, Marie, Yannick, additional, Giry, Marine, additional, Polivka, Marc, additional, Figarella-Branger, Dominique, additional, Aubriot-Lorton, Marie-Hélène, additional, Villa, Chiara, additional, Vasiljevic, Alexandre, additional, Lechapt-Zalcman, Emmanuèle, additional, Kalamarides, Michel, additional, Sharif, Ariane, additional, Mokhtari, Karima, additional, Pagnotta, Stefano Maria, additional, Iavarone, Antonio, additional, Lasorella, Anna, additional, Huillard, Emmanuelle, additional, and Sanson, Marc, additional

Published
2018
Full Text
View/download PDF

28. De novo and secondary anaplastic meningiomas: a study of clinical and histomolecular prognostic factors

Author

Peyre, Matthieu, primary, Gauchotte, Guillaume, additional, Giry, Marine, additional, Froehlich, Sébastien, additional, Pallud, Johan, additional, Graillon, Thomas, additional, Bielle, Franck, additional, Cazals-Hatem, Dominique, additional, Varlet, Pascale, additional, Figarella-Branger, Dominique, additional, Loiseau, Hugues, additional, and Kalamarides, Michel, additional

Published
2017
Full Text
View/download PDF

29. Tumor cells with neuronal intermediate progenitor features define a subgroup of 1p/19q co-deleted anaplastic gliomas

Author

Bielle, Charles, Ducray, François, Mokhtari, Charles, Dehais, Charles, Adle-Biassette, Homa, Carpentier, Catherine, Chanut, Charles, Polivka, Marc, Poggioli, Sylvie, Rosenberg, Shai, Giry, Marine, Marie, Yannick, Duyckaerts, Charles, Sanson, Marc, Figarella-Branger, Dominique, Idbaih, Ahmed, Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Neuropathologie [CHU Pitié Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL], Hospices Civils de Lyon (HCL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), OncoNeuroTek [Paris], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-CHU Pitié-Salpêtrière [AP-HP], Service de neurologie 2 [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hôpital Lariboisière, Université Paris Diderot - Paris 7 (UPD7)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service d'Anatomo-Cyto-Pathologie et de NeuroPathologie [Hôpital de la Timone - APHM] (ACPNP), Aix Marseille Université (AMU)- Hôpital de la Timone [CHU - APHM] (TIMONE), Centre de Recherches en Oncologie biologique et Oncopharmacologie (CRO2), Aix Marseille Université (AMU)- Hôpital de la Timone [CHU - APHM] (TIMONE)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [APHP]-Centre National de la Recherche Scientifique (CNRS), Service de Neuropathologie Raymond Escourolle [CHU Pitié Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Centre de Recherche en Cancérologie de Lyon (CRCL), Université de Lyon-Université de Lyon-Centre Léon Bérard [Lyon]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [APHP]-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [APHP]-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Lariboisière-Université Paris Diderot - Paris 7 (UPD7), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)

Subjects
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV.CAN]Life Sciences [q-bio]/Cancer
Abstract

Pola Network; International audience; The integrated diagnosis of anaplastic oligodendroglioma, IDH mutant and 1p/19q co-deleted, grade III (O3id) is a histomolecular entity that WHO 2016 classification distinguished from other diffuse gliomas by specific molecular alterations. In contrast, its cell portrait is less well known. The present study is focused on intertumor and intratumor, cell lineage-oriented, heterogeneity in O3id. Based on pathological, transcriptomic and immunophenotypic studies, a novel subgroup of newly diagnosed O3id overexpressing neuronal intermediate progenitor (NIP) genes was identified. This NIP overexpression pattern in O3id is associated with: (i) morphological and immunohistochemical similarities with embryonic subventricular zone, (ii) proliferating tumor cell subpopulation with NIP features including expression of INSM1 and no expression of SOX9, (iii) mutations in critical genes involved in NIP biology and, (iv) increased tumor necrosis. Interestingly, NIP tumor cell subpopulation increases in O3id recurrence compared with paired newly diagnosed tumors. Our results, validated in an independent cohort, emphasize intertumor and intratumor heterogeneity in O3id and identified a tumor cell subpopulation exhibiting NIP characteristics that is potentially critical in oncogenesis of O3id. A better understanding of spatial and temporal intratumor cell heterogeneity in O3id will open new therapeutic avenues overcoming resistance to current antitumor treatments.

Published
2016

30. Diffuse gliomas with FGFR3‐TACC3 fusion have characteristic histopathological and molecular features

Author

Bielle, Franck, primary, Di Stefano, Anna‐Luisa, additional, Meyronet, David, additional, Picca, Alberto, additional, Villa, Chiara, additional, Bernier, Michèle, additional, Schmitt, Yohann, additional, Giry, Marine, additional, Rousseau, Audrey, additional, Figarella‐Branger, Dominique, additional, Maurage, Claude‐Alain, additional, Uro‐Coste, Emmanuelle, additional, Lasorella, Anna, additional, Iavarone, Antonio, additional, Sanson, Marc, additional, and Mokhtari, Karima, additional

Published
2017
Full Text
View/download PDF

31. GENE-54. A NOVEL MUTATION IN PRKCA IS THE MAJOR DRIVER OF CHORDOID GLIOMAS

Author

Rosenberg, Shai, primary, Simeonova, Iva, additional, Bielle, Franck, additional, Verreault, Maite, additional, Roux, Isabelle Le, additional, Daniau, Mailys, additional, Nadaradjane, Arun, additional, Gleize, Vincent, additional, Paris, Sophie, additional, Marie, Yannick, additional, Giry, Marine, additional, Polivka, Marc, additional, Branger, Dominique Figarella, additional, Aubriot-Lorton, Marie-Hélène, additional, Villa, Chiara, additional, Vasiljevic, Alexandre, additional, Lechapt-Zalcman, Emmanuèle, additional, Kalamarides, Michel, additional, Mokhtari, Karima, additional, Pagnotta, Stefano, additional, Iavarone, Antonio, additional, Lasorella, Anna, additional, Huillard, Emmanuelle, additional, and Sanson, Marc, additional

Published
2017
Full Text
View/download PDF

32. EGFRAmplification andIDHMutations in Glioblastoma Patients of the Northeast of Morocco

Author

Senhaji, Nadia, primary, Louati, Sara, additional, Chbani, Laila, additional, El Fatemi, Hind, additional, Hammas, Nawal, additional, Mikou, Karima, additional, Maaroufi, Mustapha, additional, Benzagmout, Mohammed, additional, Boujraf, Said, additional, El Bardai, Sanae, additional, Giry, Marine, additional, Marie, Yannick, additional, Chaoui El Faiz, Mohammed, additional, Mokhtari, Karima, additional, Idbaih, Ahmed, additional, Amarti, Afaf, additional, and Bennis, Sanae, additional

Published
2017
Full Text
View/download PDF

33. Chromosome 17p Homodisomy Is Associated With Better Outcome in 1p19q Non-Codeleted and IDH-Mutated Gliomas

Author

Labussière, Marianne, primary, Rahimian, Amithys, additional, Giry, Marine, additional, Boisselier, Blandine, additional, Schmitt, Yohann, additional, Polivka, Marc, additional, Mokhtari, Karima, additional, Delattre, Jean-Yves, additional, Idbaih, Ahmed, additional, Labreche, Karim, additional, Alentorn, Agusti, additional, and Sanson, Marc, additional

Published
2016
Full Text
View/download PDF

34. Diffuse gliomas with FGFR3‐TACC3 fusion have characteristic histopathological and molecular features.

Author

Bielle, Franck, Di Stefano, Anna‐Luisa, Meyronet, David, Picca, Alberto, Villa, Chiara, Bernier, Michèle, Schmitt, Yohann, Giry, Marine, Rousseau, Audrey, Figarella‐Branger, Dominique, Maurage, Claude‐Alain, Uro‐Coste, Emmanuelle, Lasorella, Anna, Iavarone, Antonio, Sanson, Marc, and Mokhtari, Karima

Subjects
GLIOMAS, CHEMORADIOTHERAPY, HISTOPATHOLOGY, FIBROBLAST growth factor receptors, DIFFUSE large B-cell lymphomas
Abstract

Adult glioblastomas, IDH‐wildtype represent a heterogeneous group of diseases. They are resistant to conventional treatment by concomitant radiochemotherapy and carry a dismal prognosis. The discovery of oncogenic gene fusions in these tumors has led to prospective targeted treatments, but identification of these rare alterations in practice is challenging. Here, we report a series of 30 adult diffuse gliomas with an in frame FGFR3‐TACC3 oncogenic fusion (n = 27 WHO grade IV and n = 3 WHO grade II) as well as their histological and molecular features. We observed recurrent morphological features (monomorphous ovoid nuclei, nuclear palisading and thin parallel cytoplasmic processes, endocrinoid network of thin capillaries) associated with frequent microcalcifications and desmoplasia. We report a constant immunoreactivity for FGFR3, which is a valuable method for screening for the FGFR3‐TACC3 fusion with 100% sensitivity and 92% specificity. We confirmed the associated molecular features (typical genetic alterations of glioblastoma, except the absence of EGFR amplification, and an increased frequency of CDK4 and MDM2 amplifications). FGFR3 immunopositivity is a valuable tool to identify gliomas that are likely to harbor the FGFR3‐TACC3 fusion for inclusion in targeted therapeutic trials. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

36. TERT promoter mutations and rs2853669 polymorphism: prognostic impact and interactions with common alterations in glioblastomas

Author

Nencha, Umberto, primary, Rahimian, Amithys, additional, Giry, Marine, additional, Sechi, Andrea, additional, Mokhtari, Karima, additional, Polivka, Marc, additional, Schmitt, Yohann, additional, Di Stefano, Anna-Luisa, additional, Alentorn, Agusti, additional, Labussière, Marianne, additional, and Sanson, Marc, additional

Published
2015
Full Text
View/download PDF

37. Detection, Characterization, and Inhibition of FGFR–TACC Fusions in IDH Wild-type Glioma

Author

Di Stefano, Anna Luisa, primary, Fucci, Alessandra, additional, Frattini, Veronique, additional, Labussiere, Marianne, additional, Mokhtari, Karima, additional, Zoppoli, Pietro, additional, Marie, Yannick, additional, Bruno, Aurelie, additional, Boisselier, Blandine, additional, Giry, Marine, additional, Savatovsky, Julien, additional, Touat, Mehdi, additional, Belaid, Hayat, additional, Kamoun, Aurelie, additional, Idbaih, Ahmed, additional, Houillier, Caroline, additional, Luo, Feng R., additional, Soria, Jean-Charles, additional, Tabernero, Josep, additional, Eoli, Marica, additional, Paterra, Rosina, additional, Yip, Stephen, additional, Petrecca, Kevin, additional, Chan, Jennifer A., additional, Finocchiaro, Gaetano, additional, Lasorella, Anna, additional, Sanson, Marc, additional, and Iavarone, Antonio, additional

Published
2015
Full Text
View/download PDF

38. Chordoid Gliomas of the Third Ventricle Share TTF-1 Expression With Organum Vasculosum of the Lamina Terminalis

Author

Bielle, Franck, primary, Villa, Chiara, additional, Giry, Marine, additional, Bergemer-Fouquet, Anne-Marie, additional, Polivka, Marc, additional, Vasiljevic, Alexandre, additional, Aubriot-Lorton, Marie-Hélène, additional, Bernier, Michèle, additional, Lechapt-Zalcman, Emmanuèle, additional, Viennet, Gabriel, additional, Sazdovitch, Véronique, additional, Duyckaerts, Charles, additional, Sanson, Marc, additional, Figarella-Branger, Dominique, additional, and Mokhtari, Karima, additional

Published
2015
Full Text
View/download PDF

39. EGFR Amplification and IDH Mutations in Glioblastoma Patients of the Northeast of Morocco.

Author

Senhaji, Nadia, Louati, Sara, Chbani, Laila, El Fatemi, Hind, Hammas, Nawal, Mikou, Karima, Maaroufi, Mustapha, Benzagmout, Mohammed, Boujraf, Said, El Bardai, Sanae, Giry, Marine, Marie, Yannick, Chaoui El Faiz, Mohammed, Mokhtari, Karima, Idbaih, Ahmed, Amarti, Afaf, and Bennis, Sanae

Subjects
CENTRAL nervous system tumors, DIAGNOSTIC imaging, DNA, EPIDERMAL growth factor, GLIOMAS, IMMUNOHISTOCHEMISTRY, MAGNETIC resonance imaging, ACQUISITION of data, RETROSPECTIVE studies, DIAGNOSIS
Abstract

Glioblastomas are the most frequent and aggressive primary brain tumors which are expressing various evolutions, aggressiveness, and prognosis. Thus, the 2007 World Health Organization classification based solely on the histological criteria is no longer sufficient. It should be complemented by molecular analysis for a true histomolecular classification. The new 2016 WHO classification of tumors of the central nervous system uses molecular parameters in addition to histology to reclassify these tumors and reduce the interobserver variability. The aim of this study is to determine the prevalence of IDH mutations and EGFR amplifications in the population of the northeast region of Morocco and then to compare the results with other studies. Methods. IDH1 codon 132 and IDH2 codon 172 were directly sequenced and the amplification of exon 20 of EGFR gene was investigated by qPCR in 65 glioblastoma tumors diagnosed at the University Hospital of Fez between 2010 and 2014. Results. The R132H IDH1 mutation was observed in 8 of 65 tumor samples (12.31%). No mutation of IDH2 was detected. EGFR amplification was identified in 17 cases (26.15%). Conclusion. A systematic search of both histological and molecular markers should be requisite for a good diagnosis and a better management of glioblastomas. [ABSTRACT FROM AUTHOR]

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results