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2 results on '"Giridharan, Kumudhini"'

1. Increasing frailty is associated with higher prevalence and reduced recognition of delirium in older hospitalised inpatients: results of a multi-centre study

Author

Faheem, Waleed, Nandra, Taran, Richardson, Sarah, Saliu, David, Wilson, Daisy, Jackson, Thomas A., Magill, Laura, McCluskey, Lauren, Perry, Rita, Welch, Carly, Copeland, Claire, Cunningham, Emma L., Davis, Daniel, Treml, Jonathan, Pinkney, Thomas, Quinn, Terrence, Nightingale, Peter, Jelley, Benjamin, Gaunt, Victoria, Lochlainn, Mary Ni, Giridharan, Kumudhini, Alsahab, Mustafa, Makin, Stephen, Torsney, Kelli, Masoli, Jane, Ronan, Lindsay, Burton, Jenni K., Todd, Oliver, Taylor, Joanne, Willott, Ruth, Cox, Natalie, Healy, Roisin, Haddad, Nedaa, Ramakrishna, Sharan, Subhan, Zahid, Mazzoleni, Antonella, Nynaes, Olga, Crofts, Jodie, McNicholas, Emily, Baillie, Jonathan, Irwin, Sophie J., Kelly, Dominic, Leah, Eleanor, Evans, Jenny, Bowman, Mark A., Quinn, Sinead, Wilson, Joseph B., Hughes, Clare, and Moore, Emily

Subjects
Recognition, Frailty, Delirium, General Medicine, Mortality, Geriatrics and Gerontology, Gerontology
Abstract

Purpose Delirium is a neuropsychiatric disorder delineated by an acute change in cognition, attention, and consciousness. It is common, particularly in older adults, but poorly recognised. Frailty is the accumulation of deficits conferring an increased risk of adverse outcomes. We set out to determine how severity of frailty, as measured using the CFS, affected delirium rates, and recognition in hospitalised older people in the United Kingdom. Methods Adults over 65 years were included in an observational multi-centre audit across UK hospitals, two prospective rounds, and one retrospective note review. Clinical Frailty Scale (CFS), delirium status, and 30-day outcomes were recorded. Results The overall prevalence of delirium was 16.3% (483). Patients with delirium were more frail than patients without delirium (median CFS 6 vs 4). The risk of delirium was greater with increasing frailty [OR 2.9 (1.8–4.6) in CFS 4 vs 1–3; OR 12.4 (6.2–24.5) in CFS 8 vs 1–3]. Higher CFS was associated with reduced recognition of delirium (OR of 0.7 (0.3–1.9) in CFS 4 compared to 0.2 (0.1–0.7) in CFS 8). These risks were both independent of age and dementia. Conclusion We have demonstrated an incremental increase in risk of delirium with increasing frailty. This has important clinical implications, suggesting that frailty may provide a more nuanced measure of vulnerability to delirium and poor outcomes. However, the most frail patients are least likely to have their delirium diagnosed and there is a significant lack of research into the underlying pathophysiology of both of these common geriatric syndromes.

Published
2023
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2. Delirium is prevalent in older hospital inpatients and associated with adverse outcomes: results of a prospective multi-centre study on World Delirium Awareness Day.

Author

Geriatric Medicine Research Collaborative, Welch, Carly, McCluskey, Lauren, Wilson, Daisy, Chapman, George E., Jackson, Thomas A., Treml, Jonathan, Davis, Daniel, Cunningham, Emma, Copeland, Claire, Quinn, Terrence, Pinkney, Thomas, Mahida, Rahul, Nightingale, Peter, Richardson, Sarah, Todd, Oliver, Willott, Ruth, Torsney, Kelli, Ni Lochlainn, Mary, and Giridharan, Kumudhini

Subjects
DELIRIUM, LONGITUDINAL method, OLDER people, MENTAL illness, LENGTH of stay in hospitals
Abstract

Background: Delirium is a common severe neuropsychiatric condition secondary to physical illness, which predominantly affects older adults in hospital. Prior to this study, the UK point prevalence of delirium was unknown. We set out to ascertain the point prevalence of delirium across UK hospitals and how this relates to adverse outcomes.Methods: We conducted a prospective observational study across 45 UK acute care hospitals. Older adults aged 65 years and older were screened and assessed for evidence of delirium on World Delirium Awareness Day (14th March 2018). We included patients admitted within the previous 48 h, excluding critical care admissions.Results: The point prevalence of Diagnostic and Statistical Manual on Mental Disorders, Fifth Edition (DSM-5) delirium diagnosis was 14.7% (222/1507). Delirium presence was associated with higher Clinical Frailty Scale (CFS): CFS 4-6 (frail) (OR 4.80, CI 2.63-8.74), 7-9 (very frail) (OR 9.33, CI 4.79-18.17), compared to 1-3 (fit). However, higher CFS was associated with reduced delirium recognition (7-9 compared to 1-3; OR 0.16, CI 0.04-0.77). In multivariable analyses, delirium was associated with increased length of stay (+ 3.45 days, CI 1.75-5.07) and increased mortality (OR 2.43, CI 1.44-4.09) at 1 month. Screening for delirium was associated with an increased chance of recognition (OR 5.47, CI 2.67-11.21).Conclusions: Delirium is prevalent in older adults in UK hospitals but remains under-recognised. Frailty is strongly associated with the development of delirium, but delirium is less likely to be recognised in frail patients. The presence of delirium is associated with increased mortality and length of stay at one month. A national programme to increase screening has the potential to improve recognition. [ABSTRACT FROM AUTHOR]

Published
2019
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