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Backgrounds/Aims Hepatocellular carcinoma (HCC) is generally diagnosed at an advanced stage, which limits curative treatment options for these patients. Locoregional therapy (LRT) is the standard approach to bridge and downstage unresectable HCC for liver transplantation (LT). Atezolizumab-bevacizumab (atezo-bev) can induce objective responses in nearly one-third of patients; however, the role and outcomes of downstaging using atezo-bev remains unknown. Methods In this retrospective single-center study, we included consecutive patients between November 2020 and August 2023, who received atezo-bev with or without LRT and were subsequently considered for resection/LT after downstaging. Results Of the 115 patients who received atezo-bev, 12 patients (10.4%) achieved complete or partial response and were willing to undergo LT; they (age, 58.5 years; women, 17%; Barcelona Clinic Liver Cancer stage system B/C, 5/7) had received 3-12 cycles of atezo- bev, and four of them had received prior LRT. Three patients died before LT, while three were awaiting LT. Six patients underwent curative therapies: four underwent living donor LT after a median of 79.5 days (range, 54-114) following the last atezo-bev dose, one underwent deceased donor LT 38 days after the last dose, and one underwent resection. All but one patient had complete pathologic response with no viable HCC. Three patients experienced wound healing complications, and one required re-exploration and succumbed to sepsis. After a median follow-up of 10 months (range, 4-30), none of the alive patients developed HCC recurrence or graft rejection. Conclusions Surgical therapy, including LT, is possible after atezo-bev therapy in well-selected patients after downstaging.

The article examines the relationship between proactive job crafting and workplace happiness in the context of millennials associated with the Indian service sector. This study was conducted with 310 millennial employees associated with IT and ITES, telecom, and banking services. The study used self-reporting questionnaires, and the hypotheses were tested using structural equation modeling. The study highlights the nature of job crafting in a hitherto under-researched sector of the Indian economy. The findings suggest that job crafting has a positive influence on driving employee happiness. Crafting structural job resources predicted millennials' job satisfaction and work engagement. Crafting by seeking social resources and challenging demands was positively associated with commitment and engagement. The study is relevant in the wake of the coronavirus pandemic when organizations are keen to address employee happiness at work. It provides evidence from the Indian service organizations for the implications of adopting job crafting behavior at work to test the adoption of theories developed in the Anglo-Saxon cultures. [ABSTRACT FROM AUTHOR]

For hybrid electric vehicles, the batteries and the drive dc link may be at different voltages. The batteries are at low voltage to obtain higher volumetric efficiencies, and the dc link is at higher voltage to have higher efficiency on the motor side. Therefore, a power interface between the batteries and the drive's dc link is essential. This power interface should handle power flow from battery to motor, motor to battery, external genset to battery, and grid to battery. This paper proposes a multi-power-port topology which is capable of handling multiple power sources and still maintains simplicity and features like obtaining high gain, wide load variations, lower output-current ripple, and capability of parallel-battery energy due to the modular structure. The scheme incorporates a transformer winding technique which drastically reduces the leakage inductance of the coupled inductor. The development and testing of a bidirectional flyback dc-dc converter for hybrid electric vehicle is described in this paper. Simple hysteresis voltage control is used for dc-link voltage regulation. The experimental results are presented to show the working of the proposed converter. Index Terms--Bidirectional flyback converter, hybrid electric vehicle, leakage inductance.