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1. The genomic and evolutionary landscapes of anaplastic thyroid carcinoma

Author

Zeng, Peter YF, Prokopec, Stephenie D, Lai, Stephen Y, Pinto, Nicole, Chan-Seng-Yue, Michelle A, Clifton-Bligh, Roderick, Williams, Michelle D, Howlett, Christopher J, Plantinga, Paul, Cecchini, Matthew J, Lam, Alfred K, Siddiqui, Iram, Wang, Jianxin, Sun, Ren X, Watson, John D, Korah, Reju, Carling, Tobias, Agrawal, Nishant, Cipriani, Nicole, Ball, Douglas, Nelkin, Barry, Rooper, Lisa M, Bishop, Justin A, Garnis, Cathie, Berean, Ken, Nicolson, Norman G, Weinberger, Paul, Henderson, Ying C, Lalansingh, Christopher M, Tian, Mao, Yamaguchi, Takafumi N, Livingstone, Julie, Salcedo, Adriana, Patel, Krupal, Vizeacoumar, Frederick, Datti, Alessandro, Xi, Liu, Nikiforov, Yuri E, Smallridge, Robert, Copland, John A, Marlow, Laura A, Hyrcza, Martin D, Delbridge, Leigh, Sidhu, Stan, Sywak, Mark, Robinson, Bruce, Fung, Kevin, Ghasemi, Farhad, Kwan, Keith, MacNeil, S Danielle, Mendez, Adrian, Palma, David A, Khan, Mohammed I, Shaikh, Mushfiq, Ruicci, Kara M, Wehrli, Bret, Winquist, Eric, Yoo, John, Mymryk, Joe S, Rocco, James W, Wheeler, David, Scherer, Steve, Giordano, Thomas J, Barrett, John W, Faquin, William C, Gill, Anthony J, Clayman, Gary, Boutros, Paul C, and Nichols, Anthony C

Subjects
Biological Sciences, Genetics, Human Genome, Cancer, Rare Diseases, Aetiology, 2.1 Biological and endogenous factors, Humans, Thyroid Carcinoma, Anaplastic, Thyroid Neoplasms, Mutation, Adenocarcinoma, Genomics, CP: Cancer, CP: Genomics, anaplastic thyroid cancer, cancer progression, genomics, tumour evolution, tumour heterogeneity, Biochemistry and Cell Biology, Medical Physiology, Biological sciences
Abstract

Anaplastic thyroid carcinoma is arguably the most lethal human malignancy. It often co-occurs with differentiated thyroid cancers, yet the molecular origins of its aggressivity are unknown. We sequenced tumor DNA from 329 regions of thyroid cancer, including 213 from patients with primary anaplastic thyroid carcinomas. We also whole genome sequenced 9 patients using multi-region sequencing of both differentiated and anaplastic thyroid cancer components. Using these data, we demonstrate thatanaplastic thyroid carcinomas have a higher burden of mutations than other thyroid cancers, with distinct mutational signatures and molecular subtypes. Further, different cancer driver genes are mutated in anaplastic and differentiated thyroid carcinomas, even those arising in a single patient. Finally, we unambiguously demonstrate that anaplastic thyroid carcinomas share a genomic origin with co-occurring differentiated carcinomas and emerge from a common malignant field through acquisition of characteristic clonal driver mutations.

Published
2024

2. Somatic SLC30A1 mutations altering zinc transporter ZnT1 cause aldosterone-producing adenomas and primary aldosteronism

Author

Rege, Juilee, Bandulik, Sascha, Nanba, Kazutaka, Kosmann, Carla, Blinder, Amy R., Plain, Allein, Vats, Pankaj, Kumar-Sinha, Chandan, Lerario, Antonio M., Else, Tobias, Yamazaki, Yuto, Satoh, Fumitoshi, Sasano, Hironobu, Giordano, Thomas J., Williams, Tracy Ann, Reincke, Martin, Turcu, Adina F., Udager, Aaron M., Warth, Richard, and Rainey, William E.

Published
2023
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3. Senescence-induced immune remodeling facilitates metastatic adrenal cancer in a sex-dimorphic manner

Author

Warde, Kate M., Smith, Lorenzo J., Liu, Lihua, Stubben, Chris J., Lohman, Brian K., Willett, Parker W., Ammer, Julia L., Castaneda-Hernandez, Guadalupe, Imodoye, Sikiru O., Zhang, Chenge, Jones, Kara D., Converso-Baran, Kimber, Ekiz, H. Atakan, Barry, Marc, Clay, Michael R., Kiseljak-Vassiliades, Katja, Giordano, Thomas J., Hammer, Gary D., and Basham, Kaitlin J.

Published
2023
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4. Single-cell analyses of renal cell cancers reveal insights into tumor microenvironment, cell of origin, and therapy response

Author

Zhang, Yuping, Narayanan, Sathiya P., Mannan, Rahul, Raskind, Gregory, Wang, Xiaoming, Vats, Pankaj, Su, Fengyun, Hosseini, Noshad, Cao, Xuhong, Kumar-Sinha, Chandan, Ellison, Stephanie J., Giordano, Thomas J., Morgan, Todd M., Pitchiaya, Sethuramasundaram, Alva, Ajjai, Mehra, Rohit, Cieslik, Marcin, Dhanasekaran, Saravana M., and Chinnaiyan, Arul M.

Published
2021

5. Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma

Author

Fishbein, Lauren, Leshchiner, Ignaty, Walter, Vonn, Danilova, Ludmila, Robertson, A Gordon, Johnson, Amy R, Lichtenberg, Tara M, Murray, Bradley A, Ghayee, Hans K, Else, Tobias, Ling, Shiyun, Jefferys, Stuart R, de Cubas, Aguirre A, Wenz, Brandon, Korpershoek, Esther, Amelio, Antonio L, Makowski, Liza, Rathmell, W Kimryn, Gimenez-Roqueplo, Anne-Paule, Giordano, Thomas J, L., Sylvia, Tischler, Arthur S, Network, The Cancer Genome Atlas Research, Akbani, Rehan, Ally, Adrian, Amar, Laurence, Arachchi, Harindra, Auchus, Richard J, Auman, J Todd, Baertsch, Robert, Balasundaram, Miruna, Balu, Saianand, Bartsch, Detlef K, Baudin, Eric, Bauer, Thomas, Beaver, Allison, Benz, Christopher, Beroukhim, Rameen, Beuschlein, Felix, Bodenheimer, Tom, Boice, Lori, Bowen, Jay, Bowlby, Reanne, Brooks, Denise, Carlsen, Rebecca, Carter, Suzie, Cassol, Clarissa A, Cherniack, Andrew D, Chin, Lynda, Cho, Juok, Chuah, Eric, Chudamani, Sudha, Cope, Leslie, Crain, Daniel, Curley, Erin, de Krijger, Ronald R, Demchok, John A, Deutschbein, Timo, Dhalla, Noreen, Dimmock, David, Dinjens, Winand NM, Eng, Charis, Eschbacher, Jennifer, Fassnacht, Martin, Felau, Ina, Feldman, Michael, Ferguson, Martin L, Fiddes, Ian, Frazer, Scott, Gabriel, Stacey B, Gardner, Johanna, Gastier-Foster, Julie M, Gehlenborg, Nils, Gerken, Mark, Getz, Gad, Geurts, Jennifer, Goldman, Mary, Graim, Kiley, Gupta, Manaswi, Haan, David, Hahner, Stefanie, Hantel, Constanze, Haussler, David, Hayes, D Neil, Heiman, David I, Hoadley, Katherine A, Holt, Robert A, Hoyle, Alan P, Huang, Mei, Hunt, Bryan, and Hutter, Carolyn M

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Neurosciences, Precision Medicine, Cancer, Human Genome, Cancer Genomics, Biotechnology, Rare Diseases, 2.1 Biological and endogenous factors, Aetiology, Good Health and Well Being, Adult, Aged, Aged, 80 and over, DNA-Binding Proteins, Female, Gene Fusion, Humans, Male, Middle Aged, Mutation, Nuclear Proteins, Paraganglioma, Pheochromocytoma, Pol1 Transcription Initiation Complex Proteins, Proto-Oncogene Proteins c-ret, RNA-Binding Proteins, Trans-Activators, Transcription Factors, Cancer Genome Atlas Research Network, CSDE1, MAML3, TCGA, expression subtypes, genomics, metastasis, molecular profiling, paraganglioma, pheochromocytoma, sequencing, Oncology and Carcinogenesis, Oncology & Carcinogenesis, Biochemistry and cell biology, Oncology and carcinogenesis
Abstract

We report a comprehensive molecular characterization of pheochromocytomas and paragangliomas (PCCs/PGLs), a rare tumor type. Multi-platform integration revealed that PCCs/PGLs are driven by diverse alterations affecting multiple genes and pathways. Pathogenic germline mutations occurred in eight PCC/PGL susceptibility genes. We identified CSDE1 as a somatically mutated driver gene, complementing four known drivers (HRAS, RET, EPAS1, and NF1). We also discovered fusion genes in PCCs/PGLs, involving MAML3, BRAF, NGFR, and NF1. Integrated analysis classified PCCs/PGLs into four molecularly defined groups: a kinase signaling subtype, a pseudohypoxia subtype, a Wnt-altered subtype, driven by MAML3 and CSDE1, and a cortical admixture subtype. Correlates of metastatic PCCs/PGLs included the MAML3 fusion gene. This integrated molecular characterization provides a comprehensive foundation for developing PCC/PGL precision medicine.

Published
2017

8. Multi-Institutional Prospective Validation of Prognostic mRNA Signatures in Early Stage Squamous Lung Cancer (Alliance)

Author

Bueno, Raphael, Richards, William G., Harpole, David H., Ballman, Karla V., Tsao, Ming-Sound, Chen, Zhengming, Wang, Xiaofei, Chen, Guoan, Chirieac, Lucian R., Chui, M. Herman, Franklin, Wilbur A., Giordano, Thomas J., Govindan, Ramaswamy, Joshi, Mary-Beth, Merrick, Daniel T., Rivard, Christopher J., Sporn, Thomas, van Bokhoven, Adrie, Yu, Hui, Shepherd, Frances A., Watson, Mark A., Beer, David G., and Hirsch, Fred R.

Published
2020
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10. Nomenclature Revision for Encapsulated Follicular Variant of Papillary Thyroid Carcinoma: A Paradigm Shift to Reduce Overtreatment of Indolent Tumors

Author

Nikiforov, Yuri E, Seethala, Raja R, Tallini, Giovanni, Baloch, Zubair W, Basolo, Fulvio, Thompson, Lester DR, Barletta, Justine A, Wenig, Bruce M, Al Ghuzlan, Abir, Kakudo, Kennichi, Giordano, Thomas J, Alves, Venancio A, Khanafshar, Elham, L., Sylvia, El-Naggar, Adel K, Gooding, William E, Hodak, Steven P, Lloyd, Ricardo V, Maytal, Guy, Mete, Ozgur, Nikiforova, Marina N, Nosé, Vania, Papotti, Mauro, Poller, David N, Sadow, Peter M, Tischler, Arthur S, Tuttle, R Michael, Wall, Kathryn B, LiVolsi, Virginia A, Randolph, Gregory W, and Ghossein, Ronald A

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Rare Diseases, Patient Safety, Cancer, Clinical Research, Adenocarcinoma, Follicular, Adult, Aged, Aged, 80 and over, Carcinoma, Carcinoma, Papillary, Female, Humans, Male, Medical Overuse, Middle Aged, Neoplasm Invasiveness, Retrospective Studies, Terminology as Topic, Thyroid Cancer, Papillary, Thyroid Neoplasms, Thyroid Nodule, Young Adult, Public Health and Health Services, Oncology and carcinogenesis
Abstract

ImportanceAlthough growing evidence points to highly indolent behavior of encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC), most patients with EFVPTC are treated as having conventional thyroid cancer.ObjectiveTo evaluate clinical outcomes, refine diagnostic criteria, and develop a nomenclature that appropriately reflects the biological and clinical characteristics of EFVPTC.Design, setting, and participantsInternational, multidisciplinary, retrospective study of patients with thyroid nodules diagnosed as EFVPTC, including 109 patients with noninvasive EFVPTC observed for 10 to 26 years and 101 patients with invasive EFVPTC observed for 1 to 18 years. Review of digitized histologic slides collected at 13 sites in 5 countries by 24 thyroid pathologists from 7 countries. A series of teleconferences and a face-to-face conference were used to establish consensus diagnostic criteria and develop new nomenclature.Main outcomes and measuresFrequency of adverse outcomes, including death from disease, distant or locoregional metastases, and structural or biochemical recurrence, in patients with noninvasive and invasive EFVPTC diagnosed on the basis of a set of reproducible histopathologic criteria.ResultsConsensus diagnostic criteria for EFVPTC were developed by 24 thyroid pathologists. All of the 109 patients with noninvasive EFVPTC (67 treated with only lobectomy, none received radioactive iodine ablation) were alive with no evidence of disease at final follow-up (median [range], 13 [10-26] years). An adverse event was seen in 12 of 101 (12%) of the cases of invasive EFVPTC, including 5 patients developing distant metastases, 2 of whom died of disease. Based on the outcome information for noninvasive EFVPTC, the name "noninvasive follicular thyroid neoplasm with papillary-like nuclear features" (NIFTP) was adopted. A simplified diagnostic nuclear scoring scheme was developed and validated, yielding a sensitivity of 98.6% (95% CI, 96.3%-99.4%), specificity of 90.1% (95% CI, 86.0%-93.1%), and overall classification accuracy of 94.3% (95% CI, 92.1%-96.0%) for NIFTP.Conclusions and relevanceThyroid tumors currently diagnosed as noninvasive EFVPTC have a very low risk of adverse outcome and should be termed NIFTP. This reclassification will affect a large population of patients worldwide and result in a significant reduction in psychological and clinical consequences associated with the diagnosis of cancer.

Published
2016

11. Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma

Author

Zheng, Siyuan, Cherniack, Andrew D, Dewal, Ninad, Moffitt, Richard A, Danilova, Ludmila, Murray, Bradley A, Lerario, Antonio M, Else, Tobias, Knijnenburg, Theo A, Ciriello, Giovanni, Kim, Seungchan, Assie, Guillaume, Morozova, Olena, Akbani, Rehan, Shih, Juliann, Hoadley, Katherine A, Choueiri, Toni K, Waldmann, Jens, Mete, Ozgur, Robertson, A Gordon, Wu, Hsin-Ta, Raphael, Benjamin J, Shao, Lina, Meyerson, Matthew, Demeure, Michael J, Beuschlein, Felix, Gill, Anthony J, Sidhu, Stan B, Almeida, Madson Q, Fragoso, Maria CBV, Cope, Leslie M, Kebebew, Electron, Habra, Mouhammed A, Whitsett, Timothy G, Bussey, Kimberly J, Rainey, William E, L., Sylvia, Bertherat, Jérôme, Fassnacht, Martin, Wheeler, David A, Network, The Cancer Genome Atlas Research, Verhaak, Roel GW, Giordano, Thomas J, Hammer, Gary D, Assié, Guillaume, Wu, Hsin-Tu, Almeida, Madson, Fragoso, Maria Candida Barisson, Habra, Mouhammed Amir, Benz, Christopher, Ally, Adrian, Balasundaram, Miruna, Bowlby, Reanne, Brooks, Denise, Butterfield, Yaron SN, Carlsen, Rebecca, Dhalla, Noreen, Guin, Ranabir, Holt, Robert A, Jones, Steven JM, Kasaian, Katayoon, Lee, Darlene, Li, Haiyan I, Lim, Lynette, Ma, Yussanne, and Marra, Marco A

Subjects
Biological Sciences, Bioinformatics and Computational Biology, Biomedical and Clinical Sciences, Genetics, Human Genome, Cancer, Rare Diseases, Biotechnology, Clinical Research, Adolescent, Adrenal Cortex Neoplasms, Adrenocortical Carcinoma, Adult, Aged, Aged, 80 and over, Child, DNA Methylation, Disease-Free Survival, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Genetic Predisposition to Disease, Genome, Human, Genomics, Humans, Male, Middle Aged, Mutation, Outcome Assessment, Health Care, Prognosis, Young Adult, Cancer Genome Atlas Research Network, Neurosciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis, Biochemistry and cell biology, Oncology and carcinogenesis
Abstract

We describe a comprehensive genomic characterization of adrenocortical carcinoma (ACC). Using this dataset, we expand the catalogue of known ACC driver genes to include PRKAR1A, RPL22, TERF2, CCNE1, and NF1. Genome wide DNA copy-number analysis revealed frequent occurrence of massive DNA loss followed by whole-genome doubling (WGD), which was associated with aggressive clinical course, suggesting WGD is a hallmark of disease progression. Corroborating this hypothesis were increased TERT expression, decreased telomere length, and activation of cell-cycle programs. Integrated subtype analysis identified three ACC subtypes with distinct clinical outcome and molecular alterations which could be captured by a 68-CpG probe DNA-methylation signature, proposing a strategy for clinical stratification of patients based on molecular markers.

Published
2016

12. Contributors

Author

Abraham, Devaprabu, primary, Abraham, Nikita R., additional, Agarwal, Amit, additional, Ahadi, Mahsa S., additional, Alameer, Ehab, additional, Alobuia, Wilson, additional, Alon, Eran E., additional, Angkoon, Anuwong, additional, Al-Qurayshi, Zaid, additional, Angell, Trevor E., additional, Angelos, Peter, additional, Baek, Jung Hwan, additional, Baloch, Zubair W., additional, Barczyński, Marcin, additional, Bauer, Andrew J., additional, Bellantone, Rocco, additional, Berdelou, Amandine, additional, Bergenfeltz, Anders, additional, Bernet, Victor J., additional, Bible, Keith C., additional, Bilezikian, John Paul, additional, Bonilla-Velez, Juliana, additional, Boucai, Laura, additional, Brent, Gregory A., additional, Breuskin, Ingrid, additional, Brierley, James Duncan, additional, Brisebois, Simon, additional, Brooks, Jennifer, additional, Brumund, Kevin T., additional, Bura, Mijenko, additional, Alvarez, Jean Gabriel Bustamante, additional, Carneiro-Pla, Denise, additional, Cernea, Claudio R., additional, Chang, Rita Yuk-kwan, additional, Chen, Amy, additional, Chiang, Feng-Yu, additional, Chintakuntlawar, Ashish V., additional, Cho, Nancy L., additional, Chung, Woong Youn, additional, Cibas, Edmund S., additional, Dacey, Carolyn, additional, Davies, Louise, additional, De Crea, Carmela, additional, Delbridge, Leigh, additional, Diercks, Gillian, additional, Doherty, Gerard M., additional, Dralle, Henning, additional, Duh, Quan-Yang, additional, Dunlap, Quinn Alexander, additional, Durante, Cosmio, additional, Eltelety, Ahmad Mohamed, additional, Evans, Douglas B., additional, Fadda, Guido, additional, Faquin, William C., additional, Felger, Erin, additional, Ferris, Robert L., additional, Filetti, Sebastiano, additional, Freeman, Jeremy L., additional, Fundakowski, Christopher, additional, Ganly, Ian, additional, Gigliotti, Benjamin Joseph, additional, Gill, Anthony J., additional, Giordano, Thomas J., additional, Giuliani, Meredith E., additional, Gooi, Zhen, additional, Gopal, Raj K., additional, Guerlain, Joanne, additional, Hadoux, Julien, additional, Hales, Nathan, additional, Hartl, Dana, additional, Haugen, Bryan R., additional, Haymart, Megan R., additional, Inabnet, William B., additional, Irish, Jonathan, additional, Iwata, Ayaka, additional, Kamani, Dipti, additional, Kandil, Emad, additional, Kaplan, Edwin L., additional, Kazahaya, Ken, additional, Kebebew, Electron, additional, Kim, Matthew I., additional, Kovatch, Kevin J., additional, Lang, Brian H.H., additional, Leboulleux, Sophie, additional, Leung, Angela M., additional, Levine, Robert A., additional, Liddy, Whitney, additional, LiVolsi, Virginia A., additional, Lombardi, Celestino Pio, additional, Lubitz, Carrie C., additional, Machens, Andreas, additional, Maghami, Ellie, additional, Mandel, Susan J., additional, Maniakas, Anastasios, additional, Mathisen, Douglas J., additional, Mathur, Aarti, additional, Merati, Albert, additional, Milas, Mira, additional, Miyauchi, Akira, additional, Monteiro, Eric, additional, Netterville, James L., additional, Nikiforov, Yuri E., additional, Orloff, Lisa A., additional, Pandian, T.K., additional, Parangi, Sareh, additional, Parikh, Sanjay, additional, Park, Auh Whan, additional, Pearce, Elizabeth N., additional, Pellitteri, Phillip K., additional, Pennestrì, Francesco, additional, Pradhan, Roma, additional, Prichard, Ruth, additional, Raffaelli, Marco, additional, Randolph, Gregory W., additional, Rastatter, Jeff, additional, Reid, Lisa M., additional, Richer, Sara L., additional, Richmon, Jeremy D., additional, Ringel, Matthew D., additional, Roman, Benjamin R., additional, Romanchishen, Anatoly F., additional, Ross, Douglas S., additional, Russell, Jonathon O., additional, Russell, Marika D., additional, Ryder, Mabel, additional, Sabra, Mona M., additional, Sachdeva, Uma M., additional, Sadow, Peter M., additional, Scharpf, Joseph, additional, Schlumberger, Martin, additional, Schneider, Rick, additional, Scott-Coombes, David, additional, Sewell, Andrew B., additional, Shah, Jatin, additional, Shah, Manisha H., additional, Shindo, Maisie, additional, Shonka, David, additional, Silverberg, Shonni Joy, additional, Sims, John Randall, additional, Sinclair, Catherine F., additional, Singer, Michael C., additional, Siperstein, Allan E., additional, Sipos, Jennifer A., additional, Slough, Cristian Martin, additional, Sosa, Julie A., additional, Soylu, Selen, additional, Stack, Brendan C., additional, Stathatos, Nikolaos, additional, Stechman, Michael James, additional, Stephen, Antonia E., additional, Steward, David L., additional, Suh, Hyun, additional, Sywak, Mark, additional, Tang, Alice, additional, Terris, David J., additional, Thompson, Geoffrey Bruce, additional, Tolley, Neil, additional, Tominaga, Yoshihiro, additional, Triponez, Frédéric, additional, Tsang, Richard W., additional, Tuttle, R. Michael, additional, Urken, Mark L., additional, Vabalayte, Kristina V., additional, Vahabzadeh-Hagh, Andrew M., additional, Volpi, Erivelto Martinho, additional, Wang, Tracy S., additional, Wu, Che-Wei, additional, Wirth, Lori J., additional, Witterick, Ian, additional, Wong, Richard J., additional, Woodson, Gayle E., additional, Wright, Cameron D., additional, Zafereo, Mark E., additional, and Zubiaur, Fermin M., additional

Published
2021
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16. FRI137 Histologic And Genetic Characteristics Of Primary Aldosteronism In Late Adulthood

Author

Blinder, Amy, primary, Nanba, Kazutaka, additional, Sapiro, Dina, additional, Baker, Jessica, additional, Liu, Chia-Jen, additional, Bancos, Irina, additional, Lyden, Melanie, additional, Young, William, additional, Wachtel, Heather, additional, Cohen, Debbie, additional, Luther, James, additional, Ann Williams, Tracy, additional, Reincke, Martin, additional, Else, Tobias, additional, Giordano, Thomas J, additional, Udager, Aaron, additional, and Rainey, William E, additional

Published
2023
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17. OR02-01 Somatic Mutations In The Zinc Transporter ZnT1 Cause Primary Aldosteronism

Author

Rege, Juilee, primary, Bandulik, Sascha, additional, Nanba, Kazutaka, additional, Kosmann, Carla, additional, Blinder, Amy, additional, Plain, Allen, additional, Vats, Pankaj, additional, Kumar-Sinha, Chandan, additional, Marcondes Lerario, Antonio, additional, Else, Tobias, additional, Yamazaki, Yuto, additional, Satoh, Fumitoshi, additional, Sasano, Hironobu, additional, Giordano, Thomas J, additional, Ann Williams, Tracy, additional, Reincke, Martin, additional, Turcu, Adina, additional, Udager, Aaron, additional, Warth, Richard, additional, and Rainey, William E, additional

Published
2023
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20. Supplementary Data from β-Catenin–Driven Differentiation Is a Tissue-Specific Epigenetic Vulnerability in Adrenal Cancer

Author

Mohan, Dipika R., primary, Borges, Kleiton S., primary, Finco, Isabella, primary, LaPensee, Christopher R., primary, Rege, Juilee, primary, Solon, April L., primary, Little, Donald W., primary, Else, Tobias, primary, Almeida, Madson Q., primary, Dang, Derek, primary, Haggerty-Skeans, James, primary, Apfelbaum, April A., primary, Vinco, Michelle, primary, Wakamatsu, Alda, primary, Mariani, Beatriz M.P., primary, Amorim, Larissa Costa, primary, Latronico, Ana Claudia, primary, Mendonca, Berenice B., primary, Zerbini, Maria Claudia N., primary, Lawlor, Elizabeth R., primary, Ohi, Ryoma, primary, Auchus, Richard J., primary, Rainey, William E., primary, Marie, Suely K.N., primary, Giordano, Thomas J., primary, Venneti, Sriram, primary, Fragoso, Maria Candida Barisson Villares, primary, Breault, David T., primary, Lerario, Antonio Marcondes, primary, and Hammer, Gary D., primary

Published
2023
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21. Data from β-Catenin–Driven Differentiation Is a Tissue-Specific Epigenetic Vulnerability in Adrenal Cancer

Author

Mohan, Dipika R., primary, Borges, Kleiton S., primary, Finco, Isabella, primary, LaPensee, Christopher R., primary, Rege, Juilee, primary, Solon, April L., primary, Little, Donald W., primary, Else, Tobias, primary, Almeida, Madson Q., primary, Dang, Derek, primary, Haggerty-Skeans, James, primary, Apfelbaum, April A., primary, Vinco, Michelle, primary, Wakamatsu, Alda, primary, Mariani, Beatriz M.P., primary, Amorim, Larissa Costa, primary, Latronico, Ana Claudia, primary, Mendonca, Berenice B., primary, Zerbini, Maria Claudia N., primary, Lawlor, Elizabeth R., primary, Ohi, Ryoma, primary, Auchus, Richard J., primary, Rainey, William E., primary, Marie, Suely K.N., primary, Giordano, Thomas J., primary, Venneti, Sriram, primary, Fragoso, Maria Candida Barisson Villares, primary, Breault, David T., primary, Lerario, Antonio Marcondes, primary, and Hammer, Gary D., primary

Published
2023
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22. Supplementary Information from β-Catenin–Driven Differentiation Is a Tissue-Specific Epigenetic Vulnerability in Adrenal Cancer

Author

Mohan, Dipika R., primary, Borges, Kleiton S., primary, Finco, Isabella, primary, LaPensee, Christopher R., primary, Rege, Juilee, primary, Solon, April L., primary, Little, Donald W., primary, Else, Tobias, primary, Almeida, Madson Q., primary, Dang, Derek, primary, Haggerty-Skeans, James, primary, Apfelbaum, April A., primary, Vinco, Michelle, primary, Wakamatsu, Alda, primary, Mariani, Beatriz M.P., primary, Amorim, Larissa Costa, primary, Latronico, Ana Claudia, primary, Mendonca, Berenice B., primary, Zerbini, Maria Claudia N., primary, Lawlor, Elizabeth R., primary, Ohi, Ryoma, primary, Auchus, Richard J., primary, Rainey, William E., primary, Marie, Suely K.N., primary, Giordano, Thomas J., primary, Venneti, Sriram, primary, Fragoso, Maria Candida Barisson Villares, primary, Breault, David T., primary, Lerario, Antonio Marcondes, primary, and Hammer, Gary D., primary

Published
2023
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23. Protein Profiles Associated with Survival in Lung Adenocarcinoma

Author

Chen, Guoan, Gharib, Tarek G., Wang, Hong, Huang, Chiang-Ching, Kuick, Rork, Thomas, Dafydd G., Shedden, Kerby A., Misek, David E., Giordano, Thomas J., Iannettoni, Mark D., Yee, John, Hogg, Philip J., Orringer, Mark B., Hanash, Samir M., and Beer, David G.

Published
2003

27. β-Catenin–Driven Differentiation Is a Tissue-Specific Epigenetic Vulnerability in Adrenal Cancer

Author

Mohan, Dipika R., primary, Borges, Kleiton S., additional, Finco, Isabella, additional, LaPensee, Christopher R., additional, Rege, Juilee, additional, Solon, April L., additional, Little, Donald W., additional, Else, Tobias, additional, Almeida, Madson Q., additional, Dang, Derek, additional, Haggerty-Skeans, James, additional, Apfelbaum, April A., additional, Vinco, Michelle, additional, Wakamatsu, Alda, additional, Mariani, Beatriz M.P., additional, Amorim, Larissa Costa, additional, Latronico, Ana Claudia, additional, Mendonca, Berenice B., additional, Zerbini, Maria Claudia N., additional, Lawlor, Elizabeth R., additional, Ohi, Ryoma, additional, Auchus, Richard J., additional, Rainey, William E., additional, Marie, Suely K.N., additional, Giordano, Thomas J., additional, Venneti, Sriram, additional, Fragoso, Maria Candida Barisson Villares, additional, Breault, David T., additional, Lerario, Antonio Marcondes, additional, and Hammer, Gary D., additional

Published
2023
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28. The genomic and evolutionary landscapes of anaplastic thyroid carcinoma

Author

Zeng, Peter YF, primary, Prokopec, Stephenie D., additional, Lai, Stephen Y., additional, Pinto, Nicole, additional, Chan-Seng-Yue, Michelle A., additional, Clifton-Bligh, Roderick, additional, Williams, Michelle D., additional, Howlett, Christopher J., additional, Plantinga, Paul, additional, Cecchini, Matthew, additional, Lam, Alfred K., additional, Siddiqui, Iram, additional, Wang, Jianxin, additional, Sun, Ren, additional, Watson, John, additional, Korah, Reju, additional, Carling, Tobias, additional, Agrawal, Nishant, additional, Cipriani, Nicole, additional, Ball, Douglas, additional, Nelkin, Barry, additional, Rooper, Lisa M., additional, Bishop, Justin A., additional, Garnis, Cathie, additional, Berean, Ken, additional, Nicolson, Norman, additional, Weinberger, Paul, additional, Henderson, Ying C., additional, Lalansingh, Christopher M., additional, Tian, Mao, additional, Yamaguchi, Takafumi, additional, Livingstone, Julie, additional, Salcedo, Adriana, additional, Patel, Krupal, additional, Vizeacoumar, Frederick, additional, Datti, Alessandro, additional, Xi, Liu, additional, Nikiforov, Yuri, additional, Smallridge, Robert, additional, Copland, John A., additional, Marlow, Laura A., additional, Hyrcza, Martin D., additional, Delbridge, Leigh, additional, Sidhu, Stan, additional, Sywak, Mark, additional, Robinson, Bruce, additional, Fung, Kevin, additional, Ghasemi, Farhad, additional, Kwan, Keith, additional, MacNeil, Danielle, additional, Mendez, Adrian, additional, Palma, David A., additional, Khan, Mohammed I., additional, Shaikh, Mushfiq, additional, Ruicci, Kara M., additional, Wehrli, Bret, additional, Winquist, Eric, additional, Yoo, John, additional, Mymryk, Joe, additional, Rocco, James W., additional, Wheeler, David, additional, Scherer, Steve, additional, Giordano, Thomas J., additional, Barrett, John W., additional, Faquin, William C., additional, Gill, Anthony J., additional, Clayman, Gary, additional, Boutros, Paul C., additional, and Nichols, Anthony C., additional

Published
2023
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29. Abstract 1501: Epigenetic dedifferentiation as a therapeutic strategy in adrenal cancer

Author

Mohan, Dipika R., primary, Borges, Kleiton S., additional, Finco, Isabella, additional, LaPensee, Christopher R., additional, Rege, Juilee, additional, Little, Donald W., additional, Else, Tobias, additional, Almeida, Madson Q., additional, Dang, Derek, additional, Haggerty-Skeans, James, additional, Latronico, Ana Claudia, additional, Mendonca, Berenice B., additional, Auchus, Richard J., additional, Rainey, William E., additional, Marie, Suely K., additional, Giordano, Thomas J., additional, Venneti, Sriram, additional, Fragoso, Maria Candida B., additional, Breault, David T., additional, Lerario, Antonio M., additional, and Hammer, Gary D., additional

Published
2023
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30. Supplemental legend from Targeted Assessment of G0S2 Methylation Identifies a Rapidly Recurrent, Routinely Fatal Molecular Subtype of Adrenocortical Carcinoma

Author

Mohan, Dipika R., primary, Lerario, Antonio Marcondes, primary, Else, Tobias, primary, Mukherjee, Bhramar, primary, Almeida, Madson Q., primary, Vinco, Michelle, primary, Rege, Juilee, primary, Mariani, Beatriz M. P., primary, Zerbini, Maria Claudia N., primary, Mendonca, Berenice B., primary, Latronico, Ana Claudia, primary, Marie, Suely K. N., primary, Rainey, William E., primary, Giordano, Thomas J., primary, Fragoso, Maria Candida B. V., primary, and Hammer, Gary D., primary

Published
2023
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31. Supplementary Figures S1-S7 from Targeted Assessment of G0S2 Methylation Identifies a Rapidly Recurrent, Routinely Fatal Molecular Subtype of Adrenocortical Carcinoma

Author

Mohan, Dipika R., primary, Lerario, Antonio Marcondes, primary, Else, Tobias, primary, Mukherjee, Bhramar, primary, Almeida, Madson Q., primary, Vinco, Michelle, primary, Rege, Juilee, primary, Mariani, Beatriz M. P., primary, Zerbini, Maria Claudia N., primary, Mendonca, Berenice B., primary, Latronico, Ana Claudia, primary, Marie, Suely K. N., primary, Rainey, William E., primary, Giordano, Thomas J., primary, Fragoso, Maria Candida B. V., primary, and Hammer, Gary D., primary

Published
2023
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33. Supplementary Data from CYP24A1 Is an Independent Prognostic Marker of Survival in Patients with Lung Adenocarcinoma

Author

Chen, Guoan, primary, Kim, So Hee, primary, King, Amanda N., primary, Zhao, Lili, primary, Simpson, Robert U., primary, Christensen, Paul J., primary, Wang, Zhuwen, primary, Thomas, Dafydd G., primary, Giordano, Thomas J., primary, Lin, Lin, primary, Brenner, Dean E., primary, Beer, David G., primary, and Ramnath, Nithya, primary

Published
2023
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34. Supplementary Table S9 from Targeted Assessment of G0S2 Methylation Identifies a Rapidly Recurrent, Routinely Fatal Molecular Subtype of Adrenocortical Carcinoma

Author

Mohan, Dipika R., primary, Lerario, Antonio Marcondes, primary, Else, Tobias, primary, Mukherjee, Bhramar, primary, Almeida, Madson Q., primary, Vinco, Michelle, primary, Rege, Juilee, primary, Mariani, Beatriz M. P., primary, Zerbini, Maria Claudia N., primary, Mendonca, Berenice B., primary, Latronico, Ana Claudia, primary, Marie, Suely K. N., primary, Rainey, William E., primary, Giordano, Thomas J., primary, Fragoso, Maria Candida B. V., primary, and Hammer, Gary D., primary

Published
2023
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36. Supplementary Tables S3, S4, S6, S7, S8 from Targeted Assessment of G0S2 Methylation Identifies a Rapidly Recurrent, Routinely Fatal Molecular Subtype of Adrenocortical Carcinoma

Author

Mohan, Dipika R., primary, Lerario, Antonio Marcondes, primary, Else, Tobias, primary, Mukherjee, Bhramar, primary, Almeida, Madson Q., primary, Vinco, Michelle, primary, Rege, Juilee, primary, Mariani, Beatriz M. P., primary, Zerbini, Maria Claudia N., primary, Mendonca, Berenice B., primary, Latronico, Ana Claudia, primary, Marie, Suely K. N., primary, Rainey, William E., primary, Giordano, Thomas J., primary, Fragoso, Maria Candida B. V., primary, and Hammer, Gary D., primary

Published
2023
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43. Supplementary Methods, Figures 1-2, Tables 1-19 from Gene Expression Patterns in Mismatch Repair-Deficient Colorectal Cancers Highlight the Potential Therapeutic Role of Inhibitors of the Phosphatidylinositol 3-Kinase-AKT-Mammalian Target of Rapamycin Pathway

Author

Vilar, Eduardo, primary, Mukherjee, Bhramar, primary, Kuick, Rork, primary, Raskin, Leon, primary, Misek, David E., primary, Taylor, Jeremy M.G., primary, Giordano, Thomas J., primary, Hanash, Samir M., primary, Fearon, Eric R., primary, Rennert, Gad, primary, and Gruber, Stephen B., primary

Published
2023
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44. Supplementary Data from Decreased Selenium-Binding Protein 1 in Esophageal Adenocarcinoma Results from Posttranscriptional and Epigenetic Regulation and Affects Chemosensitivity

Author

Silvers, Amy L., primary, Lin, Lin, primary, Bass, Adam J., primary, Chen, Guoan, primary, Wang, Zhuwen, primary, Thomas, Dafydd G., primary, Lin, Jules, primary, Giordano, Thomas J., primary, Orringer, Mark B., primary, Beer, David G., primary, and Chang, Andrew C., primary

Published
2023
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45. Supplementary Methods, Tables 1-4, Figures 1-7 from Gene Expression Differences between Colon and Rectum Tumors

Author

Sanz-Pamplona, Rebeca, primary, Cordero, David, primary, Berenguer, Antonio, primary, Lejbkowicz, Flavio, primary, Rennert, Hedy, primary, Salazar, Ramon, primary, Biondo, Sebastiano, primary, Sanjuan, Xavier, primary, Pujana, Miguel A., primary, Rozek, Laura, primary, Giordano, Thomas J., primary, Ben-Izhak, Ofer, primary, Cohen, Hector I., primary, Trougouboff, Philip, primary, Bejhar, Jacob, primary, Sova, Yanina, primary, Rennert, Gad, primary, Gruber, Stephen B., primary, and Moreno, Victor, primary

Published
2023
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49. Supplementary Table 5 from Autoantibody Profiles Reveal Ubiquilin 1 as a Humoral Immune Response Target in Lung Adenocarcinoma

Author

Chen, Guoan, primary, Wang, Xiaoju, primary, Yu, Jianjun, primary, Varambally, Sooryanarayana, primary, Yu, Jindan, primary, Thomas, Dafydd G., primary, Lin, Mu-Yen, primary, Vishnu, Prakash, primary, Wang, Zhuwen, primary, Wang, Rui, primary, Fielhauer, Jeff, primary, Ghosh, Debashis, primary, Giordano, Thomas J., primary, Giacherio, Donald, primary, Chang, Andrew C., primary, Orringer, Mark B., primary, El-Hefnawy, Talal, primary, Bigbee, William L., primary, Beer, David G., primary, and Chinnaiyan, Arul M., primary

Published
2023
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50. Supplementary Data from Autoantibody Profiles Reveal Ubiquilin 1 as a Humoral Immune Response Target in Lung Adenocarcinoma

Author

Chen, Guoan, primary, Wang, Xiaoju, primary, Yu, Jianjun, primary, Varambally, Sooryanarayana, primary, Yu, Jindan, primary, Thomas, Dafydd G., primary, Lin, Mu-Yen, primary, Vishnu, Prakash, primary, Wang, Zhuwen, primary, Wang, Rui, primary, Fielhauer, Jeff, primary, Ghosh, Debashis, primary, Giordano, Thomas J., primary, Giacherio, Donald, primary, Chang, Andrew C., primary, Orringer, Mark B., primary, El-Hefnawy, Talal, primary, Bigbee, William L., primary, Beer, David G., primary, and Chinnaiyan, Arul M., primary

Published
2023
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