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The herbicide atrazine (ATR) has been one of the most widely used herbicides worldwide. However, due to its indiscriminate use, it has been considered an environmental contaminant. Several studies have classified ATR as an endocrine disruptor, and it has been found to have neurotoxic effects on behavior, along with alterations in the dopaminergic, GABAergic, and glutamatergic systems in the basal ganglia of male rodents. These findings suggest that these neurotransmitter systems are targets of this herbicide. However, there are no studies evaluating the neurotoxicity of ATR in female rodents. Our study aimed to assess the effects of repeated IP injections of 100 mg ATR/kg or a vehicle every other day for 2 weeks (six injections) on the locomotor activity, content of monoamines, GABA, glutamate, and glutamine in the striatum, nucleus accumbens, ventral midbrain, and prefrontal cortex, and tyrosine hydroxylase (TH) protein levels in striatum and nucleus accumbens of female rats. Repeated 100 mg ATR/kg injections immediately decreased all the locomotor activity parameters evaluated, and such hypoactivity persisted for at least 48 h after the last ATR administration. The ATR administration increased dopamine and DOPAC content in the nucleus accumbens and the dopamine and DOPAC and serotonin and 5-HIAA content in the ventral midbrain. In contrast, the TH protein levels in the striatum and nucleus accumbens were similar between groups. Meanwhile, GABA, glutamine, and glutamate levels remained unaltered in all brain regions evaluated. The observed behavioral alterations could be associated with the monoamine changes presented by the rats. These data reveal that the nucleus accumbens and ventral midbrain are susceptible to repeated ATR exposure in female rats. [ABSTRACT FROM AUTHOR]

Philosophers of history posit a class of concepts known as colligatory concepts that contribute to historical consciousness and that refer specifically to historical events. Although analysis has identified colligatory concepts in historical discourse, these concepts have not yet been investigated empirically. We present a new methodology for studying these concepts and historical consciousness more broadly, as well as pilot data supporting the methodology. Our aim in the pilot study was to establish whether colligatory concepts are processed differently from control concepts when subjects are asked to judge historical statements. We compared judgments of colligatory concepts in healthy participants and in a patient group with impaired working memory cognitive processing capacity. Forty healthy, college-educated participants and 25 patients with Parkinson's disease were asked to rate narrative sentences containing historical content and an equal number of identically constructed narrative sentences of equal length but devoid of historical content. All participants rated their pre-test interest in history as relatively low (mean 5 out of 7). Though no group differences emerged, historical sentences were judged by both groups (total N = 65) to be significantly different from non-historical sentences across dimensions of interestingness, meaningfulness, likeability, complexity, thought provoking-ness, and truth content. Interestingly, historical sentences were judged to be truer than control sentences even though participants were not interested in and presumably knew little about history. The neurocognitive system appears to process sentences with historical content separately from sentences without historical content. The methodology described here appears to be a valid approach for study of processing of historical content of sentences. [ABSTRACT FROM PUBLISHER]