24 results on '"Gioele, Gioco"'
Search Results
2. Tongue Mucoceles: a retrospective clinic-pathological evaluation of 240 cases
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Romeo Patini, Michele Giuliani, Gioele Gioco, Mariateresa Tranfa, Vito Carlo Alberto Caponio, John Fantasia, and Carlo Lajolo
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Tongue ,Mucocele ,Retrospective study ,Dentistry ,RK1-715 - Abstract
Abstract Background Minor salivary glands can be found in the ventral and anterior part of the tongue; these glands can rarely develop mucoceles that, due to their rarity and their unusual clinical appearance, may present an interesting differential diagnosis. Mucoceles appear as an exophytic, sometimes pedunculated, lesion, which is a feature that is due to the absence of a capsule; thus, the glands are right beneath the mucosa and over the muscle tissue. The aim of this article is to retrospectively present and discuss the anatomy, pathology, clinical features and therapy of several cases of Blandin-Nunh mucoceles collected from two different institutions. Methods A retrospective case review was carried out in two university institutions, retrieving all cases of tongue mucoceles from 1999 to today. Two oral pathologists reviewed all the slides, confirming the diagnosis. Demographic data of the patient, anatomic location and clinical appearance were retrieved from clinical charts, together with the type of surgical procedure and possible relapses. Results A total of 240 cases of tongue mucoceles were gathered from the archives: the mean age was 22 years (DS = 14,7; Range 2–83), 126 were females (52,5%, mean age 22,7 years, DS = 16,5; Range 2–83), and 114 were males (47,5%, mean age 20,9 years, DS = 12,4; Range 3–73); in all cases, a history of trauma was reported. The ventral surface was the most frequent location (224 cases – 93,3%), and in the great majority (235 cases – 97,9%), pathology revealed mucous spillage with a wall formed by fibrous connective and granulation tissue with no epithelium lining the cavity. Superficial mucocele and sclerosing sialoadenitis were the more frequent pathological variants (21 cases – 8,8%). All lesions were treated with excision and enucleation of the servicing gland. The healing was uneventful in all cases, but there were four recurrences and two cases of sensory paraesthesia of the border of the tongue, all in males, except one case of paraesthesia in a female. Conclusions Tongue mucoceles must be differentiated from many benign and malignant lesions. For this reason, surgical removal of the lesion and of the associated gland with a pathological exam is mandatory. In fact, the anatomical location of the glands and the possible pathological variants must be considered to reach a correct diagnosis and diminish possible relapses. Trial registration CE-Muc_Ton_3/2023.
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- 2023
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3. Clinical outcomes of teeth adjacent to the site of mandibulotomy or mandibulectomy in patients with head and neck cancer: results from a multidisciplinary mono-institutional head and neck tumor board
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Raffaella Castagnola, Cosimo Rupe, Gioele Gioco, Giovanni Almadori, Jacopo Galli, Luca Tagliaferri, Alessandra Cassano, Patrizia Gallenzi, and Carlo Lajolo
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Head and Neck Cancer ,Oral Cancer ,Mandibulotomy ,Mandibulectomy ,Tooth prognosis ,Tooth survival ,Dentistry ,RK1-715 - Abstract
Abstract Introduction The aim of this case series was to evaluate the necrosis of teeth adjacent to the site of mandibulotomy or mandibulectomy in a cohort of patients suffering from head and neck cancers. Methods Fourteen patients who underwent segmental mandibulectomy or paramedian mandibulotomy for oral, oropharynx or major salivary gland cancer and a total of 23 teeth were included in this case series. Twelve patients underwent adjuvant head and neck radiotherapy. Cold sensitivity pulp testing and/or electric pulp testing were performed on teeth at the margin of mandibulectomy and on teeth adjacent to mandibulotomy after surgery. A “positive” response was considered the healthy state, and “negative” was considered the diseased state of the tooth. Results The 10 patients who underwent mandibulotomy had 12 teeth with a negative response. The 4 patients treated by mandibulectomy had two positive and three negative responses to cold and electric pulp tests. Fifteen out of 23 teeth (65.2%) showed a negative response to sensitivity testing. Conclusions Tooth necrosis seems to be a common event after mandibulectomy and mandibulotomy. Clinical Relevance To avoid post-surgery complications, performing root canal therapy before surgery on the teeth adjacent to the surgical site could be an appropriate strategy.
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- 2023
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4. Malnutrition as a Risk Factor in the Development of Oral Cancer: A Systematic Literature Review and Meta-Analyses
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Romeo Patini, Eleonora Favetti Giaquinto, Gioele Gioco, Raffaella Castagnola, Vittoria Perrotti, Cosimo Rupe, Leonardo Di Gennaro, Giuseppina Nocca, and Carlo Lajolo
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hypovitaminosis ,malnutrition ,oral cancer ,vitamins ,Nutrition. Foods and food supply ,TX341-641 - Abstract
This systematic review and meta-analyses aimed to assess whether malnutrition may increase the incidence of oral cancer. Following the PRISMA statement, the research was conducted on PubMed, Scopus, and MEDLINE via OVID without any time restrictions. The risk of bias was assessed, and the quality of evidence for each performed meta-analysis was evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework. Sixty-one articles met the inclusion criteria and seven studies underwent quantitative evaluation. For our meta-analysis on hypovitaminosis B, three studies with a total of 90,011 patients were included. An odds ratio of 2.22 was found. Our meta-analysis on the correlation between vitamin C and oral cancer included one study with a total of 866 patients and the derived odds ratio was 1.06. Our meta-analysis on the relationship between vitamin D deficiency and the incidence of oral cancer included three studies with a total of 12,087 patients and the odds ratio was −2.58. The GRADE system showed a moderate strength of evidence due to the presence of studies with a high risk of bias and high indirectness of the data given. The present findings suggest that an inadequate intake of vitamins, particularly vitamin D, poses a risk for the onset of oral cancer.
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- 2024
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5. Sodium-hyaluronate Mouthwash on Radiotherapy-induced Xerostomia: a Randomized Clinical Trial
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Cosimo Rupe, Alessia Basco, Gioele Gioco, Romeo Patini, Alberta Lucchese, Francesco Micciché, Mariangela Massaccesi, and Carlo Lajolo
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Introduction: Radiotherapy-Induced Xerostomia (RIX) is one of the most common adverse effects of Radiotherapy (RT) in the Head and Neck Cancer patients (HNC), and a major determinant of survivors' quality of life. The primary objective was to evaluate the reduction of patients’ xerostomia symptoms after the utilization of a sodium-hyaluronate mouthwash compared to a placebo solution. The secondary objectives were to evaluate the improvement of quality of life, and to evaluate the patients’ satisfaction. Methods: The protocol was approved by the ethical committee (Ref. 50053/19) and registered at ClinicalTrials.gov (ID: NCT05103124). The study was a double-blind randomized clinical trial (RCT) with a crossover design and was conducted the Fondazione Policlinico Universitario A. Gemelli, Rome Results: Thirty-two patients completed the study protocol. Lower values of the modified Xerostomia Questionnaire (XQ) were retrieved when comparing the baseline scores to the ones after treatment, when compared with placebo (Mann-Whitney U test = 0.01); higher values of patients’ satisfaction (Likert Scale) and modified XQ were retrieved for the sodium-hyaluronate mouthwash (Mann-Whitney U test = 0.001). Conclusions: This RCT highlight the advantages of treating RIX with the sodium-hyaluronate mouthwash, since it seems to be clinically effective in reducing its symptoms, without any reported adverse events.
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- 2023
6. Overview on Osteoporosis, Periodontitis and Oral Dysbiosis: The Emerging Role of Oral Microbiota
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Maria Contaldo, Annalisa Itro, Carlo Lajolo, Gioele Gioco, Francesco Inchingolo, and Rosario Serpico
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osteoporosis ,periodontitis ,oral health ,bone and bones/metabolism ,microbiome ,microbiota ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Osteoporosis (OP) is a bone disease consisting of a progressive loss of bone mineral density (BMD) and therefore resulting in greater susceptibility to fractures. OP shares a number of risk factors and demographic characteristics with periodontitis (PD), a bacteria-induced chronic inflammation of periodontal structures that leads to loss of alveolar bone and teeth. In the last decade, with the advent of gut and oral microbiome studies and profiling, a growing diagnostic and prognostic significance has been attributed to dysbiosis associated with various systemic and organ-specific pathologies. This evidence has inspired research on modulating the microbiota to restore health by the use of prebiotics and probiotics. The aim of this work is to overview the bidirectional interrelationships between OP and PD, reporting the most recent evidence on triggering factors and, mainly, the role of gut and oral dysbiosis in the onset and progression of both OP and PD, with the perspective in their therapy.
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- 2020
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7. Oral
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Cosimo, Rupe, Gioele, Gioco, Giovanni, Almadori, Jacopo, Galli, Francesco, Micciché, Michela, Olivieri, Massimo, Cordaro, and Carlo, Lajolo
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This study aims to find a correlation betweenThe protocol was registered on ClinicalTrials.gov (ID: NCT04009161) and approved by the ethical committee of the 'Fondazione Policlinico Universitario Gemelli IRCCS' (22858/18). An oral swab was obtained before RT to assess the presence ofNo patient developed G4 OM, and only 36/152 patients (23.7%) developed G3 OM. Tumour site and lymphocytopenia were risk factors for severe OM (OR for tumour site: 1.29, 95% CI: 1-1.67
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- 2022
8. Oral Candida spp. Colonisation Is a Risk Factor for Severe Oral Mucositis in Patients Undergoing Radiotherapy for Head & Neck Cancer: Results from a Multidisciplinary Mono-Institutional Prospective Observational Study
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Rupe, Cosimo, Gioco, Gioele, Almadori, Giovanni, Galli, Jacopo, Micciché, Francesco, Olivieri, Michela, Cordaro, Massimo, Lajolo, Carlo, Gioele Gioco (ORCID:0000-0002-8637-2029), Giovanni Almadori (ORCID:0000-0002-4605-2442), Jacopo Galli (ORCID:0000-0001-6353-6249), Massimo Cordaro (ORCID:0000-0002-0797-5172), Carlo Lajolo (ORCID:0000-0003-4663-9734), Rupe, Cosimo, Gioco, Gioele, Almadori, Giovanni, Galli, Jacopo, Micciché, Francesco, Olivieri, Michela, Cordaro, Massimo, Lajolo, Carlo, Gioele Gioco (ORCID:0000-0002-8637-2029), Giovanni Almadori (ORCID:0000-0002-4605-2442), Jacopo Galli (ORCID:0000-0001-6353-6249), Massimo Cordaro (ORCID:0000-0002-0797-5172), and Carlo Lajolo (ORCID:0000-0003-4663-9734)
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Simple Summary This study aims to find a correlation between Candida spp. oral colonisation prior to radiotherapy and (i) the development of severe oral mucositis (OM) (grade 3/4) and (ii) early development of severe OM (EOM). Candida spp. in the oral cavity appears to be a predictive factor of EOM. Preventive treatment could aid in reducing incidence of EOM. Further clinical trials are required to confirm our findings. Background: This study aims to find a correlation between Candida spp. oral colonisation prior to radiotherapy (RT) and (i) the development of severe oral mucositis (OM) (grade 3/4) and (ii) early development of severe OM (EOM). Methods: The protocol was registered on ClinicalTrials.gov (ID: NCT04009161) and approved by the ethical committee of the 'Fondazione Policlinico Universitario Gemelli IRCCS' (22858/18). An oral swab was obtained before RT to assess the presence of Candida spp. Severe OM occurring before a dose of 40 Gy was defined as EOM. Results: No patient developed G4 OM, and only 36/152 patients (23.7%) developed G3 OM. Tumour site and lymphocytopenia were risk factors for severe OM (OR for tumour site: 1.29, 95% CI: 1-1.67, p = 0.05; OR for lymphocytopenia: 8.2, 95% CI: 1.2-55.8, p = 0.03). We found a correlation between Candida spp. and EOM (OR: 5.13; 95% CI: 1.23-21.4 p = 0.04). Patients with oral colonisation of Candida spp. developed severe OM at a mean dose of 38.3 Gy (range: 28-58; SD: 7.6), while negative patients did so at a mean dose of 45.6 Gy (range: 30-66; SD: 11.1). Conclusions: Candida spp. in the oral cavity appears to be a predictive factor of EOM.
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- 2022
9. Tooth extraction before radiotherapy is a risk factor for developing osteoradionecrosis of the jaws: A systematic review
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Gioele Gioco, Cosimo Rupe, Massimo Cordaro, Giuseppe Troiano, Carlo Lajolo, Gaetano Paludetti, M. Giuliani, Alberta Lucchese, Lajolo, C., Gioco, G., Rupe, C., Troiano, G., Cordaro, M., Lucchese, A., Paludetti, G., and Giuliani, M.
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Web of science ,Osteoradionecrosis ,medicine.medical_treatment ,Dentistry ,Settore MED/28 - MALATTIE ODONTOSTOMATOLOGICHE ,03 medical and health sciences ,jaw ,0302 clinical medicine ,Risk Factors ,osteoradionecrosis ,medicine ,Humans ,In patient ,Risk factor ,General Dentistry ,radiotherapy ,Retrospective Studies ,tooth extraction ,business.industry ,osteoradionecrosi ,Incidence (epidemiology) ,Head and neck cancer ,030206 dentistry ,medicine.disease ,Radiation therapy ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,head and neck cancer ,business ,Clinical risk factor - Abstract
Objectives: The aim of this systematic review was to estimate the osteoradionecrosis rate in patients with head and neck cancer due to teeth extraction performed before radiotherapy and to identify possible risk factors. Material and Methods: PRISMA protocol was used to evaluate and present the results. PubMed, Scopus and Web of Science were used as search engines: English full-length papers of clinical studies, in peer-reviewed journals, were investigated. Cumulative meta-analysis was performed with a random effects model (PROSPERO registration code: CRD42018079986). Results: Among 2,020 records screened, 8 were included in this review. Sixteen of 494 patients who underwent tooth extraction before radiotherapy developed osteoradionecrosis, with an osteoradionecrosis incidence of 2.2% (95% Confidence of Interval=0.6–3.9, p 
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- 2020
10. Oral juvenile xanthogranuloma: An unusual presentation in an adult patient and a systematic analysis of published cases
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Gioele Gioco, Cosimo Rupe, Maria Contaldo, Patrizia Gallenzi, Carlo Lajolo, Alessia Basco, Gioco, G., Rupe, C., Basco, A., Contaldo, M., Gallenzi, P., and Lajolo, C.
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Adult ,medicine.medical_specialty ,Web of science ,Juvenile xanthogranuloma ,Juvenile ,Pathology and Forensic Medicine ,Settore MED/28 - MALATTIE ODONTOSTOMATOLOGICHE ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Unusual case ,Xanthogranuloma ,business.industry ,medicine.disease ,Dermatology ,Histiocytosis ,Systematic review ,Surgery ,Female ,Oral Surgery ,Presentation (obstetrics) ,Mouth Diseases ,business ,Mouth Disease ,Xanthogranuloma, Juvenile ,Human - Abstract
Objective The purpose of this study was to describe an unusual case of intraoral juvenile xanthogranuloma (JXG) and to perform a systematic review to investigate the available literature regarding oral JXGs. Study design We present a new case of oral JXG arising in a 36-year-old Italian woman and conducted a systematic literature review in PubMed, Web of Science and Scopus, according to the PRISMA guidelines. Results Our review of the English-language literature yielded 34 cases of oral JXG, which are included in our case report. Conclusions JXG is a non-Langerhans cell histiocytosis. Oral JXG has been reported, but it is a rare manifestation. Because of the rarity of oral lesions and possible variations in the clinical and histological presentation, the correct diagnosis can be challenging, requiring a careful clinical and histopathological evaluation with adjuvant immunohistochemical studies.
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- 2022
11. Oral Candida spp. Colonisation Is a Risk Factor for Severe Oral Mucositis in Patients Undergoing Radiotherapy for Head & Neck Cancer: Results from a Multidisciplinary Mono-Institutional Prospective Observational Study
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Cosimo Rupe, Gioele Gioco, Giovanni Almadori, Jacopo Galli, Francesco Micciché, Michela Olivieri, Massimo Cordaro, and Carlo Lajolo
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Settore MED/28 - MALATTIE ODONTOSTOMATOLOGICHE ,Cancer Research ,Oncology ,oral mucositis ,radiotherapy ,head and neck cancer ,oral Candida spp ,oral candidiasis ,chemotherapy ,radiochemotherapy - Abstract
Background: This study aims to find a correlation between Candida spp. oral colonisation prior to radiotherapy (RT) and (i) the development of severe oral mucositis (OM) (grade 3/4) and (ii) early development of severe OM (EOM). Methods: The protocol was registered on ClinicalTrials.gov (ID: NCT04009161) and approved by the ethical committee of the ‘Fondazione Policlinico Universitario Gemelli IRCCS’ (22858/18). An oral swab was obtained before RT to assess the presence of Candida spp. Severe OM occurring before a dose of 40 Gy was defined as EOM. Results: No patient developed G4 OM, and only 36/152 patients (23.7%) developed G3 OM. Tumour site and lymphocytopenia were risk factors for severe OM (OR for tumour site: 1.29, 95% CI: 1–1.67, p = 0.05; OR for lymphocytopenia: 8.2, 95% CI: 1.2–55.8, p = 0.03). We found a correlation between Candida spp. and EOM (OR: 5.13; 95% CI: 1.23–21.4 p = 0.04). Patients with oral colonisation of Candida spp. developed severe OM at a mean dose of 38.3 Gy (range: 28–58; SD: 7.6), while negative patients did so at a mean dose of 45.6 Gy (range: 30–66; SD: 11.1). Conclusions: Candida spp. in the oral cavity appears to be a predictive factor of EOM.
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- 2022
12. Oral Candida and psoriasis: Is there association? A systematic review and trial sequential analysis
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Romeo Patini, Gioele Gioco, Cosimo Rupe, Maria Contaldo, Rosario Serpico, Michele Giuliani, Carlo Lajolo, Patini, R, Gioco, G, Rupe, C, Contaldo, M, Serpico, R, Giuliani, M, and Lajolo, C
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Settore MED/28 - MALATTIE ODONTOSTOMATOLOGICHE ,Otorhinolaryngology ,oral Candida ,oral candidiasis ,psoriasis ,General Dentistry ,oral candidiasi - Abstract
To assess (i) the prevalence of oral colonization by Candida spp. in patients with psoriasis and (ii) the prevalence of oral lesions associated with Candida spp. in patients with psoriasis and identify the risk factors for oral lesions. A systematic review was conducted in accordance with PRISMA criteria. The PROSPERO registration code is CRD42019127178. PubMed, Scopus and Web of Science were used as search engines. Meta-analyses and trial sequential analyses were performed. Among the 5805 retrieved records, nine articles were included. Among 530 psoriatic patients, 255 patients had an oral Candida spp. colonisation with an odds ratio (OR) = 3.44 (95% CI:2.38-5.00). Among 490 psoriatic patients, 43 patients developed oral Candida spp. lesions with an OR = 5.31 (95% CI:1.04-27.23). Among the patients without the main predisposing factors for infections, psoriatic patients had a higher OR (3.48, 95% CI: 2.0-6.0) for Candida spp. colonization, but not for Candida spp. infection, when compared with healthy controls (p-value > 0.05). Meta-analysis showed a higher risk of Candida spp. colonisation in patients with psoriasis. Patients who received immunosuppressive therapies were also at higher risk of developing oral lesions. Further studies are needed to understand these associations.
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- 2022
13. Psoriasi Orale e Disordini Temporo-mandibolari: una revisione sistematica con meta-analisi
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A. Di Petrillo, Gioele Gioco, Cosimo Rupe, G. Isola, Carlo Lajolo, Romeo Patini, and A. Di Giovanni
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- 2021
14. Saprochaete clavata Infection in Immunosuppressed Patients: Systematic Review of Cases and Report of the First Oral Manifestation, Focusing on Differential Diagnosis
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Simona Sica, Maria Contaldo, Cosimo Rupe, Carlo Lajolo, Gioele Gioco, Anna Schiavelli, Elisabetta Metafuni, Lajolo, C., Cosimo, R., Anna, S., Gioele, G., Elisabetta, M., Contaldo, M., and Sica, S.
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Male ,Pediatrics ,medicine.medical_specialty ,Health, Toxicology and Mutagenesis ,Fulminant ,Saprochaete clavata ,MEDLINE ,lcsh:Medicine ,Review ,rare mycoses ,Saccharomycetale ,Settore MED/28 - MALATTIE ODONTOSTOMATOLOGICHE ,Diagnosis, Differential ,03 medical and health sciences ,Immunocompromised Host ,0302 clinical medicine ,Diagnosis ,Medicine ,Humans ,Geotrichum clavatum ,0303 health sciences ,030306 microbiology ,business.industry ,Mortality rate ,Rare mycose ,fungi ,lcsh:R ,Public Health, Environmental and Occupational Health ,Myeloid leukemia ,Mean age ,Middle Aged ,Systematic review ,030220 oncology & carcinogenesis ,Saccharomycetales ,Differential ,Female ,Differential diagnosis ,business ,Fungemia ,Invasive Fungal Infections ,Human - Abstract
Background: Saprochaete clavata infection is an emerging issue in immunosuppressed patients, causing fulminant fungaemia. The purpose of this systematic review of cases is to retrieve all cases of S. clavata infection and describe oral lesions as the first manifestation of S. clavata infection. Methods: We report the first case of intraoral S. clavata infection in Acute Myeloid Leukemia (AML) affected subject, presenting as multiple grayish rapidly growing ulcerated swellings, and provide a review of all published cases of infection caused by S. clavata, according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, conducted by searching SCOPUS, Medline, and CENTRAL databases. Only articles in English were considered. Individual patient data were analyzed to identify risk factors for S. clavata infection. Results: Seventeen of 68 retrieved articles were included in the review reporting data on 96 patients (mean age 51.8 years, 57 males and 38 females). Most cases were disseminated (86) with a 60.2% mortality rate. Ninety-five were hematological patients, with AML being the most common (57 cases). Conclusions:S. clavata infection in immunosuppressed patients has a poor prognosis: middle-age patients, male gender and Acute Myeloid Leukemia should be considered risk factors. In immunosuppressed patients, the clinical presentation can be particularly unusual, imposing difficult differential diagnosis, as in the reported case.
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- 2021
15. Psychological profile and unexpected pain in oral lichen planus: a case-control multicenter SIPMO study
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Gianluca Tenore, Andrea Sardella, Daniela Adamo, Lucio Montebugnoli, Alessandro Antonelli, Lorenzo Azzi, Elena Calabria, Vera Panzarella, Rosario Serpico, Michele D. Mignogna, Alessio Gambino, Marco Nisi, Davide Bartolomeo Gissi, Giuseppina Campisi, Fabio Croveri, Marco Ardore, Massimo Aria, Margherita Gobbo, Luca Guarda Nardini, Marco Cabras, Paolo Vescovi, Giuseppe Colella, Elena Bardellini, Sonia Marino, Monica Pentenero, Mario Gabriele, M. Giuliani, Ciro Emiliano Boschetti, Lorenzo Lo Muzio, Elena Maria Varoni, Carlo Lajolo, Matteo Biasotto, Spadari Francesco, Giovanni Lodi, Sipmo, Gioele Gioco, Maria Eleonora Bizzoca, Umberto Romeo, Alessandra Majorana, Amerigo Giudice, Noemi Coppola, Adamo, Daniela, Calabria, Elena, Coppola, Noemi, Lo Muzio, Lorenzo, Giuliani, Michele, Bizzoca, Maria Eleonora, Azzi, Lorenzo, Croveri, Fabio, Colella, Giuseppe, Boschetti, Ciro Emiliano, Montebugnoli, Lucio, Gissi, Davide, Gabriele, Mario, Nisi, Marco, Sardella, Andrea, Lodi, Giovanni, Varoni, Elena M, Giudice, Amerigo, Antonelli, Alessandro, Cabras, Marco, Gambino, Alessio, Vescovi, Paolo, Majorana, Alessandra, Bardellini, Elena, Campisi, Giuseppina, Panzarella, Vera, Spadari, Francesco, Marino, Sonia, Pentenero, Monica, Ardore, Marco, Biasotto, Matteo, Gobbo, Margherita, Guarda Nardini, Luca, Romeo, Umberto, Tenore, Gianluca, Serpico, Rosario, Lajolo, Carlo, Gioco, Gioele, Aria, Massimo, Mignogna, Michele Davide, Adamo D., Calabria E., Coppola N., Lo Muzio L., Giuliani M., Bizzoca M.E., Azzi L., Croveri F., Colella G., Boschetti C.E., Montebugnoli L., Gissi D., Gabriele M., Nisi M., Sardella A., Lodi G., Varoni E.M., Giudice A., Antonelli A., Cabras M., Gambino A., Vescovi P., Majorana A., Bardellini E., Campisi G., Panzarella V., Francesco S., Marino S., Pentenero M., Ardore M., Biasotto M., Gobbo M., Guarda Nardini L., Romeo U., Tenore G., Serpico R., Lajolo C., Gioco G., Aria M., and Mignogna M.D.
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medicine.medical_specialty ,oral lichen planu ,Pittsburgh Sleep Quality Index ,Settore MED/28 - MALATTIE ODONTOSTOMATOLOGICHE ,03 medical and health sciences ,0302 clinical medicine ,oral lichen planus ,stomatognathic system ,mental disorders ,medicine ,anxiety ,depression ,pain ,sleep disturbance ,General Dentistry ,Sleep disorder ,business.industry ,Epworth Sleepiness Scale ,Rating scales for depression ,030206 dentistry ,medicine.disease ,Dermatology ,humanities ,stomatognathic diseases ,Peripheral neuropathy ,Otorhinolaryngology ,Mood disorders ,030220 oncology & carcinogenesis ,Anxiety ,Oral lichen planus ,medicine.symptom ,business - Abstract
Objectives: To analyze psychological profiles, pain and oral symptoms in patients with oral lichen planus (OLP). Materials and methods: 300 patients with keratotic OLP (K-OLP; reticular, papular, plaque-like subtypes), 300 patients with predominant non-keratotic OLP (nK-OLP; erythematosus atrophic, erosive, ulcerative, bullous subtypes) and 300 controls were recruited in 15 universities. The number of oral sites involved and oral symptoms were recorded. The Numeric Rating Scale (NRS), Total Pain Rating Index (T-PRI), Hamilton Rating Scales for Depression and for Anxiety (HAM-D and HAM-A), Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS) were administered. Results: The OLP patients, especially the nK-OLP, showed higher scores in the NRS, T-PRI, HAM-D, HAM-A and PSQI compared with the controls (p-value
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- 2021
16. Patient perception after oral biopsies: an observational outpatient study
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Maria Contaldo, I. Rizzo, Gioele Gioco, Cosimo Rupe, Umberto Romeo, Carlo Lajolo, Massimo Cordaro, Romeo Patini, Lajolo, C., Gioco, G., Rupe, C., Patini, R., Rizzo, I., Romeo, U., Contaldo, M., and Cordaro, M.
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medicine.medical_specialty ,OHIP-14 ,Biopsy ,Oral health related quality of life ,Oral Health ,Patient’s perception ,Lesion ,Settore MED/28 - MALATTIE ODONTOSTOMATOLOGICHE ,03 medical and health sciences ,0302 clinical medicine ,Surveys and Questionnaires ,Internal medicine ,Outpatients ,Numeric Rating Scale ,Surveys and Questionnaire ,Humans ,Medicine ,In patient ,Correlation test ,General Dentistry ,medicine.diagnostic_test ,business.industry ,Mouth Mucosa ,030206 dentistry ,oral biopsy ,oral health related quality of life ,patient’s perception ,humanities ,Patient perceptions ,030220 oncology & carcinogenesis ,Quality of Life ,Perception ,Observational study ,medicine.symptom ,business ,Statistical correlation ,Human ,Oral biopsy - Abstract
Objective: The aim of this study was to evaluate the postoperative course in patients undergoing oral mucosal biopsies, considering clinical and patient’s perception variables potentially correlated to poor healing. Subjects and methods: Eighty patients underwent oral biopsies. All the variables connected with the surgery were recorded, and the harvested volume was calculated through image software (ImageJ, NIH, Betesda, USA). To evaluate the postoperative discomfort, the OHIP-14 and the numeric rating scale of pain (NRS) were administered at 6 h, 7 days and 21 days after biopsy. Results: Six hours after the biopsy, 22 (OHIP-14 ≥ 20) and 24 (NRS ≥ 4) patients experienced a troublesome or painful healing, respectively. A significant statistical correlation between poor healing and high scores of NRS and OHIP was detected (Pearson’s correlation test p < 0.05). Higher values of OHIP-14 were correlated to the type of lesion (OR = 1.165; p < 0.05), whereas high values of NRS were correlated to the use of systemic drugs (p < 0.05). No surgical variable had a significant statistical correlation with any of the outcomes. Conclusions: The clinical evaluation was correlated with the patient’s perception of pain and discomfort. This finding could be suggestive of the fact that wound healing can be reliably monitored with the help of these tools. Clinical relevance: Patient perception can be a predictor of the healing of biopsied tissues.
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- 2021
17. Teeth Extractions in Subjects Undergoing Radiotherapy for Head and Neck Cancers: A Systematic Review on the Clinical Protocols for Preventing Osteoradionecrosis (ORN). Extractions after Radiotherapy (Part 2)
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Gioele Gioco, Cosimo Rupe, Giuseppe Troiano, Michele Giuliani, Massimo Petruzzi, and Carlo Lajolo
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- 2019
18. Oral Manifestations of Psoriasis: A Systematic Review
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Patrizia Gallenzi, Gioele Gioco, Giuseppe Troiano, Carlo Lajolo, Luisa Limongelli, Alessia Di Petrillo, and Romeo Patini
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medicine.medical_specialty ,business.industry ,Psoriasis ,medicine ,medicine.disease ,business ,Dermatology - Published
- 2019
19. Teeth Extractions in Subjects Undergoing Radiotherapy for Head and Neck Cancers: A Systematic Review on the Clinical Protocols for Preventing Osteoradionecrosis (ORN). Extractions before Radiotherapy (Part 1)
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Maria Contaldo, Gioele Gioco, Cosimo Rupe, Giuseppe Troiano, Michele Giuliani, and Carlo Lajolo
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Radiation therapy ,medicine.medical_specialty ,Side effect ,business.industry ,Osteoradionecrosis ,medicine.medical_treatment ,medicine ,Head and neck ,business ,medicine.disease ,Surgery - Abstract
Osteoradionecrosis (ORN) of the jaws is the most severe side effect, in some case life-threatening, [...]
- Published
- 2019
20. Rate of malignant transformation of oral lichen planus: A systematic review
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M. Giuliani, Massimo Cordaro, Gioele Gioco, Giuseppe Troiano, Carlo Lajolo, Lorenzo Lo Muzio, Pamela Pignatelli, and Massimo Corsalini
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Potentially Malignant Disorders ,medicine.medical_specialty ,Oral Medicine ,English language ,Malignant transformation ,Settore MED/28 - MALATTIE ODONTOSTOMATOLOGICHE ,03 medical and health sciences ,Sex Factors ,0302 clinical medicine ,Tongue ,stomatognathic system ,Malignant Transformation ,Oral and maxillofacial pathology ,Humans ,Medicine ,Oral Lichenoid Lesions ,General Dentistry ,Lichenoid lesions ,business.industry ,Oral Cancer ,Oral Lichen Planus ,Oral Pathology ,030206 dentistry ,medicine.disease ,Dermatology ,stomatognathic diseases ,Cell Transformation, Neoplastic ,medicine.anatomical_structure ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Carcinoma, Squamous Cell ,Mouth Neoplasms ,Observational study ,Oral lichen planus ,business ,Oral medicine ,Lichen Planus, Oral - Abstract
Objective The aim of this study was to systematically review the literature to determine: (a) the malignant transformation rate (TR) of oral lichen planus (OLP) and its risk factors; (b) whether or not oral lichenoid lesions (OLL) have a different malignant TR. Materials and methods PubMed, Scopus, and Web of Science were used as search engines: only observational, full-length, English language studies were investigated. PRISMA protocol was used to evaluate and present results. PROSPERO registration code is CRD42016048529. Results Among 7,429 records screened, only 21 were included in this review. Ninety-two of 6,559 patients developed oral squamous cell carcinoma, with an overall TR of 1.40% (1.37% for OLP and 2.43% for OLL), an annual TR of 0.20%. Female gender, red clinical forms, and tongue site seem to slightly increase the transformation risk. Conclusions This systematic review confirms that both OLP and OLL, the latter with a slightly higher TR, may be considered potentially malignant disorders and suggest that erosive type, female gender and tongue site should be considered as risk factors for OLP transformation. Major efforts should be done to establish strict clinical and histological criteria to diagnose OLP and to perform sounder methodological observational studies.
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- 2018
21. Osteoradionecrosis of the Jaws Due to Teeth Extractions during and after Radiotherapy: A Systematic Review
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Francesco Miccichè, Cosimo Rupe, Giuseppe Troiano, Carlo Lajolo, M. Giuliani, Gioele Gioco, Massimo Petruzzi, and Romeo Patini
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Cancer Research ,Osteoradionecrosis ,medicine.medical_treatment ,Dentistry ,Settore MED/28 - MALATTIE ODONTOSTOMATOLOGICHE ,jaw ,osteoradionecrosis ,medicine ,Risk factor ,Head and neck ,RC254-282 ,radiotherapy ,tooth extraction ,business.industry ,Head and neck cancer ,Mandible ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,respiratory system ,medicine.disease ,Radiation therapy ,Oncology ,Maxilla ,head and neck cancer ,sense organs ,Systematic Review ,business ,Clinical risk factor - Abstract
Simple Summary Teeth extractions before or after radiotherapy (RT) could be procedures at high risk for osteoradionecrosis (ORN) onset. This systematic review was performed to investigate the ORN incidence following teeth extractions during and after RT for head and neck (H&N) cancer and to evaluate any other possible risk factor. The results highlight how post-RT teeth extractions are a major risk factor for ORN onset (ORN incidence of 5.8%), especially in the mandible, with a diminishing trend in the last years. Abstract Teeth extractions before or after radiotherapy (RT) could be procedures at high risk for osteoradionecrosis (ORN) onset. This systematic review was performed to investigate the ORN incidence following teeth extractions during and after RT for head and neck (H&N) cancer and to evaluate any other possible risk factor. Methods: This systematic review was conducted according to PRISMA protocol, and the PROSPERO registration number was CRD42018079986. An electronic search was performed on the following search engines: PubMed, Scopus, and Web of Science. A cumulative meta-analysis was performed. Results: Two thousand two hundred and eighty-one records were screened, and nine were finally included. This systematic review revealed an ORN incidence of 5.8% (41 patients out of 462, 95% CI = 2.3–9.4); 3 ORN developed in the maxilla. No other clinical risk factors were detected. Conclusion: Post-RT teeth extractions represent a major risk factor for ORN development, especially in the mandible, with a diminishing trend in the last years. Further research on other possible risk factors might improve this evidence.
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- 2021
22. Oral health of patients undergoing radiotherapy for head and neck cancer treatment: a Preliminary Report of a Prospective Observational clinical study
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Massimo Cordaro, Gaetano Paludetti, Gioele Gioco, Francesco Miccichè, Cosimo Rupe, and Carlo Lajolo
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medicine.medical_specialty ,Physiology ,business.industry ,medicine.medical_treatment ,Head and neck cancer ,Oral health ,medicine.disease ,Clinical study ,Radiation therapy ,Preliminary report ,Physiology (medical) ,medicine ,Observational study ,Radiology ,business - Published
- 2019
23. Intraoral juvenile xanthogranuloma: an unusual presentation in an adult subject and literature review
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Gioele Gioco, Carlo Lajolo, Massimo Petruzzi, Gianluigi Petrone, Alberta Lucchese, and Maria Contaldo
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medicine.medical_specialty ,business.industry ,Juvenile xanthogranuloma ,Physiology ,Physiology (medical) ,medicine ,Subject (documents) ,Presentation (obstetrics) ,business ,medicine.disease ,Dermatology - Published
- 2019
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24. The association between periodontitis and sleep duration
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Giorgio Deli, Andreina Laforí, Giorgio Perfetti, Mario Romandini, Edoardo Staderini, and Gioele Gioco
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Adult ,Male ,medicine.medical_specialty ,Time Factors ,Dentistry ,Systemic inflammation ,Logistic regression ,Settore MED/28 - MALATTIE ODONTOSTOMATOLOGICHE ,Korea National Health And Nutrition Examination Survey (KNHANES) ,association ,epidemiology ,inflammation ,oxidative stress ,periodontal diseases ,periodontitis ,risk factors ,sleep ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Diabetes mellitus ,Internal medicine ,Epidemiology ,Republic of Korea ,medicine ,Prevalence ,Humans ,Risk factor ,Periodontitis ,Aged ,medicine.diagnostic_test ,business.industry ,Confounding Factors, Epidemiologic ,030206 dentistry ,Odds ratio ,Middle Aged ,medicine.disease ,Health Surveys ,Cross-Sectional Studies ,Logistic Models ,Case-Control Studies ,Periodontics ,Female ,medicine.symptom ,Lipid profile ,business ,Sleep ,030217 neurology & neurosurgery - Abstract
Aim Due to its potential to influence systemic inflammation and oxidative stress, and to predispose to bacterial infections, sleep duration could potentially be a risk factor for periodontitis. The aim of this cross-sectional study was to evaluate if there was in 2012 an association between periodontitis and sleep duration in a representative sample of the South Korean population. Materials and Methods A total of 5812 subjects representative of 39.4 million of adults were examined. Multivariate logistic regressions were applied controlling for age, gender, education, smoking status, alcoholism and consumption frequency of coffee, tea, chocolate and red wine. Results Compared to the group sleeping ≤5 h/day, the adjusted odds ratios for periodontitis prevalence defined as Community Periodontal Index (CPI) = 4 were OR = 2.46 (95% CI: 1.20–5.06) in the 6 h/day sleepers group, OR = 2.66 (95% CI: 1.35–5.25) in the 7 h/day sleepers group, OR = 2.29 (95% CI: 1.13–4.63) in the 8 h/day sleepers group and OR = 4.27 (95% CI: 1.83–9.97) in the ≥9 h/day sleepers group. The association has shown to be highlighted in middle-aged people, females, non-smokers, lower educated, with lower lead and higher cadmium blood levels and with higher carotene dietary intake ones and to be partially mediated by lipid profile alterations, diabetes, serum Vitamin D levels and WBC count. Conclusions A novel, direct and independent association between sleep duration and the prevalence of periodontitis was found. However, it needs to be investigated how the factors influencing the sleep duration affect this association.
- Published
- 2017
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