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13. Body Mass Index Adversely Affects Survival in Left Ventricular Assist Device Bridged Patients Undergoing Heart Transplantation

Author

Deo, S., primary, Kumar, S., additional, Altarabsheh, S., additional, Kerner, J., additional, Benavides, J., additional, Sareyyupoglu, B., additional, Medalion, B., additional, Elgudin, Y., additional, Elamm, C., additional, Ginwalla, M., additional, Benatti, R., additional, Zacharias, M., additional, Oliveira, G.H., additional, Fonarow, G.C., additional, and Park, S.J., additional

Published
2016
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17. Impact of Early Adoption of Affordable Care Act Medicaid Expansion on Heart Transplant Listings in the United States

Author

Al-Kindi, S.G., primary, Farhoud, M., additional, Sabeh, M., additional, Ginwalla, M., additional, ElAmm, C., additional, Zacharias, M., additional, Benatti, R.D., additional, Kattea, M., additional, Deo, S., additional, Sareyyupoglu, B., additional, Medalion, B., additional, Park, S., additional, and Oliveira, G.H., additional

Published
2016
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45. (555) - Body Mass Index Adversely Affects Survival in Left Ventricular Assist Device Bridged Patients Undergoing Heart Transplantation.

Author

Deo, S., Kumar, S., Altarabsheh, S., Kerner, J., Benavides, J., Sareyyupoglu, B., Medalion, B., Elgudin, Y., Elamm, C., Ginwalla, M., Benatti, R., Zacharias, M., Oliveira, G.H., Fonarow, G.C., and Park, S.J.

Subjects
*LEFT heart ventricle diseases, *HEART assist devices, *HEART transplantation, *BODY mass index, *MEDICAL publishing, *MEDICAL research
Published
2016
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49. Membrane bending and sphingomyelinase-associated, sulfatide-dependent hypoxic adhesion of sickle mature erythrocytes.

Author

Goreke U, Kucukal E, Wang F, An R, Arnold N, Quinn E, Yuan C, Bode A, Hill A, Man Y, Hambley BC, Schilz R, Ginwalla M, Little JA, and Gurkan UA

Subjects
Humans, Sphingomyelin Phosphodiesterase metabolism, Erythrocytes metabolism, Erythrocyte Membrane metabolism, Hypoxia metabolism, Hemoglobin, Sickle metabolism, Anemia, Sickle Cell
Abstract

Abnormal erythrocyte adhesion owing to polymerization of sickle hemoglobin is central to the pathophysiology of sickle cell disease (SCD). Mature erythrocytes constitute >80% of all erythrocytes in SCD; however, the relative contributions of erythrocytes to acute and chronic vasculopathy in SCD are not well understood. Here, we showed that bending stress exerted on the erythrocyte plasma membrane by polymerization of sickle hemoglobin under hypoxia, enhances sulfatide-mediated abnormal mature erythrocyte adhesion. We hypothesized that sphingomyelinase (SMase) activity, which is upregulated by accumulated bending energy, leads to elevated membrane sulfatide availability, and thus, hypoxic mature erythrocyte adhesion. We found that mature erythrocyte adhesion to laminin in controlled microfluidic experiments is significantly greater under hypoxia than under normoxia (1856 ± 481 vs 78 ± 23, mean ± SEM), whereas sickle reticulocyte (early erythrocyte) adhesion, high to begin with, does not change (1281 ± 299 vs 1258 ± 328, mean ± SEM). We showed that greater mean accumulated bending energy of adhered mature erythrocytes was associated with higher acid SMase activity and increased mature erythrocyte adhesion (P = .022, for acid SMase activity and P = .002 for the increase in mature erythrocyte adhesion with hypoxia, N = 5). In addition, hypoxia results in sulfatide exposure of the erythrocyte membrane, and an increase in SMase, whereas anti-sulfatide inhibits enhanced adhesion of erythrocytes. These results suggest that the lipid components of the plasma membrane contribute to SCD complications. Therefore, sulfatide and the components of its upregulation pathway, particularly SMase, should be further explored as potential therapeutic targets for inhibiting sickle erythrocyte adhesion., (© 2023 by The American Society of Hematology. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.)

Published
2023
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50. Donor heart selection: Evidence-based guidelines for providers.

Author

Copeland H, Knezevic I, Baran DA, Rao V, Pham M, Gustafsson F, Pinney S, Lima B, Masetti M, Ciarka A, Rajagopalan N, Torres A, Hsich E, Patel JK, Goldraich LA, Colvin M, Segovia J, Ross H, Ginwalla M, Sharif-Kashani B, Farr MA, Potena L, Kobashigawa J, Crespo-Leiro MG, Altman N, Wagner F, Cook J, Stosor V, Grossi PA, Khush K, Yagdi T, Restaino S, Tsui S, Absi D, Sokos G, Zuckermann A, Wayda B, Felius J, and Hall SA

Subjects
Humans, Donor Selection, Brain Death, Consensus, Tissue Donors, Heart Transplantation
Abstract

The proposed donor heart selection guidelines provide evidence-based and expert-consensus recommendations for the selection of donor hearts following brain death. These recommendations were compiled by an international panel of experts based on an extensive literature review., (Copyright © 2022 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.)

Published
2023
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