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2. Effect of radiotherapy on local recurrence, distant metastasis and overall survival in 1200 extremity soft tissue sarcoma patients. Retrospective analysis using IPTW-adjusted models

Author

Smolle, Maria A., Andreou, Dimosthenis, Wölfel, Judith, Acem, Ibtissam, Aj Van De Sande, Michiel, Jeys, Lee, Bonenkamp, Han, Pollock, Rob, Tunn, Per-Ulf, Haas, Rick, Posch, Florian, Van Ginkel, Robert J., Verhoef, Cornelis, Liegl-Atzwanger, Bernadette, Moustafa-Hubmer, Dalia, Jost, Philipp J., Leithner, Andreas, and Szkandera, Joanna

Published
2023
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3. Health-related Quality of Life of Patients With Non–Intra-abdominal Desmoid-Type Fibromatosis During Active Surveillance: Results of a Prospective Observational Study

Author

Schut, Anne-Rose W., Timbergen, Milea J.M., Nasserinejad, Kazem, van Dalen, Thijs, van Houdt, Winan J., Bonenkamp, Johannes J., Sleijfer, Stefan, Grünhagen, Dirk J., Verhoef, Cornelis, Husson, Olga, Schut, Anne-Rose W., Timbergen, Milea J.M., van Broekhoven, Danique L.M., Sleijfer, Stefan, Grünhagen, Dirk J., Verhoef, Cornelis, van Houdt, Winan J., van Coevorden, Frits, van Dalen, Thijs, van der Hage, Jos. A., Dijkstra, Sander D.S., Bonenkamp, Johannes J., Been, Lukas B., van Ginkel, Robert J., and Bemelmans, Marc H.A.

Published
2023
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4. Age-related differences of oncological outcomes in primary extremity soft tissue sarcoma: a multistate model including 6260 patients

Author

Aston, Will, Bonenkamp, Han, Desar, Ingrid M.E., Ferguson, Peter C., Fiocco, Marta, Gelderblom, Hans, van Ginkel, Robert J., van der Graaf, Winette, Griffin, Anthony M., Haas, Rick L., van der Hage, Jos A., Hayes, Andrew J., Jeys, Lee M., Keller, Johnny, Laitinen, Minna K., Leithner, Andreas, Maretty-Kongstad, Katja, Ozaki, Toshifumi, Pollock, Rob, van Praag, Veroniek M., Smith, Myles J., Smolle, Maria A., Styring, Emelie, Szkandera, Joanna, Tanaka, Kazuhiro, Tunn, Per-Ulf, Willegger, Madeleine, Windhager, Reinard, Wunder, Jay S., Zaikova, Olga, Acem, Ibtissam, Verhoef, Cornelis, Rueten-Budde, Anja J., Grünhagen, Dirk J., van Houdt, Winan J., and van de Sande, Michiel A.J.

Published
2020
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6. Changes in Health-Related Quality of Life following Surgery in Patients with High-Grade Extremity Soft-Tissue Sarcoma: A Prospective Longitudinal Study

Author

Kruiswijk, Anouk (author), Sande, MAJ van de (author), Verhoef, Cornelis (author), Schrage, Yvonne M. (author), Haas, Rick L (author), Bemelmans, Marc H. A. (author), van Ginkel, Robert J. (author), Bonenkamp, Johannes J. (author), Witkamp, Arjen J. (author), van den Akker-van Marle, M. Elske (author), Marang-van de Mheen, P.J. (author), van Bodegom-Vos, Leti (author), Kruiswijk, Anouk (author), Sande, MAJ van de (author), Verhoef, Cornelis (author), Schrage, Yvonne M. (author), Haas, Rick L (author), Bemelmans, Marc H. A. (author), van Ginkel, Robert J. (author), Bonenkamp, Johannes J. (author), Witkamp, Arjen J. (author), van den Akker-van Marle, M. Elske (author), Marang-van de Mheen, P.J. (author), and van Bodegom-Vos, Leti (author)

Abstract

Introduction: Changes in health-related quality of life (HRQoL) during the diagnostic and treatment trajectory of high-grade extremity soft-tissue sarcoma (eSTS) has rarely been investigated for adults (18–65 y) and the elderly (aged ≥65 y), despite a potential variation in challenges from diverse levels of physical, social, or work-related activities. This study assesses HRQoL from time of diagnosis to one year thereafter among adults and the elderly with eSTS. Methods: HRQoL of participants from the VALUE-PERSARC trial (n = 97) was assessed at diagnosis and 3, 6 and 12 months thereafter, utilizing the PROMIS Global Health (GH), PROMIS Physical Function (PF) and EQ-5D-5L. Results: Over time, similar patterns were observed in all HRQoL measures, i.e., lower HRQoL scores than the Dutch population at baseline (PROMIS-PF:46.8, PROMIS GH-Mental:47.3, GH-Physical:46.2, EQ-5D-5L:0.76, EQ-VAS:72.6), a decrease at 3 months, followed by an upward trend to reach similar scores as the general population at 12 months (PROMIS-PF:49.9, PROMIS GH-Physical:50.1, EQ-5D-5L:0.84, EQ-VAS:81.5), except for the PROMIS GH-Mental (47.5), where scores remained lower than the general population mean (T = 50). Except for the PROMIS-PF, no age-related differences were observed. Conclusions: On average, eSTS patients recover well physically from surgery, yet the mental component demonstrates no progression, irrespective of age. These results underscore the importance of comprehensive care addressing both physical and mental health., Safety and Security Science

Published
2024
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7. Changes in Health-Related Quality of Life following Surgery in Patients with High-Grade Extremity Soft-Tissue Sarcoma: A Prospective Longitudinal Study

Author

MS CGO, Cancer, Kruiswijk, Anouk A., van de Sande, Michiel A.J., Verhoef, Cornelis, Schrage, Yvonne M., Haas, Rick L., Bemelmans, Marc H.A., van Ginkel, Robert J., Bonenkamp, Johannes J., Witkamp, Arjen J., van den Akker-van Marle, M. Elske, Marang-van de Mheen, Perla J., van Bodegom-Vos, Leti, MS CGO, Cancer, Kruiswijk, Anouk A., van de Sande, Michiel A.J., Verhoef, Cornelis, Schrage, Yvonne M., Haas, Rick L., Bemelmans, Marc H.A., van Ginkel, Robert J., Bonenkamp, Johannes J., Witkamp, Arjen J., van den Akker-van Marle, M. Elske, Marang-van de Mheen, Perla J., and van Bodegom-Vos, Leti

Published
2024

8. Changes in Health-Related Quality of Life following Surgery in Patients with High-Grade Extremity Soft-Tissue Sarcoma:A Prospective Longitudinal Study

Author

Kruiswijk, Anouk A., van de Sande, Michiel A. J., Verhoef, Cornelis, Schrage, Yvonne M., Haas, Rick L., Bemelmans, Marc H. A., van Ginkel, Robert J., Bonenkamp, Johannes J., Witkamp, Arjen J., van den Akker-van Marle, M. Elske, Marang-van de Mheen, Perla J., van Bodegom-Vos, Leti, Kruiswijk, Anouk A., van de Sande, Michiel A. J., Verhoef, Cornelis, Schrage, Yvonne M., Haas, Rick L., Bemelmans, Marc H. A., van Ginkel, Robert J., Bonenkamp, Johannes J., Witkamp, Arjen J., van den Akker-van Marle, M. Elske, Marang-van de Mheen, Perla J., and van Bodegom-Vos, Leti

Abstract

Introduction: Changes in health-related quality of life (HRQoL) during the diagnostic and treatment trajectory of high-grade extremity soft-tissue sarcoma (eSTS) has rarely been investigated for adults (18–65 y) and the elderly (aged ≥65 y), despite a potential variation in challenges from diverse levels of physical, social, or work-related activities. This study assesses HRQoL from time of diagnosis to one year thereafter among adults and the elderly with eSTS. Methods: HRQoL of participants from the VALUE-PERSARC trial (n = 97) was assessed at diagnosis and 3, 6 and 12 months thereafter, utilizing the PROMIS Global Health (GH), PROMIS Physical Function (PF) and EQ-5D-5L. Results: Over time, similar patterns were observed in all HRQoL measures, i.e., lower HRQoL scores than the Dutch population at baseline (PROMIS-PF:46.8, PROMIS GH-Mental:47.3, GH-Physical:46.2, EQ-5D-5L:0.76, EQ-VAS:72.6), a decrease at 3 months, followed by an upward trend to reach similar scores as the general population at 12 months (PROMIS-PF:49.9, PROMIS GH-Physical:50.1, EQ-5D-5L:0.84, EQ-VAS:81.5), except for the PROMIS GH-Mental (47.5), where scores remained lower than the general population mean (T = 50). Except for the PROMIS-PF, no age-related differences were observed. Conclusions: On average, eSTS patients recover well physically from surgery, yet the mental component demonstrates no progression, irrespective of age. These results underscore the importance of comprehensive care addressing both physical and mental health.

Published
2024

13. Changes in Health-Related Quality of Life Following Surgery in Patients with High-Grade Extremity Soft-Tissue Sarcoma: A Prospective Longitudinal Study

Author

Kruiswijk, Anouk A., primary, van de Sande, Michiel A. J., additional, Verhoef, Cornelis, additional, Schrage, Yvonne M., additional, Haas, Rick L., additional, Bemelmans, Marc H. A., additional, van Ginkel, Robert J., additional, Bonenkamp, Johannes J., additional, Witkamp, Arjen J., additional, van den Akker-van Marle, M. Elske, additional, Marang-van de Mheen, Perla J., additional, and van Bodegom-Vos, Leti, additional

Published
2024
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14. Impact of Synchronous Versus Metachronous Onset of Colorectal Peritoneal Metastases on Survival Outcomes After Cytoreductive Surgery (CRS) with Hyperthermic Intraperitoneal Chemotherapy (HIPEC): A Multicenter, Retrospective, Observational Study

Author

Hentzen, Judith E. K. R., Rovers, Koen P., Kuipers, Hendrien, van der Plas, Willemijn Y., Been, Lukas B., Hoogwater, Frederik J. H., van Ginkel, Robert J., Hemmer, Patrick H. J., van Dam, Gooitzen M., de Hingh, Ignace H. J. T., and Kruijff, Schelto

Published
2019
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15. Local treatment in metastatic GIST patients: A multicentre analysis from the Dutch GIST Registry

Author

Brink, Pien, primary, Kalisvaart, Gijsbert M., additional, Schrage, Yvonne M., additional, Mohammadi, Mahmoud, additional, Ijzerman, Nikki S., additional, Bleckman, Roos F., additional, Wal, Tom, additional, de Geus-Oei, Lioe-Fee, additional, Hartgrink, Henk H., additional, Grunhagen, Dirk J., additional, Verhoef, Cornelis, additional, Sleijfer, Stefan, additional, Oosten, Astrid W., additional, Been, Lukas B., additional, van Ginkel, Robert J., additional, Reyners, An K.L., additional, Bonenkamp, Han J., additional, Desar, Ingrid M.E., additional, Gelderblom, Hans, additional, van Houdt, Winan J., additional, Steeghs, Neeltje, additional, Fiocco, Marta, additional, and van der Hage, Jos A., additional

Published
2023
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16. Molecular fluorescence-guided surgery of peritoneal carcinomatosis of colorectal origin: a single-centre feasibility study

Author

Harlaar, Niels J, Koller, Marjory, de Jongh, Steven J, van Leeuwen, Barbara L, Hemmer, Patrick H, Kruijff, Schelto, van Ginkel, Robert J, Been, Lukas B, de Jong, Johannes S, Kats-Ugurlu, Gursah, Linssen, Matthijs D, Jorritsma-Smit, Annelies, van Oosten, Marleen, Nagengast, Wouter B, Ntziachristos, Vasilis, and van Dam, Gooitzen M

Published
2016
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17. Perioperative systemic therapy and cytoreductive surgery with HIPEC versus upfront cytoreductive surgery with HIPEC alone for isolated resectable colorectal peritoneal metastases: protocol of a multicentre, open-label, parallel-group, phase II-III, randomised, superiority study (CAIRO6)

Author

Rovers, Koen P., Bakkers, Checca, Simkens, Geert A. A. M., Burger, Jacobus W. A., Nienhuijs, Simon W., Creemers, Geert-Jan M., Thijs, Anna M. J., Brandt-Kerkhof, Alexandra R. M., Madsen, Eva V. E., Ayez, Ninos, de Boer, Nadine L., van Meerten, Esther, Tuynman, Jurriaan B., Kusters, Miranda, Sluiter, Nina R., Verheul, Henk M. W., van der Vliet, Hans J., Wiezer, Marinus J., Boerma, Djamila, Wassenaar, Emma C. E., Los, Maartje, Hunting, Cornelis B., Aalbers, Arend G. J., Kok, Niels F. M., Kuhlmann, Koert F. D., Boot, Henk, Chalabi, Myriam, Kruijff, Schelto, Been, Lukas B., van Ginkel, Robert J., de Groot, Derk Jan A., Fehrmann, Rudolf S. N., de Wilt, Johannes H. W., Bremers, Andreas J. A., de Reuver, Philip R., Radema, Sandra A., Herbschleb, Karin H., van Grevenstein, Wilhelmina M. U., Witkamp, Arjen J., Koopman, Miriam, Haj Mohammad, Nadia, van Duyn, Eino B., Mastboom, Walter J. B., Mekenkamp, Leonie J. M., Nederend, Joost, Lahaye, Max J., Snaebjornsson, Petur, Verhoef, Cornelis, van Laarhoven, Hanneke W. M., Zwinderman, Aeilko H., Bouma, Jeanette M., Kranenburg, Onno, van ‘t Erve, Iris, Fijneman, Remond J. A., Dijkgraaf, Marcel G. W., Hemmer, Patrick H. J., Punt, Cornelis J. A., Tanis, Pieter J., and de Hingh, Ignace H. J. T.

Published
2019
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19. Local treatment in metastatic GIST patients:A multicentre analysis from the Dutch GIST Registry

Author

Brink, Pien, Kalisvaart, Gijsbert M., Schrage, Yvonne M., Mohammadi, Mahmoud, Ijzerman, Nikki S., Bleckman, Roos F., Wal, Tom, de Geus-Oei, Lioe Fee, Hartgrink, Henk H., Grunhagen, Dirk J., Verhoef, Cornelis, Sleijfer, Stefan, Oosten, Astrid W., Been, Lukas B., van Ginkel, Robert J., Reyners, An K.L., Bonenkamp, Han J., Desar, Ingrid M.E., Gelderblom, Hans, van Houdt, Winan J., Steeghs, Neeltje, Fiocco, Marta, van der Hage, Jos A., Brink, Pien, Kalisvaart, Gijsbert M., Schrage, Yvonne M., Mohammadi, Mahmoud, Ijzerman, Nikki S., Bleckman, Roos F., Wal, Tom, de Geus-Oei, Lioe Fee, Hartgrink, Henk H., Grunhagen, Dirk J., Verhoef, Cornelis, Sleijfer, Stefan, Oosten, Astrid W., Been, Lukas B., van Ginkel, Robert J., Reyners, An K.L., Bonenkamp, Han J., Desar, Ingrid M.E., Gelderblom, Hans, van Houdt, Winan J., Steeghs, Neeltje, Fiocco, Marta, and van der Hage, Jos A.

Abstract

Background: The added value of local treatment in selected metastatic GIST patients is unclear. This study aims to provide insight into the usefulness of local treatment in metastatic GIST by use of a survey study and retrospective analyses in a clinical database. Methods: A survey study was conducted among clinical specialists to select most relevant characteristics of metastatic GIST patients considered for local treatment, defined as elective surgery or ablation. Patients were selected from the Dutch GIST Registry. A multivariate Cox-regression model for overall survival since time of diagnosis of metastatic disease was estimated with local treatment as a time-dependent variable. An additional model was estimated to assess prognostic factors since local treatment. Results: The survey's response rate was 14/16. Performance status, response to TKIs, location of active disease, number of lesions, mutation status, and time between primary diagnosis and metastases, were regarded the 6 most important characteristics. Of 457 included patients, 123 underwent local treatment, which was associated with better survival after diagnosis of metastases (HR = 0.558, 95%CI = 0.336–0.928). Progressive disease during systemic treatment (HR = 3.885, 95%CI = 1.195–12.627) and disease confined to the liver (HR = 0.269, 95%CI = 0.082–0.880) were associated with worse and better survival after local treatment, respectively. Conclusion: Local treatment is associated with better survival in selected patients with metastatic GIST. Locally treated patients with response to TKIs and disease confined to the liver have good clinical outcome. These results might be considered for tailoring treatment, but should be interpreted with care because only specific patients are provided with local treatment in this retrospective study.

Published
2023

23. Impact of cumulative complications on 1-year treatment-related healthcare costs in patients with colorectal peritoneal metastases undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy

Author

van der Zant, Femke A, primary, Kooijman, Bob J L, additional, Hentzen, Judith E K R, additional, Helfrich, Wijnand, additional, Ploeg, Emily M, additional, van Ginkel, Robert J, additional, van Leeuwen, Barbara L, additional, Been, Lukas B, additional, Klaase, Joost M, additional, Hemmer, Patrick H J, additional, van der Hilst, Christian S, additional, and Kruijff, Schelto, additional

Published
2022
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24. External validation and adaptation of a dynamic prediction model for patients with high-grade extremity soft tissue sarcoma

Author

PERSARC Study Group, Rueten-Budde, Anja J., van Praag, Veroniek M., van de Sande, Michiel A. J., Fiocco, Marta, Aston, Will, Bonenkamp, Han, Callegaro, Dario, Dijkstra, P. D. Sander, Ferguson, Peter C., Griffin, Anthony M., Gronchi, Alessandro, Grünhagen, Dirk, Haas, Rick, Hayes, Andrew, Jeys, Lee M, Keller, Johnny, Laitinen, Minna K., Leithner, Andreas, Maretty-Kongstad, Katja, Pollock, Rob, Posch, Florian, Smith, Myles, Smolle, Maria, Styring, Emelie, Tunn, Per-Ulf, van der Hage, Jos A., van Ginkel, Robert, van Houdt, Winan, Verhoef, Kees, Willegger, Madeleine, Willeumier, Julie J., Windhager, Reinhard, Wunder, Jay S., Zaikova, Olga, HUS Musculoskeletal and Plastic Surgery, I kirurgian klinikka (Töölö), Department of Surgery, and Surgery

Subjects
Male, medicine.medical_specialty, Dynamic prediction, Calibration (statistics), survival, 03 medical and health sciences, 0302 clinical medicine, external validation, medicine, Humans, Model development, Time point, Retrospective Studies, Models, Statistical, business.industry, Soft tissue sarcoma, Melanoma/Sarcoma, External validation, dynamic prediction, Extremities, Sarcoma, General Medicine, Middle Aged, medicine.disease, 3126 Surgery, anesthesiology, intensive care, radiology, 3. Good health, Survival Rate, Nomograms, landmark analysis, Oncology, 030220 oncology & carcinogenesis, soft tissue sarcoma, Cohort, 030211 gastroenterology & hepatology, Surgery, Female, Radiology, Neoplasm Grading, Neoplasm Recurrence, Local, business, Follow-Up Studies
Abstract

Background and Objectives: A dynamic prediction model for patients with soft tissue sarcoma of the extremities was previously developed to predict updated overall survival probabilities throughout patient follow‐up. This study updates and externally validates the dynamic model. Methods: Data from 3826 patients with high‐grade extremity soft tissue sarcoma, treated surgically with curative intent were used to update the dynamic PERsonalised SARcoma Care (PERSARC) model. Patients were added to the model development cohort and grade was included in the model. External validation was performed with data from 1111 patients treated at a single tertiary center. Results: Calibration plots show good model calibration. Dynamic C‐indices suggest that the model can discriminate between high‐ and low‐risk patients. The dynamic C‐indices at 0, 1, 2, 3, 4, and 5 years after surgery were equal to 0.697, 0.790, 0.822, 0.818, 0.812, and 0.827, respectively. Conclusion: Results from the external validation show that the dynamic PERSARC model is reliable in predicting the probability of surviving an additional 5 years from a specific prediction time point during follow‐up. The model combines patient‐, treatment‐specific and time‐dependent variables such as local recurrence and distant metastasis to provide accurate survival predictions throughout follow‐up and is available through the PERSARC app.

Published
2021
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27. The role of perioperative chemotherapy in primary high-grade extremity soft tissue sarcoma: a risk-stratified analysis using PERSARC

Author

Acem, Ibtissam, primary, van Houdt, Winan J., additional, Grünhagen, Dirk J., additional, van der Graaf, Winette T.A., additional, Rueten-Budde, Anja J., additional, Gelderblom, Hans, additional, Verhoef, Cornelis, additional, van de Sande, Michiel A.J., additional, Aston, Will, additional, Bonenkamp, Han, additional, Desar, Ingrid M.E., additional, Ferguson, Peter C., additional, Fiocco, Marta, additional, van Ginkel, Robert J., additional, Griffin, Anthony M., additional, Haas, Rick L., additional, van der Hage, Jos A., additional, Hayes, Andrew J., additional, Jeys, Lee M., additional, Kawai, Akira, additional, Keller, Johnny, additional, Laitinen, Minna K., additional, Maretty-Kongstad, Katja, additional, Ogura, Koichi, additional, Ozaki, Toshifumi, additional, Pollock, Rob, additional, van Praag, Veroniek M., additional, Sleijfer, Stefan, additional, Smith, Myles J., additional, Smolle, Maria A., additional, Styring, Emelie, additional, Szkandera, Joanna, additional, Tanaka, Kazuhiro, additional, Tunn, Per-Ulf, additional, Willegger, Madeleine, additional, Windhager, Reinard, additional, Wunder, Jay S., additional, and Zaikova, Olga, additional

Published
2022
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29. Corrigendum to ‘Age-related differences of oncological outcomes in primary extremity soft tissue sarcoma: a multistate model including 6260 patients’ [Eur J Cancer 141 (2020) 128-136]

Author

Acem, Ibtissam, primary, Verhoef, Cornelis, additional, Rueten-Budde, Anja J., additional, Grünhagen, Dirk J., additional, van Houdt, Winan J., additional, van de Sande, Michiel A.J., additional, Aston, Will, additional, Bonenkamp, Han, additional, Desar, Ingrid M.E., additional, Ferguson, Peter C., additional, Fiocco, Marta, additional, Gelderblom, Hans, additional, van Ginkel, Robert J., additional, van der Graaf, Winette, additional, Griffin, Anthony M., additional, Haas, Rick L., additional, van der Hage, Jos A., additional, Hayes, Andrew J., additional, Jeys, Lee M., additional, Keller, Johnny, additional, Laitinen, Minna K., additional, Leithner, Andreas, additional, Maretty-Kongstad, Katja, additional, Ozaki, Toshifumi, additional, Pollock, Rob, additional, van Praag, Veroniek M., additional, Smith, Myles J., additional, Smolle, Maria A., additional, Styring, Emelie, additional, Szkandera, Joanna, additional, Tanaka, Kazuhiro, additional, Tunn, Per-Ulf, additional, Willegger, Madeleine, additional, Windhager, Reinard, additional, Wunder, Jay S., additional, and Zaikova, Olga, additional

Published
2022
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30. A nationwide prospective clinical trial on active surveillance in patients with non-intra-abdominal desmoid-type fibromatosis; the Grafiti trial

Author

Schut, Anne-Rose, primary, Timbergen, Milea, additional, van Broekhoven, Danique, additional, van Dalen, Thijs, additional, van Houdt, Winan, additional, van Coevorden, Frits, additional, Bonenkamp, Johannes, additional, Dijkstra, Sander, additional, Bemelmans, Marc, additional, Been, Lukas, additional, van Ginkel, Robert, additional, Sleijfer, Stefan, additional, Grünhagen, Dirk, additional, and Verhoef, Cornelis, additional

Published
2022
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38. Impact of cumulative complications on 1-year treatment-related healthcare costs in patients with colorectal peritoneal metastases undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy.

Author

Zant, Femke A van der, Kooijman, Bob J L, Hentzen, Judith E K R, Helfrich, Wijnand, Ploeg, Emily M, Ginkel, Robert J van, Leeuwen, Barbara L van, Been, Lukas B, Klaase, Joost M, Hemmer, Patrick H J, Hilst, Christian S van der, and Kruijff, Schelto

Subjects
HYPERTHERMIC intraperitoneal chemotherapy, CYTOREDUCTIVE surgery, MEDICAL care costs, CHI-squared test, KRUSKAL-Wallis Test
Abstract

Background The aim of this study was to evaluate the impact of all minor and major complications on treatment-related healthcare costs in patients who undergo cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) for the treatment of colorectal peritoneal metastases (PMs). Method Patients with histologically proven colorectal PMs who underwent CRS + HIPEC from March 2006 to October 2019 in a tertiary referral centre were retrospectively identified from a prospectively maintained database. Patients were divided into six subgroups according to the severity of the complications, which were scored using the comprehensive complication index (CCI) (CCI 0–9.9, CCI 10–19.9, CCI 20–29.9, CCI 30–39.9, CCI 40–49.9, and CCI 50 or higher). Treatment-related healthcare costs up to 1 year after CRS + HIPEC were obtained from the financial department. Differences in costs and survival outcomes were compared using the chi-squared test and Kruskal–Wallis H test. Results A total of 142 patients were included (CCI 0–9.9, 53 patients; CCI 10–19.9, 0 patients; CCI 20–29.9, 45 patients; CCI 30–39.9, 14 patients; CCI 40–49, 9 patients; and CCI 50 or higher, 21 patients). Median (interquartile range) treatment-related healthcare costs increased significantly and exponentially for the CCI 30–39, CCI 40–49, and CCI 50 or higher groups (€48 993 (€44 262–€84 805); €57 167 (€43 047–€67 591); and €82 219 (€55 487–€145 314) respectively) compared with those for the CCI 0–9.9 and CCI 20–29.9 groups (€33 856 (€24 433–€40 779) and €40 621 (€31 501–€58 761) respectively, P  < 0.010). Conclusion Treatment-related healthcare costs increase exponentially as more complications develop among patients who undergo CRS + HIPEC for the treatment of colorectal PMs. Anastomotic leakages after CRS + HIPEC lead to an increase of 295 per cent of treatment-related healthcare costs. [ABSTRACT FROM AUTHOR]

Published
2022
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48. Age-related differences of oncological outcomes in primary extremity soft tissue sarcoma: a multistate model including 6260 patients

Author

Acem, Ibtissam, primary, Verhoef, Cornelis, additional, Rueten-Budde, Anja J., additional, Grünhagen, Dirk J., additional, van Houdt, Winan J., additional, van de Sande, Michiel A.J., additional, Aston, Will, additional, Bonenkamp, Han, additional, Desar, Ingrid M.E., additional, Ferguson, Peter C., additional, Fiocco, Marta, additional, Gelderblom, Hans, additional, van Ginkel, Robert J., additional, van der Graaf, Winette, additional, Griffin, Anthony M., additional, Haas, Rick L., additional, van der Hage, Jos A., additional, Hayes, Andrew J., additional, Jeys, Lee M., additional, Keller, Johnny, additional, Laitinen, Minna K., additional, Leithner, Andreas, additional, Maretty-Kongstad, Katja, additional, Ozaki, Toshifumi, additional, Pollock, Rob, additional, van Praag, Veroniek M., additional, Smith, Myles J., additional, Smolle, Maria A., additional, Styring, Emelie, additional, Szkandera, Joanna, additional, Tanaka, Kazuhiro, additional, Tunn, Per-Ulf, additional, Willegger, Madeleine, additional, Windhager, Reinard, additional, Wunder, Jay S., additional, and Zaikova, Olga, additional

Published
2020
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49. Fluorescence-Guided Visualization of Soft-Tissue Sarcomas by Targeting Vascular Endothelial Growth Factor A: A Phase 1 Single-Center Clinical Trial

Author

Steinkamp, Pieter J., primary, Pranger, Bobby K., additional, Li, Mei-Fang, additional, Linssen, Matthijs D., additional, Voskuil, Floris J., additional, Been, Lukas B., additional, van Leeuwen, Barbara L., additional, Suurmeijer, Albert J.H., additional, Nagengast, Wouter B., additional, Kruijff, Schelto, additional, van Ginkel, Robert J., additional, and van Dam, Gooitzen M., additional

Published
2020
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50. Delta peritoneal cancer index (ΔPCI): A new dynamic prognostic parameter for survival in patients with colorectal peritoneal metastases

Author

Hentzen, Judith E.K.R., primary, van der Plas, Willemijn Y., additional, Kuipers, Hendrien, additional, Ramcharan, Swades, additional, Been, Lukas B., additional, Hoogwater, Frederik J.H., additional, van Ginkel, Robert J., additional, van Dam, Gooitzen M., additional, Hemmer, Patrick H.J., additional, and Kruijff, Schelto, additional

Published
2020
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