631 results on '"Gingival Hypertrophy"'
Search Results
2. Efficacy of Hyaluronic Acid Gel and Photobiomodulation on Wound Healing After Surgical Gingivectomy
- Author
-
Basma Khalil, Resident of Periodontology
- Published
- 2023
3. Amlodipine Bağlı Aşırı Diş Eti Büyümesinin Cerrahi Olmayan Periodontal Tedavisi.
- Author
-
YEĞİNOĞLU, Sevilay
- Abstract
Drug-induced gingival enlargement is proportional to the inflammation caused by poor oral hygiene. In this case report, gingival enlargement due to the use of the antihypertensive drug amlodipine, which is a Ca channel blocker derivative, is presented. In the anamnesis taken from a 56-year-old female patient who applied to Ankara University Faculty of Dentistry Periodontology Department with complaints of swollen and bleeding gingival enlargements, pain and discomfort when chewing, it was learned that she had been using 10 mg amlodipine (Norvasc®, Pfizer, USA) daily for 6 years due to hypertension. During clinical examination, it was determined that the patient had poor oral hygiene and the presence of gingival growths. In the patient's treatment, the hypertension medication was first changed to an alternative with cardiology consultation. The patient underwent scaling, root planing and oral hygiene training. Growth regression was observed at the patient's 1st, 3rd and 6th month follow-up visits. Following medication change and non-surgical periodontal treatment, at the 1-year followup, the gingival growths had completely regressed, no bleeding was detected on probing, and plaque control was achieved. The patient gained oral hygiene habits and left satisfied. In cases of gingival enlargement due to amlodipine use, drug replacement, scaling, root planing, plaque control, oral hygiene motivation and regular patient follow-up play a key role in the treatment of these diseases. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
4. European Alpha-Mannosidosis Participant (EUMAP)
- Published
- 2022
5. Surgical treatment of hereditary gingival fibromatosis by diode laser: Report of five rare cases in the same family.
- Author
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Bektaş‐Kayhan, Kıvanç, Selvi, Fırat, and Koca‐Ünsal, Revan Birke
- Subjects
SEMICONDUCTOR lasers ,FIBROMAS ,GINGIVA ,ORAL hygiene ,DENTAL plaque - Abstract
The pathogenesis of hereditary gingival fibromatosis (HGF) is largely unknown; however, the removal of excess tissue may often be necessary as it often causes aesthetic and functional problems. Gingivectomy is usually a treatment option that can be performed using a scalpel, cryotherapy, electrosurgery, or laser. This paper aims to evaluate the results of HGF treatments using a diode laser of five people from the same family. Three members of a family of five (two females and three males; 9–36 years old) underwent gingivectomy with a 3 W 300‐micron fiber‐tipped diode laser (Doctor Smile, Vicenza, Italy) at 810 nm wavelength. While all teeth of one member were extracted, the other member refused treatment. Relapse occurred in three members due to poor oral hygiene. The diode laser was reapplied and oral hygiene instructions were repeated. Patients were followed during the postoperative period for up to two years. HGF is a rare condition that clinicians should pay attention to in the diagnosis, treatment, and follow‐ups. Since recurrences are due to dental plaque, oral hygiene instructions are essential and compliance is mandatory. Although there are many treatment approaches, the diode laser is the most indicated method due to many advantages such as providing a bloodless and more sterile operation field, performing an atraumatic surgery, ensuring earlier and ideal recovery, and minimizing postoperative pain. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
6. Difficult to think about but easy to treat: scurvy.
- Author
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Küçükçongar Yavaş, Aynur, Engin Erdal, Ayşenur, Çıtak Kurt, Ayşegül Neşe, Kurt, Tuba, Cankurt, İlknur, and Ünal Uzun, Özlem
- Abstract
Severe vitamin C deficiency, or scurvy, presents as a syndrome of multisystem abnormalities associated with defective collagen synthesis and antioxidative functions. The many clinical features of scurvy lead to frequent misdiagnoses, as they can often point to other diseases, such as vasculitis, venous thrombosis and musculoskeletal disorders. As such, an extensive workup is recommended in cases in which scurvy is suspected. A 21-month-old male patient and a 36-month-old female patient presented with difficulty in walking, painful joint movements, irritability, gingival hypertrophy and bleeding. After exhaustive investigations and risky invasive procedures, vitamin C deficiency was diagnosed in both cases, and the symptoms improved dramatically with vitamin C treatment. The importance of taking a dietary history in pediatric patients is highly recommended. In cases where scurvy is considered, serum ascorbic acid levels should be checked to confirm the diagnosis prior to conducting invasive tests. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
7. Different Platelet Concentrates After Gingivectomy and Gingivoplasty Evaluation of Its Effect on Early Wound Healing.
- Author
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Esra Bozkurt, RA
- Published
- 2021
8. Evaluation of Healing Process After Laser Asissted Gingivectomy Techniques
- Author
-
mehmet murat taskan, Assistant Professor
- Published
- 2020
9. DIODE LASER IN ORTHODONTICS – CASE PRESENTATIONS
- Author
-
Adriana Vasilache, Anca-Oana Dragomirescu, Cristina-Crenguța Albu, Bartok-Nicolae Cristina, Andrei Vasilache, Maria -Angelica Bencze, and Ecaterina Ionescu
- Subjects
940 nm diode laser ,orthodontic treatment ,soft tissue management ,canine impaction ,gingival hypertrophy ,Dentistry ,RK1-715 - Published
- 2022
10. Temperature and Healing in Treatment of Gingival Enlargement
- Author
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mehmet murat taskan, Assistant Professor
- Published
- 2019
11. Successful Management of an Emerging Distinct Gingival Lesion With a New Histopathological Identity.
- Author
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Almutairi F
- Abstract
Gingival fibroma is a pathological condition that can manifest in pediatric and adult patients, often presenting diagnostic challenges due to shared histopathological characteristics among various lesions. It has been reported as a novel category with distinct histopathological features with new diagnostic criteria. A 40-year-old Saudi female patient with no significant medical history reported a 4×3 cm pedunculated, non-tender, firm, red gingival growth adjacent to the remaining root of tooth number 27 in the maxillary left side. Radiographic assessment yielded remarkable findings. An excisional biopsy was performed, and histopathology analysis confirmed the lesion to be a gingival fibroma. This case marks the first reported instance of gingival fibroma in Saudi Arabia. The recognition of such distinctive histopathological features contributes to improved diagnostic accuracy and highlights the need for vigilance in identifying emerging pathological entities within the gingival overgrowths. The recognition of gingival fibroma as a unique pathological entity is clinically significant, resolving diagnostic challenges in gingival growth cases. Specific diagnostic criteria enable accurate differentiation from similar lesions. The advancement improves patient care and refines the understanding of gingival overgrowth pathogenesis., Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Almutairi et al.)
- Published
- 2024
- Full Text
- View/download PDF
12. Host Microbiota Balance in Teenagers with Gum Hypertrophy Concomitant with Acne Vulgaris: Role of Oral Hygiene Associated with Topical Probiotics.
- Author
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Mosaico, Giovanna, Artuso, Giulia, Pinna, Mara, Denotti, Gloria, Orrù, Germano, and Casu, Cinzia
- Subjects
ACNE ,ORAL hygiene ,PROBIOTICS ,LACTOBACILLUS reuteri ,HYPERTROPHY ,TEENAGERS ,GINGIVA - Abstract
Gum hypertrophy is a very frequent condition linked to orthodontic treatment, especially in teenagers, and the same time, about 80% of young adults are affected by acne vulgaris, a chronic inflammatory skin disease, typically treated with antibacterial therapy. The use of probiotics has gained popularity in the medical field, and many studies have demonstrated its effectiveness, such as the positive effects of some bacterial strains belonging to Lactobacillus species. The aim of this study is to document the effect of Lactobacillus reuteri (L. reuteri) on facial skin that was randomly observed in two orthodontic patients. We present two case reports of a 14-year-old female patient and a 15-year-old male patient suffering from acne vulgaris who, during fixed orthodontic treatment, showed clinical signs of gingivitis with high values of Full Mouth Plaque Score (FMPS) and Bleeding on Probing (BOP). The patients were treated first with professional oral hygiene sessions and Scaling and Root Planing (SRP) procedures, and then with the administration of a formulate containing L. reuteri as a probiotic. The follow-up was made at four weeks. During the follow-up analysis, both patients showed a significant clinical remission for gum hypertrophy and skin acne vulgaris. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
13. Development and Validation of the Periodontal Aesthetic Perception Scale in Patients With Periodontal Problems
- Author
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Ozge Gokturk, asst. assoc.
- Published
- 2018
14. Test Yourself-Question: Multiple facial skin lesions associated with gingival hypertrophy in a pair of siblings.
- Author
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Marroun, Nour, Franck, Diane, Segers, Valérie, and Boitsios, Grammatina
- Subjects
- *
GINGIVA , *HYPERTROPHY , *SIBLINGS , *BROTHERS , *SCALP - Abstract
Two brothers, completely asymptomatic until their first year of life, started to complain from gingival hypertrophy, progressive development of painful soft tissue masses on the fingers and toes, on the face and on the scalp. There were no neurological symptoms or mental delay for both brothers. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
15. Expression of type III collagen in hypertrophic gingival tissue of patients with orthodontic treatment: a pilot study
- Author
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Víctor Hugo Simancas-Escorcia, Jocsan Steven Leal-Betancur, and Antonio Díaz-Caballero
- Subjects
gingival hypertrophy ,collagen ,immunohistochemistry ,orthodontics ,type iii collagen ,Dentistry ,RK1-715 - Abstract
Introduction: gingival hypertrophy (GH) is the uncontrolled increase in gingival volume induced by different etiological factors, including orthodontic treatment. This pathology is characterized by changes in epithelial and connective tissue, including modifications in the extracellular matrix. The present study determined the presence and distribution of type III collagen in tissues of patients with GH wearing fixed orthodontic appliances. Methods: 12 samples of gingival tissue were obtained from patients undergoing periodontal surgery. They were divided into two groups, the first with healthy patients (control; n = 6) and the second with patients diagnosed with GH and orthodontic treatment (patients; n = 6). Each obtained sample was subjected to the hematoxylin-eosin stain, Masson-Goldner staining, and type III collagen immunohistochemistry. Results: the hematoxylin-eosin and Masson-Goldner histological stains showed hypertrophia of epithelial tissue and connective tissue with a marked collagen fiber increase in the gingival tissue of orthodontic wearers with GH compared to individuals in the control group. The gingival tissue of patients with GH caused by orthodontic treatment showed a distribution and location of type III collagen near the basal lamina, around the blood vessels, but unlike the control group, its location was noticeable throughout the connective tissue. Conclusion: the gingival tissues of orthodontic wearers with GH experience an increase in the number and density of collagen fibers. Type III collagen seems to lose its usual location in the gingival tissues of orthodontic wearers with GH.
- Published
- 2020
- Full Text
- View/download PDF
16. Gingival Hypertrophy in a Child with Hyaline Fibromatosis Syndrome
- Author
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Predrag Knežević, Marko Tarle, Lucija Ida Fratrić, Antonia Tarle, Hana Knežević-Krajina, and Darko Macan
- Subjects
Systemic Hyalinosis ,Gingival Hypertrophy ,Gingivectomy ,Extracellular Matrix ,ANTXR2 gene ,Dentistry ,RK1-715 - Abstract
Hyaline fibromatosis syndrome (HFS) is a rare autosomal recessive genetic disorder characterized by accumulation of hyalinized fibrous tissue with cutaneous, mucosal, osteoarticular, and systemic involvement. The condition is caused by a mutation of ANTXR2 gene that results in a faulty synthesis of a transmembrane protein which leads up to excessive deposition of hyaline material in extracellular space. The first signs may be present at birth or appear during infancy, and joint stiffness is the first, most common, symptom. Other manifestations include joint contractures, hyperpigmented macules over bony prominences of the joints, and gingival hypertrophy. The symptom that raises suspicion of HFS is present later, along with subcutaneous growths. The progression of the disease includes enteropathy with extensive protein loss, chronic diarrhea and frequent infections. We present a case of a five-year-old girl with severe gingival hypertrophy that caused difficulties in eating and speaking. To the best of our knowledge, this is also the first patient in Croatia with a confirmed ANTXR2 gene mutation described in the literature.
- Published
- 2020
- Full Text
- View/download PDF
17. DIODE LASER IN ORTHODONTICS - CASE PRESENTATIONS.
- Author
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Vasilache, Adriana, Dragomirescu, Anca-Oana, Albu, Cristina-Crenguța, Cristina, Bartok- Nicolae, Vasilache, Andrei, Bencze, Maria -Angelica, and Ionescu, Ecaterina
- Subjects
HYPERTROPHIC scars ,SEMICONDUCTOR lasers ,LASERS ,THIRD molars ,CARBON dioxide lasers ,TEETH - Published
- 2021
18. Radboud University Medical Center Reports Findings in Gingival Hypertrophy (Exploring the Prevalence of Oral Features for Early Detection of PTEN Hamartoma Tumour Syndrome).
- Subjects
ACADEMIC medical centers ,GINGIVAL hyperplasia ,HAMARTOMA ,GINGIVA ,HYPERTROPHY ,TUMORS - Abstract
A report from Radboud University Medical Center in the Netherlands explores the prevalence of oral features for early detection of PTEN Hamartoma Tumour Syndrome (PHTS). PHTS is a rare condition that increases the risk of developing cancer due to a genetic variant. The study found that oral abnormalities, such as gingival hypertrophy and oral papillomas, were common in adult patients with PHTS. Dental professionals are well-positioned to recognize these oral manifestations and initiate early assessment, which could significantly improve patient outcomes. [Extracted from the article]
- Published
- 2024
19. Hereditary gingival fibromatosis in children: a systematic review of the literature.
- Author
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Boutiou, Eirini, Ziogas, Ioannis A., Giannis, Dimitrios, and Doufexi, Aikaterini-Elisavet
- Subjects
- *
GINGIVAL hyperplasia , *DISEASE relapse , *DIAGNOSIS , *ORAL hygiene , *GINGIVA - Abstract
Objectives: Hereditary gingival fibromatosis (HGF) is an uncommon, inherited condition with slow and progressive fibrous hyperplasia of the gingiva. Due to its association with mastication, speech, and occlusion problems, early diagnosis is important. We sought to summarize the available data regarding the epidemiology, clinical characteristics, and outcomes of children with HGF (< 18 years). Methods: A systematic literature review of the MEDLINE and Cochrane Library databases was conducted with respect to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement (end-of-search date: March 1, 2019). Results: A total of 99 articles reporting on 146 patients were included. The mean age was 10.82 ± 3.93 years, and generalized gingival enlargement was seen in 97.16% (95% CI 92.69 to 99.14). Jaw, gingival, and teeth abnormalities; poor oral hygiene; eating; or speech difficulties were typical HGF-induced, while 60.90% had extraoral manifestations (95% CI 52.41 to 68.78). The disease was most commonly inherited in an autosomal dominant manner (88.41%, 95% CI 78.5 to 94.26), and about one-third of the patients had syndromic HGF (33.85%, 95% CI 23.50 to 46.00). Gingivectomy was performed in the majority of cases (91.15%, 95% CI 84.31 to 95.29), and recurrence was seen in 33.85% (95% CI 23.50 to 46.00). Conclusion: HGF should be suspected in children with nodularity and gingival fibrosis, teeth abnormalities, or jaw distortion. Family history can help to establish the diagnosis. Clinical relevance: More cases should focus on longer-term follow-up after gingivectomy as disease recurrence is not uncommon. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
20. Host Microbiota Balance in Teenagers with Gum Hypertrophy Concomitant with Acne Vulgaris: Role of Oral Hygiene Associated with Topical Probiotics
- Author
-
Giovanna Mosaico, Giulia Artuso, Mara Pinna, Gloria Denotti, Germano Orrù, and Cinzia Casu
- Subjects
gingival hypertrophy ,acne vulgaris ,antibiotic resistance ,probiotics ,microbioma ,microbiota ,Biology (General) ,QH301-705.5 - Abstract
Gum hypertrophy is a very frequent condition linked to orthodontic treatment, especially in teenagers, and the same time, about 80% of young adults are affected by acne vulgaris, a chronic inflammatory skin disease, typically treated with antibacterial therapy. The use of probiotics has gained popularity in the medical field, and many studies have demonstrated its effectiveness, such as the positive effects of some bacterial strains belonging to Lactobacillus species. The aim of this study is to document the effect of Lactobacillus reuteri (L. reuteri) on facial skin that was randomly observed in two orthodontic patients. We present two case reports of a 14-year-old female patient and a 15-year-old male patient suffering from acne vulgaris who, during fixed orthodontic treatment, showed clinical signs of gingivitis with high values of Full Mouth Plaque Score (FMPS) and Bleeding on Probing (BOP). The patients were treated first with professional oral hygiene sessions and Scaling and Root Planing (SRP) procedures, and then with the administration of a formulate containing L. reuteri as a probiotic. The follow-up was made at four weeks. During the follow-up analysis, both patients showed a significant clinical remission for gum hypertrophy and skin acne vulgaris.
- Published
- 2022
- Full Text
- View/download PDF
21. IMMUNOLOCALIZACIÓN DE S100A4 Y Α-SMA EN TEJIDOS GINGIVALES DE PACIENTES CON HIPERTROFIA GINGIVAL POR TRATAMIENTO ORTODÓNTICO: ESTUDIO PRELIMINAR.
- Author
-
SIMANCAS-ESCORCIA, VÍCTOR, CARMONA-LORDUY, MARTHA, and DÍAZ-CABALLERO, ANTONIO
- Abstract
Objective: to determine the presence and distribution of markers of the epithelialmesenchymal transition (EMT) (S-100A4 and alpha-smooth muscle actin-α-SMA) in gingival tissues of patients affected by Gingival hypertrophy (GH) due to orthodontics. GH is an exaggerated increase in gingival tissue whose pathogenesis is unknown. However, it has been reported that the epithelial-mesenchymal transition as a process involved in other types of GH. Materials and methods: descriptive study that included the analysis of gingival tissues of healthy individuals (n = 6) and patients with GH by orthodontic treatment (n = 6). Before gingival surgery, the patients underwent a periodontal hygiene phase. The gingival tissue samples obtained were processed and embedded in paraffin. The cuts were made with a microtome and deposited on polysine adhesion slides. Histological hematoxylin-eosin staining was performed. The identification and location of S-100A4 and α-SMA markers was determined by immunohistochemistry with monoclonal antibodies. The reading of the findings was carried out by oral pathologists. Results: in healthy individuals, an S100A4 label was observed in Langerhans cells, while α-SMA was identified in the vascular endothelium of all samples analysed. However, in patients with GH due to orthodontics, they registered an intense staining of S100A4 in gingival fibroblasts, Langerhans cells, vascular endothelium, and areas adjacent to the rupture of blood vessel. α-SMA expression in GO was detected in the vascular endothelium and gingival fibroblasts. Conclusion: the differential immunostaining of EMT markers in gingival tissues of patients with orthodontic GH suggests an eventual role of EMT in the pathogenesis of this pathology. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
22. Alteración del colágeno en la Hipertrofia Gingival en pacientes con ortodoncia: caracterización histológica e inmunohistoquímica.
- Author
-
Simancas-Escorcia, Víctor, Lozada-Martínez, Ariana, and Díaz-Caballero, Antonio
- Published
- 2021
- Full Text
- View/download PDF
23. Individualized digitally designed surgical template for guided soft tissue surgery in cases with severe gingival enlargement: A clinical application in hereditary gingival fibromatosis.
- Author
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Sykara M, Ntovas P, Markou N, Madianos P, and Vassilopoulos S
- Subjects
- Humans, Fibromatosis, Gingival genetics, Fibromatosis, Gingival surgery, Gingival Overgrowth, Gingival Hyperplasia, Gingival Hypertrophy
- Abstract
Aim: The purpose of this study was to present the use of computer-assisted periodontal surgery utilizing a novel surgical guide for cases with severe gingival enlargement through a clinical application in a patient with hereditary gingival fibromatosis., Materials and Methods: The treatment plan included nonsurgical periodontal therapy, surgical periodontal treatment, and regular periodontal maintenance before the initiation of orthodontic treatment. Due to the increased soft tissue thickness, a surgical guide with a novel design was fabricated to facilitate the periodontal surgery since most of the patient's teeth were malpositioned and underexposed due to fibromatosis. For this purpose, the patient's intraoral scan was merged with a CBCT image in order to plan surgical excisions based on the anatomy of the teeth and the bone contour., Results: The customized surgical guide facilitated the gingivectomy by controlling not only the shape of the initial incisions but also their orientation toward the level of the cementoenamel junction, improving the efficiency of the clinical time compared with freehand surgery and assisting in the verification of the final soft tissue shape, based on the treatment plan., Conclusion: Digital technology through the superimposition of multiple data sets can assist in the diagnosis and multidisciplinary management of cases with gingival fibromatosis. The proposed design of the surgical guide can facilitate soft tissue surgery based on the digital treatment plan, leading to more predictable management of the soft tissue, especially in patients with severe gingival enlargement, as in cases with hereditary gingival fibromatosis or drug-induced gingival overgrowth.
- Published
- 2024
- Full Text
- View/download PDF
24. ELMO2 biallelic pathogenic variants in a patient with gingival hypertrophy and cherubism phenotype: Case report and molecular review.
- Author
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Perrone E, Coelho AVC, Virmond LDA, Espolaor JGA, Filho JBO, Nascimento ATBD, Matta MCD, Meira JGC, Cardoso-Júnior LM, Andrade ACM, Chaves RZT, and Acosta AX
- Abstract
Ramon syndrome (OMIM #266270) was first described in a patient with cherubism, gingival fibromatosis, epilepsy, intellectual disability, hypertrichosis, and stunted growth. In 2018, Mehawej et al. described a patient with Ramon syndrome in whom a homozygous variant in ELMO2 was identified, suggesting that this gene may be the causative for this syndrome. ELMO2 biallelic pathogenic variants were also described in patients with a primary intraosseous vascular malformation (PIVM; OMIM #606893). These patients presented gingival bleeding and cherubism phenotype. Herein, a patient with gingival hypertrophy, neurodevelopmental delay, and cherubism phenotype with a novel homozygous predicted loss-of-function (LOF) variant in the ELMO2 gene and family recurrence was reported. A surgical approach to treat gingival bleeding and mandible vascular malformation was also described. Furthermore, this study includes a comprehensive literature review of molecular data regarding the ELMO2 gene. All the variants, except one described in the ELMO2, were predicted as LOF, including our patient's variant. There is an overlapping between PIVM, also caused by LOF biallelic variants in the ELMO2 gene, and Ramon syndrome, which can suggest that they are not different entities. However, due to a limited number of cases described with molecular evaluation, it is hard to establish a genotype-phenotype correlation. Our study supports that LOF pathogenic biallelic variants in the ELMO2 gene cause a phenotype that has cherubism and gingival hypertrophy as main characteristics., (© 2024 Wiley Periodicals LLC.)
- Published
- 2024
- Full Text
- View/download PDF
25. Juvenile hyaline fibromatosis in siblings
- Author
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Valkodai Ramanathan Ravikumar, Ram Ganesh Veerappan Ramamoorthi, and Sivakumar Manisankar
- Subjects
Facial nodules ,gingival hypertrophy ,joint contracture ,juvenile hyaline fibromatosis ,juvenile systemic hyalinosis ,Pathology ,RB1-214 ,Microbiology ,QR1-502 - Abstract
Background: Juvenile Hyaline Fibromatosis is a rare autosomal recessive connective tissue disorder. Case Characteristics: Three year old girl with multiple facial nodules, gingival hypertrophy and multiple joint contractures. Her sibling, male child also had similar findings which was progressive and he died at 2 years. Outcome: Nodule biopsy showed extensively hyalinised dermis with PAS positivity. Message: Juvenile Hyaline Fibromatosis is a differential diagnosis for children presenting with multiple nodular lesions.
- Published
- 2019
- Full Text
- View/download PDF
26. Expression of type III collagen in hypertrophic gingival tissue of patients with orthodontic treatment: a pilot study.
- Author
-
SIMANCAS-ESCORCIA, VÍCTOR, LEAL-BETANCUR, JOCSAN, and DÍAZ-CABALLERO, ANTONIO
- Abstract
Copyright of Revista Facultad de Odontología Universidad de Antioquia is the property of Universidad de Antioquia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2020
- Full Text
- View/download PDF
27. Un cas marocain d'érythrophagocytose blastique et LAL T de novo sans anomalie cytogénétique.
- Author
-
Kahouli, Sophia, Zahid, Hafid, El Khorassani, Mohamed, El Kabbaj, Saâd, Benkirane, Majid, and Messaoudi, Nezha
- Abstract
Erythrophagocytosis by blast cells is due to hyperactivation of blast cells. Erythrophagocytosis is associated with T cell myeloid hemopathies (8;16). This study shows an exceptional case of erythrophagocytosis by blast cells in a patient with acute T-lymphoblastic leukemia without cytogenetic abnormalities. We here report the case of A.Z, aged 19 years presenting with febrile syndrome with dizziness and phosphenes, tumor syndrome with amygdala and gingival hypertrophy. Blood count revealed hyperleukocytosis (399.5 G/L), with aregenerative anemia (Hb: 9,3 g/dl) and thrombocytopenia (platelet count: 40 g/L). Myelogram showed 90% of blast cells (MPO-negative) with erythrophagocytosis by blast cells images. Immunophenotyping confirmed T-cell LAL. Cytogenetic analysis was normal. Erythrophagocytosis by blast cells in patients with T-cell LAL appears to be a separate entity, hence the importance of images on diagnosis, prognosis and treatment of T-cell LAL. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
28. Nonsyndromic hereditary gingival fibromatosis: Characterization of a family and review of genetic etiology.
- Author
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Resende, Elisabete Peres, Xavier, Maria Teresa, Matos, Sérgio, Antunes, Ana C., and Silva, Henriqueta Coimbra
- Subjects
GINGIVAL hyperplasia ,ETIOLOGY of diseases ,FAMILIES ,SELF-expression ,RARE diseases ,SIBLINGS - Abstract
Our aim is to describe a family with a nonsyndromic form of hereditary gingival fibromatosis (HGF) and discuss genetic characteristics of this rare disease by reviewing reported cases. A mother and three descendants were diagnosed with HGF. There was marked variable expressivity: from severe generalized gingival overgrowth in a 16-year-old boy (the proband) to minimal manifestations in the mother. The proband was submitted to gingivectomy and gingivoplasty. In younger siblings, the disease remained stable for 5 years, suggesting that clinical surveillance is a good option. The diagnosis was supported by histopathological examination. Analysis of this family and literature-reported cases supports that HGF most frequently shows an autosomal dominant inheritance with high penetrance and variable expressivity. Neomutations and gonadal mosaicism do not seem to be a rare event. Although five loci have been mapped by linkage analysis, only two genes, SOS1 and REST, were identified in four families. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
29. Gingival Hypertrophy in a Child with Hyaline Fibromatosis Syndrome.
- Author
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Knežević, Predrag, Tarle, Marko, Fratrić, Lucija Ida, Tarle, Antonia, Knežević-Krajina, Hana, and Macan, Darko
- Subjects
GENETIC mutation ,GINGIVAL hyperplasia ,HYPERTROPHY ,MEMBRANE proteins ,GENETIC disorders ,EXTRACELLULAR space - Abstract
Copyright of Acta Stomatologica Croatica is the property of Acta Stomatologica Croatica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2020
- Full Text
- View/download PDF
30. Fibromatosis hialina juvenil: una rara enfermedad con implicaciones orales.
- Author
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Minutti, Gustavo, Manuel Aparicio-Rodríguez, Juan, Alberto Hachity-Ortega, José, and Huitzil Muñoz, Enrique
- Abstract
Copyright of Revista de la Academia Mexicana de Odontología Pediátrica (2594-1798) is the property of Academia Mexicana de Odontologia Pediatrica, A. C. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2020
31. Diode Laser in Gingival Enlargement Related to Orthodontics
- Author
-
Dr. Tony Ngan-fat TO/ Master student
- Published
- 2011
32. Sturge-Weber Syndrome: A Report of a Rare Case.
- Author
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Sherwani OA, Patra PC, Ahmad SA, and Hasan S
- Abstract
Sturge-Weber Syndrome (SWS) is a rare congenital developmental disorder that arises from the abnormal persistence of the embryonic vascular plexus. The syndrome encompasses hamartomatous malformations that can impact the skin, eyes, and nervous system. The broad array of clinical manifestations and potentially life-threatening complications underscores the crucial and imperative need for an accurate diagnosis. An effective treatment strategy for SWS patients involves a multidisciplinary approach. Dental procedures in these individuals pose challenges due to the potential risk for substantial bleeding during both intra- and postoperative phases. This article aims to document a rare case of Sturge Weber Syndrome in a 21-year-old female patient who presented with seizures, unilateral facial port wine stains, gingival hyperplasia, and intracranial calcifications., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2023, Sherwani et al.)
- Published
- 2023
- Full Text
- View/download PDF
33. Cowden syndrome: new clinical features in a large family; joint hyperextensibility, dental abnormalities and gingival enlargement
- Author
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Tricia Heaton, Kai Ren Ong, Ataf Sabir, and Gabriella Parry
- Subjects
Male ,medicine.medical_specialty ,Genotype ,Physical examination ,Case Report ,03 medical and health sciences ,0302 clinical medicine ,Intellectual Disability ,Intellectual disability ,medicine ,PTEN ,Humans ,Family history ,Gingival Hypertrophy ,medicine.diagnostic_test ,biology ,business.industry ,Macrocephaly ,PTEN Phosphohydrolase ,Cancer ,030206 dentistry ,General Medicine ,Cowden syndrome ,medicine.disease ,Dermatology ,Gingival enlargement ,Phenotype ,030220 oncology & carcinogenesis ,Child, Preschool ,biology.protein ,medicine.symptom ,business ,Hamartoma Syndrome, Multiple - Abstract
A 4-year-old boy presented with his mother to genetics in the 1980s, with a family history (FH) of macrocephaly and intellectual disability (ID). He remained undiagnosed until his mother developed multiple cancers and was diagnosed with Cowden syndrome (CS) in 2017, a rare, multisystem cancer predisposition syndrome. CS was then confirmed in multiple family members. Clinical examination revealed potentially novel features; gingival enlargement, dental abnormalities and joint hyperextensibility. These features could contribute to revised PTEN hamartoma tumour syndrome, National Comprehensive Cancer Network, minor diagnostic criteria. The paediatric CS phenotype is still emerging and features expressed in this family during childhood could potentially aid paediatric diagnosis. This case reminds clinicians to seek genetic input for PTEN testing when macrocephaly is identified alongside, a personal or FH of ID, early-onset tumours (especially breast, bowel or thyroid) or multiple tumours. Thus detailed FH is pivotal to earlier CS diagnosis and improved patient outcomes.
- Published
- 2023
34. Gingival hypertrophy in a kidney transplant recipient
- Author
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Abderrahmane Mabrouk, Yanis Tamzali, Benoit Barrou, and Jérôme Tourret
- Subjects
Graft Rejection ,Transplantation ,Calcineurin Inhibitors ,Graft Survival ,Humans ,Immunology and Allergy ,Pharmacology (medical) ,Kidney Transplantation ,Immunosuppressive Agents ,Tacrolimus ,Transplant Recipients ,Gingival Hypertrophy - Published
- 2022
35. Hyaline fibromatosis syndrome: cutaneous manifestations
- Author
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Silvio Alencar Marques, Hamilton Ometto Stolf, Juliana Ocanha Polizel, Tânia Munhoz, Marcela Calixto Brandão, and Mariangela Esther Alencar Marques
- Subjects
Fibroma ,Gingival hypertrophy ,Skin: Skin manifestations ,Mutation ,Dermatology ,RL1-803 - Abstract
Abstract Hyaline fibromatosis syndrome is the current name for clinical manifestations of diseases previously known as “infantile systemic hyalinosis” and “juvenile hyaline fibromatosis”. The authors report representative clinical cases of each one of the above subtypes with emphasis on cutaneous manifestations and difficulties for early diagnosis in this syndrome, essentially of multidisciplinary approach.
- Published
- 2016
- Full Text
- View/download PDF
36. Oral Microflora, in Cases with Gingival Hypertrophy Caused by Fixed Orthodontic Appliances
- Author
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Saimir Heta, Enxhi Gjumsi, Ilma Robo, and Vera Ostreni
- Subjects
Laboratory examination ,Gingival Hypertrophy ,business.industry ,Oral microbiology ,Oral Microflora ,Dentistry ,Medicine ,Topical treatment ,General Medicine ,Gingival sulcus ,business ,Fixed orthodontic appliance ,Oral cavity - Abstract
Placement of orthodontic apparatus in oral cavity, according to the literature, should influence the alteration of oral flora, especially the subgingival one. The purpose of the study is to evaluate the subgingival flora of patients with fixed orthodontic appliances, regardless of placement time. At 3 cases of patients with fixed orthodontic appliances, a bacterial sample of gingival sulcus was taken for laboratory examination. Patients were clinically evaluated for the presence or tendency, of having gingival hypertrophy. Results from the 3 cases included in the study: 1 of them was Streptococcus Anginosus positive, Doxycyline-sensitive. The tendency for gingival hypertrophy was maximal 3 to 1.5% respectively in each patient. At the patient with different oral flora, was applied daily topical treatment with tetracycline, placed in the gingival sulcus. Alteration of the oral flora with the placement of fixed orthodontic appliances is not a fully verifiable fact, as it indicates the patient’s follow-up, at the time of placement of the apparatus and until removal of appliance after orthodontic treatment, depending on the 2–3-year period of treatment. The tendency for gingival hypertrophy is apparently high, versus the presence of fixed orthodontic appliance.
- Published
- 2021
37. Test Yourself-Question: Multiple facial skin lesions associated with gingival hypertrophy in a pair of siblings
- Author
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Valérie Segers, Nour Marroun, Grammatina Boitsios, and Diane Franck
- Subjects
Male ,congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Pédiatrie ,First year of life ,Asymptomatic ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Imagerie médicale, radiologie, tomographie ,Gingival Hypertrophy ,Scalp ,business.industry ,Siblings ,Soft tissue ,Toes ,Dermatology ,body regions ,Facial skin ,medicine.anatomical_structure ,Face ,Orthopedic surgery ,medicine.symptom ,business - Abstract
Two brothers, completely asymptomatic until their first year of life, started to complain from gingival hypertrophy, progressive development of painful soft tissue masses on the fingers and toes, on the face and on the scalp. There were no neurological symptoms or mental delay for both brothers.
- Published
- 2021
38. Amlodipine-induced reversible gum hypertrophy
- Author
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Gutch Manish, Shakya Shobhit, Kumar Sukriti, Annesh Bhattacharjee, and Rao Somendra Singh
- Subjects
Amlodipine ,calcium channel blockers ,gingival hypertrophy ,Pharmacy and materia medica ,RS1-441 - Abstract
Gingival hypertrophy is a common manifestation of any pathology affecting gingival and periodontal regions. It commonly follows inflammatory disorders, Vitamin C deficiency, leukemia and due to drugs such as anticonvulsants, immunosuppressants, and calcium channel blockers. Amlodipine is a third generation dihydropyridine derived calcium channel blocker commonly used to treat hypertension. Here, we describe the case of a 45-year-old hypertensive woman who was on amlodipine for 1 year and subsequently developed one of its rarest adverse effects, i.e., gingival hypertrophy.
- Published
- 2016
- Full Text
- View/download PDF
39. Gingival Hypertrophy
- Author
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van der Wal, Jacqueline E., van Krieken, J. H. J. M., Series Editor, and Slootweg, Pieter J., editor
- Published
- 2016
- Full Text
- View/download PDF
40. Hereditary gingival fibromatosis in children: a systematic review of the literature
- Author
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Aikaterini-Elisavet Doufexi, Ioannis A. Ziogas, Dimitrios Giannis, and Eirini Boutiou
- Subjects
medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Gingiva ,Cochrane Library ,Gingivectomy ,03 medical and health sciences ,0302 clinical medicine ,Epidemiology ,medicine ,Humans ,Family history ,Child ,General Dentistry ,Fibromatosis, Gingival ,Gingival Overgrowth ,business.industry ,030206 dentistry ,medicine.disease ,Dermatology ,Hereditary gingival fibromatosis ,Gingival enlargement ,Systematic review ,Gingival Hypertrophy ,030220 oncology & carcinogenesis ,business - Abstract
Hereditary gingival fibromatosis (HGF) is an uncommon, inherited condition with slow and progressive fibrous hyperplasia of the gingiva. Due to its association with mastication, speech, and occlusion problems, early diagnosis is important. We sought to summarize the available data regarding the epidemiology, clinical characteristics, and outcomes of children with HGF (< 18 years). A systematic literature review of the MEDLINE and Cochrane Library databases was conducted with respect to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement (end-of-search date: March 1, 2019). A total of 99 articles reporting on 146 patients were included. The mean age was 10.82 ± 3.93 years, and generalized gingival enlargement was seen in 97.16% (95% CI 92.69 to 99.14). Jaw, gingival, and teeth abnormalities; poor oral hygiene; eating; or speech difficulties were typical HGF-induced, while 60.90% had extraoral manifestations (95% CI 52.41 to 68.78). The disease was most commonly inherited in an autosomal dominant manner (88.41%, 95% CI 78.5 to 94.26), and about one-third of the patients had syndromic HGF (33.85%, 95% CI 23.50 to 46.00). Gingivectomy was performed in the majority of cases (91.15%, 95% CI 84.31 to 95.29), and recurrence was seen in 33.85% (95% CI 23.50 to 46.00). HGF should be suspected in children with nodularity and gingival fibrosis, teeth abnormalities, or jaw distortion. Family history can help to establish the diagnosis. More cases should focus on longer-term follow-up after gingivectomy as disease recurrence is not uncommon.
- Published
- 2020
41. CYTOLOGY AND MOLECULAR MECHANISMS OF DRUG-INDUCED GINGIVAL HYPERTROPHY: A REWIEW.
- Author
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LUCIANI, F., PAOLANTONIO, G., CALABRESE, C., and CALABRESE, L.
- Subjects
- *
CYTOLOGY , *HYPERTROPHY , *ORAL hygiene - Abstract
Introduction. Gingival hypertrophy is a frequent condition associated to the increased number of patients taking some categories of drugs. The goal of this work is to emphasize the importance of diagnosis to set a proper therapy. Material and methods. The plaque accumulation in patients having a poor oral hygiene damages the periodontium and requires the application of strict professional and home hygiene protocols. Results and conclusion. The drug-induced gingival proliferation knowledge is essential in order to succeed in working with the internist and in planning a precise therapy, without interfering with the metabolism of drugs, often necessary and irreplaceable for patients' health. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
42. Cyclosporine-Induced Gingival Hyperplasia in a Patient With Lichen Planopilaris: Misfortunes Never Come Singly!
- Author
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Zisis V, Andreadis D, Karpouzi R, Karadagli T, and Poulopoulos A
- Abstract
Cyclosporine A constitutes an immunosuppressive medication administered against various autoimmune and autoinflammatory disorders as well as against graft versus host disease. Its most well-known oral adverse effect is gingival hyperplasia. The aim of this study is to report a persistent case of a patient with lichen planopilaris with alopecia treated with cyclosporine leading to the manifestation of gingival hypertrophy. A female patient aged 38 years old was referred to the Department of Oral Medicine/Pathology, Dental School, Aristotle University of Thessaloniki, Greece complaining about gum bleeding, halitosis, and a persistent gingival enlargement, which appeared two months ago. According to her medical history, lichen planopilaris was diagnosed six months ago and was initially treated for 40 days with methylprednisolone 16 mg twice per day without improvement, and was replaced by cyclosporine A 200 mg per day. The clinical oral examination revealed gingival enlargement at areas #34-43, 22-23, and 25-27 without any lesion of lichen planus. The level of oral hygiene was satisfactory, with a limited amount of tartar and plaque. Bleeding on probing was also noticed, and pseudopockets of 5 mm were observed. The serum levels of cyclosporine were 473,60 μg/L, with a normal range, regarding repercussions in the oral cavity, up to 200 μg/L. A decrease of cyclosporine dosage to 150 mg was performed. After 15 days, the clinical appearance significantly improved, and a biopsy was done. The microscopic findings showed mild ulceration and inflammatory infiltrates, together with the abundant presence of collagen stroma, without any sign of malignancy. According to the literature, the high dosage of cyclosporine, its relevant high serum levels, and the presence of plaque were responsible for the manifestation of gingival hypertrophy., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2023, Zisis et al.)
- Published
- 2023
- Full Text
- View/download PDF
43. Idiopathic gingival fibromatosis with ocular dystrophy rutherfurd's syndrome? (A case report)
- Author
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Jawade, Rashmi B. and Doiphode, S.S
- Published
- 2011
44. Nonsyndromic hereditary gingival fibromatosis: Characterization of a family and review of genetic etiology
- Author
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Henriqueta Coimbra Silva, Elisabete Peres Resende, Ana C. Antunes, Maria Teresa Xavier, and Sérgio Matos
- Subjects
Male ,Proband ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Germline mosaicism ,Disease ,Gingivectomy ,03 medical and health sciences ,0302 clinical medicine ,Genetic linkage ,medicine ,Humans ,030212 general & internal medicine ,General Dentistry ,Fibromatosis, Gingival ,Gingival Overgrowth ,business.industry ,030206 dentistry ,medicine.disease ,Dermatology ,Hereditary gingival fibromatosis ,Gingival Hypertrophy ,business ,Rare disease - Abstract
Our aim is to describe a family with a nonsyndromic form of hereditary gingival fibromatosis (HGF) and discuss genetic characteristics of this rare disease by reviewing reported cases. A mother and three descendants were diagnosed with HGF. There was marked variable expressivity: from severe generalized gingival overgrowth in a 16-year-old boy (the proband) to minimal manifestations in the mother. The proband was submitted to gingivectomy and gingivoplasty. In younger siblings, the disease remained stable for 5 years, suggesting that clinical surveillance is a good option. The diagnosis was supported by histopathological examination. Analysis of this family and literature-reported cases supports that HGF most frequently shows an autosomal dominant inheritance with high penetrance and variable expressivity. Neomutations and gonadal mosaicism do not seem to be a rare event. Although five loci have been mapped by linkage analysis, only two genes, SOS1 and REST, were identified in four families.
- Published
- 2020
45. Escorbuto en el siglo XXI
- Author
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Mariela Alonso, Miguel Allevato, Juliana Martínez del Sel, Dante Chinchilla, and Alejandro Oxilia
- Subjects
Vitamin ,chemistry.chemical_classification ,Vitamin C ,business.industry ,Physiology ,Scurvy ,medicine.disease ,Ascorbic acid ,chemistry.chemical_compound ,Gingivitis ,Enzyme ,chemistry ,Gingival Hypertrophy ,Follicular phase ,medicine ,medicine.symptom ,business - Abstract
El escorbuto es una enfermedad causada por la deficiencia de vitamina C o ácido ascórbico. Sus manifestaciones clínicas son variadas debido a que esa vitamina es un cofactor de enzimas que intervienen en numerosos procesos, como la síntesis de colágeno y la absorción de diferentes nutrientes. La expresión cutánea característica son las petequias foliculares con pelos en cuello de cisne y en tirabuzón. El compromiso mucoso se manifiesta como hipertrofia y hemorragia gingival, gingivitis y pérdida de piezas dentarias. El diagnóstico es clínico y puede confirmarse mediante la determinación de la vitamina C plasmática o leucocitaria. El tratamiento se basa en el aporte suplementario de esa vitamina. Se presenta el caso de un paciente de 32 años con escorbuto debido a una dieta casi exclusivamente a base de harinas y carente de frutas y verduras.
- Published
- 2020
46. Juvenile Hyaline Fibromatosis Management With a Diode Laser: A Rare Case Report
- Author
-
Mehrdad Amirmoini, Neda Hakimiha, Farzad Fazilat, Katayoun Am Kalhori, Reza Fekrazad, and Maryam Nikhalat Jahromi
- Subjects
medicine.medical_specialty ,Urology ,Case Report ,Signs and symptoms ,Dermatology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Rare case ,medicine ,Dentistry (miscellaneous) ,Orthopedics and Sports Medicine ,030223 otorhinolaryngology ,Muscle contracture ,business.industry ,Cheek ,medicine.disease ,Penetrance ,Antibiotic prescription ,Surgery ,medicine.anatomical_structure ,Nephrology ,Gingival Hypertrophy ,Juvenile hyaline fibromatosis ,business - Abstract
Juvenile hyaline fibromatosis (JHF) is an unknown hereditary disorder with variable penetrance. The characterizations of this disease consist of different signs and symptoms such as multiple tumorous (tumor-like) muco-cutaneous proliferation, gingival hypertrophy, perianal lesions, articular contractures, and osteolytic lesions. A 3-year-old girl with numerous painless nodular masses on her gingival, ear and anal areas is presented in this case report. Based on characteristic histological features, the diagnosis of JHF was made. The patient underwent surgery following general anesthesia and the above areas were surgically operated with appropriate laser parameters, and the patient was able to eat and wash away after a day and was discharged with an antibiotic prescription after one day in the hospital and returned to normal after a week. The recurrence occurred in other areas a year later, especially in the cheek, the ears and the anal area. Therefore, this rare case is presented with recurrence.
- Published
- 2020
47. Gingival Hypertrophy in a Child with Hyaline Fibromatosis Syndrome
- Author
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Antonia Tarle, Predrag Knežević, Hana Knežević-Krajina, Lucija Ida Fratrić, Darko Macan, and Marko Tarle
- Subjects
Pathology ,medicine.medical_specialty ,medicine.medical_treatment ,Case Report ,Disease ,ANTXR2 gene ,extracellular matrix ,gingival hypertrophy ,gingivectomy ,systemic hyalinosis ,Gingivectomy ,Extracellular matrix ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,Enteropathy ,Joint Contracture ,Systemic Hyalinosis ,General Dentistry ,Hyaline ,Gingival Hypertrophy ,business.industry ,Extracellular Matrix ,Genetic disorder ,medicine.disease ,lcsh:RK1-715 ,lcsh:Dentistry ,business ,030217 neurology & neurosurgery - Abstract
Hyaline fibromatosis syndrome (HFS) is a rare autosomal recessive genetic disorder characterized by accumulation of hyalinized fibrous tissue with cutaneous, mucosal, osteoarticular, and systemic involvement. The condition is caused by a mutation of ANTXR2 gene that results in a faulty synthesis of a transmembrane protein which leads up to excessive deposition of hyaline material in extracellular space. The first signs may be present at birth or appear during infancy, and joint stiffness is the first, most common, symptom. Other manifestations include joint contractures, hyperpigmented macules over bony prominences of the joints, and gingival hypertrophy. The symptom that raises suspicion of HFS is present later, along with subcutaneous growths. The progression of the disease includes enteropathy with extensive protein loss, chronic diarrhea and frequent infections. We present a case of a five-year- old girl with severe gingival hypertrophy that caused difficulties in eating and speaking. To the best of our knowledge, this is also the first patient in Croatia with a confirmed ANTXR2 gene mutation described in the literature.
- Published
- 2020
48. Healing without Surgery: A Case of Supernumerary Tooth
- Author
-
Germano Orrù, Luca Viganò, Giovanna Mosaico, and Cinzia Casu
- Subjects
medicine.medical_specialty ,Supernumerary tooth ,business.industry ,030206 dentistry ,030226 pharmacology & pharmacy ,Surgery ,stomatognathic diseases ,03 medical and health sciences ,0302 clinical medicine ,Gingival Hypertrophy ,medicine ,Soft tissue lesion ,business ,General Dentistry ,Pulp necrosis - Abstract
Background: Supernumerary teeth are present in 0,2-3% of the population. Multiple supernumeraries are often associated with syndromes such as cleidocranial dysplasia and Gardner's syndrome. They often hinder the permanent eruption’s teeth, causing cavities, periodontal lesions, pulp necrosis, and in some cases follicular cysts. Reactive lesions such as fibroma, local fibrous hyperplasia, pyogenic granuloma, and peripheral ossifying fibroma are frequent gingival lesions. Materials and Methods: We reported a case of a 9 years old patient with the missed eruption of a permanent element caused by a supernumerary tooth, associated with an exophytic palatine lesion. The deciduous incisor was still present and the supernumerary included. It was decided to proceed with the extraction of the deciduous and to wait for scheduling checks every two months. After a few months, the conoid shape supernumerary tooth erupted in the maxillary arch, so a fixed orthodontic therapy was performed to create the space for the central incisor’s eruption. Results: After a few months, the tooth began to erupt in the arch thanks to orthodontic traction. The patient was instructed to correct and specific oral hygiene maneuvers to lower the plaque index and try to reduce gingival hypertrophy. Conclusion: Supernumerary teeth often hinder the eruption and development of the related permanent tooth causing localized periodontal problems. Corrective fixed orthodontics requires more strict oral hygiene to avoid periodontal complications.
- Published
- 2019
49. Cyclosporin — longterm treatment
- Author
-
Briggs, J. Douglas, Touraine, J. L., editor, Traeger, J., editor, Bétuel, H., editor, Dubernard, J. M., editor, Revillard, J. P., editor, and Dupuy, C., editor
- Published
- 1997
- Full Text
- View/download PDF
50. Otorhinolaryngeal
- Author
-
Goltra, Peter S. and Goltra, Peter S.
- Published
- 1997
- Full Text
- View/download PDF
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