Search

Your search keyword '"Giné-Vázquez, Iago"' showing total 38 results
Start Over Author "Giné-Vázquez, Iago"
38 results on '"Giné-Vázquez, Iago"'

1. Adolescent transport and unintentional injuries: a systematic analysis using the Global Burden of Disease Study 2019

Author

Peden, Amy E, Cullen, Patricia, Francis, Kate Louise, Moeller, Holger, Peden, Margaret M, Ye, Pengpeng, Tian, Maoyi, Zou, Zhiyong, Sawyer, Susan M, Aali, Amirali, Abbasi-Kangevari, Zeinab, Abbasi-Kangevari, Mohsen, Abdelmasseh, Michael, Abdoun, Meriem, Abd-Rabu, Rami, Abdulah, Deldar Morad, Abebe, Getachew, Abebe, Ayele Mamo, Abedi, Aidin, Abidi, Hassan, Aboagye, Richard Gyan, Abubaker Ali, Hiwa, Abu-Gharbieh, Eman, Adane, Denberu Eshetie, Adane, Tigist Demssew, Addo, Isaac Yeboah, Adewole, Ololade Grace, Adhikari, Sangeet, Adnan, Mohammad, Adnani, Qorinah Estiningtyas Sakilah, Afolabi, Aanuoluwapo Adeyimika Bachelor, Afzal, Saira, Afzal, Muhammad Sohail, Aghdam, Zahra Babaei, Ahinkorah, Bright Opoku, Ahmad, Araz Ramazan, Ahmad, Tauseef, Ahmad, Sajjad, Ahmadi, Ali, Ahmed, Haroon, Ahmed, Muktar Beshir, Ahmed, Ali, Ahmed, Ayman, Ahmed, Jivan Qasim, Ahmed Rashid, Tarik, Aithala, Janardhana P, Aji, Budi, Akhlaghdoust, Meisam, Alahdab, Fares, Alanezi, Fahad Mashhour, Alemayehu, Astawus, Al Hamad, Hanadi, Ali, Syed Shujait, Ali, Liaqat, Alimohamadi, Yousef, Alipour, Vahid, Aljunid, Syed Mohamed, Almidani, Louay, Almustanyir, Sami, Altirkawi, Khalid A, Alvis-Zakzuk, Nelson J, Ameyaw, Edward Kwabena, Amin, Tarek Tawfik, Amir-Behghadami, Mehrdad, Amiri, Sohrab, Amiri, Hoda, Anagaw, Tadele Fentabil, Andrei, Tudorel, Andrei, Catalina Liliana, Anvari, Davood, Anwar, Sumadi Lukman, Anyasodor, Anayochukwu Edward, Arabloo, Jalal, Arab-Zozani, Morteza, Arja, Asrat, Arulappan, Judie, Arumugam, Ashokan, Aryannejad, Armin, Asgary, Saeed, Ashraf, Tahira, Athari, Seyyed Shamsadin, Atreya, Alok, Attia, Sameh, Aujayeb, Avinash, Awedew, Atalel Fentahun, Azadnajafabad, Sina, Azangou-Khyavy, Mohammadreza, Azari, Samad, Azari Jafari, Amirhossein, Azizi, Hosein, Azzam, Ahmed Y, Badiye, Ashish D, Baghcheghi, Nayereh, Bagherieh, Sara, Baig, Atif Amin, Bakkannavar, Shankar M, Balta, Asaminew Birhanu, Banach, Maciej, Banik, Palash Chandra, Bansal, Hansi, Bardhan, Mainak, Barone-Adesi, Francesco, Barrow, Amadou, Bashiri, Azadeh, Baskaran, Pritish, Basu, Saurav, Bayileyegn, Nebiyou Simegnew, Bekel, Abebe Ayalew, Bekele, Alehegn Bekele, Bendak, Salaheddine, Bensenor, Isabela M, Berhie, Alemshet Yirga, Bhagat, Devidas S, Bhagavathula, Akshaya Srikanth, Bhardwaj, Pankaj, Bhardwaj, Nikha, Bhaskar, Sonu, Bhat, Ajay Nagesh, Bhattacharyya, Krittika, Bhutta, Zulfiqar A, Bibi, Sadia, Bintoro, Bagas Suryo, Bitaraf, Saeid, Bodicha, Belay Boda Abule, Boloor, Archith, Bouaoud, Souad, Brown, Julie, Burkart, Katrin, Butt, Nadeem Shafique, Butt, Muhammad Hammad, Cámera, Luis Alberto, Campuzano Rincon, Julio Cesar, Cao, Chao, Carvalho, Andre F, Carvalho, Márcia, Chakraborty, Promit Ananyo, Chandrasekar, Eeshwar K, Chang, Jung-Chen, Charalampous, Periklis, Charan, Jaykaran, Chattu, Vijay Kumar, Chekole, Bitew Mekonnen, Chitheer, Abdulaal, Cho, Daniel Youngwhan, Chopra, Hitesh, Christopher, Devasahayam J, Chukwu, Isaac Sunday, Cruz-Martins, Natália, Dadras, Omid, Dahlawi, Saad M A, Dai, Xiaochen, Damiani, Giovanni, Darmstadt, Gary L, Darvishi Cheshmeh Soltani, Reza, Darwesh, Aso Mohammad, Das, Saswati, Dastiridou, Anna, Debela, Sisay Abebe, Dehghan, Amin, Demeke, Getnet Makasha, Demetriades, Andreas K, Demissie, Solomon, Dessalegn, Fikadu Nugusu, Desta, Abebaw Alemayehu, Dianatinasab, Mostafa, Diao, Nancy, Dias da Silva, Diana, Diaz, Daniel, Digesa, Lankamo Ena, Diress, Mengistie, Djalalinia, Shirin, Doan, Linh Phuong, Dodangeh, Milad, Doku, Paul Narh, Dongarwar, Deepa, Dsouza, Haneil Larson, Eini, Ebrahim, Ekholuenetale, Michael, Ekundayo, Temitope Cyrus, Elagali, Ahmed Elabbas Mustafa, Elbahnasawy, Mostafa Ahmed, Elhabashy, Hala Rashad, Elhadi, Muhammed, El Sayed Zaki, Maysaa, Enyew, Daniel Berhanie, Erkhembayar, Ryenchindorj, Eskandarieh, Sharareh, Etaee, Farshid, Fagbamigbe, Adeniyi Francis, Faris, Pawan Sirwan, Farmany, Abbas, Faro, Andre, Farzadfar, Farshad, Fatehizadeh, Ali, Fereshtehnejad, Seyed-Mohammad, Feroze, Abdullah Hamid, Fetensa, Getahun, Feyisa, Bikila Regassa, Filip, Irina, Fischer, Florian, Foroutan, Behzad, Foroutan, Masoud, Fowobaje, Kayode Raphael, Franklin, Richard Charles, Fukumoto, Takeshi, Gaal, Peter Andras, Gadanya, Muktar A, Galali, Yaseen, Galehdar, Nasrin, Ganesan, Balasankar, Garg, Tushar, Gebrehiwot, Mesfin Gebrehiwot Damtew, Gebremariam, Yosef Haile, Gela, Yibeltal Yismaw, Gerema, Urge, Ghafourifard, Mansour, Ghamari, Seyyed-Hadi, Ghanbari, Reza, Ghasemi Nour, Mohammad, Gholamalizadeh, Maryam, Gholami, Ali, Gholamrezanezhad, Ali, Ghozy, Sherief, Gilani, Syed Amir, Gill, Tiffany K, Giné-Vázquez, Iago, Girma, Zeleke Abate, Glasbey, James C, Glozah, Franklin N, Golechha, Mahaveer, Goleij, Pouya, Grivna, Michal, Guadie, Habtamu Alganeh, Gunawardane, Damitha Asanga, Guo, Yuming, Gupta, Veer Bala, Gupta, Sapna, Gupta, Bhawna, Gupta, Vivek Kumar, Haj-Mirzaian, Arvin, Halwani, Rabih, Hamadeh, Randah R, Hameed, Sajid, Hanif, Asif, Hargono, Arief, Harlianto, Netanja I, Harorani, Mehdi, Hasaballah, Ahmed I, Hasan, S M Mahmudul, Hassan, Amr, Hassanipour, Soheil, Hassankhani, Hadi, Havmoeller, Rasmus J, Hay, Simon I, Heidari, Mohammad, Hendrie, Delia, Heyi, Demisu Zenbaba, Hiraike, Yuta, Holla, Ramesh, Horita, Nobuyuki, Hossain, Sheikh Jamal, Hossain, Mohammad Bellal Hossain, Hosseini Shabanan, Sedighe, Hosseinzadeh, Mehdi, Hostiuc, Sorin, Hoveidaei, Amir Human, Hsiao, Alexander Kevin, Hussain, Salman, Hussein, Amal, Ibitoye, Segun Emmanuel, Ilesanmi, Olayinka Stephen, Ilic, Irena M, Ilic, Milena D, Immurana, Mustapha, Inbaraj, Leeberk Raja, Islam, Sheikh Mohammed Shariful, Islam, Rakibul M, Islam, Mohammad Mainul, Ismail, Nahlah Elkudssiah, J, Linda Merin, Jahrami, Haitham, Jakovljevic, Mihajlo, Janodia, Manthan Dilipkumar, Javaheri, Tahereh, Jayapal, Sathish Kumar, Jayarajah, Umesh Umesh, Jayaraman, Sudha, Jeganathan, Jayakumar, Jemal, Bedru, Jha, Ravi Prakash, Jonas, Jost B, Joo, Tamas, Joseph, Nitin, Jozwiak, Jacek Jerzy, Jürisson, Mikk, Kabir, Ali, Kadashetti, Vidya, Kadir, Dler Hussein, Kalankesh, Laleh R, Kalankesh, Leila R, Kalhor, Rohollah, Kamal, Vineet Kumar, Kamath, Rajesh, Kandel, Himal, Kantar, Rami S, Kapoor, Neeti, Karami, Hassan, Karaye, Ibraheem M, Karkhah, Samad, Katoto, Patrick DMC, Kauppila, Joonas H, Kayode, Gbenga A, Keikavoosi-Arani, Leila, Keskin, Cumali, Khader, Yousef Saleh, Khajuria, Himanshu, Khammarnia, Mohammad, Khan, Ejaz Ahmad, Khan, Md Nuruzzaman, Khan, Maseer, Khan, Yusra H, Khan, Imteyaz A, Khan, Abbas, Khan, Moien AB, Khanali, Javad, Khatatbeh, Moawiah Mohammad, Khayat Kashani, Hamid Reza, Khubchandani, Jagdish, Kifle, Zemene Demelash, Kim, Jihee, Kim, Yun Jin, Kisa, Sezer, Kisa, Adnan, Kneib, Cameron J, Kompani, Farzad, Koohestani, Hamid Reza, Koul, Parvaiz A, Koulmane Laxminarayana, Sindhura Lakshmi, Koyanagi, Ai, Krishan, Kewal, Krishnamoorthy, Vijay, Kucuk Bicer, Burcu, Kumar, Nithin, Kumar, Naveen, Kumar, Narinder, Kumar, Manasi, Kurmi, Om P, Laflamme, Lucie, Lám, Judit, Landires, Iván, Larijani, Bagher, Lasrado, Savita, Lauriola, Paolo, La Vecchia, Carlo, Lee, Shaun Wen Huey, Lee, Yo Han, Lee, Sang-woong, Lee, Wei-Chen, Legesse, Samson Mideksa, Li, Shanshan, Lim, Stephen S, Lorenzovici, László, Luke, Amana Ogeto, Madadizadeh, Farzan, Madureira-Carvalho, Áurea M, Magdy Abd El Razek, Muhammed, Mahjoub, Soleiman, Mahmoodpoor, Ata, Mahmoudi, Razzagh, Mahmoudimanesh, Marzieh, Majeed, Azeem, Makki, Alaa, Malakan Rad, Elaheh, Malekpour, Mohammad-Reza, Malik, Ahmad Azam, Mallhi, Tauqeer Hussain, Malta, Deborah Carvalho, Mansouri, Borhan, Mansournia, Mohammad Ali, Mathews, Elezebeth, Maulud, Sazan Qadir, Mazingi, Dennis, Mehrabi Nasab, Entezar, Mendoza-Cano, Oliver, Menezes, Ritesh G, Mengistu, Dechasa Adare, Mentis, Alexios-Fotios A, Meretoja, Atte, Mesregah, Mohamed Kamal, Mestrovic, Tomislav, Micheletti Gomide Nogueira de Sá, Ana Carolina, Miller, Ted R, Mirghaderi, Seyed Peyman, Mirica, Andreea, Mirmoeeni, Seyyedmohammadsadeq, Mirrakhimov, Erkin M, Mirza, Moonis, Misra, Sanjeev, Mithra, Prasanna, Mittal, Chaitanya, Moberg, Madeline E, Mohammadi, Mokhtar, Mohammadi, Soheil, Mohammadi, Esmaeil, Mohammadpourhodki, Reza, Mohammed, Shafiu, Mohammed, Teroj Abdulrahman, Mohseni, Mohammad, Mokdad, Ali H, Momtazmanesh, Sara, Monasta, Lorenzo, Moni, Mohammad Ali, Moreira, Rafael Silveira, Morrison, Shane Douglas, Mostafavi, Ebrahim, Mousavi Isfahani, Haleh, Mubarik, Sumaira, Muccioli, Lorenzo, Mukherjee, Soumyadeep, Mulita, Francesk, Mustafa, Ghulam, Nagarajan, Ahamarshan Jayaraman, Naimzada, Mukhammad David, Nangia, Vinay, Nassereldine, Hasan, Natto, Zuhair S, Nayak, Biswa Prakash, Negoi, Ionut, Nejadghaderi, Seyed Aria, Nepal, Samata, Neupane Kandel, Sandhya, Noroozi, Nafise, Nuñez-Samudio, Virginia, Nzoputam, Ogochukwu Janet, Nzoputam, Chimezie Igwegbe, Ochir, Chimedsuren, Odhiambo, Julius Nyerere, Odukoya, Oluwakemi Ololade, Okati-Aliabad, Hassan, Okonji, Osaretin Christabel, Olagunju, Andrew T, Omar Bali, Ahmed, Omer, Emad, Otoiu, Adrian, Otstavnov, Stanislav S, Otstavnov, Nikita, Oumer, Bilcha, Owolabi, Mayowa O, P A, Mahesh, Padron-Monedero, Alicia, Padubidri, Jagadish Rao, Pahlevan Fallahy, Mohammad Taha, Palicz, Tamás, Panda-Jonas, Songhomitra, Pandi-Perumal, Seithikurippu R, Pardhan, Shahina, Park, Eun-Kee, Patel, Sangram Kishor, Pathan, Aslam Ramjan, Pati, Siddhartha, Paudel, Uttam, Pawar, Shrikant, Pedersini, Paolo, Peres, Mario F P, Petcu, Ionela-Roxana, Phillips, Michael R, Pillay, Julian David, Piracha, Zahra Zahid, Poursadeqiyan, Mohsen, Pourtaheri, Naeimeh, Qattea, Ibrahim, Radfar, Amir, Rafiee, Ata, Raghav, Pankaja Raghav, Rahim, Fakher, Rahman, Muhammad Aziz, Rahman, Firman Suryadi, Rahman, Mosiur, Rahmani, Amir Masoud, Rahmani, Shayan, Raj Moolambally, Sheetal, Ramazanu, Sheena, Ramezanzadeh, Kiana, Rana, Juwel, Rao, Chythra R, Rao, Sowmya J, Rashedi, Vahid, Rashidi, Mohammad-Mahdi, Rastogi, Prateek, Rasul, Azad, Rawaf, Salman, Rawaf, David Laith, Rawal, Lal, Rawassizadeh, Reza, Rezaei, Negar, Rezaei, Nazila, Rezaeian, Mohsen, Rezapour, Aziz, Riad, Abanoub, Riaz, Muhammad, Rickard, Jennifer, Rodriguez, Jefferson Antonio Buendia, Roever, Leonardo, Ronfani, Luca, Roy, Bedanta, S, Manjula, Saad, Aly M A, Sabour, Siamak, Sabzmakan, Leila, Saddik, Basema, Sadeghi, Malihe, Saeb, Mohammad Reza, Saeed, Umar, Saeedi Moghaddam, Sahar, Safi, Sher Zaman, Sahiledengle, Biniyam, Sahoo, Harihar, Sahraian, Mohammad Ali, Saki, Morteza, Salamati, Payman, Salehi, Sana, Salem, Marwa Rashad, Samy, Abdallah M, Sanabria, Juan, Santric-Milicevic, Milena M, Saqib, Muhammad Arif Nadeem, Sarikhani, Yaser, Sarveazad, Arash, Sathian, Brijesh, Satpathy, Maheswar, Saya, Ganesh Kumar, Schneider, Ione Jayce Ceola, Schwebel, David C, Seddighi, Hamed, Senthilkumaran, Subramanian, Seylani, Allen, Shabaninejad, Hosein, Shafeghat, Melika, Shah, Pritik A, Shahabi, Saeed, Shahbandi, Ataollah, Shahraki-Sanavi, Fariba, Shaikh, Masood Ali, Shaker, Elaheh, Shams-Beyranvand, Mehran, Shanawaz, Mohd, Shannawaz, Mohammed, Sharew, Mequannent Melaku Sharew, Sharma, Neeraj, Shashamo, Bereket Beyene, Shayan, Maryam, Sheikhi, Rahim Ali, Shen, Jiabin, Shetty, B Suresh Kumar, Shetty, Pavanchand H, Shin, Jae Il, Shitaye, Nebiyu Aniley, Shivakumar, K M, Shobeiri, Parnian, Shorofi, Seyed Afshin, Shrestha, Sunil, Siabani, Soraya, Sidemo, Negussie Boti, Simegn, Wudneh, Sinaei, Ehsan, Singh, Paramdeep, Sinto, Robert, Siraj, Md Shahjahan, Skryabin, Valentin Yurievich, Skryabina, Anna Aleksandrovna, Sleet, David A, S N, Chandan, Socea, Bogdan, Solmi, Marco, Solomon, Yonatan, Song, Yi, Sousa, Raúl A R C, Soyiri, Ireneous N, Stokes, Mark A, Suleman, Muhammad, Suliankatchi Abdulkader, Rizwan, Sun, Jing, Szócska, Miklós, Tabarés-Seisdedos, Rafael, Tabatabaei, Seyyed Mohammad, Tabish, Mohammad, Taheri, Ensiyeh, Taheri Soodejani, Moslem, Tampa, Mircea, Tan, Ker-Kan, Tarigan, Ingan Ukur, Tariqujjaman, Md, Tat, Nathan Y, Tat, Vivian Y, Tavakoli, Arash, Tefera, Belay Negash, Tefera, Yibekal Manaye, Temesgen, Gebremaryam, Temsah, Mohamad-Hani, Thangaraju, Pugazhenthan, Thapar, Rekha, Thomas, Nikhil Kenny, Ticoalu, Jansje Henny Vera, Tincho, Marius Belmondo, Tiyuri, Amir, Togtmol, Munkhsaikhan, Tovani-Palone, Marcos Roberto, Tran, Mai Thi Ngoc, Ullah, Sana, Ullah, Saif, Ullah, Irfan, Umakanthan, Srikanth, Unnikrishnan, Bhaskaran, Upadhyay, Era, Valadan Tahbaz, Sahel, Valdez, Pascual R, Vasankari, Tommi Juhani, Vaziri, Siavash, Veroux, Massimiliano, Vervoort, Dominique, Violante, Francesco S, Vlassov, Vasily, Vu, Linh Gia, Waheed, Yasir, Wang, Yanzhong, Wang, Yuan-Pang, Wang, Cong, Wiangkham, Taweewat, Wickramasinghe, Nuwan Darshana, Woday, Abay Tadesse, Wu, Ai-Min, Yahya, Gahin Abdulraheem Tayib, Yahyazadeh Jabbari, Seyed Hossein, Yang, Lin, Yaya, Sanni, Yigit, Arzu, Yiğit, Vahit, Yisihak, Eshetu, Yonemoto, Naohiro, You, Yuyi, Younis, Mustafa Z, Yu, Chuanhua, Yunusa, Ismaeel, Yusefi, Hossein, Zahir, Mazyar, Zaman, Sojib Bin, Zare, Iman, Zarea, Kourosh, Zastrozhin, Mikhail Sergeevich, Zhang, Zhi-Jiang, Zhang, Yunquan, Ziapour, Arash, Zodpey, Sanjay, Zoladl, Mohammad, Patton, George C, and Ivers, Rebecca Q

Published
2022
Full Text
View/download PDF

4. Relationship between outcomes and processes in patients with chronic low back pain plus depressive symptoms: idiographic analyses within a randomized controlled trial.

Author

Sanabria-Mazo, Juan P., Giné-Vázquez, Iago, Cristobal-Narváez, Paula, Suso-Ribera, Carlos, García-Palacios, Azucena, McCracken, Lance M., Hayes, Steven C., Hofmann, Stefan G., Ciarrochi, Joseph, and Luciano, Juan V.

Subjects
*ACCEPTANCE & commitment therapy, *PSYCHOTHERAPY, *CHRONIC pain, *BEHAVIOR therapy, *COGNITIVE therapy
Abstract

ObjectiveMethodsResultsConclusionsThis study explored the extent to which within-patient changes in processes targeted in Acceptance and Commitment Therapy (ACT) and Behavioral Activation Therapy for Depression (BATD) are associated with changes within-patient in pain intensity and depressed mood and evaluated the extent that process-outcome relationships differed between patients.An idiographic analysis embedded within a randomized controlled trial comparing ACT, BATD, and treatment-as-usual (TAU) was conducted to examine the strength of the relationship between outcomes and process variables in patients with chronic low back pain (CLBP) plus depressive symptoms. Based on data from ecological momentary assessment in patients (n = 82), the level of heterogeneity and the pooled effects of these relationships during the intervention period (70 days) were explored.Overall, a high level of heterogeneity was identified in the relationship between pain intensity or depressed mood and psychological inflexibility or behavioral activation. Individual differences in the relationships between outcomes and process variables were identified in individual people during the intervention period. These individual differences appear independent of the group (ACT, BATD, and TAU) and other definable differences (responders/non-responders, completers/non-completers, and clinical depression/non-clinical depression).These findings suggest the potential utility of personalizing psychological interventions according to the therapeutic needs of these patients. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

5. Heterogeneity in the Effectiveness of Non-pharmaceutical Interventions During the First SARS-CoV2 Wave in the United States

Author

William K. Pan, Daniel Fernández, Stefanos Tyrovolas, Giné-Vázquez Iago, Rishav Raj Dasgupta, Benjamin F. Zaitchik, Paul M. Lantos, and Christopher W. Woods

Subjects
SARS-CoV-2, non-pharmaceutical intervention (NPI), doubling time, mortality rate, United States, Public aspects of medicine, RA1-1270
Abstract

Background: Attempts to quantify effect sizes of non-pharmaceutical interventions (NPI) to control COVID-19 in the US have not accounted for heterogeneity in social or environmental factors that may influence NPI effectiveness. This study quantifies national and sub-national effect sizes of NPIs during the early months of the pandemic in the US.Methods: Daily county-level COVID-19 cases and deaths during the first wave (January 2020 through phased removal of interventions) were obtained. County-level cases, doubling times, and death rates were compared to four increasingly restrictive NPI levels. Socio-demographic, climate and mobility factors were analyzed to explain and evaluate NPI heterogeneity, with mobility used to approximate NPI compliance. Analyses were conducted separately for the US and for each Census regions (Pacific, Mountain, east/West North Central, East/West South Central, South Atlantic, Middle Atlantic and New England). A stepped-wedge cluster-randomized trial analysis was used, leveraging the phased implementation of policies.Results: Aggressive (level 4) NPIs were associated with slower COVID-19 propagation, particularly in high compliance counties. Longer duration of level 4 NPIs was associated with lower case rates (log beta −0.028, 95% CI −0.04 to −0.02) and longer doubling times (log beta 0.02, 95% CI 0.01–0.03). Effects varied by Census region, for example, level 4 effects on doubling time in Pacific states were opposite to those in Middle Atlantic and New England states. NPI heterogeneity can be explained by differential timing of policy initiation and by variable socio-demographic county characteristics that predict compliance, particularly poverty and racial/ethnic population. Climate exhibits relatively consistent relationships across Census regions, for example, higher minimum temperature and specific humidity were associated with lower doubling times and higher death rates for this period of analysis in South Central, South Atlantic, Middle Atlantic, and New England states.Conclusion and Relevance: Heterogeneity exists in both the effectiveness of NPIs across US Census regions and policy compliance. This county-level variability indicates that control strategies are best designed at community-levels where policies can be tuned based on knowledge of local disparities and compliance with public health ordinances.

Published
2021
Full Text
View/download PDF

7. Pain rates in general population for the period 1991–2015 and 10-years prediction: results from a multi-continent age-period-cohort analysis

Author

Guido, Davide, Leonardi, Matilde, Mellor-Marsá, Blanca, Moneta, Maria V., Sanchez-Niubo, Albert, Tyrovolas, Stefanos, Giné-Vázquez, Iago, Haro, Josep M., Chatterji, Somnath, Bobak, Martin, Ayuso-Mateos, Jose L., Arndt, Holger, Koupil, Ilona, Bickenbach, Jerome, Koskinen, Seppo, Tobiasz-Adamczyk, Beata, Panagiotakos, Demosthenes, and Raggi, Alberto

Published
2020
Full Text
View/download PDF

8. Predictors of pain in general ageing populations: results from a multi-country analysis based on ATHLOS harmonized database

Author

Raggi, Alberto, Leonardi, Matilde, Mellor-Marsá, Blanca, Moneta, Maria V., Sanchez-Niubo, Albert, Tyrovolas, Stefanos, Giné-Vázquez, Iago, Haro, Josep M., Chatterji, Somnath, Bobak, Martin, Ayuso-Mateos, Jose L., Arndt, Holger, Hossin, Muhammad Z., Bickenbach, Jerome, Koskinen, Seppo, Tobiasz-Adamczyk, Beata, Panagiotakos, Demosthenes, and Corso, Barbara

Published
2020
Full Text
View/download PDF

9. Effectiveness of a mental health stepped-care programme for healthcare workers with psychological distress in crisis settings: a multicentre randomised controlled trial

Author

Mediavilla, Roberto, primary, Felez-Nobrega, Mireia, additional, McGreevy, Kerry R, additional, Monistrol-Mula, Anna, additional, Bravo-Ortiz, María-Fe, additional, Bayón, Carmen, additional, Giné-Vázquez, Iago, additional, Villaescusa, Rut, additional, Muñoz-Sanjosé, Ainoa, additional, Aguilar-Ortiz, Salvatore, additional, Figueiredo, Natasha, additional, Nicaise, Pablo, additional, Park, A-La, additional, Petri-Romão, Papoula, additional, Purgato, Marianna, additional, Witteveen, Anke B, additional, Underhill, James, additional, Barbui, Corrado, additional, Bryant, Richard, additional, Kalisch, Raffael, additional, Lorant, Vincent, additional, McDaid, David, additional, Melchior, Maria, additional, Sijbrandij, Marit, additional, Haro, Josep Maria, additional, and Ayuso-Mateos, Jose Luis, additional

Published
2023
Full Text
View/download PDF

10. Government interventions and control policies to contain the first COVID-19 outbreak: An analysis of evidence

Author

Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, Universitat Politècnica de Catalunya. GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica, Fernández Martínez, Daniel, Giné Vázquez, Iago, Morena, Marianthi, Koyanagi, Ai, Janko, Mark M., Haro, Josep Maria, Panagiotakos, Demosthenes, Molassiotis, Alex, Pan, William, Tyrovolas, Stefanos, Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, Universitat Politècnica de Catalunya. GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica, Fernández Martínez, Daniel, Giné Vázquez, Iago, Morena, Marianthi, Koyanagi, Ai, Janko, Mark M., Haro, Josep Maria, Panagiotakos, Demosthenes, Molassiotis, Alex, Pan, William, and Tyrovolas, Stefanos

Abstract

Background: The overarching aim of this study was to evaluate the effectiveness over time of government interventions and policy restrictions and the impact of determinants on spread and mortality during the first-wave of the COVID-19 pandemic, globally, regionally and by country-income level, up to 18 May 2020. Methods: We created a global database merging World Health Organization daily case reports (from 218 countries/territories) with other socio-demographic and population health measures from 21 January to 18 May 2020. A four-level government policy interventions score (low to very high) was created based on the Oxford Stringency Index. Results: Our results support the use of very high government interventions to suppress both COVID-19 spread and mortality effectively during wave one globally compared to other policy levels of control. Similar trends in virus propagation and mortality were observed in all country-income levels and specific regions. Conclusions: Rapid implementation of government interventions was needed to contain the first wave of the COVID-19 outbreak and to reduce COVID-19-related mortality., Peer Reviewed, Postprint (author's final draft)

Published
2023

11. Effectiveness of a mental health stepped-care programme for healthcare workers with psychological distress in crisis settings: a multicentre randomised controlled trial

Author

Mediavilla, Roberto, Felez-Nobrega, Mireia, Mcgreevy, Kerry R, Monistrol-Mula, Anna, Bravo-Ortiz, María-Fe, Bayón, Carmen, Giné-Vázquez, Iago, Villaescusa, Rut, Muñoz-Sanjosé, Ainoa, Aguilar-Ortiz, Salvatore, Figueiredo, Natasha, Nicaise, Pablo, Park, A-La, Petri-Romão, Papoula, Purgato, Marianna, Witteveen, Anke B, Underhill, James, Barbui, Corrado, Bryant, Richard, Kalisch, Raffael, Lorant, Vincent, Mcdaid, David, Melchior, Maria, Sijbrandij, Marit, Haro, Josep Maria, Ayuso-Mateos, Jose Luis, and UCL - SSS/IRSS - Institut de recherche santé et société

Subjects
anxiety disorders, depression & mood disorders, MHSR, RA0421 Public health. Hygiene. Preventive Medicine, COVID-19, adult psychiatry, depression &amp, mood disorders
Abstract

Background: Evidence-based mental health interventions to support healthcare workers (HCWs) in crisis settings are scarce. Objective: To evaluate the capacity of a mental health intervention in reducing anxiety and depression symptoms in HCWs, relative to enhanced care as usual (eCAU), amidst the COVID-19 pandemic. Methods: We conducted an analyst-blind, parallel, multicentre, randomised controlled trial. We recruited HCWs with psychological distress from Madrid and Catalonia (Spain). The intervention arm received a stepped-care programme consisting of two WHO-developed interventions adapted for HCWs: Doing What Matters in Times of Stress (DWM) and Problem Management Plus (PM+). Each intervention lasted 5 weeks and was delivered remotely by non-specialist mental health providers. HCWs reporting psychological distress after DWM completion were invited to continue to PM+. The primary endpoint was self-reported anxiety/ depression symptoms (Patient Health Questionnaire-Anxiety and Depression Scale) at week 21. Findings: Between 3 November 2021 and 31 March 2022, 115 participants were randomised to stepped care and 117 to eCAU (86% women, mean age 37.5). The intervention showed a greater decrease in anxiety/depression symptoms compared with eCAU at the primary endpoint (baseline-adjusted difference 4.4, 95% CI 2.1 to 6.7; standardised effect size 0.8, 95% CI 0.4 to 1.2). No serious adverse events occurred. Conclusions: Brief stepped-care psychological interventions reduce anxiety and depression during a period of stress among HCWs. Clinical implications Our results can inform policies and actions to protect the mental health of HCWs during major health crises and are potentially rapidly replicable in other settings where workers are affected by global emergencies. Trial registration number NCT04980326.

Published
2023

12. Methodological challenges in harmonisation of the variables used as indicators of social capital in epidemiological studies of ageing – results of the ATHLOS project.

Author

Zawisza, Katarzyna, Woźniak, Barbara, Tobiasz-Adamczyk, Beata, Galas, Aleksander, Giné-Vázquez, Iago, Sanchez-Niubo, Albert, Ayuso-Mateos, José Luis, Koskinen, Seppo, Leonardi, Matilde, Bobak, Martin, and Haro, Josep Maria

Subjects
SOCIAL capital, SOCIAL sciences, SURVEYS, RESEARCH funding, DESCRIPTIVE statistics, CONCEPTS, MEDICAL research, LONGITUDINAL method, TRUST
Abstract

The present article aims to highlight methodological aspects related to understanding and conceptualising social capital for the purposes of population research as well as describing the key challenges in the harmonisation process of indicators of social capital. The study was conducted in the frame of the Ageing Trajectories of Health: Longitudinal Opportunities and Synergies (ATHLOS) project. After a review of social capital theories developed in social science and a subsequent review of the documentation of 18 international cohorts, decision trees of the harmonisation of social variables were developed. The known-group validity was verified. The results focused on generalised trust, civic engagement and social participation are presented. The summary of the availability of any indicators of these concepts is classified in seven domains (generalised trust, political participation, religious participation, senior-specific participation, participation in sport groups, participation in volunteer/charity group activities, any participation) across surveys. The results of the analysis for known-group validity support the construct validity of the harmonised variables. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

15. The Impact of COVID-19 Lockdown on Adults with Major Depressive Disorder from Catalonia: A Decentralized Longitudinal Study

Author

Lavalle, Raffaele, Condominas, Elena, Haro, Josep Maria, Giné-Vázquez, Iago, Bailon, Raquel, Laporta, Estela, Garcia, Ester, Kontaxis, Spyridon, Alacid, Gemma Riquelme, Lombardini, Federica, Preti, Antonio, Peñarrubia-Maria, Maria Teresa, Coromina, Marta, Arranz, Belén, Vilella, Elisabet, Rubio-Alacid, Elena, Radar-Mdd Spain, Matcham, Faith, Lamers, Femke, Hotopf, Matthew, Penninx, Brenda W. J. H., Annas, Peter, Narayan, Vaibhav, Simblett, Sara K., Siddi, Sara, The Radar-Cns Consortium, Psychiatry, APH - Digital Health, APH - Mental Health, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, and Amsterdam Neuroscience - Complex Trait Genetics

Subjects
Health, Toxicology and Mutagenesis, Public Health, Environmental and Occupational Health, SARS-CoV-2, depression, anxiety, lockdown, quarantine, remote measurement technology, decentralized study, Spain
Abstract

The present study analyzes the effects of each containment phase of the first COVID-19 wave on depression levels in a cohort of 121 adults with a history of major depressive disorder (MDD) from Catalonia recruited from 1 November 2019, to 16 October 2020. This analysis is part of the Remote Assessment of Disease and Relapse-MDD (RADAR-MDD) study. Depression was evaluated with the Patient Health Questionnaire-8 (PHQ-8), and anxiety was evaluated with the Generalized Anxiety Disorder-7 (GAD-7). Depression’s levels were explored across the phases (pre-lockdown, lockdown, and four post-lockdown phases) according to the restrictions of Spanish/Catalan governments. Then, a mixed model was fitted to estimate how depression varied over the phases. A significant rise in depression severity was found during the lockdown and phase 0 (early post-lockdown), compared with the pre-lockdown. Those with low pre-lockdown depression experienced an increase in depression severity during the “new normality”, while those with high pre-lockdown depression decreased compared with the pre-lockdown. These findings suggest that COVID-19 restrictions affected the depression level depending on their pre-lockdown depression severity. Individuals with low levels of depression are more reactive to external stimuli than those with more severe depression, so the lockdown may have worse detrimental effects on them.

Published
2023
Full Text
View/download PDF

16. sj-docx-1-sjp-10.1177_14034948231156969 – Supplemental material for Government interventions and control policies to contain the first COVID-19 outbreak: An analysis of evidence

Author

Fernández, Daniel, Giné-Vázquez, Iago, Morena, Marianthi, Koyanagi, AI, Janko, Mark M., Haro, Josep Maria, Panagiotakos, Demosthenes, Molassiotis, Alex, Pan, William K., and Tyrovolas, Stefanos

Subjects
111799 Public Health and Health Services not elsewhere classified, FOS: Health sciences
Abstract

Supplemental material, sj-docx-1-sjp-10.1177_14034948231156969 for Government interventions and control policies to contain the first COVID-19 outbreak: An analysis of evidence by Daniel Fernández, Iago Giné-Vázquez, Marianthi Morena, AI Koyanagi, Mark M. Janko, Josep Maria Haro, Demosthenes Panagiotakos, Alex Molassiotis, William K. Pan and Stefanos Tyrovolas in Scandinavian Journal of Public Health

Published
2023
Full Text
View/download PDF

17. Biopsychosocial Response to the COVID-19 Lockdown in People with Major Depressive Disorder and Multiple Sclerosis

Author

Siddi, Sara, Giné-Vázquez, Iago, Bailon, Raquel, Matcham, Faith, Lamers, Femke, Kontaxis, Spyridon, Laporta, Estela, Garcia, Esther, Arranz, Belen, Dalla Costa, Gloria, Guerrero, Ana Isabel, Zabalza, Ana, Buron, Mathias Due, Comi, Giancarlo, Leocani, Letizia, Annas, Peter, Hotopf, Matthew, Penninx, Brenda W J H, Magyari, Melinda, Sørensen, Per S, Montalban, Xavier, Lavelle, Grace, Ivan, Alina, Oetzmann, Carolin, White, Katie M, Difrancesco, Sonia, Locatelli, Patrick, Mohr, David C, Aguiló, Jordi, Narayan, Vaibhav, Folarin, Amos, Dobson, Richard J B, Dineley, Judith, Leightley, Daniel, Cummins, Nicholas, Vairavan, Srinivasan, Ranjan, Yathart, Rashid, Zulqarnain, Rintala, Aki, Girolamo, Giovanni De, Preti, Antonio, Simblett, Sara, Wykes, Til, Pab Members, Null, Myin-Germeys, Inez, Haro, Josep Maria, On Behalf Of The Radar-Cns Consortium, Null, Psychiatry, APH - Mental Health, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Amsterdam Neuroscience - Complex Trait Genetics, and APH - Digital Health

Subjects
stress, COVID-19, SARS-CoV-2, major depressive disorder, multiple sclerosis, depression severity, heart rate, social activity, physical activity, decentralized, General Medicine
Abstract

Changes in lifestyle, finances and work status during COVID-19 lockdownsmay have led to biopsychosocial changes in people with pre-existing vulnerabilities such as MajorDepressive Disorders (MDDs) and Multiple Sclerosis (MS). Methods: Data were collected as a part the RADAR-CNS (Remote Assessment of Disease and Relapse-Central Nervous System) program.We analyzed the following data from long-term participants in a decentralized multinational study:J. Clin. Med. 2022, 11, 7163. https://doi.org/10.3390/jcm11237163 https://www.mdpi.com/journal/jcm J. Clin. Med. 2022, 11, 7163 2 of 20 symptoms of depression, heart rate (HR) during the day and night; social activity; sedentary state,steps and physical activity of varying intensity. Linear mixed-effects regression analyses with repeated measures were fitted to assess the changes among three time periods (pre, during and post-lockdown) across the groups, adjusting for depression severity before the pandemic and gender. Results: Participants with MDDs (N = 255) and MS (N = 214) were included in the analyses. Overall,depressive symptoms remained stable across the three periods in both groups. A lower mean HR and HR variation were observed between pre and during lockdown during the day for MDDs and during the night for MS. HR variation during rest periods also decreased between pre- and post-lockdown in both clinical conditions. We observed a reduction in physical activity for MDDs and MS upon the introduction of lockdowns. The group with MDDs exhibited a net increase in social interaction via social network apps over the three periods. Conclusions: Behavioral responses to the lockdown measured by social activity, physical activity and HR may reflect changes in stress in people with MDDs and MS. Remote technology monitoring might promptly activate an early warning of physical and social alterations in these stressful situations. Future studies must explore how stress does or does not impact depression severity

Published
2022
Full Text
View/download PDF

18. Factors Associated with Depression and Anxiety Symptoms among Migrant Population in Spain during the COVID-19 Pandemic

Author

Bayes-Marin, Ivet, primary, Roura-Adserias, Maria, additional, Giné-Vázquez, Iago, additional, Villalobos, Felipe, additional, Franch-Roca, Marta, additional, Lloret-Pineda, Amanda, additional, Gabarrell-Pascuet, Aina, additional, He, Yuelu, additional, Hafi, Rachid El, additional, Butt, Fajar Matloob Ahmed, additional, Mellor-Marsá, Blanca, additional, Alós, M. Carmen, additional, Sainz-Elías, Helena, additional, Ayad-Ahmed, Wala, additional, Aparicio, Lola, additional, Cabeza, Mercedes Espinal, additional, Bobo, Óscar Álvarez, additional, López, Yolanda Osorio, additional, Haro, Josep Maria, additional, and Cristóbal-Narváez, Paula, additional

Published
2022
Full Text
View/download PDF

19. Methodological challenges in harmonisation of the variables used as indicators of social capital in epidemiological studies of ageing – results of the ATHLOS project

Author

Zawisza, Katarzyna, primary, Woźniak, Barbara, additional, Tobiasz-Adamczyk, Beata, additional, Galas, Aleksander, additional, Giné-Vázquez, Iago, additional, Sanchez-Niubo, Albert, additional, Ayuso-Mateos, José Luis, additional, Koskinen, Seppo, additional, Leonardi, Matilde, additional, Bobak, Martin, additional, and Haro, Josep Maria, additional

Published
2021
Full Text
View/download PDF

20. A GBD 2019 study of health and Sustainable Development Goal gains and forecasts to 2030 in Spain.

Author

Lazarus, Jeffrey V., Ortiz, Alberto, Tyrovolas, Stefanos, Fernández, Esteve, Guy, Danielle, White, Trenton M., Ma, Rui, Hay, Simon I., Naghavi, Mohsen, Soriano, Joan B., The GBD 2019 Spain Collaborators, García-Basteiro, Alberto L., Ayuso-Mateos, Jose L., Bassat, Quique, Benavides, Fernando G., Giné-Vázquez, Iago, Haro, Josep Maria, Koyanagi, Ai, Martinez-Raga, Jose, and Padron-Monedero, Alicia

Subjects
SUSTAINABLE development, ALZHEIMER'S disease, CHRONIC obstructive pulmonary disease, LUMBAR pain, BODY mass index
Abstract

This study aimed to report mortality, risk factors, and burden of diseases in Spain. The Global Burden of Disease, Injuries, and Risk Factors 2019 estimates the burden due to 369 diseases, injuries, and impairments and 87 risk factors and risk factor combinations. Here, we detail the updated Spain 1990–2019 burden of disease estimates and project certain metrics up to 2030. In 2019, leading causes of death were ischaemic heart disease, stroke, chronic obstructive pulmonary disease, Alzheimer's disease, and lung cancer. Main causes of disability adjusted life years (DALYs) were ischaemic heart disease, diabetes, lung cancer, low back pain, and stroke. Leading DALYs risk factors included smoking, high body mass index, and high fasting plasma glucose. Spain scored 74/100 among all health-related Sustainable Development Goals (SDGs) indicators, ranking 20 of 195 countries and territories. We forecasted that by 2030, Spain would outpace Japan, the United States, and the European Union. Behavioural risk factors, such as smoking and poor diet, and environmental factors added a significant burden to the Spanish population's health in 2019. Monitoring these trends, particularly in light of COVID-19, is essential to prioritise interventions that will reduce the future burden of disease to meet population health and SDG commitments. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

22. Development of a common scale for measuring healthy ageing across the world : results from the ATHLOS consortium

Author

Sanchez-Niubo, Albert, Forero, Carlos G, Wu, Yu-Tzu, Giné-Vázquez, Iago, Prina, Matthew, De La Fuente, Javier, Daskalopoulou, Christina, Critselis, Elena, De La Torre-Luque, Alejandro, Panagiotakos, Demosthenes, Arndt, Holger, Ayuso-Mateos, José Luis, Bayes-Marin, Ivet, Bickenbach, Jerome, Bobak, Martin, Caballero, Francisco Félix, Chatterji, Somnath, Egea-Cortés, Laia, García-Esquinas, Esther, Leonardi, Matilde, Koskinen, Seppo, Koupil, Ilona, Mellor-Marsá, Blanca, Olaya, Beatriz, Pająk, Andrzej, Prince, Martin, Raggi, Alberto, Rodríguez-Artalejo, Fernando, Sanderson, Warren, Scherbov, Sergei, Tamosiunas, Abdonas, Tobias-Adamczyk, Beata, Tyrovolas, Stefanos, Haro, Josep Maria, Sanchez-Niubo, Albert, Forero, Carlos G, Wu, Yu-Tzu, Giné-Vázquez, Iago, Prina, Matthew, De La Fuente, Javier, Daskalopoulou, Christina, Critselis, Elena, De La Torre-Luque, Alejandro, Panagiotakos, Demosthenes, Arndt, Holger, Ayuso-Mateos, José Luis, Bayes-Marin, Ivet, Bickenbach, Jerome, Bobak, Martin, Caballero, Francisco Félix, Chatterji, Somnath, Egea-Cortés, Laia, García-Esquinas, Esther, Leonardi, Matilde, Koskinen, Seppo, Koupil, Ilona, Mellor-Marsá, Blanca, Olaya, Beatriz, Pająk, Andrzej, Prince, Martin, Raggi, Alberto, Rodríguez-Artalejo, Fernando, Sanderson, Warren, Scherbov, Sergei, Tamosiunas, Abdonas, Tobias-Adamczyk, Beata, Tyrovolas, Stefanos, and Haro, Josep Maria

Abstract

BACKGROUND: Research efforts to measure the concept of healthy ageing have been diverse and limited to specific populations. This diversity limits the potential to compare healthy ageing across countries and/or populations. In this study, we developed a novel measurement scale of healthy ageing using worldwide cohorts. METHODS: In the Ageing Trajectories of Health-Longitudinal Opportunities and Synergies (ATHLOS) project, data from 16 international cohorts were harmonized. Using ATHLOS data, an item response theory (IRT) model was used to develop a scale with 41 items related to health and functioning. Measurement heterogeneity due to intra-dataset specificities was detected, applying differential item functioning via a logistic regression framework. The model accounted for specificities in model parameters by introducing cohort-specific parameters that rescaled scores to the main scale, using an equating procedure. Final scores were estimated for all individuals and converted to T-scores with a mean of 50 and a standard deviation of 10. RESULTS: A common scale was created for 343 915 individuals above 18 years of age from 16 studies. The scale showed solid evidence of concurrent validity regarding various sociodemographic, life and health factors, and convergent validity with healthy life expectancy (r = 0.81) and gross domestic product (r = 0.58). Survival curves showed that the scale could also be predictive of mortality. CONCLUSIONS: The ATHLOS scale, due to its reliability and global representativeness, has the potential to contribute to worldwide research on healthy ageing.

Published
2021
Full Text
View/download PDF

23. Heterogeneity in the effectiveness of non-pharmaceutical interventions during the first SARS-CoV2 wave in the United States

Author

Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, Universitat Politècnica de Catalunya. GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica, Pan, William, Fernández Martínez, Daniel, Tyrovolas, Stefanos, Giné Vázquez, Iago, Dasgupta, Rishav Raj, Zaitchik, Benjamin F., Lantos, Paul M., Woods, Christopher W., Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, Universitat Politècnica de Catalunya. GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica, Pan, William, Fernández Martínez, Daniel, Tyrovolas, Stefanos, Giné Vázquez, Iago, Dasgupta, Rishav Raj, Zaitchik, Benjamin F., Lantos, Paul M., and Woods, Christopher W.

Abstract

Background: Attempts to quantify effect sizes of non-pharmaceutical interventions (NPI) to control COVID-19 in the US have not accounted for heterogeneity in social or environmental factors that may influence NPI effectiveness. This study quantifies national and sub-national effect sizes of NPIs during the early months of the pandemic in the US. Methods: Daily county-level COVID-19 cases and deaths during the first wave (January 2020 through phased removal of interventions) were obtained. County-level cases, doubling times, and death rates were compared to four increasingly restrictive NPI levels. Socio-demographic, climate and mobility factors were analyzed to explain and evaluate NPI heterogeneity, with mobility used to approximate NPI compliance. Analyses were conducted separately for the US and for each Census regions (Pacific, Mountain, east/West North Central, East/West South Central, South Atlantic, Middle Atlantic and New England). A stepped-wedge cluster-randomized trial analysis was used, leveraging the phased implementation of policies. Results: Aggressive (level 4) NPIs were associated with slower COVID-19 propagation, particularly in high compliance counties. Longer duration of level 4 NPIs was associated with lower case rates (log beta -0.028, 95% CI -0.04 to -0.02) and longer doubling times (log beta 0.02, 95% CI 0.01–0.03). Effects varied by Census region, for example, level 4 effects on doubling time in Pacific states were opposite to those in Middle Atlantic and New England states. NPI heterogeneity can be explained by differential timing of policy initiation and by variable socio-demographic county characteristics that predict compliance, particularly poverty and racial/ethnic population. Climate exhibits relatively consistent relationships across Census regions, for example, higher minimum temperature and specific humidity were associated with lower doubling times and higher death rates for this period of analysis in South Central, South Atlantic, Peer Reviewed, Postprint (published version)

Published
2021

24. Are environmental pollution and biodiversity levels associated to the spread and mortality of COVID-19? A four-month global analysis

Author

Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, Universitat Politècnica de Catalunya. Departament de Ciència i Enginyeria de Materials, Universitat Politècnica de Catalunya. GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica, Fernández Martínez, Daniel, Giné Vázquez, Iago, Liu, Ivy, Yucel, Recai, Nai Ruscone, Marta, Morena, Marianthi, García Fernández, Víctor Gerardo, Haro, Josep Maria, Pan, William, Tyrovolas, Stefanos, Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, Universitat Politècnica de Catalunya. Departament de Ciència i Enginyeria de Materials, Universitat Politècnica de Catalunya. GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica, Fernández Martínez, Daniel, Giné Vázquez, Iago, Liu, Ivy, Yucel, Recai, Nai Ruscone, Marta, Morena, Marianthi, García Fernández, Víctor Gerardo, Haro, Josep Maria, Pan, William, and Tyrovolas, Stefanos

Abstract

On March 12th, 2020, the WHO declared COVID-19 as a pandemic. The collective impact of environ-mental and ecosystem factors, as well as biodiversity, on the spread of COVID-19 and its mortalityevolution remain empirically unknown, particularly in regions with a wide ecosystem range. The aim ofour study is to assess how those factors impact on the COVID-19 spread and mortality by country. Thisstudy compiled a global database merging WHO daily case reports with other publicly available measuresfrom January 21st to May 18th, 2020. We applied spatio-temporal models to identify the influence ofbiodiversity, temperature, and precipitation andfitted generalized linear mixed models to identify theeffects of environmental variables. Additionally, we used count time series to characterize the associationbetween COVID-19 spread and air quality factors. All analyses were adjusted by social demographic,country-income level, and government policy intervention confounders, among 160 countries, globally.Our results reveal a statistically meaningful association between COVID-19 infection and several factorsof interest at country and city levels such as the national biodiversity index, air quality, and pollutantselements (PM10,PM2.5,and O3). Particularly, there is a significant relationship of loss of biodiversity, highlevel of air pollutants, and diminished air quality with COVID-19 infection spread and mortality. Ourfindings provide an empirical foundation for future studies on the relationship between air qualityvariables, a country’s biodiversity, and COVID-19 transmission and mortality. The relationships measuredin this study can be valuable when governments plan environmental and health policies, as alternativestrategy to respond to new COVID-19 outbreaks and prevent future crises, Daniel Fernández supported by grant 2017 SGR 622 (GRBIO) administrated by the Departament d’Economia i Coneixement de la Generalitat de Catalunya (Spain), Peer Reviewed, Postprint (author's final draft)

Published
2021

25. Estimating the COVID-19 spread through real-time population mobility patterns: surveillance in low- and middle-income countries

Author

Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, Universitat Politècnica de Catalunya. GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica, Tyrovolas, Stefanos, Giné Vázquez, Iago, Fernández Martínez, Daniel, Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, Universitat Politècnica de Catalunya. GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica, Tyrovolas, Stefanos, Giné Vázquez, Iago, and Fernández Martínez, Daniel

Abstract

Background: On January 21, 2020, the World Health Organization reported the first case of severe acute respiratory syndrome coronavirus 2, which rapidly evolved to the COVID-19 pandemic. Since then, the virus has also rapidly spread among Latin American, Caribbean, and African countries. Objective: The first aim of this study is to identify new emerging COVID-19 clusters over time and space (from January 21 to mid-May 2020) in Latin American, Caribbean, and African regions, using a prospective space–time scan measurement approach. The second aim is to assess the impact of real-time population mobility patterns between January 21 and May 18, 2020, under the implemented government interventions, measurements, and policy restrictions on COVID-19 spread among those regions and worldwide. Methods: We created a global COVID-19 database, of 218 countries and territories, merging the World Health Organization daily case reports with other measures such as population density and country income levels for January 21 to May 18, 2020. A score of government policy interventions was created for low, intermediate, high, and very high interventions. The population’s mobility patterns at the country level were obtained from Google community mobility reports. The prospective space–time scan statistic method was applied in five time periods between January and May 2020, and a regression mixed model analysis was used. Results: We found that COVID-19 emerging clusters within these five periods of time increased from 7 emerging clusters to 28 by mid-May 2020. We also detected various increasing and decreasing relative risk estimates of COVID-19 spread among Latin American, Caribbean, and African countries within the period of analysis. Globally, population mobility to parks and similar leisure areas during at least a minimum of implemented intermediate-level control policies (when compared to low-level control policies) was related to accelerated COVID-19 spread. Results were almost cons, DF is a Serra Húnter Fellow and was supported by Marsden grant E2987-3648 administrated by the Royal Society of New Zealand, and by grant 2017 SGR 622 (GRBIO) administrated by the Departament d'Economia i Coneixement de la Generalitat de Catalunya (Spain), Peer Reviewed, Postprint (published version)

Published
2021

26. Estimating the COVID-19 Spread Through Real-time Population Mobility Patterns: Surveillance in Low- and Middle-Income Countries

Author

Tyrovolas, Stefanos, primary, Giné-Vázquez, Iago, additional, Fernández, Daniel, additional, Morena, Marianthi, additional, Koyanagi, Ai, additional, Janko, Mark, additional, Haro, Josep Maria, additional, Lin, Yang, additional, Lee, Paul, additional, Pan, William, additional, Panagiotakos, Demosthenes, additional, and Molassiotis, Alex, additional

Published
2021
Full Text
View/download PDF

27. Global, regional, and national burden of aortic aneurysm, 1990–2017: a systematic analysis of the Global Burden of Disease Study 2017

Author

Tyrovolas, Stefanos, primary, Tyrovola, Dimitra, additional, Giné-Vázquez, Iago, additional, Koyanagi, Ai, additional, Bernabe-Ortiz, Antonio, additional, Rodriguez-Artalejo, Fernando, additional, Haro, Josep Maria, additional, Pan, William K, additional, Miranda, J Jaime, additional, and Panagiotakos, Demosthenes, additional

Published
2021
Full Text
View/download PDF

29. Estimating the COVID-19 Spread Through Real-time Population Mobility Patterns: Surveillance in Low- and Middle-Income Countries (Preprint)

Author

Tyrovolas, Stefanos, primary, Giné-Vázquez, Iago, additional, Fernández, Daniel, additional, Morena, Marianthi, additional, Koyanagi, Ai, additional, Janko, Mark, additional, Haro, Josep Maria, additional, Lin, Yang, additional, Lee, Paul, additional, Pan, William, additional, Panagiotakos, Demosthenes, additional, and Molassiotis, Alex, additional

Published
2020
Full Text
View/download PDF

31. Government Interventions and Control Policies to Contain COVID-19 Outbreak: Global Analysis of Evidence During the First 4 Months

Author

Tyrovolas, Stefanos, primary, Giné-Vázquez, Iago, additional, Daniel, Fernández, additional, Marianthi, Morena, additional, Ai, Koyanagi, additional, Janko, Mark M., additional, Haro, Josep Maria, additional, Chatterji, Somnath, additional, Panagiotakos, Demosthenes, additional, Molassiotis, Alex, additional, and William, Pan K., additional

Published
2020
Full Text
View/download PDF

32. Albanese varieties of non-Archimedean uniformized varieties

Author

Giné Vázquez, Iago, Xarles Ribas, Francesc Xavier, and Universitat Autònoma de Barcelona. Departament de Matemàtiques

Subjects
Varietats d'Albanese, Albanese varieties, Geometria analitica de Berkovich, Variedades de Albanese, Ciències Experimentals, Bruhat-Tits buildings, Berkovich analytic geometry, Edificis de Bruhat-Tits, Edificios de Bruhat-Tits
Abstract

En esta tesis doctoral ofrecemos una construcción conjetural de la variedad de Albanese de una variedad uniformizada no arquimediana fijándonos en una estructura métrica contenida en la última y llamada su esqueleto (que es, esencialmente, una curva tropical). Para ello realizamos una construcción paralela (real, tropical) sobre el esqueleto, que deviene el esqueleto de nuestra propuesta para variedad de Albanese, la subimos a una construcción analítica sobre la variedad dada y usamos que su esqueleto es el cociente de un cierto subedificio localmente finito de un edificio de Bruhat-Tits, que también aparece como el esqueleto de la variedad uniformizante. Entonces, relacionamos unas ciertas cocadenas armónicas en los edificios con las medidas armónicas en sus finales como paso clave en la demostración de que la construcción hecha es la variedad de Albanese. Esta tesis tiene dos partes principales. Una está dedicada a describir con completa generalidad esta construcción en dimensión 1, mientras en la segunda estudiamos la estructura del edificio de Bruhat-Tits y realizamos una construcción que preveemos que es la variedad de Albanese buscada, bajo la hipótesis de que el cuerpo base tiene una valoración discreta. Empezamos estudiando la Jacobiana de un grafo, en el capítulo 1 sin más estructura, en el capítulo 2 un grafo métrico. Nuestro trabajo, junto con otros, muestra que nuestra descripción de la Jacobiana de un grafo métrico en términos de integración sobre los finales del árbol métrico que es su recubrimiento universal extiende, de alguna manera, la Jacobiana (discreta) de un grafo sin estructura métrica. Aquí introducimos las cocadenas armónicas en los árboles y las medidas armónicas en los finales, y demostramos que hay un isomorfismo entre ellas como paso importante para lograr el resultado principal. En el capítulo 3 desarrollamos la teoría de curvas de Mumford y sus Jacobianas en el marco de la geometría de Berkovich, las relacionamos con sus esqueletos por medio de la aplicación de retracción e introducimos las integrales multiplicativas. Entonces extendemos a nuestras hipótesis generales varios resultados conocidos en casos particulares (por ejemplo, sobre un cuerpo base local) gracias a esas herramientas recientes, y usamos los resutados sobre la Jacobiana de un grafo métrico aplicados al esqueleto correspondiente para obtener que la construcción realizada mediante integrales multiplicativas y medidas armónicas es una variedad abeliana. Después probamos que es la Jacobiana mediante la teoría de funciones theta, desarrollada desde la perspectiva novedosa de la geometría de Berkovich usando funciones tropicales. En el capítulo 4 adaptamos esta construcción a dimensión superior, dando un candidato natural a ser la variedad de Albanese de una variedad uniformizada no arquimediana tal como construyó Mustafin como una generalización de las curvas de Mumford. Para ello extendemos la noción de grupo de Schottky a cualquier dimensión siguiendo el trabajo de Mustafin y estudiamos con detalle la estructura de los edificios de Bruhat-Tits sobre un cuerpo completo con una valoración discreta. Entonces nos retringimos a dimensión 2 para definir las cocadenas armónicas sobre ciertos subcomplejos de cámaras, y probamos que son isomorfas a las medidas armónicas sobre un cierto compacto de los puntos racionales del correspondiente espacio proyectivo cuando el subcomplejo asociado es un edificio. Finalmente, usamos esto para hacer una reducción de la demostración de que la construcción realizada es un toro analítico., In this PhD thesis, we give a conjectural construction of the Albanese variety of a non-Archimedean uniformized variety by means of looking at a metrical structure contained in the last one and called its skeleton (which is, essentially, a tropical curve). In order to do that we make a parallel (real, tropical) construction on the skeleton, which becomes the skeleton of the conjectural Albanese we were seeking for, we rise this to an analytic construction over the given variety and we use that its skeleton is the quotient of a certain locally finite subbuilding of a Bruhat-Tits building, which appears also as the skeleton of the uniformizing variety. Later, we relate the harmonic cochains on the buildings with the harmonic measures on the ends as a key step in the proof that one gets the Albanese variety. The thesis has two main parts. One is devoted to describe with complete generality this construction in dimension 1, while in the second we study the structure of the Bruhat-Tits building and we make a construction that we expect it is the Albanese variety, under the assumption that the ground field has a discrete valuation. We start by study the Jacobian of a graph, in the chapter 1 without more structure, in the chapter 2 a metric graph. Our work, together with others, shows that our description of the Jacobian of a metric graph in terms of integration on the ends of the universal covering metric tree extends in some way the (discrete) Jacobian of a graph without metric structure. Here we introduce harmonic cochains on the trees and harmonic measures on the ends, and we prove that they are isomorphic, as an important step to the main result. In the chapter 3 we develope the theory of Mumford curves and their Jacobians in the setting of Berkovich geometry, we relate them with their skeletons by means of the retraction map and we introduce the multiplicative integrals. Then, we extend to our general hypotheses several known results about them in particular cases (like for a local ground field) with those new tools, and we use the results on the Jacobian of a metric graph applied to the corresponding skeleton to get that the construction we do with multiplicative integrals and harmonic measures is an abelian variety. After that, we prove that it is the Jacobian by means of the theory of theta functions, developed from the new perspective of Berkovich geometry using tropical functions. In the chapter 4 we adapt this construction to higher dimension, giving a natural candidate to be the Albanese variety of a non-Archimedean uniformized variety as it was built by Mustafin as a generalization of Mumford curves. In order to do it, we extend the notion of Schottky group to any dimension following the work of Mustafin, and we study deeply the structure of the Bruhat-Tits buildings over a complete field with a discrete valuation. Then, we restrict to dimension 2 to define the harmonic cochains over certain chamber subcomplexes, and we prove that they are isomorphic to the harmonic measures over a certain compact set of the rational points of the corresponding projective space when the associated subcomplex is a building. Finally we use it to start to prove that the construction we do is an analytic torus.

Published
2017

33. Albanese varieties of non-Archimedean uniformized varieties

Author

Xarles Ribas, Francesc Xavier, Giné Vázquez, Iago, Universitat Autònoma de Barcelona. Departament de Matemàtiques., Xarles Ribas, Francesc Xavier, Giné Vázquez, Iago, and Universitat Autònoma de Barcelona. Departament de Matemàtiques.

Abstract

En esta tesis doctoral ofrecemos una construcción conjetural de la variedad de Albanese de una variedad uniformizada no arquimediana fijándonos en una estructura métrica contenida en la última y llamada su esqueleto (que es, esencialmente, una curva tropical). Para ello realizamos una construcción paralela (real, tropical) sobre el esqueleto, que deviene el esqueleto de nuestra propuesta para variedad de Albanese, la subimos a una construcción analítica sobre la variedad dada y usamos que su esqueleto es el cociente de un cierto subedificio localmente finito de un edificio de Bruhat-Tits, que también aparece como el esqueleto de la variedad uniformizante. Entonces, relacionamos unas ciertas cocadenas armónicas en los edificios con las medidas armónicas en sus finales como paso clave en la demostración de que la construcción hecha es la variedad de Albanese. Esta tesis tiene dos partes principales. Una está dedicada a describir con completa generalidad esta construcción en dimensión 1, mientras en la segunda estudiamos la estructura del edificio de Bruhat-Tits y realizamos una construcción que preveemos que es la variedad de Albanese buscada, bajo la hipótesis de que el cuerpo base tiene una valoración discreta. Empezamos estudiando la Jacobiana de un grafo, en el capítulo 1 sin más estructura, en el capítulo 2 un grafo métrico. Nuestro trabajo, junto con otros, muestra que nuestra descripción de la Jacobiana de un grafo métrico en términos de integración sobre los finales del árbol métrico que es su recubrimiento universal extiende, de alguna manera, la Jacobiana (discreta) de un grafo sin estructura métrica. Aquí introducimos las cocadenas armónicas en los árboles y las medidas armónicas en los finales, y demostramos que hay un isomorfismo entre ellas como paso importante para lograr el resultado principal. En el capítulo 3 desarrollamos la teoría de curvas de Mumford y sus Jacobianas en el marco de la geometría de Berkovich, las relacionamos con sus esqueletos por, In this PhD thesis, we give a conjectural construction of the Albanese variety of a non-Archimedean uniformized variety by means of looking at a metrical structure contained in the last one and called its skeleton (which is, essentially, a tropical curve). In order to do that we make a parallel (real, tropical) construction on the skeleton, which becomes the skeleton of the conjectural Albanese we were seeking for, we rise this to an analytic construction over the given variety and we use that its skeleton is the quotient of a certain locally finite subbuilding of a Bruhat-Tits building, which appears also as the skeleton of the uniformizing variety. Later, we relate the harmonic cochains on the buildings with the harmonic measures on the ends as a key step in the proof that one gets the Albanese variety. The thesis has two main parts. One is devoted to describe with complete generality this construction in dimension 1, while in the second we study the structure of the Bruhat-Tits building and we make a construction that we expect it is the Albanese variety, under the assumption that the ground field has a discrete valuation. We start by study the Jacobian of a graph, in the chapter 1 without more structure, in the chapter 2 a metric graph. Our work, together with others, shows that our description of the Jacobian of a metric graph in terms of integration on the ends of the universal covering metric tree extends in some way the (discrete) Jacobian of a graph without metric structure. Here we introduce harmonic cochains on the trees and harmonic measures on the ends, and we prove that they are isomorphic, as an important step to the main result. In the chapter 3 we develope the theory of Mumford curves and their Jacobians in the setting of Berkovich geometry, we relate them with their skeletons by means of the retraction map and we introduce the multiplicative integrals. Then, we extend to our general hypotheses several known results about them in particular cases (l

Published
2017

34. Additional file 1 of Pain rates in general population for the period 1991–2015 and 10-years prediction: results from a multi-continent age-period-cohort analysis

Author

Guido, Davide, Leonardi, Matilde, Mellor-Marsá, Blanca, Moneta, Maria V., Sanchez-Niubo, Albert, Tyrovolas, Stefanos, Giné-Vázquez, Iago, Haro, Josep M., Chatterji, Somnath, Bobak, Martin, Ayuso-Mateos, Jose L., Arndt, Holger, Koupil, Ilona, Bickenbach, Jerome, Koskinen, Seppo, Tobiasz-Adamczyk, Beata, Demosthenes Panagiotakos, and Raggi, Alberto

Subjects
3. Good health
Abstract

Additional file 1. Trends Pain – Supplementary Materials – February 10, 2020. supplementary results not included in the full text.

35. Additional file 1 of Predictors of pain in general ageing populations: results from a multi-country analysis based on ATHLOS harmonized database

Author

Raggi, Alberto, Leonardi, Matilde, Mellor-Marsá, Blanca, Moneta, Maria V., Sanchez-Niubo, Albert, Tyrovolas, Stefanos, Giné-Vázquez, Iago, Haro, Josep M., Chatterji, Somnath, Bobak, Martin, Ayuso-Mateos, Jose L., Arndt, Holger, Hossin, Muhammad Z., Bickenbach, Jerome, Koskinen, Seppo, Tobiasz-Adamczyk, Beata, Demosthenes Panagiotakos, and Corso, Barbara

Subjects
1. No poverty, 3. Good health
Abstract

Additional file 1: Table S1. Description of exploited studies and waves. Table S2. Univariable logistic regression results. Table S3. Multivariable logistic regression results. Table S4. Descriptive statistics, China Health and Retirement Longitudinal Study (CHARLS). Table S5. Descriptive statistics Collaborative Research on Ageing in Europe Study (COURAGE in Europe). Table S6. Descriptive statistics Health and Retirement Study (HRS). Table S7. Descriptive statistics Health 2000/2011 study (Health 2000/2011). Table S8. Descriptive statistics Mexican Health and Aging Study (MHAS). Table S9. Descriptive statistics Survey of Health, Ageing and Retirement in Europe (SHARE).

36. Additional file 1 of Pain rates in general population for the period 1991–2015 and 10-years prediction: results from a multi-continent age-period-cohort analysis

Author

Guido, Davide, Leonardi, Matilde, Mellor-Marsá, Blanca, Moneta, Maria V., Sanchez-Niubo, Albert, Tyrovolas, Stefanos, Giné-Vázquez, Iago, Haro, Josep M., Chatterji, Somnath, Bobak, Martin, Ayuso-Mateos, Jose L., Arndt, Holger, Koupil, Ilona, Bickenbach, Jerome, Koskinen, Seppo, Tobiasz-Adamczyk, Beata, Demosthenes Panagiotakos, and Raggi, Alberto

Subjects
3. Good health
Abstract

Additional file 1. Trends Pain – Supplementary Materials – February 10, 2020. supplementary results not included in the full text.

37. Effectiveness of a mental health stepped-care programme for healthcare workers with psychological distress in crisis settings: a multicentre randomised controlled trial

Author

Mediavilla, Roberto, Felez-Nobrega, Mireia, McGreevy, Kerry R, Monistrol-Mula, Anna, Bravo-Ortiz, María-Fe, Bayón, Carmen, Giné-Vázquez, Iago, Villaescusa, Rut, Muñoz-Sanjosé, Ainoa, Aguilar-Ortiz, Salvatore, Figueiredo, Natasha, Nicaise, Pablo, Park, A-La, Petri-Romão, Papoula, Purgato, Marianna, Witteveen, Anke B, Underhill, James, Barbui, Corrado, Bryant, Richard, Kalisch, Raffael, Lorant, Vincent, McDaid, David, Melchior, Maria, Sijbrandij, Marit, Haro, Josep Maria, Ayuso-Mateos, Jose Luis, Mediavilla, Roberto, Felez-Nobrega, Mireia, McGreevy, Kerry R, Monistrol-Mula, Anna, Bravo-Ortiz, María-Fe, Bayón, Carmen, Giné-Vázquez, Iago, Villaescusa, Rut, Muñoz-Sanjosé, Ainoa, Aguilar-Ortiz, Salvatore, Figueiredo, Natasha, Nicaise, Pablo, Park, A-La, Petri-Romão, Papoula, Purgato, Marianna, Witteveen, Anke B, Underhill, James, Barbui, Corrado, Bryant, Richard, Kalisch, Raffael, Lorant, Vincent, McDaid, David, Melchior, Maria, Sijbrandij, Marit, Haro, Josep Maria, and Ayuso-Mateos, Jose Luis

Abstract

BACKGROUND: Evidence-based mental health interventions to support healthcare workers (HCWs) in crisis settings are scarce. OBJECTIVE: To evaluate the capacity of a mental health intervention in reducing anxiety and depression symptoms in HCWs, relative to enhanced care as usual (eCAU), amidst the COVID-19 pandemic. METHODS: We conducted an analyst-blind, parallel, multicentre, randomised controlled trial. We recruited HCWs with psychological distress from Madrid and Catalonia (Spain). The intervention arm received a stepped-care programme consisting of two WHO-developed interventions adapted for HCWs: Doing What Matters in Times of Stress (DWM) and Problem Management Plus (PM+). Each intervention lasted 5 weeks and was delivered remotely by non-specialist mental health providers. HCWs reporting psychological distress after DWM completion were invited to continue to PM+. The primary endpoint was self-reported anxiety/depression symptoms (Patient Health Questionnaire-Anxiety and Depression Scale) at week 21. FINDINGS: Between 3 November 2021 and 31 March 2022, 115 participants were randomised to stepped care and 117 to eCAU (86% women, mean age 37.5). The intervention showed a greater decrease in anxiety/depression symptoms compared with eCAU at the primary endpoint (baseline-adjusted difference 4.4, 95% CI 2.1 to 6.7; standardised effect size 0.8, 95% CI 0.4 to 1.2). No serious adverse events occurred. CONCLUSIONS: Brief stepped-care psychological interventions reduce anxiety and depression during a period of stress among HCWs. CLINICAL IMPLICATIONS: Our results can inform policies and actions to protect the mental health of HCWs during major health crises and are potentially rapidly replicable in other settings where workers are affected by global emergencies. TRIAL REGISTRATION NUMBER: NCT04980326.

38. Development of a common scale for measuring healthy ageing across the world: results from the ATHLOS consortium.

Author

Sanchez-Niubo A, Forero CG, Wu YT, Giné-Vázquez I, Prina M, De La Fuente J, Daskalopoulou C, Critselis E, De La Torre-Luque A, Panagiotakos D, Arndt H, Ayuso-Mateos JL, Bayes-Marin I, Bickenbach J, Bobak M, Caballero FF, Chatterji S, Egea-Cortés L, García-Esquinas E, Leonardi M, Koskinen S, Koupil I, Mellor-Marsá B, Olaya B, Pająk A, Prince M, Raggi A, Rodríguez-Artalejo F, Sanderson W, Scherbov S, Tamosiunas A, Tobias-Adamczyk B, Tyrovolas S, and Haro JM

Subjects
Aging, Cohort Studies, Health Status, Humans, Reproducibility of Results, Healthy Aging
Abstract

Background: Research efforts to measure the concept of healthy ageing have been diverse and limited to specific populations. This diversity limits the potential to compare healthy ageing across countries and/or populations. In this study, we developed a novel measurement scale of healthy ageing using worldwide cohorts., Methods: In the Ageing Trajectories of Health-Longitudinal Opportunities and Synergies (ATHLOS) project, data from 16 international cohorts were harmonized. Using ATHLOS data, an item response theory (IRT) model was used to develop a scale with 41 items related to health and functioning. Measurement heterogeneity due to intra-dataset specificities was detected, applying differential item functioning via a logistic regression framework. The model accounted for specificities in model parameters by introducing cohort-specific parameters that rescaled scores to the main scale, using an equating procedure. Final scores were estimated for all individuals and converted to T-scores with a mean of 50 and a standard deviation of 10., Results: A common scale was created for 343 915 individuals above 18 years of age from 16 studies. The scale showed solid evidence of concurrent validity regarding various sociodemographic, life and health factors, and convergent validity with healthy life expectancy (r = 0.81) and gross domestic product (r = 0.58). Survival curves showed that the scale could also be predictive of mortality., Conclusions: The ATHLOS scale, due to its reliability and global representativeness, has the potential to contribute to worldwide research on healthy ageing., (© The Author(s) 2020. Published by Oxford University Press on behalf of the International Epidemiological Association.)

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results