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16 results on '"Gimenéz‐Arnau, Elena"'

2. Recomendaciones del Grupo Español de Investigación en Dermatitis de Contacto y Alergia Cutánea (GEIDAC) de la AEDV en relación con la realización de pruebas epicutáneas durante la pandemia por SARS-CoV-2 (COVID-19)

Author

Armario Hita, José Carlos, Borrego Hernando, Leopoldo, Carrascosa Carrillo, José Manuel, Córdoba Guijarro, Susana, Curto, Laia, Fernández Redondo, Virginia, Figueras Nart, Ignasi, García Gavín, Juan, Elena Gatica Ortega, María, Giménez Arnau, Anna, Giménez Arnau, Elena, Gómez de la Fuente, Enrique, González Pérez, Ricardo, Heras Mendaza, Felipe, Hervella Garcés, Marcos, Manrique Martínez, Pilar, Mercader García, Pedro, Javier Ortiz de Frutos, Francisco, Miquel Miquel, Javier, Antonia Pastor Nieto, María, Rodríguez Serna, Mercedes, Ruíz González, Inmaculada, Sánchez Gilo, Araceli, Sánchez-Pedreño Guillén, Paloma, Sánchez Pérez, Javier, Sanz Sánchez, Tatiana, Serra-Baldrich, Esther, Silvestre Salvador, Juan Francisco, Zaragoza Ninet, Violeta, Carrascosa, J.M., Pastor-Nieto, M.A., Ruiz-González, I., Silvestre, J.F., Borrego, L., Gatica-Ortega, M.E., and Giménez-Arnau, A.M.

Published
2020
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13. Is it possible to assess the allergenicity of mixtures based on in chemico methods? Preliminary results on common fragrance aldehydes

Author

Lang, Matthieu, Gimenéz Arnau, Elena, Lepoittevin, Jean-Pierre, Institut de Chimie de Strasbourg, Centre National de la Recherche Scientifique (CNRS)-Université Louis Pasteur - Strasbourg I-Institut de Chimie du CNRS (INC), Laboratoire de Chimie Quantique, Centre National de la Recherche Scientifique (CNRS), and Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[CHIM.ORGA]Chemical Sciences/Organic chemistry
Published
2016

14. An immune response study of oakmoss absolute and its constituents atranol and chloroatranol

Author

Bonefeld, Charlotte Menné, Nielsen, Morten Milek, Gimenéz-Arnau, Elena, Lang, Matthieu, Vennegaard, Marie Torp, Geisler, Carsten, Johansen, Jeanne Duus, Lepoittevin, Jean-Pierre, Bonefeld, Charlotte Menné, Nielsen, Morten Milek, Gimenéz-Arnau, Elena, Lang, Matthieu, Vennegaard, Marie Torp, Geisler, Carsten, Johansen, Jeanne Duus, and Lepoittevin, Jean-Pierre

Abstract

BACKGROUND: Atranol and chloroatranol are the main allergens of oakmoss absolute. However, the immune responses induced by these substances are poorly characterized.OBJECTIVES: To characterize immune responses induced by atranol, chloroatranol and oakmoss absolute in mice.METHODS: Mice were sensitized and challenged with various concentrations of atranol, chloroatranol, and oakmoss absolute. The immune responses were analysed as B cell infiltration, T cell proliferation in the draining lymph nodes, and expression of interleukin (IL)-18, IL-1β and tumour necrosis factor-α in skin. The cytotoxicity of atranol and chloroatranol against keratinocytes was determined.RESULTS: Sensitization experiments showed that atranol, chloroatranol and oakmoss induced sensitization when applied in high concentrations. Challenge experiments showed that even low concentrations of atranol and chloroatranol induced sensitization. In parallel, atranol and chloroatranol elicited challenge reactions following sensitization with oakmoss. The magnitude of the immune response to the three allergens increased in the following order: atranol, chloroatranol, and oakmoss. The expression of proinflammatory cytokines was induced by chloroatranol and oakmoss, but not by atranol. Chloroatranol was found to be more cytotoxic than atranol against keratinocytes.CONCLUSIONS: Atranol and chloroatranol can elicit both sensitization and challenge reactions, but the mixture of allergens in oakmoss absolute is more potent than atranol and chloroatranol alone.

Published
2014

16. An immune response study of oakmoss absolute and its constituents atranol and chloroatranol.

Author

Bonefeld CM, Nielsen MM, Gimenéz-Arnau E, Lang M, Vennegaard MT, Geisler C, Johansen JD, and Lepoittevin JP

Subjects
Animals, Antigens, CD19 immunology, B-Lymphocytes immunology, CD4-Positive T-Lymphocytes immunology, CD8-Positive T-Lymphocytes immunology, Cell Line, Cell Proliferation, Interleukin-18 immunology, Interleukin-1beta immunology, Keratinocytes, Mice, Mice, Inbred CBA, Patch Tests, Tumor Necrosis Factor-alpha immunology, Benzaldehydes immunology, Dermatitis, Allergic Contact immunology, Resins, Plant chemistry, Terpenes chemistry, Terpenes immunology
Abstract

Background: Atranol and chloroatranol are the main allergens of oakmoss absolute. However, the immune responses induced by these substances are poorly characterized., Objectives: To characterize immune responses induced by atranol, chloroatranol and oakmoss absolute in mice., Methods: Mice were sensitized and challenged with various concentrations of atranol, chloroatranol, and oakmoss absolute. The immune responses were analysed as B cell infiltration, T cell proliferation in the draining lymph nodes, and expression of interleukin (IL)-18, IL-1β and tumour necrosis factor-α in skin. The cytotoxicity of atranol and chloroatranol against keratinocytes was determined., Results: Sensitization experiments showed that atranol, chloroatranol and oakmoss induced sensitization when applied in high concentrations. Challenge experiments showed that even low concentrations of atranol and chloroatranol induced sensitization. In parallel, atranol and chloroatranol elicited challenge reactions following sensitization with oakmoss. The magnitude of the immune response to the three allergens increased in the following order: atranol, chloroatranol, and oakmoss. The expression of proinflammatory cytokines was induced by chloroatranol and oakmoss, but not by atranol. Chloroatranol was found to be more cytotoxic than atranol against keratinocytes., Conclusions: Atranol and chloroatranol can elicit both sensitization and challenge reactions, but the mixture of allergens in oakmoss absolute is more potent than atranol and chloroatranol alone., (© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

Published
2014
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