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3. Longitudinal Characterization of Phagocytic and Neutralization Functions of Anti-Spike Antibodies in Plasma of Patients after Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Author

Adhikari, Anurag, primary, Abayasingam, Arunasingam, additional, Rodrigo, Chaturaka, additional, Agapiou, David, additional, Pandzic, Elvis, additional, Brasher, Nicholas A., additional, Fernando, Bentotage Samitha Madushan, additional, Keoshkerian, Elizabeth, additional, Li, Hui, additional, Kim, Ha Na, additional, Lord, Megan, additional, Popovic, Gordona, additional, Rawlinson, William, additional, Mina, Michael, additional, Post, Jeffrey J., additional, Hudson, Bernard, additional, Gilroy, Nicky, additional, Dwyer, Dominic, additional, Sasson, Sarah C., additional, Grubor-Bauk, Branka, additional, Lloyd, Andrew R., additional, Martinello, Marianne, additional, Bull, Rowena A., additional, and Tedla, Nicodemus, additional

Published
2022
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5. Resistance Mutations in SARS-CoV-2 Delta Variant after Sotrovimab Use

Author

Rockett, Rebecca, primary, Basile, Kerri, additional, Maddocks, Susan, additional, Fong, Winkie, additional, Agius, Jessica E., additional, Johnson-Mackinnon, Jessica, additional, Arnott, Alicia, additional, Chandra, Shona, additional, Gall, Mailie, additional, Draper, Jenny, additional, Martinez, Elena, additional, Sim, Eby M., additional, Lee, Clement, additional, Ngo, Christine, additional, Ramsperger, Marc, additional, Ginn, Andrew N., additional, Wang, Qinning, additional, Fennell, Michael, additional, Ko, Danny, additional, Lim, H. Ling, additional, Gilroy, Nicky, additional, O’Sullivan, Matthew V.N., additional, Chen, Sharon C.-A., additional, Kok, Jen, additional, Dwyer, Dominic E., additional, and Sintchenko, Vitali, additional

Published
2022
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6. Clinical care of pregnant and postpartum women with COVID‐19: Living recommendations from the National COVID‐19 Clinical Evidence Taskforce

Author

Vogel, Joshua P., Tendal, Britta, Giles, Michelle, Whitehead, Clare, Burton, Wendy, Chakraborty, Samantha, Cheyne, Saskia, Downton, Teena, Fraile Navarro, David, Gleeson, Glenda, Gordon, Adrienne, Hunt, Jenny, Kitschke, Jackie, McDonald, Steven, McDonnell, Nolan, Middleton, Philippa, Millard, Tanya, Murano, Melissa, Oats, Jeremy, Tate, Rhiannon, White, Heath, Elliott, Julian, Roach, Vijay, Homer, Caroline S.E., McGowan, Sharon, Ballenden, Nicola, Barrett, Terri‐Lee, Beavis, Vanessa, Saunders, James Beckford, Buchanan, Tanya, Buchanan‐Grey, Marina, Casey, Dawn, Cowie, Marita, Doyle, Joseph, Frydenberg, Mark, Gnjidic, Danijela, Green, Sally, Greenland, Rohan, Griffin, Ken, Groombridge, Stephan, Hardy, Louise, Hodak, Alison, Holley, Anthony, Jovanovska, Vase, Knight, Sabina, Michaels, Kristin, Morley, Peter, Morphet, Julia, Nou, Suzi, Russo, Phillip, Sarson, Megan, Young, Alan, Norris, Sarah, Morris‐Donovan, Bronwyn, Gurry, Sharon, Hudson, Eloise, Hurley, Shauna, Primmer, Declan, Timms, Samantha, Whicker, Susan, Mukherjee, Sutapa, Agostino, Jason, Booth, Karen, Burr, Lucy, Byers, Lyn, Cameron, Peter, Cooper, Megan, Cheng, Allen, Fowler, Peter, Glanville, Alan, Leder, Karin, McGloughlin, Steve, McMullan, Brendan, McPhee, Ewen, Mitchell, Brett, Morgan, Mark, Myles, Paul, O’Donnell, Chris, Parr, Michael, Phillips, Jane, Randall, Rebecca, Varndell, Wayne, Whyte, Ian, William, Leeroy, Brightwell, Richard, Condon, Lynda, Deshpande, Amrita, Ehm, Adam, Ferrie, Monica, Muller, Joanne, Pullin, Lara, Robinson, Elizabeth, Witt, Adele, Larkins, Sarah, Taylor, Georgina, Burgess, Paul, Burns, Penny, Douglas, Kirsty, Ewald, Ben, Ewald, Dan, Fornasier, Dianna, Nelson, Carmel, Peachey, Louis, Peiris, David, Driel, Mieke, Walters, Lucie, Weaver, Ineke, Hendel, Simon, Shekar, Kiran, Avard, Bronwyn, Cairns, Kelly, Glanville, Allan, Gilroy, Nicky, O’Sullivan, Robert, Robinson, Owen, Sharland, Chantal, McCarthy, Sally, Wark, Peter, McGoughlin, Steve, Nair, Priya, Hodgson, Carol, Ankravs, Melissa, French, Craig, Hansen, Kim, Huckson, Sue, Iredell, Jon, Janerka, Carrie, Jaspers, Rose, Litton, Ed, Macdonald, Stephen, Peake, Sandra, Seppelt, Ian, Bowen, Asha, Tingay, David, Vasilunas, Nan, Anderson, Lorraine, Best, James, Craig, Simon, Erickson, Simon, Fancourt, Nick, Goff, Zoy, Kapuya, Vimbai, Keyte, Catherine, Malyon, Lorelle, Wurzel, Danielle, Agar, Meera, Lindley, Richard, Smallwood, Natasha, Callary, Mandy, Chapman, Michael, Good, Philip, Jenkin, Peter, Morgan, Deidre, Naganathan, Vasi, Srikanth, Velandai, Tuffin, Penny, Whiting, Elizabeth, Yates, Patsy, Barber, Bridget, Davies, Jane, Davis, Josh, Gwee, Amanda, Matthews, Gail, McMahon, James, Peel, Trisha, Raftery, Chris, Rees, Megan, Roberts, Jason, Snelling, Tom, Wibrow, Brad, Baker, Ross, Curnow, Jennifer, Cutts, Briony, Enjeti, Anoop, Forbes, Andrew, Ho, Prahlad, Holyoak, Adam, Liley, Helen, McFadyen, James, McQuilten, Zoe, Merriman, Eileen, Savoia, Helen, Tan, Chee Wee, Tran, Huyen, Ward, Chris, Williams, Katrina, Ballard, Neil, Bendall, Samantha, Bhanderi, Neel, Ellis, Dan, Fairley, Craig, Hoggard, Brett, Cong, Minh Le, Pearce, Andrew, Turner, Tari, Callesen, Henriette, Campbell, Sue, Ring, Jenny, Wilson, Agnes, Henry, David, Pearson, Sallie, Boyle, Douglas, Chidwick, Kendal, Chapman, Wendy, Pearce, Chris, Bero, Lisa, Grundy, Quinn, Lexchin, Joel, and Mintzes, Barbara

Subjects
medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), medicine.medical_treatment, Breastfeeding, Psychological intervention, Prenatal care, 03 medical and health sciences, 0302 clinical medicine, COVID‐19, Pregnancy, Obstetrics and Gynaecology, medicine, Extracorporeal membrane oxygenation, Humans, 030212 general & internal medicine, guidelines, Pregnancy Complications, Infectious, Intensive care medicine, 030219 obstetrics & reproductive medicine, business.industry, SARS-CoV-2, Postpartum Period, Australia, Obstetrics and Gynecology, COVID-19, Hydroxychloroquine, perinatal care, Prenatal Care, General Medicine, medicine.disease, Female, Position Paper, business, Position Papers, Postpartum period, medicine.drug
Abstract

To date, 18 living recommendations for the clinical care of pregnant and postpartum women with COVID-19 have been issued by the National COVID-19 Clinical Evidence Taskforce. This includes recommendations on mode of birth, delayed umbilical cord clamping, skin-to-skin contact, breastfeeding, rooming-in, antenatal corticosteroids, angiotensin-converting enzyme inhibitors, disease-modifying treatments (including dexamethasone, remdesivir and hydroxychloroquine), venous thromboembolism prophylaxis and advanced respiratory support interventions (prone positioning and extracorporeal membrane oxygenation). Through continuous evidence surveillance, these living recommendations are updated in near real-time to ensure clinicians in Australia have reliable, evidence-based guidelines for clinical decision-making. Please visit https://covid19evidence.net.au/ for the latest recommendation updates.

Published
2020

7. Maintenance of broad neutralizing antibodies and memory B cells 1 year post-infection is predicted by SARS-CoV-2-specific CD4+ T cell responses

Author

Balachandran, Harikrishnan, Phetsouphanh, Chansavath, Agapiou, David, Adhikari, Anurag, Rodrigo, Chaturaka, Hammoud, Mohamed, Shrestha, Lok Bahadur, Keoshkerian, Elizabeth, Gupta, Money, Turville, Stuart, Christ, Daniel, King, Cecile, Sasson, Sarah C., Bartlett, Adam, Grubor-Bauk, Branka, Rawlinson, William, Aggarwal, Anupriya, Stella, Alberto Ospina, Klemm, Vera, Mina, Michael M., Post, Jeffrey J., Hudson, Bernard, Gilroy, Nicky, Konecny, Pam, Ahlenstiel, Golo, Dwyer, Dominic E., Sorrell, Tania C., Kelleher, Anthony, Tedla, Nicodemus, Lloyd, Andrew R., Martinello, Marianne, Bull, Rowena A., and Group, COSIN Study

Subjects
Adult, CD4-Positive T-Lymphocytes, Male, Delta variant, QH301-705.5, SARS-CoV-2 OX40 CD4 T cell assay, Antibodies, Viral, variants of concern, Severity of Illness Index, Article, General Biochemistry, Genetics and Molecular Biology, protection efficacy prediction, Cohort Studies, Memory B Cells, Humans, Biology (General), SARS-CoV-2, Australia, Immunity, RBD-specific memory B cells longevity, COVID-19, SARS-CoV-2 antibody duration, Antibodies, Neutralizing, 12 months after SARS-CoV-2 infection, Immunity, Humoral, Coronavirus, SARS-CoV-2 neutralization, Spike Glycoprotein, Coronavirus, Female, Broadly Neutralizing Antibodies
Abstract

Understanding the long-term maintenance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity is critical for predicting protection against reinfection. In an age- and gender-matched cohort of 24 participants, the association of disease severity and early immune responses on the maintenance of humoral immunity 12 months post-infection is examined. All severely affected participants maintain a stable subset of SARS-CoV-2 receptor-binding domain (RBD)-specific memory B cells (MBCs) and good neutralizing antibody breadth against the majority of the variants of concern, including the Delta variant. Modeling these immune responses against vaccine efficacy data indicate a 45%–76% protection against symptomatic infection (variant dependent). Overall, these findings indicate durable humoral responses in most participants after infection, reasonable protection against reinfection, and implicate baseline antigen-specific CD4+ T cell responses as a predictor of maintenance of antibody neutralization breadth and RBD-specific MBC levels at 12 months post-infection., Graphical abstract, One year after SARS-CoV-2 infection, despite declining antibody titers, Balachandran et al. report a disease-severity-associated maintenance of antibody functions and memory B cell magnitudes. The convalescent serum could neutralize most VOCs, and the initial CD4 T cell levels predict the antibody neutralization breadth and memory B cell durability.

Published
2022

8. Maintenance of broad neutralizing antibodies and memory B cells 1 year post-infection is predicted by SARS-CoV-2-specific CD4+ T cell responses

Author

Balachandran, Harikrishnan, primary, Phetsouphanh, Chansavath, additional, Agapiou, David, additional, Adhikari, Anurag, additional, Rodrigo, Chaturaka, additional, Hammoud, Mohamed, additional, Shrestha, Lok Bahadur, additional, Keoshkerian, Elizabeth, additional, Gupta, Money, additional, Turville, Stuart, additional, Christ, Daniel, additional, King, Cecile, additional, Sasson, Sarah C., additional, Bartlett, Adam, additional, Grubor-Bauk, Branka, additional, Rawlinson, William, additional, Aggarwal, Anupriya, additional, Stella, Alberto Ospina, additional, Klemm, Vera, additional, Mina, Michael M., additional, Post, Jeffrey J., additional, Hudson, Bernard, additional, Gilroy, Nicky, additional, Konecny, Pam, additional, Ahlenstiel, Golo, additional, Dwyer, Dominic E., additional, Sorrell, Tania C., additional, Kelleher, Anthony, additional, Tedla, Nicodemus, additional, Lloyd, Andrew R., additional, Martinello, Marianne, additional, and Bull, Rowena A., additional

Published
2022
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9. RESISTANCE CONFERRING MUTATIONS IN SARS-CoV-2 DELTA FOLLOWING SOTROVIMAB INFUSION

Author

Rockett, Rebecca J, primary, Basile, Kerri, additional, Maddocks, Susan, additional, Fong, Winkie, additional, Agius, Jessica E, additional, Mackinnon, Jessica Johnson, additional, Arnott, Alicia, additional, Chandra, Shona, additional, Gall, Mailie, additional, Draper, Jenny, additional, Martinez, Elena, additional, Sim, Eby M, additional, Lee, Clement, additional, Ngo, Christine, additional, Ramsperger, Marc, additional, Ginn, Andrew N, additional, Wang, Qinning, additional, Fennell, Michael, additional, Ko, Danny, additional, Lim, H Ling, additional, Gilroy, Nicky, additional, O’Sullivan, Matthew V N, additional, Chen, Sharon C-A, additional, Kok, Jen, additional, Dwyer, Dominic E, additional, and Sintchenko, Vitali, additional

Published
2021
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10. Diabetes and hyperglycaemia among hospitalised patients with COVID‐19 in Western Sydney: a retrospective cohort study.

Author

Cheung, N. Wah, Gilroy, Nicky, Hor, Amanda, Jose, Suja, Kairaitis, Kristina, Nayyar, Vineet, O'Sullivan, Matthew V. N., Wheatley, John, and Chipps, David R.

Subjects
*DIABETES complications, *GLYCOSYLATED hemoglobin, *INTENSIVE care units, *LENGTH of stay in hospitals, *COVID-19, *HYPERGLYCEMIA, *MULTIVARIATE analysis, *RETROSPECTIVE studies, *ACQUISITION of data, *BLOOD sugar, *PATIENTS, *TREATMENT effectiveness, *HOSPITAL admission & discharge, *HOSPITAL care, *MEDICAL records, *DESCRIPTIVE statistics, *LONGITUDINAL method, *DISEASE complications, *EVALUATION
Abstract

Background: Diabetes has been recognised as a major risk factor for COVID‐19 mortality and hospital complications in earlier studies. Aims: To examine the characteristics of hospitalised COVID‐19 patients with diabetes and the impact of diabetes and hyperglycaemia on hospital outcomes. Methods: This was a retrospective cohort study. Admission glucose levels, HbA1c, diabetes status and hospital outcomes were determined for subjects admitted from June to November 2021 by matching a pathology data set, a clinical data set and the hospital administrative database. The outcomes of interest were death, intensive care unit (ICU) admission and length of stay (LOS). Results: There were 1515 individuals admitted with COVID‐19 with 49 deaths (3.2%) and 205 (13.5%) ICU admissions. The median length of hospital stay was 3.7 days. Three hundred and ten patients (20%) had diabetes, with 46 (15%) newly diagnosed. Patients with diabetes had a higher mortality than patients who did not have diabetes (8% vs 2%, P < 0.001), were more likely to be admitted to ICU (20% vs 12%, P = 0.001) and have longer median LOS stay (6.6 (interquartile range (IQR) 2.9–12.5) vs 2.9 (IQR 0.5–7.1) days, P < 0.001). In multivariate models, neither diabetes nor admission glucose predicted death. Admission glucose level but not diabetes was an independent predictor of ICU admission and LOS. Conclusions: There is a high prevalence of diabetes among patients hospitalised with COVID‐19, with worse outcomes. In contrast to previous studies, the association of diabetes with mortality was not significant when adjusted for other variables. This is possibly related to the benefits of vaccination and current medical and ICU interventions. [ABSTRACT FROM AUTHOR]

Published
2023
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11. High activation levels maintained in receptor‐binding domain–specific memory B cells in people with severe coronavirus disease 2019.

Author

Gupta, Money, Balachandran, Harikrishnan, Louie, Raymond H Y, Li, Hui, Agapiou, David, Keoshkerian, Elizabeth, Christ, Daniel, Rawlinson, William, Mina, Michael M, Post, Jeffrey J, Hudson, Bernard, Gilroy, Nicky, Konecny, Pamela, Bartlett, Adam W, Sasson, Sarah C, Ahlenstiel, Golo, Dwyer, Dominic, Lloyd, Andrew R, Martinello, Marianne, and Luciani, Fabio

Subjects
B cells, SARS-CoV-2, COVID-19, IMMUNOLOGIC memory, TUMOR necrosis factors, NF-kappa B
Abstract

The long‐term health consequences of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection are still being understood. The molecular and phenotypic properties of SARS‐CoV‐2 antigen–specific T cells suggest a dysfunctional profile that persists in convalescence in those who were severely ill. By contrast, the antigen‐specific memory B‐cell (MBC) population has not yet been analyzed to the same degree, but phenotypic analysis suggests differences following recovery from mild or severe coronavirus disease 2019 (COVID‐19). Here, we performed single‐cell molecular analysis of the SARS‐CoV‐2 receptor‐binding domain (RBD)–specific MBC population in three patients after severe COVID‐19 and four patients after mild/moderate COVID‐19. We analyzed the transcriptomic and B‐cell receptor repertoire profiles at ~2 months and ~4 months after symptom onset. Transcriptomic analysis revealed a higher level of tumor necrosis factor‐alpha (TNF‐α) signaling via nuclear factor‐kappa B in the severe group, involving CD80, FOS, CD83 and TNFAIP3 genes that was maintained over time. We demonstrated the presence of two distinct activated MBCs subsets based on expression of CD80hiTNFAIP3hi and CD11chiCD95hi at the transcriptome level. Both groups revealed an increase in somatic hypermutation over time, indicating progressive evolution of humoral memory. This study revealed distinct molecular signatures of long‐term RBD‐specific MBCs in convalescence, indicating that the longevity of these cells may differ depending on acute COVID‐19 severity. [ABSTRACT FROM AUTHOR]

Published
2023
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12. Long-term persistence of RBD+ memory B cells encoding neutralizing antibodies in SARS-CoV-2 infection

Author

Abayasingam, Arunasingam, Balachandran, Harikrishnan, Agapiou, David, Hammoud, Mohamed, Rodrigo, Chaturaka, Keoshkerian, Elizabeth, Li, Hui, Brasher, Nicholas A., Christ, Daniel, Rouet, Romain, Burnet, Deborah, Grubor-Bauk, Branka, Rawlinson, William, Turville, Stuart, Aggarwal, Anupriya, Stella, Alberto Ospina, Fichter, Christina, Brilot, Fabienne, Mina, Michael, Post, Jeffrey J., Hudson, Bernard, Gilroy, Nicky, Dwyer, Dominic, Sasson, Sarah C., Tea, Fiona, Pilli, Deepti, Kelleher, Anthony, Tedla, Nicodemus, Lloyd, Andrew R., Martinello, Marianne, and Bull, Rowena A.

Published
2021
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13. An emergent clade of SARS-CoV-2 linked to returned travellers from Iran

Author

Eden, John-Sebastian, Rockett, Rebecca, Carter, Ian, Rahman, Hossinur, de Ligt, Joep, Hadfield, James, Storey, Matthew, Ren, Xiaoyun, Tulloch, Rachel, Basile, Kerri, Wells, Jessica, Byun, Roy, Gilroy, Nicky, O’Sullivan, Matthew V, Sintchenko, Vitali, Chen, Sharon C, Maddocks, Susan, Sorrell, Tania C, Holmes, Edward C, Dwyer, Dominic E, Kok, Jen, Donovan, Linda, Kumar, Shanil, Tran, Tyna, Ko, Danny, Ngo, Christine, Sivaruban, Tharshini, Timms, Verlaine, Lam, Connie, Gall, Mailie, Gray, Karen-Ann, Sadsad, Rosemarie, and Arnott, Alicia

Subjects
2019-20 coronavirus outbreak, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Sequencing data, Biology, Microbiology, DNA sequencing, 03 medical and health sciences, 0302 clinical medicine, Virology, 030212 general & internal medicine, China, Socioeconomics, Clade, 030304 developmental biology, Whole genome sequencing, 0303 health sciences, Phylogenetic tree, SARS-CoV-2, Outbreak, COVID-19, 3. Good health, genome sequencing, phylogenetics, Coronavirus, Geography, Evolutionary biology, Rapid Communication
Abstract

The SARS-CoV-2 epidemic has rapidly spread outside China with major outbreaks occurring in Italy, South Korea, and Iran. Phylogenetic analyses of whole-genome sequencing data identified a distinct SARS-CoV-2 clade linked to travellers returning from Iran to Australia and New Zealand. This study highlights potential viral diversity driving the epidemic in Iran, and underscores the power of rapid genome sequencing and public data sharing to improve the detection and management of emerging infectious diseases.

Published
2020

14. Maintenance of Broad Neutralising Antibodies and Memory B Cells 12 Months Post-Infection Is Predicted by SARS-CoV-2 Specific CD4+ T Cell Responses

Author

Balachandran, Harikrishnan, primary, Phetsouphanh, Chansavath, additional, Agapiou, David, additional, Adhikari, Anurag, additional, Rodrigo, Chaturaka, additional, Hammoud, Mohamed, additional, Shrestha, Lok Bahadur, additional, Keoshkerian, Elizabeth, additional, Gupta, Money, additional, Turville, Stuart, additional, Christ, Daniel, additional, King, Cecile, additional, Sasson, Sarah, additional, Bartlett, Adam, additional, Grubor-Bauk, Branka, additional, Rawlinson, William, additional, Aggarwal, Anupriya, additional, Stella, Alberto Ospina, additional, Klemm, Vera, additional, Mina, Michael M., additional, Post, Jeffrey J., additional, Hudson, Bernard, additional, Gilroy, Nicky, additional, Konecny, Pam, additional, Ahlenstiel, Golo, additional, Dwyer, Dominic, additional, Sorrell, Tania C., additional, Kelleher, Anthony, additional, Tedla, Nicodemus, additional, Lloyd, Andrew R., additional, Martinello, Marianne, additional, and Bull, Rowena Anne, additional

Published
2021
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16. Long-term persistence of neutralizing memory B cells in SARS-CoV-2

Author

Bull, Rowena, primary, Abayasingam, Arunasingam, additional, Balachandran, Harikrishnan, additional, Agapiou, David, additional, Rodrigo, Chaturaka, additional, Keoshkerian, Elizabeth, additional, Li, Hui, additional, Brasher, Nicholas, additional, Christ, Daniel, additional, Rouet, Romain, additional, Burnett, Deborah, additional, Grubor-Bauk, Branka, additional, Rawlinson, William, additional, Turville, Stuart, additional, Aggarwal, Anupriya, additional, Brilot, Fabienne, additional, Mina, Michael, additional, Post, Jeffrey, additional, Hudson, Bernard, additional, Gilroy, Nicky, additional, Dwyer, Dominic, additional, Sasson, Sarah, additional, Tea, Fiona, additional, Pilli, Deepti, additional, Tedla, Nicodemus, additional, Lloyd, Andrew, additional, and Martinello, Marianne, additional

Published
2020
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17. Long-Term Persistence of Neutralizing Memory B Cells in SARS-CoV-2

Author

Abayasingam, Arunasingam, primary, Balachandran, Harikrishnan, additional, Agapiou, David, additional, Rodrigo, Chaturaka, additional, Keoshkerian, Elizabeth, additional, Li, Hui, additional, Brasher, Nicholas, additional, Christ, Daniel, additional, Rouet, Romain, additional, Burnett, Deborah, additional, Grubor-Bauk, Branka, additional, Rawlinson, William, additional, Turville, Stuart, additional, Aggarwal, Anupriya, additional, Brilot, Fabienne, additional, Mina, Michael, additional, Post, Jeffrey J., additional, Hudson, Bernard, additional, Gilroy, Nicky, additional, Dwyer, Dominic, additional, Sasson, Sarah, additional, Tea, Fiona, additional, Pilli, Deepti, additional, Tedla, Nicodemus, additional, Lloyd, Andrew R, additional, Martinello, Marianne, additional, Bull, Rowena Anne, additional, and Group, COSIN Study, additional

Published
2020
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18. Complementary and Alternative Medicine Therapy (CAM) Use by Allogeneic BMT Survivorship Patients

Author

Lindsay, Julian, primary, Kabir, Masrura, additional, Gilroy, Nicky, additional, Dyer, Gemma, additional, Brice, Lisa, additional, Greenwood, Matthew, additional, Moore, John, additional, Hertzberg, Mark, additional, Larsen, Stephen, additional, Kwan, John, additional, Brown, Louisa, additional, Hogg, Megan, additional, Huang, Gillian, additional, Tan, Jeff, additional, Gifford, Grace, additional, and Kerridge, Ian, additional

Published
2016
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20. Fatal Mycotic Aneurysms Due to Scedosporiumand PseudallescheriaInfection

Author

Ong, Adrian, Blyth, Christopher C., Bency, Rosamma, Vicaretti, Mauro, Harun, Azian, Meyer, Wieland, Shingde, Meena, Gilroy, Nicky, Chapman, Jeremy, and Chen, Sharon C.-A.

Abstract

ABSTRACTAngioinvasive complications of Scedosporiuminfections are rare. We report two cases of mycotic aneurysm, following apparent localized infection, due to Scedosporium apiospermumand Pseudallescheria boydii. The thoracoabdominal aorta was affected in one patient, and cerebral vessels were affected in the other. Despite voriconazole therapy and surgical resection, the patients died. Previously reported cases are reviewed.

Published
2011
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21. Long-term persistence of RBD+memory B cells encoding neutralizing antibodies in SARS-CoV-2 infection

Author

Abayasingam, Arunasingam, Balachandran, Harikrishnan, Agapiou, David, Hammoud, Mohamed, Rodrigo, Chaturaka, Keoshkerian, Elizabeth, Li, Hui, Brasher, Nicholas A., Christ, Daniel, Rouet, Romain, Burnet, Deborah, Grubor-Bauk, Branka, Rawlinson, William, Turville, Stuart, Aggarwal, Anupriya, Stella, Alberto Ospina, Fichter, Christina, Brilot, Fabienne, Mina, Michael, Post, Jeffrey J., Hudson, Bernard, Gilroy, Nicky, Dwyer, Dominic, Sasson, Sarah C., Tea, Fiona, Pilli, Deepti, Kelleher, Anthony, Tedla, Nicodemus, Lloyd, Andrew R., Martinello, Marianne, and Bull, Rowena A.

Abstract

Considerable concerns relating to the duration of protective immunity against severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) exist, with evidence of antibody titers declining rapidly after infection and reports of reinfection. Here, we monitor the antibody responses against SARS-CoV-2 receptor-binding domain (RBD) for up to 6 months after infection. While antibody titers are maintained, ∼13% of the cohort’s neutralizing responses return to background. However, encouragingly, in a selected subset of 13 participants, 12 have detectable RBD-specific memory B cells and these generally are increasing out to 6 months. Furthermore, we are able to generate monoclonal antibodies with SARS-CoV-2 neutralizing capacity from these memory B cells. Overall, our study suggests that the loss of neutralizing antibodies in plasma may be countered by the maintenance of neutralizing capacity in the memory B cell repertoire.

Published
2021
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22. An emergent clade of SARS-CoV-2 linked to returned travellers from Iran

Author

Eden, John-Sebastian, Rockett, Rebecca J, Carter, Ian, Rahman, Hossinur, de Ligt, Jeop, Hadfield, James, Storey, Matthew, Ren, Xiaoyun, Tulloch, Rachel, Basile, Kerri, Wells, Jessica, Byun, Roy, Gilroy, Nicky, O’Sullivan, Matthew V., Sintchenko, Vitali, Chen, Sharon, Maddocks, Susan, Sorrell, Tania C., C. Holmes, Edward, E. Dwyer, Dominic, and Kok, Jen

Subjects
Epigenetics (incl. genome methylation and epigenomics), Virology, Infectious diseases, Microbiology not elsewhere classified, Evolutionary biology not elsewhere classified, Genomics, Microbial genetics, 3. Good health
Abstract

The SARS-CoV-2 epidemic has rapidly spread outside China with major outbreaks occurring in Italy, South Korea, and Iran. Phylogenetic analyses of whole-genome sequencing data identified a distinct SARS-CoV-2 clade linked to travellers returning from Iran to Australia and New Zealand. This study highlights potential viral diversity driving the epidemic in Iran, and underscores the power of rapid genome sequencing and public data sharing to improve the detection and management of emerging infectious diseases.

23. An emergent clade of SARS-CoV-2 linked to returned travellers from Iran

Author

Eden, John-Sebastian, Rockett, Rebecca J, Carter, Ian, Rahman, Hossinur, de Ligt, Jeop, Hadfield, James, Storey, Matthew, Ren, Xiaoyun, Tulloch, Rachel, Basile, Kerri, Wells, Jessica, Byun, Roy, Gilroy, Nicky, O’Sullivan, Matthew V., Sintchenko, Vitali, Chen, Sharon, Maddocks, Susan, Sorrell, Tania C., C. Holmes, Edward, E. Dwyer, Dominic, and Kok, Jen

Subjects
Epigenetics (incl. genome methylation and epigenomics), Virology, Infectious diseases, Microbiology not elsewhere classified, Evolutionary biology not elsewhere classified, Genomics, Microbial genetics, 3. Good health
Abstract

The SARS-CoV-2 epidemic has rapidly spread outside China with major outbreaks occurring in Italy, South Korea, and Iran. Phylogenetic analyses of whole-genome sequencing data identified a distinct SARS-CoV-2 clade linked to travellers returning from Iran to Australia and New Zealand. This study highlights potential viral diversity driving the epidemic in Iran, and underscores the power of rapid genome sequencing and public data sharing to improve the detection and management of emerging infectious diseases.

24. An emergent clade of SARS-CoV-2 linked to returned travellers from Iran.

Author

Eden JS, Rockett R, Carter I, Rahman H, de Ligt J, Hadfield J, Storey M, Ren X, Tulloch R, Basile K, Wells J, Byun R, Gilroy N, O'Sullivan MV, Sintchenko V, Chen SC, Maddocks S, Sorrell TC, Holmes EC, Dwyer DE, and Kok J

Abstract

The SARS-CoV-2 epidemic has rapidly spread outside China with major outbreaks occurring in Italy, South Korea, and Iran. Phylogenetic analyses of whole-genome sequencing data identified a distinct SARS-CoV-2 clade linked to travellers returning from Iran to Australia and New Zealand. This study highlights potential viral diversity driving the epidemic in Iran, and underscores the power of rapid genome sequencing and public data sharing to improve the detection and management of emerging infectious diseases., (© The Author(s) 2020. Published by Oxford University Press.)

Published
2020
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