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2. Safety and anti-tumour activity of the IgE antibody MOv18 in patients with advanced solid tumours expressing folate receptor-alpha: a phase I trial

Author

Spicer, James, Basu, Bristi, Montes, Ana, Banerji, Udai, Kristeleit, Rebecca, Miller, Rowan, Veal, Gareth J., Corrigan, Christopher J., Till, Stephen J., Figini, Mariangela, Canevari, Silvana, Barton, Claire, Jones, Paul, Mellor, Sarah, Carroll, Simon, Selkirk, Chris, Nintos, George, Kwatra, Vineet, Funingana, Ionut-Gabriel, Doherty, Gary, Gould, Hannah J., Pellizzari, Giulia, Nakamura, Mano, Ilieva, Kristina M., Khiabany, Atousa, Stavraka, Chara, Chauhan, Jitesh, Gillett, Cheryl, Pinder, Sarah, Bax, Heather J., Josephs, Debra H., and Karagiannis, Sophia N.

Published
2023
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3. LYVE-1+ macrophages form a collaborative CCR5-dependent perivascular niche that influences chemotherapy responses in murine breast cancer

Author

Anstee, Joanne E., Feehan, Karen T., Opzoomer, James W., Dean, Isaac, Muller, Henrike P., Bahri, Meriem, Cheung, Tik Shing, Liakath-Ali, Kifayathullah, Liu, Ziyan, Choy, Desmond, Caron, Jonathan, Sosnowska, Dominika, Beatson, Richard, Muliaditan, Tamara, An, Zhengwen, Gillett, Cheryl E., Lan, Guocheng, Zou, Xiangang, Watt, Fiona M., Ng, Tony, Burchell, Joy M., Kordasti, Shahram, Withers, David R., Lawrence, Toby, and Arnold, James N.

Published
2023
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4. Folate receptor alpha in ovarian cancer tissue and patient serum is associated with disease burden and treatment outcomes

Author

Bax, Heather J., Chauhan, Jitesh, Stavraka, Chara, Santaolalla, Aida, Osborn, Gabriel, Khiabany, Atousa, Grandits, Melanie, López-Abente, Jacobo, Palhares, Lais C. G. F., Chan Wah Hak, Charleen, Robinson, Alexandra, Pope, Amy, Woodman, Natalie, Naceur-Lombardelli, Cristina, Malas, Sadek, Coumbe, Jack E. M., Nakamura, Mano, Laddach, Roman, Mele, Silvia, Crescioli, Silvia, Black, Anna M., Lombardi, Sara, Canevari, Silvana, Figini, Mariangela, Sayasneh, Ahmad, Tsoka, Sophia, FitzGerald, Kevin, Gillett, Cheryl, Pinder, Sarah, Van Hemelrijck, Mieke, Kristeleit, Rebecca, Ghosh, Sharmistha, Montes, Ana, Spicer, James, Karagiannis, Sophia N., and Josephs, Debra H.

Published
2023
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6. Development of a deep‐learning model tailored for HER2 detection in breast cancer to aid pathologists in interpreting HER2‐low cases.

Author

Bannier, Pierre‐Antoine, Broeckx, Glenn, Herpin, Loïc, Dubois, Rémy, Van Praet, Lydwine, Maussion, Charles, Deman, Frederik, Amonoo, Ellen, Mera, Anca, Timbres, Jasmine, Gillett, Cheryl, Sawyer, Elinor, Gazińska, Patrycja, Ziolkowski, Piotr, Lacroix‐Triki, Magali, Salgado, Roberto, and Irshad, Sheeba

Subjects
FLUORESCENCE in situ hybridization, BREAST cancer, DEEP learning, ARTIFICIAL intelligence, LYMPHOCYTE count, BREAST
Abstract

Aims: Over 50% of breast cancer cases are "Human epidermal growth factor receptor 2 (HER2) low breast cancer (BC)", characterized by HER2 immunohistochemistry (IHC) scores of 1+ or 2+ alongside no amplification on fluorescence in situ hybridization (FISH) testing. The development of new anti‐HER2 antibody‐drug conjugates (ADCs) for treating HER2‐low breast cancers illustrates the importance of accurately assessing HER2 status, particularly HER2‐low breast cancer. In this study we evaluated the performance of a deep‐learning (DL) model for the assessment of HER2, including an assessment of the causes of discordances of HER2‐Null between a pathologist and the DL model. We specifically focussed on aligning the DL model rules with the ASCO/CAP guidelines, including stained cells' staining intensity and completeness of membrane staining. Methods and Results: We trained a DL model on a multicentric cohort of breast cancer cases with HER2‐IHC scores (n = 299). The model was validated on two independent multicentric validation cohorts (n = 369 and n = 92), with all cases reviewed by three senior breast pathologists. All cases underwent a thorough review by three senior breast pathologists, with the ground truth determined by a majority consensus on the final HER2 score among the pathologists. In total, 760 breast cancer cases were utilized throughout the training and validation phases of the study. The model's concordance with the ground truth (ICC = 0.77 [0.68–0.83]; Fisher P = 1.32e‐10) is higher than the average agreement among the three senior pathologists (ICC = 0.45 [0.17–0.65]; Fisher P = 2e‐3). In the two validation cohorts, the DL model identifies 95% [93% ‐ 98%] and 97% [91% ‐ 100%] of HER2‐low and HER2‐positive tumours, respectively. Discordant results were characterized by morphological features such as extended fibrosis, a high number of tumour‐infiltrating lymphocytes, and necrosis, whilst some artefacts such as nonspecific background cytoplasmic stain in the cytoplasm of tumour cells also cause discrepancy. Conclusion: Deep learning can support pathologists' interpretation of difficult HER2‐low cases. Morphological variables and some specific artefacts can cause discrepant HER2‐scores between the pathologist and the DL model. [ABSTRACT FROM AUTHOR]

Published
2024
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8. A cohort profile of the Graham Roberts study cohort

Author

Russell, Beth, primary, Leech, Poppy, additional, Wylie, Harriet, additional, Moss, Charlotte Louise, additional, Haire, Anna, additional, Enting, Deborah, additional, Amery, Suzanne, additional, Chatterton, Kathryn, additional, Khan, Muhammad Shamim, additional, Thurairaja, Ramesh, additional, Nair, Rajesh, additional, Malde, Sachin, additional, Smith, Kate, additional, Gillett, Cheryl, additional, Josephs, Debra, additional, Pintus, Elias, additional, Rudman, Sarah, additional, Hughes, Simon, additional, Relton, Clare, additional, and Van Hemelrijck, Mieke, additional

Published
2024
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10. Genomic Complexity Profiling Reveals That HORMAD1 Overexpression Contributes to Homologous Recombination Deficiency in Triple-Negative Breast Cancers

Author

Watkins, Johnathan, Weekes, Daniel, Shah, Vandna, Gazinska, Patrycja, Joshi, Shalaka, Sidhu, Bhavna, Gillett, Cheryl, Pinder, Sarah, Vanoli, Fabio, Jasin, Maria, Mayrhofer, Markus, Isaksson, Anders, Cheang, Maggie CU, Mirza, Hasan, Frankum, Jessica, Lord, Christopher J, Ashworth, Alan, Vinayak, Shaveta, Ford, James M, Telli, Melinda L, Grigoriadis, Anita, and Tutt, Andrew NJ

Subjects
Human Genome, Cancer, Biotechnology, Genetics, Breast Cancer, 2.1 Biological and endogenous factors, Aetiology, Allelic Imbalance, Antineoplastic Combined Chemotherapy Protocols, Cell Cycle Proteins, Cell Line, Tumor, Cell Nucleus, Cell Survival, Chromosomal Instability, Cluster Analysis, DNA Copy Number Variations, Drug Resistance, Neoplasm, Gene Expression, Gene Expression Profiling, Gene Silencing, Genomics, Homologous Recombination, Humans, Platinum, Polymorphism, Single Nucleotide, RNA, Small Interfering, Triple Negative Breast Neoplasms, Oncology and Carcinogenesis
Abstract

UnlabelledTriple-negative breast cancers (TNBC) are characterized by a wide spectrum of genomic alterations, some of which might be caused by defects in DNA repair processes such as homologous recombination (HR). Despite this understanding, associating particular patterns of genomic instability with response to therapy has been challenging. Here, we show that allelic-imbalanced copy-number aberrations (AiCNA) are more prevalent in TNBCs that respond to platinum-based chemotherapy, thus providing a candidate predictive biomarker for this disease. Furthermore, we show that a high level of AiCNA is linked with elevated expression of a meiosis-associated gene, HORMAD1. Elevated HORMAD1 expression suppresses RAD51-dependent HR and drives the use of alternative forms of DNA repair, the generation of AiCNAs, as well as sensitizing cancer cells to HR-targeting therapies. Our data therefore provide a mechanistic association between HORMAD1 expression, a specific pattern of genomic instability, and an association with response to platinum-based chemotherapy in TNBC.SignificancePrevious studies have shown correlation between mutational "scars" and sensitivity to platinums extending beyond associations with BRCA1/2 mutation, but do not elucidate the mechanism. Here, a novel allele-specific copy-number characterization of genome instability identifies and functionally validates the inappropriate expression of the meiotic gene HORMAD1 as a driver of HR deficiency in TNBC, acting to induce allelic imbalance and moderate platinum and PARP inhibitor sensitivity with implications for the use of such "scars" and expression of meiotic genes as predictive biomarkers.

Published
2015

11. Genetic predisposition to in situ and invasive lobular carcinoma of the breast.

Author

Sawyer, Elinor, Roylance, Rebecca, Petridis, Christos, Brook, Mark, Nowinski, Salpie, Papouli, Efterpi, Fletcher, Olivia, Pinder, Sarah, Hanby, Andrew, Kohut, Kelly, Gorman, Patricia, Caneppele, Michele, Peto, Julian, Dos Santos Silva, Isabel, Johnson, Nichola, Swann, Ruth, Dwek, Miriam, Perkins, Katherine-Anne, Gillett, Cheryl, Houlston, Richard, Ross, Gillian, De Ieso, Paolo, Southey, Melissa, Hopper, John, Provenzano, Elena, Apicella, Carmel, Wesseling, Jelle, Cornelissen, Sten, Keeman, Renske, Fasching, Peter, Jud, Sebastian, Ekici, Arif, Beckmann, Matthias, Kerin, Michael, Marme, Federick, Schneeweiss, Andreas, Sohn, Christof, Burwinkel, Barbara, Guénel, Pascal, Truong, Therese, Laurent-Puig, Pierre, Kerbrat, Pierre, Bojesen, Stig, Nordestgaard, Børge, Nielsen, Sune, Flyger, Henrik, Milne, Roger, Perez, Jose, Menéndez, Primitiva, Benitez, Javier, Brenner, Hermann, Dieffenbach, Aida, Arndt, Volker, Stegmaier, Christa, Meindl, Alfons, Lichtner, Peter, Schmutzler, Rita, Lochmann, Magdalena, Brauch, Hiltrud, Fischer, Hans-Peter, Ko, Yon-Dschun, Nevanlinna, Heli, Muranen, Taru, Aittomäki, Kristiina, Blomqvist, Carl, Bogdanova, Natalia, Dörk, Thilo, Lindblom, Annika, Margolin, Sara, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli-Matti, Hartikainen, Jaana, Chenevix-Trench, Georgia, Lambrechts, Diether, Weltens, Caroline, Van Limbergen, Erik, Hatse, Sigrid, Chang-Claude, Jenny, Rudolph, Anja, Seibold, Petra, Flesch-Janys, Dieter, Radice, Paolo, Peterlongo, Paolo, Bonanni, Bernardo, Volorio, Sara, Giles, Graham, Severi, Gianluca, Baglietto, Laura, McLean, Catriona, Haiman, Christopher, Henderson, Brian, Schumacher, Fredrick, Le Marchand, Loic, Simard, Jacques, Goldberg, Mark, Labrèche, France, Dumont, Martine, Kristensen, Vessela, and Winqvist, Robert

Subjects
Breast Neoplasms, Carcinoma in Situ, Carcinoma, Lobular, Case-Control Studies, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Middle Aged, Polymorphism, Single Nucleotide
Abstract

Invasive lobular breast cancer (ILC) accounts for 10-15% of all invasive breast carcinomas. It is generally ER positive (ER+) and often associated with lobular carcinoma in situ (LCIS). Genome-wide association studies have identified more than 70 common polymorphisms that predispose to breast cancer, but these studies included predominantly ductal (IDC) carcinomas. To identify novel common polymorphisms that predispose to ILC and LCIS, we pooled data from 6,023 cases (5,622 ILC, 401 pure LCIS) and 34,271 controls from 36 studies genotyped using the iCOGS chip. Six novel SNPs most strongly associated with ILC/LCIS in the pooled analysis were genotyped in a further 516 lobular cases (482 ILC, 36 LCIS) and 1,467 controls. These analyses identified a lobular-specific SNP at 7q34 (rs11977670, OR (95%CI) for ILC = 1.13 (1.09-1.18), P = 6.0 × 10(-10); P-het for ILC vs IDC ER+ tumors = 1.8 × 10(-4)). Of the 75 known breast cancer polymorphisms that were genotyped, 56 were associated with ILC and 15 with LCIS at P

Published
2014

12. An optimized five-gene multi-platform predictor of hormone receptor negative and triple negative breast cancer metastatic risk

Author

Yau, Christina, Sninsky, John, Kwok, Shirley, Wang, Alice, Degnim, Amy, Ingle, James N, Gillett, Cheryl, Tutt, Andrew, Waldman, Fred, Moore, Dan, Esserman, Laura, and Benz, Christopher C

Abstract

Abstract Introduction Outcome predictors in use today are prognostic only for hormone receptor-positive (HRpos) breast cancer. Although microarray-derived multigene predictors of hormone receptor-negative (HRneg) and/or triple negative (Tneg) breast cancer recurrence risk are emerging, to date none have been transferred to clinically suitable assay platforms (for example, RT-PCR) or validated against formalin-fixed paraffin-embedded (FFPE) HRneg/Tneg samples. Methods Multiplexed RT-PCR was used to assay two microarray-derived HRneg/Tneg prognostic signatures IR-7 and Buck-4) in a pooled FFPE collection of 139 chemotherapy-naïve HRneg breast cancers. The prognostic value of the RT-PCR measured gene signatures were evaluated as continuous and dichotomous variables, and in conditional risk models incorporating clinical parameters. An optimized five-gene index was derived by evaluating gene combinations from both signatures. Results RT-PCR measured IR-7 and Buck-4 signatures proved prognostic as continuous variables; and conditional risk modeling chose nodal status, the IR-7 signature, and tumor grade as significant predictors of distant recurrence (DR). From the Buck-4 and IR-7 signatures, an optimized five-gene (TNFRSF17, CLIC5, HLA-F, CXCL13, XCL2) predictor was generated, referred to as the Integrated Cytokine Score (ICS) based on its functional pathway linkage through interferon-γ and IL-10. Across all FFPE cases, the ICS was prognostic as either a continuous or dichotomous variable, and conditional risk modeling selected nodal status and ICS as DR predictors. Further dichotomization of node-negative/ICS-low FFPE cases identified a subset of low-grade HRneg tumors with

Published
2013

13. Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups

Author

Rueda, Oscar M., Sammut, Stephen-John, Seoane, Jose A., Chin, Suet-Feung, Caswell-Jin, Jennifer L., Callari, Maurizio, Batra, Rajbir, Pereira, Bernard, Bruna, Alejandra, Ali, H. Raza, Provenzano, Elena, Liu, Bin, Parisien, Michelle, Gillett, Cheryl, McKinney, Steven, Green, Andrew R., Murphy, Leigh, Purushotham, Arnie, Ellis, Ian O., Pharoah, Paul D., Rueda, Cristina, Aparicio, Samuel, Caldas, Carlos, and Curtis, Christina

Published
2019
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14. Risk estimation of distant metastasis in node-negative, estrogen receptor-positive breast cancer patients using an RT-PCR based prognostic expression signature

Author

Tutt, Andrew, Wang, Alice, Rowland, Charles, Gillett, Cheryl, Lau, Kit, Chew, Karen, Dai, Hongyue, Kwok, Shirley, Ryder, Kenneth, Shu, Henry, Springall, Robert, Cane, Paul, McCallie, Blair, Kam-Morgan, Lauren, Anderson, Steve, Buerger, Horst, Gray, Joe, Bennington, James, Esserman, Laura, Hastie, Trevor, Broder, Samuel, Sninsky, John, Brandt, Burkhard, and Waldman, Fred

Subjects
Prevention, Breast Cancer, Genetics, Cancer, Clinical Research, Aetiology, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, 2.1 Biological and endogenous factors, 4.2 Evaluation of markers and technologies, Adult, Aged, Aged, 80 and over, Breast Neoplasms, Chi-Square Distribution, Disease-Free Survival, Female, Gene Expression Profiling, Humans, Kaplan-Meier Estimate, Lymph Nodes, Middle Aged, Neoplasm Metastasis, Proportional Hazards Models, ROC Curve, Receptors, Estrogen, Reverse Transcriptase Polymerase Chain Reaction, Sensitivity and Specificity, Statistics, Nonparametric, Survival Analysis, Oncology and Carcinogenesis, Public Health and Health Services, Oncology & Carcinogenesis
Abstract

BackgroundGiven the large number of genes purported to be prognostic for breast cancer, it would be optimal if the genes identified are not confounded by the continuously changing systemic therapies. The aim of this study was to discover and validate a breast cancer prognostic expression signature for distant metastasis in untreated, early stage, lymph node-negative (N-) estrogen receptor-positive (ER+) patients with extensive follow-up times.Methods197 genes previously associated with metastasis and ER status were profiled from 142 untreated breast cancer subjects. A "metastasis score" (MS) representing fourteen differentially expressed genes was developed and evaluated for its association with distant-metastasis-free survival (DMFS). Categorical risk classification was established from the continuous MS and further evaluated on an independent set of 279 untreated subjects. A third set of 45 subjects was tested to determine the prognostic performance of the MS in tamoxifen-treated women.ResultsA 14-gene signature was found to be significantly associated (p < 0.05) with distant metastasis in a training set and subsequently in an independent validation set. In the validation set, the hazard ratios (HR) of the high risk compared to low risk groups were 4.02 (95% CI 1.91-8.44) for the endpoint of DMFS and 1.97 (95% CI 1.28 to 3.04) for overall survival after adjustment for age, tumor size and grade. The low and high MS risk groups had 10-year estimates (95% CI) of 96% (90-99%) and 72% (64-78%) respectively, for DMFS and 91% (84-95%) and 68% (61-75%), respectively for overall survival. Performance characteristics of the signature in the two sets were similar. Ki-67 labeling index (LI) was predictive for recurrent disease in the training set, but lost significance after adjustment for the expression signature. In a study of tamoxifen-treated patients, the HR for DMFS in high compared to low risk groups was 3.61 (95% CI 0.86-15.14).ConclusionThe 14-gene signature is significantly associated with risk of distant metastasis. The signature has a predominance of proliferation genes which have prognostic significance above that of Ki-67 LI and may aid in prioritizing future mechanistic studies and therapeutic interventions.

Published
2008

16. Cohort profile: King’s Health Partners bladder cancer biobank

Author

Kotecha, Pinky, Moss, Charlotte L., Enting, Deborah, Gillett, Cheryl, Joseph, Magdalene, Josephs, Debra, Rudman, Sarah, Hughes, Simon, Cahill, Fidelma, Wylie, Harriet, Haire, Anna, Rosekilly, James, Khan, Muhammad Shamin, Nair, Rajesh, Thurairaja, Ramesh, Malde, Sachin, and Van Hemelrijck, Mieke

Published
2020
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17. Carboplatin in BRCA1/2-mutated and triple-negative breast cancer BRCAness subgroups: the TNT Trial

Author

Tutt, Andrew, Tovey, Holly, Cheang, Maggie Chon U., Kernaghan, Sarah, Kilburn, Lucy, Gazinska, Patrycja, Owen, Julie, Abraham, Jacinta, Barrett, Sophie, Barrett-Lee, Peter, Brown, Robert, Chan, Stephen, Dowsett, Mitchell, Flanagan, James M, Fox, Lisa, Grigoriadis, Anita, Gutin, Alexander, Harper-Wynne, Catherine, Hatton, Matthew Q., Hoadley, Katherine A., Parikh, Jyoti, Parker, Peter, Perou, Charles M., Roylance, Rebecca, Shah, Vandna, Shaw, Adam, Smith, Ian E., Timms, Kirsten M., Wardley, Andrew M., Wilson, Gregory, Gillett, Cheryl, Lanchbury, Jerry S., Ashworth, Alan, Rahman, Nazneen, Harries, Mark, Ellis, Paul, Pinder, Sarah E., and Bliss, Judith M.

Published
2018
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19. Multiscale deep learning framework captures systemic immune features in lymph nodes predictive of triple negative breast cancer outcome in large‐scale studies

Author

Verghese, Gregory, primary, Li, Mengyuan, additional, Liu, Fangfang, additional, Lohan, Amit, additional, Kurian, Nikhil Cherian, additional, Meena, Swati, additional, Gazinska, Patrycja, additional, Shah, Aekta, additional, Oozeer, Aasiyah, additional, Chan, Terry, additional, Opdam, Mark, additional, Linn, Sabine, additional, Gillett, Cheryl, additional, Alberts, Elena, additional, Hardiman, Thomas, additional, Jones, Samantha, additional, Thavaraj, Selvam, additional, Jones, J Louise, additional, Salgado, Roberto, additional, Pinder, Sarah E, additional, Rane, Swapnil, additional, Sethi, Amit, additional, and Grigoriadis, Anita, additional

Published
2023
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20. Data from Genomic Complexity Profiling Reveals That HORMAD1 Overexpression Contributes to Homologous Recombination Deficiency in Triple-Negative Breast Cancers

Author

Watkins, Johnathan, primary, Weekes, Daniel, primary, Shah, Vandna, primary, Gazinska, Patrycja, primary, Joshi, Shalaka, primary, Sidhu, Bhavna, primary, Gillett, Cheryl, primary, Pinder, Sarah, primary, Vanoli, Fabio, primary, Jasin, Maria, primary, Mayrhofer, Markus, primary, Isaksson, Anders, primary, Cheang, Maggie C.U., primary, Mirza, Hasan, primary, Frankum, Jessica, primary, Lord, Christopher J., primary, Ashworth, Alan, primary, Vinayak, Shaveta, primary, Ford, James M., primary, Telli, Melinda L., primary, Grigoriadis, Anita, primary, and Tutt, Andrew N.J., primary

Published
2023
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21. Supplementary Tables S1 - S4 from Genomic Complexity Profiling Reveals That HORMAD1 Overexpression Contributes to Homologous Recombination Deficiency in Triple-Negative Breast Cancers

Author

Watkins, Johnathan, primary, Weekes, Daniel, primary, Shah, Vandna, primary, Gazinska, Patrycja, primary, Joshi, Shalaka, primary, Sidhu, Bhavna, primary, Gillett, Cheryl, primary, Pinder, Sarah, primary, Vanoli, Fabio, primary, Jasin, Maria, primary, Mayrhofer, Markus, primary, Isaksson, Anders, primary, Cheang, Maggie C.U., primary, Mirza, Hasan, primary, Frankum, Jessica, primary, Lord, Christopher J., primary, Ashworth, Alan, primary, Vinayak, Shaveta, primary, Ford, James M., primary, Telli, Melinda L., primary, Grigoriadis, Anita, primary, and Tutt, Andrew N.J., primary

Published
2023
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22. Supplementary File from Genomic Complexity Profiling Reveals That HORMAD1 Overexpression Contributes to Homologous Recombination Deficiency in Triple-Negative Breast Cancers

Author

Watkins, Johnathan, primary, Weekes, Daniel, primary, Shah, Vandna, primary, Gazinska, Patrycja, primary, Joshi, Shalaka, primary, Sidhu, Bhavna, primary, Gillett, Cheryl, primary, Pinder, Sarah, primary, Vanoli, Fabio, primary, Jasin, Maria, primary, Mayrhofer, Markus, primary, Isaksson, Anders, primary, Cheang, Maggie C.U., primary, Mirza, Hasan, primary, Frankum, Jessica, primary, Lord, Christopher J., primary, Ashworth, Alan, primary, Vinayak, Shaveta, primary, Ford, James M., primary, Telli, Melinda L., primary, Grigoriadis, Anita, primary, and Tutt, Andrew N.J., primary

Published
2023
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23. Supplementary Figures S1 - S16 from Genomic Complexity Profiling Reveals That HORMAD1 Overexpression Contributes to Homologous Recombination Deficiency in Triple-Negative Breast Cancers

Author

Watkins, Johnathan, primary, Weekes, Daniel, primary, Shah, Vandna, primary, Gazinska, Patrycja, primary, Joshi, Shalaka, primary, Sidhu, Bhavna, primary, Gillett, Cheryl, primary, Pinder, Sarah, primary, Vanoli, Fabio, primary, Jasin, Maria, primary, Mayrhofer, Markus, primary, Isaksson, Anders, primary, Cheang, Maggie C.U., primary, Mirza, Hasan, primary, Frankum, Jessica, primary, Lord, Christopher J., primary, Ashworth, Alan, primary, Vinayak, Shaveta, primary, Ford, James M., primary, Telli, Melinda L., primary, Grigoriadis, Anita, primary, and Tutt, Andrew N.J., primary

Published
2023
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24. Supplementary Methods, Figure Legends, Table Legends from Genomic Complexity Profiling Reveals That HORMAD1 Overexpression Contributes to Homologous Recombination Deficiency in Triple-Negative Breast Cancers

Author

Watkins, Johnathan, primary, Weekes, Daniel, primary, Shah, Vandna, primary, Gazinska, Patrycja, primary, Joshi, Shalaka, primary, Sidhu, Bhavna, primary, Gillett, Cheryl, primary, Pinder, Sarah, primary, Vanoli, Fabio, primary, Jasin, Maria, primary, Mayrhofer, Markus, primary, Isaksson, Anders, primary, Cheang, Maggie C.U., primary, Mirza, Hasan, primary, Frankum, Jessica, primary, Lord, Christopher J., primary, Ashworth, Alan, primary, Vinayak, Shaveta, primary, Ford, James M., primary, Telli, Melinda L., primary, Grigoriadis, Anita, primary, and Tutt, Andrew N.J., primary

Published
2023
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25. Supplementary Data from Dynamic Changes in the NK-, Neutrophil-, and B-cell Immunophenotypes Relevant in High Metastatic Risk Post Neoadjuvant Chemotherapy–Resistant Early Breast Cancers

Author

Gazinska, Patrycja, primary, Milton, Charlotte, primary, Iacovacci, Jacopo, primary, Ward, Joseph, primary, Buus, Richard, primary, Alaguthurai, Thanussuyah, primary, Graham, Rosalind, primary, Akarca, Ayse, primary, Lips, Esther, primary, Naidoo, Kalnisha, primary, Wesseling, Jelle, primary, Marafioti, Teresa, primary, Cheang, Maggie, primary, Gillett, Cheryl, primary, Wu, Yin, primary, Khan, Aadil, primary, Melcher, Alan, primary, Salgado, Roberto, primary, Dowsett, Mitch, primary, Tutt, Andrew, primary, Roxanis, Ioannis, primary, Haider, Syed, primary, and Irshad, Sheeba, primary

Published
2023
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26. Supplementary Figure from Dynamic Changes in the NK-, Neutrophil-, and B-cell Immunophenotypes Relevant in High Metastatic Risk Post Neoadjuvant Chemotherapy–Resistant Early Breast Cancers

Author

Gazinska, Patrycja, primary, Milton, Charlotte, primary, Iacovacci, Jacopo, primary, Ward, Joseph, primary, Buus, Richard, primary, Alaguthurai, Thanussuyah, primary, Graham, Rosalind, primary, Akarca, Ayse, primary, Lips, Esther, primary, Naidoo, Kalnisha, primary, Wesseling, Jelle, primary, Marafioti, Teresa, primary, Cheang, Maggie, primary, Gillett, Cheryl, primary, Wu, Yin, primary, Khan, Aadil, primary, Melcher, Alan, primary, Salgado, Roberto, primary, Dowsett, Mitch, primary, Tutt, Andrew, primary, Roxanis, Ioannis, primary, Haider, Syed, primary, and Irshad, Sheeba, primary

Published
2023
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28. Data from RORγt+ Innate Lymphoid Cells Promote Lymph Node Metastasis of Breast Cancers

Author

Irshad, Sheeba, primary, Flores-Borja, Fabian, primary, Lawler, Katherine, primary, Monypenny, James, primary, Evans, Rachel, primary, Male, Victoria, primary, Gordon, Peter, primary, Cheung, Anthony, primary, Gazinska, Patrycja, primary, Noor, Farzana, primary, Wong, Felix, primary, Grigoriadis, Anita, primary, Fruhwirth, Gilbert O., primary, Barber, Paul R., primary, Woodman, Natalie, primary, Patel, Dominic, primary, Rodriguez-Justo, Manuel, primary, Owen, Julie, primary, Martin, Stewart G., primary, Pinder, Sarah E., primary, Gillett, Cheryl E., primary, Poland, Simon P., primary, Ameer-Beg, Simon, primary, McCaughan, Frank, primary, Carlin, Leo M., primary, Hasan, Uzma, primary, Withers, David R., primary, Lane, Peter, primary, Vojnovic, Borivoj, primary, Quezada, Sergio A., primary, Ellis, Paul, primary, Tutt, Andrew N.J., primary, and Ng, Tony, primary

Published
2023
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29. Supplementary figures from Anti-Folate Receptor Alpha–Directed Antibody Therapies Restrict the Growth of Triple-negative Breast Cancer

Author

Cheung, Anthony, primary, Opzoomer, James, primary, Ilieva, Kristina M., primary, Gazinska, Patrycja, primary, Hoffmann, Ricarda M., primary, Mirza, Hasan, primary, Marlow, Rebecca, primary, Francesch-Domenech, Erika, primary, Fittall, Matthew, primary, Dominguez Rodriguez, Diana, primary, Clifford, Angela, primary, Badder, Luned, primary, Patel, Nirmesh, primary, Mele, Silvia, primary, Pellizzari, Giulia, primary, Bax, Heather J., primary, Crescioli, Silvia, primary, Petranyi, Gyula, primary, Larcombe-Young, Daniel, primary, Josephs, Debra H., primary, Canevari, Silvana, primary, Figini, Mariangela, primary, Pinder, Sarah, primary, Nestle, Frank O., primary, Gillett, Cheryl, primary, Spicer, James F., primary, Grigoriadis, Anita, primary, Tutt, Andrew N.J., primary, and Karagiannis, Sophia N., primary

Published
2023
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30. Video S2, Related to Figure 2 from RORγt+ Innate Lymphoid Cells Promote Lymph Node Metastasis of Breast Cancers

Author

Irshad, Sheeba, primary, Flores-Borja, Fabian, primary, Lawler, Katherine, primary, Monypenny, James, primary, Evans, Rachel, primary, Male, Victoria, primary, Gordon, Peter, primary, Cheung, Anthony, primary, Gazinska, Patrycja, primary, Noor, Farzana, primary, Wong, Felix, primary, Grigoriadis, Anita, primary, Fruhwirth, Gilbert O., primary, Barber, Paul R., primary, Woodman, Natalie, primary, Patel, Dominic, primary, Rodriguez-Justo, Manuel, primary, Owen, Julie, primary, Martin, Stewart G., primary, Pinder, Sarah E., primary, Gillett, Cheryl E., primary, Poland, Simon P., primary, Ameer-Beg, Simon, primary, McCaughan, Frank, primary, Carlin, Leo M., primary, Hasan, Uzma, primary, Withers, David R., primary, Lane, Peter, primary, Vojnovic, Borivoj, primary, Quezada, Sergio A., primary, Ellis, Paul, primary, Tutt, Andrew N.J., primary, and Ng, Tony, primary

Published
2023
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31. Supplementary Figures 1-10, Supplementary Materials and Methods, Supplementary References from Repurposing Tin Mesoporphyrin as an Immune Checkpoint Inhibitor Shows Therapeutic Efficacy in Preclinical Models of Cancer

Author

Muliaditan, Tamara, primary, Opzoomer, James W., primary, Caron, Jonathan, primary, Okesola, Mary, primary, Kosti, Paris, primary, Lall, Sharanpreet, primary, Van Hemelrijck, Mieke, primary, Dazzi, Francesco, primary, Tutt, Andrew, primary, Grigoriadis, Anita, primary, Gillett, Cheryl E., primary, Madden, Stephen F., primary, Burchell, Joy M., primary, Kordasti, Shahram, primary, Diebold, Sandra S., primary, Spicer, James F., primary, and Arnold, James N., primary

Published
2023
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32. Supplementary Table from Repurposing Tin Mesoporphyrin as an Immune Checkpoint Inhibitor Shows Therapeutic Efficacy in Preclinical Models of Cancer

Author

Muliaditan, Tamara, primary, Opzoomer, James W., primary, Caron, Jonathan, primary, Okesola, Mary, primary, Kosti, Paris, primary, Lall, Sharanpreet, primary, Van Hemelrijck, Mieke, primary, Dazzi, Francesco, primary, Tutt, Andrew, primary, Grigoriadis, Anita, primary, Gillett, Cheryl E., primary, Madden, Stephen F., primary, Burchell, Joy M., primary, Kordasti, Shahram, primary, Diebold, Sandra S., primary, Spicer, James F., primary, and Arnold, James N., primary

Published
2023
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33. Supplementary Figures & Tables from RORγt+ Innate Lymphoid Cells Promote Lymph Node Metastasis of Breast Cancers

Author

Irshad, Sheeba, primary, Flores-Borja, Fabian, primary, Lawler, Katherine, primary, Monypenny, James, primary, Evans, Rachel, primary, Male, Victoria, primary, Gordon, Peter, primary, Cheung, Anthony, primary, Gazinska, Patrycja, primary, Noor, Farzana, primary, Wong, Felix, primary, Grigoriadis, Anita, primary, Fruhwirth, Gilbert O., primary, Barber, Paul R., primary, Woodman, Natalie, primary, Patel, Dominic, primary, Rodriguez-Justo, Manuel, primary, Owen, Julie, primary, Martin, Stewart G., primary, Pinder, Sarah E., primary, Gillett, Cheryl E., primary, Poland, Simon P., primary, Ameer-Beg, Simon, primary, McCaughan, Frank, primary, Carlin, Leo M., primary, Hasan, Uzma, primary, Withers, David R., primary, Lane, Peter, primary, Vojnovic, Borivoj, primary, Quezada, Sergio A., primary, Ellis, Paul, primary, Tutt, Andrew N.J., primary, and Ng, Tony, primary

Published
2023
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34. Supplementary Movie Legends 1-2 from Selectin Ligand Sialyl-Lewis x Antigen Drives Metastasis of Hormone-Dependent Breast Cancers

Author

Julien, Sylvain, primary, Ivetic, Aleksandar, primary, Grigoriadis, Anita, primary, QiZe, Ding, primary, Burford, Brian, primary, Sproviero, Daisy, primary, Picco, Gianfranco, primary, Gillett, Cheryl, primary, Papp, Suzanne L., primary, Schaffer, Lana, primary, Tutt, Andrew, primary, Taylor-Papadimitriou, Joyce, primary, Pinder, Sarah E., primary, and Burchell, Joy M., primary

Published
2023
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35. Supplementary Figures 1-7 from FGFR1 Amplification Drives Endocrine Therapy Resistance and Is a Therapeutic Target in Breast Cancer

Author

Turner, Nicholas, primary, Pearson, Alex, primary, Sharpe, Rachel, primary, Lambros, Maryou, primary, Geyer, Felipe, primary, Lopez-Garcia, Maria A., primary, Natrajan, Rachael, primary, Marchio, Caterina, primary, Iorns, Elizabeth, primary, Mackay, Alan, primary, Gillett, Cheryl, primary, Grigoriadis, Anita, primary, Tutt, Andrew, primary, Reis-Filho, Jorge S., primary, and Ashworth, Alan, primary

Published
2023
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36. Data from FGFR1 Amplification Drives Endocrine Therapy Resistance and Is a Therapeutic Target in Breast Cancer

Author

Turner, Nicholas, primary, Pearson, Alex, primary, Sharpe, Rachel, primary, Lambros, Maryou, primary, Geyer, Felipe, primary, Lopez-Garcia, Maria A., primary, Natrajan, Rachael, primary, Marchio, Caterina, primary, Iorns, Elizabeth, primary, Mackay, Alan, primary, Gillett, Cheryl, primary, Grigoriadis, Anita, primary, Tutt, Andrew, primary, Reis-Filho, Jorge S., primary, and Ashworth, Alan, primary

Published
2023
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37. Supplementary Figure 1 from Selectin Ligand Sialyl-Lewis x Antigen Drives Metastasis of Hormone-Dependent Breast Cancers

Author

Julien, Sylvain, primary, Ivetic, Aleksandar, primary, Grigoriadis, Anita, primary, QiZe, Ding, primary, Burford, Brian, primary, Sproviero, Daisy, primary, Picco, Gianfranco, primary, Gillett, Cheryl, primary, Papp, Suzanne L., primary, Schaffer, Lana, primary, Tutt, Andrew, primary, Taylor-Papadimitriou, Joyce, primary, Pinder, Sarah E., primary, and Burchell, Joy M., primary

Published
2023
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38. Supplementary Methods and Results from Selectin Ligand Sialyl-Lewis x Antigen Drives Metastasis of Hormone-Dependent Breast Cancers

Author

Julien, Sylvain, primary, Ivetic, Aleksandar, primary, Grigoriadis, Anita, primary, QiZe, Ding, primary, Burford, Brian, primary, Sproviero, Daisy, primary, Picco, Gianfranco, primary, Gillett, Cheryl, primary, Papp, Suzanne L., primary, Schaffer, Lana, primary, Tutt, Andrew, primary, Taylor-Papadimitriou, Joyce, primary, Pinder, Sarah E., primary, and Burchell, Joy M., primary

Published
2023
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39. Supplementary Tables 1-3 from Selectin Ligand Sialyl-Lewis x Antigen Drives Metastasis of Hormone-Dependent Breast Cancers

Author

Julien, Sylvain, primary, Ivetic, Aleksandar, primary, Grigoriadis, Anita, primary, QiZe, Ding, primary, Burford, Brian, primary, Sproviero, Daisy, primary, Picco, Gianfranco, primary, Gillett, Cheryl, primary, Papp, Suzanne L., primary, Schaffer, Lana, primary, Tutt, Andrew, primary, Taylor-Papadimitriou, Joyce, primary, Pinder, Sarah E., primary, and Burchell, Joy M., primary

Published
2023
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40. Supplementary Figure 5 from Selectin Ligand Sialyl-Lewis x Antigen Drives Metastasis of Hormone-Dependent Breast Cancers

Author

Julien, Sylvain, primary, Ivetic, Aleksandar, primary, Grigoriadis, Anita, primary, QiZe, Ding, primary, Burford, Brian, primary, Sproviero, Daisy, primary, Picco, Gianfranco, primary, Gillett, Cheryl, primary, Papp, Suzanne L., primary, Schaffer, Lana, primary, Tutt, Andrew, primary, Taylor-Papadimitriou, Joyce, primary, Pinder, Sarah E., primary, and Burchell, Joy M., primary

Published
2023
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41. Supplementary Figure 3 from Selectin Ligand Sialyl-Lewis x Antigen Drives Metastasis of Hormone-Dependent Breast Cancers

Author

Julien, Sylvain, primary, Ivetic, Aleksandar, primary, Grigoriadis, Anita, primary, QiZe, Ding, primary, Burford, Brian, primary, Sproviero, Daisy, primary, Picco, Gianfranco, primary, Gillett, Cheryl, primary, Papp, Suzanne L., primary, Schaffer, Lana, primary, Tutt, Andrew, primary, Taylor-Papadimitriou, Joyce, primary, Pinder, Sarah E., primary, and Burchell, Joy M., primary

Published
2023
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42. Supplementary Methods, Figure Legends 1-7 from FGFR1 Amplification Drives Endocrine Therapy Resistance and Is a Therapeutic Target in Breast Cancer

Author

Turner, Nicholas, primary, Pearson, Alex, primary, Sharpe, Rachel, primary, Lambros, Maryou, primary, Geyer, Felipe, primary, Lopez-Garcia, Maria A., primary, Natrajan, Rachael, primary, Marchio, Caterina, primary, Iorns, Elizabeth, primary, Mackay, Alan, primary, Gillett, Cheryl, primary, Grigoriadis, Anita, primary, Tutt, Andrew, primary, Reis-Filho, Jorge S., primary, and Ashworth, Alan, primary

Published
2023
Full Text
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43. Data from Selectin Ligand Sialyl-Lewis x Antigen Drives Metastasis of Hormone-Dependent Breast Cancers

Author

Julien, Sylvain, primary, Ivetic, Aleksandar, primary, Grigoriadis, Anita, primary, QiZe, Ding, primary, Burford, Brian, primary, Sproviero, Daisy, primary, Picco, Gianfranco, primary, Gillett, Cheryl, primary, Papp, Suzanne L., primary, Schaffer, Lana, primary, Tutt, Andrew, primary, Taylor-Papadimitriou, Joyce, primary, Pinder, Sarah E., primary, and Burchell, Joy M., primary

Published
2023
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44. Supplementary Figure 2 from Selectin Ligand Sialyl-Lewis x Antigen Drives Metastasis of Hormone-Dependent Breast Cancers

Author

Julien, Sylvain, primary, Ivetic, Aleksandar, primary, Grigoriadis, Anita, primary, QiZe, Ding, primary, Burford, Brian, primary, Sproviero, Daisy, primary, Picco, Gianfranco, primary, Gillett, Cheryl, primary, Papp, Suzanne L., primary, Schaffer, Lana, primary, Tutt, Andrew, primary, Taylor-Papadimitriou, Joyce, primary, Pinder, Sarah E., primary, and Burchell, Joy M., primary

Published
2023
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45. Supplementary materials and methods and Supplementary figure legends revised from Tumor-Infiltrating B Lymphocyte Profiling Identifies IgG-Biased, Clonally Expanded Prognostic Phenotypes in Triple-Negative Breast Cancer

Author

Harris, Robert J., primary, Cheung, Anthony, primary, Ng, Joseph C.F., primary, Laddach, Roman, primary, Chenoweth, Alicia M., primary, Crescioli, Silvia, primary, Fittall, Matthew, primary, Dominguez-Rodriguez, Diana, primary, Roberts, James, primary, Levi, Dina, primary, Liu, Fangfang, primary, Alberts, Elena, primary, Quist, Jelmar, primary, Santaolalla, Aida, primary, Pinder, Sarah E., primary, Gillett, Cheryl, primary, Hammar, Niklas, primary, Irshad, Sheeba, primary, Van Hemelrijck, Mieke, primary, Dunn-Walters, Deborah K., primary, Fraternali, Franca, primary, Spicer, James F., primary, Lacy, Katie E., primary, Tsoka, Sophia, primary, Grigoriadis, Anita, primary, Tutt, Andrew N.J., primary, and Karagiannis, Sophia N., primary

Published
2023
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46. Supplementary tables and figures from Tumor-Infiltrating B Lymphocyte Profiling Identifies IgG-Biased, Clonally Expanded Prognostic Phenotypes in Triple-Negative Breast Cancer

Author

Harris, Robert J., primary, Cheung, Anthony, primary, Ng, Joseph C.F., primary, Laddach, Roman, primary, Chenoweth, Alicia M., primary, Crescioli, Silvia, primary, Fittall, Matthew, primary, Dominguez-Rodriguez, Diana, primary, Roberts, James, primary, Levi, Dina, primary, Liu, Fangfang, primary, Alberts, Elena, primary, Quist, Jelmar, primary, Santaolalla, Aida, primary, Pinder, Sarah E., primary, Gillett, Cheryl, primary, Hammar, Niklas, primary, Irshad, Sheeba, primary, Van Hemelrijck, Mieke, primary, Dunn-Walters, Deborah K., primary, Fraternali, Franca, primary, Spicer, James F., primary, Lacy, Katie E., primary, Tsoka, Sophia, primary, Grigoriadis, Anita, primary, Tutt, Andrew N.J., primary, and Karagiannis, Sophia N., primary

Published
2023
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47. Abstract P5-01-01: Multiscale Deep Learning framework to capture systemic immune features in lymph nodes predictive of triple negative breast cancer outcome

Author

Verghese, Gregory, primary, Li, Mengyuan, additional, Liu, Fangfang, additional, Lohan, Amit, additional, Cherian, Nikhil, additional, Gazinska, Patrycja, additional, Shah, Aekta, additional, Oozeer, Aasiyah, additional, Gillett, Cheryl, additional, Alberts, Elena, additional, Hardiman, Thomas, additional, Salgado, Roberto, additional, Jones, Samantha, additional, Jones, Louise, additional, Thavaraj, Selvam, additional, Pinder, Sarah E., additional, Rane, Swapni, additional, Sethi, Amit, additional, and Grigoriadis, Anita, additional

Published
2023
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48. LYVE-1+ macrophages form a collaborative CCR5-dependent perivascular niche that influences chemotherapy responses in murine breast cancer.

Author

Afd Pharmacology, Pharmacology, Anstee, Joanne E, Feehan, Karen T, Opzoomer, James W, Dean, Isaac, Muller, Henrike P, Bahri, Meriem, Cheung, Tik Shing, Liakath-Ali, Kifayathullah, Liu, Ziyan, Choy, Desmond, Caron, Jonathan, Sosnowska, Dominika, Beatson, Richard, Muliaditan, Tamara, An, Zhengwen, Gillett, Cheryl E, Lan, Guocheng, Zou, Xiangang, Watt, Fiona M, Ng, Tony, Burchell, Joy M, Kordasti, Shahram, Withers, David R, Lawrence, Toby, Arnold, James N, Afd Pharmacology, Pharmacology, Anstee, Joanne E, Feehan, Karen T, Opzoomer, James W, Dean, Isaac, Muller, Henrike P, Bahri, Meriem, Cheung, Tik Shing, Liakath-Ali, Kifayathullah, Liu, Ziyan, Choy, Desmond, Caron, Jonathan, Sosnowska, Dominika, Beatson, Richard, Muliaditan, Tamara, An, Zhengwen, Gillett, Cheryl E, Lan, Guocheng, Zou, Xiangang, Watt, Fiona M, Ng, Tony, Burchell, Joy M, Kordasti, Shahram, Withers, David R, Lawrence, Toby, and Arnold, James N

Published
2023

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