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7. Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group

Author

Schmaal, L, Veltman, D J, van Erp, T GM, Sämann, P G, Frodl, T, Jahanshad, N, Loehrer, E, Tiemeier, H, Hofman, A, Niessen, W J, Vernooij, M W, Ikram, M A, Wittfeld, K, Grabe, H J, Block, A, Hegenscheid, K, Völzke, H, Hoehn, D, Czisch, M, Lagopoulos, J, Hatton, S N, Hickie, I B, Goya-Maldonado, R, Krämer, B, Gruber, O, Couvy-Duchesne, B, Rentería, M E, Strike, L T, Mills, N T, de Zubicaray, G I, McMahon, K L, Medland, S E, Martin, N G, Gillespie, N A, Wright, M J, Hall, G B, MacQueen, G M, Frey, E M, Carballedo, A, van Velzen, L S, van Tol, M J, van der Wee, N J, Veer, I M, Walter, H, Schnell, K, Schramm, E, Normann, C, Schoepf, D, Konrad, C, Zurowski, B, Nickson, T, McIntosh, A M, Papmeyer, M, Whalley, H C, Sussmann, J E, Godlewska, B R, Cowen, P J, Fischer, F H, Rose, M, Penninx, B WJH, Thompson, P M, and Hibar, D P

Published
2016
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8. Response to Dr Fried & Dr Kievit, and Dr Malhi et al.

Author

Schmaal, L, Veltman, D J, van Erp, T GM, Sämann, P G, Frodl, T, Jahanshad, N, Loehrer, E, Vernooij, M W, Niessen, W J, Ikram, M A, Wittfeld, K, Grabe, H J, Block, A, Hegenscheid, K, Hoehn, D, Czisch, M, Lagopoulos, J, Hatton, S N, Hickie, I B, Goya-Maldonado, R, Krämer, B, Gruber, O, Couvy-Duchesne, B, Rentería, M E, Strike, L T, Wright, M J, de Zubicaray, G I, McMahon, K L, Medland, S E, Gillespie, N A, Hall, G B, van Velzen, L S, van Tol, M-J, van der Wee, N J, Veer, I M, Walter, H, Schramm, E, Normann, C, Schoepf, D, Konrad, C, Zurowski, B, McIntosh, A M, Whalley, H C, Sussmann, J E, Godlewska, B R, Fischer, F H, Penninx, B WJH, Thompson, P M, and Hibar, D P

Published
2016
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15. Cereb Cortex

Author

Shin, J., Ma, S., Hofer, E., Patel, Y., VOSBERG, D. E., TILLEY, S., ROSHCHUPKIN, G. V., SOUSA, A. M. M., JIAN, X., GOTTESMAN, R., MOSLEY, T. H., FORNAGE, M., SABA, Y., PIRPAMER, L., Schmidt, R., Schmidt, H., CARRION-CASTILLO, A., Crivello, F., Mazoyer, B., BIS, J. C., Li, S., Yang, Q., LUCIANO, M., Karama, S., Lewis, L., BASTIN, M. E., HARRIS, M. A., WARDLAW, J. M., DEARY, I. E., Scholz, M., Loeffler, M., WITTE, A. V., Beyer, F., VILLRINGER, A., ARMSTRONG, N. J., MATHER, K. A., Ames, D., Jiang, J., KWOK, J. B., SCHOFIELD, P. R., THALAMUTHU, A., TROLLOR, J. N., WRIGHT, M. J., BRODATY, H., Wen, W., SACHDEV, P. S., TERZIKHAN, N., EVANS, T. E., ADAMS, Hhhh, Ikram, M. A., FRENZEL, S., AUWERA-PALITSCHKA, S. V., WITTFELD, K., BULOW, R., Grabe, H. J., Tzourio, Christophe, Mishra, Aniket, MAINGAULT, S., Debette, Stéphanie, GILLESPIE, N. A., FRANZ, C. E., KREMEN, W. S., Ding, L., JAHANSHAD, N., Sestan, N., PAUSOVA, Z., SESHADRI, S., PAUS, T., Bordeaux population health (BPH), and Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
endocrine system, VINTAGE, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Abstract

We have carried out meta-analyses of genome-wide association studies (GWAS) (n = 23 784) of the first two principal components (PCs) that group together cortical regions with shared variance in their surface area. PC1 (global) captured variations of most regions, whereas PC2 (visual) was specific to the primary and secondary visual cortices. We identified a total of 18 (PC1) and 17 (PC2) independent loci, which were replicated in another 25 746 individuals. The loci of the global PC1 included those associated previously with intracranial volume and/or general cognitive function, such as MAPT and IGF2BP1. The loci of the visual PC2 included DAAM1, a key player in the planar-cell-polarity pathway. We then tested associations with occupational aptitudes and, as predicted, found that the global PC1 was associated with General Learning Ability, and the visual PC2 was associated with the Form Perception aptitude. These results suggest that interindividual variations in global and regional development of the human cerebral cortex (and its molecular architecture) cascade—albeit in a very limited manner—to behaviors as complex as the choice of one’s occupation.

Published
2020
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16. Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Author

Davies, G., Lam, M., Harris, S. E., TRAMPUSH, J. W., LUCIANO, M., HILL, W. D., HAGENAARS, S. P., RITCHIE, S. J., MARIONI, R. E., FAWNS-RITCHIE, C., LIEWALD, D. C. M., OKELY, J. A., AHOLA-OLLI, A. V., BARNES, C. L. K., Bertram, L., BIS, J. C., BURDICK, K. E., CHRISTOFOROU, A., DEROSSE, P., Djurovic, S., ESPESETH, T., GIAKOUMAKI, S., GIDDALURU, S., GUSTAVSON, D. E., Hayward, C., Hofer, E., KARLSSON, R., KNOWLES, E., Lahti, J., Leber, M., MATHER, K. A., Melle, I., Morris, D., OLDMEADOW, C., PALVIAINEN, T., PAYTON, A., PAZOKI, R., PETROVIC, K., Reynolds, C. A., SARGURUPREMRAJ, M., Scholz, M., Smith, J. A., SMITH, A. V., TERZIKHAN, N., THALAMUTHU, A., TROMPET, S., VAN DER LEE, S. J., WARE, E. B., WINDHAM, B. G., WRIGHT, M. J., Yang, J., Yu, J., Ames, D., Amin, N., Amouyel, P., ANDREASSEN, O. A., ARMSTRONG, N. J., ASSAREH, A. A., ATTIA, J. R., ATTIX, D., AVRAMOPOULOS, D., BENNETT, D. A., BOHMER, A. C., BOYLE, P. A., BRODATY, H., Campbell, H., CANNON, T. D., CIRULLI, E. T., CONGDON, E., CONLEY, E. D., CORLEY, J., COX, S. R., DALE, A. M., DEHGHAN, A., Dick, D., Dickinson, D., ERIKSSON, J. G., EVANGELOU, E., FAUL, J. D., Ford, I., FREIMER, N. A., Gao, H., Giegling, I., GILLESPIE, N. A., GORDON, S. D., GOTTESMAN, R. F., GRISWOLD, M. E., GUDNASON, V., HARRIS, T. B., HARTMANN, A. M., Hatzimanolis, A., Heiss, G., HOLLIDAY, E. G., Joshi, P. K., KAHONEN, M., KARDIA, S. L. R., KARLSSON, I., KLEINEIDAM, L., KNOPMAN, D. S., KOCHAN, N. A., Konte, B., KWOK, J. B., LE HELLARD, S., Lee, T., LEHTIMAKI, T., Li, S. C., Lill, C. M., Liu, T., KOINI, M., London, E., LONGSTRETH, W. T., Jr., LOPEZ, O. L., LOUKOLA, A., LUCK, T., LUNDERVOLD, A. J., LUNDQUIST, A., LYYTIKAINEN, L. P., Martin, N. G., MONTGOMERY, G. W., MURRAY, A. D., NEED, A. C., NOORDAM, R., Nyberg, L., OLLIER, W., PAPENBERG, G., PATTIE, A., POLASEK, O., POLDRACK, R. A., PSATY, B. M., REPPERMUND, S., RIEDEL-HELLER, S. G., ROSE, R. J., ROTTER, J. I., ROUSSOS, P., ROVIO, S. P., SABA, Y., SABB, F. W., SACHDEV, P. S., SATIZABAL, C. L., Schmid, M., Scott, R. J., SCULT, M. A., SIMINO, J., SLAGBOOM, P. E., SMYRNIS, N., Soumare, A., Stefanis, N. C., STOTT, D. J., STRAUB, R. E., SUNDET, K., Taylor, A. M., TAYLOR, K. D., TZOULAKI, I., Tzourio, C., Uitterlinden, A., Vitart, V., VOINESKOS, A. N., Kaprio, J., Wagner, M., Wagner, H., WEINHOLD, L., WEN, K. H., WIDEN, E., Yang, Q., Zhao, W., ADAMS, H. H. H., ARKING, D. E., Bilder, R. M., BITSIOS, P., BOERWINKLE, E., CHIBA-FALEK, O., Corvin, A., DE JAGER, P. L., Debette, S., Donohoe, G., Elliott, P., FITZPATRICK, A. L., Gill, M., GLAHN, D. C., HAGG, S., HANSELL, N. K., HARIRI, A. R., Ikram, M. A., JUKEMA, J. W., VUOKSIMAA, E., KELLER, M. C., KREMEN, W. S., LAUNER, L., LINDENBERGER, U., Palotie, A., PEDERSEN, N. L., PENDLETON, N., PORTEOUS, D. J., RAIKKONEN, K., RAITAKARI, O. T., Ramirez, A., REINVANG, I., RUDAN, I., DAN, Rujescu, Schmidt, R., Schmidt, H., SCHOFIELD, P. W., STARR, J. M., STEEN, V. M., TROLLOR, J. N., TURNER, S. T., VAN DUIJN, C. M., VILLRINGER, A., WEINBERGER, D. R., WEIR, D. R., WILSON, J. F., Malhotra, A., MCINTOSH, A. M., GALE, C. R., SESHADRI, S., MOSLEY, T. H., Jr., BRESSLER, J., Lencz, T., DEARY, I. J., Bordeaux population health (BPH), and Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
VINTAGE, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, HEALTHY, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract

Christina M. Lill, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this article. This has now been corrected in both the PDF and HTML versions of the article.

Published
2019
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22. How do controls impact trust in the employer?

Author

Weibel, A., den Hartog, D.N., Gillespie, N., Searle, R., Six, F.E., Skinner, D., Work and Organizational Psychology, Political Science and Public Administration, and New Public Governance (NPG)

Subjects
Governance for Society
Abstract

Do organizational controls facilitate or hinder employees' trust in their organization? We addressed this question through a mixed-methods design using three studies. Based on a literature review and an open-response survey study (Study 1), we developed a theoretical model proposing that organizational control is positively related to employees' trust in their organization, and that this relationship is mediated by procedural fairness and organizational prestige. This mediated model was tested and supported in a quantitative survey of 582 European managers and professional employees from a range of organizations (Study 2). A complementary, qualitative interview-based study (Study 3) confirmed that well-implemented controls facilitate trust in the organization; however, poorly implemented control systems that are inconsistent, overly rigid, or incentivize untrustworthy behavior can undermine trust in the organization. © 2015 Wiley Periodicals, Inc.

Published
2016
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26. Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Author

Davies, G., Lam, M., Harris, S. E., Trampush, J. W., Luciano, M., Hill, W. D., Hagenaars, S. P., Ritchie, S. J., Marioni, R. E., Fawns-Ritchie, C., Liewald, D. C. M., Okely, J. A., Ahola-Olli, A. V., Barnes, C. L. K., Bertram, L., Bis, J. C., Burdick, K. E., Christoforou, A., Derosse, P., Djurovic, S., Espeseth, T., Giakoumaki, S., Giddaluru, S., Gustavson, D. E., Hayward, C., Hofer, E., Ikram, M. A., Karlsson, R., Knowles, E., Lahti, J., Leber, M., Li, S., Mather, K. A., Melle, I., Morris, D., Oldmeadow, C., Palviainen, T., Payton, A., Pazoki, R., Petrovic, K., Reynolds, C. A., Sargurupremraj, M., Scholz, M., Smith, J. A., Smith, A. V., Terzikhan, N., Thalamuthu, A., Trompet, S., Van Der Lee, S. J., Ware, E. B., Windham, B. G., Wright, M. J., Yang, J., Yu, J., Ames, D., Amin, N., Amouyel, P., Andreassen, O. A., Armstrong, N. J., Assareh, A. A., Attia, J. R., Attix, D., Avramopoulos, D., Bennett, D. A., Böhmer, A. C., Boyle, P. A., Brodaty, H., Campbell, H., Cannon, T. D., Cirulli, E. T., Congdon, E., Conley, E. D., Corley, J., Cox, S. R., Dale, A. M., Dehghan, A., Dick, D., Dickinson, D., Eriksson, J. G., Evangelou, E., Faul, J. D., Ford, I., Freimer, N. A., Gao, H., Giegling, I., Gillespie, N. A., Gordon, S. D., Gottesman, R. F., Griswold, M. E., Gudnason, V., Harris, T. B., Hartmann, A. M., Hatzimanolis, A., Heiss, G., Holliday, E. G., Joshi, P. K., Kähönen, M., Kardia, S. L. R., Karlsson, Ida K., Kleineidam, L., Knopman, D. S., Kochan, N. A., Konte, B., Kwok, J. B., Le Hellard, S., Lee, T., Lehtimäki, T., Li, S. -C, Liu, T., Koini, M., London, E., Longstreth, W.T., Jr., Lopez, O. L., Loukola, A., Luck, T., Lundervold, A. J., Lundquist, A., Lyytikäinen, L. -P, Martin, N. G., Montgomery, G. W., Murray, A. D., Need, A. C., Noordam, R., Nyberg, L., Ollier, W., Papenberg, G., Pattie, A., Polasek, O., Poldrack, R. A., Psaty, B. M., Reppermund, S., Riedel-Heller, S. G., Rose, R. J., Rotter, J. I., Roussos, P., Rovio, S. P., Saba, Y., Sabb, F. W., Sachdev, P. S., Satizabal, C. L., Schmid, M., Scott, R. J., Scult, M. A., Simino, J., Slagboom, P. E., Smyrnis, N., Soumaré, A., Stefanis, N. C., Stott, D. J., Straub, R. E., Sundet, K., Taylor, A. M., Taylor, K. D., Tzoulaki, I., Tzourio, C., Uitterlinden, A., Vitart, V., Voineskos, A. N., Kaprio, J., Wagner, M., Wagner, H., Weinhold, L., Wen, K. H., Widen, E., Yang, Q., Zhao, W., Adams, H. H. H., Arking, D. E., Bilder, R. M., Bitsios, P., Boerwinkle, E., Chiba-Falek, O., Corvin, A., De Jager, P. L., Debette, S., Donohoe, G., Elliott, P., Fitzpatrick, A. L., Gill, M., Glahn, D. C., Hägg, S., Hansell, N. K., Hariri, A. R., Ikram, M. K., Jukema, J. W., Vuoksimaa, E., Keller, M. C., Kremen, W. S., Launer, L., Lindenberger, U., Palotie, A., Pedersen, N. L., Pendleton, N., Porteous, D. J., Räikkönen, K., Raitakari, O. T., Ramirez, A., Reinvang, I., Rudan, I., Rujescu, D., Schmidt, R., Schmidt, H., Schofield, P. W., Schofield, P. R., Starr, J. M., Steen, V. M., Trollor, J. N., Turner, S. T., Van Duijn, C. M., Villringer, A., Weinberger, D. R., Weir, D. R., Wilson, J. F., Malhotra, A., McIntosh, A. M., Gale, C. R., Seshadri, S., Mosley, T.H., Jr., Bressler, J., Lencz, T., Deary, I. J., Davies, G., Lam, M., Harris, S. E., Trampush, J. W., Luciano, M., Hill, W. D., Hagenaars, S. P., Ritchie, S. J., Marioni, R. E., Fawns-Ritchie, C., Liewald, D. C. M., Okely, J. A., Ahola-Olli, A. V., Barnes, C. L. K., Bertram, L., Bis, J. C., Burdick, K. E., Christoforou, A., Derosse, P., Djurovic, S., Espeseth, T., Giakoumaki, S., Giddaluru, S., Gustavson, D. E., Hayward, C., Hofer, E., Ikram, M. A., Karlsson, R., Knowles, E., Lahti, J., Leber, M., Li, S., Mather, K. A., Melle, I., Morris, D., Oldmeadow, C., Palviainen, T., Payton, A., Pazoki, R., Petrovic, K., Reynolds, C. A., Sargurupremraj, M., Scholz, M., Smith, J. A., Smith, A. V., Terzikhan, N., Thalamuthu, A., Trompet, S., Van Der Lee, S. J., Ware, E. B., Windham, B. G., Wright, M. J., Yang, J., Yu, J., Ames, D., Amin, N., Amouyel, P., Andreassen, O. A., Armstrong, N. J., Assareh, A. A., Attia, J. R., Attix, D., Avramopoulos, D., Bennett, D. A., Böhmer, A. C., Boyle, P. A., Brodaty, H., Campbell, H., Cannon, T. D., Cirulli, E. T., Congdon, E., Conley, E. D., Corley, J., Cox, S. R., Dale, A. M., Dehghan, A., Dick, D., Dickinson, D., Eriksson, J. G., Evangelou, E., Faul, J. D., Ford, I., Freimer, N. A., Gao, H., Giegling, I., Gillespie, N. A., Gordon, S. D., Gottesman, R. F., Griswold, M. E., Gudnason, V., Harris, T. B., Hartmann, A. M., Hatzimanolis, A., Heiss, G., Holliday, E. G., Joshi, P. K., Kähönen, M., Kardia, S. L. R., Karlsson, Ida K., Kleineidam, L., Knopman, D. S., Kochan, N. A., Konte, B., Kwok, J. B., Le Hellard, S., Lee, T., Lehtimäki, T., Li, S. -C, Liu, T., Koini, M., London, E., Longstreth, W.T., Jr., Lopez, O. L., Loukola, A., Luck, T., Lundervold, A. J., Lundquist, A., Lyytikäinen, L. -P, Martin, N. G., Montgomery, G. W., Murray, A. D., Need, A. C., Noordam, R., Nyberg, L., Ollier, W., Papenberg, G., Pattie, A., Polasek, O., Poldrack, R. A., Psaty, B. M., Reppermund, S., Riedel-Heller, S. G., Rose, R. J., Rotter, J. I., Roussos, P., Rovio, S. P., Saba, Y., Sabb, F. W., Sachdev, P. S., Satizabal, C. L., Schmid, M., Scott, R. J., Scult, M. A., Simino, J., Slagboom, P. E., Smyrnis, N., Soumaré, A., Stefanis, N. C., Stott, D. J., Straub, R. E., Sundet, K., Taylor, A. M., Taylor, K. D., Tzoulaki, I., Tzourio, C., Uitterlinden, A., Vitart, V., Voineskos, A. N., Kaprio, J., Wagner, M., Wagner, H., Weinhold, L., Wen, K. H., Widen, E., Yang, Q., Zhao, W., Adams, H. H. H., Arking, D. E., Bilder, R. M., Bitsios, P., Boerwinkle, E., Chiba-Falek, O., Corvin, A., De Jager, P. L., Debette, S., Donohoe, G., Elliott, P., Fitzpatrick, A. L., Gill, M., Glahn, D. C., Hägg, S., Hansell, N. K., Hariri, A. R., Ikram, M. K., Jukema, J. W., Vuoksimaa, E., Keller, M. C., Kremen, W. S., Launer, L., Lindenberger, U., Palotie, A., Pedersen, N. L., Pendleton, N., Porteous, D. J., Räikkönen, K., Raitakari, O. T., Ramirez, A., Reinvang, I., Rudan, I., Rujescu, D., Schmidt, R., Schmidt, H., Schofield, P. W., Schofield, P. R., Starr, J. M., Steen, V. M., Trollor, J. N., Turner, S. T., Van Duijn, C. M., Villringer, A., Weinberger, D. R., Weir, D. R., Wilson, J. F., Malhotra, A., McIntosh, A. M., Gale, C. R., Seshadri, S., Mosley, T.H., Jr., Bressler, J., Lencz, T., and Deary, I. J.

Abstract

General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P < 5 × 10-8) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function.

Published
2018
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29. Size matters; but so does what you do with it! Response

Author

Schmaal, L., Veltman, D. J., van Erp, T. G. M., Saemann, P. G., Frodl, T., Jahanshad, N., Loehrer, E., Vernooij, M. W., Niessen, W. J., Ikram, M. A., Wittfeld, K., Grabe, H. J., Block, A., Hegenscheid, K., Hoehn, D., Czisch, M., Lagopoulos, J., Hatton, S. N., Hickie, I. B., Goya-Maldonado, R., Kraemer, B., Gruber, O., Couvy-Duchesne, B., Renteria, M. E., Strike, L. T., Wright, M. J., de Zubicaray, G. I., McMahon, K. L., Medland, S. E., Gillespie, N. A., Hall, G. B., van Velzen, L. S., van Tol, M-J, van der Wee, N. J., Veer, I. M., Walter, H., Schramm, E., Normann, C., Schoepf, D., Konrad, C., Zurowski, B., McIntosh, A. M., Whalley, H. C., Sussmann, J. E., Godlewska, B. R., Fischer, F. H., Penninx, B. W. J. H., Thompson, P. M., Hibar, D. P., Psychiatry, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, and Anatomy and neurosciences

Published
2016
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30. Response to: Size matters; but so does what you do with it!

Author

Schmaal, L., Veltman, D.J., van Erp, T. G. M., Saemann, P. G., Frodl, T., Jahanshad, N., Loehrer, E., Vernooij, M. W., Niessen, W. J., Ikram, M. A., Wittfeld, K., Grabe, H. J., Block, A., Hegenscheid, K., Hoehn, D., Czisch, M., Lagopoulos, J., Hatton, S. N., Hickie, I. B., Goya-Maldonado, R., Kraemer, B., Gruber, O., Couvy-Duchesne, B., Renteria, M. E., Strike, L. T., Wright, M. J., de Zubicaray, G. I., McMahon, K. L., Medland, S. E., Gillespie, N. A., Hall, G B, van Velzen, L. S., van Tol, M-J., van der Wee, N. J., Veer, I. M., Walter, H., Schramm, E., Normann, C., Schoepf, D., Konrad, C., Zurowski, B., McIntosh, A. M., Whalley, H. C., Sussmann, J. E., Godlewska, B. R., Fischer, F. H., Penninx, B. W. J. H., Thompson, P. M., Hibar, D. P., Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), and Clinical Cognitive Neuropsychiatry Research Program (CCNP)

Subjects
MAJOR DEPRESSIVE DISORDER, HISTORY, EARLY-ONSET, ANXIETY
Published
2016

31. Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium

Author

Stringer, S., Minică, C. C., Verweij, K. J.H., Mbarek, Hamdi, Bernard, M., Derringer, Jaime, van Eijk, K. R., Isen, J. D., Loukola, Anu, Maciejewski, D. F., Mihailov, E., van der Most, Peter J., Sánchez-Mora, C., Roos, L., Sherva, R., Walters, R.G., Ware, James S., Abdellaoui, A., Bigdeli, T. B., Branje, S. J.T., Brown, A.S., Bruinenberg, M., Casas, M., Esko, Tonu, Garcia-Martinez, I., Gordon, Scott D., Harris, Juliette M, Hartman, Catharine A, Henders, Anjali K., Heath, Andrew C., Hickie, Ian B., Hickman, M., Hopfer, C. J., Hottenga, J.J., Huizink, A.C., Irons, D. E., Kahn, R. S., Korhonen, T.K., Kranzler, H. R., Krauter, K., van Lier, P.A.C., Lubke, G.H., Madden, Pamela A. F., Mägi, Reedik, McGue, M. K., Medland, Sarah E., Meeus, W.H.J., Miller, Michael B., Montgomery, Grant W., Nivard, Michel G, Nolte, Ilja M., Oldehinkel, Albertine J., Pausova, Zdenka, Qaiser, B., Quaye, Lydia, Ramos-Quiroga, J. A., Richarte, V., Rose, R.J., Shin, J.J., Stallings, M. C., Stiby, A. I., Wall, T. L., Wright, Margaret J., Koot, H.M., Paus, T., Hewitt, J. K., Ribasés, M., Kaprio, Jaakko, Boks, M. P., Snieder, H., Spector, T.D., Munafò, M. R., Metspalu, A., Gelernter, J., Boomsma, Dorret I., Iacono, William G, Martin, Nicholas G., Gillespie, N. A., Derks, Eske M., and Vink, J. M.

Subjects
Cellular and Molecular Neuroscience, Psychiatry and Mental health, Research Support, N.I.H., Extramural, Journal Article, Biological Psychiatry, Research Support, U.S. Gov't, Non-P.H.S, Meta-Analysis
Abstract

Cannabis is the most widely produced and consumed illicit psychoactive substance worldwide. Occasional cannabis use can progress to frequent use, abuse and dependence with all known adverse physical, psychological and social consequences. Individual differences in cannabis initiation are heritable (40-48%). The International Cannabis Consortium was established with the aim to identify genetic risk variants of cannabis use. We conducted a meta-analysis of genome-wide association data of 13 cohorts (N=32 330) and four replication samples (N=5627). In addition, we performed a gene-based test of association, estimated single-nucleotide polymorphism (SNP)-based heritability and explored the genetic correlation between lifetime cannabis use and cigarette use using LD score regression. No individual SNPs reached genome-wide significance. Nonetheless, gene-based tests identified four genes significantly associated with lifetime cannabis use: NCAM1, CADM2, SCOC and KCNT2. Previous studies reported associations of NCAM1 with cigarette smoking and other substance use, and those of CADM2 with body mass index, processing speed and autism disorders, which are phenotypes previously reported to be associated with cannabis use. Furthermore, we showed that, combined across the genome, all common SNPs explained 13-20% (P

Published
2016

32. Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium

Author

Stringer, S, Minică, C C, Verweij, K J H, Mbarek, H, Bernard, M, Derringer, J, van Eijk, K R, Isen, J D, Loukola, A, Maciejewski, D F, Mihailov, E, van der Most, P J, Sánchez-Mora, C, Roos, L, Sherva, R, Walters, R, Ware, J J, Abdellaoui, A, Bigdeli, T B, Branje, S J T, Brown, S A, Bruinenberg, M, Casas, M, Esko, T, Garcia-Martinez, I, Gordon, S D, Harris, J M, Hartman, C A, Henders, A K, Heath, A C, Hickie, Ian B, Hickman, M, Hopfer, C J, Hottenga, J J, Huizink, A C, Irons, D E, Kahn, R S, Korhonen, T, Kranzler, H R, Krauter, K, van Lier, P A C, Lubke, G H, Madden, P A F, Mägi, R, McGue, M K, Medland, S E, Meeus, W H J, Miller, M B, Montgomery, G W, Nivard, M G, Nolte, I M, Oldehinkel, A J, Pausova, Z, Qaiser, B, Quaye, L, Ramos-Quiroga, J A, Richarte, V, Rose, R J, Shin, J, Stallings, M C, Stiby, A I, Wall, T L, Wright, M J, Koot, H M, Paus, T, Hewitt, J K, Ribasés, M, Kaprio, J, Boks, M P, Snieder, Harold, Spector, T, Munafò, M R, Metspalu, A, Gelernter, J, Boomsma, D I, Iacono, W G, Martin, N G, Gillespie, N A, Derks, E M, Vink, J M, and Universitat Autònoma de Barcelona

Abstract

Cannabis is the most widely produced and consumed illicit psychoactive substance worldwide. Occasional cannabis use can progress to frequent use, abuse and dependence with all known adverse physical, psychological and social consequences. Individual differences in cannabis initiation are heritable (40-48%). The International Cannabis Consortium was established with the aim to identify genetic risk variants of cannabis use. We conducted a meta-analysis of genome-wide association data of 13 cohorts (N =32 330) and four replication samples (N =5627). In addition, we performed a gene-based test of association, estimated single-nucleotide polymorphism (SNP)-based heritability and explored the genetic correlation between lifetime cannabis use and cigarette use using LD score regression. No individual SNPs reached genome-wide significance. Nonetheless, gene-based tests identified four genes significantly associated with lifetime cannabis use: NCAM1, CADM2, SCOC and KCNT2. Previous studies reported associations of NCAM1 with cigarette smoking and other substance use, and those of CADM2 with body mass index, processing speed and autism disorders, which are phenotypes previously reported to be associated with cannabis use. Furthermore, we showed that, combined across the genome, all common SNPs explained 13-20% (P

Published
2016

34. Hair cortisol in twins:heritability and genetic overlap with psychological variables and stress-system genes

Author

Rietschel, L. (Liz), Streit, F. (Fabian), Zhu, G. (Gu), McAlone, K. (Kerrie), Frank, J. (Josef), Couvy-Duchesne, B. (Baptiste), Witt, S. H. (Stephanie H.), Binz, T. M. (Tina M.), McGrath, J. (John), Hickie, I. B. (Ian B.), Hansel, N. K. (Narelle K.), Wright, M. J. (Margaret J.), Gillespie, N. A. (Nathan A.), Forstner, A. J. (Andreas J.), Schulze, T. G. (Thomas G.), Wüst, S. (Stefan), Nöthen, M. M. (Markus M.), Baumgartner, M. R. (Markus R.), Walker, B. R. (Brian R.), Crawford, A. A. (Andrew A.), Colodro-Conde, L. (Lucía), Medland, S. E. (Sarah E.), Martin, N. G. (Nicholas G.), Rietschel, M. (Marcella), Rietschel, L. (Liz), Streit, F. (Fabian), Zhu, G. (Gu), McAlone, K. (Kerrie), Frank, J. (Josef), Couvy-Duchesne, B. (Baptiste), Witt, S. H. (Stephanie H.), Binz, T. M. (Tina M.), McGrath, J. (John), Hickie, I. B. (Ian B.), Hansel, N. K. (Narelle K.), Wright, M. J. (Margaret J.), Gillespie, N. A. (Nathan A.), Forstner, A. J. (Andreas J.), Schulze, T. G. (Thomas G.), Wüst, S. (Stefan), Nöthen, M. M. (Markus M.), Baumgartner, M. R. (Markus R.), Walker, B. R. (Brian R.), Crawford, A. A. (Andrew A.), Colodro-Conde, L. (Lucía), Medland, S. E. (Sarah E.), Martin, N. G. (Nicholas G.), and Rietschel, M. (Marcella)

Abstract

Hair cortisol concentration (HCC) is a promising measure of long-term hypothalamus-pituitary-adrenal (HPA) axis activity. Previous research has suggested an association between HCC and psychological variables, and initial studies of inter-individual variance in HCC have implicated genetic factors. However, whether HCC and psychological variables share genetic risk factors remains unclear. The aims of the present twin study were to: (i) assess the heritability of HCC; (ii) estimate the phenotypic and genetic correlation between HPA axis activity and the psychological variables perceived stress, depressive symptoms, and neuroticism; using formal genetic twin models and molecular genetic methods, i.e. polygenic risk scores (PRS). HCC was measured in 671 adolescents and young adults. These included 115 monozygotic and 183 dizygotic twin-pairs. For 432 subjects PRS scores for plasma cortisol, major depression, and neuroticism were calculated using data from large genome wide association studies. The twin model revealed a heritability for HCC of 72%. No significant phenotypic or genetic correlation was found between HCC and the three psychological variables of interest. PRS did not explain variance in HCC. The present data suggest that HCC is highly heritable. However, the data do not support a strong biological link between HCC and any of the investigated psychological variables., Consortia CORtisolNETwork (CORNET) Consortium Jennifer L. Bolton21 Caroline Hayward23 Nese Direk24,25 Anna Anderson21 Jennifer Huffman23 James F. Wilson26 Harry Campbell26 Igor Rudan26 Alan Wright23 Nicholas Hastie23 Sarah H. Wild26 Fleur P. Velders24 Albert Hofman24 Andre G. Uitterlinden24,27 Jari Lahti28 Katri Räikkönen28 Eero Kajantie29 Elisabeth Widen30 Aarno Palotie30,31 Johan G. Eriksson29,32,33,34,35 Marika Kaakinen36 Marjo-Riitta Järvelin36,37,38,39 Nicholas J. Timpson40 George Davey Smith40 Susan M. Ring41 David M. Evans40 Beate St Pourcain41 Toshiko Tanaka42 Yuri Milaneschi42,43 Stefania Bandinelli44 Luigi Ferrucci42 Pim van der Harst45,46,47 Judith GM Rosmalen48 Stephen JL Bakker49 Niek Verweij45 Robin PF Dullaart49 Anubha Mahajan50 Cecilia M. Lindgren50 Andrew Morris50 Lars Lind51 Erik Ingelsson51 Laura N. Anderson52 Craig E. Pennell53 Stephen J. Lye52 Stephen G. Matthews54 Joel Eriksson55 Dan Mellstrom55 Claes Ohlsson55 Jackie F. Price26 Mark WJ Strachan21 Rebecca M. Reynolds21 Henning Tiemeier24,56,57 Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (PGC) Stephan Ripke58,59,60 Manuel Mattheisen61,62,63 Abdel Abdellaoui64 Mark J. Adams65 Esben Agerbo66,8,67 Tracy M. Air68 Till FM Andlauer69,70 Silviu-Alin Bacanu71 Marie Bækvad-Hansen67,72 Aartjan TF Beekman43 David A. Bennett73 Klaus Berger74 Tim B. Bigdeli71,11 Jonas Bybjerg-Grauholm67,72 Enda M. Byrne5 Na Cai75 Enrique Castelao76 Toni-Kim Clarke65 Jonathan RI Coleman77 Converge Consortium78 Nick Craddock79 Udo Dannlowski80,81 Gareth Davies82 Gail Davies83 Eco. J. C. de Geus64,84 Philip De Jager85 Ian J. Deary83 Franziska Degenhardt12,13 Erin C. Dunn86,87,88 Erik A. Ehli82 Thalia C. Eley77 Valentina Escott-Price89 Tõnu Esko58,90,91,92 Hilary K. Finucane93,94 Michael Gill95 Scott D. Gordon96 Jakob Grove61,62,67,97 Lynsey S. Hall65,98 Thomas F. Hansen99,100 Christine Søholm Hansen67,72 Thomas F. Hansen101 Andrew C. Heath102 Anjali K. Henders5 Stefan Herms12,13,15 Per Hoffman

Published
2017

36. Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32330 subjects from the International Cannabis Consortium

Author

University of Helsinki, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Clinicum, Stringer, S., Minica, C. C., Verweij, K. J. H., Mbarek, H., Bernard, M., Derringer, J., van Eijk, K. R., Isen, J. D., Loukola, A., Maciejewski, D. F., Mihailov, E., van der Most, P. J., Sanchez-Mora, C., Roos, L., Sherva, R., Walters, R., Ware, J. J., Abdellaoui, A., Bigdeli, T. B., Branje, S. J. T., Brown, S. A., Bruinenberg, M., Casas, M., Esko, T., Garcia-Martinez, I., Gordon, S. D., Harris, J. M., Hartman, C. A., Henders, A. K., Heath, A. C., Hickie, I. B., Hickman, M., Hopfer, C. J., Hottenga, J. J., Huizink, A. C., Irons, D. E., Kahn, R. S., Korhonen, T., Kranzler, H. R., Krauter, K., van Lier, P. A. C., Lubke, G. H., Madden, P. A. F., Magi, R., McGue, M. K., Medland, S. E., Meeus, W. H. J., Miller, M. B., Montgomery, G. W., Nivard, M. G., Nolte, I. M., Oldehinkel, A. J., Pausova, Z., Qaiser, B., Quaye, L., Ramos-Quiroga, J. A., Richarte, V., Rose, R. J., Shin, J., Stallings, M. C., Stiby, A. I., Wall, T. L., Wright, M. J., Koot, H. M., Paus, T., Hewitt, J. K., Ribases, M., Kaprio, J., Boks, M. P., Snieder, H., Spector, T., Munafo, M. R., Metspalu, A., Gelernter, J., Boomsma, D. I., Iacono, W. G., Martin, N. G., Gillespie, N. A., Derks, E. M., Vink, J. M., University of Helsinki, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Clinicum, Stringer, S., Minica, C. C., Verweij, K. J. H., Mbarek, H., Bernard, M., Derringer, J., van Eijk, K. R., Isen, J. D., Loukola, A., Maciejewski, D. F., Mihailov, E., van der Most, P. J., Sanchez-Mora, C., Roos, L., Sherva, R., Walters, R., Ware, J. J., Abdellaoui, A., Bigdeli, T. B., Branje, S. J. T., Brown, S. A., Bruinenberg, M., Casas, M., Esko, T., Garcia-Martinez, I., Gordon, S. D., Harris, J. M., Hartman, C. A., Henders, A. K., Heath, A. C., Hickie, I. B., Hickman, M., Hopfer, C. J., Hottenga, J. J., Huizink, A. C., Irons, D. E., Kahn, R. S., Korhonen, T., Kranzler, H. R., Krauter, K., van Lier, P. A. C., Lubke, G. H., Madden, P. A. F., Magi, R., McGue, M. K., Medland, S. E., Meeus, W. H. J., Miller, M. B., Montgomery, G. W., Nivard, M. G., Nolte, I. M., Oldehinkel, A. J., Pausova, Z., Qaiser, B., Quaye, L., Ramos-Quiroga, J. A., Richarte, V., Rose, R. J., Shin, J., Stallings, M. C., Stiby, A. I., Wall, T. L., Wright, M. J., Koot, H. M., Paus, T., Hewitt, J. K., Ribases, M., Kaprio, J., Boks, M. P., Snieder, H., Spector, T., Munafo, M. R., Metspalu, A., Gelernter, J., Boomsma, D. I., Iacono, W. G., Martin, N. G., Gillespie, N. A., Derks, E. M., and Vink, J. M.

Abstract

Cannabis is the most widely produced and consumed illicit psychoactive substance worldwide. Occasional cannabis use can progress to frequent use, abuse and dependence with all known adverse physical, psychological and social consequences. Individual differences in cannabis initiation are heritable (40-48%). The International Cannabis Consortium was established with the aim to identify genetic risk variants of cannabis use. We conducted a meta-analysis of genome-wide association data of 13 cohorts (N = 32 330) and four replication samples (N = 5627). In addition, we performed a gene-based test of association, estimated single-nucleotide polymorphism (SNP)-based heritability and explored the genetic correlation between lifetime cannabis use and cigarette use using LD score regression. No individual SNPs reached genome-wide significance. Nonetheless, gene-based tests identified four genes significantly associated with lifetime cannabis use: NCAM1, CADM2, SCOC and KCNT2. Previous studies reported associations of NCAM1 with cigarette smoking and other substance use, and those of CADM2 with body mass index, processing speed and autism disorders, which are phenotypes previously reported to be associated with cannabis use.

Published
2016

37. Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium

Author

Adolescent development: Characteristics and determinants, Afd culturele antropologie, Leerstoel Branje, Leerstoel Meeus, Sub Biomol.Mass Spectrometry & Proteom., Sub High energy Astrophysics begr 1/1/15, Stringer, S, Minică, C C, Verweij, K J H, Mbarek, H, Bernard, M, Derringer, J, van Eijk, K R, Isen, J D, Loukola, A, Maciejewski, Dominique F., Mihailov, E, van der Most, P J, Sánchez-Mora, C, Roos, L, Sherva, R, Walters, R, Ware, J J, Abdellaoui, A, Bigdeli, T B, Branje, S J T, Brown, S A, Bruinenberg, M, Casas, M, Esko, T, Garcia-Martinez, I, Gordon, S D, Harris, J M, Hartman, C A, Henders, A K, Heath, A C, Hickie, I B, Hickman, M, Hopfer, C J, Hottenga, J J, Huizink, A C, Irons, D E, Kahn, R S, Korhonen, T, Kranzler, H R, Krauter, K, van Lier, P A C, Lubke, G H, Madden, P A F, Mägi, R, McGue, M K, Medland, S E, Meeus, W H J, Miller, M B, Montgomery, G W, Nivard, M G, Nolte, I M, Oldehinkel, A J, Pausova, Z, Qaiser, B, Quaye, L, Ramos-Quiroga, J A, Richarte, V, Rose, R J, Shin, J, Stallings, M C, Stiby, A I, Wall, T L, Wright, M J, Koot, H M, Paus, T, Hewitt, J K, Ribasés, M, Kaprio, J, Boks, M P, Snieder, H, Spector, T, Munafò, M R, Metspalu, A, Gelernter, J, Boomsma, D I, Iacono, W G, Martin, N G, Gillespie, N A, Derks, E M, Vink, J M, Adolescent development: Characteristics and determinants, Afd culturele antropologie, Leerstoel Branje, Leerstoel Meeus, Sub Biomol.Mass Spectrometry & Proteom., Sub High energy Astrophysics begr 1/1/15, Stringer, S, Minică, C C, Verweij, K J H, Mbarek, H, Bernard, M, Derringer, J, van Eijk, K R, Isen, J D, Loukola, A, Maciejewski, Dominique F., Mihailov, E, van der Most, P J, Sánchez-Mora, C, Roos, L, Sherva, R, Walters, R, Ware, J J, Abdellaoui, A, Bigdeli, T B, Branje, S J T, Brown, S A, Bruinenberg, M, Casas, M, Esko, T, Garcia-Martinez, I, Gordon, S D, Harris, J M, Hartman, C A, Henders, A K, Heath, A C, Hickie, I B, Hickman, M, Hopfer, C J, Hottenga, J J, Huizink, A C, Irons, D E, Kahn, R S, Korhonen, T, Kranzler, H R, Krauter, K, van Lier, P A C, Lubke, G H, Madden, P A F, Mägi, R, McGue, M K, Medland, S E, Meeus, W H J, Miller, M B, Montgomery, G W, Nivard, M G, Nolte, I M, Oldehinkel, A J, Pausova, Z, Qaiser, B, Quaye, L, Ramos-Quiroga, J A, Richarte, V, Rose, R J, Shin, J, Stallings, M C, Stiby, A I, Wall, T L, Wright, M J, Koot, H M, Paus, T, Hewitt, J K, Ribasés, M, Kaprio, J, Boks, M P, Snieder, H, Spector, T, Munafò, M R, Metspalu, A, Gelernter, J, Boomsma, D I, Iacono, W G, Martin, N G, Gillespie, N A, Derks, E M, and Vink, J M

Published
2016

38. Trust and Team Performance: A Meta-Analysis of Main Effects, Moderators, and Covariates

Author

de Jong, B.A., Dirks, K.T., Gillespie, N., de Jong, B.A., Dirks, K.T., and Gillespie, N.

Abstract

Cumulating evidence from 112 independent studies (N = 7,763 teams), we meta-analytically examine the fundamental questions of whether intrateam trust is positively related to team performance, and the conditions under which it is particularly important. We address these questions by analyzing the overall trust–performance relationship, assessing the robustness of this relationship by controlling for other relevant predictors and covariates, and examining how the strength of this relationship varies as a function of several moderating factors. Our findings confirm that intrateam trust is positively related to team performance, and has an above-average impact (rho = .30). The covariate analyses show that this relationship holds after controlling for team trust in leader and past team performance, and across dimensions of trust (i.e., cognitive and affective). The moderator analyses indicate that the trust–performance relationship is contingent upon the level of task interdependence, authority differentiation, and skill differentiation in teams. Finally, we conducted preliminary analyses on several emerging issues in the literature regarding the conceptualization and measurement of trust and team performance (i.e., referent of intrateam trust, dimension of performance, performance objectivity). Together, our findings contribute to the literature by helping to (a) integrate the field of intrateam trust research, (b) resolve mixed findings regarding the trust–performance relationship, (c) overcome scholarly skepticism regarding the main effect of trust on team performance, and (d) identify the conditions under which trust is most important for team performance.

Published
2016
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39. Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium

Author

Neurogenetica, Brain, Onderzoeksgroep 2, Stringer, S., Minică, C. C., Verweij, K. J.H., Mbarek, Hamdi, Bernard, M., Derringer, Jaime, van Eijk, K. R., Isen, J. D., Loukola, Anu, Maciejewski, D. F., Mihailov, E., van der Most, Peter J., Sánchez-Mora, C., Roos, L., Sherva, R., Walters, R.G., Ware, James S., Abdellaoui, A., Bigdeli, T. B., Branje, S. J.T., Brown, A.S., Bruinenberg, M., Casas, M., Esko, Tonu, Garcia-Martinez, I., Gordon, Scott D., Harris, Juliette M, Hartman, Catharine A, Henders, Anjali K., Heath, Andrew C., Hickie, Ian B., Hickman, M., Hopfer, C. J., Hottenga, J.J., Huizink, A.C., Irons, D. E., Kahn, R. S., Korhonen, T.K., Kranzler, H. R., Krauter, K., van Lier, P.A.C., Lubke, G.H., Madden, Pamela A. F., Mägi, Reedik, McGue, M. K., Medland, Sarah E., Meeus, W.H.J., Miller, Michael B., Montgomery, Grant W., Nivard, Michel G, Nolte, Ilja M., Oldehinkel, Albertine J., Pausova, Zdenka, Qaiser, B., Quaye, Lydia, Ramos-Quiroga, J. A., Richarte, V., Rose, R.J., Shin, J.J., Stallings, M. C., Stiby, A. I., Wall, T. L., Wright, Margaret J., Koot, H.M., Paus, T., Hewitt, J. K., Ribasés, M., Kaprio, Jaakko, Boks, M. P., Snieder, H., Spector, T.D., Munafò, M. R., Metspalu, A., Gelernter, J., Boomsma, Dorret I., Iacono, William G, Martin, Nicholas G., Gillespie, N. A., Derks, Eske M., Vink, J. M., Neurogenetica, Brain, Onderzoeksgroep 2, Stringer, S., Minică, C. C., Verweij, K. J.H., Mbarek, Hamdi, Bernard, M., Derringer, Jaime, van Eijk, K. R., Isen, J. D., Loukola, Anu, Maciejewski, D. F., Mihailov, E., van der Most, Peter J., Sánchez-Mora, C., Roos, L., Sherva, R., Walters, R.G., Ware, James S., Abdellaoui, A., Bigdeli, T. B., Branje, S. J.T., Brown, A.S., Bruinenberg, M., Casas, M., Esko, Tonu, Garcia-Martinez, I., Gordon, Scott D., Harris, Juliette M, Hartman, Catharine A, Henders, Anjali K., Heath, Andrew C., Hickie, Ian B., Hickman, M., Hopfer, C. J., Hottenga, J.J., Huizink, A.C., Irons, D. E., Kahn, R. S., Korhonen, T.K., Kranzler, H. R., Krauter, K., van Lier, P.A.C., Lubke, G.H., Madden, Pamela A. F., Mägi, Reedik, McGue, M. K., Medland, Sarah E., Meeus, W.H.J., Miller, Michael B., Montgomery, Grant W., Nivard, Michel G, Nolte, Ilja M., Oldehinkel, Albertine J., Pausova, Zdenka, Qaiser, B., Quaye, Lydia, Ramos-Quiroga, J. A., Richarte, V., Rose, R.J., Shin, J.J., Stallings, M. C., Stiby, A. I., Wall, T. L., Wright, Margaret J., Koot, H.M., Paus, T., Hewitt, J. K., Ribasés, M., Kaprio, Jaakko, Boks, M. P., Snieder, H., Spector, T.D., Munafò, M. R., Metspalu, A., Gelernter, J., Boomsma, Dorret I., Iacono, William G, Martin, Nicholas G., Gillespie, N. A., Derks, Eske M., and Vink, J. M.

Published
2016

40. Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32330 subjects from the International Cannabis Consortium

Author

Stringer, S., Minica, C. C., Verweij, K. J. H., Mbarek, H., Bernard, M., Derringer, J., van Eijk, K. R., Isen, J. D., Loukola, A., Maciejewski, D. F., Mihailov, E., van der Most, P. J., Sanchez-Mora, C., Roos, L., Sherva, R., Walters, R., Ware, J. J., Abdellaoui, A., Bigdeli, T. B., Branje, S. J. T., Brown, S. A., Bruinenberg, M., Casas, M., Esko, T., Garcia-Martinez, I., Gordon, S. D., Harris, J. M., Hartman, C. A., Henders, A. K., Heath, A. C., Hickie, I. B., Hickman, M., Hopfer, C. J., Hottenga, J. J., Huizink, A. C., Irons, D. E., Kahn, R. S., Korhonen, T., Kranzler, H. R., Krauter, K., van Lier, P. A. C., Lubke, G. H., Madden, P. A. F., Magi, R., McGue, M. K., Medland, S. E., Meeus, W. H. J., Miller, M. B., Montgomery, G. W., Nivard, M. G., Nolte, I. M., Oldehinkel, A. J., Pausova, Z., Qaiser, B., Quaye, L., Ramos-Quiroga, J. A., Richarte, V., Rose, R. J., Shin, J., Stallings, M. C., Stiby, A. I., Wall, T. L., Wright, M. J., Koot, H. M., Paus, T., Hewitt, J. K., Ribases, M., Kaprio, J., Boks, M. P., Snieder, H., Spector, T., Munafo, M. R., Metspalu, A., Gelernter, J., Boomsma, D. I., Iacono, W. G., Martin, N. G., Gillespie, N. A., Derks, E. M., Vink, J. M., Stringer, S., Minica, C. C., Verweij, K. J. H., Mbarek, H., Bernard, M., Derringer, J., van Eijk, K. R., Isen, J. D., Loukola, A., Maciejewski, D. F., Mihailov, E., van der Most, P. J., Sanchez-Mora, C., Roos, L., Sherva, R., Walters, R., Ware, J. J., Abdellaoui, A., Bigdeli, T. B., Branje, S. J. T., Brown, S. A., Bruinenberg, M., Casas, M., Esko, T., Garcia-Martinez, I., Gordon, S. D., Harris, J. M., Hartman, C. A., Henders, A. K., Heath, A. C., Hickie, I. B., Hickman, M., Hopfer, C. J., Hottenga, J. J., Huizink, A. C., Irons, D. E., Kahn, R. S., Korhonen, T., Kranzler, H. R., Krauter, K., van Lier, P. A. C., Lubke, G. H., Madden, P. A. F., Magi, R., McGue, M. K., Medland, S. E., Meeus, W. H. J., Miller, M. B., Montgomery, G. W., Nivard, M. G., Nolte, I. M., Oldehinkel, A. J., Pausova, Z., Qaiser, B., Quaye, L., Ramos-Quiroga, J. A., Richarte, V., Rose, R. J., Shin, J., Stallings, M. C., Stiby, A. I., Wall, T. L., Wright, M. J., Koot, H. M., Paus, T., Hewitt, J. K., Ribases, M., Kaprio, J., Boks, M. P., Snieder, H., Spector, T., Munafo, M. R., Metspalu, A., Gelernter, J., Boomsma, D. I., Iacono, W. G., Martin, N. G., Gillespie, N. A., Derks, E. M., and Vink, J. M.

Abstract

Cannabis is the most widely produced and consumed illicit psychoactive substance worldwide. Occasional cannabis use can progress to frequent use, abuse and dependence with all known adverse physical, psychological and social consequences. Individual differences in cannabis initiation are heritable (40–48%). The International Cannabis Consortium was established with the aim to identify genetic risk variants of cannabis use. We conducted a meta-analysis of genome-wide association data of 13 cohorts (N=32 330) and four replication samples (N=5627). In addition, we performed a gene-based test of association, estimated single-nucleotide polymorphism (SNP)-based heritability and explored the genetic correlation between lifetime cannabis use and cigarette use using LD score regression. No individual SNPs reached genome-wide significance. Nonetheless, gene-based tests identified four genes significantly associated with lifetime cannabis use: NCAM1, CADM2, SCOC and KCNT2. Previous studies reported associations of NCAM1 with cigarette smoking and other substance use, and those of CADM2 with body mass index, processing speed and autism disorders, which are phenotypes previously reported to be associated with cannabis use. Furthermore, we showed that, combined across the genome, all common SNPs explained 13–20% (P<0.001) of the liability of lifetime cannabis use. Finally, there was a strong genetic correlation (rg=0.83; P=1.85 × 10−8) between lifetime cannabis use and lifetime cigarette smoking implying that the SNP effect sizes of the two traits are highly correlated. This is the largest meta-analysis of cannabis GWA studies to date, revealing important new insights into the genetic pathways of lifetime cannabis use. Future functional studies should explore the impact of the identified genes on the biological mechanisms of cannabis use.

Published
2016

41. Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium

Author

Stringer, S, primary, Minică, C C, additional, Verweij, K J H, additional, Mbarek, H, additional, Bernard, M, additional, Derringer, J, additional, van Eijk, K R, additional, Isen, J D, additional, Loukola, A, additional, Maciejewski, D F, additional, Mihailov, E, additional, van der Most, P J, additional, Sánchez-Mora, C, additional, Roos, L, additional, Sherva, R, additional, Walters, R, additional, Ware, J J, additional, Abdellaoui, A, additional, Bigdeli, T B, additional, Branje, S J T, additional, Brown, S A, additional, Bruinenberg, M, additional, Casas, M, additional, Esko, T, additional, Garcia-Martinez, I, additional, Gordon, S D, additional, Harris, J M, additional, Hartman, C A, additional, Henders, A K, additional, Heath, A C, additional, Hickie, I B, additional, Hickman, M, additional, Hopfer, C J, additional, Hottenga, J J, additional, Huizink, A C, additional, Irons, D E, additional, Kahn, R S, additional, Korhonen, T, additional, Kranzler, H R, additional, Krauter, K, additional, van Lier, P A C, additional, Lubke, G H, additional, Madden, P A F, additional, Mägi, R, additional, McGue, M K, additional, Medland, S E, additional, Meeus, W H J, additional, Miller, M B, additional, Montgomery, G W, additional, Nivard, M G, additional, Nolte, I M, additional, Oldehinkel, A J, additional, Pausova, Z, additional, Qaiser, B, additional, Quaye, L, additional, Ramos-Quiroga, J A, additional, Richarte, V, additional, Rose, R J, additional, Shin, J, additional, Stallings, M C, additional, Stiby, A I, additional, Wall, T L, additional, Wright, M J, additional, Koot, H M, additional, Paus, T, additional, Hewitt, J K, additional, Ribasés, M, additional, Kaprio, J, additional, Boks, M P, additional, Snieder, H, additional, Spector, T, additional, Munafò, M R, additional, Metspalu, A, additional, Gelernter, J, additional, Boomsma, D I, additional, Iacono, W G, additional, Martin, N G, additional, Gillespie, N A, additional, Derks, E M, additional, and Vink, J M, additional

Published
2016
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46. Trust in the employer: the role of high-involvement work practices and procedural justice in European organizations

Author

Searle, R., Den Hartog, D.N., Weibel, A., Gillespie, N., Six, F.E., Hatzakis, T., Skinner, D., Searle, R., Den Hartog, D.N., Weibel, A., Gillespie, N., Six, F.E., Hatzakis, T., and Skinner, D.

Abstract

Despite the central role of trust in the organizational sciences, we know little about what makes people trust the organizations they work for. This paper examines the antecedents of employees' trust in their organizations drawing on survey data from over 600 European professional workers and managers. The results revealed direct as well as indirect relationships of both human resource (HR) practices and procedural justice with trust. The relationships of both HR practices and procedural justice with trust were partially mediated by perceptions of organizational trustworthiness (in terms of perceived ability and trustworthy intentions of the organization). Justice and HR practices were also found to interact such that justice forms a stronger predictor of trust in organizations when HR practices are less developed. In addition, employees' dispositional propensity to trust explained significant variance in employee trust in their organization, even when it was controlled in our analysis. The implications of these findings for research and practice are discussed. © 2011 Taylor & Francis.

Published
2011
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48. Conceptual change research and science education practice: A response from educators

Author

Siry, Christina, Horowitz, G, Otulaja, F.S., Gillespie, N, Shady, A, Augustin, L.A., Siry, Christina, Horowitz, G, Otulaja, F.S., Gillespie, N, Shady, A, and Augustin, L.A.

Abstract

We discuss the eight papers in this issue of Cultural Studies of Science Education focusing on the debate over conceptual change in science education and explore the issues that have emerged for us as we consider how conceptual change research relates to our practice as science educators. In presenting our interpretations of this research, we consider the role of participants in the research process and contextual factors in conducting research on science conceptions, and draw implications for the teaching of science.

Published
2008

49. Reflections on Criminal Justice Policy Since the Royal Commission into Aboriginal Deaths in Custody

Author

Gillespie, N., Cunneen, Chris, Faculty of Law, UNSW, Gillespie, N., and Cunneen, Chris, Faculty of Law, UNSW

Abstract

The long list of shocking cases of Aboriginal deaths in custody exposed by the Royal Commission provided a public understanding of the processes of racism in the criminal justice system and Australian society more generally. The stories of the deaths in custody were the incontrovertible stories of institutional racism, of human tragedy and monumental inhumanity. Some cases showed profound callousness, others simple indifference. The current tragedy is that so many of the circumstances leading to deaths in custody, and identified by the RCADIC, are still routine occurrences.At the broadest level, the political conditions of the late 1990s and the new century have not been conducive in Australia to effective reform of the criminal justice system. There is little doubt that we have moved into a more punitive period in relation to criminal justice responses, and whatever impetus there was to reform in the early 1990s has largely evaporated. We see this drift into ‘law and order’ responses manifested in a range of areas including increased police powers, ‘zero tolerance’ style laws which increase the use of arrest for minor offences, greater levels of bail refusal and longer periods of imprisonment for a range of offences. However, on the positive side there has been a renaissance in Indigenous justice institutions. These provide the potential for significant change in the criminal justice system, and an opportunity for greater recognition of the aspirations of Indigenous people.

Published
2007

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