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318 results on '"Gill, Jessica M."'

1. APOE4 and age affect the brain entorhinal cortex structure and blood arachidonic acid and docosahexaenoic acid levels after mild TBI

Author

Aldrich, Gregory, Evans, James E., Davis, Roderick, Jurin, Lucia, Oberlin, Sarah, Niedospial, Daniel, Nkiliza, Aurore, Mullan, Michael, Kenney, Kimbra, Werner, Jr, J. Kent, Edwards, Katie, Gill, Jessica M., Lindsey, Hannah M., Dennis, Emily L., Walker, William C., Wilde, Elisabeth, Crawford, Fiona, and Abdullah, Laila

Published
2024
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2. Are EPB41 and alpha-synuclein diagnostic biomarkers of sport-related concussion? Findings from the NCAA and Department of Defense CARE Consortium

Author

Vorn, Rany, Devoto, Christina, Meier, Timothy B., Lai, Chen, Yun, Sijung, Broglio, Steven P., Mithani, Sara, McAllister, Thomas W., Giza, Christopher C., Kim, Hyung-Suk, Huber, Daniel, Harezlak, Jaroslaw, Cameron, Kenneth L., McGinty, Gerald, Jackson, Jonathan, Guskiewicz, Kevin M., Mihalik, Jason P., Brooks, Alison, Duma, Stefan, Rowson, Steven, Nelson, Lindsay D., Pasquina, Paul, McCrea, Michael A., and Gill, Jessica M.

Published
2023
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3. Feasibility and acceptability for LION, a fully remote, randomized clinical trial within the VA for light therapy to improve sleep in Veterans with and without TBI: An MTBI2 sponsored protocol.

Author

Elliott, Jonathan E., Brewer, Jessica S., Keil, Allison T., Ligman, Brittany R., Bryant-Ekstrand, Mohini D., McBride, Alisha A., Powers, Katherine, Sicard, Savanah J., Twamley, Elizabeth W., O'Neil, Maya E., Hildebrand, Andrea D., Nguyen, Thuan, Morasco, Benjamin J., Gill, Jessica M., Dengler, Bradley A., and Lim, Miranda M.

Abstract

Sleep-wake disturbances frequently present in Veterans with mild traumatic brain injury (mTBI). These TBI-related sleep impairments confer significant burden and commonly exacerbate other functional impairments. Therapies to improve sleep following mTBI are limited and studies in Veterans are even more scarce. In our previous pilot work, morning bright light therapy (MBLT) was found to be a feasible behavioral sleep intervention in Veterans with a history of mTBI; however, this was single-arm, open-label, and non-randomized, and therefore was not intended to establish efficacy. The present study, LION (light vs ion therapy) extends this preliminary work as a fully powered, sham-controlled, participant-masked randomized controlled trial (NCT03968874), implemented as fully remote within the VA (target n = 120 complete). Randomization at 2:1 allocation ratio to: 1) active: MBLT (n = 80), and 2) sham: deactivated negative ion generator (n = 40); each with identical engagement parameters (60-min duration; within 2-hrs of waking; daily over 28-day duration). Participant masking via deception balanced expectancy assumptions across arms. Outcome measures were assessed following a 14-day baseline (pre-intervention), following 28-days of device engagement (post-intervention), and 28-days after the post-intervention assessment (follow-up). Primary outcomes were sleep measures, including continuous wrist-based actigraphy, self-report, and daily sleep dairy entries. Secondary/exploratory outcomes included cognition, mood, quality of life, circadian rhythm via dim light melatonin onset, and biofluid-based biomarkers. Participant drop out occurred in <10% of those enrolled, incomplete/missing data was present in <15% of key outcome variables, and overall fidelity adherence to the intervention was >85%, collectively establishing feasibility and acceptability for MBLT in Veterans with mTBI. [ABSTRACT FROM AUTHOR]

Published
2025
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4. Research Letter: Relationship of Blood Biomarkers of Inflammation With Acute Concussion Symptoms and Recovery in the CARE Consortium.

Author

Meier, Timothy B., Huber, Daniel L., Goeckner, Bryna D., Gill, Jessica M., Pasquina, Paul, Broglio, Steven P., McAllister, Thomas W., Harezlak, Jaroslaw, and McCrea, Michael A.

Abstract

Objective: Determine the association of inflammatory biomarkers with clinical measures and recovery in participants with concussion. Setting: Multicenter study in National Collegiate Athletic Association member institutions including military service academies. Participants: Four hundred twenty-two participants with acute concussion. Design: Clinical visits and blood draws were completed preinjury and at multiple visits postconcussion (0-12 hours, 12-36 hours, and 36-60 hours postinjury). Clinical measures included Sport Concussion Assessment Tool (SCAT) symptom severity, Balance Error Scoring System, Standardized Assessment of Concussion (SAC), Brief Symptom Inventory-18 (BSI-18) scores, time to initiation of graduated return-to-play (RTP) protocol, and time to RTP. Interleukin (IL)-6, IL-10, IL-8, IL-1 receptor antagonist (RA), tumor necrosis factor (TNF), c-reactive protein, and vascular endothelial growth factor (VEGF) were measured in serum. Prespecified analyses focused on IL-6 and IL-1RA at 0 to 12 hours; exploratory analyses were conducted with false discovery rate correction. Results: For prespecified analyses, IL-1RA at 0 to 12 hours in female participants was positively associated with more errors on the SAC (B(standard error, SE) = 0.58(0.27), P < .05) and worse SCAT symptom severity (B(SE) = 0.96(0.44), P < .05). For exploratory analyses, higher levels of IL-1RA at 12 to 36 hours were associated with higher global (B(SE) = 0.55(0.14), q < 0.01), depression (B(SE) = 0.45(0.10), q < 0.005), and somatization scores on the BSI (B(SE) = 0.46(0.12), q < 0.01) in participants with concussion; Higher TNF at 12 to 36 hours was associated with fewer errors on the SAC (B(SE) = − 0.46(0.14), q < 0.05). Subanalyses showed similar results for male participants and participants who were athletes. No associations were discovered in nonathlete cadets. Higher IL-8 at 0 to 12 hours was associated with slower RTP in female participants (OR = 14.47; 95% confidence interval, 2.96-70.66, q < 0.05); no other associations with recovery were observed. Conclusions: Peripheral inflammatory markers are associated with clinical symptoms following concussion and potentially represent one mechanism for psychological symptoms observed postinjury. Current results do not provide strong support for a potential prognostic role for these markers. [ABSTRACT FROM AUTHOR]

Published
2025
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5. Extracellular vesicle neurofilament light is elevated within the first 12-months following traumatic brain injury in a U.S military population

Author

Guedes, Vivian A., Lange, Rael T., Lippa, Sara M., Lai, Chen, Greer, Kisha, Mithani, Sara, Devoto, Christina, A. Edwards, Katie, Wagner, Chelsea L., Martin, Carina A., Driscoll, Angela E., Wright, Megan M., Gillow, Kelly C., Baschenis, Samantha M., Brickell, Tracey A., French, Louis M., and Gill, Jessica M.

Published
2022
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9. 17α-Ethinyl estradiol-3-sulfate increases survival and hemodynamic functioning in a large animal model of combined traumatic brain injury and hemorrhagic shock: a randomized control trial

Author

Mayer, Andrew R., Dodd, Andrew B., Rannou-Latella, Julie G., Stephenson, David D., Dodd, Rebecca J., Ling, Josef M., Mehos, Carissa J., Robertson-Benta, Cidney R., Pabbathi Reddy, Sharvani, Kinsler, Rachel E., Vermillion, Meghan S., Gigliotti, Andrew P., Sicard, Veronik, Lloyd, Amy L., Erhardt, Erik B., Gill, Jessica M., Lai, Chen, Guedes, Vivian A., and Chaudry, Irshad H.

Published
2021
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14. Contributors

Author

Alejandro, Ruth E., primary, Alvarez, Gemayaret, additional, Aragaki, Dixie, additional, Asken, Breton M., additional, Azariah, Abana, additional, Bahraini, Nazanin, additional, Bailey, K. Chase, additional, Barcikowski, Jaclyn, additional, Bhatnagar, Saurabha, additional, Bavishi, Sheital, additional, Begley, James J., additional, Benson, Kimberly, additional, Bowles, Amy O., additional, Cabrera, Juan, additional, Cancel, David, additional, Cooper, Douglas B., additional, Correia, Stephen, additional, Crawford, Kelly M., additional, Navarro, Jovany Cruz, additional, Dabaghian, Laurie, additional, Dalal, Kevin, additional, DeDios-Stern, Samantha, additional, Deng, Yi, additional, Desai, Sima A., additional, DiTommaso, Craig, additional, Eapen, Blessen C., additional, Edwards, Jason, additional, Eng, David L., additional, Esterov, Dmitry, additional, Falco, Christopher M., additional, Hernandez, Samantha Fernandez, additional, Fulks, Lauren E., additional, Fusco, Heidi, additional, Galang, Gary Noel, additional, Gilbert-Baffoe, Ekua, additional, Gill, Jessica M., additional, Glazer, David, additional, Goldberg, Gary, additional, González, David Andrés, additional, Greiss, Christine, additional, Haddadin, Zaid, additional, Hazany, Saman, additional, Heath, Kelly M., additional, Hong, Justin Sup, additional, Horvath, Peter, additional, Huang, Jimmy C., additional, Im, Brian, additional, Jasey, Neil, additional, Jones, Dara D., additional, Junn, Cherry, additional, Kennedy, Jan, additional, Kenney, Kimbra, additional, Klyce, Daniel W., additional, Kothari, Sunil, additional, Kunz, Richard D., additional, Lercher, Kirk, additional, Levine, Jaime M., additional, Lin, Katherine, additional, Lin, Matthew, additional, Lindberg, Rani Haley, additional, Ling, Geoffrey S.F., additional, Loughlin, Susan, additional, McGarity, Suzanne, additional, McHenry, Meghan J., additional, McKay, Ondrea, additional, Mernoff, Stephen T., additional, Mohney, Lindsay, additional, Nally, Emma, additional, Nguyen, Benjamin N., additional, O’Connor, Morgan, additional, Otis, Justin B., additional, Pangarkar, Sanjog, additional, Patel, Komal G., additional, Robertson, Claudia, additional, Sabini, Rosanna C., additional, Saint-Preux, Fabienne, additional, Sander, Angelle, additional, Schneider, Andrea L.C., additional, Scholten, Joel Dan, additional, Schultz, Billie, additional, Seel, Ronald T., additional, Segal, Miriam, additional, Sharma, G. Sunny, additional, Soble, Jason R., additional, Spier, Eric T., additional, Stevens, Lillian Flores, additional, Stout, Katharine, additional, Subbarao, Bruno S., additional, Tapia, Rebecca N., additional, Thomas, Alphonsa, additional, Ticknor, Christopher, additional, Valadka, Alex B., additional, Verduzco-Gutierrez, Monica, additional, Verma, Ketan, additional, Vlahos, Nicholas, additional, Watanabe, Thomas, additional, Weppner, Justin Louis, additional, Werner, J. Kent, additional, Whitehair, Victoria C., additional, Wong, Bonny S., additional, Woo, Jean E., additional, Wortzel, Hal S., additional, Yoo, Paul Ki, additional, and Zappaterra, Mauro, additional

Published
2021
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18. Elevated Serum Tau and UCHL-1 Concentrations Within 12 Months of Injury Predict Neurobehavioral Functioning 2 or More Years Following Traumatic Brain Injury: A Longitudinal Study.

Author

Lange, Rael T., Gill, Jessica M., Lippa, Sara M., Hungerford, Lars, Walker, Thomas, Kennedy, Jan, Brickell, Tracey A., and French, Louis M.

Abstract

Objective: Blood-based biomarkers have received considerable attention for their diagnostic and prognostic value in the acute and postacute period following traumatic brain injury (TBI). The purpose of this study was to examine whether blood-based biomarker concentrations within the first 12 months of TBI can predict neurobehavioral outcome in the chronic phase of the recovery trajectory. Setting: Inpatient and outpatient wards from 3 military medical treatment facilities. Participants: A total of 161 service members and veterans classified into 3 groups: (a) uncomplicated mild TBI (MTBI; n = 37), (b) complicated mild, moderate, severe, penetrating TBI combined (STBI; n = 46), and (c) controls (CTRL; n = 78). Design: Prospective longitudinal. Main Measures: Participants completed 6 scales from the Traumatic Brain Injury Quality of Life (ie, Anger, Anxiety, Depression, Fatigue, Headaches, and Cognitive Concerns) within 12 months (baseline) and at 2 or more years (follow-up) post-injury. Serum concentrations of tau, neurofilament light, glial fibrillary acidic protein, and UCHL-1 at baseline were measured using SIMOA. Results: Baseline tau was associated with worse anger, anxiety, and depression in the STBI group at follow-up (R 2 = 0.101-0.127), and worse anxiety in the MTBI group (R 2 = 0.210). Baseline ubiquitin carboxyl-terminal hydrolase L1 (UCHL-1) was associated with worse anxiety and depression at follow-up in both the MTBI and STBI groups (R 2Δ = 0.143-0.207), and worse cognitive concerns in the MTBI group (R 2Δ = 0.223). Conclusions: A blood-based panel including these biomarkers could be a useful tool for identifying individuals at risk of poor outcome following TBI. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Plasma phosphorylated tau181 as a biomarker of mild traumatic brain injury: findings from THINC and NCAA-DoD CARE Consortium prospective cohorts

Author

Devoto, Christina, primary, Vorn, Rany, additional, Mithani, Sara, additional, Meier, Timothy B., additional, Lai, Chen, additional, Broglio, Steven P., additional, McAllister, Thomas, additional, Giza, Christopher C., additional, Huber, Daniel, additional, Harezlak, Jaroslaw, additional, Cameron, Kenneth L., additional, McGinty, Gerald, additional, Jackson, Jonathan, additional, Guskiewicz, Kevin, additional, Mihalik, Jason P., additional, Brooks, Alison, additional, Duma, Stefan, additional, Rowson, Steven, additional, Nelson, Lindsay D., additional, Pasquina, Paul, additional, Turtzo, Christine, additional, Latour, Lawrence, additional, McCrea, Michael A., additional, and Gill, Jessica M., additional

Published
2023
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23. Longitudinal Associations Between Blood Biomarkers and White Matter MRI in Sport-Related Concussion

Author

Wu, Yu-Chien, primary, Wen, Qiuting, additional, Thukral, Rhea, additional, Yang, Ho-Ching, additional, Gill, Jessica M., additional, Gao, Sujuan, additional, Lane, Kathleen A., additional, Meier, Timothy B., additional, Riggen, Larry D., additional, Harezlak, Jaroslaw, additional, Giza, Christopher C., additional, Goldman, Joshua, additional, Guskiewicz, Kevin M., additional, Mihalik, Jason P., additional, LaConte, Stephen M., additional, Duma, Stefan M., additional, Broglio, Steven P., additional, Saykin, Andrew J., additional, McAllister, Thomas Walker, additional, and McCrea, Michael A., additional

Published
2023
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28. Computer-based cognitive rehabilitation interventions for traumatic brain injury: a critical review of the literature

Author

Fetta, Joseph, Starkweather, Angela, and Gill, Jessica M.

Subjects
Technology application, Care and treatment, Complications and side effects, Usage, Methods, Cognitive disorders -- Care and treatment, Rehabilitation -- Methods -- Technology application, Healthcare industry software -- Usage, Brain injuries -- Complications and side effects -- Care and treatment
Abstract

Background: Computer-based interventions have been developed to improve cognitive performance after mild traumatic brain injury; however, a thorough evaluation of this body of research has not been addressed in the [...]

Published
2017
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30. Are EPB41 and alpha-synuclein diagnostic biomarkers of sport-related concussion? Findings from the NCAA and Department of Defense CARE Consortium

Author

Vorn, Rany, primary, Devoto, Christina, additional, Meier, Timothy B., additional, Lai, Chen, additional, Yun, Sijung, additional, Broglio, Steven P., additional, Mithani, Sara, additional, McAllister, Thomas W., additional, Giza, Christopher C., additional, Kim, Hyung-Suk, additional, Huber, Daniel, additional, Harezlak, Jaroslaw, additional, Cameron, Kenneth L., additional, McGinty, Gerald, additional, Jackson, Jonathan, additional, Guskiewicz, Kevin M., additional, Mihalik, Jason P., additional, Brooks, Alison, additional, Duma, Stefan, additional, Rowson, Steven, additional, Nelson, Lindsay D., additional, Pasquina, Paul, additional, McCrea, Michael A., additional, and Gill, Jessica M., additional

Published
2022
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33. Proteomic Profiling of Plasma Biomarkers Associated With Return to Sport Following Concussion: Findings From the NCAA and Department of Defense CARE Consortium

Author

Vorn, Rany, primary, Mithani, Sara, additional, Devoto, Christina, additional, Meier, Timothy B., additional, Lai, Chen, additional, Yun, Sijung, additional, Broglio, Steven P., additional, McAllister, Thomas W., additional, Giza, Christopher C., additional, Kim, Hyung-Suk, additional, Huber, Daniel, additional, Harezlak, Jaroslaw, additional, Cameron, Kenneth L., additional, McGinty, Gerald, additional, Jackson, Jonathan, additional, Guskiewicz, Kevin M., additional, Mihalik, Jason P., additional, Brooks, Alison, additional, Duma, Stefan, additional, Rowson, Steven, additional, Nelson, Lindsay D., additional, Pasquina, Paul, additional, McCrea, Michael A., additional, and Gill, Jessica M., additional

Published
2022
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38. ErbB Signaling Pathway Genes Are Differentially Expressed in Monozygotic Twins Discordant for Sports-Related Concussion

Author

Stahl, Tyler J., primary, Palli, Rohith, additional, Gill, Jessica M., additional, Saionz, Elizabeth L., additional, Bogner-Flatz, Viktoria, additional, Cheetham-West, Arokoruba, additional, Merchant-Borna, Kian, additional, Pham, Dzung L., additional, Strike, Lachlan, additional, Wright, Margaret J., additional, Thompson, Paul, additional, and Bazarian, Jeffrey J., additional

Published
2022
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41. Elevations in Tumor Necrosis Factor Alpha and Interleukin 6 From Neuronal-Derived Extracellular Vesicles in Repeated Low-Level Blast Exposed Personnel

Author

Edwards, Katie A., primary, Leete, Jacqueline J., additional, Smith, Ethan G., additional, Quick, Alycia, additional, Modica, Claire M., additional, Wassermann, Eric M., additional, Polejaeva, Elena, additional, Dell, Kristine C., additional, LoPresti, Matthew, additional, Walker, Peter, additional, O'Brien, Meghan, additional, Lai, Chen, additional, Qu, Bao-Xi, additional, Devoto, Christina, additional, Carr, Walter, additional, Stone, James R., additional, Ahlers, Stephen T., additional, and Gill, Jessica M., additional

Published
2022
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42. Feasibility and preliminary efficacy for morning bright light therapy to improve sleep and plasma biomarkers in US Veterans with TBI. A prospective, open-label, single-arm trial

Author

Elliott, Jonathan E., primary, McBride, Alisha A., additional, Balba, Nadir M., additional, Thomas, Stanley V., additional, Pattinson, Cassandra L., additional, Morasco, Benjamin J., additional, Wilkerson, Andrea, additional, Gill, Jessica M., additional, and Lim, Miranda M., additional

Published
2022
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43. Remote blast-related mild traumatic brain injury is associated with differential expression of exosomal microRNAs identified in neurodegenerative and immunological processes

Author

Devoto, Christina, primary, Guedes, Vivian A., additional, Lai, Chen, additional, Leete, Jacqueline J., additional, Mithani, Sara, additional, Edwards, Katie, additional, Vorn, Rany, additional, Qu, Bao-Xi, additional, Wilde, Elisabeth A., additional, Walker, William C., additional, Diaz-Arrastia, Ramon, additional, Werner, J Kent, additional, Kenney, Kimbra, additional, and Gill, Jessica M., additional

Published
2022
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44. A Pilot Study of Whole-Blood Transcriptomic Analysis to Identify Genes Associated with Repetitive Low-Level Blast Exposure in Career Breachers

Author

Vorn, Rany, primary, Edwards, Katie A., additional, Hentig, James, additional, Yun, Sijung, additional, Kim, Hyung-Suk, additional, Lai, Chen, additional, Devoto, Christina, additional, Yarnell, Angela M., additional, Polejaeva, Elena, additional, Dell, Kristine C., additional, LoPresti, Matthew L., additional, Walker, Peter, additional, Carr, Walter, additional, Stone, James R., additional, Ahlers, Stephen T., additional, and Gill, Jessica M., additional

Published
2022
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45. Proteomic Profiling of Plasma Biomarkers Associated With Return to Sport Following Concussion: Findings From the NCAA and Department of Defense CARE Consortium

Author

Lai, Chen, Broglio, Steven P., Brooks, Alison, McCrea, Michael A., McGinty, Gerald, Mithani, Sara, Yun, Sijung, Meier, Timothy B., McAllister, Thomas W., Gill, Jessica M., Pasquina, Paul, Duma, Stefan, Nelson, Lindsay D., Guskiewicz, Kevin M., Jackson, Jonathan, Devoto, Christina, Mihalik, Jason P., Vorn, Rany, Kim, Hyung-Suk, CARE Consortium Investigators, Harezlak, Jaroslaw, Giza, Christopher C., Huber, Daniel, Cameron, Kenneth L., and Rowson, Steven

Abstract

ObjectiveTo investigate the plasma proteomic profiling in identifying biomarkers related to return to sport (RTS) following a sport-related concussion (SRC).MethodsThis multicenter, prospective, case-control study was part of a larger cohort study conducted by the NCAA-DoD Concussion Assessment, Research, and Education (CARE) Consortium, athletes (n = 140) with blood collected within 48 h of injury and reported day to asymptomatic were included in this study, divided into two groups: (1) recovery

Published
2022
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47. Poor Sleep Quality is Linked to Elevated Extracellular Vesicle-Associated Inflammatory Cytokines in Warfighters With Chronic Mild Traumatic Brain Injuries

Author

Gottshall, Jackie L., primary, Guedes, Vivian A., additional, Pucci, Josephine U., additional, Brooks, Daniel, additional, Watson, Nora, additional, Sheth, Phorum, additional, Gabriel, Ainslee, additional, Mithani, Sara, additional, Leete, Jacqueline J., additional, Lai, Chen, additional, Qu, Bao-Xi, additional, Devoto, Christina, additional, Gill, Jessica M., additional, Kenney, Kimbra, additional, and Werner, J. Kent, additional

Published
2022
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