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1. Precursor Epithelial Subtypes of Adenocarcinoma Arising from Intraductal Papillary Mucinous Neoplasms (A-IPMN): Clinicopathological Features, Recurrence and Response to Adjuvant Chemotherapy

Author

Lucocq, James, Haugk, Beate, Parkinson, Daniel, Darne, Antony, Joseph, Nejo, Hawkyard, Jake, White, Steve, Mownah, Omar, Menon, Krishna, Furukawa, Takaki, Inoue, Yosuke, Hirose, Yuki, Sasahira, Naoki, Mittal, Anubhav, Samra, Jas, Sheen, Amy, Feretis, Michael, Balakrishnan, Anita, Ceresa, Carlo, Davidson, Brian, Pande, Rupaly, Dasari, Bobby V. M., Tanno, Lulu, Karavias, Dimitrios, Helliwell, Jack, Young, Alistair, Nunes, Quentin, Urbonas, Tomas, Silva, Michael, Gordon-Weeks, Alex, Barrie, Jenifer, Gomez, Dhanny, van Laarhoven, Stijn, Nawara, Hossam, Doyle, Joseph, Bhogal, Ricky, Harrison, Ewen, Roalso, Marcus, Ciprani, Deborah, Aroori, Somaiah, Ratnayake, Bathiya, Koea, Jonathan, Capurso, Gabriele, Bellotti, Ruben, Stättner, Stefan, Alsaoudi, Tareq, Bhardwaj, Neil, Jeffery, Fraser, Connor, Saxon, Cameron, Andrew, Jamieson, Nigel, Roberts, Keith, Soreide, Kjetil, Gill, Anthony J., and Pandanaboyana, Sanjay

Published
2024
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3. The genomic and evolutionary landscapes of anaplastic thyroid carcinoma

Author

Zeng, Peter YF, Prokopec, Stephenie D, Lai, Stephen Y, Pinto, Nicole, Chan-Seng-Yue, Michelle A, Clifton-Bligh, Roderick, Williams, Michelle D, Howlett, Christopher J, Plantinga, Paul, Cecchini, Matthew J, Lam, Alfred K, Siddiqui, Iram, Wang, Jianxin, Sun, Ren X, Watson, John D, Korah, Reju, Carling, Tobias, Agrawal, Nishant, Cipriani, Nicole, Ball, Douglas, Nelkin, Barry, Rooper, Lisa M, Bishop, Justin A, Garnis, Cathie, Berean, Ken, Nicolson, Norman G, Weinberger, Paul, Henderson, Ying C, Lalansingh, Christopher M, Tian, Mao, Yamaguchi, Takafumi N, Livingstone, Julie, Salcedo, Adriana, Patel, Krupal, Vizeacoumar, Frederick, Datti, Alessandro, Xi, Liu, Nikiforov, Yuri E, Smallridge, Robert, Copland, John A, Marlow, Laura A, Hyrcza, Martin D, Delbridge, Leigh, Sidhu, Stan, Sywak, Mark, Robinson, Bruce, Fung, Kevin, Ghasemi, Farhad, Kwan, Keith, MacNeil, S Danielle, Mendez, Adrian, Palma, David A, Khan, Mohammed I, Shaikh, Mushfiq, Ruicci, Kara M, Wehrli, Bret, Winquist, Eric, Yoo, John, Mymryk, Joe S, Rocco, James W, Wheeler, David, Scherer, Steve, Giordano, Thomas J, Barrett, John W, Faquin, William C, Gill, Anthony J, Clayman, Gary, Boutros, Paul C, and Nichols, Anthony C

Subjects
Biological Sciences, Genetics, Human Genome, Cancer, Rare Diseases, Aetiology, 2.1 Biological and endogenous factors, Humans, Thyroid Carcinoma, Anaplastic, Thyroid Neoplasms, Mutation, Adenocarcinoma, Genomics, CP: Cancer, CP: Genomics, anaplastic thyroid cancer, cancer progression, genomics, tumour evolution, tumour heterogeneity, Biochemistry and Cell Biology, Medical Physiology, Biological sciences
Abstract

Anaplastic thyroid carcinoma is arguably the most lethal human malignancy. It often co-occurs with differentiated thyroid cancers, yet the molecular origins of its aggressivity are unknown. We sequenced tumor DNA from 329 regions of thyroid cancer, including 213 from patients with primary anaplastic thyroid carcinomas. We also whole genome sequenced 9 patients using multi-region sequencing of both differentiated and anaplastic thyroid cancer components. Using these data, we demonstrate thatanaplastic thyroid carcinomas have a higher burden of mutations than other thyroid cancers, with distinct mutational signatures and molecular subtypes. Further, different cancer driver genes are mutated in anaplastic and differentiated thyroid carcinomas, even those arising in a single patient. Finally, we unambiguously demonstrate that anaplastic thyroid carcinomas share a genomic origin with co-occurring differentiated carcinomas and emerge from a common malignant field through acquisition of characteristic clonal driver mutations.

Published
2024

4. MET-receptor targeted fluorescent imaging and spectroscopy to detect multifocal papillary thyroid cancer

Author

Metman, Madelon J. H., Jonker, Pascal K. C., Sondorp, Luc H. J., van Hemel, Bettien M., Sywak, Mark S., Gill, Anthony J., Jansen, Liesbeth, van Diest, Paul J., van Ginhoven, Tessa M., Löwik, Clemens W. G. M., Nguyen, Anh H., Robinson, Dominic J., van Dam, Gooitzen M., Links, Thera P., Coppes, Rob P., Fehrmann, Rudolf S. N., and Kruijff, Schelto

Published
2024
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5. ASO Visual Abstract: Precursor Epithelial Subtypes of Adenocarcinoma Arising from Intraductal Papillary Mucinous Neoplasms (A-IPMN)—Clinicopathological Features, Recurrence and Response to Adjuvant Chemotherapy

Author

Lucocq, James, Haugk, Beate, Parkinson, Daniel, Darne, Antony, Joseph, Nejo, Hawkyard, Jake, White, Steve, Mownah, Omar, Menon, Krishna, Furukawa, Takaki, Inoue, Yosuke, Hirose, Yuki, Sasahira, Naoki, Mittal, Anubhav, Samra, Jas, Sheen, Amy, Feretis, Michael, Balakrishnan, Anita, Ceresa, Carlo, Davidson, Brian, Pande, Rupaly, Dasari, Bobby V. M., Tanno, Lulu, Karavias, Dimitrios, Helliwell, Jack, Young, Alistair, Nunes, Quentin, Urbonas, Tomas, Silva, Michael, Gordon-Weeks, Alex, Barrie, Jenifer, Gomez, Dhanny, van Laarhoven, Stijn, Nawara, Hossam, Doyle, Joseph, Bhogal, Ricky, Harrison, Ewen, Roalso, Marcus, Ciprani, Deborah, Aroori, Somaiah, Ratnayake, Bathiya, Koea, Jonathan, Capurso, Gabriele, Bellotti, Ruben, Stättner, Stefan, Alsaoudi, Tareq, Bhardwaj, Neil, Jeffery, Fraser, Connor, Saxon, Cameron, Andrew, Jamieson, Nigel, Roberts, Keith, Soreide, Kjetil, Gill, Anthony J., and Pandanaboyana, Sanjay

Published
2024
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7. Gene expression profiling of mucinous ovarian tumors and comparison with upper and lower gastrointestinal tumors identifies markers associated with adverse outcomes.

Author

Meagher, Nicola S, Gorringe, Kylie L, Wakefield, Matthew, Bolithon, Adelyn, Pang, Chi Nam Ignatius, Chiu, Derek S, Anglesio, Michael S, Mallitt, Kylie-Ann, Doherty, Jennifer A, Harris, Holly R, Schildkraut, Joellen M, Berchuck, Andrew, Cushing-Haugen, Kara L, Chezar, Ksenia, Chou, Angela, Tan, Adeline, Alsop, Jennifer, Barlow, Ellen, Beckmann, Matthias W, Boros, Jessica, Bowtell, David DL, Group, for the AOCS, Brand, Alison H, Brenton, James D, Campbell, Ian, Cheasley, Dane, Cohen, Joshua, Cybulski, Cezary, Elishaev, Esther, Erber, Ramona, Farrell, Rhonda, Fischer, Anna, Fu, Zhuxuan, Gilks, Blake, Gill, Anthony J, Initiative, for the Australian Pancreatic Genome, Gourley, Charlie, Grube, Marcel, Harnett, Paul R, Hartmann, Arndt, Hettiaratchi, Anusha, Høgdall, Claus K, Huzarski, Tomasz, Jakubowska, Anna, Jimenez-Linan, Mercedes, Kennedy, Catherine J, Kim, Byoung-Gie, Kim, Jae-Weon, Kim, Jae-Hoon, Klett, Kayla, Koziak, Jennifer M, Lai, Tiffany, Laslavic, Angela, Lester, Jenny, Leung, Yee, Li, Na, Liauw, Winston, Lim, Belle WX, Linder, Anna, Lubiński, Jan, Mahale, Sakshi, Mateoiu, Constantina, McInerny, Simone, Menkiszak, Janusz, Minoo, Parham, Mittelstadt, Suzana, Morris, David, Orsulic, Sandra, Park, Sang-Yoon, Pearce, Celeste Leigh, Pearson, John V, Pike, Malcolm C, Quinn, Carmel M, Mohan, Ganendra Raj, Rao, Jianyu, Riggan, Marjorie J, Ruebner, Matthias, Salfinger, Stuart, Scott, Clare L, Shah, Mitul, Steed, Helen, Stewart, Colin JR, Subramanian, Deepak, Sung, Soseul, Tang, Katrina, Timpson, Paul, Ward, Robyn L, Wiedenhoefer, Rebekka, Thorne, Heather, Investigators, for the kConFab, Cohen, Paul A, Crowe, Philip, Fasching, Peter A, Gronwald, Jacek, Hawkins, Nicholas J, Høgdall, Estrid, Huntsman, David G, James, Paul A, Karlan, Beth Y, and Kelemen, Linda E

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Ovarian Cancer, Rare Diseases, Cancer, Digestive Diseases, Genetics, 4.1 Discovery and preclinical testing of markers and technologies, Detection, screening and diagnosis, Female, Humans, Neoplasm Staging, Ovarian Neoplasms, Carcinoma, Ovarian Epithelial, Adenocarcinoma, Mucinous, Prognosis, Gastrointestinal Neoplasms, AOCS Group, Australian Pancreatic Genome Initiative, kConFab Investigators, Oncology & Carcinogenesis, Clinical sciences, Oncology and carcinogenesis
Abstract

PurposeAdvanced-stage mucinous ovarian carcinoma (MOC) has poor chemotherapy response and prognosis and lacks biomarkers to aid stage I adjuvant treatment. Differentiating primary MOC from gastrointestinal (GI) metastases to the ovary is also challenging due to phenotypic similarities. Clinicopathologic and gene-expression data were analyzed to identify prognostic and diagnostic features.Experimental designDiscovery analyses selected 19 genes with prognostic/diagnostic potential. Validation was performed through the Ovarian Tumor Tissue Analysis consortium and GI cancer biobanks comprising 604 patients with MOC (n = 333), mucinous borderline ovarian tumors (MBOT, n = 151), and upper GI (n = 65) and lower GI tumors (n = 55).ResultsInfiltrative pattern of invasion was associated with decreased overall survival (OS) within 2 years from diagnosis, compared with expansile pattern in stage I MOC [hazard ratio (HR), 2.77; 95% confidence interval (CI), 1.04-7.41, P = 0.042]. Increased expression of THBS2 and TAGLN was associated with shorter OS in MOC patients (HR, 1.25; 95% CI, 1.04-1.51, P = 0.016) and (HR, 1.21; 95% CI, 1.01-1.45, P = 0.043), respectively. ERBB2 (HER2) amplification or high mRNA expression was evident in 64 of 243 (26%) of MOCs, but only 8 of 243 (3%) were also infiltrative (4/39, 10%) or stage III/IV (4/31, 13%).ConclusionsAn infiltrative growth pattern infers poor prognosis within 2 years from diagnosis and may help select stage I patients for adjuvant therapy. High expression of THBS2 and TAGLN in MOC confers an adverse prognosis and is upregulated in the infiltrative subtype, which warrants further investigation. Anti-HER2 therapy should be investigated in a subset of patients. MOC samples clustered with upper GI, yet markers to differentiate these entities remain elusive, suggesting similar underlying biology and shared treatment strategies.

Published
2022

8. ALKTERNATE: A Pilot Study Alternating Lorlatinib With Crizotinib in ALK-Positive NSCLC With Prior ALK Inhibitor Resistance

Author

Itchins, Malinda, Liang, Shirley, Brown, Chris, Barnes, Tristan, Marx, Gavin, Chin, Venessa, Kao, Steven, Yip, Po Yee, Mersiades, Antony J., Nagrial, Adnan, Bray, Victoria, Peters, Geoffrey, Parakh, Sagun, Garg, Kavita, Li, Bob T., McKay, Matthew, O'Byrne, Kenneth, John, Thomas, Gill, Anthony J., Molloy, Mark P., Solomon, Benjamin J., and Pavlakis, Nick

Published
2024
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9. A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer

Author

Chitty, Jessica L., Yam, Michelle, Perryman, Lara, Parker, Amelia L., Skhinas, Joanna N., Setargew, Yordanos F. I., Mok, Ellie T. Y., Tran, Emmi, Grant, Rhiannon D., Latham, Sharissa L., Pereira, Brooke A., Ritchie, Shona C., Murphy, Kendelle J., Trpceski, Michael, Findlay, Alison D., Melenec, Pauline, Filipe, Elysse C., Nadalini, Audrey, Velayuthar, Sipiththa, Major, Gretel, Wyllie, Kaitlin, Papanicolaou, Michael, Ratnaseelan, Shivanjali, Phillips, Phoebe A., Sharbeen, George, Youkhana, Janet, Russo, Alice, Blackwell, Antonia, Hastings, Jordan F., Lucas, Morghan C., Chambers, Cecilia R., Reed, Daniel A., Stoehr, Janett, Vennin, Claire, Pidsley, Ruth, Zaratzian, Anaiis, Da Silva, Andrew M., Tayao, Michael, Charlton, Brett, Herrmann, David, Nobis, Max, Clark, Susan J., Biankin, Andrew V., Johns, Amber L., Croucher, David R., Nagrial, Adnan, Gill, Anthony J., Grimmond, Sean M., Pajic, Marina, Timpson, Paul, Jarolimek, Wolfgang, and Cox, Thomas R.

Published
2023
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10. Fibroblast Activation Protein Is Overexpressed on Both Stromal and Epithelial Cells Before Pancreatic Ductal Adenocarcinoma: Implications for Early Diagnosis on 68Ga-FAPI-PET/CT

Author

Cooper, Caroline, Butler, Nick, Yeung, Shinn, Kryza, Thomas, Gulhane, Brook, Latter, Melissa J., Waddell, Nicola, Samra, Jaswinder S., Simpson, Fiona, Pajic, Marina, Thomas, Paul A., O’Rourke, Thomas, Hooper, John D., McGahan, William, Gough, Madeline, Liu, Cheng, Hoyte, Sharon, Gill, Anthony J., and Cavallucci, David

Published
2024
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11. Invasive intraductal oncocytic papillary neoplasms (IOPN) and adenocarcimoma arising from intraductal papillary mucinous neoplasms (A-IPMN) of the pancreas: comparative analysis of clinicopathological features, patterns of recurrence and survival: a multicentre study

Author

Lucocq, James, Haugk, Beate, Joseph, Nejo, Hawkyard, Jake, White, Steve, Mownah, Omar, Menon, Krishna, Furukawa, Takaki, Inoue, Yosuke, Hirose, Yuki, Sasahira, Naoki, Mittal, Anubhav, Samra, Jas, Sheen, Amy, Feretis, Michael, Balakrishnan, Anita, Ceresa, Carlo, Davidson, Brian, Pande, Rupaly, Dasari, Bobby V.M., Tanno, Lulu, Karavias, Dimitrios, Helliwell, Jack, Young, Alistair, Nunes, Quentin, Urbonas, Tomas, Silva, Michael, Gordon-Weeks, Alex, Barrie, Jenifer, Gomez, Dhanny, van Laarhoven, Stijn, Nawara, Hossam, Doyle, Joseph, Bhogal, Ricky, Harrison, Ewen, Roalso, Marcus, Zaharia, Claudia, Ciprani, Debora, Aroori, Somaiah, Ratnayake, Bathiya, Koea, Jonathan, Capurso, Gabriele, Bellotti, Ruben, Stättner, Stefan, Alsaoudi, Tareq, Bhardwaj, Neil, Jeffery, Fraser, Connor, Saxon, Cameron, Andrew, Jamieson, Nigel, Roberts, Keith, Soreide, Kjetil, Gill, Anthony J., and Pandanaboyana, Sanjay

Published
2024
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12. Long-term Outcomes following Resection of Adenocarcinoma Arising from Intraductal Papillary Mucinous Neoplasm (A-IPMN) versus Pancreatic Ductal Adenocarcinoma (PDAC): A Propensity-score Matched Analysis

Author

Lucocq, James, Halle-Smith, James, Haugk, Beate, Joseph, Nejo, Hawkyard, Jake, Lye, Jonathan, Parkinson, Daniel, White, Steve, Mownah, Omar, Zen, Yoh, Menon, Krishna, Furukawa, Takaki, Inoue, Yosuke, Hirose, Yuki, Sasahira, Naoki, Mittal, Anubhav, Samra, Jas, Sheen, Amy, Feretis, Michael, Balakrishnan, Anita, Ceresa, Carlo, Davidson, Brian, Pande, Rupaly, Dasari, Bobby V.M., Tanno, Lulu, Karavias, Dimitrios, Helliwell, Jack, Young, Alistair, Marks, Kate, Nunes, Quentin, Urbonas, Tomas, Silva, Michael, Gordon-Weeks, Alex, Barrie, Jenifer, Gomez, Dhanny, van Laarhoven, Stijn, Nawara, Hossam, Doyle, Joseph, Bhogal, Ricky, Harrison, Ewen, Roalso, Marcus, Ciprani, Debora, Aroori, Somaiah, Ratnayake, Bathiya, Koea, Jonathan, Capurso, Gabriele, Bellotti, Ruben, Stättner, Stefan, Alsaoudi, Tareq, Bhardwaj, Neil, Rajesh, Srujan, Jeffery, Fraser, Connor, Saxon, Cameron, Andrew, Jamieson, Nigel, Soreide, Kjetil, Gill, Anthony J., Roberts, Keith, and Pandanaboyana, Sanjay

Published
2024
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14. Author Correction: Single-nuclei and bulk-tissue gene-expression analysis of pheochromocytoma and paraganglioma links disease subtypes with tumor microenvironment

Author

Zethoven, Magnus, Martelotto, Luciano, Pattison, Andrew, Bowen, Blake, Balachander, Shiva, Flynn, Aidan, Rossello, Fernando J., Hogg, Annette, Miller, Julie A., Frysak, Zdenek, Grimmond, Sean, Fishbein, Lauren, Tischler, Arthur S., Gill, Anthony J., Hicks, Rodney J., Dahia, Patricia L. M., Clifton-Bligh, Roderick, Pacak, Karel, and Tothill, Richard W.

Published
2023
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22. A Detailed Histologic and Molecular Assessment of the Diffuse Sclerosing Variant of Papillary Thyroid Carcinoma

Author

Chou, Angela, Qiu, Min Ru, Crayton, Henry, Wang, Bin, Ahadi, Mahsa S., Turchini, John, Clarkson, Adele, Sioson, Loretta, Sheen, Amy, Singh, Nisha, Clifton-Bligh, Roderick J., Robinson, Bruce G., Gild, Matti L., Tsang, Venessa, Leong, David, Sidhu, Stanley B., Sywak, Mark, Delbridge, Leigh, Aniss, Ahmad, Wright, Dale, Graf, Nicole, Kumar, Amit, Rathi, Vivek, Benitez-Aguirre, Paul, Glover, Anthony R., and Gill, Anthony J.

Published
2023
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25. Intraoperative MET-receptor targeted fluorescent imaging and spectroscopy for lymph node detection in papillary thyroid cancer: novel diagnostic tools for more selective central lymph node compartment dissection

Author

Jonker, Pascal K. C., Metman, Madelon J. H., Sondorp, Luc H. J., Sywak, Mark S., Gill, Anthony J., Jansen, Liesbeth, Links, Thera P., van Diest, Paul J., van Ginhoven, Tessa M., Löwik, Clemens W. G. M., Nguyen, Anh H., Coppes, Robert P., Robinson, Dominic J., van Dam, Gooitzen M., van Hemel, Bettien M., Fehrmann, Rudolf S. N., and Kruijff, Schelto

Published
2022
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28. Expanding the clinicopathological spectrum of succinate dehydrogenase-deficient renal cell carcinoma with a focus on variant morphologies: a study of 62 new tumors in 59 patients

Author

Fuchs, Talia L., Maclean, Fiona, Turchini, John, Vargas, A. Cristina, Bhattarai, Selina, Agaimy, Abbas, Hartmann, Arndt, Kao, Chia-Sui, Ellis, Carla, Bonert, Michael, Leroy, Xavier, Kunju, Lakshmi P., Schwartz, Lauren, Matsika, Admire, Williamson, Sean R., Rao, Priya, Divatia, Mukul, Guarch, Rosa, Algaba, Ferran, Balancin, Marcelo L., Zhou, Ming, Samaratunga, Hemamali, da Cunha, Isabela Werneck, Brimo, Fadi, Ryan, Andrew, Clouston, David, Aron, Manju, O’Donnell, Marie, Chan, Emily, Hirsch, Michelle S., Moch, Holger, Pang, Chun-Yin, Wah, Cheuk, Yin, Weihua, Perry-Keene, Joanna, Yilmaz, Asli, Chou, Angela, Clarkson, Adele, van der Westhuizen, Gerhard, Morrison, Ella, Zwi, Jonathan, Hes, Ondrej, Trpkov, Kiril, and Gill, Anthony J.

Published
2022
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35. Eosinophilic vacuolated tumor (EVT) of kidney demonstrates sporadic TSC/MTOR mutations: next-generation sequencing multi-institutional study of 19 cases

Author

Farcaş, Mihaela, Gatalica, Zoran, Trpkov, Kiril, Swensen, Jeffrey, Zhou, Ming, Alaghehbandan, Reza, Williamson, Sean R., Magi-Galluzzi, Cristina, Gill, Anthony J., Tretiakova, Maria, Lopez, Jose I., Montiel, Delia Perez, Sperga, Maris, Comperat, Eva, Brimo, Fadi, Yilmaz, Asli, Siadat, Farshid, Sangoi, Ankur, Gao, Yuan, Ptákova, Nikola, Kuthi, Levente, Pivovarcikova, Kristyna, Rogala, Joanna, Agaimy, Abbas, Hartmann, Arndt, Fraune, Cristoph, Rychly, Boris, Hurnik, Pavel, Durcansky, Dušan, Bonert, Michael, Gakis, Georgios, Michal, Michal, Hora, Milan, and Hes, Ondrej

Published
2022
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39. Single-nuclei and bulk-tissue gene-expression analysis of pheochromocytoma and paraganglioma links disease subtypes with tumor microenvironment

Author

Zethoven, Magnus, Martelotto, Luciano, Pattison, Andrew, Bowen, Blake, Balachander, Shiva, Flynn, Aidan, Rossello, Fernando J., Hogg, Annette, Miller, Julie A., Frysak, Zdenek, Grimmond, Sean, Fishbein, Lauren, Tischler, Arthur S., Gill, Anthony J., Hicks, Rodney J., Dahia, Patricia L. M., Clifton-Bligh, Roderick, Pacak, Karel, and Tothill, Richard W.

Published
2022
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41. BRAF mutation testing for patients diagnosed with stage III or stage IV melanoma: practical guidance for the Australian setting

Author

Scolyer, Richard A., Atkinson, Victoria, Gyorki, David E., Lambie, Duncan, O'Toole, Sandra, Saw, Robyn P.M., Amanuel, Benhur, Angel, Christopher M., Button-Sloan, Alison E., Carlino, Matteo S., Ch'ng, Sydney, Colebatch, Andrew J., Daneshvar, Dariush, Pires da Silva, Inês, Dawson, Tamara, Ferguson, Peter M., Foster-Smith, Erwin, Fox, Stephen B., Gill, Anthony J., Gupta, Ruta, Henderson, Michael A., Hong, Angela M., Howle, Julie R., Jackett, Louise A., James, Craig, Lee, C. Soon, Lochhead, Alistair, Loh, Daphne, McArthur, Grant A., McLean, Catriona A., Menzies, Alexander M., Nieweg, Omgo E., O'Brien, Blake H., Pennington, Thomas E., Potter, Alison J., Prakash, Saurabh, Rawson, Robert V., Read, Rebecca L., Rtshiladze, Michael A., Shannon, Kerwin F., Smithers, B. Mark, Spillane, Andrew J., Stretch, Jonathan R., Thompson, John F., Tucker, Paul, Varey, Alexander H.R., Vilain, Ricardo E., Wood, Benjamin A., and Long, Georgina V.

Published
2022
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43. Esophageal lymphocytosis: exploring the knowns and unknowns of this pattern of esophageal injury.

Author

Coady, Laoise C., Sheahan, Kieran, Brown, Ian S., Carneiro, Fátima, Gill, Anthony J., Kumarasinghe, Priyanthi, Kushima, Ryoji, Lauwers, Gregory Y., Pai, Rish K., Shepherd, Neil A., Slavik, Tomas, Srivastava, Amitabh, and Langner, Cord

Subjects
GASTROESOPHAGEAL reflux, DRUG side effects, LITERATURE reviews, CANDIDIASIS, BOLUS (Digestion), EOSINOPHILIC esophagitis
Abstract

Introduction: Lymphocyte-rich inflammation of the esophageal mucosa has gained increased awareness among pathologists and clinicians recently. Patients usually present with symptoms of esophageal dysfunction, including dysphagia and food bolus impaction. Endoscopy may show changes similar to eosinophilic esophagitis but may also be entirely normal ('microscopic esophagitis'). Three morphological subtypes or variant forms have been described which include lymphocytic, lichenoid and lymphocyte-predominant esophagitis. These need to be discriminated against other distinct causes of esophageal lymphocytosis, such as gastro-esophageal reflux disease and Candida infection. Areas covered: This review provides an overview of diagnostic criteria and clinical associations of the disorder and presents an algorithmic approach to diagnosis. A comprehensive literature review was conducted using PubMed, Medline and Google Scholar databases to identify articles related to lymphocyte-rich esophageal inflammation, published up to March 2024. Expert opinion: Lymphocyte-rich inflammation needs to be included in the differential diagnosis and clinical work-up of patients with esophageal dysfunction. There is currently considerable morphological overlap among published subtypes or variant forms. Follow-up studies of affected individuals are needed to formalize diagnostic parameters and identify the clinical course of disease in order to optimize treatment modalities. [ABSTRACT FROM AUTHOR]

Published
2024
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44. Artificial Intelligence-based Segmentation of Residual Pancreatic Cancer in Resection Specimens Following Neoadjuvant Treatment (ISGPP-2): International Improvement and Validation Study.

Author

Janssen, Boris V., Oteman, Bart, Ali, Mahsoem, Valkema, Pieter A., Adsay, Volkan, Basturk, Olca, Chatterjee, Deyali, Chou, Angela, Crobach, Stijn, Doukas, Michael, Drillenburg, Paul, Esposito, Irene, Gill, Anthony J., Seung-Mo Hong, Jansen, Casper, Kliffen, Mike, Mittal, Anubhav, Samra, Jas, van Velthuysen, Marie-Louise F., and Yavas, Aslihan

Published
2024
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46. Multimodality Treatment Improves Locoregional Control, Progression-Free and Overall Survival in Patients with Anaplastic Thyroid Cancer: A Retrospective Cohort Study Comparing Oncological Outcomes and Morbidity between Multimodality Treatment and Limited Treatment

Author

Jonker, Pascal K. C., Turchini, John, Kruijff, Schelto, Lin, Jia Feng, Gill, Anthony J., Eade, Thomas, Aniss, Ahmad, Clifton-Bligh, Roderick, Learoyd, Diana, Robinson, Bruce, Tsang, Venessa, Glover, Anthony, Sidhu, Stanley, and Sywak, Mark

Published
2021
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