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Leptin is a homeostatic regulatory element that signals the presence of adipocyte energy stores, reduces food intake, and increases energy expenditure. Similarly, serotonin (5-HT), a signaling molecule found in both the central and peripheral nervous systems, also controls food intake. Using neuronal tract tracing, pharmacologic and optogenetic approaches, and in vivo microdialysis, combined with behavioral end points, we tested the hypothesis that leptin controls food intake not only by activating hypothalamic leptin receptors (LepRs) but also through activation of LepRs expressed by serotonergic raphe neurons that send projections to the arcuate (ARC). We showed that microinjection of leptin directly into the dorsal raphe nucleus (DRN) reduced food intake in rats. This effect was mediated by LepR-expressing neurons in the DRN, because selective optogenetic activation of these neurons at either their DRN cell bodies or their ARC terminals reduced food intake. Anatomically, we identified a unique population of serotonergic raphe neurons expressing LepRs that send projections to the ARC. Finally, by using in vivo microdialysis, we showed that leptin administration to the DRN increased 5-HT efflux into the ARC, and specific antagonism of the 5-HT2C receptors in the ARC diminished the leptin anorectic effect. Overall, this study identified a novel circuit for leptin-mediated control of food intake through a DRN-ARC pathway, identifying a new level of interaction between leptin and serotonin to control food intake. Characterization of this new pathway creates opportunities for understanding how the brain controls eating behavior and opens alternative routes for the treatment of eating disorders., (© 2024 by the American Diabetes Association.)

This article sets out to establish the naturalistic study of online social communication as a substantive topic in social psychology and to discuss the challenges of developing methods for a formal analysis of the structural and interactional features of message threads on discussion forums. I begin by outlining the essential features of online communication and specifically discussion forum data, and the important ways in which they depart from spoken conversation. I describe the handful of attempts to devise systematic analytic techniques for adapting methods such as conversation and discourse analysis to the study of online discussion. I then present a case study of a thread from the popular UK parenting forum Mumsnet which presents a number of challenges for existing methods, and examine some of the interactive phenomena typical of forums. Finally, I consider ways in which membership categorization analysis and social identity theory can complement one another in the exploration of both group processes and the rhetorical deployment of identities as dynamic phenomena in online discussion., (© 2016 The British Psychological Society.)

This article considers the fate of Asperger's disorder in the light of proposals for the Diagnostic and Statistical Manual of Mental Disorders (5th ed.) to collapse Asperger's disorder along with other pervasive developmental disorders into a general spectrum of autism. It is argued that a powerful lay and scientific culture has evolved around the concept of Asperger's disorder, which has found a particularly compelling voice over the last decade in the online Asperger community, with websites such as Wrong Planet recruiting tens of thousands of members. In order to assess the impact of these proposed changes on the online Asperger community, 19 threads on the topic of Diagnostic and Statistical Manual of Mental Disorders (5th ed.) are analysed according to the arguments that community members put forward in favour of, or in opposition to, the proposals. Many members embrace the notion of the spectrum and have already coined a new identity - 'spectrumite' - to adapt to the diagnostic shift. Others, however, are suspicious of the motives behind the absorption of Asperger's disorder, and potential threats to the provision of services as well as the strong 'aspie' identity that reflects the large literature and the online public sphere around Asperger's disorder. To what extent this culture poses a challenge to the authority of the Diagnostic and Statistical Manual of Mental Disorders is uncertain at present.

This article consists of a qualitative analysis of discussion forums in online mental health communities whose members routinely write about diagnosis. The analysis concerns the function of diagnosis from the perspective of personal identity, with particular focus on the status of official diagnosis, as well as community members' discussions of symptoms and psychiatric syndromes that amount to informal diagnosis or consultation. Self-diagnosis sometimes takes the form of recommended "quizzes" and other online quasi-diagnostic tools. Other-diagnosis, in which a third party is discussed by community members, is also considered. We discuss the implications of such online discourse for Internet users themselves as well the challenges for the health and medical professions.

Changing gender roles and increased sexual and economic freedom have created opportunities for women to give birth relatively late in life. However, stigma and misplaced fears about physical capacity are often reported as sources of anxiety among older, and in vitro fertilisation-induced mothers. In this study, we apply a specially adapted method for analysing news media content to a week's selection of material in the British media following the dissemination of research at an international medical conference. Our findings suggest, despite some positive commentaries, that much negative discourse is circulated by the media about older mothers, from implied claims of selfishness (older mothers as 'delaying' conception) to violations of the 'natural order'. These latter claims reflect the long-standing ambivalence by the media generally towards scientific advancement, but they also reveal continuing resistance towards unorthodox lifestyles.

Objectives: The aim of the present study was to examine the relationship between celebrity worship and body image within the theoretical perspective of intense para-social relationships with celebrities., Design: Correlation and multiple regression analyses were used to examine the relationships between celebrity worship and body image., Method: Three samples, 229 (102 males and 127 females) adolescents, 183 (88 males and 95 females) full-time university undergraduate students, and 289 (126 males and 163 females) adults were administered an amended version of the Celebrity Attitude Scale, the Attention to Body Shape Scale, and the Body Shape Questionnaire-Revised., Results: Significant relationships were found between attitudes toward celebrities and body image only among female adolescents. Multiple regression analyses suggested that Intense-personal celebrity worship accounted for unique variance in scores in body image., Conclusions: Findings suggest that in female adolescents, there is an interaction between Intense-personal celebrity worship and body image between the ages of 14 and 16 years, and some tentative evidence has been found to suggest that this relationship disappears at the onset of adulthood, 17 to 20 years. Results are consistent with those authors who stress the importance of the formation of para-social relationships with media figures, and suggest that para-social relationships with celebrities perceived as having a good body shape may lead to a poor body image in female adolescents.

Media representations of health and illness have come under scrutiny for their ability to mislead and misinform the public about health issues. However, the media also provide a public forum in which talk about health and illness may be circulated in a more positive fashion. This article consists of a narrative analysis of an episode of the BBC talk show Kilroy, in which the topic of obesity is discussed by the show's host and a group of lay guests. Two narratives in particular are examined for their similarities and differences. Both are structured around the idea of a 'turning point' that results in successful recovery from obesity, although what constitutes recovery differs in both cases, and is linked to the overall structure of the narrative. It is argued that personal narratives are important conceptual tools for health psychologists to work with, although we cannot lose sight of the mediated context in which these data are produced.

Eyewitness evidence and the confidence the eyewitness expresses in such evidence are crucial in many criminal trials. The present study is an examination of the influence of confusing questions often used by attorneys to examine witnesses in court. Participants viewed a videotaped incident and were questioned about the incident 1 week later. Half the participants were asked questions framed in a confusing form; the remaining half were asked the same questions in straightforward language. Confusing questions reduced the participant witnesses' accuracy and suppressed the confidence-accuracy relationships compared with the condition in which simple questions were asked. However, the number of absolutely sure responses was the same in both conditions, although these responses were almost always accurate in the simplified condition, whereas in the confusing question condition, accuracy was comparatively poor. This experiment demonstrates the importance of ensuring that lawyers ask witnesses simple, clear questions.

Gross dissection anatomical studies have investigated the course of the human lumbar posterior primary ramus and its branches. This nerve has frequently been associated with low back pain; however, the cross-sectional area of the space beneath the mamillo-accessory ligament, which is occupied by the medial branch of the posterior primary ramus, has not been clearly defined. The purpose of this study is to use a histological procedure to identify the cross-sectional area of the space beneath the mamillo-accessory ligament which is occupied by the medial branch of the posterior primary ramus as it passes en route to the zygapophyseal joint capsules. The main findings are that the medial branch of the posterior primary ramus occupies only a small percentage (approximately 3%) of the space enclosed by the mamillo-accessory ligament, and that it is surrounded by adipose tissue which provides an adequate protective "cushion" around it. Therefore, it is unlikely that the medial branch of the posterior primary ramus could be trapped beneath the mamillo-accessory ligament and cause pain.