312 results on '"Gilchrist, D"'
Search Results
2. The development of a procedure for the inspection of unlined rock service tunnels
- Author
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Australasian Tunnelling Conference (15th : 2014 : Sydney, NSW) and Gilchrist, D
- Published
- 2014
3. Shotcrete in the construction of Pen-Y-Clip tunnel, North Wales
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Hobson, D. A., Gilchrist, D. C., Arthur, L. J., Darby, A. W., Rafoneke, B., Daws, Graham, MacDonald, Dan, Innaurato, Nicola, Mancini, Renato, Rondena, Enrico, Zaninetti, Attilio, Coutts, A. W. P., Davies, H. R., Curtis, R. S., Finch, A. P., Lovat, R. P., Deane, A. P., Burgess, K. T., Knights, M. C., Oswell, M. A., Farmer, I. W., Mak, B. W. L., Morfeldt, Daniel, Martin, C. J. H., Pakes, G., Finnsson, Sigurdur, Janzon, H. A., Laughton, C., Nelson, P. P., Abd Al-Jalil, Y., Remington, R., Caspe, H. P., Kim, A. Y., Bergen, L. J., Araujo, J. R., Harpf, Richard, Axhausen, Klaus, Hellings, J. E., Mair, R. J., Harris, D. I., Love, J. P., Blakey, D., Kettle, C., New, B. M., Bowers, K. H., Aarvold, Vidar, Chudleigh, I. L. J., Webb, N. S., Featherstone, G. A., Bandmann, Manfred, Ramisch, H., Beckmann, Uwe, Cole, B. J., Lees, H. J., Dietz, Walter, Fawcett, D. F., Chapman, P. J., Barratt, D. A., O’Reilly, M. P., Temporal, John, Baston-Pitt, Jon, Fredriksen, F. J., Aabøe, Roald, Hasle, G. J., Hobson, D. A., Gilchrist, D. C., Jancsecz, Sandor, Steiner, Walter, Farrow, J. P., Claye, P. M., Warren, R. B., Ginary, M. A., Matthews, R., Kruizenga, H., Weeks, C. R., Winterton, T. R., Leblais, Y., Leblond, L., Malios, Yannis, Peron, J. Y., Marcheselli, P., Catling, P., Scholey, J., Murray, A. D., Marrai, Bruno, Davies, P. G., Tibau, Guilherme, Gutenwik, Erik, Santana, Maurício, Pellegri, Pierre Jean, Fowell, R. J., Richardson, G., Gollick, M. J., Beatty, J. G., Ganey, R. J., and Killingsworth, J. E.
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- 1994
- Full Text
- View/download PDF
4. Should We Change the Way We Think About Market Performance When It Comes to Quasi-Markets? A New Framework for Evaluating Public Service Markets
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Dickinson, H, Carey, G, Malbon, E, Gilchrist, D, Chand, S, Kavanagh, A, Alexander, D, Dickinson, H, Carey, G, Malbon, E, Gilchrist, D, Chand, S, Kavanagh, A, and Alexander, D
- Abstract
Markets are increasingly used by governments to deliver social services, underpinned by the belief that they can drive efficiency and quality. These ‘quasi‐markets' require on‐going management to ensure they meet policy goals, and address issues of market inequity. This has seen debates emerge around ‘market stewardship' and ‘market shaping’ that center on how best to manage markets toward optimal policy outcomes. At present, there is a significant gap in both literature and practice with regard to what types of actions are most effective for market stewardship. In this article, we outline a framework that helps diagnose different quasi‐market problems. We delineate two dimensions of public service quasi‐markets—sufficiency and diversity—using the example of a disability personalization market to show how this framework can unpack different types of quasi‐market states. Lastly, we outline the types of interventions that might be adopted to help deal with ineffective quasi‐markets. Evidence for Practice Market mechanisms are increasing being used by governments around the world to drive innovation and efficacies. Increasingly it is being recognized that these markets need intervention in order to meet policy goals. This paper provides a framework for conceptualizing types of market problems, and offers solutions for the scenarios outlined.
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- 2022
5. Charles Harper through a Galbraithian lens: Agricultural cooperation and countervailing power in colonial Western Australia
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Gilchrist, D. J.
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- 2011
6. Histories of Fascism and Anti-Fascism in Australia ed. by Evan Smith, Jayne Persian, and Vashti Jane Fox (review)
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Gilchrist, David
- Published
- 2024
7. Breastfeeding and health promotion: the experience of Aboriginal and non-Aboriginal mothers
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Smith, H, Woods, B, Gracey, M, Gilchrist, D, Binns, CW, and Scott, J
- Published
- 2004
8. Breeding for Disease and Nematode Resistance
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Elgin, J. H., primary, Welty, R.E., additional, and Gilchrist, D. B., additional
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- 2015
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9. Albert Fink and the Pooling System
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Gilchrist, D. T.
- Published
- 1960
10. Should we change the way we think about market performance when it comes to quasi-markets? A new framework for evaluating public service markets
- Author
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Dickinson, H, Carey, G, Malbon, E, Gilchrist, D, Chand, S, Kavanagh, A, Alexander, D, Dickinson, H, Carey, G, Malbon, E, Gilchrist, D, Chand, S, Kavanagh, A, and Alexander, D
- Abstract
Markets are increasingly used by governments to deliver social services, underpinned by the belief that they can drive efficiency and quality. These ‘quasi-markets' require on-going management to ensure they meet policy goals, and address issues of market inequity. This has seen debates emerge around ‘market stewardship' and ‘market shaping’ that center on how best to manage markets toward optimal policy outcomes. At present, there is a significant gap in both literature and practice with regard to what types of actions are most effective for market stewardship. In this article, we outline a framework that helps diagnose different quasi-market problems. We delineate two dimensions of public service quasi-markets—sufficiency and diversity—using the example of a disability personalization market to show how this framework can unpack different types of quasi-market states. Lastly, we outline the types of interventions that might be adopted to help deal with ineffective quasi-markets.
- Published
- 2021
11. NEAD Chains in Transplantation
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Ashlagi, I., Gilchrist, D. S., Roth, A. E., and Rees, M. A.
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- 2011
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12. Nonsimultaneous Chains and Dominos in Kidney- Paired Donation—Revisited
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Ashlagi, I., Gilchrist, D. S., Roth, A. E., and Rees, M. A.
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- 2011
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13. High acceleration impulsive rotations reveal severe long-term deficits of the horizontal vestibulo-ocular reflex in the guinea pig
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Gilchrist, D. P. D., Curthoys, Ian S., Cartwright, Andrew D., Burgess, Ann M., Topple, Ann N., and Halmagyi, Michael
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- 1998
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14. Family history as a predictor of uptake of cancer preventive procedures by women with a BRCA1 or BRCA2 mutation
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Metcalfe, K A, Foulkes, W D, Kim-Sing, C, Ainsworth, P, Rosen, B, Armel, S, Poll, A, Eisen, A, Gilchrist, D, Chudley, A, Ghadirian, P, Maugard, C, Lemire, E G, Sun, P, and Narod, S A
- Published
- 2008
15. Constitutive deficiency in DNA mismatch repair: is it time for Lynch III?
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Felton, K EA, Gilchrist, D M, and Andrew, S E
- Published
- 2007
16. The consequences of the current public sector reporting framework for government accountability and decision making
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Pilcher, R, Gilchrist, D, Mack, Janet, Pilcher, R, Gilchrist, D, and Mack, Janet
- Abstract
In this chapter, the changes that have occurred in the Australian government’s(Commonwealth) accounting systems and its reporting/disclosure regimes over the last 30 years and the consequential effects on accountability will be considered. Many of these changes result from a combination of several factors (Broadbent & Guthrie 1992; Ryan 1995). One of the factors proposed as being a catalyst for the changes is the emergence of the ‘new right’ and its promotion of market solutions to public sector resourcing problems (Hood 1991). Whilst the focus here is on the Australian Commonwealth government, it is also relevant to the various state governments within Australia that have adopted similar changes and to international jurisdictions since these changes have also occurred in other western democracies. As an example, accrual accounting, badged as resource accounting, was introduced in the United Kingdom (UK) in 2001 (Connolly & Hyndman 2006). There were in the UK, as there had been in Australia, concerns about the ability of accrual accounting to deliver effective accountability mechanisms (Carlin 2005).
- Published
- 2019
17. Factors associated with the initiation of breast-feeding by Aboriginal mothers in Perth
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Binns, C, Gilchrist, D, Gracey, M, Zhang, M, Scott, J, and Lee, A
- Published
- 2004
18. Cost analysis of DNA-based testing in a large Canadian family with multiple endocrine neoplasia type 2
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Gilchrist, D M, Morrish, D W, Bridge, P J, and Brown, J L
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- 2004
19. Germline E-cadherin mutations in hereditary diffuse gastric cancer: assessment of 42 new families and review of genetic screening criteria
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Brooks-Wilson, A R, Kaurah, P, Suriano, G, Leach, S, Senz, J, Grehan, N, Butterfield, Y S N, Jeyes, J, Schinas, J, Bacani, J, Kelsey, M, Ferreira, P, MacGillivray, B, MacLeod, P, Micek, M, Ford, J, Foulkes, W, Australie, K, Greenberg, C, LaPointe, M, Gilpin, C, Nikkel, S, Gilchrist, D, Hughes, R, Jackson, C E, Monaghan, K G, Oliveira, M J, Seruca, R, Gallinger, S, Caldas, C, and Huntsman, D
- Published
- 2004
20. Shotcrete in the construction of Pen-Y-Clip tunnel, North Wales
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Hobson, D. A., primary and Gilchrist, D. C., additional
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- 1994
- Full Text
- View/download PDF
21. Tunnelling’ 94
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Arthur, L. J., primary, Darby, A. W., additional, Rafoneke, B., additional, Daws, Graham, additional, MacDonald, Dan, additional, Innaurato, Nicola, additional, Mancini, Renato, additional, Rondena, Enrico, additional, Zaninetti, Attilio, additional, Coutts, A. W. P., additional, Davies, H. R., additional, Curtis, R. S., additional, Finch, A. P., additional, Lovat, R. P., additional, Deane, A. P., additional, Burgess, K. T., additional, Knights, M. C., additional, Oswell, M. A., additional, Farmer, I. W., additional, Mak, B. W. L., additional, Morfeldt, Daniel, additional, Martin, C. J. H., additional, Pakes, G., additional, Finnsson, Sigurdur, additional, Janzon, H. A., additional, Laughton, C., additional, Nelson, P. P., additional, Abd Al-Jalil, Y., additional, Remington, R., additional, Caspe, H. P., additional, Kim, A. Y., additional, Bergen, L. J., additional, Araujo, J. R., additional, Harpf, Richard, additional, Axhausen, Klaus, additional, Hellings, J. E., additional, Mair, R. J., additional, Harris, D. I., additional, Love, J. P., additional, Blakey, D., additional, Kettle, C., additional, New, B. M., additional, Bowers, K. H., additional, Aarvold, Vidar, additional, Chudleigh, I. L. J., additional, Webb, N. S., additional, Featherstone, G. A., additional, Bandmann, Manfred, additional, Ramisch, H., additional, Beckmann, Uwe, additional, Cole, B. J., additional, Lees, H. J., additional, Dietz, Walter, additional, Fawcett, D. F., additional, Chapman, P. J., additional, Barratt, D. A., additional, O’Reilly, M. P., additional, Temporal, John, additional, Baston-Pitt, Jon, additional, Fredriksen, F. J., additional, Aabøe, Roald, additional, Hasle, G. J., additional, Hobson, D. A., additional, Gilchrist, D. C., additional, Jancsecz, Sandor, additional, Steiner, Walter, additional, Farrow, J. P., additional, Claye, P. M., additional, Warren, R. B., additional, Ginary, M. A., additional, Matthews, R., additional, Kruizenga, H., additional, Weeks, C. R., additional, Winterton, T. R., additional, Leblais, Y., additional, Leblond, L., additional, Malios, Yannis, additional, Peron, J. Y., additional, Marcheselli, P., additional, Catling, P., additional, Scholey, J., additional, Murray, A. D., additional, Marrai, Bruno, additional, Davies, P. G., additional, Tibau, Guilherme, additional, Gutenwik, Erik, additional, Santana, Maurício, additional, Pellegri, Pierre Jean, additional, Fowell, R. J., additional, Richardson, G., additional, Gollick, M. J., additional, Beatty, J. G., additional, Ganey, R. J., additional, and Killingsworth, J. E., additional
- Published
- 1994
- Full Text
- View/download PDF
22. Just Do It? A Cautionary Tale on Implementing Performance Management Regimes.
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Pilcher, R, Gilchrist, D, Drew, J, Gamage, S, Pilcher, R, Gilchrist, D, Drew, J, and Gamage, S
- Abstract
There has been a recent trend towards the use of performance indicators – often predicated on financial data – to enhance accountability and transparency of local government both in Australia and abroad. However, performance management also brings with it a range of risks including inter alia unintended performance distortion, synecdochal gap and intended distortions. This chapter reviews the substantial scholarly literature on government performance management before applying the concepts to a particular instance of high stakes performance management: the New South Wales Fit for the Future program. Fit for the Future required councils to self-assess against seven ratios drawn from financial statement data. Councils which failed to achieve the prescribed benchmarks were subject to forced amalgamations. Empirical evidence is provided which suggests significant levels of distortion in the performance management data. It is argued that careful design and testing of ratios – in order to avoid deleterious outcomes – is extremely important in any performance management regime, irrespective of whether accounting data from audited financial statements is used.
- Published
- 2018
23. The intention and the reality: A commentary on the not-for-profit reform agenda in Australia
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Pilcher, Robyn, Gilchrist, D., Pilcher, Robyn, and Gilchrist, D.
- Abstract
The not-for-profit (NFP) sector is a critical part of the social infrastructure of a developed country. It is a sector that has a long history and, in the Australian context, was early recognised by the establishment of legislation designed to facilitate the incorporation of associations. Over time, the legislation in Australia was changed to meet changing perceptions relating to the governance, regulation and supervision of these organisations. The focus of NFP organisations has largely been recognised to be related to mission—NFP organisations are provided tax relief and other advantages as they are seen to provide critical services and supports that enhance our civil society while members cannot appropriate profits or assets generated out of the operations. However, in the last five years or so, the general perception regarding the regulation and supervision of NFP organisations has related to what might be called commercial foci. Part of this change is the result of the increasingly commercial nature of the relationship between government and the NFP sector, wherein government seeks to procure services from the sector commensurate with its policy objectives as they may be from time to time. This chapter examines the development of reform at the national and sub-national levels in Australia related to NFP organisations over time, in order to assess the nature of NFP organisations themselves, the drivers of reform, and the impact such reforms are likely to have on mission priorities in particular. We find that, while NFP organisations are sui generis and have their provenance in mission centricity, without focusing on this mission as part of the regulatory framework, the drift toward commercial values is likely to reduce the suitability of NFP organisations to their social task.
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- 2018
24. Differential Reporting: What Does it Really Mean for the Public Sector?
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Pilcher, Robyn, Gilchrist, D., Pilcher, Robyn, and Gilchrist, D.
- Abstract
The history of accounting can be traced back hundreds of years with double entry accounting first transcribed by Cotrugli and Pacioli in 1458 and 1494 respectively (Yamey 1994). Since then financial reporting, including Generally Accepted Accounting Principles (GAAP), has developed through the centuries. One of the major turning points in the United States (US) was the Great Depression which triggered comprehensive reform beginning in 1930 with the American Institute of Accountants and the New York Stock Exchange reviewing financial reporting requirements (Financial Accounting Foundation n.d.). According to the Financial Accounting Foundation (n.d.), their main aim was the provision of information to aid in decision-making by users. Other countries followed suit, including Australia, always with this same key message as the objective. It is how that information is transmitted that continues to result in much debate amongst accounting standard setting bodies. Differential reporting became topical when the International Accounting Standards Board (IASB) introduced International Financial Reporting Standards (IFRS) for Small and Medium-sized Entities (SMEs) in July 2009. This chapter fills a gap in the current literature by, initially, considering the impact on the public sector in general if a differential reporting system is introduced. Then, it examines more closely the Australian Reduced Disclosure Requirements (RDR) regime—something other countries could consider instead of IFRS for SMEs. Taken in the context of value as defined in this chapter, findings reveal that not all criteria in terms of efficiencies, clarity and transparency, are met. For the public sector there are bigger issues at stake in terms of accountability that neither the IFRS nor RDR have addressed.
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- 2018
25. Public Sector Accounting, Accountability and Governance Globalising the Experiences of Australia and New Zealand
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Pilcher, Robyn, Gilchrist, D., Pilcher, Robyn, and Gilchrist, D.
- Abstract
? Based on rigorous research by top public sector researchers, this edited collection explores how the concepts of accountability, governance and auditing are applied in practice, providing a unique perspective on the global challenges of ...
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- 2018
26. Same, same but different : a comparison between performance audit and operational audit
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Scully, Glennda, Vafaei, E., Gilchrist, D., Singh, H., Scully, Glennda, Vafaei, E., Gilchrist, D., and Singh, H.
- Abstract
It explores the multiple nuances which impact the adoption of governance policies, while reflecting the additional complexity imposed by political factors. ¿ Based on rigorous research by top public sector researchers, this edited ...
- Published
- 2018
27. Public sector audit history in Britain and Australia
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Bunn, M., Pilcher, Robyn, Gilchrist, D., Bunn, M., Pilcher, Robyn, and Gilchrist, D.
- Published
- 2018
28. Social Impact Bonds: The Role of Evaluation
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Gilchrist, D., Wilkins, P., Gilchrist, D., and Wilkins, P.
- Abstract
This chapter focuses on the central role of evaluation in assessing the achievement of outcomes and the challenges. It reviews the nature and structure of a Social Impact Bonds (SIBs). SIBs are very new and in many respects experimental and are likely to remain in that category for some time yet. The public good here equates to an increase in better focused, better managed and more effective human services programs. Barclay and Symons have identified two elements of assessment that need to be undertaken in order for a SIB to be successfully evaluated. The search for interventions suited to the SIB approach raises significant issues for the wider practice of evaluation. As Azemati et al. comment for many social problems, we lack proven, scalable solutions. There may be increased opportunities for focused and rigorous evaluations which are necessary precursors to the negotiation of future SIBs.
- Published
- 2017
29. Accountability for the Public Policy Contribution of Not-for-Profit Organizations: Who is Accountable to Whom, and for What?
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Wilkins, P., Gilchrist, D., Wilkins, P., and Gilchrist, D.
- Abstract
This chapter discusses the key aspects of accountability in relation to the public policy contribution of Not For Profit Organizations (NFPOs). Accountability provides a lens through which we can gain insights into governance of nonstatutory contributions to governments public policy objectives. A review of accountability frameworks for NFPOs observed that there are very few critical eyes looking from the outside; no shareholders, stockbrokers or specific government watchdogs. Many of the entities involved do not operate in the market sector and many of their activities would not be undertaken by the for-profit or government sectors. This is either due to the traditional allocation of government funding to NPFOs or because the funding for service delivery is insufficient and inherently unprofitable. Characteristics of good Not For Profit (NFP) governance which includes a focus on meeting member and stakeholder expectations through accountability, transparency, and disclosure.
- Published
- 2017
30. Mode and Physiological Consequence of Aal-Toxin Interaction with the asc Locus in Tomato
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Gilchrist, D. G., Harada, J. J., Graniti, Antonio, editor, Durbin, Richard D., editor, and Ballio, Alessandro, editor
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- 1989
- Full Text
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31. Metabolic Regulation in Host-Parasite Interactions
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Kosuge, T., Gilchrist, D. G., Pirson, A., editor, Zimmermann, M. H., editor, Heitefuss, R., editor, and Williams, P. H., editor
- Published
- 1976
- Full Text
- View/download PDF
32. Diabetes and breast cancer among women with BRCA1 and BRCA2 mutations
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Bordeleau, L, Lipscombe, L, Lubinski, J, Ghadirian, P, Foulkes, Wd, Neuhausen, S, Ainsworth, P, Pollak, M, Sun, P, Narod, Sa, Hereditary Breast Cancer Clinical Study Group Collaborators: Lynch HT, Eisen, A, Mckinnon, W, Wood, M, Saal, H, Chudley, A, Robidoux, A, Kim Sing, C, Tung, N, Armel, S, Huzarski, T, Provencher, D, Lemire, E, Tulman, A, Llacuachaqui, M, Sweet, K, Gilchrist, D, Karlan, B, Kurz, R, Rosen, B, Demsky, R, Panchal, S, Couch, F, Elser, C, Manoukian, S, Daly, M, Cybulski, C, Gronwald, J, Byrski, T, Olapade, O, Stoppa Lyonnet, D, Weitzel, J, Mclennan, J, Meschino, W, Pasini, Barbara, Singer, C, Dressler, C, Metcalfe, K, Domchek, S, and Isaacs, C.
- Subjects
Adult ,Oncology ,Cancer Research ,medicine.medical_specialty ,Genes, BRCA2 ,BRCA1 ,BRCA2 ,breast cancer ,diabetes ,Genes, BRCA1 ,Antineoplastic Agents ,Breast Neoplasms ,Risk Assessment ,Biochemistry ,Article ,Diabetes mellitus genetics ,Breast cancer ,Risk Factors ,Internal medicine ,Diabetes Mellitus ,medicine ,Hyperinsulinemia ,Humans ,Genetic Predisposition to Disease ,Risk factor ,skin and connective tissue diseases ,Aged ,Aged, 80 and over ,business.industry ,Diabetes ,Obstetrics and Gynecology ,Cancer ,Middle Aged ,medicine.disease ,Risk factors for breast cancer ,Case-Control Studies ,Mutation ,Cancer research ,Female ,Breast disease ,Risk assessment ,business - Abstract
Women with a BRCA1 or BRCA2 mutation face a high lifetime risk of breast cancer.1 It is important to identify risk factors for breast cancer among genetically predisposed women, to devise strategies to minimize the risk. Several lines of evidence link diabetes and breast cancer.2,3 Insulin resistance and hyperinsulinemia, which predispose to diabetes, may increase the risk of breast cancer in the general population,4 and hyperinsulinemia may promote the growth of pre-existing breast neoplasms.5 Furthermore, a high body mass index (BMI) is a risk factor for both breast cancer recurrence and for insulin resistance.6–8 It is also of interest to establish whether diabetes (or any of the drugs used to treat diabetes) influences the risk of breast cancer in BRCA carriers. The risk of future diabetes may also be increased in women after a diagnosis of breast cancer.9 This risk may be mediated by common risk factors, such as high BMI or insulin resistance, or diabetes may be a late effect of breast cancer treatment. It is important to explore the impact of these factors on the risk of diabetes in women with BRCA mutations. In this cohort of BRCA carriers, we sought to determine whether diabetes increases the risk of breast cancer in BRCA carriers, and to identify risk factors for diabetes in this high-risk population.
- Published
- 2010
33. Synovial Fibroblast Proliferation is enhanced by MicroRNA-223 Delivery through Monocyte-derived Microparticles
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Meier, F, Gilchrist, D, Müller-Ladner, U, McInnes, I, Kurowska-Stolarska, M, Meier, F, Gilchrist, D, Müller-Ladner, U, McInnes, I, and Kurowska-Stolarska, M
- Published
- 2016
34. Timing of oral contraceptive use and the risk of breast cancer in BRCA1 mutation carriers
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Kotsopoulos, J, Lubinski, J, Gronwald, J, Cybulski, C, Demsky, R, Neuhausen, Sl, Kim Sing, C, Tung, N, Friedman, S, Senter, L, Weitzel, J, Karlan, B, Moller, P, Sun, P, Narod, Sa, Hereditary Breast Cancer Clinical Study Group: Lynch HT, Singer, C, Eng, C, Mitchell, G, Huzarski, T, Mccuaig, J, Hughes, K, Mills, G, Ghadirian, P, Eisen, A, Gilchrist, D, Blum, Jl, Zakalik, D, Pal, T, Daly, M, Weber, B, Snyder, C, Fallen, T, Chudley, A, Lunn, J, Donenberg, T, Kurz, Rn, Saal, H, Garber, J, Rennert, G, Sweet, K, Gershoni Baruch, R, Rappaport, C, Lemire, E, Stoppa Lyonnet, D, Olopade, Oi, Merajver, S, Bordeleau, L, Cullinane, Ca, Friedman, E, Mckinnon, W, Wood, M, Rayson, D, Meschino, W, Mclennan, J, Costalas, Jw, Reilly, Re, Vadaparampil, S, Offit, K, Kauff, N, Klijn, J, Euhus, D, Kwong, A, Isaacs, C, Couch, F, Manoukian, S, Byrski, T, Elser, C, Panchal, S, Armel, S, Nanda, S, Metcalfe, K, Poll, A, Rosen, B, Foulkes, Wd, Rebbeck, T, Ainsworth, P, Robidoux, A, Warner, E, Maehle, L, Osborne, M, Evans, G, Pasini, Barbara, Ginsburg, O, Cohen, S, Bohdan, G, Jakubowska, A, and Little, J.
- Subjects
Adult ,Heterozygote ,Cancer Research ,medicine.medical_specialty ,Breast Neoplasms ,Breast cancer ,breast cancer ,Risk Factors ,medicine ,Humans ,Genetic Association Studies ,Gynecology ,Oral contraceptives ,BRCA1 Protein ,Obstetrics ,business.industry ,Age Factors ,Case-control study ,Cancer ,Odds ratio ,Middle Aged ,medicine.disease ,BRCA mutations ,Oncology ,Family planning ,Case-Control Studies ,Pill ,Relative risk ,Mutation ,Female ,Ovarian cancer ,business ,Contraceptives, Oral - Abstract
It is not clear if early oral contraceptive use increases the risk of breast cancer among young women with a breast cancer susceptibility gene 1 (BRCA1) mutation. Given the benefit of oral contraceptives for the prevention of ovarian cancer, estimating age-specific risk ratios for oral contraceptive use and breast cancer is important. We conducted a case-control study of 2,492 matched pairs of women with a deleterious BRCA1 mutation. Breast cancer cases and unaffected controls were matched on year of birth and country of residence. Detailed information about oral contraceptive use was collected from a routinely administered questionnaire. Conditional logistic regression was used to estimate the odds ratios (OR) and 95 % confidence intervals (CI) for the association between oral contraceptive and breast cancer, by age at first use and by age at diagnosis. Among BRCA1 mutation carriers, oral contraceptive use was significantly associated with an increased risk of breast cancer for women who started the pill prior to age 20 (OR 1.45; 95 % CI 1.20-1.75; P = 0.0001) and possibly between ages 20 and 25 as well (OR 1.19; 95 % CI 0.99-1.42; P = 0.06). The effect was limited to breast cancers diagnosed before age 40 (OR 1.40; 95 % CI 1.14-1.70; P = 0.001); the risk of early-onset breast cancer increased by 11 % with each additional year of pill use when initiated prior to age 20 (OR 1.11; 95 % CI 1.03-1.20; P = 0.008). There was no observed increase for women diagnosed at or after the age of 40 (OR 0.97; 95 % CI 0.79-1.20; P = 0.81). Oral contraceptive use before age 25 increases the risk of early-onset breast cancer among women with a BRCA1 mutation and the risk increases with duration of use. Caution should be taken when advising women with a BRCA1 mutation to take an oral contraceptive prior to age 25.
- Published
- 2014
35. The impact of pregnancy on breast cancer survival in women who carry a BRCA1 or BRCA2 mutation
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Valentini, A, Lubinski, J, Byrski, T, Ghadirian, P, Moller, P, Lynch, Ht, Ainsworth, P, Neuhausen, Sl, Weitzel, J, Singer, Cf, Olopade, Oi, Saal, H, Lyonnet, Ds, Foulkes, Wd, Kim Sing, C, Manoukian, S, Zakalik, D, Armel, S, Senter, L, Eng, C, Grunfeld, E, Chiarelli, Am, Poll, A, Sun, P, Narod, Sa, Hereditary Breast Cancer Clinical Study Group: Gronwald, J, Cybulski, C, Huzarski, T, Robidoux, A, Offit, K, Gershoni Baruch, R, Isaacs, C, Tung, N, Rosen, B, Demsky, R, Mccuaig, J, Eisen, A, Bordeleau, L, Karlan, B, Garber, J, Gilchrist, D, Couch, F, Evans, G, Kwong, A, Maehle, L, Friedman, E, Mckinnon, W, Wood, M, Daly, M, Blum, Jl, Robson, M, Chudley, A, Panchal, S, Mclennan, J, Pasini, Barbara, Rennert, G, Lunn, J, Fallen, T, Rayson, D, Smith, M, Ginsburg, O, Lemire, E, Meschino, W, Vadaparampil, S, Euhus, D, Costalas, Jw, Donenberg, T, Kurz, Rn, Friedman, S, Sweet, K, Cullinane, Ca, Reilly, Re, Kotsopoulos, J, Nanda, S, and Metcalfe, K.
- Subjects
Oncology ,Cancer Research ,medicine.medical_specialty ,Heterozygote ,Survival ,Genes, BRCA2 ,Genes, BRCA1 ,Breast Neoplasms ,Article ,Cohort Studies ,Breast cancer ,Pregnancy ,Risk Factors ,Internal medicine ,Medicine ,Humans ,skin and connective tissue diseases ,Survival rate ,business.industry ,Proportional hazards model ,Hazard ratio ,BRCA mutation ,BRCA mutations ,Case-control study ,medicine.disease ,Case-Control Studies ,Mutation ,Female ,business ,Cohort study - Abstract
Physicians are often approached by young women with a BRCA mutation and a recent history of breast cancer who wish to have a baby. They wish to know if pregnancy impacts upon their future risks of cancer recurrence and survival. To date, there is little information on the survival experience of women who carry a mutation in one of the BRCA genes and who become pregnant. From an international multi-center cohort study of 12,084 women with a BRCA1 or BRCA2 mutation, we identified 128 case subjects who were diagnosed with breast cancer while pregnant or who became pregnant after a diagnosis of breast cancer. These women were age-matched to 269 mutation carriers with breast cancer who did not become pregnant (controls). Subjects were followed from the date of breast cancer diagnosis until the date of last follow-up or death from breast cancer. The Kaplan–Meier method was used to estimate 15-year survival rates. The hazard ratio for survival associated with pregnancy was calculated using a left-truncated Cox proportional hazard model, adjusting for other prognostic factors. Among women who were diagnosed with breast cancer when pregnant or who became pregnant thereafter, the 15-year survival rate was 91.5 %, compared to a survival of 88.6 % for women who did not become pregnant (adjusted hazard ratio = 0.76; 95 % CI 0.31–1.91; p = 0.56). Pregnancy concurrent with or after a diagnosis of breast cancer does not appear to adversely affect survival among BRCA1/2 mutation carriers.
- Published
- 2013
36. October 28, 2011
- Author
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Rothenmund, H., Singh, H., Candas, B., Chodirker, B.N., Serfas, K., Aronson, M., Holter, S., Volenik, A., Green, J., Dicks, E., Woods, M.O., Gilchrist, D., Gryfe, R., Cohen, Z., and Foulkes, W.D.
- Subjects
Canada ,Lynch syndrome ,hereditary cancer ,familial adenomatous polyposis ,education ,cancer registry ,Colorectal cancer ,MUTYH-associated polyposis ,colorectal cancer screening - Abstract
At a consensus meeting held in Montreal, October 28, 2011, a multidisciplinary group of Canadian experts in the fields of genetics, gastroenterology, surgery, oncology, pathology, and health care services participated in presentation and discussion sessions for the purpose of developing consensus statements pertaining to the development and maintenance of hereditary colorectal cancer registries in Canada. Five statements were approved by all participants.
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- 2013
- Full Text
- View/download PDF
37. Parental origin of mutation and the risk of breast cancer in a prospective study of women with a BRCA1 or BRCA2 mutation
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Senst, N, Llacuachaqui, M, Lubinski, J, Lynch, H, Armel, S, Neuhausen, S, Ghadirian, P, Sun, P, Narod, Sa, Hereditary Breast Cancer Study Group: Panchal, S, Rosen, B, Demsky, R, Foulkes, Wd, Kim Sing, C, Singer, C, Short, T, Senter, L, Sweet, K, Tung, N, Ainsworth, P, Eisen, A, Gilchrist, D, Bordeleau, L, Olopade, Oi, Karlan, B, Kurz, R, Couch, F, Manoukian, S, Daly, M, Saal, H, Mckinnon, W, Wood, M, Elser, C, Eng, C, Weitzel, J, Mclennan, J, Lemire, E, Fallen, T, Kaklamani, V, Stoppa Lyonnet, D, Isaacs, C, Rayson, D, Ginsburg, O, Chudley, A, Pasini, Barbara, Zakalik, D, Cullinane, Ca, Pal, T, Vadaparampil, S, Friedman, S, Meschino, W, Moller, P, Maehle, L, Valentini, A, Ragone, A, Poll, A, and Nanda, S.
- Subjects
Adult ,BRCA2 Protein ,Risk ,parental origin ,BRCA1 Protein ,Inheritance Patterns ,Breast Neoplasms ,Middle Aged ,BRCA mutations ,Pedigree ,Young Adult ,breast cancer ,Mutation ,Humans ,Female ,Prospective Studies ,Aged ,Proportional Hazards Models - Abstract
The objective is to estimate the risk of breast cancer in women who carry a deleterious BRCA1 or BRCA2 mutation, according to parental origin of mutation. We conducted a cohort study of women with a BRCA1 mutation (n = 1523) or BRCA2 mutation (n = 369) who had not been diagnosed with breast or ovarian cancer. For each woman, the pedigree was reviewed and the origin of the mutation was assigned as probable paternal or maternal. The hazard ratio (HR) for developing breast cancer in the follow-up period was estimated for women with a paternal mutation compared to a maternal mutation. The risk of breast cancer was modestly higher in women with a paternal BRCA1 mutation compared to women with a maternal BRCA1 mutation (HR = 1.46; 95% CI = 0.99-2.16) but the difference was not significant (p = 0.06). The parental mutation origin did not affect the risk in women with a BRCA2 mutation. Our results are consistent with the hypothesis that there is an increased risk of breast cancer among women with a paternally inherited BRCA1 mutation compared to a maternally inherited mutation. However, the data are not sufficiently compelling to justify different screening recommendations for the two subgroups.
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- 2012
38. An assessment of the native and invasive horticultural plants sold in the mid-Atlantic region
- Author
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Coombs, George, Gilchrist, Denise, and Watson, Patricia
- Published
- 2020
39. BRCA1 and BRCA2 families and the risk of skin cancer
- Author
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Ginsburg, Om, Kim Sing, C, Foulkes, Wd, Ghadirian, P, Lynch, Ht, Sun, P, Narod, Sa, Hereditary Breast Cancer Clinical Study Group: Olopade, Oi, Tung, N, Couch, F, Rosen, B, Friedman, E, Eisen, A, Domchek, S, Stoppa Lyonnet, D, Gershoni Baruch, R, Horsman, D, Wagner, T, Saal, H, Meschino, W, Offit, K, Trivedi, A, Robson, M, Osborne, M, Gilchrist, D, Eng, C, Weitzel, J, Mckinnon, W, Wood, M, Pasini, Barbara, Ainsworth, P, Daly, M, Garber, J, Sweet, K, Fallen, T, Karlan, B, Kurz, R, Isaacs, C, Neuhausen, S, Manoukian, S, Armel, S, Demsky, R, Lemire, E, Mclennan, J, and Evans, G.
- Subjects
Oncology ,Male ,Cancer Research ,medicine.medical_specialty ,Heterozygote ,Skin Neoplasms ,endocrine system diseases ,Risk Factors ,Internal medicine ,Epidemiology ,Genetics ,medicine ,Carcinoma ,Skin cancer ,Humans ,Basal cell carcinoma ,Genetic Predisposition to Disease ,Genetic Testing ,skin and connective tissue diseases ,Melanoma ,Genetics (clinical) ,Genetic testing ,BRCA2 Protein ,medicine.diagnostic_test ,business.industry ,BRCA1 Protein ,Cancer ,Odds ratio ,medicine.disease ,BRCA1 ,BRCA2 ,Cohort study ,Pedigree ,Carcinoma, Basal Cell ,Mutation ,Female ,business ,Follow-Up Studies - Abstract
BRCA1 and BRCA2 mutation carriers have elevated risks of breast and ovarian cancers. The risks for cancers at other sites remain unclear. Melanoma has been associated with BRCA2 mutations in some studies, however, few surveys have included non-melanoma skin cancer. We followed 2729 women with a BRCA1 or BRCA2 mutation for an average of 5.0 years. These women were asked to report new cases of cancer diagnosed in themselves or in their family. The risks of skin cancer were compared for probands with BRCA1 and BRCA2 mutations. Of 1779 women with a BRCA1 mutation, 29 developed skin cancer in the follow-up period (1.6%). Of the 950 women with a BRCA2 mutation, 28 developed skin cancer (3.0%) (OR = 1.83 for BRCA2 versus BRCA1; 95% CI 1.08-3.10; P = 0.02). The odds ratio for basal cell carcinoma was higher (OR = 3.8; 95% CI 1.5-9.4; P = 0.002). BRCA2 mutation carriers are at increased risk for skin cancer, compared with BRCA1 carriers, in particular for basal cell carcinoma.
- Published
- 2010
40. Nonlocal normal modes in nanoscale dynamical systems
- Author
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Adhikari, S., primary, Gilchrist, D., additional, Murmu, T., additional, and McCarthy, M.A., additional
- Published
- 2015
- Full Text
- View/download PDF
41. Hormone therapy and the risk of breast cancer in BRCA1 mutation carriers
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Eisen, A, Lubinski, J, Gronwald, J, Moller, P, Lynch, Ht, Klijn, J, Kim Sing, C, Neuhausen, Sl, Gilbert, L, Ghadirian, P, Manoukian, S, Rennert, G, Friedman, E, Isaacs, C, Rosen, E, Rosen, B, Daly, M, Sun, P, Narod, Sa, Hereditary, Breast Cancer Clinical Study Group, Collaborators: Olopade, O, Cummings, S, Tung, N, Couch, F, Foulkes, Wd, Domchek, S, Stoppa Lyonnet, D, Gershoni Baruch, R, Horsman, D, Wagner, T, Saal, H, Warner, E, Meschino, W, Offit, K, Trivedi, A, Robson, M, Osborne, M, Gilchrist, D, Eng, C, Weitzel, J, Mckinnon, W, Wood, M, Maugard, C, Pasini, Barbara, Ainsworth, P, Sweet, K, Pasche, B, Fallen, T, Karlan, B, Kurz, Rn, Armel, S, Tulman, A, Lemire, E, Mclennan, J, Evans, G, Byrski, T, Huzarski, T, Shulman, L., and Medical Oncology
- Subjects
Oncology ,Cancer Research ,medicine.medical_treatment ,BRCA ,Genes, BRCA1 ,cancer risk ,0302 clinical medicine ,Risk Factors ,Surveys and Questionnaires ,Odds Ratio ,skin and connective tissue diseases ,030219 obstetrics & reproductive medicine ,Estrogen Replacement Therapy ,Hormone replacement therapy (menopause) ,Confounding Factors, Epidemiologic ,Articles ,Middle Aged ,3. Good health ,Menopause ,Postmenopause ,030220 oncology & carcinogenesis ,Female ,Breast disease ,medicine.medical_specialty ,Breast Neoplasms ,Risk Assessment ,03 medical and health sciences ,breast cancer ,Breast cancer ,SDG 3 - Good Health and Well-being ,Internal medicine ,medicine ,Humans ,Risk factor ,Hormone therapy ,Aged ,Gynecology ,business.industry ,Oophorectomy ,Cancer ,Estrogens ,Odds ratio ,medicine.disease ,Case-Control Studies ,Sample Size ,Multivariate Analysis ,Mutation ,Progestins ,business - Abstract
Background: Hormone therapy (HT) is commonly given to women to alleviate the climacteric symptoms associated with menopause. There is concern that this treatment may increase the risk of breast cancer. The potential association of HT and breast cancer risk is of particular interest to women who carry a mutation in BRCA1 because they face a high lifetime risk of breast cancer and because many of these women take HT after undergoing prophylactic surgical oophorectomy at a young age. Methods: We conducted a matched case-control study of 472 postmenopausal women with a BRCA1 mutation to examine whether or not the use of HT is associated with subsequent risk of breast cancer. Breast cancer case patients and control subjects were matched with respect to age, age at menopause, and type of menopause (surgical or natural). Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated with conditional logistic regression. Statistical tests were two-sided. Results: In this group of BRCA1 mutation carriers, the adjusted OR for breast cancer associated with ever use of HT compared with never use was 0.58 (95% CI = 0.35 to 0.96; P =. 03). In analyses by type of HT, an inverse association with breast cancer risk was observed with use of estrogen only (OR = 0.51, 95% CI = 0.27 to 0.98; P =. 04); the association with use of estrogen plus progesterone was not statistically significant (OR = 0.66, 95% CI = 0.34 to 1.27; P =. 21). Conclusion: Among postmenopausal women with a BRCA1 mutation, HT use was not associated with increased risk of breast cancer; indeed, in this population, it was associated with a decreased risk.
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- 2008
42. Smoking and the risk of breast cancer in BRCA1 and BRCA2 carriers: an update
- Author
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Ginsburg, O, Ghadirian, P, Lubinski, J, Cybulski, C, Lynch, H, Neuhausen, S, Kim Sing, C, Robson, M, Domchek, S, Isaacs, C, Klijn, J, Armel, S, Foulkes, Wd, Tung, N, Moller, P, Sun, P, Narod, Sa, Olopade, O, Cummings, S, Couch, F, Rosen, B, Stoppa Lyonnet, D, Gershoni Baruch, R, Horsman, D, Wagner, T, Saal, H, Warner, E, Meschino, W, Offit, K, Trivedi, A, Osborne, M, Gilchrist, D, Eng, C, Weitzel, J, Mckinnon, W, Wood, M, Maugard, C, Pasini, Barbara, Ainsworth, P, Sweet, K, Pasche, B, Karlan, B, Kurz, Rn, Tulman, A, Lemire, E, Mclennan, J, Evans, G, Byrski, T, Huzarski, T, Gronwald, J, Gorski, B, Friedman, E, Eisen, A, Daly, M, Garber, J, and Merajver, S.
- Subjects
Adult ,Cancer Research ,medicine.medical_specialty ,Heterozygote ,endocrine system diseases ,Adolescent ,Epidemiology ,Genes, BRCA2 ,Genes, BRCA1 ,Breast Neoplasms ,Biochemistry ,Article ,Young Adult ,Breast cancer ,breast cancer ,Mutation Carrier ,Risk Factors ,80 and over ,medicine ,Humans ,Young adult ,skin and connective tissue diseases ,risk ,Aged ,Gynecology ,Aged, 80 and over ,Obstetrics ,business.industry ,BRCA mutation ,Smoking ,Case-control study ,Cancer ,Odds ratio ,Middle Aged ,medicine.disease ,BRCA1 ,BRCA2 ,smoking ,Genes ,Oncology ,Case-Control Studies ,Mutation ,Female ,Breast disease ,business - Abstract
Among women with a mutation in BRCA1 or BRCA2, the risk of breast cancer is high, but it may be modified by exogenous and endogenous factors. There is concern that exposure to carcinogens in cigarette smoke may increase the risk of cancer in mutation carriers. We conducted a matched case-control study of 2,538 cases of breast cancer among women with a BRCA1 (n = 1,920) or a BRCA2 (n = 618) mutation. One non-affected mutation carrier control was selected for each case, matched on mutation, country of birth, and year of birth. Odds ratios were calculated using conditional logistic regression, adjusted for oral contraceptive use and parity. Ever-smoking was not associated with an increased breast cancer risk among BRCA1 carriers (OR = 1.09; 95% CI 0.95-1.24) or among BRCA2 carriers (OR = 0.81; 95% CI 0.63-1.05). The result did not differ when cases were restricted to women who completed the questionnaire within two years of diagnosis. A modest, but significant increase in risk was seen among BRCA1 carriers with a past history of smoking (OR = 1.27; 95% CI 1.06-1.50), but not among current smokers (OR = 0.95; 0.81-1.12). There appears to be no increase in the risk of breast cancer associated with current smoking in BRCA1 or BRCA2 carriers. There is a possibility of an increased risk of breast cancer among BRCA1 carriers associated with past smoking. There may be different effects of carcinogens in BRCA mutation carriers, depending upon the timing of exposure.
- Published
- 2008
43. Physiological Changes Associated With AAL-Toxin Induced Necrosis in Tomato
- Author
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Moussatos, V. V., primary and Gilchrist, D. G., additional
- Published
- 1989
- Full Text
- View/download PDF
44. Tamoxifen and contralateral breast cancer in BRCA1 and BRCA2 carriers: an update
- Author
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Gronwald, Jacek, Tung, Nadine, Foulkes, William D., Offit, Kenneth, Gershoni, Ruth, Daly, Mary, Kim-Sing, Charmaine, Olsson, Hakan, Ainsworth, Peter, Eisen, Andrea, Saal, Howard, Friedman, Eitan, Olopade, Olufunmilayo, Osborne, Michael, Weitzel, Jeffrey, Lynch, Henry, Ghadirian, Parviz, Lubinski, Jan, Sun, Ping, Narod, Steven A., Gilchrist, D., Weber, B., Rebbeck, T., Isaacs, C., Neuhausen, S., Garber, J., Karlan, B., Fishman, D., Merajver, S., McKinnon, W., Wood, M., Evans, G., Moller, P., Pasini, B., Sweet, K., Eng, C., Rennert, G., Couch, F., McLennan, J., and Provencher, D.
- Subjects
Oncology ,Adult ,Cancer Research ,medicine.medical_specialty ,Oophorectomy ,Antineoplastic Agents, Hormonal ,medicine.medical_treatment ,breast cancer ,BRCA1 ,BRCA2 ,tamoxifen ,DNA Mutational Analysis ,Genes, BRCA2 ,Genes, BRCA1 ,Breast Neoplasms ,Risk Assessment ,Functional Laterality ,Breast cancer ,Internal medicine ,medicine ,Odds Ratio ,Humans ,Genetic Predisposition to Disease ,Risk factor ,skin and connective tissue diseases ,Retrospective Studies ,Gynecology ,business.industry ,Case-control study ,Retrospective cohort study ,Neoplasms, Second Primary ,Odds ratio ,Middle Aged ,Antiestrogen ,medicine.disease ,Pedigree ,Tamoxifen ,Premenopause ,Case-Control Studies ,Female ,business ,medicine.drug - Abstract
Women with a mutation in BRCA1 or BRCA2 face a lifetime risk of breast cancer of approximately 80%, and following the first diagnosis the 10-year risk of contralateral breast cancer is approximately 30%. It has been shown that both tamoxifen and oophorectomy prevent contralateral breast cancer, but it is not clear whether there is a benefit in giving tamoxifen to women who have previously undergone an oophorectomy. Furthermore, the relative degree of protection in BRCA1 and BRCA2 carriers has not been well evaluated. We studied 285 women with bilateral breast cancer and a BRCA1 or BRCA2 mutation, and 751 control women with unilateral breast cancer and a BRCA1 or BRCA2 mutation in a matched case-control study. Control women were of similar age and had a similar age of diagnosis of breast cancer and had been followed for as long as the case for a second primary breast cancer. The history of tamoxifen use for treating the first breast cancer was compared between bilateral and unilateral cases. The multivariate odds ratio for contralateral breast cancer associated with tamoxifen use was 0.50 for carriers of BRCA1 mutations (95% CI, 0.30-0.85) and was 0.42 for carriers of BRCA2 mutations (95% CI, 0.17-1.02). The protective effect of tamoxifen was not seen among women who had undergone an oophorectomy (OR = 0.83; 95%CI, 0.24-2.89) but this subgroup was small. In contrast, a strong protective effect of tamoxifen was apparent among women who were premenopausal or who had undergone natural menopause (OR = 0.44; 95% CI, 0.27-0.65).
- Published
- 2005
45. Structural Changes in the Vestibular Epithelia in Elderly Monkeys and Humans
- Author
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Engstr�m, H., primary, Ades, H. W., additional, Engstr�m, B., additional, Gilchrist, D., additional, and Bourne, G., additional
- Full Text
- View/download PDF
46. NONLOCAL MODAL ANALYSIS FOR NANOSCALE DYNAMICAL SYSTEMS
- Author
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Adhikari, S., primary, Gilchrist, D., additional, Murmu, T., additional, and McCarthy, M., additional
- Published
- 2014
- Full Text
- View/download PDF
47. Nonsimultaneous Chains and Dominos in Kidney- Paired Donation—Revisited
- Author
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Sloan School of Management, Ashlagi, Itai, Gilchrist, D. S., Roth, A. E., Rees, M. A., Sloan School of Management, Ashlagi, Itai, Gilchrist, D. S., Roth, A. E., and Rees, M. A.
- Abstract
Since 2008, kidney exchange in America has grown in part from the incorporation of nondirected donors in transplant chains rather than simple exchanges. It is controversial whether these chains should be performed simultaneously ‘domino-paired donation’, (DPD) or nonsimultaneously ‘nonsimultaneous extended altruistic donor, chains (NEAD). NEAD chains create ‘bridge donors’ whose incompatible recipients receive kidneys before the bridge donor donates, and so risk reneging by bridge donors, but offer the opportunity to create more transplants by overcoming logistical barriers inherent in simultaneous chains. Gentry et al. simulated whether DPD or NEAD chains would produce more transplants when chain segment length was limited to three transplants, and reported that DPD performed at least as well as NEAD chains. As this finding contrasts with the experience of several groups involved in kidney-paired donation, we performed simulations that allowed for longer chain segments and used actual patient data from the Alliance for Paired Donation. When chain segments of 4–6 transplants are allowed in the simulations, NEAD chains produce more transplants than DPD. Our simulations showed not only more transplants as chain length increased, but also that NEAD chains produced more transplants for highly sensitized and blood type O recipients., Alliance for Paired Donation, Novartis (Firm), Genzyme Corporation, F. Hoffmann-La Roche & Co., Pfizer Inc., Astellas Pharma US, National Science Foundation (U.S.) (Grant No. 0616733 to the National Bureau of Economic Research), Life Connection of Ohio, University of Toledo
- Published
- 2011
48. Hormone therapy and the risk of breast cancer in BRCA1 mutation carriers
- Author
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Eisen, A. (Andrea), Lubinski, J. (Jan), Gronwald, J. (Jacek), Moller, P. (Pal), Lynch, H. (Henry), Klijn, J.G.M. (Jan), Kim-Sing, C. (Charmaine), Neuhausen, S.L. (Susan), Gilbert, L. (Lucy), Ghadirian, P. (Parviz), Manoukian, S. (Siranoush), Rennert, G. (Gad), Friedman, E. (Eitan), Isaacs, C. (Claudine), Rosen, B. (Barry), Daly, M.J. (Mark), Sun, P. (Ping), Narod, S. (Steven), Olopade, O.I. (Olofunmilayo), Cummings, S. (Shelly), Tung, N. (Nadine), Couch, F.J. (Fergus), Foulkes, W.D. (William), Domchek, S.M. (Susan), Stoppa-Lyonnet, D. (Dominique), Gershoni-Baruch, R. (Ruth), Horsman, D. (David), Saal, H. (Howard), Warner, E. (Ellen), Meschino, W. (Wendy), Offit, K. (Kenneth), Trivedi, A. (Amber), Robson, M. (Mark), Osborne, M. (Michael), Gilchrist, D. (Dawna), Weitzel, J.N. (Jeffrey), McKinnon, W. (Wendy), Wood, M. (Marie), Maugard, C. (Christine), Pasini, B. (Barbara), Wagner, T. (Teresa), Sweet, K., Pasche, B. (Boris), Fallen, T. (Taya), Karlan, B.Y. (Beth), Eng, C. (Charis), Kurz, R.N., Armel, S. (Susan), Tulman, A. (Anna), Ainsworth, P.J. (Peter), Lemire, E. (Edmond), McLennan, J., Evans, G. (Gareth), Byrski, T. (Tomas), Huzarski, T. (Tomas), Shulman, L. (Lee), Eisen, A. (Andrea), Lubinski, J. (Jan), Gronwald, J. (Jacek), Moller, P. (Pal), Lynch, H. (Henry), Klijn, J.G.M. (Jan), Kim-Sing, C. (Charmaine), Neuhausen, S.L. (Susan), Gilbert, L. (Lucy), Ghadirian, P. (Parviz), Manoukian, S. (Siranoush), Rennert, G. (Gad), Friedman, E. (Eitan), Isaacs, C. (Claudine), Rosen, B. (Barry), Daly, M.J. (Mark), Sun, P. (Ping), Narod, S. (Steven), Olopade, O.I. (Olofunmilayo), Cummings, S. (Shelly), Tung, N. (Nadine), Couch, F.J. (Fergus), Foulkes, W.D. (William), Domchek, S.M. (Susan), Stoppa-Lyonnet, D. (Dominique), Gershoni-Baruch, R. (Ruth), Horsman, D. (David), Saal, H. (Howard), Warner, E. (Ellen), Meschino, W. (Wendy), Offit, K. (Kenneth), Trivedi, A. (Amber), Robson, M. (Mark), Osborne, M. (Michael), Gilchrist, D. (Dawna), Weitzel, J.N. (Jeffrey), McKinnon, W. (Wendy), Wood, M. (Marie), Maugard, C. (Christine), Pasini, B. (Barbara), Wagner, T. (Teresa), Sweet, K., Pasche, B. (Boris), Fallen, T. (Taya), Karlan, B.Y. (Beth), Eng, C. (Charis), Kurz, R.N., Armel, S. (Susan), Tulman, A. (Anna), Ainsworth, P.J. (Peter), Lemire, E. (Edmond), McLennan, J., Evans, G. (Gareth), Byrski, T. (Tomas), Huzarski, T. (Tomas), and Shulman, L. (Lee)
- Abstract
Background: Hormone therapy (HT) is commonly given to women to alleviate the climacteric symptoms associated with menopause. There is concern that this treatment may increase the risk of breast cancer. The potential association of HT and breast cancer risk is of particular interest to women who carry a mutation in BRCA1 because they face a high lifetime risk of breast cancer and because many of these women take HT after undergoing prophylactic surgical oophorectomy at a young age. Methods: We conducted a matched case-control study of 472 postmenopausal women with a BRCA1 mutation to examine whether or not the use of HT is associated with subsequent risk of breast cancer. Breast cancer case patients and control subjects were matched with respect to age, age at menopause, and type of menopause (surgical or natural). Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated with conditional logistic regression. Statistical tests were two-sided. Results: In this group of BRCA1 mutation carriers, the adjusted OR for breast cancer associated with ever use of HT compared with never use was 0.58 (95% CI = 0.35 to 0.96; P =. 03). In analyses by type of HT, an inverse association with breast cancer risk was observed with use of estrogen only (OR = 0.51, 95% CI = 0.27 to 0.98; P =. 04); the association with use of estrogen plus progesterone was not statistically significant (OR = 0.66, 95% CI = 0.34 to 1.27; P =. 21). Conclusion: Among postmenopausal women with a BRCA1 mutation, HT use was not associated with increased risk of breast cancer; indeed, in this population, it was associated with a decreased risk.
- Published
- 2008
- Full Text
- View/download PDF
49. International variation in rates of uptake of preventive options in BRCA1 and BRCA2 mutation carriers
- Author
-
Metcalfe, K.A. (Kelly), Birenbaum-Carmeli, D. (Daphna), Lubinski, J. (Jan), Gronwald, J. (Jacek), Lynch, H. (Henry), Moller, P. (Pal), Ghadirian, P. (Parviz), Foulkes, W.D. (William), Klijn, J.G.M. (Jan), Friedman, E. (Eitan), Kim-Sing, C. (Charmaine), Ainsworth, P.J. (Peter), Rosen, B. (Barry), Domchek, S.M. (Susan), Wagner, T. (Teresa), Tung, N. (Nadine), Manoukian, S. (Siranoush), Couch, F.J. (Fergus), Sun, P. (Ping), Narod, S. (Steven), Daly, M.J. (Mark), Eisen, A. (Andrea), Saal, H.M., Sweet, K., Lyonnet, D. (Dominique), Rennen, G., McLennan, J., Gershoni-Baruch, R., Garber, J., Cummings, S., Weitzel, J.N. (Jeffrey), Karlan, B.Y. (Beth), Kurz, R.N., McKinnon, W., Wood, M., Osborne, M. (Michael), Gilchrist, D., Chudley, A., Fishman, D. (David), Meschino, W.S., Lemire, E., Maugard, C., Mills, G., Merajver, S.D. (Sofia), Rayson, D., Collée, J.M. (Margriet), Metcalfe, K.A. (Kelly), Birenbaum-Carmeli, D. (Daphna), Lubinski, J. (Jan), Gronwald, J. (Jacek), Lynch, H. (Henry), Moller, P. (Pal), Ghadirian, P. (Parviz), Foulkes, W.D. (William), Klijn, J.G.M. (Jan), Friedman, E. (Eitan), Kim-Sing, C. (Charmaine), Ainsworth, P.J. (Peter), Rosen, B. (Barry), Domchek, S.M. (Susan), Wagner, T. (Teresa), Tung, N. (Nadine), Manoukian, S. (Siranoush), Couch, F.J. (Fergus), Sun, P. (Ping), Narod, S. (Steven), Daly, M.J. (Mark), Eisen, A. (Andrea), Saal, H.M., Sweet, K., Lyonnet, D. (Dominique), Rennen, G., McLennan, J., Gershoni-Baruch, R., Garber, J., Cummings, S., Weitzel, J.N. (Jeffrey), Karlan, B.Y. (Beth), Kurz, R.N., McKinnon, W., Wood, M., Osborne, M. (Michael), Gilchrist, D., Chudley, A., Fishman, D. (David), Meschino, W.S., Lemire, E., Maugard, C., Mills, G., Merajver, S.D. (Sofia), Rayson, D., and Collée, J.M. (Margriet)
- Abstract
Several options for cancer prevention are available for women with a BRCA1 or BRCA2 mutation, including prophylactic surgery, chemoprevention and
- Published
- 2008
- Full Text
- View/download PDF
50. Hereditary Colorectal Cancer Registries in Canada: Report from the Colorectal Cancer Association of Canada Consensus Meeting; Montreal, Quebec; October 28, 2011
- Author
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Rothenmund, H., primary, Singh, H., additional, Candas, B., additional, Chodirker, B.N., additional, Serfas, K., additional, Aronson, M., additional, Holter, S., additional, Volenik, A., additional, Green, J., additional, Dicks, E., additional, Woods, M.O., additional, Gilchrist, D., additional, Gryfe, R., additional, Cohen, Z., additional, and Foulkes, W.D., additional
- Published
- 2013
- Full Text
- View/download PDF
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