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1. Obesity II: Establishing causal links between chemical exposures and obesity

Author

Heindel, Jerrold J, Howard, Sarah, Agay-Shay, Keren, Arrebola, Juan P, Audouze, Karine, Babin, Patrick J, Barouki, Robert, Bansal, Amita, Blanc, Etienne, Cave, Matthew C, Chatterjee, Saurabh, Chevalier, Nicolas, Choudhury, Mahua, Collier, David, Connolly, Lisa, Coumoul, Xavier, Garruti, Gabriella, Gilbertson, Michael, Hoepner, Lori A, Holloway, Alison C, Howell, George, Kassotis, Christopher D, Kay, Mathew K, Kim, Min Ji, Lagadic-Gossmann, Dominique, Langouet, Sophie, Legrand, Antoine, Li, Zhuorui, Le Mentec, Helene, Lind, Lars, Lind, P Monica, Lustig, Robert H, Martin-Chouly, Corinne, Kos, Vesna Munic, Podechard, Normand, Roepke, Troy A, Sargis, Robert M, Starling, Anne, Tomlinson, Craig R, Touma, Charbel, Vondracek, Jan, Saal, Frederick vom, and Blumberg, Bruce

Subjects
Genetics, Nutrition, Obesity, Digestive Diseases, Prevention, Oral and gastrointestinal, Metabolic and endocrine, Adipogenesis, Adipose Tissue, Child, Preschool, Endocrine Disruptors, Environmental Exposure, Humans, Obesogen, Adipocyte differentiation, Weight gain, Endocrine disruptor, Biochemistry and Cell Biology, Pharmacology and Pharmaceutical Sciences, Pharmacology & Pharmacy
Abstract

Obesity is a multifactorial disease with both genetic and environmental components. The prevailing view is that obesity results from an imbalance between energy intake and expenditure caused by overeating and insufficient exercise. We describe another environmental element that can alter the balance between energy intake and energy expenditure: obesogens. Obesogens are a subset of environmental chemicals that act as endocrine disruptors affecting metabolic endpoints. The obesogen hypothesis posits that exposure to endocrine disruptors and other chemicals can alter the development and function of the adipose tissue, liver, pancreas, gastrointestinal tract, and brain, thus changing the set point for control of metabolism. Obesogens can determine how much food is needed to maintain homeostasis and thereby increase the susceptibility to obesity. The most sensitive time for obesogen action is in utero and early childhood, in part via epigenetic programming that can be transmitted to future generations. This review explores the evidence supporting the obesogen hypothesis and highlights knowledge gaps that have prevented widespread acceptance as a contributor to the obesity pandemic. Critically, the obesogen hypothesis changes the narrative from curing obesity to preventing obesity.

Published
2022

2. Economic evaluation: immunoglobulin vs prophylactic antibiotics in hypogammaglobulinemia and hematological malignancies

Author

Carrillo de Albornoz, Sara, Higgins, Alisa M., Petrie, Dennis, Irving, Adam, Fanning, Laura, Weinkove, Robert, Crispin, Philip, Dendle, Claire, Gilbertson, Michael, Johnston, Anna, Keegan, Anastazia, Pepperell, Dominic, Pullon, Humphrey, Reynolds, John, van Tonder, Tina, Trotman, Judith, Waters, Neil, Wellard, Cameron, Weston, Helen, Morrissey, C. Orla, Wood, Erica M., and McQuilten, Zoe K.

Published
2024
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3. Immunoglobulin replacement vs prophylactic antibiotics for hypogammaglobulinemia secondary to hematological malignancy

Author

McQuilten, Zoe K., Weinkove, Robert, Thao, Le Thi Phuong, Crispin, Philip, Degelia, Amber, Dendle, Claire, Gilbertson, Michael, Johnston, Anna, Keegan, Anastazia, Pepperell, Dominic, Pullon, Humphrey, Reynolds, John, van Tonder, Tina, Trotman, Judith, Waters, Neil, Wellard, Cameron, Weston, Helen, Morrissey, C. Orla, and Wood, Erica M.

Published
2024
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5. The beautiful & the good (after Beethoven)

Author

Gilbertson, Michael and Gilbertson, Michael

Subjects
Orchestral music Scores., Orchestre, Musique d' Partitions., Orchestral music Scores.
Abstract

This music score was submitted for the Kaleidoscope 2020 Call for Scores, an open access collaboration with the UCLA Music Library.

Published
2024

6. The Beautiful & The Good

Author

Gilbertson, Michael

Abstract

This music score was submitted for the Kaleidoscope 2020 Call for Scores, an open access collaboration with the UCLA Music Library.

Published
2020

7. Mother Chords

Author

Gilbertson, Michael

Abstract

This music score was submitted for the Kaleidoscope 2020 Call for Scores, an open access collaboration with the UCLA Music Library.

Published
2020

9. Obesity II: Establishing causal links between chemical exposures and obesity

Author

Heindel, Jerrold J., Howard, Sarah, Agay-Shay, Keren, Arrebola, Juan P., Audouze, Karine, Babin, Patrick J., Barouki, Robert, Bansal, Amita, Blanc, Etienne, Cave, Matthew C., Chatterjee, Saurabh, Chevalier, Nicolas, Choudhury, Mahua, Collier, David, Connolly, Lisa, Coumoul, Xavier, Garruti, Gabriella, Gilbertson, Michael, Hoepner, Lori A., Holloway, Alison C., Howell, George, III, Kassotis, Christopher D., Kay, Mathew K., Kim, Min Ji, Lagadic-Gossmann, Dominique, Langouet, Sophie, Legrand, Antoine, Li, Zhuorui, Le Mentec, Helene, Lind, Lars, Monica Lind, P., Lustig, Robert H., Martin-Chouly, Corinne, Munic Kos, Vesna, Podechard, Normand, Roepke, Troy A., Sargis, Robert M., Starling, Anne, Tomlinson, Craig R., Touma, Charbel, Vondracek, Jan, vom Saal, Frederick, and Blumberg, Bruce

Published
2022
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10. Obesity I: Overview and molecular and biochemical mechanisms

Author

Lustig, Robert H., Collier, David, Kassotis, Christopher, Roepke, Troy A., Kim, Min Ji, Blanc, Etienne, Barouki, Robert, Bansal, Amita, Cave, Matthew C., Chatterjee, Saurabh, Choudhury, Mahua, Gilbertson, Michael, Lagadic-Gossmann, Dominique, Howard, Sarah, Lind, Lars, Tomlinson, Craig R., Vondracek, Jan, and Heindel, Jerrold J.

Published
2022
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11. Sequential high‐dose methotrexate and cytarabine administration improves outcomes in real‐world patients with primary central nervous system lymphoma: A report from the Australasian Lymphoma Alliance.

Author

Tatarczuch, Maciej, Lewis, Katharine Louise, Gunjur, Ashray, Shaw, Briony, Poon, Li Mei, Paul, Erin, Ku, Matthew, Wong, Mark, Ai, Sylvia, Beekman, Ashley, Ciaccio, Pietro R. Di, Krigstein, Michael, Wight, Joel, Coombes, Caitlin, Gilbertson, Michael, Tey, Amanda, Shortt, Jake, Nagarajan, Chandramouli, Talaulikar, Dipti, and Hamad, Nada

Published
2024
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13. Designing a broad-spectrum integrative approach for cancer prevention and treatment

Author

Block, Keith I, Gyllenhaal, Charlotte, Lowe, Leroy, Amedei, Amedeo, Amin, ARM Ruhul, Amin, Amr, Aquilano, Katia, Arbiser, Jack, Arreola, Alexandra, Arzumanyan, Alla, Ashraf, S Salman, Azmi, Asfar S, Benencia, Fabian, Bhakta, Dipita, Bilsland, Alan, Bishayee, Anupam, Blain, Stacy W, Block, Penny B, Boosani, Chandra S, Carey, Thomas E, Carnero, Amancio, Carotenuto, Marianeve, Casey, Stephanie C, Chakrabarti, Mrinmay, Chaturvedi, Rupesh, Chen, Georgia Zhuo, Chen, Helen, Chen, Sophie, Chen, Yi Charlie, Choi, Beom K, Ciriolo, Maria Rosa, Coley, Helen M, Collins, Andrew R, Connell, Marisa, Crawford, Sarah, Curran, Colleen S, Dabrosin, Charlotta, Damia, Giovanna, Dasgupta, Santanu, DeBerardinis, Ralph J, Decker, William K, Dhawan, Punita, Diehl, Anna Mae E, Dong, Jin-Tang, Dou, Q Ping, Drew, Janice E, Elkord, Eyad, El-Rayes, Bassel, Feitelson, Mark A, Felsher, Dean W, Ferguson, Lynnette R, Fimognari, Carmela, Firestone, Gary L, Frezza, Christian, Fujii, Hiromasa, Fuster, Mark M, Generali, Daniele, Georgakilas, Alexandros G, Gieseler, Frank, Gilbertson, Michael, Green, Michelle F, Grue, Brendan, Guha, Gunjan, Halicka, Dorota, Helferich, William G, Heneberg, Petr, Hentosh, Patricia, Hirschey, Matthew D, Hofseth, Lorne J, Holcombe, Randall F, Honoki, Kanya, Hsu, Hsue-Yin, Huang, Gloria S, Jensen, Lasse D, Jiang, Wen G, Jones, Lee W, Karpowicz, Phillip A, Keith, W Nicol, Kerkar, Sid P, Khan, Gazala N, Khatami, Mahin, Ko, Young H, Kucuk, Omer, Kulathinal, Rob J, Kumar, Nagi B, Kwon, Byoung S, Le, Anne, Lea, Michael A, Lee, Ho-Young, Lichtor, Terry, Lin, Liang-Tzung, Locasale, Jason W, Lokeshwar, Bal L, Longo, Valter D, Lyssiotis, Costas A, MacKenzie, Karen L, Malhotra, Meenakshi, Marino, Maria, Martinez-Chantar, Maria L, and Matheu, Ander

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, Rare Diseases, Precision Medicine, 2.1 Biological and endogenous factors, 5.1 Pharmaceuticals, Good Health and Well Being, Antineoplastic Agents, Phytogenic, Drug Resistance, Neoplasm, Genetic Heterogeneity, Humans, Molecular Targeted Therapy, Neoplasms, Signal Transduction, Tumor Microenvironment, Multi-targeted, Cancer hallmarks, Phytochemicals, Targeted therapy, Integrative medicine, Oncology & Carcinogenesis, Biochemistry and cell biology, Oncology and carcinogenesis
Abstract

Targeted therapies and the consequent adoption of "personalized" oncology have achieved notable successes in some cancers; however, significant problems remain with this approach. Many targeted therapies are highly toxic, costs are extremely high, and most patients experience relapse after a few disease-free months. Relapses arise from genetic heterogeneity in tumors, which harbor therapy-resistant immortalized cells that have adopted alternate and compensatory pathways (i.e., pathways that are not reliant upon the same mechanisms as those which have been targeted). To address these limitations, an international task force of 180 scientists was assembled to explore the concept of a low-toxicity "broad-spectrum" therapeutic approach that could simultaneously target many key pathways and mechanisms. Using cancer hallmark phenotypes and the tumor microenvironment to account for the various aspects of relevant cancer biology, interdisciplinary teams reviewed each hallmark area and nominated a wide range of high-priority targets (74 in total) that could be modified to improve patient outcomes. For these targets, corresponding low-toxicity therapeutic approaches were then suggested, many of which were phytochemicals. Proposed actions on each target and all of the approaches were further reviewed for known effects on other hallmark areas and the tumor microenvironment. Potential contrary or procarcinogenic effects were found for 3.9% of the relationships between targets and hallmarks, and mixed evidence of complementary and contrary relationships was found for 7.1%. Approximately 67% of the relationships revealed potentially complementary effects, and the remainder had no known relationship. Among the approaches, 1.1% had contrary, 2.8% had mixed and 62.1% had complementary relationships. These results suggest that a broad-spectrum approach should be feasible from a safety standpoint. This novel approach has potential to be relatively inexpensive, it should help us address stages and types of cancer that lack conventional treatment, and it may reduce relapse risks. A proposed agenda for future research is offered.

Published
2015

14. Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead

Author

Goodson, William H, Lowe, Leroy, Carpenter, David O, Gilbertson, Michael, Manaf Ali, Abdul, Lopez de Cerain Salsamendi, Adela, Lasfar, Ahmed, Carnero, Amancio, Azqueta, Amaya, Amedei, Amedeo, Charles, Amelia K, Collins, Andrew R, Ward, Andrew, Salzberg, Anna C, Colacci, Annamaria, Olsen, Ann-Karin, Berg, Arthur, Barclay, Barry J, Zhou, Binhua P, Blanco-Aparicio, Carmen, Baglole, Carolyn J, Dong, Chenfang, Mondello, Chiara, Hsu, Chia-Wen, Naus, Christian C, Yedjou, Clement, Curran, Colleen S, Laird, Dale W, Koch, Daniel C, Carlin, Danielle J, Felsher, Dean W, Roy, Debasish, Brown, Dustin G, Ratovitski, Edward, Ryan, Elizabeth P, Corsini, Emanuela, Rojas, Emilio, Moon, Eun-Yi, Laconi, Ezio, Marongiu, Fabio, Al-Mulla, Fahd, Chiaradonna, Ferdinando, Darroudi, Firouz, Martin, Francis L, Van Schooten, Frederik J, Goldberg, Gary S, Wagemaker, Gerard, Nangami, Gladys N, Calaf, Gloria M, Williams, Graeme, Wolf, Gregory T, Koppen, Gudrun, Brunborg, Gunnar, Lyerly, H Kim, Krishnan, Harini, Ab Hamid, Hasiah, Yasaei, Hemad, Sone, Hideko, Kondoh, Hiroshi, Salem, Hosni K, Hsu, Hsue-Yin, Park, Hyun Ho, Koturbash, Igor, Miousse, Isabelle R, Scovassi, A Ivana, Klaunig, James E, Vondráček, Jan, Raju, Jayadev, Roman, Jesse, Wise, John Pierce, Whitfield, Jonathan R, Woodrick, Jordan, Christopher, Joseph A, Ochieng, Josiah, Martinez-Leal, Juan Fernando, Weisz, Judith, Kravchenko, Julia, Sun, Jun, Prudhomme, Kalan R, Narayanan, Kannan Badri, Cohen-Solal, Karine A, Moorwood, Kim, Gonzalez, Laetitia, Soucek, Laura, Jian, Le, D'Abronzo, Leandro S, Lin, Liang-Tzung, Li, Lin, Gulliver, Linda, McCawley, Lisa J, Memeo, Lorenzo, Vermeulen, Louis, Leyns, Luc, Zhang, Luoping, Valverde, Mahara, Khatami, Mahin, Romano, Maria Fiammetta, Chapellier, Marion, Williams, Marc A, and Wade, Mark

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, 2.2 Factors relating to the physical environment, Animals, Carcinogenesis, Carcinogens, Environmental, Environmental Exposure, Hazardous Substances, Humans, Neoplasms, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers attributable to toxic environmental exposures is between 7% and 19%. To explore the hypothesis that low-dose exposures to mixtures of chemicals in the environment may be combining to contribute to environmental carcinogenesis, we reviewed 11 hallmark phenotypes of cancer, multiple priority target sites for disruption in each area and prototypical chemical disruptors for all targets, this included dose-response characterizations, evidence of low-dose effects and cross-hallmark effects for all targets and chemicals. In total, 85 examples of chemicals were reviewed for actions on key pathways/mechanisms related to carcinogenesis. Only 15% (13/85) were found to have evidence of a dose-response threshold, whereas 59% (50/85) exerted low-dose effects. No dose-response information was found for the remaining 26% (22/85). Our analysis suggests that the cumulative effects of individual (non-carcinogenic) chemicals acting on different pathways, and a variety of related systems, organs, tissues and cells could plausibly conspire to produce carcinogenic synergies. Additional basic research on carcinogenesis and research focused on low-dose effects of chemical mixtures needs to be rigorously pursued before the merits of this hypothesis can be further advanced. However, the structure of the World Health Organization International Programme on Chemical Safety 'Mode of Action' framework should be revisited as it has inherent weaknesses that are not fully aligned with our current understanding of cancer biology.

Published
2015

16. Outcomes of stage I/II follicular lymphoma in the PET era: an international study from the Australian Lymphoma Alliance

Author

Tobin, Joshua W.D., Rule, Gabrielle, Colvin, Katherine, Calvente, Lourdes, Hodgson, David, Bell, Stephen, Dunduru, Chengetai, Gallo, James, Tsang, Erica S., Tan, Xuan, Wong, Jonathan, Pearce, Jessica, Campbell, Robert, Tneh, Shao, Shorten, Sophie, Ng, Melissa, Cochrane, Tara, Tam, Constantine S., Abro, Emad, Hawkes, Eliza, Hodges, Georgina, Kansara, Roopesh, Talaulikar, Dipti, Gilbertson, Michael, Johnston, Anna M., Savage, Kerry J., Villa, Diego, Morris, Kirk, Ratnasingam, Sumi, Janowski, Wojt, Kridel, Robert, Cheah, Chan Y., MacManus, Michael, Matigian, Nicholas, Mollee, Peter, Gandhi, Maher K., and Hapgood, Greg

Published
2019
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17. Treatment strategies, outcomes and prognostic factors in 291 patients with secondary CNS involvement by diffuse large B-cell lymphoma

Author

El-Galaly, Tarec Christoffer, Cheah, Chan Yoon, Bendtsen, Mette Dahl, Nowakowski, Grzegorz S., Kansara, Roopesh, Savage, Kerry J., Connors, Joseph M., Sehn, Laurie H., Goldschmidt, Neta, Shaulov, Adir, Farooq, Umar, Link, Brian K., Ferreri, Andrés J.M., Calimeri, Teresa, Cecchetti, Caterina, Dann, Eldad J., Thompson, Carrie A., Inbar, Tsofia, Maurer, Matthew J., Gade, Inger Lise, Juul, Maja Bech, Hansen, Jakob W., Holmberg, Staffan, Larsen, Thomas S., Cordua, Sabrina, Mikhaeel, N. George, Hutchings, Martin, Seymour, John F., Clausen, Michael Roost, Smith, Daniel, Opat, Stephen, Gilbertson, Michael, Thanarajasingam, Gita, and Villa, Diego

Published
2018
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19. Injury to health : a forensic audit of the Great Lakes Water Quality Agreement (1972-2005) with special reference to congenital Minamata disease

Author

Gilbertson, Michael and Watterson, Andrew

Subjects
333, Mercury Toxicology, Water quality Great Lakes (North America), Great Lakes (North America)
Abstract

The objective of this research was to examine whether the United States and Canada have successfully implemented their Great Lakes Water Quality Agreement and to identify the factors determining the continuation of any injury to human health from pollution of the boundary waters. The Agreement was first negotiated in 1972 as part of the legitimation of the social unrest of the 1960s and gave special responsibilities to the International Joint Commission to advise the Parties of problems of water quality. It has been subject to periodic review and occasional renegotiation and amendment. Specifically, the Agreement was renegotiated in 1978 to address the health effects from the imperceptible exposures to persistent toxic substances. Though extensive scientific evidence of continuing injury to health from persistent toxic substances has been available, there has been a consistent pattern of deliberate failure by the authorities to report the injury and to implement many of the remedial provisions contained in the Agreement. The thesis claims that the failure of the International Joint Commission to advise the Parties of the new information about the injury to health and the failure of the Parties to act upon the information when it was obtained from other sources constituted dereliction of duty. While synthesis of the science linking the pollutant-induced injury to specific causal agents was necessary to provide an empirical measure of the failure to implement the Agreement, consideration of the social, economic and political aspects was needed to provide a sufficient explanation for the failure of the International Joint Commission to inform and of the authorities to act. There have been active attempts to use diversionary reframing of the Agreement, based on a multi-causal ecosystem theory proposed by fisheries ecologists, to attenuate the risk message and transform the Great Lakes Water Quality Agreement into a more inclusive and less focused agreement on restoring ecosystem integrity. This has been welcomed by industry and governments as a means to remove the focus from addressing the unresolved dangers of persistent toxic substances through costly remedial actions. The International Joint Commission undermined its credibility when it recommended ‘sunsetting’ the use of chlorine in chemical manufacturing. The Parties failed to use a precautionary approach to prevent the commercial introduction of new persistent toxic substances, such as the brominated flame retardants. Since the 1980s, the economic politics of the two nations have been profoundly influenced by neo-liberalism and one of the consequences has been the removal of environmental health as a priority from the respective political agenda. Advisory bodies seem to have been captured not only by the prevailing neo-liberalism but also by corporate interests and these factors seem to underlie the reluctance to report the injury to health from exposures to persistent toxic substances. Though there were many different health endpoints affected by exposures to water pollutants in the Great Lakes, the thesis concentrated on the evidence of neuro-teratogenic effects. The adequacy of the implementation of the Agreement during the past thirty-three years was tested by using Health Canada data on cerebral palsy hospitalisation to evaluate whether there were indications of previously undetected outbreaks of congenital Minamata disease in human populations in Canadian Great Lakes communities potentially exposed to methyl mercury from natural sources or from historic industrial uses of mercury. The uncertainties in the apparent association that was found were reduced by the application of Hill’s guidelines. While these findings indicated both the need for further multi-disciplinary research to locate and diagnose the victims and for a precautionary approach to the consumption of Great Lakes fish, they also indicated that, for more than three decades, health authorities have not diligently implemented the Agreement. The inclusion of the social, economic and political considerations in the forensic audit has revealed the dangers inherent in any renegotiation of the Great Lakes Water Quality Agreement.

Published
2006

20. P1230: T CELL CD62L EXPRESSION FOLLOWING NIVOLUMAB THERAPY IS ASSOCIATED WITH LONG TERM RESPONSE TO RITUXIMAB-NIVOLUMAB IN TREATMENT NAÏVE FOLLICULAR LYMPHOMA: RESULTS FROM THE 1ST FLOR STUDY

Author

Koldej, Rachel, primary, Barraclough, Allison, additional, Ting Lee, Sze, additional, Morgan, Huw, additional, Holzwart, Nicholas, additional, Koshy, Minu, additional, Smith, Charmaine, additional, Chong, Geoff, additional, Gilbertson, Michael, additional, Keane, Colm, additional, Ting, Stephen, additional, Churilov, Leonid, additional, Ritchie, David, additional, and Hawkes, Eliza A., additional

Published
2023
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35. Outcomes of human immunodeficiency virus‐associated Burkitt lymphoma and diffuse large B‐cell lymphoma treated in Australia: A report from the Australasian Lymphoma Alliance

Author

Lim, Kenneth J. C., primary, Di Ciaccio, Pietro, additional, Polizzotto, Mark N., additional, Milliken, Sam, additional, Cochrane, Tara, additional, Goh, Zhong, additional, Shaw, Briony, additional, Perry, Evelyn, additional, Gilbertson, Michael, additional, Kermode, William, additional, Cheah, Chan Y., additional, Latimer, Maya, additional, Hamad, Nada, additional, and Ku, Matthew, additional

Published
2023
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36. Outcomes in grade 3B follicular lymphoma: an international study led by the Australasian Lymphoma Alliance

Author

Barraclough, Allison, primary, England, James T., additional, Villa, Diego, additional, Wight, Joel, additional, Hapgood, Greg, additional, Conn, Jason, additional, Doo, Nicole Wong, additional, Li, Eric Wenlong, additional, Gilbertson, Michael, additional, Shaw, Briony, additional, Bishton, Mark J., additional, Saeed, Malik, additional, Ratnasingam, Sumita, additional, Abeyakoon, Chathuri, additional, Chong, Geoff, additional, Wai, Shin Hnin, additional, Ku, Matthew, additional, Lee, Hui-Peng, additional, Fleming, Kathryn, additional, Tam, Constantine, additional, Douglas, Genevieve, additional, Cheah, Chan Y., additional, Ng, Zi Yun, additional, Rolfe, Tukten, additional, Mills, Anthony K, additional, Hamad, Nada, additional, Cashman, Helen, additional, Gleeson, Mary, additional, Narayana, Manjunath, additional, and Hawkes, Eliza A., additional

Published
2023
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37. International Prognostic Score for Nodular Lymphocyte-Predominant Hodgkin Lymphoma

Author

Binkley, Michael S., primary, Flerlage, Jamie E., additional, Borchmann, Peter, additional, Fuchs, Michael, additional, Hartmann, Sylvia, additional, Eich, Hans Theodor, additional, Savage, Kerry J., additional, Lo, Andrea C., additional, Skinnider, Brian, additional, Akhtar, Saad, additional, Rauf, M. Shahzad, additional, Maghfoor, Irfan, additional, Pinnix, Chelsea, additional, Steiner, Raphael, additional, Milgrom, Sarah A., additional, Vega, Francisco, additional, Alomari, Mohammed, additional, Yang, Xiao-Yin, additional, Collins, Graham, additional, Advani, Ranjana H., additional, Metzger, Monika, additional, Dickinson, Michael, additional, Wirth, Andrew, additional, Tsang, Richard, additional, Prica, Anca, additional, Major, Ajay, additional, Smith, Sonali, additional, Hendrickson, Peter G., additional, Kelsey, Chris R., additional, Hopkins, David, additional, McKay, Pam, additional, Ng, Andrea, additional, Koenig, Julie, additional, Constine, Louis S., additional, Casulo, Carla, additional, Sakthivel, Gukan, additional, Baron, Jonathan, additional, Plastaras, John P., additional, Roberts, Kenneth B., additional, Gao, Sarah, additional, Al Kendi, Jalila, additional, Al Rahbi, Nasser, additional, Balogh, Alex, additional, Levis, Mario, additional, Ricardi, Umberto, additional, Sridhar, Akshay, additional, Torka, Pallawi, additional, Specht, Lena, additional, De Silva, Ravindu, additional, Shah, Nimish, additional, Pickard, Keir, additional, Osborne, Wendy, additional, Blazin, Lindsay J., additional, Henry, Michael, additional, Chang, Isabela, additional, Smith, Christine M., additional, Halperin, Daniel, additional, Miall, Fiona, additional, Brady, Jessica, additional, Mikhaeel, George, additional, Brennan, Bernadette, additional, Penn, Anthony, additional, Senchenko, Mariia Anatolevna, additional, Volchkov, Egor Vasilevich, additional, Reeves, Marie, additional, Hoppe, Bradford S., additional, Terezakis, Stephanie, additional, Talaulikar, Dipti, additional, Della Pepa, Roberta, additional, Picardi, Marco, additional, Kirova, Youlia, additional, Fergusson, Paige, additional, Northend, Michael, additional, Hawkes, Eliza, additional, Lee, Denise, additional, Wong Doo, Nicole, additional, Barraclough, Allison, additional, Opat, Stephen, additional, Cheah, Chan, additional, Salvaris, Ross, additional, Ku, Matthew, additional, Hamad, Nada, additional, Mutsando, Howard, additional, Tedjaseputra, Aditya, additional, Gilbertson, Michael, additional, Marconi, Tamara, additional, Viiala, Nicholas, additional, Palese, Monica, additional, Shankar, Ananth, additional, Maurer, Matthew J., additional, Natkunam, Yasodha, additional, Kelly, Kara M., additional, Eichenauer, Dennis A., additional, and Hoppe, Richard T., additional

Published
2023
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41. Corrigendum to “Obesity II: Establishing causal links between chemical exposures and obesity” [Biochem. Pharmacol. 199 (2022) 115015]

Author

Heindel, Jerrold J., primary, Howard, Sarah, additional, Agay-Shay, Keren, additional, Arrebola, Juan P., additional, Audouze, Karine, additional, Babin, Patrick J., additional, Barouki, Robert, additional, Bansal, Amita, additional, Blanc, Etienne, additional, Cave, Matthew C., additional, Chatterjee, Saurabh, additional, Chevalier, Nicolas, additional, Choudhury, Mahua, additional, Collier, David, additional, Connolly, Lisa, additional, Coumoul, Xavier, additional, Garruti, Gabriella, additional, Gilbertson, Michael, additional, Hoepner, Lori A., additional, Holloway, Alison C., additional, Howell, George, additional, Kassotis, Christopher D., additional, Kay, Mathew K., additional, Kim, Min Ji, additional, Lagadic-Gossmann, Dominique, additional, Langouet, Sophie, additional, Legrand, Antoine, additional, Li, Zhuorui, additional, Le Mentec, Helene, additional, Lind, Lars, additional, Lind, P. Monica, additional, Lustig, Robert H., additional, Martin-Chouly, Corinne, additional, Munic Kos, Vesna, additional, Podechard, Normand, additional, Roepke, Troy A., additional, Sargis, Robert M., additional, Starling, Anne, additional, Tomlinson, Craig R., additional, Touma, Charbel, additional, Vondracek, Jan, additional, vom Saal, Frederick, additional, and Blumberg, Bruce, additional

Published
2022
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44. Recommendation for TP53 mutation testing in newly diagnosed mantle cell lymphoma: a statement from working groups sponsored by the Victorian Comprehensive Cancer Centre

Author

Tam, Constantine S., primary, Gregory, Gareth P., additional, Ku, Matthew, additional, Fleming, Shaun, additional, Handunnetti, Sasanka M., additional, Lee, Denise, additional, Walker, Patricia, additional, Perkins, Andrew, additional, Lew, Thomas E., additional, Sirdesai, Shreerang, additional, Chua, Chong Chyn, additional, Gilbertson, Michael, additional, Lasica, Masa, additional, Anderson, Mary Ann, additional, Renwick, William, additional, Grigg, Andrew, additional, Patil, Sush, additional, Opat, Stephen, additional, Friebe, Adam, additional, Cooke, Rachel, additional, De Boer, Jasper, additional, Spencer, Andrew, additional, Ritchie, David, additional, Agarwal, Rishu, additional, and Blombery, Piers, additional

Published
2022
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47. Obesity II : Establishing causal links between chemical exposures and obesity (vol 199, 115015, 2022)

Author

Heindel, Jerrold J., Howard, Sarah, Agay-Shay, Keren, Arrebola, Juan P., Audouze, Karine, Babin, Patrick J., Barouki, Robert, Bansal, Amita, Blanc, Etienne, Cave, Matthew C., Chatterjee, Saurabh, Chevalier, Nicolas, Choudhury, Mahua, Collier, David, Connolly, Lisa, Coumoul, Xavier, Garruti, Gabriella, Gilbertson, Michael, Hoepner, Lori A., Holloway, Alison C., Howell, George, III, Kassotis, Christopher D., Kay, Mathew K., Kim, Min Ji, Lagadic-Gossmann, Dominique, Langouet, Sophie, Legrand, Antoine, Li, Zhuorui, Le Mentec, Helene, Lind, Lars, Lind, P. Monica, Lustig, Robert H., Martin-Chouly, Corinne, Kos, Vesna Munic, Podechard, Normand, Roepke, Troy A., Sargis, Robert M., Starling, Anne, Tomlinson, Craig R., Touma, Charbel, Vondracek, Jan, vom Saal, Frederick, Blumberg, Bruce, Heindel, Jerrold J., Howard, Sarah, Agay-Shay, Keren, Arrebola, Juan P., Audouze, Karine, Babin, Patrick J., Barouki, Robert, Bansal, Amita, Blanc, Etienne, Cave, Matthew C., Chatterjee, Saurabh, Chevalier, Nicolas, Choudhury, Mahua, Collier, David, Connolly, Lisa, Coumoul, Xavier, Garruti, Gabriella, Gilbertson, Michael, Hoepner, Lori A., Holloway, Alison C., Howell, George, III, Kassotis, Christopher D., Kay, Mathew K., Kim, Min Ji, Lagadic-Gossmann, Dominique, Langouet, Sophie, Legrand, Antoine, Li, Zhuorui, Le Mentec, Helene, Lind, Lars, Lind, P. Monica, Lustig, Robert H., Martin-Chouly, Corinne, Kos, Vesna Munic, Podechard, Normand, Roepke, Troy A., Sargis, Robert M., Starling, Anne, Tomlinson, Craig R., Touma, Charbel, Vondracek, Jan, vom Saal, Frederick, and Blumberg, Bruce

Published
2022
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50. PD23 Economic Evaluation Of Prophylactic Immunoglobulin Versus Prophylactic Antibiotics In Hematological Malignancies: Results From The RATIONAL Feasibility Trial.

Author

De Albornoz, Sara Carrillo, Higgins, Alisa, Petrie, Dennis, Irving, Adam, Fanning, Laura, Weinkove, Robert, Crispin, Philip, Dendle, Claire, Gilbertson, Michael, Johnston, Anna, Keegan, Anastazia, Pepperell, Dominic, Pullon, Humphrey, Reynolds, John, Tonder, Tina van, Trotman, Judith, Waters, Neil, Wellard, Cameron, Weston, Helen, and Morrissey, Orla

Abstract

Introduction: Patients with hematological malignancies are at high risk of infections due to both the disease and the associated treatments. The use of immunoglobulin (Ig) to prevent infections is increasing in this population, but its cost effectiveness is unknown. This trial-based economic evaluation aimed to compare the cost effectiveness of prophylactic Ig with prophylactic antibiotics in patients with hematological malignancies. Methods: The economic evaluation used individual patient data from the RATIONAL feasibility trial, which randomly assigned 63 adults with chronic lymphocytic leukemia, multiple myeloma, or lymphoma to prophylactic Ig or prophylactic antibiotics. The following two analyses were conducted to estimate the cost effectiveness of the two treatments over the 12-month trial period from the perspective of the Australian health system: (i) a cost-utility analysis (CUA) to assess the incremental cost per quality-adjusted life-year (QALY) gained using data collected with the EuroQol 5D-5L questionnaire; and (ii) a cost-effectiveness analysis (CEA) to assess the incremental cost per serious infection prevented (grade ≥3) and per infection prevented (any grade). Results: The total cost per patient was significantly higher in the Ig arm than in the antibiotic arm (difference AUD29,140 [USD19,000]). There were non-significant differences in health outcomes between the treatment arms: patients treated with Ig had fewer QALYs (difference −0.072) and serious infections (difference −0.26) than those given antibiotics, but more overall infections (difference 0.76). The incremental cost-effectiveness from the CUA indicated that Ig was more costly than antibiotics and associated with fewer QALYs. In the CEA, Ig costed an additional AUD111,262 (USD73,000) per serious infection prevented, but it was more costly than antibiotics and associated with more infections when all infections were included. Conclusions: These results indicate that, on average, Ig prophylactic treatment may not be cost effective compared with prophylactic antibiotics for the group of patients with hematological malignancies recruited to the RATIONAL feasibility trial. Further research is needed to confirm these findings in a larger population and over the longer term. [ABSTRACT FROM AUTHOR]

Published
2025
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