1. Downstream Paclitaxel Released Following Drug-Coated Balloon Inflation and Distal Limb Wound Healing in Swine
- Author
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Juan F. Granada, MD, Marco Ferrone, MD, Gilberto Melnick, MD, Lesley Crookall, BMLSc, Daniel Schulz-Jander, PhD, Stefan Tunev, DVM, Robert J. Melder, DSc, and Grzegorz L. Kaluza, MD, PhD
- Subjects
histopathology ,paclitaxel-coated balloon ,swine ,translational ,wound healing ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Summary: The authors evaluated the presence of paclitaxel and healing of distal hind limb wounds created in 27 swine using biopsy punches followed by paclitaxel-coated balloon (PCB) use in the iliofemoral arteries of healthy swine. After 14 and 28 days, no differences were seen in time course, appearance, and histopathology of wound healing between the single or triple PCB and uncoated balloon treatment despite clinically relevant paclitaxel concentrations in the skin adjacent to the healing wounds. Presence of paclitaxel downstream from the PCB treatment site does not impair the wound healing response of preexisting distal cutaneous lesions in healthy swine.
- Published
- 2021
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