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1. Associations between alcohol use and sex-specific maturation of subcortical gray matter morphometry from adolescence to adulthood: Replication across two longitudinal samples

Author

Jones, Scott A, Morales, Angelica M, Harman, Gareth, Dominguez-Savage, Kalene A, Gilbert, Sydney, Baker, Fiona C, de Zambotti, Massimiliano, Goldston, David B, Nooner, Kate B, Clark, Duncan B, Luna, Beatriz, Thompson, Wesley K, Brown, Sandra A, Tapert, Susan F, and Nagel, Bonnie J

Subjects
Biological Psychology, Biomedical and Clinical Sciences, Paediatrics, Psychology, Substance Misuse, Alcoholism, Alcohol Use and Health, Brain Disorders, Mental Health, Behavioral and Social Science, Underage Drinking, Neurosciences, Clinical Research, Women's Health, Pediatric, 2.1 Biological and endogenous factors, Good Health and Well Being, Humans, Male, Adolescent, Female, Young Adult, Adult, Gray Matter, Cross-Sectional Studies, Magnetic Resonance Imaging, Brain, Thalamus, MRI, Sex differences, Adolescence, Alcohol, Longitudinal, Replication, Clinical Sciences, Cognitive Sciences, Biological psychology, Clinical and health psychology
Abstract

Subcortical brain morphometry matures across adolescence and young adulthood, a time when many youth engage in escalating levels of alcohol use. Initial cross-sectional studies have shown alcohol use is associated with altered subcortical morphometry. However, longitudinal evidence of sex-specific neuromaturation and associations with alcohol use remains limited. This project used generalized additive mixed models to examine sex-specific development of subcortical volumes and associations with recent alcohol use, using 7 longitudinal waves (n = 804, 51% female, ages 12-21 at baseline) from the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA). A second, independent, longitudinal dataset, with up to four waves of data (n = 467, 43% female, ages 10-18 at baseline), was used to assess replicability. Significant, replicable non-linear normative volumetric changes with age were evident in the caudate, putamen, thalamus, pallidum, amygdala and hippocampus. Significant, replicable negative associations between subcortical volume and alcohol use were found in the hippocampus in all youth, and the caudate and thalamus in female but not male youth, with significant interactions present in the caudate, thalamus and putamen. Findings suggest a structural vulnerability to alcohol use, or a predisposition to drink alcohol based on brain structure, with female youth potentially showing heightened risk, compared to male youth.

Published
2023

2. Associations between alcohol use and sex-specific maturation of subcortical gray matter morphometry from adolescence to adulthood: Replication across two longitudinal samples

Author

Jones, Scott A., Morales, Angelica M., Harman, Gareth, Dominguez-Savage, Kalene A., Gilbert, Sydney, Baker, Fiona C., de Zambotti, Massimiliano, Goldston, David B., Nooner, Kate B., Clark, Duncan B., Luna, Beatriz, Thompson, Wesley K., Brown, Sandra A., Tapert, Susan F., and Nagel, Bonnie J.

Published
2023
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4. Associations between alcohol use and sex-specific maturation of subcortical gray matter morphometry from adolescence to adulthood: Replication across two longitudinal samples.

Author

Jones, Scott, Jones, Scott, Morales, Angelica, Harman, Gareth, Dominguez-Savage, Kalene, Gilbert, Sydney, Baker, Fiona, de Zambotti, Massimiliano, Goldston, David, Nooner, Kate, Clark, Duncan, Luna, Beatriz, Brown, Sandra, Nagel, Bonnie, Tapert, Susan, Thompson, Wesley, Jones, Scott, Jones, Scott, Morales, Angelica, Harman, Gareth, Dominguez-Savage, Kalene, Gilbert, Sydney, Baker, Fiona, de Zambotti, Massimiliano, Goldston, David, Nooner, Kate, Clark, Duncan, Luna, Beatriz, Brown, Sandra, Nagel, Bonnie, Tapert, Susan, and Thompson, Wesley

Abstract

Subcortical brain morphometry matures across adolescence and young adulthood, a time when many youth engage in escalating levels of alcohol use. Initial cross-sectional studies have shown alcohol use is associated with altered subcortical morphometry. However, longitudinal evidence of sex-specific neuromaturation and associations with alcohol use remains limited. This project used generalized additive mixed models to examine sex-specific development of subcortical volumes and associations with recent alcohol use, using 7 longitudinal waves (n = 804, 51% female, ages 12-21 at baseline) from the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA). A second, independent, longitudinal dataset, with up to four waves of data (n = 467, 43% female, ages 10-18 at baseline), was used to assess replicability. Significant, replicable non-linear normative volumetric changes with age were evident in the caudate, putamen, thalamus, pallidum, amygdala and hippocampus. Significant, replicable negative associations between subcortical volume and alcohol use were found in the hippocampus in all youth, and the caudate and thalamus in female but not male youth, with significant interactions present in the caudate, thalamus and putamen. Findings suggest a structural vulnerability to alcohol use, or a predisposition to drink alcohol based on brain structure, with female youth potentially showing heightened risk, compared to male youth.

Published
2023

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