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Bullous syndromes in the newborn are not common except in epidemics of impetigo contagiosa (pemphigus neonatorum). The latter is comparatively easy to diagnose, and the usual therapy is successful. Proper prophylactic measures are immediately instituted once the diagnosis is made. The other bullous entities are rare and at times difficult to diagnose immediately, except in the congenital syphilids. A recent opportunity was afforded to study a case of congenital bullous eruption from birth to death. This was the third baby in the family with a bullous eruption and fatal outcome. A clinical diagnosis of epidermolysis bullosa was finally made. The histologic picture was considered by two dermatologists to be diagnostic of the syndrome and by a third with similarly large experience as a bullous syndrome that was compatible with this diagnosis but not diagnostic of it and possibly fitting in with a congenital ectodermal defect.REPORT OF CASEM. F.