203 results on '"Gilbert, Adam M."'
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2. Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes
3. A kinetic proofreading model for bispecific protein degraders
4. Delineating the role of cooperativity in the design of potent PROTACs for BTK
5. Inducing protein-protein interactions with molecular glues
6. An allosteric cyclin E-CDK2 site mapped by paralog hopping with covalent probes
7. Lead Identification
8. Protein Degraders: Moving Towards Therapeutically Viable Agents
9. Chiral Sulfoxide-Induced Single Turn Peptide α-Helicity
10. Translational PK–PD for targeted protein degradation
11. Intramolecular Ring-Opening Decomposition of Aryl Azetidines
12. Targeted Covalent Enzyme Inhibitors
13. Lead Identification
14. Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes
15. A kinetic proofreading model for bispecific protein degraders
16. Amphotericin B, identified from a natural product screen, antagonizes CNS inhibitors to promote axon growth via activation of an Akt pathway in neurons
17. Intramolecular Ring-Opening Decomposition of Aryl Azetidines.
18. Phenol formation from the reactions of amino-stabilized alkenyl Fischer carbene complexes
19. Metal-catalyzed cyclopropene rearrangements for benzannulation: evaluation of an anthraquinone synthesis pathway and reevaluation of the parallel approach via carbene-chromium complexes
20. Synthesis and properties of an optically active helical bis-cobaltocenium ion
21. Synthesis and properties of optically active helical metallocene oligomers
22. Creating an integrated payment system: the evolution of Fedwire
23. Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation
24. Synthetic studies towards the total synthesis of olivin: Synthesis of a fully functionalized alkyne appropriate for the benzannulation reaction
25. Structure-Based Approach To Identify 5-[4-Hydroxyphenyl]pyrrole-2-carbonitrile Derivatives as Potent and Tissue Selective Androgen Receptor Modulators
26. Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans
27. Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition
28. Clearance Prediction of Targeted Covalent Inhibitors by In Vitro-In Vivo Extrapolation of Hepatic and Extrahepatic Clearance Mechanisms
29. Discovery of a Selective Covalent Inhibitor of Lysophospholipase-like 1 (LYPLAL1) as a Tool to Evaluate the Role of this Serine Hydrolase in Metabolism
30. Intrinsic reactivity profile of electrophilic moieties to guide covalent drug design: N-α-acetyl-l-lysine as an amine nucleophile
31. Azaindolines: derisking the indoline structural alert
32. Know your target, know your molecule
33. 3-(Pyridin-2-yl-ethynyl)benzamide metabotropic glutamate receptor 5 negative allosteric modulators: Hit to lead studies
34. Novel imidazolopyrimidines as dual PI3-Kinase/mTOR inhibitors
35. Novel purine and pyrazolo[3,4- d]pyrimidine inhibitors of PI3 kinase-α: Hit to lead studies
36. Hit to lead studies on (hetero)arylpyrimidines—Agonists of the canonical Wnt-β-catenin cellular messaging system
37. Chemical and Computational Methods for the Characterization of Covalent Reactive Groups for the Prospective Design of Irreversible Inhibitors
38. A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors
39. Recent advances in irreversible kinase inhibitors
40. 1-(2-Hydroxy-2-methyl-3-phenoxypropanoyl)indoline-4-carbonitrile Derivatives as Potent and Tissue Selective Androgen Receptor Modulators
41. Benchmarking in Vitro Covalent Binding Burden As a Tool To Assess Potential Toxicity Caused by Nonspecific Covalent Binding of Covalent Drugs
42. N-((8-Hydroxy-5-substituted-quinolin-7-yl)(phenyl)methyl)-2-phenyloxy/amino-acetamide inhibitors of ADAMTS-5 (Aggrecanase-2)
43. Palladium-catalyzed cross-coupling of arene-chromium tricarbonyl triflate complexes
44. Clearance Prediction of Targeted Covalent Inhibitors by In Vitro-In Vivo Extrapolation of Hepatic and Extrahepatic Clearance Mechanisms
45. Discovery and characterization of novel potent PARP-1 inhibitors endowed with neuroprotective properties: From TIQ-A to HYDAMTIQ
46. Advances in the development of novel aggrecanase inhibitors
47. ChemInform Abstract: Synthetic Studies Towards the Total Synthesis of Olivin Using Fischer Carbene Complexes: Synthesis of the 1,6,8-Trioxygenated Tricyclic Core via the Benzannulation Reaction.
48. ChemInform Abstract: Synthetic Studies Towards the Total Synthesis of Olivin: Synthesis of a Fully Functionalized Alkyne Appropriate for the Benzannulation Reaction.
49. ChemInform Abstract: Novel and Selective Calcitonin-Inducing Agents.
50. Amphotericin B, identified from a natural product screen, antagonizes CNS inhibitors to promote axon growthviaactivation of an Akt pathway in neurons
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