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Your search keyword '"Gilberston M"' showing total 3 results
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3 results on '"Gilberston M"'

1. Excellent outcomes in older patients with primary CNS lymphoma treated with R-MPV/cytarabine without whole brain radiotherapy or autologous stem cell transplantation therapy.

Author

Paul E., Quach H., Bazargan A., Ku M., Tey A., Shortt J., Opat S., Tam C., Filshie R., Gregory G.P., Gilberston M., Tatarczuch M., Paul E., Quach H., Bazargan A., Ku M., Tey A., Shortt J., Opat S., Tam C., Filshie R., Gregory G.P., Gilberston M., and Tatarczuch M.

Abstract

Primary CNS lymphoma (PCNSL) in immunocompetent patients is a disease of older adults who are often unsuitable for the high dose therapy or experience substantial morbidity from whole brain radiotherapy. As therapeutic studies in older patients are limited, there is a need for real world data to guide patient care. Here we report a series of 38 consecutive immunocompetent patients with PCNSL treated with curative intent using R-MPV/Ara-C with omission of consolidative radiotherapy in older patients. Outcomes for patients aged < 60 years and > 60 years were similar with overall response rates of 100% vs 85%, (p =.30), 4-year PFS of 81% vs 82% (p =.92) and 4-year OS of 80% vs 77% (p =.52) respectively. This study supports the premise that older patients with PCNSL can be effectively treated with sequential and response-adapted methotrexate (MTX) dosing without the need for WBRT or autologous stem cell transplantation (ASCT).Copyright © 2020 Informa UK Limited, trading as Taylor & Francis Group.

Published
2021

2. Occupational histories of cancer patients in a Canadian cancer treatment center and the generated hypothesis regarding breast cancer and farming

Author

Brophy, J. T., Keith, M. M., Kevin Gorey, Laukkanen, E., Hellyer, D., Watterson, A., Reinhartz, A., and Gilberston, M.

Subjects
Adult, Ontario, Occupational Exposure, Public Health, Environmental and Occupational Health, Humans, Breast Neoplasms, Female, Cancer Care Facilities, Middle Aged, Occupations, Aged, Agricultural Workers' Diseases
Abstract

Occupational exposures increase cancer risks. The Windsor Regional Cancer Centre in Windsor, Ontario, was the first Canadian cancer treatment center to collect the work histories of its patients, which were recorded using a computer-based questionnaire. Breast cancer cases represented the largest respondent group. The lifetime occupational histories of 299 women with newly diagnosed breast cancers were compared with those of 237 women with other cancers. Odds ratios (ORs) were calculated using logistic regression, adjusting for age, social class, and education. The OR for womenor = 55 years of age with breast cancer who had ever farmed, compared with women of the same age with other cancers, was 9.05 (95% CI 1.06, 77.43). Patients' occupational histories can help to inform understanding of cancer etiology and prevention. This effort points to a need for investigation of the possible association between breast cancer and agricultural hazards such as pesticides.

Published
2002

3. Excellent outcomes in older patients with primary CNS lymphoma treated with R-MPV/cytarabine without whole brain radiotherapy or autologous stem cell transplantation therapy.

Author

Tatarczuch M, Paul E, Gilberston M, Gregory GP, Tam C, Quach H, Bazargan A, Filshie R, Ku M, Tey A, Shortt J, and Opat S

Subjects
Aged, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Brain, Combined Modality Therapy, Cytarabine therapeutic use, Humans, Methotrexate therapeutic use, Stem Cell Transplantation, Transplantation, Autologous, Central Nervous System Neoplasms drug therapy, Central Nervous System Neoplasms therapy, Hematopoietic Stem Cell Transplantation
Abstract

Primary CNS lymphoma (PCNSL) in immunocompetent patients is a disease of older adults who are often unsuitable for the high dose therapy or experience substantial morbidity from whole brain radiotherapy. As therapeutic studies in older patients are limited, there is a need for real world data to guide patient care. Here we report a series of 38 consecutive immunocompetent patients with PCNSL treated with curative intent using R-MPV/Ara-C with omission of consolidative radiotherapy in older patients. Outcomes for patients aged < 60 years and > 60 years were similar with overall response rates of 100% vs 85%, ( p  = .30), 4-year PFS of 81% vs 82% ( p  = .92) and 4-year OS of 80% vs 77% ( p  = .52) respectively. This study supports the premise that older patients with PCNSL can be effectively treated with sequential and response-adapted methotrexate (MTX) dosing without the need for WBRT or autologous stem cell transplantation (ASCT).

Published
2021
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