1. 2q37 as a susceptibility locus for idiopathic basal ganglia calcification (IBGC) in a large South Tyrolean family
- Author
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Alessandro De Grandi, Giinther Schifferle, Rudolf Schönhuber, Peter P. Pramstaller, Maurizio F. Facheris, Uwe Gebert, Claudia B. Volpato, Ebba Buffone, and Andrew A. Hicks
- Subjects
Adult ,Genetic Markers ,Male ,Genetic Linkage ,DNA Mutational Analysis ,Inheritance Patterns ,Basal ganglia calcification ,Locus (genetics) ,Chromosome Disorders ,Biology ,Basal Ganglia ,Cellular and Molecular Neuroscience ,Basal Ganglia Diseases ,Genetic linkage ,Basal ganglia ,medicine ,Humans ,Genetic Predisposition to Disease ,Genetic Testing ,Aged ,Genes, Dominant ,Genetics ,Aged, 80 and over ,Chromosomes, Human, Pair 14 ,Genetic heterogeneity ,Calcinosis ,Chromosome Mapping ,Genetic Variation ,General Medicine ,Middle Aged ,medicine.disease ,Pedigree ,Italy ,Genetic Loci ,Chromosomes, Human, Pair 2 ,Mutation ,Etiology ,Susceptibility locus ,Female ,Calcification - Abstract
Familial idiopathic basal ganglia calcification (FIBGC) is an inherited neurodegenerative disorder characterized by the accumulation of calcium deposits in different brain regions, particularly in the basal ganglia. FIBGC usually follows an autosomal dominant pattern of inheritance. Despite the mapping to chromosome 14q of a susceptibility locus for IBGC (IBCG1) in one family, this locus has been excluded in several others, demonstrating genetic heterogeneity in this disorder. The etiology of this disorder thus remains largely unknown. Using a large extended multigenerational Italian family from South Tyrol with 17 affected in a total of 56 members, we performed a genome-wide linkage analysis in which we were able to exclude linkage to the IBCG1 locus on chromosome 14q and obtain evidence of a novel locus on chromosome 2q37. Electronic supplementary material. The online version of this article (doi:10.1007/s12031-009-9287-3) contains supplementary material, which is available to authorized users.
- Published
- 2009