Search

Your search keyword '"Giese N"' showing total 436 results
Start Over Author "Giese N"

Refine your results

436 results on '"Giese N"'

1. Storage Ring to Search for Electric Dipole Moments of Charged Particles -- Feasibility Study

Author

Abusaif, F., Aggarwal, A., Aksentev, A., Alberdi-Esuain, B., Andres, A., Atanasov, A., Barion, L., Basile, S., Berz, M., Böhme, C., Böker, J., Borburgh, J., Canale, N., Carli, C., Ciepał, I., Ciullo, G., Contalbrigo, M., De Conto, J. -M., Dymov, S., Felden, O., Gaisser, M., Gebel, R., Giese, N., Gooding, J., Grigoryev, K., Grzonka, D., Tahar, M. Haj, Hahnraths, T., Heberling, D., Hejny, V., Hetzel, J., Hölscher, D., Javakhishvili, O., Jorat, L., Kacharava, A., Kamerdzhiev, V., Karanth, S., Keshelashvili, I., Koop, I., Kulikov, A., Laihem, K., Lamont, M., Lehrach, A., Lenisa, P., Lomidze, I., Lomidze, N., Lorentz, B., Macharashvili, G., Magiera, A., Makino, K., Martin, S., Mchedlishvili, D., Meißner, U. -G., Metreveli, Z., Michaud, J., Müller, F., Nass, A., Natour, G., Nikolaev, N., Nogga, A., Okropiridze, D., Pesce, A., Poncza, V., Prasuhn, D., Pretz, J., Rathmann, F., Ritman, J., Rosenthal, M., Saleev, A., Schott, M., Sefzick, T., Senichev, Y., Shankar, R., Shergelashvili, D., Shmakova, V., Siddique, S., Silenko, A., Simon, M., Slim, J., Soltner, H., Stahl, A., Stassen, R., Stephenson, E., Straatmann, H., Ströher, H., Tabidze, M., Tagliente, G., Talman, R., Uzikov, Y., Valdau, Y., Valetov, E., Vilella, E., Vitz, M., Vossebeld, J., Wagner, T., Weidemann, C., Wirzba, A., Wrońska, A., Wüstner, P., Zupranski, P., and Żurek, M.

Subjects
High Energy Physics - Experiment, Nuclear Experiment, Physics - Accelerator Physics
Abstract

The proposed method exploits charged particles confined as a storage ring beam (proton, deuteron, possibly $^3$He) to search for an intrinsic electric dipole moment (EDM) aligned along the particle spin axis. Statistical sensitivities could approach 10$^{-29}$ e$\cdot$cm. The challenge will be to reduce systematic errors to similar levels. The ring will be adjusted to preserve the spin polarisation, initially parallel to the particle velocity, for times in excess of 15 minutes. Large radial electric fields, acting through the EDM, will rotate the polarisation from the longitudinal to the vertical direction. The slow rise in the vertical polarisation component, detected through scattering from a target, signals the EDM. The project strategy is outlined. A stepwise plan is foreseen, starting with ongoing COSY activities that demonstrate technical feasibility. Achievements to date include reduced polarization measurement errors, long horizontal plane polarization lifetimes, and control of the polarization direction through feedback from scattering measurements. The project continues with a proof-of-capability measurement (precursor experiment; first direct deuteron EDM measurement), an intermediate prototype ring (proof-of-principle; demonstrator for key technologies), and finally a high-precision electric-field storage ring., Comment: 243 pages

Published
2019
Full Text
View/download PDF

2. Feasibility Study for an EDM Storage Ring

Author

Abusaif, F., Aggarwal, A., Aksentev, A., Alberdi-Esuain, B., Barion, L., Basile, S., Berz, M., Beyß, M., Böhme, C., Böker, J., Borburgh, J., Carli, C., Ciepał, I., Ciullo, G., Contalbrigo, M., De Conto, J. -M., Dymov, S., Engels, R., Felden, O., Gagoshidze, M., Gaisser, M., Gebel, R., Giese, N., Grigoryev, K., Grzonka, D., Hanraths, T., Hanhart, C., Heberling, D., Hejny, V., Hetzel, J., Hölscher, D., Javakhishvili, O., Kacharava, A., Karanth, S., Käseberg, C., Kamerdzhiev, V., Keshelashvili, I., Koop, I., Kulikov, A., Laihem, K., Lamont, M., Lehrach, A., Lenisa, P., Lomidze, N., Lorentz, B., Macharashvili, G., Magiera, A., Maier, R., Makino, K., Martin, S., Mchedlishvili, D., Meißner, U. -G., Metreveli, Z., Michaud, J., Müller, F., Nass, A., Natour, G., Nikolaev, N., Nogga, A., Pesce, A., Poncza, V., Prasuhn, D., Pretz, J., Rathmann, F., Ritman, J., Rosenthal, M., Saleev, A., Schott, M., Sefzick, T., Senichev, Y., Shergelashvili, D., Shmakova, V., Siddique, S., Silenko, A., Simon, M., Slim, J., Soltner, H., Stahl, A., Stassen, R., Stephenson, E., Straatmann, H., Ströher, H., Tabidze, M., Tagliente, G., Tahar, M., Talman, R., Uzikov, Yu., Valdau, Yu., Valetov, E., Wagner, T., Weidemann, C., Wilkin, C., Wirzba, A., Wrońska, A., and Wüstner, P.

Subjects
Physics - Accelerator Physics, High Energy Physics - Experiment
Abstract

This project exploits charged particles confined as a storage ring beam (proton, deuteron, possibly $^3$He) to search for an intrinsic electric dipole moment (EDM, $\vec d$) aligned along the particle spin axis. Statistical sensitivities can approach $10^{-29}$~e$\cdot$cm. The challenge will be to reduce systematic errors to similar levels. The ring will be adjusted to preserve the spin polarization, initially parallel to the particle velocity, for times in excess of 15 minutes. Large radial electric fields, acting through the EDM, will rotate the polarization ($\vec d \times\vec E$). The slow rise in the vertical polarization component, detected through scattering from a target, signals the EDM. The project strategy is outlined. It foresees a step-wise plan, starting with ongoing COSY activities that demonstrate technical feasibility. Achievements to date include reduced polarization measurement errors, long horizontal-plane polarization lifetimes, and control of the polarization direction through feedback from the scattering measurements. The project continues with a proof-of-capability measurement (precursor experiment; first direct deuteron EDM measurement), an intermediate prototype ring (proof-of-principle; demonstrator for key technologies), and finally the high precision electric-field storage ring.

Published
2018

3. Sunspot positions and sizes for 1825-1867 from the observations by Samuel Heinrich Schwabe

Author

Arlt, R., Leussu, R., Giese, N., Mursula, K., and Usoskin, I. G.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

Samuel Heinrich Schwabe made 8486 drawings of the solar disk with sunspots in the period from November 5, 1825 to December 29, 1867. We have measured sunspot sizes and heliographic positions on digitized images of these drawings. A total of about 135,000 measurements of individual sunspots are available in a data base. Positions are accurate to about 5% of the solar radius or to about three degrees in heliographic coordinates in the solar disk center. Sizes were given in 12 classes as estimated visually with circular cursor shapes on the screen. Most of the drawings show a coordinate grid aligned with the celestial coordinate system. A subset of 1168 drawings have no indication of their orientation. We have used a Bayesian estimator to infer the orientations of the drawings as well as the average heliographic spot positions from a chain of drawings of several days, using the rotation profile of the present Sun. The data base also includes all information available from Schwabe on spotless days., Comment: 8 pages, 4 figures, Mon. Not. R. Astron. Soc., accepted

Published
2013
Full Text
View/download PDF

4. PHD3 regulates differentiation, tumour growth and angiogenesis in pancreatic cancer

Author

Su, Y, Loos, M, Giese, N, Hines, OJ, Diebold, I, Görlach, A, Metzen, E, Pastorekova, S, Friess, H, and Büchler, P

Subjects
Digestive Diseases, Cancer, Aetiology, 2.1 Biological and endogenous factors, Adenocarcinoma, Animals, Annexin A5, Apoptosis, Carcinoma, Pancreatic Ductal, Caspase 3, Cell Differentiation, Cell Line, Tumor, Dioxygenases, Enzyme-Linked Immunosorbent Assay, Humans, Hypoxia-Inducible Factor 1, alpha Subunit, Hypoxia-Inducible Factor-Proline Dioxygenases, Mice, Neoplasm Invasiveness, Neovascularization, Pathologic, Pancreatic Neoplasms, Polymerase Chain Reaction, RNA, Messenger, RNA, Neoplasm, Reverse Transcriptase Polymerase Chain Reaction, Transplantation, Heterologous, Up-Regulation, Vascular Endothelial Growth Factor A, angiogenesis, HIF-1, hypoxia, pancreatic cancer, PHD3, Oncology and Carcinogenesis, Public Health and Health Services, Oncology & Carcinogenesis
Abstract

PurposeTumour hypoxia activates hypoxia-inducible factor-1 (HIF-1) and indluences angiogenesis, cell survival and invasion. Prolyl hydroxylase-3 (PHD3) regulates degradation of HIF-1α. The effects of PHD3 in tumour growth are largely unknown.Experimental designPHD3 expression was analysed in human pancreatic cancer tissues and cancer cell lines by real-time quantitative PCR and immunohistochemistry. PHD3 overexpression was established by stable transfection and downregulation by short interfering RNA technology. VEGF was quantified by enzyme-linked immunosorbent assay. Matrigel invasion assays were performed to examine tumour cell invasion. Apoptosis was measured by annexin-V staining and caspase-3 assays. The effect of PHD3 on tumour growth in vivo was evaluated in an established orthotopic murine model.ResultsPHD3 was upregulated in well-differentiated human tumours and cell lines, and regulated hypoxic VEGF secretion. PHD3 overexpression mediated tumour cell growth and invasion by induction of apoptosis in a nerve growth factor-dependent manner by the activation of caspase-3 and phosphorylation of focal adhesion kinase HIF-1 independently. In vivo, PHD3 inhibited tumour growth by abrogation of tumour angiogenesis.ConclusionOur results indicate essential functions of PHD3 in tumour growth, apoptosis and angiogenesis and through HIF-1-dependent and HIF-1-independent pathways.

Published
2010

7. Die 5-Lipoxygenase ist ein früher Marker in der Pankreaskarzinogenese und qualifiziert als neuer Tumorpromoter

Author

Hennig, R., Ding, X. -Z., Grippo, P., Rao, S. M., Giese, N., Büchler, M. W., Friess, H., Bell, R. H., Adrian, T. E., Bruch, H. P., editor, Büchler, M. W., editor, Buhr, H. J., editor, Hohenberger, W., editor, Klar, E., editor, Kremer, B., editor, Post, S., editor, Schilling, M., editor, Schumpelick, V., editor, Siewert, J. R., editor, Thiede, A., editor, Becker, H., editor, Bittner, R., editor, Függer, R., editor, Köckerling, F., editor, Saeger, H. D., editor, Zornig, C., editor, Hölscher, A., editor, Izbicki, J. R., editor, Junginger, T., editor, Senninger, N., editor, Allgayer, H., editor, Broll, R., editor, Bruns, C. J., editor, Fries, H., editor, Kalthoff, H., editor, Schackert, H. K., editor, Ertel, W., editor, Faist, E., editor, Holzheimer, R. G., editor, Holzmann, B., editor, Schade, U. F., editor, Vollmar, B., editor, Brückner, U. B., editor, Heidecke, C. D., editor, Menger, M. D., editor, Neugebauer, E., editor, Spiegel, H. U., editor, Biemer, E., editor, Germann, G., editor, Haas, N., editor, Machens, H. G., editor, Stark, G. B., editor, Steinau, H. U., editor, Haverich, A., editor, Heberer, M., editor, Rogiers, X., editor, Jauch, K. W., editor, Roth, H., editor, von Schweinitz, D., editor, Waag, K. L., editor, Altendorf-Hofmann, A., editor, Celik, I., editor, Lehnert, T., editor, Lorenz, W., editor, Ohmann, C., editor, Bechstein, W. O., editor, Broelsch, C., editor, Hopt, U., editor, Klempnauer, J., editor, Neuhaus, P., editor, Fändrich, F., editor, Markus, B., editor, Minor, T., editor, Wonigeit, K., editor, Dralle, H., editor, Goretzki, P. E., editor, Rothmund, M., editor, Bühren, V., editor, Josten, C., editor, Muhr, G., editor, Nast-Kolb, D., editor, Stürmer, K. M., editor, Trentz, O., editor, Brunkwall, J., editor, Sandmann, W., editor, Schmitz-Rixen, T., editor, Storck, M., editor, Branscheid, D., editor, Dienemann, H., editor, Hirner, A., editor, Passlick, B., editor, Toomes, H., editor, Beyersdorf, F., editor, Hetzer, R., editor, Schäfers, H. J., editor, Zerkowski, H. R., editor, Becker, H. D., editor, Saeger, H. -D., editor, Jauch, K. -W., editor, and Bauer, H., editor

Published
2006
Full Text
View/download PDF

8. Ein neues Konzept zur Untersuchung lymphangiogener Faktoren beim Pankreaskarzinom

Author

Schneider, M., Büchler, P., Ny, A., Koch, M., Giese, N., Büchler, M. W., Friess, H., Carmeliet, P., Bruch, H. P., editor, Büchler, M. W., editor, Buhr, H. J., editor, Hohenberger, W., editor, Klar, E., editor, Kremer, B., editor, Post, S., editor, Schilling, M., editor, Schumpelick, V., editor, Siewert, J. R., editor, Thiede, A., editor, Becker, H., editor, Bittner, R., editor, Függer, R., editor, Köckerling, F., editor, Saeger, H. D., editor, Zornig, C., editor, Hölscher, A., editor, Izbicki, J. R., editor, Junginger, T., editor, Senninger, N., editor, Allgayer, H., editor, Broll, R., editor, Bruns, C. J., editor, Fries, H., editor, Kalthoff, H., editor, Schackert, H. K., editor, Ertel, W., editor, Faist, E., editor, Holzheimer, R. G., editor, Holzmann, B., editor, Schade, U. F., editor, Vollmar, B., editor, Brückner, U. B., editor, Heidecke, C. D., editor, Menger, M. D., editor, Neugebauer, E., editor, Spiegel, H. U., editor, Biemer, E., editor, Germann, G., editor, Haas, N., editor, Machens, H. G., editor, Stark, G. B., editor, Steinau, H. U., editor, Haverich, A., editor, Heberer, M., editor, Rogiers, X., editor, Jauch, K. W., editor, Roth, H., editor, von Schweinitz, D., editor, Waag, K. L., editor, Altendorf-Hofmann, A., editor, Celik, I., editor, Lehnert, T., editor, Lorenz, W., editor, Ohmann, C., editor, Bechstein, W. O., editor, Broelsch, C., editor, Hopt, U., editor, Klempnauer, J., editor, Neuhaus, P., editor, Fändrich, F., editor, Markus, B., editor, Minor, T., editor, Wonigeit, K., editor, Dralle, H., editor, Goretzki, P. E., editor, Rothmund, M., editor, Bühren, V., editor, Josten, C., editor, Muhr, G., editor, Nast-Kolb, D., editor, Stürmer, K. M., editor, Trentz, O., editor, Brunkwall, J., editor, Sandmann, W., editor, Schmitz-Rixen, T., editor, Storck, M., editor, Branscheid, D., editor, Dienemann, H., editor, Hirner, A., editor, Passlick, B., editor, Toomes, H., editor, Beyersdorf, F., editor, Hetzer, R., editor, Schäfers, H. J., editor, Zerkowski, H. R., editor, Becker, H. D., editor, Saeger, H. -D., editor, Jauch, K. -W., editor, and Bauer, H., editor

Published
2006
Full Text
View/download PDF

14. Storage Ring to Search for Electric Dipole Moments of Charged Particles -- Feasibility Study

Author

Abusaif, F., Aggarwal, A., Aksentev, A., Alberdi-Esuain, B., Atanasov, A., Barion, L., Basile, S., Berz, M., Beyß, M., Böhme, C., Böker, J., Borburgh, J., Carli, C., Ciepał, I., Ciullo, G., Contalbrigo, M., De Conto, J.-M., Dymov, S., Felden, O., Gagoshidze, M., Gaisser, M., Gebel, R., Giese, N., Grigoryev, K., Grzonka, D., Haj Tahar, M., Hahnraths, T., Heberling, D., Hejny, V., Hetzel, J., Hölscher, D., Javakhishvili, O., Jorat, L., Kacharava, A., Kamerdzhiev, V., Karanth, S., Käseberg, C., Keshelashvili, I., Koop, I., Kulikov, A., Laihem, K., Lamont, M., Lehrach, A., Lenisa, P., Lomidze, N., Lorentz, B., Macharashvili, G., Magiera, A., Makino, K., Martin, S., Mchedlishvili, D., Meißner, U.-G, Metreveli, Z., Michaud, J., Müller, F., Nass, A., Natour, G., Nikolaev, N., Nogga, A., Pesce, A., Poncza, V., Prasuhn, D., Pretz, J., Rathmann, F., Ritman, J., Rosenthal, M., Saleev, A., Schott, M., Sefzick, T., Senichev, Y., Shergelashvili, D., Shmakova, V., Siddique, S., Silenko, A., Simon, M., Slim, J., Soltner, H., Stahl, A., Stassen, R., Stephenson, E., Straatmann, H., Ströher, H., Tabidze, M., Tagliente, G., Talman, R., Uzikov, Yu., Valdau, Yu., Valetov, E., Wagner, T., Weidemann, C., Wirzba, A., Wrońska, A., Wüstner, P., Zupranski, P., Zurek., M., Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), CERN, and CPEDM

Subjects
lifetime, experimental methods, deuteron: electric moment, [PHYS.PHYS.PHYS-ACC-PH]Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph], feedback, Juelich COSY PS, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], sensitivity, charged particle, particle: spin, electric field, particle: velocity, error: statistical, synchrotron, dipole: electric, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], proposed experiment, spin: polarization
Abstract

CERN Yellow Reports: Monographs Published by CERN; International audience; The proposed method exploits charged particles confined as a storage ring beam (proton, deuteron, possibly $^3$He) to search for an intrinsic electric dipole moment (EDM) aligned along the particle spin axis. Statistical sensitivities can approach $10^{29} e$ cm. The challenge will be to reduce systematic errors to similar levels. The ring will be adjusted to preserve the spin polarization, initially parallel to the particle velocity, for times in excess of 15 minutes. Large radial electric fields, acting through the EDM, will rotate the polarization. The slow rise in the vertical polarization component, detected through scattering from a target, signals the EDM. The project strategy is outlined. It foresees a step-wise plan, starting with ongoing COSY activities that demonstrate technical feasibility. Achievements to date include reduced polarization measurement errors, long horizontal-plane polarization lifetimes, and control of the polarization direction through feedback from the scattering measurements. The project continues with a proof-of-capability measurement (precursor experiment; first direct deuteron EDM measurement), an intermediate prototype ring (proof-of-principle; demonstrator for key technologies), and finally the high precision electric-field storage ring.

Published
2021

15. Storage ring to search for electric dipole moments of charged particles: Feasibility study

Author

Monographs, CERN Yellow Reports, Abusaif, F., Böhme, C., Zupranski, P., Zurek, M., Böker, J., Borburgh, J., Canale, N., Carli, C., Ciepał, I., Ciullo, G., Contalbrigo, M., De Conto, J.-M., Dymov, S., Aggarwal, A., Felden, Olaf, Gaisser, M., Gebel, Ralf Heinz, Giese, N., Gooding, J., Grigoryev, Kirill, Grzonka, D., Haj Tahar, M., Hahnraths, T., Heberling, D., Aksentev, A., Hejny, V., Hetzel, Jan Henry, Hölscher, D., Javakhishvili, O., Jorat, L., Kacharava, A., Kamerdzhiev, Vsevolod, Karanth, S., Keshelashvili, Irakli, Koop, I., Alberdi-Esuain, B., Kulikov, A., Laihem, Karim, Lamont, M., Lehrach, A., Lenisa, P., Lomidze, I., Lomidze, N., Lorentz, B., Macharashvili, G., Magiera, A., Andres, A., Makino, K., Martin, S., Mchedlishvili, D., Meißner, U.-G., Metreveli, Z., Michaud, J., Müller, F., Nass, A., Natour, G., Nikolaev, N., Atanasov, A., Nogga, A., Okropiridze, Dachi, Pesce, A., Poncza, V., Prasuhn, Dieter, Pretz, J., Rathmann, F., Ritman, James, Rosenthal, M., Saleev, A., Barion, L., Schott, M., Sefzick, T., Senichev, Y., Shankar, R., Shergelashvili, D., Shmakova, V., Siddique, Saad, Silenko, A., Simon, M., Slim, Jamal, Basile, S., Soltner, H., Stahl, A., Stassen, Rolf, Stephenson, E., Straatmann, H., Ströher, Hans, Tabidze, M., Tagliente, G., Talman, R., Uzikov, Y., Berz, M., Valdau, Yury, Valetov, E., Vilella, E., Vitz, M., Vossebeld, J., Wagner, Tim, Weidemann, C., Wirzba, A., Wronska, A., and Wüstner, P.

Abstract

Geneva : CERN Yellow Reports: Monographs 22MB (2021). doi:10.23731/CYRM-2021-003, Published by CERN Yellow Reports: Monographs, Geneva

Published
2021
Full Text
View/download PDF

18. CXC-Chemokine CXCL14, CXCL16 und Disintegrin-ähnliche Metalloproteinase ADAM10 — Expression, Funktion und Interaktion bei der Karzinogenese des Pankreaskarzinoms

Author

Wente, Moritz N., Gaida, M. M., Mayer, C., Haag, N., Giese, N. A., Bergmann, F., Giese, T., Schmidt, J., Friess, H., Bruch, H. P., editor, Büchler, M. W., editor, Buhr, H. J., editor, Hohenberger, W., editor, Klar, E., editor, Post, S., editor, Schilling, M., editor, Schumpelick, V., editor, Siewert, J. R., editor, Thiede, A., editor, Becker, H., editor, Bittner, R., editor, Függer, R., editor, Köckerling, F., editor, Saeger, H. D., editor, Zornig, C., editor, Hölscher, A., editor, Izbicki, J. R., editor, Jauch, K. W., editor, Senninger, N., editor, Allgayer, H., editor, Bruns, C. J., editor, Celik, I., editor, Fries, H., editor, Kalthoff, H., editor, Schackert, H. K., editor, Brückner, U. B., editor, Ertel, W., editor, Faist, E., editor, Holzheimer, R. G., editor, Holzmann, B., editor, Schade, U. F., editor, Vollmar, B., editor, Heidecke, C. D., editor, Menger, M. D., editor, Neugebauer, E., editor, Spiegel, H. U., editor, Germann, G., editor, Haas, N., editor, Langer, S., editor, Machens, H. G., editor, Stark, G. B., editor, Steinau, H. U., editor, Haverich, A., editor, Heberer, M., editor, Fitze, G., editor, Roth, H., editor, von Schweinitz, D., editor, Waag, K. L., editor, Altendorf-Hofmann, A., editor, Lehnert, T., editor, Lorenz, W., editor, Ohmann, C., editor, Bechstein, W. O., editor, Broelsch, C., editor, Hopt, U., editor, Klempnauer, J., editor, Fändrich, F., editor, Markus, B., editor, Minor, T., editor, Neuhaus, P., editor, Wonigeit, K., editor, Dralle, H., editor, Goretzki, P. E., editor, Rothmund, M., editor, Bühren, V., editor, Josten, C., editor, Muhr, G., editor, Nast-Kolb, D., editor, Stürmer, K. M., editor, Trentz, O., editor, Brunkwall, J., editor, Sandmann, W., editor, Schmitz-Rixen, T., editor, Storck, M., editor, Branscheid, D., editor, Dienemann, H., editor, Hirner, A., editor, Passlick, B., editor, Toomes, H., editor, Beyersdorf, F., editor, Hetzer, R., editor, Schäfers, H. J., editor, Steinsträßer, L., editor, Vogt, P., editor, Arbogast, R., editor, and Bauer, H., editor

Published
2008
Full Text
View/download PDF

19. Expression und Funktion des Chemokin-Rezeptors CXCR6 auf polymorphkernigen neutrophilen Granulozyten (PMN) — ein lokales Ereignis im Pankreaskarzinom und in akuten Infekten

Author

Gaida, Matthias M., Günther, F., Wagner, C., Giese, N. A., Hänsch, G. M., Schmidt, J., Friess, H., Wente, M. N., Bruch, H. P., editor, Büchler, M. W., editor, Buhr, H. J., editor, Hohenberger, W., editor, Klar, E., editor, Post, S., editor, Schilling, M., editor, Schumpelick, V., editor, Siewert, J. R., editor, Thiede, A., editor, Becker, H., editor, Bittner, R., editor, Függer, R., editor, Köckerling, F., editor, Saeger, H. D., editor, Zornig, C., editor, Hölscher, A., editor, Izbicki, J. R., editor, Jauch, K. W., editor, Senninger, N., editor, Allgayer, H., editor, Bruns, C. J., editor, Celik, I., editor, Fries, H., editor, Kalthoff, H., editor, Schackert, H. K., editor, Brückner, U. B., editor, Ertel, W., editor, Faist, E., editor, Holzheimer, R. G., editor, Holzmann, B., editor, Schade, U. F., editor, Vollmar, B., editor, Heidecke, C. D., editor, Menger, M. D., editor, Neugebauer, E., editor, Spiegel, H. U., editor, Germann, G., editor, Haas, N., editor, Langer, S., editor, Machens, H. G., editor, Stark, G. B., editor, Steinau, H. U., editor, Haverich, A., editor, Heberer, M., editor, Fitze, G., editor, Roth, H., editor, von Schweinitz, D., editor, Waag, K. L., editor, Altendorf-Hofmann, A., editor, Lehnert, T., editor, Lorenz, W., editor, Ohmann, C., editor, Bechstein, W. O., editor, Broelsch, C., editor, Hopt, U., editor, Klempnauer, J., editor, Fändrich, F., editor, Markus, B., editor, Minor, T., editor, Neuhaus, P., editor, Wonigeit, K., editor, Dralle, H., editor, Goretzki, P. E., editor, Rothmund, M., editor, Bühren, V., editor, Josten, C., editor, Muhr, G., editor, Nast-Kolb, D., editor, Stürmer, K. M., editor, Trentz, O., editor, Brunkwall, J., editor, Sandmann, W., editor, Schmitz-Rixen, T., editor, Storck, M., editor, Branscheid, D., editor, Dienemann, H., editor, Hirner, A., editor, Passlick, B., editor, Toomes, H., editor, Beyersdorf, F., editor, Hetzer, R., editor, Schäfers, H. J., editor, Steinsträßer, L., editor, Vogt, P., editor, Arbogast, R., editor, and Bauer, H., editor

Published
2008
Full Text
View/download PDF

24. Genome-wide association study identifies an early onset pancreatic cancer risk locus

Author

Campa, D. Gentiluomo, M. Obazee, O. Ballerini, A. Vodickova, L. Hegyi, P. Soucek, P. Brenner, H. Milanetto, A.C. Landi, S. Gao, X. Bozzato, D. Capurso, G. Tavano, F. Vashist, Y. Hackert, T. Bambi, F. Bursi, S. Oliverius, M. Gioffreda, D. Schöttker, B. Ivanauskas, A. Mohelnikova-Duchonova, B. Darvasi, E. Pezzilli, R. Małecka-Panas, E. Strobel, O. Gazouli, M. Katzke, V. Szentesi, A. Cavestro, G.M. Farkas, G., Jr. Izbicki, J.R. Moz, S. Archibugi, L. Hlavac, V. Vincze, Á. Talar-Wojnarowska, R. Rusev, B. Kupcinskas, J. Greenhalf, B. Dijk, F. Giese, N. Boggi, U. Andriulli, A. Busch, O.R. Vanella, G. Vodicka, P. Nentwich, M. Lawlor, R.T. Theodoropoulos, G.E. Jamroziak, K. Zuppardo, R.A. Moletta, L. Ginocchi, L. Kaaks, R. Neoptolemos, J.P. Lucchesi, M. Canzian, F.

Abstract

Early onset pancreatic cancer (EOPC) is a rare disease with a very high mortality rate. Almost nothing is known on the genetic susceptibility of EOPC, therefore, we performed a genome-wide association study (GWAS) to identify novel genetic variants specific for patients diagnosed with pancreatic ductal adenocarcinoma (PDAC) at younger ages. In the first phase, conducted on 821 cases with age of onset ≤60 years, of whom 198 with age of onset ≤50, and 3227 controls from PanScan I-II, we observed four SNPs (rs7155613, rs2328991, rs4891017 and rs12610094) showing an association with EOPC risk (P < 1 × 10−4). We replicated these SNPs in the PANcreatic Disease ReseArch (PANDoRA) consortium and used additional in silico data from PanScan III and PanC4. Among these four variants rs2328991 was significant in an independent set of 855 cases with age of onset ≤60 years, of whom 265 with age of onset ≤50, and 4142 controls from the PANDoRA consortium while in the in silico data, we observed no statistically significant association. However, the resulting meta-analysis supported the association (P = 1.15 × 10−4). In conclusion, we propose a novel variant rs2328991 to be involved in EOPC risk. Even though it was not possible to find a mechanistic link between the variant and the function, the association is supported by a solid statistical significance obtained in the largest study on EOPC genetics present so far in the literature. © 2020 UICC

Published
2020

25. Semaphorin 3A erhöht die Invasivität des humanen Pankreaskarzinoms

Author

Müller, M. W., Giese, N., Ceyhan, G., Swiercz, J. M., Hinz, U., Giese, T., Büchler, M. W., Offermanns, S., Friess, H., Bruch, H. P., editor, Büchler, M. W., editor, Buhr, H. J., editor, Hohenberger, W., editor, Klar, E., editor, Kremer, B., editor, Post, S., editor, Schilling, M., editor, Schumpelick, V., editor, Siewert, J. R., editor, Thiede, A., editor, Becker, H., editor, Bittner, R., editor, Függer, R., editor, Köckerling, F., editor, Saeger, H. D., editor, Zornig, C., editor, Hölscher, A., editor, Izbicki, J. R., editor, Junginger, T., editor, Senninger, N., editor, Allgayer, H., editor, Broll, R., editor, Bruns, C. J., editor, Fries, H., editor, Kalthoff, H., editor, Schackert, H. K., editor, Ertel, W., editor, Faist, E., editor, Holzheimer, R. G., editor, Holzmann, B., editor, Schade, U. F., editor, Vollmar, B., editor, Brückner, U. B., editor, Heidecke, C. D., editor, Menger, M. D., editor, Neugebauer, E., editor, Spiegel, H. U., editor, Biemer, E., editor, Germann, G., editor, Haas, N., editor, Machens, H. G., editor, Stark, G. B., editor, Steinau, H. U., editor, Haverich, A., editor, Heberer, M., editor, Rogiers, X., editor, Jauch, K. W., editor, Roth, H., editor, von Schweinitz, D., editor, Waag, K. L., editor, Altendorf-Hofmann, A., editor, Celik, I., editor, Lehnert, T., editor, Lorenz, W., editor, Ohmann, C., editor, Bechstein, W. O., editor, Broelsch, C., editor, Hopt, U., editor, Klempnauer, J., editor, Neuhaus, P., editor, Fändrich, F., editor, Markus, B., editor, Minor, T., editor, Wonigeit, K., editor, Dralle, H., editor, Goretzki, P. E., editor, Rothmund, M., editor, Bühren, V., editor, Josten, C., editor, Muhr, G., editor, Nast-Kolb, D., editor, Stürmer, K. M., editor, Trentz, O., editor, Brunkwall, J., editor, Sandmann, W., editor, Schmitz-Rixen, T., editor, Storck, M., editor, Branscheid, D., editor, Dienemann, H., editor, Hirner, A., editor, Passlick, B., editor, Toomes, H., editor, Beyersdorf, F., editor, Hetzer, R., editor, Schäfers, H. J., editor, Zerkowski, H. R., editor, Becker, H. D., editor, Saeger, H. -D., editor, Jauch, K. -W., editor, and Bauer, H., editor

Published
2006
Full Text
View/download PDF

38. Feasibility Study for an EDM Storage Ring

Author

Abusaif, F., Aggarwal, A., Aksentev, A., Alberdi-Esuain, B., Barion, L., Basile, S., Berz, M., Beyß, M., Böhme, C., Böker, J., Borburgh, J., Carli, C., Ciepał, I., Ciullo, G., Contalbrigo, M., M Conto, J., Dymov, S., Engels, R., Felden, O., Gagoshidze, M., Gaisser, M., Gebel, R., Giese, N., Grigoryev, K., Grzonka, D., Hanraths, T., Hanhart, C., Heberling, D., Hejny, V., Hetzel, J., Hölscher, D., Otari Javakhishvili, Kacharava, A., Karanth, S., Käseberg, C., Kamerdzhiev, V., Keshelashvili, I., Koop, I., Kulikov, A., Laihem, K., Lamont, M., Lehrach, A., Lenisa, P., Lomidze, N., Lorentz, B., Macharashvili, G., Magiera, A., Maier, R., Makino, K., Martin, S., Mchedlishvili, D., G Meißner, U., Metreveli, Z., Michaud, J., Müller, F., Nass, A., Natour, G., Nikolaev, N., Nogga, A., Pesce, A., Poncza, V., Prasuhn, D., Pretz, J., Rathmann, F., Ritman, J., Rosenthal, M., Saleev, A., Schott, M., Sefzick, T., Senichev, Y., Shergelashvili, D., Shmakova, V., Siddique, S., Silenko, A., Simon, M., Slim, J., Soltner, H., Stahl, A., Stassen, R., Stephenson, E., Straatmann, H., Ströher, H., Tabidze, M., Tagliente, G., Tahar, M., Talman, R., Yu. Uzikov, Yu. Valdau, Valetov, E., Wagner, T., Weidemann, C., Wilkin, C., Wirzba, A., Wrońska, A., Wüstner, P., Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), and CPEDM

Subjects
Accelerator Physics (physics.acc-ph), experimental methods, deuteron: electric moment, hep-ex, [PHYS.PHYS.PHYS-ACC-PH]Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph], FOS: Physical sciences, costs, Juelich COSY PS, sensitivity, Accelerators and Storage Rings, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), beam optics, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Physics - Accelerator Physics, spin: polarization, Nuclear Experiment, Particle Physics - Experiment, accelerator: design, activity report, physics.acc-ph
Abstract

This project exploits charged particles confined as a storage ring beam (proton, deuteron, possibly $^3$He) to search for an intrinsic electric dipole moment (EDM, $\vec d$) aligned along the particle spin axis. Statistical sensitivities can approach $10^{-29}$~e$\cdot$cm. The challenge will be to reduce systematic errors to similar levels. The ring will be adjusted to preserve the spin polarization, initially parallel to the particle velocity, for times in excess of 15 minutes. Large radial electric fields, acting through the EDM, will rotate the polarization ($\vec d \times\vec E$). The slow rise in the vertical polarization component, detected through scattering from a target, signals the EDM. The project strategy is outlined. It foresees a step-wise plan, starting with ongoing COSY activities that demonstrate technical feasibility. Achievements to date include reduced polarization measurement errors, long horizontal-plane polarization lifetimes, and control of the polarization direction through feedback from the scattering measurements. The project continues with a proof-of-capability measurement (precursor experiment; first direct deuteron EDM measurement), an intermediate prototype ring (proof-of-principle; demonstrator for key technologies), and finally the high precision electric-field storage ring.

Published
2019

39. Genome-wide association study identifies an early onset pancreatic cancer risk locus

Author

Gentiluomo, M., Obazee, O., Ballerini, A., Vodickova, L., Hegyi, P., Soucek, P., Brenner, H., Milanetto, A. C., Landi, S., Gao, X., Bozzato, D., Capurso, G., Tavano, F., Vashist, Y., Hackert, T., Bambi, F., Bursi, S., Oliverius, M., Gioffreda, D., Schöttker, B., Ivanauskas, A., Mohelnikova-Duchonova, B., Darvasi, E., Pezzilli, R., Małecka-Panas, E., Strobel, O., Gazouli, M., Katzke, V., Szentesi, A., Cavestro, G. M., Farkas, G. Jr., Izbicki, J. R., Moz, S., Archibugi, L., Hlavac, V., Vincze, A., Talar-Wojnarowska, R., Borislav, R., Kupcinskas, J., Greenhalf, B., Dijk, F., Giese, N., Boggi, U., Andriulli, A., Busch, O. R., Vanella, G., Vodicka, P., Nentwich, M., Lawlor, R. T., Theodoropoulos, G. E., Jamroziak, K., Zuppardo, R. A., Moletta, L., Ginocchi, L., Kaaks, R., Neoptolemos, J. P., Lucchesi, M., Canzian, F., and Campa, D.

Published
2019

Catalog

Books, media, physical & digital resources
See catalog results