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Your search keyword '"Gierer, Stefanie"' showing total 9 results
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9 results on '"Gierer, Stefanie"'

3. Lack of MERS coronavirus neutralizing antibodies in humans, eastern province, Saudi Arabia

Author

Gierer, Stefanie, Hofmann-Winkler, Heike, Albuali, Waleed H., Bertram, Stephanie, Rubaish, Abdullah M. Al-, Yousef, Abdullah A., Nafaie, Awatif N. Al-, Ali, Amein K. Al-, Obeid, Obeid E., Alkharsah, Khaled R., and Pohlmann, Stefan

Subjects
Viral antibodies -- Health aspects, Infection -- Health aspects, Antibodies -- Health aspects, Health, World Health Organization
Abstract

The emergence of the Middle East respiratory syndrome coronavirus (MERS-CoV, formerly termed EMC coronavirus [1]) could pose a serious threat to public health (2). As of September 2013, a total [...]

Published
2013
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6. TMPRSS2 Activates the Human Coronavirus 229E for Cathepsin-Independent Host Cell Entry and Is Expressed in Viral Target Cells in the Respiratory Epithelium

Author

Bertram, Stephanie, primary, Dijkman, Ronald, additional, Habjan, Matthias, additional, Heurich, Adeline, additional, Gierer, Stefanie, additional, Glowacka, Ilona, additional, Welsch, Kathrin, additional, Winkler, Michael, additional, Schneider, Heike, additional, Hofmann-Winkler, Heike, additional, Thiel, Volker, additional, and Pöhlmann, Stefan, additional

Published
2013
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7. The Spike Protein of the Emerging Betacoronavirus EMC Uses a Novel Coronavirus Receptor for Entry, Can Be Activated by TMPRSS2, and Is Targeted by Neutralizing Antibodies

Author

Gierer, Stefanie, primary, Bertram, Stephanie, additional, Kaup, Franziska, additional, Wrensch, Florian, additional, Heurich, Adeline, additional, Krämer-Kühl, Annika, additional, Welsch, Kathrin, additional, Winkler, Michael, additional, Meyer, Benjamin, additional, Drosten, Christian, additional, Dittmer, Ulf, additional, von Hahn, Thomas, additional, Simmons, Graham, additional, Hofmann, Heike, additional, and Pöhlmann, Stefan, additional

Published
2013
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8. Influenza and SARS-Coronavirus Activating Proteases TMPRSS2 and HAT Are Expressed at Multiple Sites in Human Respiratory and Gastrointestinal Tracts

Author

Bertram, Stephanie, primary, Heurich, Adeline, additional, Lavender, Hayley, additional, Gierer, Stefanie, additional, Danisch, Simon, additional, Perin, Paula, additional, Lucas, Jared M., additional, Nelson, Peter S., additional, Pöhlmann, Stefan, additional, and Soilleux, Elizabeth J., additional

Published
2012
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9. Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts

Author

Bertram, Stephanie, Heurich, Adeline, Lavender, Hayley, Gierer, Stefanie, Danisch, Simon, Perin, Paula, Lucas, Jared M, Nelson, Peter S, Pöhlmann, Stefan, and Soilleux, Elizabeth J

Subjects
Swine, viruses, Respiratory System, Serine Endopeptidases, virus diseases, Gene Expression, Peptidyl-Dipeptidase A, urologic and male genital diseases, Orthomyxoviridae, Severe Acute Respiratory Syndrome, 3. Good health, Cell Line, Birds, Enzyme Activation, Gastrointestinal Tract, Severe acute respiratory syndrome-related coronavirus, Influenza, Human, Sialic Acids, Animals, Humans, Receptors, Virus, Angiotensin-Converting Enzyme 2, Disease Reservoirs
Abstract

The type II transmembrane serine proteases TMPRSS2 and HAT activate influenza viruses and the SARS-coronavirus (TMPRSS2) in cell culture and may play an important role in viral spread and pathogenesis in the infected host. However, it is at present largely unclear to what extent these proteases are expressed in viral target cells in human tissues. Here, we show that both HAT and TMPRSS2 are coexpressed with 2,6-linked sialic acids, the major receptor determinant of human influenza viruses, throughout the human respiratory tract. Similarly, coexpression of ACE2, the SARS-coronavirus receptor, and TMPRSS2 was frequently found in the upper and lower aerodigestive tract, with the exception of the vocal folds, epiglottis and trachea. Finally, activation of influenza virus was conserved between human, avian and porcine TMPRSS2, suggesting that this protease might activate influenza virus in reservoir-, intermediate- and human hosts. In sum, our results show that TMPRSS2 and HAT are expressed by important influenza and SARS-coronavirus target cells and could thus support viral spread in the human host.

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