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This article reflects on the practice of teaching and learning cultural studies in the context of South Africa. It reflects on the curriculum design and teaching experiences of the "Cultural Studies in Practice" module of the Bachelor of Social Sciences Honors in Culture, Communication and Media Studies offered at the University of KwaZulu-Natal. The module is centered around a compulsory three-day field trip to the KwaZulu-Natal Battlefields Route in South Africa. While the battlefields visited are commemorations of past military mobilities, this article reflects on how mobilities is central to the curriculum design, pedagogies, and practices of the cultural studies module through (1) the field trip and (2) the mobile pedagogy of walking. [ABSTRACT FROM AUTHOR]

The past decade or so has seen a proliferation of introductions, handbooks, and companions to mobilities studies, all of which have played a crucial role in defining and developing the field.1 These overviews have proved especially important in maintaining the purpose and integrity of mobilities scholarship as it has expanded into a multidisciplinary phenomenon whose status ("paradigm"? "subject area"? "field"?) has become increasingly hard to pin down.2 Over time, these multiple applications and interventions have added ever more depth and complexity to what mobilities—as an interpretative framework—can achieve, but its popularization has not been without risk. For example, there has been a tendency within (some) humanities research for "mobility" to be understood merely as a synonym for movement (e.g., transport, travel, migration, etc.) rather than the complex system of power- inscribed social, discursive, and political mobile practices envisaged by Tim Cresswell, Mimi Sheller, John Urry, and Peter Adey (albeit in slightly different ways).3 Handbooks, encyclopedias, and special issues are thus invaluable in keeping the principles that first informed mobilities scholarship in view to new generations of scholars, and it is our hope that this double issue—on mobilities and/as pedagogy—will make a distinctive contribution to these ongoing debates. As every teacher knows, the "classroom" (broadly conceived) is the one place where it is impossible to "fudge" what a concept—or body of knowledge—means and why it matters, and we believe the nine articles gathered together here make an excellent case for why attention to pedagogy is a sure means of maintaining the rigor, as well as the innovation, of mobilities scholarship. Although the second decade of mobilities research gave rise to several important publications on "mobile methods" more widely, this is the first publication to focus specifically on pedagogy, even though most of us who conduct research in the field also incorporate it into our teaching and public engagement work. [ABSTRACT FROM AUTHOR]

There are concerns globally about the emotional wellbeing and mental health of young people and in this paper a critical orientation comprises both theoretical and empirical data sources. The case is made that (1) the medical model of mental health – that of problem identification, diagnosis and medical treatment at the level of the individual – is not appropriate for the vast majority of children and young people in schools and (2) relational approaches would be more sensitive in responding to the complexity of the 'conditions' in the schools, homes and communities in which young people live. Articulations of these conditions in the literature are explored while we also draw on empirical data from part of an evaluation of a school‐based teacher‐training programme in which interviewees and respondents mapped out their own conditions for emotional wellbeing and mental health. We conclude with proposals for relational approaches which (1) acknowledge the links between affect, cognition and school climate and culture, (2) foreground mental health and poverty as impacting on young people's emotional wellbeing in their communities, families and schools and (3) attend to voice – providing spaces in which young people can develop their own 'preferred narratives' concerning emotional wellbeing and mental health. [ABSTRACT FROM AUTHOR]

In ultraviolet (UV) spectropolarimetric observations of the solar corona, the existence of a magnetic field, solar wind velocity, and temperature anisotropies modify the linear polarization associated with resonant scattering. Unlike previous empirical models or global models, which present blended results of the above physical effects, in this work, we forward-model expected signals in the H i Lyα line (121.6 nm) by adopting an analytic model that can be adjusted to test the roles of different effects separately. We find that the impact of all three effects is most evident in the rotation of the linear polarization direction. In particular, (1) for magnetic fields between ∼10 and ∼100 G, the Hanle effect modifies the linear polarization at low coronal heights, rotating the linear polarization direction clockwise (counterclockwise) when the angle between the magnetic field and the local vertical is greater (less) than the van Vleck angle, which is consistent with the result of Zhao et al.; (2) solar wind velocity, which increases with height, has a significant effect through the Doppler dimming effect at higher coronal heights, rotating the linear polarization direction in an opposite fashion to the Hanle effect; and (3) kinetic temperature anisotropies are most significant at lower heights in open nonradial magnetic field regions, producing tilt opposite to isotropic Doppler dimming. The fact that the three effects operate differently in distinct spatial regimes opens up the possibility for using linear polarization measurements in UV lines to diagnose these important physical characteristics of the solar corona. [ABSTRACT FROM AUTHOR]

Turino's ([2008]. Music as Social Life: The Politics of Participation. Chicago: University of Chicago Press.) distinctions between live and recorded fields can act as an effective framework for furthering academic understandings of how music teaching and learning has been impacted by the shift to online musical practice due to COVID-19 pandemic restrictions. This study investigates the effect this has had on Ethno World, JM-International's programme for folk, world and traditional music. They support youth folk music gatherings in over 23 countries and responded to the restrictions by devising 'The Hope sessions', online tune learning workshops, and the 'Exchange sessions', online folk music collaborations. This research is a hybrid ethnographic investigation of these two programmes. Hybrid ethnography is situated in a digital and physical environment (Przbylski, [2021]. Hybrid Ethnography: Online, Offline and In Between. SAGE Publications.). Data was gathered through online participant observation and interviews with artistic mentors and co-ordinators of the online programmes. Findings reveal a tension between values of inclusivity and aesthetic quality suggesting artistic mentors have needed to adjust their goals, conceptions and roles within the musical practice. These findings provide timely insight into how pedagogical approaches change when they shift from an offline to online context. [ABSTRACT FROM AUTHOR]

The changing magnetic fields of the Sun are generated and maintained by a solar dynamo, the exact nature of which remains an unsolved fundamental problem in solar physics. Our objective in this paper is to investigate the role and impact of converging flows toward Bipolar Magnetic Regions (BMR inflows) on the Sun's global solar dynamo. These flows are large-scale physical phenomena that have been observed and so should be included in any comprehensive solar dynamo model. We have augmented the Surface flux Transport And Babcock–LEighton (STABLE) dynamo model to study the nonlinear feedback effect of BMR inflows with magnitudes varying with surface magnetic fields. This fully-3D realistic dynamo model produces the sunspot butterfly diagram and allows a study of the relative roles of dynamo saturation mechanisms such as tilt-angle quenching and BMR inflows. The results of our STABLE simulations show that magnetic field-dependent BMR inflows significantly affect the evolution of the BMRs themselves and result in a reduced buildup of the global poloidal field due to local flux cancellation within the BMRs, to an extent that is sufficient to saturate the dynamo. As a consequence, for the first time, we have achieved fully 3D solar dynamo solutions, in which BMR inflows alone regulate the amplitudes and periods of the magnetic cycles. [ABSTRACT FROM AUTHOR]

Using the McIntosh Archive of solar features, we analyze the evolution of coronal holes over more than three solar cycles. We demonstrate that coronal-hole positions and lifetimes change significantly on time scales from months to years, and that the pattern of these changes is clearly linked to the solar-activity cycle. We demonstrate that the lifetimes of low-latitude coronal holes are usually less than one rotation but may extend to almost three years. When plotted over time, the positions of low-latitude coronal holes that remain visible for over one rotation track the sunspot butterfly diagram in terms of their positions on the Sun over a solar cycle. Finally, we confirm that coronal holes do not in general rigidly rotate. [ABSTRACT FROM AUTHOR]

Objectives: Primary cutaneous marginal zone lymphoma (PCMZL) is 1 of the 3 major subtypes of primary cutaneous B-cell lymphoma. The diagnosis of PCMZL may be challenging, as the differential diagnosis includes benign cutaneous lymphoproliferations as well as other primary or secondary cutaneous B-cell or T-cell lymphomas. This review describes our approach to the diagnosis of PCMZL.Methods: Two cases are presented that illustrate how we diagnose each of the 2 subtypes of PCMZL. The clinicopathologic features of PCMZL and the ways in which these cases can be distinguished from both benign and other neoplastic entities are emphasized.Results: A definitive diagnosis of PCMZL requires the incorporation of histologic and immunophenotypic features, molecular genetic studies in some cases, and just as importantly, clinical findings. Emerging data suggest that the heavy chain class-switched cases may be more like a clonal chronic lymphoproliferative disorder.Conclusions: The 2 subtypes of PCMZL create different diagnostic challenges and require the use of a multiparameter approach. Although very indolent, it is important to distinguish PCMZLs from reactive proliferations, because they frequently recur and may require antineoplastic therapies. It is also critical to distinguish PCMZLs from other B- or T-cell lymphomas so that patients are properly evaluated and not overtreated. [ABSTRACT FROM AUTHOR]

We have analyzed 33 cavities observed between 2012 and 2018, from solar activity maximum to minimum. For each cavity we applied a differential emission measure method to obtain both a temperature distribution and a value of the average temperature. We find that cavities are filled with material hotter than the surrounding streamer, with temperatures in the range of 1.67 – 2.15 MK. Differences between temperatures of cavities and surrounding streamers are in the range of 0.11 – 0.32 MK with an average value of 0.21 MK. We found that temperatures of both, cavities and streamers, vary as a function of different phases of solar activity. During solar maximum the structures are slightly hotter than those observed during solar minimum (1.85 – 2.15 MK vs. 1.67 – 1.88 MK for cavities and streamers, respectively). [ABSTRACT FROM AUTHOR]

Purpose: Psychotherapy assessments are key decision points for both clients and services, carrying considerable weight on both sides. Limited research indicates that assessments have immediate and long-term impacts on clients, particularly where trauma has been experienced, affecting engagement with therapy. Understanding assessments from clients' perspectives can inform service development and improve client experience. Methods: This is a survivor-led exploration of clients' experiences of undergoing assessment for talking therapies. Interviews were conducted with seven people who had undergone assessment for psychological therapies in third sector and NHS services. Interviews were recorded, transcribed and analysed thematically. Results: The core theme was 'respect for the journey' reflecting the need expressed by participants for their life experiences prior to the assessment to be given full respect and consideration. Six sub-themes were identified: trauma and desperation, fear of judgement, search for trust and safety, sharing and withholding (a balancing act), feeling deconstructed, and finding hope. Conclusions: The findings highlight the heightened emotional power surrounding psychotherapy assessments, reflecting the journey participants had undertaken to reach this point. The dilemma facing clients at the heart of an assessment—how much to share and how much to withhold—demonstrates the importance for services and assessors of treating the journey a client has made to the assessment with care and respect. Findings indicate the value of services and practitioners undertaking a trauma-informed approach to assessment encounters. [ABSTRACT FROM AUTHOR]

The Sun's outer atmosphere is heated to temperatures of millions of degrees, and solar plasma flows out into interplanetary space at supersonic speeds. This paper reviews our current understanding of these interrelated problems: coronal heating and the acceleration of the ambient solar wind. We also discuss where the community stands in its ability to forecast how variations in the solar wind (i.e., fast and slow wind streams) impact the Earth. Although the last few decades have seen significant progress in observations and modeling, we still do not have a complete understanding of the relevant physical processes, nor do we have a quantitatively precise census of which coronal structures contribute to specific types of solar wind. Fast streams are known to be connected to the central regions of large coronal holes. Slow streams, however, appear to come from a wide range of sources, including streamers, pseudostreamers, coronal loops, active regions, and coronal hole boundaries. Complicating our understanding even more is the fact that processes such as turbulence, stream-stream interactions, and Coulomb collisions can make it difficult to unambiguously map a parcel measured at 1 AU back down to its coronal source. We also review recent progress-in theoretical modeling, observational data analysis, and forecasting techniques that sit at the interface between data and theory-that gives us hope that the above problems are indeed solvable. [ABSTRACT FROM AUTHOR]

Objectives: To examine levels of bacterial contamination in formula feeding bottles in Sidoarjo, East Java, and to assess the preparation practices that may have been responsible.Methods: A cross-sectional study was conducted among 92 randomly selected households with children under the age of two who were bottle-fed formula. In each household, we carried out video observation of mothers/caregivers preparing bottles, and examined samples of formula for coliform bacteria and Escherichia coli (E. coli). In-depth interviews were conducted with a subsample of 20 mothers.Results: A total of 88% of the formula feeds were contaminated with total coliforms at a level >10 MPN/ml, and 45% contained E. coli. These feeds were defined as 'unfit for human consumption'. In the video observations, none of the mothers complied with all five WHO-recommended measures of hygienic formula feed preparation. Only two mothers washed their hands with soap prior to formula preparation. Most mothers also failed to clean or sterilise the bottle and clean the preparation area. In-depth interviews confirmed that such suboptimal hygiene practices were common.Conclusion: The high levels of contamination found highlight that bottles are an important faecal-oral exposure pathway resulting from poor hygiene practices during bottle preparation. [ABSTRACT FROM AUTHOR]

The actinopterygian fish †Hemicalypterus weiri Schaeffer, 1967 is herein redescribed and rediagnosed based on new information collected from reexamination of museum specimens as well as examination of recently collected specimens from the Upper Triassic Chinle Formation of San Juan County, Utah, United States. †Hemicalypterus is distinguishable by its deep, disc-shaped compressed body; ganoid-scaled anterior half and scaleless posterior half; spinose, prominent dorsal and ventral ridge scales anterior to dorsal and anal fins; hem-like dorsal and anal fins with rounded distal margins; small mouth gape; and specialized, multicuspid dentition. This type of dentition, when observed in extant fishes, is often associated with herbivory, and †Hemicalypterus represents the oldest known ray-finned fish to have possibly exploited an herbivorous trophic feeding niche. A phylogenetic analysis infers a placement of †Hemicalypterus within †Dapediiformes, with †Dapediiformes being recovered as sister to Ginglymodi within holostean actinopterygians. [ABSTRACT FROM AUTHOR]

In contrast to 2,3-dihydroxypyridine, the 3-benzyloxy protected derivative, 2 , undergoes facile alkylation at ambient temperatures with a variety of functionalized alkyl halides in good yields. This alkylation has been used to prepare a number of linkers that permit the attachment of 3,2-HOPO moieties onto various scaffolds using a wide range of coupling methods. The Mitsunobu reaction of 2 with representative alcohols was found to be of limited value due to competing O-alkylation that led to product mixtures. The phthalimide 3j can be converted in two steps to HOPO isocyanate 6 in excellent yields. Isocyanate 6 can be coupled to amines at room temperature or to alcohols in refluxing dichloroethane to obtain the corresponding urea or carbamate linked ligand systems. The coupling of isocyanate 6 with TREN followed by deprotection gave the tris-HOPO 10 , an interesting target as it has both cationic and anionic binding sites. The HOPO hydroxylamine linker 11 was shown to be especially valuable as its coupling with carboxylic acids proceeds with the concomitant generation of an additional hydroxamate ligand moiety in the framework. The utility of this linker was shown by the preparation of two mixed HOPO-hydroxamate chelators, 16 and 19 , based on the structure of desferrioxamine, a well-known trihydroxamate siderophore. [ABSTRACT FROM AUTHOR]

COVID-19 has posed serious challenges for informal carers living in the UK. This article examines some of the specific challenges facing carers and the resources they used to manage them throughout the first UK lockdown. We used a framework approach to analyse naturalistic, longitudinal data from 30 carers taking part in 96 of Mobilise's daily Virtual Cuppas between March and July 2020. We found that lack of information and social restrictions cumulatively impacted carers' sense of certainty, control and motivation. This took an emotional toll on the carers, leading to exhaustion and burden. However, carers quickly established new routines and used humour and self-care to actively manage their wellbeing. Carers received support but also provided it to those in need, including fellow members of the caregiving community, supporting an ecological approach to carer resilience. Our findings may be used to anticipate challenges and promote protective resilience resources in future lockdowns. [ABSTRACT FROM AUTHOR]

The article reports on a study which attempted to evaluate the overall frequency of MYc expression in a larger series of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and determine whether MYC rearrangements or gains/amplifications might influence MYc expression. Topics discussed include the uniform upregulation of MYc in the proliferation centers of CLL/SLL. The presence of MYc hyperdiploidy in a relatively low percentage of MYc-positive cells is mentioned.

Objectives: To explore how much additional information single nucleotide polymorphism (SNP) arrays provide and whether they could partially replace classical cytogenetics. Methods: Twenty-six lymphoid proliferations with available cytogenetic studies were analyzed with the Affymetrix Genome-Wide Human SNP Array 6.0 (Affymetrix, Santa Clara, CA). Results: Eleven of 26 cases demonstrated complete concordance between cytogenetics and SNP analysis, and 10 of 26 cases demonstrated partial concordance. Five discordant cases had copy number abnormalities (CNAs) with cytogenetics not identified with SNP arrays. While SNP analysis showed CNAs not apparent by cytogenetics in eight cases and helped clarify the karyotype in six cases, cytogenetics demonstrated CNAs not seen by SNP analysis in 15 cases as well as balanced translocations in 12 cases. Conclusions: The combination of cytogenetics and SNP analysis results in a higher overall yield in identifying numerical chromosomal abnormalities than either technique alone. [ABSTRACT FROM AUTHOR]

Objective: To determine whether recommending cognitive rest to athletes after a sport-related concussion affects time to symptom resolution. Methods: A retrospective cohort study was conducted of 184 patients who presented to a sports concussion clinic in an academic medical centre between 1 November 2007 and 31 July 2009. The effect of recommending cognitive rest on symptom duration (days) was measured after adjusting for age, gender, initial PCSS score, history of amnesia, history of loss of consciousness and number of previous concussions. Using multivariate logistic regression, independent predictors of prolonged symptoms were identified, defined as >30 days. Results: Of the 135 study patients with complete medical records, 85 (63%) had cognitive rest recommended. Of those, 79 (59%) had prolonged symptoms. In the multivariate analysis, only initial PCSS score was associated with the duration of concussion symptoms (adjusted odds ratio (AOR) = 1.03; 95% CI = 1.01-1.05). The recommendation for cognitive rest was not significantly associated with time to concussion symptom resolution (AOR = 0.5; 95% CI = 0.18-1.37). Conclusions: Given the limited evidence regarding the effects of cognitive rest on recovery from concussion, recommendations of prolonged periods of cognitive rest, particularly absences from school, should be approached cautiously. [ABSTRACT FROM AUTHOR]

This study examined articulatory error patterns and phonological process use in 25 preschool children with hearing loss enrolled in three Canadian auditory-verbal intervention programs, and compared their performance to a control group of 35 children with typical hearing based on the GFTA-2 and the KLPA-2. Significant differences were found in the performance of the two groups on both measures. However, 17 (68%) of children with hearing loss had a standard score at or above 85 on the KLPA-2 and 18 (72%) on the GFTA-2 at their most recent assessment. Children with hearing loss used more phonological processes at the 36, 48, and 60 month test ages than children with typical hearing; however, their phonological systems resembled those of their peers. Children using hearing aids performed better than children with cochlear implants on both measures. Rates of progress analyses indicated that 12 of 14 children for whom multiple assessments were available made at least 12 months of progress in speech skill development in a 22 month period. Implications for current perspectives on the speech development of children with hearing loss are discussed. [ABSTRACT FROM AUTHOR]

Prominences and cavities are ubiquitously observed together, but the physical link between these disparate structures has not been established. We address this issue by using dynamic emission in the extreme ultraviolet to probe the connections of these structures. The SDO/AIA observations show that the cavity exhibits excessive emission variability compared to the surrounding quiet-Sun streamer, particularly in the 171Å bandpass. We find that this dynamic emission takes the form of coherent loop-like brightening structures which emanate from the prominence into the central cavity. The geometry of these structures, dubbed prominence horns, generally mimics the curvature of the cavity boundary. We use a space-time statistical analysis of two cavities in multiple AIA bandpasses to constrain the energetic properties of 45 horns. In general, we find there is a positive correlation between the light curves of the horns in the 171Å and 193Å bandpasses; however, the 193Å emission is a factor of five weaker. There is also a strong correlation between structural changes to the prominence as viewed in the He ii 304Å bandpass and the enhanced 171Å emission. In that bandpass, the prominence appears to extend several megameters along the 171Å horn where we observe co-spatial, co-temporal 304Å and 171Å emission dynamics. We present these observations as evidence of the magnetic and energetic connection between the prominence and the cavity. Further modeling work is necessary to explain the physical source and consequences of these events, particularly in the context of the traditional paradigm: the cavity is underdense because it supplies mass to the overdense prominence. [ABSTRACT FROM AUTHOR]

Abstract: There is a push in electrophysiology experiments to record simultaneously from many channels (upwards of 64) over long time periods (many hours). Given the relatively high sampling rates (10–40kHz) and resolutions (12–24bits per sample), these experiments accumulate exorbitantly large amounts of data (e.g. 100GB per experiment), which can be very time-consuming to process. Here, we present an FPGA-based spike-sorting platform that can increase the speed of offline spike sorting by at least 25 times, effectively reducing the time required to sort data from long experiments from several hours to just a few minutes. We attempted to preserve the flexibility of software by implementing several different algorithms in the design, and by providing user control over parameters such as spike detection thresholds. The results of sorting a published benchmark dataset using this hardware tool are shown to be comparable to those using similar software tools. [Copyright &y& Elsevier]

The ability to bear witness is crucial for those forced migrants who seek asylum in Britain. Within the context of a wider "culture of disbelief", those others are often greeted with suspicion and are categorised as "bogus" asylum seekers if they cannot provide credible testimony in support of their application. Despite the importance of such narratives, testimonies and life-stories, asylum seekers are frequently silenced and rendered speechless within the public sphere. The aporia of bearing witness is dramatised in Kay Adshead's The Bogus Woman and Timbertake Wertenbaker's Credible Witness in order to reveal the hostile conditions in Britain and the impossibility of testifying to a "well-founded fear of persecution" in the process of seeking asylum. This article examines the ethics and politics of speaking and hearing life-stories following Jacques Derrida's ethical writings on hospitality, testimony, and witnessing. [ABSTRACT FROM AUTHOR]

Background Constitutive activation of STAT5 (by phosphorylation) has been identified in a number of malignancies, including acute myeloid leukemia ( AML). Objectives We investigated whether the level of phosphorylated STAT5 ( pSTAT5) expression correlates with clinical outcome in AML. Methods Adult patients with newly diagnosed AML receiving induction chemotherapy and with an available diagnostic bone marrow were evaluated. Results Forty-two percent of patients had pSTAT5 expression >0 on immunohistochemical analysis of fixed bone marrow core biopsies. In multivariable analyses, controlling for age, history of antecedent hematologic disorder, cytogenetic risk, and WBC at diagnosis, pSTAT5 expression was significantly associated with an increased risk of death ( HR 1.96, 95% CI 1.19-3.23, P = 0.008) and of relapse after achieving complete remission ( HR 2.31, 95% CI 1.16-4.63, P = 0.018). Conclusions Validation of pSTAT5's prognostic value requires additional study in a larger group of uniformly treated patients. However, our data suggests that targeting this signaling pathway in AML may improve the outcome of patients. [ABSTRACT FROM AUTHOR]

The article presents information on the privacy rights of the anonymous posters on the websites of newspapers with respect to the fundamental rights of a person's autonomy and freedom. It discusses the issue with reference to the First Amendment protection of the U.S. Constitution and subpoenas and also states the difference the difference between informational privacy and decisional privacy. It further discusses Freedom of Information and the protection of individuals regarding personal data and also the free movement of data under the U.S. law as well as the European law. Information on the use of online public information and their privacy is also presented.

Coronal cavities are voids in coronal emission often observed above high latitude filament channels. Sometimes, these cavities have areas of bright X-ray emission in their centers. In this study, we use data from the X-ray Telescope (XRT) on the Hinode satellite to examine the thermal emission properties of a cavity observed during 2008 July that contains bright X-ray emission in its center. Using ratios of XRT filters, we find evidence for elevated temperatures in the cavity center. The area of elevated temperature evolves from a ring-shaped structure at the beginning of the observation, to an elongated structure two days later, finally appearing as a compact round source lbur days after the initial observation. We use a morphological model to fit the cavity emission, and find that a uniform structure running through the cavity does not fit the observations well. Instead, the observations are reproduced by modeling several short cylindrical cavity "cores" with different parameters on different days. These changing core parameters may be due to some observed activity heating different parts of the cavity core at different times. We find that core temperatures of 1.75 MK, 1.7 MK, and 2.0 MK (for July 19, July 21, and July 23, respectively) in the model lead to structures that are consistent with the data, and that line-of-sight effects serve to lower the effective temperature derived from the filter ratio. [ABSTRACT FROM AUTHOR]

We present an overview of the data and models collected for the Whole Heliosphere Interval, an international campaign to study the three-dimensional solar-heliospheric-planetary connected system near solar minimum. The data and models correspond to solar Carrington Rotation 2068 (20 March - 16 April 2008) extending from below the solar photosphere, through interplanetary space, and down to Earth's mesosphere. Nearly 200 people participated in aspects of WHI studies, analyzing and interpreting data from nearly 100 instruments and models in order to elucidate the physics of fundamental heliophysical processes. The solar and inner heliospheric data showed structure consistent with the declining phase of the solar cycle. A closely spaced cluster of low-latitude active regions was responsible for an increased level of magnetic activity, while a highly warped current sheet dominated heliospheric structure. The geospace data revealed an unusually high level of activity, driven primarily by the periodic impingement of high-speed streams. The WHI studies traced the solar activity and structure into the heliosphere and geospace, and provided new insight into the nature of the interconnected heliophysical system near solar minimum. [ABSTRACT FROM AUTHOR]

Histone H4 acetylation was examined by immunohistochemistry in patients with acute lymphocytic leukaemia (ALL) in first relapse. Univariate and multivariate models identified correlates of complete remission (CR) and overall survival (OS). No variables were associated with achievement of CR. In multivariate analysis, weak histone H4 acetylation [Hazard Ratio (HR) 2·20, 95% confidence interval (CI) 0·93-5·23, P = 0·07], shorter interval from diagnosis to relapse (<9 vs. 9-24 vs. >24 months) (HR 1·82, 95% CI 1·20-2·75, P = 0·005), and central nervous system involvement (HR 3·43, 95% CI 1·31-8·99, P = 0·01) were independent poor prognostic factors for OS. These data provide a rationale for the use of histone deacetylase inhibitors in the treatment of relapsed ALL. [ABSTRACT FROM AUTHOR]

Abstract: The intramolecular cyclizations of oxazolidinones with carbanions adjacent to sulfones, sulfoxides, and phosphonates proceed in high yields to obtain functionalized γ and δ lactams. The chiral oxazolidinone precursors can be readily synthesized from commercial amino acids. The lactams from this study are useful synthetic intermediates, as demonstrated by the synthesis of a precursor for levetiracetam, an antiepileptic drug. [ABSTRACT FROM AUTHOR]

Abstract: The concurrent esterification and N-acetylation of amino acids has been studied with triethyl orthoacetate (TEOA) and triethyl orthoformate (TEOF). In a surprising finding, only 1equiv of TEOA in refluxing toluene was necessary to convert l-proline and l-phenylalanine into the corresponding N-acetyl ethyl esters in good yield. The same transformation using TEOF was not effective. Stereochemical outcome and stoichiometric studies as well as structural variation of the amino acids in this reaction provided unexpected mechanistic insight. [ABSTRACT FROM AUTHOR]

Background: Histone deacetylase (HDAC) inhibitors are a novel anti-tumor therapy. To determine whether HDAC inhibitors may be useful in the treatment of adult acute lymphoblastic leukemia (ALL), we examined the acetylation of histone H4 by immunohistochemistry in newly diagnosed ALL patients and evaluated the impact of acetylation on complete remission (CR) rate, relapse-free survival (RFS), and overall survival (OS). Methods: Patients ≥18 years of age and an available diagnostic bone marrow biopsy were evaluated. Cox proportional hazards analysis was used to identify univariate and multivariate correlates of CR, RFS, and OS. The variables histone H4 acetylation (positive or negative), white blood count, cytogenetic (CG) risk group (CALGB criteria), and age were used in multivariate analysis. Results: On multivariate analysis, histone acetylation was associated with a trend towards an improved OS (for all CG risk groups) (HR = 0.51, p = 0.09). In patients without poor risk CG, there was an impressive association between the presence of histone acetylation and an improved CR rate (OR 3.43, p = 0.035), RFS (HR 0.07, p = 0.005), and OS (HR 0.24, p = 0.007). This association remained statistically significant in multivariate analysis. Conclusions: These data provide a rationale for the design of novel regimens incorporating HDAC inhibitors in ALL. [ABSTRACT FROM AUTHOR]

The past three decades have seen police agencies move toward the adoption of community policing. However, since 9/11, the policing focus has appeared to shift toward homeland security. Whether this represents a shift to a new policing philosophy or a modification to an existing one is unclear. Are community policing and homeland security policing compatible? Or does the move toward homeland security policing signal the demise of community policing? This study investigates these questions with data from Virginia police chiefs. Results suggest that police chiefs with 4-year degrees, chiefs from smaller departments, and chiefs from departments with higher levels of community policing implementation are less likely to believe that the emphasis on community policing is waning. Furthermore, police chiefs with 4-year degrees and those from departments with higher levels of community policing implementation are more likely to see community policing and homeland security policing as complementary strategies. Implications of the findings and directions for future research are discussed. [ABSTRACT FROM AUTHOR]

Context.—Primary skull lesions are rare in the pediatric population. The differential diagnosis of these lesions is broad and includes both congenital and acquired lesions. Previous studies of skull lesions in the pediatric population suggest that dermoid/epidermoid tumors are the most common childhood skull tumors. Objective.—To review the clinicopathologic features of primary skull lesions identified within the pediatric population of an academic tertiary medical center. Design.—A retrospective review of surgical pathology reports during a 25-year period identified 19 primary skull lesions occurring in the pediatric population. Lesions were excluded if they were of known soft tissue or intracranial origin with secondary calvarial involvement, or if they represented a metastasis from a known primary malignancy. Results.—Nineteen primary skull lesions were identified in 11 male (58%) and 8 female (42%) patients, with a median age at diagnosis of 9.5 years. These lesions were usually benign and most commonly presented as a painless mass (n = 8). The lesions were located in the occipital bone (n = 7), frontal bone (n = 5), parietal bone (n = 2), and temporal bone (n = 1). Diagnoses included epidermoid/dermoid cyst (n = 8), Langerhans cell histiocytosis (n = 6), intraosseous hemangioma (n = 2), osteoblastoma (n = 1), infantile myofibroma (n = 1), and fibroma (n = 1). Intracranial extension was identified in 1 case, and recurrence was found in only 2 cases. Conclusions.—Epidermoid/dermoid cysts and Langerhans cell histiocytosis are the most commonly encountered skull lesions in the pediatric population at our institution. Intracranial extension of these lesions is rare, and recurrence is uncommon following complete surgical resection. [ABSTRACT FROM AUTHOR]

Abstract: Nicotine is both a constitutive and induced defense in cultivated tobacco (Nicotiana tabacum). Nicotine is thought primarily to defend against above-ground herbivory; however, below-ground herbivores like the nematode Meloidogyne incognita can also damage plants. We evaluated the costs and benefits of constitutive nicotine production in four near-isogenic lines of N. tabacum differing in nicotine content. We exposed the four lines to levels of nematode infection below that found to induce nicotine synthesis, and measured nematode density and each line''s response to nematode presence. Nematode density did not differ among lines and was not related to leaf nicotine content in any of the lines, suggesting that constitutive nicotine content did not affect nematode survival or reproduction. Most measures of plant performance were unaffected by nematodes; however, nematode infection decreased flowering in the high nicotine line relative to the other lines. Lines with less constitutive nicotine did not incur similar costs, suggesting a tradeoff between nicotine production and tolerance of low levels of herbivory. A cost of nicotine production is also suggested by the fact that flowering was inversely correlated with leaf nicotine content in all four lines. Although nicotine conferred no resistance to nematodes, high nicotine content reduced the plant''s tolerance of low levels of nematode infection and was correlated with reduced flowering. In examining the costs and benefits of a constitutive plant defense, this work complements and extends previous research addressing the relationship between plant tolerance and induced defenses. [Copyright &y& Elsevier]

The article discusses the status of asylum seekers in Great Britain in the light of the degree of hospitality the country offers. The film "Dirty Pretty Things," by Stephen Fears illustrates the figure of an asylum seeker confronted by discrimination and hospitality issues in Great Britain. Several works by Stephen Fears which reflect class distinction of British culture are also included.

Nephrogenic fibrosing dermopathy is a recently recognized, scleromyxedema-like fibrosing skin condition that occurs in individuals with acute or chronic renal failure. Although the early descriptions of this disorder describe a purely cutaneous disease process, 2 recent autopsy reports have identified apparent multiorgan fibrosis with involvement of skeletal muscle, myocardium, lungs, kidneys, and testes. We describe a 23-year-old man with nephrogenic fibrosing dermopathy and significant fibrosis of the atrial myocardium and dura mater, which was identified at autopsy. Dural fibrosis is a previously undescribed systemic manifestation of nephrogenic fibrosing dermopathy. The literature is reviewed. [ABSTRACT FROM AUTHOR]

This article examines the accommodation of asylum seekers through Jacques Derrida's ethical writings on hospitality, generosity and parasitism. The differing hospitable spaces of the asylum and the hotel, and of the strange figures of the asylum seeker and the tourist, are discussed with reference to these discourses of "giving" and "taking", paralleling Derrida's opposition between unconditional hospitality and hospitality-as-economy. This "new racism" towards asylum seekers is thus located within the economic sphere, as asylum control is linked to the welfare state and to fears of strangers' parasiting the host nation. However, I argue that it is the nation-state that parasites asylum seekers both through their defining difference and their contribution to service economies. Ultimately then the asylum hotel does exist, as Stephen Frears' film, Dirty Pretty Things (2002), illustrates. [ABSTRACT FROM AUTHOR]

This article describes a floating support scheme, provided by a local housing association, which enables single vulnerable people to live independently in their own homes. The study aimed to explore the impact of the scheme from the perspectives of clients, floating support workers and representatives from health, social care and voluntary agencies. It was found that the majority of clients had long-term mental health problems and were supported by a range of professionals. Floating support was flexible in responding to individual needs. A number of themes of relevance to interprofessional working emerged from the data. These included: floating support as a community resource, links with other agencies and confidentiality, information sharing and risk management. Floating support workers worked closely with professionals from health, social care, voluntary and educational services. Although the scheme's contribution to client care was highly valued, a number of barriers to effective interagency working were evident. This study highlighted the need for discussion and presented a forum for developing an ongoing collaborative process to address the specific issues which emerged in focus group discussions. [ABSTRACT FROM AUTHOR]

To evaluate the output temperature of a dry heat fluid warmer at fluid rates typically used in small animal veterinary patients. Prospective in vitr o study. None. Ambient temperature lactated Ringer's (17.9-18.8 °C) was delivered via a dry heat fluid warmer. A temperature probe was used to measure fluid outflow temperature from the compatible giving set at 5, 10, 20, 50, 70, 80, 100, 200, 300, 400 and 500 mL hour–1. Outflow fluid temperature at plateau (two consecutive readings within 0.1 °C) was compared with baseline fluid temperature (fluid warmer turned off) to calculate temperature changes at each rate. Kruskal–Wallis test was used to compare changes in temperature and time to plateau temperature. Dunn's post hoc test was used to test for significant differences in temperature compared to 5 mL hour–1; p value < 0.05. Median plateau outflow temperature increased as fluid rate increased, with temperatures of 18.5, 18.6, 18.7, 18.8, 19.4, 19.4, 21.5, 25.3, 28.5, 30.7 and 32.6 °C, at flow rates of 5, 10, 20, 50, 70, 80, 100, 200, 300, 400 and 500 mL hour–1. Fluid rates > 100 mL hour–1 showed significant increases from baseline (p = 0.021) There was no difference in temperature change from baseline at fluid rates < 100 mL hour–1 (p > 0.05). Compared to plateau temperature at 5 mL hour-1, there was a statistical difference in plateau temperature above 100 mL hour–1 (p = 0.0207). Maximum outflow plateau temperature was 32.6 °C at 500 mL hour–1. A dry heat fluid warmer has significantly decreased efficacy at low fluid rates, with no statistically significant increase in fluid temperature at fluid rates below 100 mL hour–1 at the end of a compatible fluid line. Inline dry heat fluid warmers are ineffective at fluid rates below 100 mL hour–1. [ABSTRACT FROM AUTHOR]

Background: Deaths of people with intellectual disabilities are often unplanned for and poorly managed. Little is known about how to involve people with intellectual disabilities in end-of-life care planning. Aim: To explore the perspectives of people with intellectual disabilities, families, health and social care professionals and policy makers on end-of-life care planning within intellectual disability services. Design: A total of 11 focus groups and 1 semi-structured interview were analysed using qualitative framework and matrix analysis. The analysis was conducted inclusively with co-researchers with intellectual disabilities. Setting/participants: A total of 60 participants (14 people with intellectual disabilities, 9 family carers, 21 intellectual disability professionals, 8 healthcare professionals and 8 policy makers) from the UK. Results: There were differences in how end-of-life care planning was understood by stakeholder groups, covering four areas: funeral planning, illness planning, planning for living and talking about dying. This impacted when end-of-life care planning should happen and with whom. Participants agreed that end-of-life care planning was important, and most wanted to be involved, but in practice discussions were postponed. Barriers included issues with understanding, how or when to initiate the topic and a reluctance to talk about dying. Conclusions: To develop effective interventions and resources aiding end-of-life care planning with people with intellectual disabilities, clarity is needed around what is being planned for, with whom and when. Research and development are needed into supporting intellectual disability staff in end-of-life care planning conversations. Collaboration between intellectual disability staff and palliative care services may facilitate timely end-of-life care planning and thus optimal palliative end-of-life care. [ABSTRACT FROM AUTHOR]

Objectives VEXAS syndrome is an adult-onset autoinflammatory disease caused by a somatic pathogenic mutation in the UBA1 (ubiquitin-like modifier activating enzyme 1) gene. Patients present with rheumatologic manifestations and cytopenias and may have an increased predisposition to myelodysplastic syndrome (MDS) and plasma cell neoplasms. Prior studies have reported on the peripheral blood and bone marrow findings in patients with VEXAS syndrome. Due to the protean clinical presentation and lack of specificity of morphologic features (eg, vacuoles in early erythroid and granulocytic precursors), an optimal screening methodology to identify these patients in a timely fashion is desirable. Methods To further evaluate and describe the salient diagnostic morphologic features in VEXAS syndrome, we carried out a comprehensive study of the largest single-institution cohort to date. Diagnostic and follow-up bone marrow biopsy specimens from 52 male patients with molecularly identified VEXAS syndrome underwent central review. Results Cytopenias were common in all cases, primarily macrocytic anemia, monocytopenia, and thrombocytopenia. Bone marrow aspirate and biopsy were often hypercellular, with an increased myeloid/erythroid ratio, granulocytic hyperplasia with left shift, erythroid left shift, and megakaryocyte hyperplasia, which exhibited a range of striking morphologic findings. Distinctly vacuolated myeloid and erythroid precursors were seen in more than 95% of cases. Conclusions Our data reveal potential novel diagnostic features, such as a high incidence of monocytopenia and distinct patterns of atypical megakaryopoiesis, that appear different from dysmegakaryopoiesis typically associated with MDS. In our experience, those findings are suggestive of VEXAS, in the appropriate clinical context. [ABSTRACT FROM AUTHOR]

Discusses the biological significance and clinical relevance of ACTH precursors. Common causes of ACTH-dependent Cushing's syndrome; Regulation of ACTH precursor secretion; Synthesis of the precursor proopiomelanocortin gene.

This article discusses the use of camcorders in the classroom as a way to enhance the education experience. Computers, video and compact disks, camcorders, and satellite communication systems offer alternative systems of instruction to textbooks (Gilliom, Helgeson, and Zuga 1992). In addition, they may be used as substitutes for traditional classroom pencil-paper tests. Assessing teacher performance has often been problematic because the assessor and the teacher have different perspectives. Videotapes, however, offer congruent evidence on which to base assessments. We contend that documentation of teacher performance and skill attainment gathered in a technologically objective way is more precise than data gathered using traditional methods, and it facilitates authentic assessment. Camcorders are accessible, affordable, and usable by amateurs. Furthermore, they allow teachers to assess their pedagogical skills privately and independently. It is posited that data supplied by videotapes offer a more complete description of the naturalistic environment of the classroom than scripting or coding. Teachers who use this process can become more aware of their classroom behavior and can continue to develop as reflective practitioners.

Objectives: Peer support is rapidly being introduced into mental health services internationally, yet peer support interventions are often poorly described, limiting the usefulness of research in informing policy and practice. This paper reports the development of a peer support intervention that aims to improve outcomes of discharge from inpatient to community mental health care. People with experiential knowledge of using mental health services—peer workers and service user researchers—were involved in all stages of developing the intervention: generating intervention components; producing the intervention handbook; piloting the intervention. Results: Systematic review and expert panels, including our Lived Experience Advisory Panel, identified 66 candidate intervention components in five domains: Recruitment and Role Description of Peer Workers; Training for Peer Workers; Delivery of Peer Support; Supervision and Support for Peer Workers; Organisation and Team. A series of Local Advisory Groups were used to prioritise components and explore implementation issues using consensus methods, refining an intervention blueprint. A peer support handbook and peer worker training programme were produced by the study team and piloted in two study sites. Feedback workshops were held with peer workers and their supervisors to produce a final handbook and training programme. The ENRICH trial is registered with the ISRCTN clinical trial register, number ISRCTN 10043328, and was overseen by an independent steering committee and a data monitoring committee. [ABSTRACT FROM AUTHOR]

In this study, we present the magnetic configuration of an erupting pseudostreamer observed on 2015 April 19, on the southwest limb of the Sun, with a prominence cavity embedded inside. The eruption resulted in a partial halo coronal mass ejection. The prominence eruption begins with a slow rise and then evolves to a fast-rise phase. We analyze this erupting pseudostreamer using the flux-rope insertion method and magnetofrictional relaxation to establish a sequence of plausible out-of-equilibrium magnetic configurations. This approach allows the direct incorporation of observations of structures seen in the corona (filament and cavity) to appropriately model the pseudostreamer based on SDO/HMI line-of-sight photospheric magnetograms. We also perform a topological analysis in order to determine the location of quasiseparatrix layers (QSLs) in the models, producing Q-maps to examine how the QSL locations progress in the higher iterations. We found that the axial flux in our best-fit unstable model was a factor of 20 times higher than we found in our marginally stable case. We computed the average magnetic field strength of the prominence and found that the unstable model exhibits twice the average field strength of the stable model. The eruption height from our modeling matches very well with the prominence eruption height measured from the AIA observation. The Q-maps derived from the model reproduce structures observed in LASCO/C2. Thus, the modeling and topological analysis results are fully consistent with the observed morphological features, implying that we have captured the large magnetic structure of the erupting filament in our magnetofrictional simulation. [ABSTRACT FROM AUTHOR]

Although the solar wind flows primarily outward from the Sun to interplanetary space, there are times when small-scale plasma inflows are observed. Inward-propagating density fluctuations in polar coronal holes were detected by the COR2 coronagraph on board the STEREO-A spacecraft at heliocentric distances of 7–12 solar radii, and these fluctuations appear to undergo substantial deceleration as they move closer to the Sun. Models of linear magnetohydrodynamic waves have not been able to explain these deceleration patterns, so they have been interpreted more recently as jets from coronal sites of magnetic reconnection. In this paper, we develop a range of dynamical models of discrete plasma parcels with the goal of better understanding the observed deceleration trend. We found that parcels with a constant mass do not behave like the observed flows, and neither do parcels undergoing ablative mass loss. However, parcels that accrete mass in a snowplow-like fashion can become decelerated as observed. We also extrapolated OMNI in situ data down to the so-called Alfvén surface and found that the initial launch point for the observed parcels may often be above this critical radius. In other words, in order for the parcels to flow back down to the Sun, their initial speeds are probably somewhat nonlinear (i.e., supra-Alfvénic), and thus the parcels may be associated with structures such as shocks, jets, or shear instabilities. [ABSTRACT FROM AUTHOR]

Magnetic fields suspend the relatively cool material of solar prominences in an otherwise hot corona. A comprehensive understanding of solar prominences ultimately requires complex and dynamic models, constrained and validated by observations spanning the solar atmosphere. We obtain the core of this understanding from observations that give us information about the structure of the “magnetic skeleton” that supports and surrounds the prominence. Energetically-sophisticated magnetohydrodynamic simulations then add flesh and blood to the skeleton, demonstrating how a thermally varying plasma may pulse through to form the prominence, and how the plasma and magnetic fields dynamically interact. [ABSTRACT FROM AUTHOR]