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6. Genomic surveillance of Canadian airport wastewater samples allows early detection of emerging SARS-CoV-2 lineages

Author

Overton, Alyssa K., Knapp, Jennifer J., Lawal, Opeyemi U., Gibson, Richard, Fedynak, Anastasia A., Adebiyi, Adebowale I., Maxwell, Brittany, Cheng, Lydia, Bee, Carina, Qasim, Asim, Atanas, Kyle, Payne, Mark, Stuart, Rebecca, Fleury, Manon D., Knox, Natalie C., Nash, Delaney, Hungwe, Yemurayi C., Prasla, Samran R., Ho, Hannifer, Agboola, Simininuoluwa O., Kwon, Su-Hyun, Naik, Shiv, Parreira, Valeria R., Rizvi, Fozia, Precious, Melinda J., Thomas, Steven, Zambrano, Marcos, Fang, Vixey, Gilliland, Elaine, Varia, Monali, Horn, Maureen, Landgraff, Chrystal, Arts, Eric J., Goodridge, Lawrence, Becker, Devan, and Charles, Trevor C.

Published
2024
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10. Risk of COVID-19 after natural infection or vaccination

Author

Rick, Anne-Marie, Laurens, Matthew B, Huang, Ying, Yu, Chenchen, Martin, Thomas CS, Rodriguez, Carina A, Rostad, Christina A, Maboa, Rebone M, Baden, Lindsey R, Sahly, Hana M El, Grinsztejn, Beatriz, Gray, Glenda E, Gay, Cynthia L, Gilbert, Peter B, Janes, Holly E, Kublin, James G, Huang, Yunda, Leav, Brett, Hirsch, Ian, Struyf, Frank, Dunkle, Lisa M, Neuzil, Kathleen M, Corey, Lawrence, Goepfert, Paul A, Walsh, Stephen R, Follmann, Dean, Kotloff, Karen L, Adams, Atoya, Miller, Eric, Rankin, Bruce G, Shinn, Steven, Nash, Marshall, Green, Sinikka L, Jacobsen, Colleen, Krishnankutty, Jayasree, Phungwayo, Sikhongi, Glover, Richard M, Slechta, Stacy, Holdeman, Troy, Hartvickson, Robyn, Grant, Amber, Poling, Terry L, Klein, Terry D, Klein, Thomas C, Klein, Tracy R, Smith, William B, Gibson, Richard L, Winbigler, Jennifer, Parker, Elizabeth, Wijewardane, Priyantha N, Bravo, Eric, Thessing, Jeffrey, Maxwell, Michelle, Horn, Amanda, Healy, Catherine Mary, Akamine, Christine, Chu, Laurence, Chouteau, R Michelle, Cotugno, Michael J, Bauer, George H, Hachigian, Greg, Oshita, Masaru, Cancilla, Michael, Kiersey, Kristen, Seger, William, Antwi, Mohammed, Green, Allison, Kim, Anthony, Desjardins, Michael, Johnson, Jennifer A, Sherman, Amy, Borger, Judith, Saleem, Nafisa, Solis, Joel, Medina, Martha Carmen, Keating, Westly, Garcia, Edgar, Bueno, Cynthia, Segall, Nathan, Denham, Douglas S, Weiss, Thomas, Avworo, Ayoade, Hedges, Parke, Strout, Cynthia Becher, Santiago, Rica, Davis, Yvonne, Howenstine, Patty, Bondell, Alison, Marks, Kristin, Wang, Tina, Wilkin, Timothy, Vogler, Mary, Johnston, Carrie, Andrasik, Michele P, Andriesen, Jessica G, Broder, Gail, Eaton, Niles, Gelderblom, Huub G, and McClennen, Rachael

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Vaccine Related, Biotechnology, Prevention, Clinical Trials and Supportive Activities, Immunization, Clinical Research, Emerging Infectious Diseases, Infectious Diseases, Coronaviruses, 6.1 Pharmaceuticals, 3.4 Vaccines, Infection, Good Health and Well Being, Humans, COVID-19, COVID-19 Vaccines, Pandemics, SARS-CoV-2, United States, Vaccination, Natural infection, Hybrid immunity, NIAID-funded COVID-19 Prevention Network, natural infection, hybrid immunity, vaccination, Public Health and Health Services, Clinical sciences, Epidemiology
Abstract

BackgroundWhile vaccines have established utility against COVID-19, phase 3 efficacy studies have generally not comprehensively evaluated protection provided by previous infection or hybrid immunity (previous infection plus vaccination). Individual patient data from US government-supported harmonized vaccine trials provide an unprecedented sample population to address this issue. We characterized the protective efficacy of previous SARS-CoV-2 infection and hybrid immunity against COVID-19 early in the pandemic over three-to six-month follow-up and compared with vaccine-associated protection.MethodsIn this post-hoc cross-protocol analysis of the Moderna, AstraZeneca, Janssen, and Novavax COVID-19 vaccine clinical trials, we allocated participants into four groups based on previous-infection status at enrolment and treatment: no previous infection/placebo; previous infection/placebo; no previous infection/vaccine; and previous infection/vaccine. The main outcome was RT-PCR-confirmed COVID-19 >7-15 days (per original protocols) after final study injection. We calculated crude and adjusted efficacy measures.FindingsPrevious infection/placebo participants had a 92% decreased risk of future COVID-19 compared to no previous infection/placebo participants (overall hazard ratio [HR] ratio: 0.08; 95% CI: 0.05-0.13). Among single-dose Janssen participants, hybrid immunity conferred greater protection than vaccine alone (HR: 0.03; 95% CI: 0.01-0.10). Too few infections were observed to draw statistical inferences comparing hybrid immunity to vaccine alone for other trials. Vaccination, previous infection, and hybrid immunity all provided near-complete protection against severe disease.InterpretationPrevious infection, any hybrid immunity, and two-dose vaccination all provided substantial protection against symptomatic and severe COVID-19 through the early Delta period. Thus, as a surrogate for natural infection, vaccination remains the safest approach to protection.FundingNational Institutes of Health.

Published
2023

11. Lasing at a Stationary Inflection Point

Author

Herrero-Parareda, Albert, Furman, Nathaniel, Mealy, Tarek, Gibson, Richard, Bedford, Robert, Vitebskiy, Ilya, and Capolino, Filippo

Subjects
Physics - Optics
Abstract

The concept of lasers based on the frozen mode regime in active periodic optical waveguides with a 3rd-order exceptional point of degeneracy (EPD) is advanced. The frozen mode regime in a lossless and gainless waveguide is associated with a stationary inflection point (SIP) in the Bloch dispersion relation, where three Bloch eigenmodes coalesce forming the frozen mode. As a practical example, we consider an asymmetric serpentine optical waveguide (ASOW). An ASOW operating near the SIP frequency displays a large group delay of a non-resonant nature that scales as the cube of the waveguide length, leading to a strong gain enhancement when active material is included. Therefore, a laser operating in the close vicinity of an SIP has a gain threshold that scales as a negative cube of the waveguide length. We determine that this scaling law is maintained in the presence of small distributed losses, such as radiation associated with waveguide bends and roughness. In addition, we show that although gain causes a distortion in the modes coalescing at the SIP, the properties of the frozen mode are relatively resistant to such small perturbations and we still observe a large degree of exceptional degeneracy for gain values that bring the system above threshold. Finally, our study also reveals that lasing near an SIP is favored over lasing near a photonic band edge located in close proximity to the SIP. In particular, we observe that an SIP-induced lasing in an ASOW displays lower gain threshold compared to lasing near the photonic regular band edge (RBE), even though the SIP resonance has a lower quality factor than the RBE resonance.

Published
2022
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12. Language Machinery

Author

Gibson, Richard Hughes

Subjects
Scientific American (Periodical), Humanities, Social sciences
Abstract

GENERATIVE ARTIFICIAL INTELLIGENCE IS a headspace and a technology--as much an event playing out in our minds as it is a material reality emerging at our fingertips. Fast and fluent, [...]

Published
2023

14. Realism Confronts Utopia

Author

Gibson, Richard Hughes

Subjects
Wonder Confronts Certainty: Russian Writers on the Timeless Questions and Why Their Answers Matter (Critical work) -- Morson, Gary Saul, Books -- Book reviews, Humanities, Social sciences
Abstract

Realism Confronts Utopia Wonder Confronts Certainty: Russian Writers on the Timeless Questions and Why Their Answers Matter Gary Saul Morson Cambridge, MA: Harvard University Press, 2023. Announcing Aleksandr Solzhenitsyn's selection [...]

Published
2023

17. Body Integrity Identity Disorder and cyborgs : an exploration of the ethics of elective amputation and enhancement technologies

Author

Gibson, Richard, Brazier, Margaret, and Holm, Soren

Subjects
Body Integrity Identity Disorder, Disability, Canguilhem, Jurisprudence, Bioethics, Neuroprosthetics, BIID, Amputation, Harm
Abstract

The question of whether healthy limb amputation is an ethically and legally viable treatment option for those suffering from Body Integrity Identity Disorder (BIID) has received a modicum of attention and attracted a significant amount of controversy within both the bioethical community and beyond. In this thesis, I examine this question, taking as a foundational position that merely because the desire for healthy limb amputation is unusual, this is not ipso facto symptomatic of a catastrophic impairment to one's capacity to make healthcare decisions. I then explore the plethora of arguments employed by opponents and proponents of such operations from both a philosophical and jurisprudential approach. Following this, a justification for the narrowing of this thesis' focus will be provided. Then, in my thesis articles, I take a normativist approach to the phenomenon of disability. I question whether the harms associated with being disabled are necessarily intrinsic, and thus, challenge whether intentionally causing someone to become disabled is, by its nature, a harmful action and one which should be prohibited. In Paper One, I ask whether the practice of healthy limb amputation is antithetical to the goal of medical treatment, that being health's restoration and maintenance. Drawing on Georges Canguilhem's work, I refute a naturalistic dismissal of such operations and argue that by employing a nuanced model of health, therapeutic, healthy limb amputation can indeed conform to what one may consider the 'inner morality of medicine'. Paper Two explores the relationship between the ethical evaluation of healthy limb amputation and the supposed harm of causing someone to become disabled. Through surveying the question via a lens of disability studies, and expressly according to the Social Model of Disability, I challenge the prima facie harms assumed to be inherent in limb amputation. Taking this detachment of disability and impairment further, in Paper Three, I investigate the impact that neuroprosthetics will have on the ethical viability of healthy limb amputation for BIID. I explore how the development of sophisticated artificial limbs could dramatically impact the ethical debate around treatment for BIID, and especially, how arguments based on the harms of conferring disability on the previously non-disabled could lose their persuasive power. In my final paper, I turn to the legal consideration of healthy limb amputation. I detour from the typical, theoretical, legal defence from GBH for a surgeon facilitating such an operation, built upon the 'medical exception'. Instead, I explore the lack of ontological clarity regarding the concept of harm within English law. From here, I propose that with a more developed idea of what harm is, the act of therapeutic, healthy limb amputation may not be harmful, and thus, a surgeon's actions would not qualify them for a charge of GBH. Ultimately, this leads me to tentatively conclude that the practice of healthy limb amputation is a potentially ethically and legally viable treatment option for those with BIID. However, such a conclusion is only preliminary. A substantial amount of work still needs to be done regarding the disorder to take this conclusion from a cautious, circumstantial endorsement to a full-blown, unrepentant advocation.

Published
2021

19. Risk of COVID-19 after natural infection or vaccination

Author

Adams, Atoya, Miller, Eric, Rankin, Bruce G., Shinn, Steven, Nash, Marshall, Green, Sinikka L., Jacobsen, Colleen, Krishnankutty, Jayasree, Phungwayo, Sikhongi, Glover, Richard M., II, Slechta, Stacy, Holdeman, Troy, Hartvickson, Robyn, Grant, Amber, Poling, Terry L., Klein, Terry D., Klein, Thomas C., Klein, Tracy R., Smith, William B., Gibson, Richard L., Winbigler, Jennifer, Parker, Elizabeth, Wijewardane, Priyantha N., Bravo, Eric, Thessing, Jeffrey, Maxwell, Michelle, Horn, Amanda, Healy, Catherine Mary, Akamine, Christine, Chu, Laurence, Chouteau, R. Michelle, Cotugno, Michael J., Bauer, George H., Jr., Hachigian, Greg, Oshita, Masaru, Cancilla, Michael, Kiersey, Kristen, Seger, William, Antwi, Mohammed, Green, Allison, Kim, Anthony, Desjardins, Michael, Johnson, Jennifer A., Sherman, Amy, Walsh, Stephen R., Borger, Judith, Saleem, Nafisa, Solis, Joel, Medina, Martha Carmen, Keating, Westly, Garcia, Edgar, Bueno, Cynthia, Segall, Nathan, Denham, Douglas S., Weiss, Thomas, Avworo, Ayoade, Hedges, Parke, Strout, Cynthia Becher, Santiago, Rica, Davis, Yvonne, Howenstine, Patty, Bondell, Alison, Marks, Kristin, Wang, Tina, Wilkin, Timothy, Vogler, Mary, Johnston, Carrie, Andrasik, Michele P., Andriesen, Jessica G., Broder, Gail, Eaton, Niles, Gelderblom, Huub G., McClennen, Rachael, Michael, Nelson, Robb, Merlin, Sopher, Carrie, Miller, Vicki E., Santiago, Fredric, Gomez, Blanca, Valika, Insiya, Starr, Amy, Cantos, Valeria D., Kandiah, Sheetal, Rio, Carlos del, Rouphael, Nadine, Edupuganti, Srilatha, Anderson, Evan J., Camacho-Gonzalez, Andres, Kamidani, Satoshi, Teherani, Meghan, Diemert, David J., Malkin, Elissa, Siegel, Marc, Roberts, Afsoon, Simon, Gary, Balani, Bindu, Stephenson, Carolene, Sperber, Steven, Cicogna, Cristina, Zervos, Marcus J., Kilgore, Paul, Ramesh, Mayur, Herc, Erica, Zenlea, Kate, Burgher, Abram, Milliken, Ann M., Davis, Joseph D., Levy, Brendan, Kelman, Sandra, Doust, Matthew W., Sample, Denise, Erickson, Sandra, Christensen, Shane G., Matich, Christopher, Longe, James, Witbeck, John, Peterson, James T., Clark, Alexander, Kelty, Gerald, Pena-Renteria, Issac, Koren, Michael J., Bartilucci, Darlene, Patel, Alpa, Tran, Carolyn, Kennelly, Christina, Brownlee, Robert, Coleman, Jacob, Webster, Hala, Fierro, Carlos A., Leistner, Natalia, Thompson, Amy, Gonzalez, Celia, Jackson, Lisa A., Suyehira, Janice, Haber, Milton, Regalado, Maria M., Procasky, Veronica, Lutat, Alisha, Griffin, Carl P., Hollister, Ripley R., Brown, Jeremy, Ronk, Melody, Harper, Wayne L., Cohen, Lisa, Eckert, Lynn, Hong, Matthew, Rouhbakhsh, Rambod, Danford, Elizabeth, Johnson, John, Calderone, Richard, Khetan, Shishir K., Olanrewaju, Oyebisi, Zhai, Nan, Nieves, Kimberly, O'Brien, Allison, Bradley, Paul S., Lilienthal, Amanda, Callis, Jim, Brosz, Adam B., Clement, Andrea, West, Whitney, Friesen, Luke, Cramer, Paul, Eder, Frank S., Little, Ryan, Engler, Victoria, Rattenbury-Shaw, Heather, Ensz, David J., Oplinger, Allie, Essink, Brandon J., Meyer, Jay, Raiser, Frederick, III, Mueller, Kimberly, Vrbicky, Keith W., Harper, Charles, Nutsch, Chelsie, Lewis, Wendell, III, Laflan, Cathy, Whatley, Jordan L., Harrell, Nicole, Shannon, Amie, Rowell, Crystal, Dedon, Christopher, Makhene, Mamodikoe, Gottschlich, Gregory M., Harden, Kate, Gottschlich, Melissa, Smith, Mary, Powell, Richard, Kimmel, Murray A., Pinto, Simmy, Vachris, Timothy P., Hutchens, Mark, Daniels, Stephen, Wells, Margaret, Van Der Leden, Mimi, Jackson-Booth, Peta-Gay, Baron, Mira, Kane, Pamela, Seversen, Shannen, Kryvicky, Mara, Lord, Julia, Saleh, Jamshid, Miles, Matthew, Lupercio, Rafael, McGettigan, John W., Jr., Patton, Walter, Brakema, Riemke, Choquette, Karin, McGettigan, Jonlyn, Kirstein, Judith L., Bernard, Marcia, Manning, Mary Beth, Rothenberg, Joan, Briskin, Toby, Roadman, Denise, Tedder-Edwards, Sharita, Schwartz, Howard I., Mederos, Surisday, Swaminathan, Shobha, Nyaku, Amesika, Varughese, Tilly, DallaPiazza, Michelle, Frey, Sharon E., Graham, Irene, Abate, Getahun, Hoft, Daniel, Allen, Leland N., III, Edwards, Leslie A., Davis, William S., Jr., Mena, Jessica M., Kutner, Mark E., Caso, Jorge, Moran, Maria Hernandez, Carvajal, Marianela, Mendez, Janet, Wadsworth, Larkin T., III, Adams, Michael R., Iverson, Leslie, Newberg, Joseph L., Pearlman, Laura, Nugent, Paul J., Reynolds, Michele D., Bashour, Jennifer, Schmidt, Robert, Sheth, Neil P., Steil, Kenneth, Toma, Ramy J., Kirby, William, Folmar, Pink, Williams, Samantha, Pickrell, Paul, Mott, Stefanie, Linebarger, Carol Ann, Malbari, Hussain, Pampe, David, Fragoso, Veronica G., Holloway, Lisa, McKeown-Bragas, Cecilia, Becker, Teresa, Williams, Barton G., Jones, William H., Clark, Jesse L., Shoptaw, Steven, Vertucci, Michele, Hernandez, Will, Spector, Stephen A., Moodley, Amaran, Blumenthal, Jill, Stangl, Lisa, Deutsch, Karen, Mullane, Kathleen M., Pitrak, David, Nuss, Cheryl, Pi, Judy, Fichtenbaum, Carl, Powers-Fletcher, Margaret, Saemann, Michelle, Kohrs, Sharon, Campbell, Thomas B., Lauria, Andrew, Mancilla, Jose C., Dunlevy, Hillary, Novak, Richard M., Wendrow, Andrea, Borgetti, Scott, Ladner, Ben, Chrisley, Lisa, Young, Cheryl, Doblecki-Lewis, Susanne, Alcaide, Maria L., Gonzales-Zamora, Jose, Morris, Stephen, Wohl, David, Eron, Joseph, Jr., Frank, Ian, Dunbar, Debora, Metzger, David, Momplaisir, Florence, Martin, Judith, Hoberman, Alejandro, Shope, Timothy, Muniz, Gysella, Rupp, Richard, Stanford, Amber, Berman, Megan, Porterfield, Laura, Lewis, Michael, Ghadishah, Elham, Yusin, Joseph, Pham, Mai, Creech, Clarence B., II, Walker, Shannon, Rolsma, Stephanie, Samuels, Robert, Thomsen, Isaac, Kalams, Spyros A., Wilson, Greg, Lucksinger, Gregg H., Parks, Kevin, Israelsen, Ryan, Ostovar, Jaleh, Kelly, Kary, Overcash, Jeffrey S., Chu, Hanh, Lee, Kia, De La Cruz, Luis I., Clemons, Steve, Everette, Elizabeth, Studdard, Suzanna, Mohan, Gowdhami, Tyson, Stefanie, Peay, Alyssa-Kay, Johnson, Danyel, Feldman, Gregory J., Suen, May-Yin, Muenzner, Jacqueline, Boscia, Joseph, Siddiqui, Farhan, Sanders, John, Peacock, James, Nasim, Julio, Levin, Michael L., Hussey, Julie, Kulic, Marcy, McKenzie, Mark M., Deese, Teresa, Osmundsen, Erica, Sweet, Christy, Ebuh, Valentine M., Elnagar, Elwaleed, Ebuh, Georgette, Iwuala, Genevieve, Han-Conrad, Laurie J., Simmons, Todd, Tarakjian, Denis, Ackermann, Jeremy, Adams, Mark S., Alemán, José O., Al-Ibrahim, Mohamed S., Andes, David R., Andrews, Jeb, Arduino, Roberto C., Bäcker, Martín, Badillo, Diana, Bainbridge, Emma, Batteiger, Teresa A., Bazan, Jose A., Bedimo, Roger J., Benitez, Jorge A., Bennett, Annette R., Bernstein, David I., Bialobok, Kristin, Boas, Rebecca, Brady, Judith, Brown, Cynthia, Bunce, Catherine A., Call, Robert S., Campbell, Wesley, Carmody, Ellie, Carpenter, Christopher, Carsons, Steven E., Castellon, Marvin, Castro, Mario, Catan, Hannah, Chang, Jennifer, Chebib, Mouna G., Chen, Corey M., Cheng, Margaret, Chow, Brian D.W., Ciambruschini, Annie, Connor, Joseph P., Conway, James H., Cooney, Maureen, Curlin, Marcel, De La Matta Rodriguez, Claudia, Dedon, Jon F., Degan, Emily, Dickey, Michelle, Dietz, Craig, Dong, Jennifer L., Dorcely, Brenda, Dube, Michael P., Dyer, Carmel B., Eckhardt, Benjamin, Ellerbeck, Edward, Ewers, Evan C., Falk, Amy, Feijoo, Brittany, Felsen, Uriel R., Fiel, Tom, Fitz-Patrick, David, Fogarty, Charles M., Ford, Stacy, Forero, Lina M., Formentini, Elizabeth, Franco-Vitteri, Doris, Frenck, Robert W., Jr., Gharib, Elie, Gharib, Suzanne, Rucker, Rola G., Goldenberg, James N., González, Luis H., Gray, Brett, Greene, Rusty, Grossberg, Robert M., Guanira-Carranza, Juan V., Guerreros Benavides, Alfredo Gilberto, Guillory, Clint C., Gunaratne, Shauna H., Halpert, David, Hamilton, Holli, Hartman, William R., Henderson, Sheryl L., Herati, Ramin, Guarin, Laura Hernandez, Hilder, Robin, Ho, Ken, Hojat, Leila, Hosek, Sybil G., Jacobson, Jeffrey M., Jay, Melanie, Johnson, Diane H., Jones, Kathleen S., Jones-López, Edward C., Justman, Jessica E., Kahney, Scott, Katz, Lois, Katz, Melinda, Kaul, Daniel, Keefer, Michael C., Kennedy, Ashley, Knishinsky, Jennifer, Kogelman, Laura, Koletar, Susan L., Kottkamp, Angelica, Laguio-Vila, Maryrose, Landovitz, Raphael J., Lee, Jessica L., Liu, Albert, Llerena Zegarra, Eneyda Giuvanela, Lok, Anna S., Lovell, James, Lubelchek, Ronald, Lucaj, John, Luckasen, Gary, Luetkemeyer, Annie, Lugogo, Njira Lucia, Maenza, Janine, Malvestutto, Carlos, Mauri, Monica, Maves, Ryan C., Mayer, Kenneth H., McCartney, Michael J., McCort, Margaret E., McElrath, M. Juliana, McNairy, Meredith, Merino, Fernando L., Meyerowitz, Eric A., Mitchell, Carol L., Monaco, Cynthia L., Muhammad, Sauda, Muñoz-Gómez, Sigridh, Munsiff, Sonal, Nee, Paul, Nollen, Nicole L., Noor, Asif, Lagos, Claudio Nuñez, Okulicz, Jason F., Oliver, Patrick A., Ortega, Jessica, Palmer, Steven, Parameswaran, Lalitha, Parikh, Purvi, Parker, Susan, Parungao, Reza, Pavie, Juana R., Madan, Rebecca P., Peralta, Henry, Petts, Jennifer, Pierce, Kristen K., Pretell Alva, E. Javier, Purpura, Lawrence J., Raabe, Vanessa, Recuenco, Sergio E., Richards, Tamara, Riddler, Sharon A., Rizzardi, Barbara, Rokser, Rachel, Rolle, Charlotte-Paige, Rosen, Adam, Rosen, Jeffrey, Freese, Lena R., Santolaya, María E., Schipani, Linda M., Schwartz, Adam, Schwasinger-Schmidt, Tiffany, Scott, Hyman, Sha, Beverly E., Shankaran, Shivanjali, Shapiro, Adrienne E., Sharp, Stephan C., Shopsin, Bo, Sims, Matthew D., Skipper, Stephanie, Smith, Derek M., Smith, Michael J., Sobhanie, M. Mahdee, Sovic, Brit, Sterling, Stephanie, Striker, Robert, Tafur Bances, Karla Beatriz, Talaat, Kawsar R., Tavel, Edward M., Jr., Tieu, Hong V., Tomaszewski, Christian, Tomlinson, Ryan, Torres, Juan P., Torres, Julian A., Treanor, John J., Tukuru, Sade, Ulrich, Robert J., Utz, Gregory C., Viar, Veronica, Viau Colindres, Roberto A., Walsh, Edward E., Walsh, Mary C., Walter, Emmanuel B., Weidler, Jessica L., Wu, Yi H., Yang, Kinara S., Yrivarren Giorza, Juan Luis, Zemanek, Arthur L., Zhang, Kevin, Zingman, Barry S., Gorman, Richard, Paez, Carmen A., Swann, Edith, Takuva, Simbarashe G., Greninger, Alex, Roychoudhury, Pavitra, Coombs, Robert W., Jerome, Keith R., Castellino, Flora, Tong, Xiaomi, Pavetto, Corrina, Gipson, Teletha, Tong, Tina, Lee, Marina, Zhou, James, Fay, Michael, McQuarrie, Kelly, Nnadi, Chimeremma, Sogbetun, Obiageli, Ahmad, Nina, De Proost, Ian, Hoseyni, Cyrus, Coplan, Paul, Khan, Najat, Ronco, Peter, Furey, Dawn, Meck, Jodi, Vingerhoets, Johan, Brandenburg, Boerries, Custers, Jerome, Hendriks, Jenny, Juraszek, Jarek, Marit de Groot, Anne, Van Roey, Griet, Heerwegh, Dirk, Van Dromme, Ilse, Méndez Galván, Jorge F., Carrascal, Monica B., Duran, Adriana Sordo, Sanchez Guerrero, Laura Ruy, Gómora Madrid, Martha Cecilia, Barrat Hernández, Alejandro Quintín, Guizar, Sharzhaad Molina, González Estrada, Denisse Alejandra, Martínez Pérez, Silvano Omar, Zárate Hinojosa, Zindy Yazmín, Ruiz-Palacios, Guillermo Miguel, Cruz-Valdez, Aurelio, Pacheco-Flores, Janeth, Lara, Anyela, Díaz-Miralrio, Secia, Reyes Fentanes, María José, Olmos Vega, Jocelyn Zuleica, Méndez, Daniela Pineda, Martínez, Karina Cano, Alvarez León, Winniberg Stephany, Ruiz Herrera, Vida Veronica, Vázquez Saldaña, Eduardo Gabriel, Camacho Choza, Laura Julia, Vega Orozco, Karen Sofia, Ortega Domínguez, Sandra Janeth, Chacón, Jorge A., Rivera, Juan J., Cutz, Erika A., Ortegón, Maricruz E., Rivera, María I., Browder, David, Burch, Cortney, Moye, Terri, Bondy, Paul, Browder, Lesley, Manning, Rickey D., Hurst, James W., Sturgeon, Rodney E., Wakefield, Paul H., Kirby, John A., Andersen, James, Fearon, Szheckera, Negron, Rosa, Medina, Amy, Hill, John M., Rajasekhar, Vivek, Williams, Hayes, Cade, LaShondra, Fouts, Rhodna, Moya, Connie, Anderson, Corey G., Devine, Naomi, Ramsey, James, Perez, Ashley, Tatelbaum, David, Jacobs, Michael, Menasche, Kathleen, Mirkil, Vincent, Winkle, Peter J., Haggag, Amina Z., Haynes, Michelle, Villegas, Marysol, Raja, Sabina, Riesenberg, Robert, Plavin, Stanford, Lerman, Mark, Woodside, Leana, Johnson, Maria, Healy, C. Mary, Whitaker, Jennifer A., Keitel, Wendy A., Atmar, Robert L., Horwith, Gary, Mason, Robin, Johnson, Lisa, Dora, Tambra, Murray, Deborah, Ledbetter, Logan, Ewing, Beverly, Stephenson, Kathryn E., Tan, Chen S., Zash, Rebecca, Ansel, Jessica L., Jaegle, Kate, Guiney, Caitlin J., Henderson, Jeffrey A., O'Leary, Marcia, Enright, Kendra, Kessler, Jill, Ducheneaux, Pete, Inniss, Asha, Brandon, Donald M., Davis, William B., Lawler, Daniel T., Oppong, Yaa D., Starr, Ryan P., Syndergaard, Scott N., Shelly, Rozeli, Majumder, Mashrur Islam, Sugimoto, Danny, Dugas, Jeffrey, Sr., Rijos, Dolores, Shelton, Sandra, Hong, Stephan, Schwartz, Howard, Sanchez-Crespo, Nelia, Schwartz, Jennifer, Piedra, Terry, Corral, Barbara, Medina, Carmen, Dever, Michael E., Shah, Mitul, Delgado, Michael, Scott, Tameika, Usdan, Lisa S., McGill, Lora J., Arnold, Valerie K., Scatamacchia, Carolyn, Anthony, Codi M., Merchant, Rajan, Yoon, Anelgine C., Hill, Janet, Ng-Price, Lucy, Thompson-Seim, Teri, Ackerman, Ronald, Ackerman, Jamie, Aristy, Florida, Ketter, Nzeera, Finley, Jon, Stull, Mildred, Murray, Monica, Rizvi, Zainab, Guerrero, Sonia, Paliwal, Yogesh K., Paliwal, Amit, Gordon, Sarah, Gordon, Bryan, Montano-Pereira, Cynthia, Galloway, Christopher, Montros, Candice, Aleman, Lily, Shairi, Samira, Van Ever, Wesley, Freeman, George H., Harmon, Esther L., Cross, Marshall A., Sales, Kacie, Gular, Catherine Q., Hepburn, Matthew, Alderson, Nathan, Harshell, Shana, Mahgoub, Siham, Maxwell, Celia, Mellman, Thomas, Thompson, Karl M., Wortman, Glenn, Kingsley, Jeff, Pixler, April, Curry, LaKondria, Afework, Sarah, Swanson, Austin, Jacqmein, Jeffry, Bowers, Maggie, Robison, Dawn, Mosteller, Victoria, Garvey, Janet, Easley, Mary, Kurnat, Rebecca J., Cornelison, Raymond, Gower, Shanda, Schnitz, William, Heinzig-Cartwright, Destiny S., Lewis, Derek, Newton, Fred E., Duhart, Aeiress, Watkins, Breanz, Ball, Brandy, York, Jill, Pickle, Shelby, Musante, David B., Silver, William P., Belhorn, Linda R., Viens, Nicholas A., Dellaero, David, Patel, Priti, Lisec, Kendra, Safirstein, Beth, Zapata, Luz, Gonzalez, Lazaro, Quevedo, Evelyn, Irani, Farah, Grillo, Joseph, Potts, Amy, White, Julie, Flume, Patrick, Headden, Gary, Taylor, Brandie, Warden, Ashley, Chamberlain, Amy, Jeanfreau, Robert, Jeanfreau, Susan, Matherne, Paul G., Caldwell, Amy, Stahl, Jessica, Vowell, Mandy, Newhouse, Lauren, Berthaud, Vladimir, Takizala, Zudi-Mwak, Beninati, Genevieve, Snell, Kimberly, Baker, Sherrie, Walker, James, Harrison, Tavane, Miller, Meagan, Otto, Janet, Gray, Roni, Wilson, Christine, Nemecek, Tiffany, Harrington, Hannah, Eppenbach, Sally, Lewis, Wendell, Bourgeois, Tana, Folsom, Lyndsea, Holt, Gregory, Mirsaeidi, Mehdi, Calderon, Rafael, Lichtenberger, Paola, Quintero, Jalima, Martinez, Becky, Immergluck, Lilly, Johnson, Erica, Chan, Austin, Fas, Norberto, Thomas-Seaton, LaTeshia, Khizer, Saadia, Staben, Jonathan, Beresnev, Tatiana, Jahromi, Maryam, Marovich, Mary A., Hutter, Julia, Nason, Martha, Ledgerwood, Julie, Mascola, John, Leibowitz, Mark, Morales, Fernanda, Delgado, Mike, Sanchez, Rosario, Vega, Norma, Áñez, Germán, Albert, Gary, Coston, Erin, Desai, Chinar, Dunbar, Haoua, Eickhoff, Mark, Garcia, Jenina, Kautz, Margaret, Lee, Angela, Lewis, Maggie, McGarry, Alice, McKnight, Irene, Nelson, Joy, Newingham, Patrick, Price-Abbott, Patty, Reed, Patty, Vegas, Diana, Wilkinson, Bethanie, Smith, Katherine, Woo, Wayne, Cho, Iksung, Glenn, Gregory M., Dubovsky, Filip, Fried, David L., Haughey, Lynne A., Stanton, Ariana C., Rameaka, Lisa Stevens, Rosenberg, David, Tomatsu, Lee, Gonzalez, Viviana, Manalo, Millie, Grunstra, Bernard, Quinn, Donald, Claybrook, Phillip, Olds, Shelby, Dye, Amy, Cannon, Kevin D., Chadwick, Mesha M., Jordan, Bailey, Hussey, Morgan, Nevarez, Hannah, Kelley, Colleen F., Chung, Michael, Moran, Caitlin, Rebolledo, Paulina, Bacher, Christina, Barranco-Santana, Elizabeth, Rodriguez, Jessica, Mendoza, Rafael, Ruperto, Karen, Olivieri, Odette, Ocaña, Enrique, Wylie, Paul E., Henderson, Renea, Jenson, Natasa, Yang, Fan, Kelley, Amy, Finkelstein, Kenneth, Beckmann, David, Hutchins, Tanya, Escallon, Sebastian Garcia, Johnson, Kristen, Sligh, Teresa S., Desai, Parul, Huynh, Vincent, Lopez, Carlos, Mendoza, Erika, Adelglass, Jeffrey, Naifeh, Jerome G., Kucera, Kristine J., Chughtai, Waseem, Jaffer, Shireen H., Davis, Matthew G., Foley, Jennifer, Burgett, Michelle L., Shlotzhauer, Tammi L., Ingalsbe-Geno, Sarah M., Duncanson, Daniel, Kush, Kelly, Nesbitt, Lori, Sonnier, Cora, McCarter, Jennifer, Butcher, Michael B., Fry, James, Percy, Donna, Freudemann, Karen, Gebhardt, Bruce C., Mangu, Padma N., Schroeck, Debra B., Davit, Rajesh K., Hennekes, Gayle D., Luft, Benjamin J., Carr, Melissa, Nachman, Sharon, Pellecchia, Alison, Smith, Candace, Valenti, Bruno, Bermudez, Maria I., Peraita, Noris, Delgado, Ernesto, Arrazcaeta, Alicia, Ramirez, Natalie, Amador, Carmen, Marafioti, Horacio, Dang, Lyly, Clement, Lauren, Berry, Jennifer, Allaw, Mohammed, Geuss, Georgettea, Miles, Chelsea, Bittner, Zachary, Werne, Melody, Calinescu, Cornell, Rodman, Shannon, Rindt, Joshua, Cooksey, Erin, Harrison, Kristina, Cooper, Deanna, Horton, Manisha, Philyaw, Amanda, Jennings, William, Alvarado, Hilario, Baka, Michele, Regalado, Malina, Murray, Linda, Naguib, Sherif, Singletary, Justin, Richmond, Sha-Wanda, Omodele, Sarah, Oppenheim, Emily, Martinez, Reuben, Andriulis, Victoria, Singer, Leonard, Blevins, Jeanne, Thomas, Meagan, Hull, Christine, Pereira, Isabel, Rivero, Gina, Okonya, Tracy, Downing, Frances, Miller, Paulina, Rhee, Margaret, Stapleton, Katherine, Klein, Jeffrey, Hong, Rosamond, Swan, Suzanne, Wahlin, Tami, Bennett, Elizabeth, Salzl, Amy, Phan, Sharine, White, Jewel J., Occhino, Amanda, Paiano, Ruth, McLaughlin, Morgan, Swieboda, Elisa, Garcia-Fragoso, Veronica, Becerra, Maria G., White, Toni, Turley, Christine B., McWilliams, Andrew, Esinhart, Tiffany, Montoya, Natasha, Huskey, Shamika, Paul, Leena, Tashima, Karen, Johnson, Jennie, Neill, Marguerite, Sanchez, Martha, Rybak, Natasha, Mileno, Maria, Cohen, Stuart H., Ruiz, Monica, Boswell, Dean M., Robison, Elizabeth E., Reynolds, Trina L., Neumeister, Sonja, Zorrilla, Carmen D., Rivera, Juana, Ibarra, Jessica, García, Iris, Sierra, Dianca, Ramon, Wanda, Fiorillo, Suzanne, Pitotti, Rebecca, Anderson, Victoria R., Mancilla, Jose Castillo, Le, Nga, Winokur, Patricia L., Ince, Dilek, Hegmann, Theresa, Meier, Jeffrey, Stapleton, Jack, Stulken, Laura, McArthur, Monica, Berry, Andrea, Tapia, Milagritos, Hammershaimb, Elizabeth, Robinson, Toni, MacBryde, Rosa, Kline, Susan, Billings, Joanne L., Cavert, Winston, Forgosh, Les B., Schacker, Timothy W., Bold, Tyler D., Dandachi, Dima, Nelson, Taylor, Bran, Andres, Geiger, Grant, Naqvi, S. Hasan, Florescu, Diana F., Starlin, Richard, Kline, David, Zimmer, Andrea, Abbas, Anum, Wilson, Natasha, Eron, Joseph J., Sciaudone, Michael, Rosengren, A. Lina, Kizer, John S., Rutstein, Sarah E., Bruce, Elizabeth, Espinosa, Claudia, Sanders, Lisa J., Kim, Kami, Casey, Denise, Taylor, Barbara S., Patterson, Thomas, Pinilla, Ruth S., Bullock, Delia, Ponce, Philip, Patterson, Jan, McClelland, R. Scott, Lane, Dakotah C., Wald, Anna, James, Frank, Duke, Elizabeth, Hauge, Kirsten, Heimonen, Jessica, Goecker, Erin A., Huang, Yunda, Fong, Youyi, Kauffman, Carol, Linder, Kathleen, Nofz, Kimberly, McConnell, Andrew, Buynak, Robert J., Webb, Angella, Petty, Taryn, Andree, Stephanie, Sanchez, Erica, Mackey, Nolan, Baudelaire, Clarisse, Dzigiel, Sarah, Marquez, Adrienna, Quillin, Kim, King, Michelle, Abad, Vanessa, Knowles, Jennifer, Waters, Michael, Zepeda, Karla, Coslet, Jordan, Tovar, Dalia, Shaw, Marian E., Turner, Mark A., Huffine, Cory J., Huffine, Esther S., Ake, Julie A., Secord, Elizabeth, McGrath, Eric, Levy, Phillip, Stewart, Brittany, Cromer, Charnell, Walters, Ayanna, Ellsworth, Grant, Greene, Caroline, Galloway, Sarah, Kapadia, Shashi, DeHaan, Elliot, Wilson, Clint, Milligan, Jason, Raley, Danielle, Bocchini, Joseph, McClenathan, Bruce, Hussain, Mary, Lomasney, Evelyn, Hall, Evelyn, Lamberth, Sherry, Schmeck, Christy, Leathers, Vickie, Theodore, Deborah A., Branche, Angela R., Graciaa, Daniel S., Hatlen, Timothy J., Miller, Jacqueline, Sadoff, Jerald, Falsey, Ann R., Sobieszczyk, Magdalena E., Rick, Anne-Marie, Laurens, Matthew B., Huang, Ying, Yu, Chenchen, Martin, Thomas C.S., Rodriguez, Carina A., Rostad, Christina A., Maboa, Rebone M., Baden, Lindsey R., El Sahly, Hana M., Grinsztejn, Beatriz, Gray, Glenda E., Gay, Cynthia L., Gilbert, Peter B., Janes, Holly E., Kublin, James G., Leav, Brett, Hirsch, Ian, Struyf, Frank, Dunkle, Lisa M., Neuzil, Kathleen M., Corey, Lawrence, Goepfert, Paul A., Follmann, Dean, and Kotloff, Karen L.

Published
2023
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22. The Religious Revolution: The Birth of Modern Spirituality, 1848-1898

Author

Gibson, Richard Hughes

Subjects
The Religious Revolution: The Birth of Modern Spirituality, 1848-1898 (Nonfiction work) -- Green, Dominic, Books -- Book reviews, Humanities, Social sciences
Abstract

The Religious Revolution: The Birth of Modern Spirituality, 1848-1898 Dominic Green New York, NY: Farrar, Straus and Giroux, 2022. Having already recounted God's life through popular biographies of Jesus and [...]

Published
2022

25. Biochemical and biophysical characterisation of the quartromicin polyketide synthase

Author

Gibson, Richard

Subjects
540, QD Chemistry
Abstract

Quartromicin (QMN), derived from Amycolatopsis orientalis Q427-8, are a complex of novel antiviral antibiotics active against HSV-1, HIV and influenza. Their biosynthesis involves a type Ipolyketide synthase (PKS), proposed to implement a module skipping strategy that produces two different precursors (Figure 1). A series of Diels-Alderase reactions, followed by oxidation and glycosylation, leads to QMN biosynthesis. Determining how this module skipping mechanism works would greatly increase the understanding of how modules within PKSs can be relocated to facilitate PKS engineering. It was shown that module 5 (M5) can accept substrates from the upstream modules' acyl carrier protein (ACP) domains (M3 ACP and M4 ACP) and utilise malonyl-CoA to catalyse substrate extension. Substrate specificity did not appear to be a factor in maintaining pathway fidelity. M3 ACP was observed to have a quicker rate of acyl transfer to M5 than M4 ACP and stronger protein-protein interactions (KD: 1.3 v 4.0 μM). Removal of M3 ACP's C-terminal docking domain resulted in slower transfer and weakening of protein-protein interactions (KD: 2.6 μM). There was no significant change in rates of transfer or strength of interactions when the docking domain was omitted from M4 ACP. Sequence analysis of the docking domains highlighted the omission of a widely conserved negative residue from M4's ACP docking domain, perhaps explaining the reduced efficiency. A loss of antimicrobial and functionality was noted in M5 constructs lacking an AT-ACP linker region. Comparison with other spirotetronate PKS modules identified similar regions in ChlA6and KijS5, predicted to be remnants of KR domains. Creation of truncated constructs allowed the identification of an α-helix essential in module dimerisation and suggested a dimerization motif was located towards the C-terminal of the linker. Cryo-EM of M5 showed a large dimer interface between the KS domains of two modules and a second contact region, likely to be the aforementioned dimerisation motif.

Published
2018

26. THE CRITIC'S CRITIC

Author

Gibson, Richard Hughes

Subjects
Criticism -- Social aspects, Humanities, Social sciences
Abstract

George Steiner was called many things across his lengthy writing career--sage, pedant, philosopher, snob, the last great European intellectual, a 'mimic' staging a decades-long 'impression of the world's most learned [...]

Published
2021

28. SUPPLY CHAIN SUBLIME.

Author

Gibson, Richard Hughes

Subjects
SUPPLY chains, GLOBAL production networks, TECHNOLOGICAL innovations, INTERNATIONAL trade
Abstract

The article examines the evolution of supply chains, shifting from Adam Smith's early observations to modern reflections on their vast, complex nature. Topics discussed include the philosophical concept of the sublime in relation to supply chains, the growing intricacy of global production networks, and the impact of technological advancements on logistics and global commerce.

Published
2024

30. Genomic Surveillance of a Canadian Airport Wastewater Samples Allows Early Detection of Emerging SARS-CoV-2 Lineages

Author

Overton, Alyssa K., primary, Knapp, Jennifer J., additional, Lawal, Opeyemi U., additional, Gibson, Richard, additional, Fedynak, Anastasia A., additional, Adebiyi, Adebowale I., additional, Maxwell, Brittany, additional, Cheng, Lydia, additional, Bee, Carina, additional, Qasim, Asim, additional, Atanas, Kyle, additional, Payne, Mark, additional, Stuart, Rebecca, additional, Fleury, Manon D., additional, Knox, Natalie C., additional, Nash, Delaney, additional, Hungwe, Yemurayi C., additional, Prasla, Samran R., additional, Ho, Hannifer, additional, Agboola, Simininuoluwa O., additional, Kwon, Su-Hyun, additional, Naik, Shiv, additional, Parreira, Valeria R., additional, Rizvi, Fozia, additional, Precious, Melinda J., additional, Thomas, Steven, additional, Zambrano, Marcos, additional, Fang, Vixey, additional, Gilliand, Elaine, additional, Varia, Monali, additional, Horn, Maureen, additional, Landgraff, Chrystal, additional, Arts, Eric J., additional, Goodridge, Lawrence, additional, and Charles, Trevor C., additional

Published
2024
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31. Developing and Investigating a Nanovibration Intervention for the Prevention/Reversal of Bone Loss Following Spinal Cord Injury

Author

Williams, Jonathan A., primary, Campsie, Paul, additional, Gibson, Richard, additional, Johnson-Love, Olivia, additional, Werner, Anna S., additional, Sprott, Mark, additional, Meechan, Ryan, additional, Huesa, Carmen, additional, Windmill, James F.C., additional, Purcell, Mariel, additional, Coupaud, Sylvie, additional, Dalby, Matthew J., additional, Childs, Peter G., additional, Riddell, John S., additional, and Reid, Stuart, additional

Published
2024
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33. You've Been Hacked

Author

Gibson, Richard Hughes

Subjects
Computer crimes, Medical records, Health care industry, Health care industry, Computer crime, Humanities, Social sciences
Abstract

The Age of Surveillance Capitalism: The Fight for a Human Future at the New Frontier of Power Shoshana Zuboff New York, NY: PublicAffairs, 2019. Consider four news stories from the [...]

Published
2020

35. Regret Minimization in Non-Zero-Sum Games with Applications to Building Champion Multiplayer Computer Poker Agents

Author

Gibson, Richard

Subjects
Computer Science - Computer Science and Game Theory, Computer Science - Multiagent Systems, 68T37, 68T42, 91A06, 91A18, I.2.1
Abstract

In two-player zero-sum games, if both players minimize their average external regret, then the average of the strategy profiles converges to a Nash equilibrium. For n-player general-sum games, however, theoretical guarantees for regret minimization are less understood. Nonetheless, Counterfactual Regret Minimization (CFR), a popular regret minimization algorithm for extensive-form games, has generated winning three-player Texas Hold'em agents in the Annual Computer Poker Competition (ACPC). In this paper, we provide the first set of theoretical properties for regret minimization algorithms in non-zero-sum games by proving that solutions eliminate iterative strict domination. We formally define \emph{dominated actions} in extensive-form games, show that CFR avoids iteratively strictly dominated actions and strategies, and demonstrate that removing iteratively dominated actions is enough to win a mock tournament in a small poker game. In addition, for two-player non-zero-sum games, we bound the worst case performance and show that in practice, regret minimization can yield strategies very close to equilibrium. Our theoretical advancements lead us to a new modification of CFR for games with more than two players that is more efficient and may be used to generate stronger strategies than previously possible. Furthermore, we present a new three-player Texas Hold'em poker agent that was built using CFR and a novel game decomposition method. Our new agent wins the three-player events of the 2012 ACPC and defeats the winning three-player programs from previous competitions while requiring less resources to generate than the 2011 winner. Finally, we show that our CFR modification computes a strategy of equal quality to our new agent in a quarter of the time of standard CFR using half the memory.

Published
2013

38. No-Regret Learning in Extensive-Form Games with Imperfect Recall

Author

Lanctot, Marc, Gibson, Richard, Burch, Neil, Zinkevich, Martin, and Bowling, Michael

Subjects
Computer Science - Computer Science and Game Theory, Computer Science - Artificial Intelligence
Abstract

Counterfactual Regret Minimization (CFR) is an efficient no-regret learning algorithm for decision problems modeled as extensive games. CFR's regret bounds depend on the requirement of perfect recall: players always remember information that was revealed to them and the order in which it was revealed. In games without perfect recall, however, CFR's guarantees do not apply. In this paper, we present the first regret bound for CFR when applied to a general class of games with imperfect recall. In addition, we show that CFR applied to any abstraction belonging to our general class results in a regret bound not just for the abstract game, but for the full game as well. We verify our theory and show how imperfect recall can be used to trade a small increase in regret for a significant reduction in memory in three domains: die-roll poker, phantom tic-tac-toe, and Bluff., Comment: 21 pages, 4 figures, expanded version of article to appear in Proceedings of the Twenty-Ninth International Conference on Machine Learning

Published
2012

39. The Enlightenment: The Pursuit of Happiness, 1680-1790

Author

Gibson, Richard Hughes

Subjects
The Enlightenment: The Pursuit of Happiness, 1680-1790 (Nonfiction work) -- Robertson, Ritchie, Books -- Book reviews, Humanities, Social sciences
Abstract

The Enlightenment: The Pursuit of Happiness, 1680-1790 Ritchie Robertson New York, NY: Harper, 2021. What is happiness? Every era has entertained this question. Yet as Ritchie Robertson, Taylor Professor of [...]

Published
2021

43. Book review: Novel Beings: Regulatory Approaches for a Future of New Intelligent Life.

Author

Gibson, Richard B

Subjects
PAY equity, TECHNOLOGICAL innovations, WOMEN'S programs, INTELLECTUAL property
Abstract

The book "Novel Beings: Regulatory Approaches for a Future of New Intelligent Life" edited by David R. Lawrence and Sarah Morley examines the ethical and regulatory challenges presented by the development of morally significant artificial lifeforms. Divided into two parts, the book discusses the need for earlier regulation and the integration of ethics into the design process. It also explores the importance of government intervention and public opinion in shaping behaviors related to morally significant technologies. The book calls for a new regulatory approach to effectively manage the development and impact of novel beings. However, it lacks clarity in defining what exactly constitutes a novel being. [Extracted from the article]

Published
2024
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46. Treating COVID-19 Acute Severe Hypoxemic Respiratory Failure: First Case Report Utilizing Dexamethasone, Remdesivir, and Convalescent Plasma in Operation Inherent Resolve

Author

Gibson, Richard L., Sletten, Zachary J., Sarkisian, Simon A., and Sjulin, Tyson J.

Subjects
Epidemics -- Care and treatment, Central nervous system depressants, Dexamethasone, Coronaviruses, Health
Abstract

Introduction Severe Acute Respiratory Syndrome Coronavirus 2019 (SARS-CoV-2 2019) debuted in Wuhan, China, and has since spread across the globe resulting in thousands of deaths. (1) The World Health Organization [...]

Published
2021

47. Reduction of variable speed drive IGBT switching loss, utilising the IGBT gate drive, without increasing radio frequency radiated emissions

Author

Gibson, Richard Samuel

Subjects
621.3815
Abstract

Radio frequency radiated emission from a variable speed drive must be limited below defined limits to avoid interference with electronic equipment. It is possible to comply with the international standards however, the current state of the art methods such as large gate drive resistance and output filters significantly reduce the efficiency or increase the cost of the products. It is known that the main source of emissions emanate from the switching transients associated with the output power semiconductors, however the exact mechanisms and specific sources are unknown. This thesis examines the interaction of power devices during the switching transient identifying features which can be controlled by a sophisticated gate drive design. Analysis of the frequency content of the signals is presented together with methods to minimise power losses while maintaining compliance with radiated emission standards. A research program has been undertaken to identify the sources responsible for radiated emissions and predict a figure of merit as an indication of compliance. Measuring radio frequency content on high voltage and current signals is difficult and several techniques to accurately achieve this are presented. Simple passive gate drive solutions which can be easily implemented are examined along with a discussion on more complicated optimised solutions.

Published
2013

49. An evaluation of solution design in logistics outsourcing

Author

Gibson, Richard, Slater, Alan, Savage, Chris, and Maden, William

Subjects
600, HE Transportation and Communications
Abstract

Outsourcing within the logistics and supply chain sector is perceived as a method to save money and improve client service levels. The outsourcing process exists within a highly stratified market of service provision and high value commercial arrangements may extend over many years. The client has a responsibility to define the strategy for their supply chain and agree distribution channel objectives which support the wider organisation’s brand delivery. There is a variety of solutions to satisfy these objectives of which outsourcing is one and should be accompanied by clear success criteria as well as a governance structure in order to yield a long term successful commercial arrangement. It is perceived that organisations may not follow an iterative approach towards outsourcing and that failing to adhere to these principles results in a lack of satisfaction for both parties evidenced by high contract turnover rates. This Phd thesis has investigated the issue of solution design within outsourced logistics amongst a group of 400 senior logistics managers through case studies, interviews and a three round Delphi survey. The hypothesis for this investigation was ‘the length and stability of an outsourcing relationship is directly related to the amount of effort expended by the customer in designing their logistics solution’. It was found that clients develop logistics strategy in varying degrees and over varying timescales. Clients measure the cost of supply chain activities with varying frequencies and few follow a straight forward method to define the parameters of a successful supply chain. Within outsourcing arrangements, governance and the management of change were poorly interpreted and executed. The current and future stratifications of logistics service offerings relied on a degree of collaboration between the pursuant parties and it was difficult to determine the effectiveness of these approaches when the balance of power between the parties was so unequal. Both clients and service providers were found to be poorly prepared to grasp the opportunities presented by the rising costs of energy and the future demands of reducing carbon intensity within the sector. Contributions were defined in terms of service level stratification and likely risk, behaviours and a toolkit for clients to observe when working within the outsourced environment as well as the opportunities presented by the changes currently influencing the sector. In conclusion, the hypothesis was found to be valid and the important role the client has to play in specifying and managing their logistics service provision was applicable across the logistics and supply chain industry.

Published
2011

50. Technology and Modern Friendship

Author

Gibson, Richard Hughes

Subjects
Friendship -- Analysis, Technology and society -- Analysis, Modernism -- Social aspects, Technology, Humanities, Social sciences
Abstract

There's no shortage of debate about friendship. --Aristotle, Nicomachean Ethics, 8.1.33 (1) COMPLAINTS ABOUT THE DECLINE OF friendship have become a staple of conversation in our digital times. But before [...]

Published
2019

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